CN112167614A - A dietetic composition for postoperative treatment of tumor patients and radiotherapy and chemotherapy patients, and its preparation method - Google Patents
A dietetic composition for postoperative treatment of tumor patients and radiotherapy and chemotherapy patients, and its preparation method Download PDFInfo
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Abstract
The invention discloses a dietary therapy composition for postoperative tumor patients and patients undergoing radiotherapy and chemotherapy, which comprises the following raw materials in parts by weight: 5-10 parts of grifola frondosa, 4-6 parts of poria cocos, 2-4 parts of tremella, 2-4 parts of agaricus blazei murill, 2-4 parts of hericium erinaceus, 4-6 parts of pine pollen, 4-6 parts of sunflower pollen, 4-6 parts of corn pollen, 4-6 parts of rape pollen and 4-6 parts of buckwheat pollen. Also disclosed are methods for preparing, for example, the above dietary compositions. The dietetic composition is used for tumor patients and patients undergoing radiotherapy and chemotherapy, has effects of strengthening body resistance, consolidating constitution, invigorating qi and spleen, calming heart, tranquilizing mind, nourishing yin and moistening lung, and improving tolerance of tumor patients to radiotherapy and chemotherapy, and is helpful for recovery and nutrition supplementation of tumor patients and patients undergoing radiotherapy and chemotherapy.
Description
Technical Field
The invention belongs to the technical field of food, relates to a food composition with a food therapy function, and particularly relates to a postoperative food therapy composition for tumor patients and patients undergoing radiotherapy and chemotherapy and a preparation method thereof.
Background
With the rapid development of society, the environment around the people also changes greatly, the pollution of the environment and the increase of working pressure have great influence on the health of the people, and according to the WHO report, tumors, cardiovascular diseases and diabetes are three chronic non-infectious diseases threatening the health of the people. After operation, tumor patients and patients with radiotherapy and chemotherapy often suffer from malnutrition and hypoimmunity, and the body becomes weak, so that many patients can eat some traditional Chinese medicine foods after operation to supplement nutrition and improve the immunity of the patients.
The edible fungi are rich in nutrition and delicious in taste, are listed as delicious dishes since ancient times, and are known as 'health foods' containing nutritional ingredients such as protein, low fat, essential amino acids for human bodies, minerals, vitamins and polysaccharides.
Grifola frondosa, also known as millets, lotus flower fungi, bayes, Qianfo fungi and the like, is a rare fungus used as both food and medicine, is delicious in taste, has the names of 'edible fungi prince' and 'North China ginseng', is rich in vitamins, contains various mineral substances beneficial to human bodies, such as zinc, calcium, phosphorus, iron, selenium and the like, has medical health-care effect, contains amino acid and protein which are twice as high as those of lentinus edodes, has the functions of cancer prevention, cancer resistance and improvement of human body immunity, and has obvious curative effects on liver cirrhosis, diabetes, edema, beriberi, dysuria and the like. Can tonify the body and prolong the life after being eaten frequently.
The extract of Maitake Mushroom has been shown to be effective against HIV as early as 1992. In addition to the fact that the Grifola frondosa has the anti-HIV effect in experiments, the Japanese doctor of Kyoho also finds that the Grifola frondosa also has the curative effect on breast cancer, lung cancer and liver cancer; can also improve various adverse reactions caused by tumor chemotherapy, such as anorexia, emesis, nausea, hair loss, leukopenia, etc.; it also has analgesic effect. The specific effects are as follows: 1. activating immune cells such as phagocyte, natural killer cell, nociceptive T cell and the like, and inducing secretion of cytokines such as leucocyte, interferon-gamma, tumor necrosis factor-alpha and the like; 2. inducing apoptosis of cancer cells; 3. the composition can be used together with traditional chemotherapy drugs (mitomycin, carmustine, etc.) to improve drug effect and reduce adverse side effect during chemotherapy; 4. has synergistic effect with immunotherapy drug (interferon-alpha 2 b); 5. relieving pain of late cancer patients, stimulating appetite, and improving life quality of patients; 6. enhancing immunity; 7. reducing insulin resistance, enhancing the sensitivity of human body to insulin, and being helpful for controlling blood sugar; 8. inhibiting adipocyte accumulation; 9. reducing blood pressure.
Poria, a dried sclerotium of Wolf of Poria cocos (Schw.) belonging to Polyporaceae, has effects of promoting diuresis, eliminating dampness, invigorating spleen, and calming heart. As early as the records in the first medical monograph 'Shennong Ben Cao Jing' in China, the book divides the traditional Chinese medicines into an upper product, a middle product and a lower product, and the tuckahoe belongs to one of 120 'upper-grade medicines', has the main life-nourishing effect, is nontoxic, and does not hurt people after being taken for a long time. The professor of Henan university of traditional Chinese medicine shakes away from the health report of the great river in 25.8.2020, and many researchers find that Poria cocos contains pachyman, has the immunoregulatory ability, can activate T lymphocytes and B lymphocytes, and the activation of the two large cells can resist the infection of various bacteria and viruses. In addition, pachyman can resist thymus atrophy and enhance phagocytic ability of macrophage, which enhances immunity from the other side. The study on mouse sarcoma S180 shows that pachyman has good effect of inhibiting tumor generation and development, and in the process of resisting cancer, a new weapon is undoubtedly added, and surprisingly, the poria cocos is safe to eat, has no toxicity and side effect of radiotherapy and chemotherapy, and can be used for preventing tumor and adjuvant therapy of tumor.
Tremella fuciformis, also known as tremella fuciformis, is called as white fungus in quality. Nature and taste: sweet and bland, neutral. The decoction pieces are prepared as follows: sweet and bland, cool. ② modern practical traditional Chinese medicine: sweet, neutral and non-toxic. The functions are mainly as follows: nourish yin, moisten lung, nourish stomach, promote the production of body fluid. It is indicated for cough due to asthenia, blood-stained sputum, deficiency heat and thirst. (ii) Rev of materia Medica: moisten lung and nourish yin. ② the 'materia medica question and answer': it is indicated for dry mouth, consumptive lung disease, phlegm stagnation and cough. ③ decoction pieces New ginseng: clear and nourish lung yin, nourish fluid, treat cough due to overstrain. Fourthly, differentiation of false prescription of increasing order: for dry cough due to lung heat and dryness of lung; bleeding, hemoptysis and bloody sputum. It is known as the crown of bacteria, and is a rare nutrient tonic and a tonic for strengthening body resistance. The tremella is rich in nutrients, and contains protein, fat, amino acids, minerals and glycogen. The tremella protein contains 17 amino acids, and 3/4 tremella among the amino acids necessary for human body can be provided. Tremella also contains various minerals such as calcium, phosphorus, iron, potassium, sodium, magnesium, sulfur, etc., wherein the contents of calcium and iron are high, and each hundred grams of Tremella contains 643 mg of calcium and 30.4 mg of iron. In addition, the tremella contains trehalose, pentosan, mannitol and other glycogen, has high nutritive value, has the function of strengthening body resistance and is a high-grade nourishing tonic. The royal aristocrats in all ages regard the white fungus as a product for prolonging life and a good medicine for growing and being not old. As the traditional edible fungi in China, the edible fungi are always food which is deeply loved by the masses of people. The tremella is rich in vitamin D, can prevent the loss of calcium and is very beneficial to growth and development; the tremella is also a good tonic medicine and is characterized by moistening but not greasy and stagnation. Has the functions of invigorating spleen and promoting appetite, benefiting qi and clearing intestine, promoting sleep and invigorating stomach, nourishing brain, nourishing yin and clearing heat, and moistening dryness, and is a good tonic for patients with yin deficiency and fire excess and without warm nourishing by ginseng antler; the Tremella has effects of strengthening essence, invigorating kidney, moistening intestine, benefiting stomach, invigorating qi, regulating blood, tonifying heart, strengthening body constitution, nourishing brain, refreshing, caring skin, and prolonging life; can be used for treating cough due to lung heat, dry cough due to lung dryness, menoxenia, gastritis, and constipation. It can improve the detoxification ability of the liver and protect the liver function, and can enhance the immunity of the organism for resisting tumor and enhance the tolerance of tumor patients to radiotherapy and chemotherapy due to the rich trace elements such as selenium and the like; the tremella is rich in natural characteristic colloid, and can moisten skin after being taken for a long time due to the function of nourishing yin, and has the efficacy of removing chloasma and freckles on the face; the tremella is a weight-losing food containing dietary fiber, and the dietary fiber of the tremella can assist gastrointestinal motility and reduce fat absorption.
Agaricus blazei, a saprophytic fungus growing in summer and autumn, is regarded as a substance strongly resisting the filterable virus, can prevent the virus and harmful objects from entering the fragile tissues of the body, can promote the function of the immune system, and the extract of the Agaricus blazei is the first of various medicinal anticancer fungi for improving the immunity of the human body, and is a special supplement for people who use radiotherapy and chemotherapy. The agaricus blazei murill has high nutritional and medicinal values, and has sufficient theoretical basis and clinical tests for research and development and clinical tests of the agaricus blazei murill as a health food.
Hericium erinaceus, also known as Hericium erinaceus, Hedgehog fungusFungiThe fruiting body of Hericium erinaceus (Bull. Ex Fr.) pers) belonging to phylum Phycomycota is a precious edible fungus, has mild nature and sweet taste, and has effects of promoting digestion and benefiting five internal organs. The Hericium erinaceus contains polysaccharides, polypeptides and fatty substances, and can inhibit synthesis of genetic material in cancer cells, thereby preventing and treating digestive tract cancer and other malignant tumors.
Pine pollen, nature and taste: sweet and warm. Meridian tropism: it enters liver and spleen meridians. The efficacy is as follows: astringe to stop bleeding, dry dampness and heal wound. The main treatment is as follows: can be used for treating traumatic hemorrhage, eczema, impetigo, skin erosion, and urorrhea. Has antiviral, astringent, and hemostatic effects. In addition, it has the functions of increasing endurance and resisting fatigue. Pharmacological research shows that the pine pollen contains selenium for inhibiting tumor cells.
The sunflower pollen has effects of clearing heat, eliminating phlegm, cooling blood, stopping bleeding, regulating endocrine, and promoting skin metabolism, and can be used for treating headache and dizziness.
The corn pollen has the effects of promoting blood circulation, promoting urination and reducing blood pressure, and has a considerable curative effect on strengthening the body resistance and consolidating the constitution of the renal function of a human body. A large number of experimental studies show that the corn pollen can promote the development of spleen, bone, lymph node and thymus immune organs, enhance the activity of immune cells and improve the capability of the organism to resist bacteria and viruses; it also has radioprotective and anticancer effects. Meanwhile, the corn pollen can provide various nutrient components required by a human body, and has good auxiliary curative effect on diseases caused by lack of certain nutrition. Therefore, the corn pollen has wide application in clinic and can be used as a therapeutic supplement for various diseases and a supplement for daily nutrition.
The rape pollen contains high content of flavonol, and has effects of resisting atherosclerosis, treating varicose ulcer and prostatitis, reducing cholesterol and resisting radiation, and the rape pollen contains pollen polysaccharide which can activate phagocytic activity of macrophage and improve disease resistance of human body.
The buckwheat pollen has good rutin content, has strong protective effect on capillary wall, and can be used for preventing and treating bleeding and hemorrhage. It also has effects in promoting heart contraction, slowing heart rate, and can be used for treating palpitation, heart failure, anemia, and capillary weakness.
Bee pollen refers to pollen balls brought back by bees during honey collection, and pollen formed after storage and fermentation in a honeycomb. It not only carries the genetic information of life, but also contains all the nutrients necessary for breeding new life, and is the root of plant succession and the source of heat energy. Scientists have demonstrated that pollen contains many nutrients, including 22 of themAmino acids14 vitamins and more than 30 trace elements and a large amount of active protease, nucleic acid, flavonoid compounds and other active substances. Has the functions of enhancing the immunologic function, resisting aging, assisting in treating anemia and the like. The bee pollen has natural health care function and medical and beauty values, is recognized by more and more people, is a high-protein low-fat nutritional health food, is known as 'omnipotent nutritional food', 'concentrated natural medicine library', 'cosmetic for oral administration' and the like, and is treasure in natural food of human beings. In recent years, there have been many reports on the research of bee pollen, for example, in Yujin, "the research progress of pharmacological action of bee pollen", Chinese herbal medicine, pp 37-39 of fifth phase, Vol 21 in 1990; qianbaiyu, a new development of bee pollen nutrition and pharmacology research, J.J.Med.Med.Med.Med.Med.Med., No. 9, No. 2, page 125-127 in 1989. The five kinds of pollen in the invention belong to bee pollen, and have the function of full nutrition.
Medical research now shows that many probiotic fungi have the effects of improving human immune cells and inhibiting the growth and spread of tumor cells, and for example, the following reports are available: maorenggang et al, Maitake Mushroom polysaccharide research progress, 34 nd Vol.2, 2003-2 months; li Xiao, et al, progress of pharmacological research on Grifola frondosa polysaccharide, research and development of natural drugs, vol.B No.4364 page 368 in 2003; guoqian et al, progress in Agaricus blazei Murill research, vol 11, vol 2, 2004: pages 59-64. However, most of the fungi are applied to single strain products, and although the fungi have certain curative effect in the aspect of taking, the curative effect is not ideal. There are also patents that study the combination ratio of various fungi to achieve better therapeutic effect, such as: chinese patent application CN1283419A discloses a health beverage comprising various Ganoderma and edible fungi, Chinese patent application CN1176765A discloses an oral liquid prepared by fermentation broth of Ganoderma, Armillaria mellea and Lentinus edodes in combination with other adjuvants, the above products are prepared by simply proportioning culture of beneficial fungi, and the specific efficacy is not clear. The five fungi in the invention are prepared according to a proportioning scheme determined by repeated experiments, and have the effects of tonifying spleen, calming heart, nourishing yin, promoting fluid production, nourishing stomach, regulating immunity and inhibiting tumors; few research reports exist on the application of food therapy traditional Chinese medicine products combining various different types of fungi and various different types of pollen to tumor patients and patients suffering from radiotherapy and chemotherapy.
Disclosure of Invention
In order to solve the defects in the prior art, the invention aims to provide a dietary therapy composition for postoperative patients with tumor and radiotherapy and chemotherapy. The composition has effects in strengthening body resistance, consolidating constitution, invigorating qi, invigorating spleen, calming heart, tranquilizing mind, nourishing yin, moistening lung, regulating immunity, inhibiting tumor, enhancing tolerance of tumor patients, radiotherapy and chemotherapy, recovering body, and supplementing nutrition.
The invention also aims to provide a preparation method of the food therapy composition.
In order to achieve the two purposes, the invention adopts the following technical scheme:
a dietary therapy composition for postoperative tumor patients and patients with radiotherapy and chemotherapy comprises the following raw materials in parts by weight: 5-10 parts of grifola frondosa, 4-6 parts of poria cocos, 2-4 parts of tremella, 2-4 parts of agaricus blazei murill, 2-4 parts of hericium erinaceus, 4-6 parts of pine pollen, 4-6 parts of sunflower pollen, 4-6 parts of corn pollen, 4-6 parts of rape pollen and 4-6 parts of buckwheat pollen.
Further, the dietary therapy composition for postoperative tumor patients and patients with radiotherapy and chemotherapy comprises the following raw materials in parts by weight: 8 parts of grifola frondosa, 5 parts of poria cocos, 3 parts of tremella, 3 parts of agaricus blazei murill, 3 parts of hericium erinaceus, 5 parts of pollen pini, 5 parts of sunflower pollen, 5 parts of corn pollen, 5 parts of rape pollen and 5 parts of buckwheat pollen.
Further, a preparation method of the dietary therapy composition for tumor patients and patients after radiotherapy and chemotherapy mainly comprises the following steps:
(1) weighing the raw materials in parts by weight, and cleaning part of the raw materials, namely grifola frondosa, poria cocos, tremella, agaricus blazei murill and hericium erinaceus;
(2) vacuum drying part of the cleaned raw materials in the step (1);
(3) respectively putting part of the dried raw materials in the step (2) into a universal pulverizer to be pulverized, and then sequentially sieving the pulverized raw materials by a 100-mesh sieve to obtain required part of raw material powder for later use;
(4) respectively breaking the walls of the partial raw materials of the pollen pini, the sunflower pollen, the corn pollen, the rape pollen and the buckwheat pollen weighed in the step (1) by using a wall breaking machine, and sequentially sieving by using a 100-mesh sieve to obtain the required partial raw material powder for later use;
(5) putting the raw material powder obtained in the steps (3) and (4) into a high-pressure homogenizer according to a certain proportion, homogenizing and mixing;
(6) transferring the uniformly mixed raw materials in the step (5) into a packaging machine, and carrying out vacuum packaging;
(7) and (4) carrying out ultrahigh pressure sterilization on the raw materials subjected to vacuum packaging in the step (6) to obtain the product.
Further, in the step (1), the grifola frondosa, the poria cocos, the tremella, the agaricus blazei murill and the hericium erinaceus are respectively cleaned by a spray cleaning machine, the cleaning time is 5-10 minutes, and the cleaning water temperature is 20-25 ℃.
Further, the vacuum drying in the step (2) is divided into two times, the first time vacuum drying time is 2-4h, and the vacuum drying temperature is 35-45 ℃; the second vacuum drying time is 20-30min, and the vacuum drying temperature is 100-.
Further, the rotation speed of the pulverizer in the step (3) during pulverizing is 2900-.
Further, the wall breaking in the step (4) is performed twice, the rotating speed of the wall breaking machine is 5800r/min during wall breaking each time, and the wall breaking time is 30s each time.
Further, the pressure for high-pressure homogenization in the step (5) is 100-600MPa, and the homogenization time is 10-15 min.
Further, the pressure of the ultra-high pressure sterilization in the step (7) is 400-600 Mpa, and the sterilization time is 10-30 min.
Compared with the prior art, the invention has the beneficial effects that:
(1) the invention adopts five-fungus five-pollen as raw materials to prepare a dietotherapy composition used after tumor patients and chemoradiotherapy operations, wherein the five fungi are grifola frondosa, poria cocos, tremella, agaricus blazei murill and hericium erinaceus; the five-pollen powder is pollen Pini, sunflower pollen, corn pollen, rape pollen, and buckwheat pollen. The agaricus blazei murill can be used as a special supplement for chemotherapy patients, and the hericium erinaceus has the effects of helping digestion and benefiting five internal organs. The five kinds of pollen contain multiple nutrients, including 22 kindsAmmonia Amino acid14 vitamins, more than 30 trace elements, a large amount of active protease, nucleic acid, flavonoid compounds and other active substances, has the effects of tonifying qi, strengthening body resistance and consolidating constitution, and can also promote metabolism. Therefore, the five-fungus five-pollen dietary therapy composition has the effects of strengthening body resistance and consolidating constitution, tonifying qi and spleen, calming heart and tranquilizing mind, nourishing yin and moisturizing lung, regulating immunity, inhibiting tumor, improving the tolerance of tumor patients to radiotherapy and chemotherapy, and contributing to recovery and nutrition supplement of tumor patients and radiotherapy and chemotherapy patients.
(2) The five-fungus five-pollen dietary therapy composition disclosed by the invention is easy to accept in taste, reasonable in proportion, convenient to take, free of toxic and side effects and suitable for long-term taking.
Detailed Description
The following further describes the embodiments of the present invention. It should be noted that the description of the embodiments is provided to help understanding of the present invention, but the present invention is not limited thereto. In addition, the technical features involved in the embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
Example 1
A dietary therapy composition for postoperative tumor patients and patients with radiotherapy and chemotherapy comprises the following raw materials in parts by weight: 5 parts of grifola frondosa, 4 parts of poria cocos, 2 parts of tremella, 2 parts of agaricus blazei murill, 2 parts of hericium erinaceus, 4 parts of pollen pini, 4 parts of sunflower pollen, 4 parts of corn pollen, 4 parts of rape pollen and 4 parts of buckwheat pollen.
The preparation method of the dietary therapy composition for the tumor patients and the patients after radiotherapy and chemotherapy mainly comprises the following steps:
(1) weighing the raw materials in parts by weight, and respectively cleaning part of fungus raw materials, namely grifola frondosa, poria cocos, tremella, agaricus blazei murill and hericium erinaceus, by using a spray cleaning machine for 5 minutes at the cleaning water temperature of 20 ℃;
(2) vacuum drying the cleaned grifola frondosa, poria cocos, tremella, agaricus blazei and hericium erinaceus in the step (1) twice, wherein the first vacuum drying time is 2 hours, and the vacuum drying temperature is 35 ℃; the second vacuum drying time is 20min, and the vacuum drying temperature is 100 ℃;
(3) respectively putting the dried grifola frondosa, poria cocos, tremella fuciformis, agaricus blazei murrill and hericium erinaceus in the step (2) into a universal pulverizer with the model HT700 for pulverizing, wherein the rotation speed of the pulverizer during pulverizing is 2900r/min, the pulverizing time is 2min, and the pulverized grifola frondosa, poria cocos, tremella fuciformis, agaricus blazei murrill and hericium erinaceus are respectively sieved by a 100-mesh sieve to obtain required partial fungus raw material powder for later use;
(4) respectively putting pollen pini, sunflower pollen, corn pollen, rape pollen and buckwheat pollen which are taken as pollen raw materials in the step (1) into a wall breaking machine of a model ZD10L in sequence for wall breaking, wherein the wall breaking of each pollen raw material is carried out twice, the rotating speed of the wall breaking machine during working is 5800r/min each time, the wall breaking time is 30s each time, and sieving the pollen raw materials with a 100-mesh sieve in sequence after the wall breaking is finished to obtain the required pollen raw material powder for later use;
(5) putting the raw material powder obtained in the steps (3) and (4) into a high-pressure homogenizer of a model DC-0029 according to a certain proportion, homogenizing and mixing, wherein the pressure of the high-pressure homogenizer is 100Mpa when homogenizing, and the homogenizing time is 10 min;
(6) transferring the uniformly mixed raw materials in the step (5) into a packaging machine, and carrying out vacuum packaging;
(7) and (4) carrying out ultrahigh pressure sterilization on the raw materials subjected to vacuum packaging in the step (6), wherein the ultrahigh pressure sterilization pressure is 400Mpa, and the sterilization time is 10min, so as to obtain the food therapy composition for the tumor patients and the patients after radiotherapy and chemotherapy.
Example 2
A dietary therapy composition for postoperative tumor patients and patients with radiotherapy and chemotherapy comprises the following raw materials in parts by weight: 6 parts of grifola frondosa, 5 parts of poria cocos, 3 parts of tremella, 3 parts of agaricus blazei murill, 3 parts of hericium erinaceus, 5 parts of pollen pini, 5 parts of sunflower pollen, 5 parts of corn pollen, 5 parts of rape pollen and 5 parts of buckwheat pollen.
The preparation method of the dietary therapy composition for the tumor patients and the patients after radiotherapy and chemotherapy mainly comprises the following steps:
(1) weighing the raw materials in parts by weight, and respectively cleaning part of fungus raw materials, namely grifola frondosa, poria cocos, tremella, agaricus blazei murill and hericium erinaceus, by using a spray cleaning machine for 7 minutes at the cleaning water temperature of 22 ℃;
(2) vacuum drying the cleaned grifola frondosa, poria cocos, tremella, agaricus blazei and hericium erinaceus in the step (1) twice, wherein the first vacuum drying time is 3 hours, and the vacuum drying temperature is 38 ℃; the second vacuum drying time is 24min, and the vacuum drying temperature is 105 ℃;
(3) respectively putting the dried grifola frondosa, poria cocos, tremella fuciformis, agaricus blazei murrill and hericium erinaceus in the step (2) into a universal pulverizer of type HT700 for pulverizing, wherein the rotation speed of the pulverizer is 3400r/min, the pulverizing time is 3min, and the pulverized grifola frondosa, poria cocos, tremella fuciformis, agaricus blazei murrill and hericium erinaceus are respectively sieved by a 100-mesh sieve to obtain required partial fungus raw material powder for later use;
(4) respectively putting pollen pini, sunflower pollen, corn pollen, rape pollen and buckwheat pollen which are taken as pollen raw materials in the step (1) into a wall breaking machine of a model ZD10L in sequence for wall breaking, wherein the wall breaking of each pollen raw material is carried out twice, the rotating speed of the wall breaking machine during working is 5800r/min each time, the wall breaking time is 30s each time, and sieving the pollen raw materials with a 100-mesh sieve in sequence after the wall breaking is finished to obtain the required pollen raw material powder for later use;
(5) putting the raw material powder obtained in the steps (3) and (4) into a high-pressure homogenizer of a model DC-0029 according to a certain proportion, homogenizing and mixing, wherein the pressure of the high-pressure homogenizer is 300Mpa when homogenizing, and the homogenizing time is 12 min;
(6) transferring the uniformly mixed raw materials in the step (5) into a packaging machine, and carrying out vacuum packaging;
(7) and (4) carrying out ultrahigh pressure sterilization on the raw materials subjected to vacuum packaging in the step (6), wherein the ultrahigh pressure sterilization pressure is 450Mpa, and the sterilization time is 18min, so that the food therapy composition for the tumor patients and the patients after radiotherapy and chemotherapy is obtained.
Example 3
A dietary therapy composition for postoperative tumor patients and patients with radiotherapy and chemotherapy comprises the following raw materials in parts by weight: 8 parts of grifola frondosa, 6 parts of poria cocos, 4 parts of tremella, 4 parts of agaricus blazei murill, 4 parts of hericium erinaceus, 6 parts of pollen pini, 6 parts of sunflower pollen, 6 parts of corn pollen, 6 parts of rape pollen and 6 parts of buckwheat pollen.
The preparation method of the dietary therapy composition for the tumor patients and the patients after radiotherapy and chemotherapy mainly comprises the following steps:
(1) weighing the raw materials in parts by weight, and respectively cleaning part of fungus raw materials, namely grifola frondosa, poria cocos, tremella, agaricus blazei murill and hericium erinaceus, by using a spray cleaning machine for 8 minutes at the cleaning water temperature of 24 ℃;
(2) vacuum drying the cleaned grifola frondosa, poria cocos, tremella, agaricus blazei and hericium erinaceus in the step (1) twice, wherein the first vacuum drying time is 3 hours, and the vacuum drying temperature is 40 ℃; the second vacuum drying time is 27min, and the vacuum drying temperature is 110 ℃;
(3) respectively putting the dried grifola frondosa, poria cocos, tremella fuciformis, agaricus blazei murrill and hericium erinaceus in the step (2) into a universal pulverizer with the model HT700 for pulverizing, wherein the rotation speed of the pulverizer during pulverizing is 3800r/min, the pulverizing time is 4min, and the pulverized grifola frondosa, poria cocos, tremella fuciformis, agaricus blazei murrill and hericium erinaceus are respectively sieved by a 100-mesh sieve to obtain required partial fungus raw material powder for later use;
(4) respectively putting pollen pini, sunflower pollen, corn pollen, rape pollen and buckwheat pollen which are taken as pollen raw materials in the step (1) into a wall breaking machine of a model ZD10L in sequence for wall breaking, wherein the wall breaking of each pollen raw material is carried out twice, the rotating speed of the wall breaking machine during working is 5800r/min each time, the wall breaking time is 30s each time, and sieving the pollen raw materials with a 100-mesh sieve in sequence after the wall breaking is finished to obtain the required pollen raw material powder for later use;
(5) putting the raw material powder obtained in the steps (3) and (4) into a high-pressure homogenizer of a model DC-0029 according to a certain proportion, homogenizing and mixing, wherein the pressure of the high-pressure homogenizer is 450MPa, and the homogenizing time is 13 min;
(6) transferring the uniformly mixed raw materials in the step (5) into a packaging machine, and carrying out vacuum packaging;
(7) and (4) carrying out ultrahigh pressure sterilization on the raw materials subjected to vacuum packaging in the step (6), wherein the ultrahigh pressure sterilization pressure is 500Mpa, and the sterilization time is 20min, so as to obtain the food therapy composition for the tumor patients and the patients after radiotherapy and chemotherapy.
Example 4
A dietary therapy composition for postoperative tumor patients and patients with radiotherapy and chemotherapy comprises the following raw materials in parts by weight: 10 parts of grifola frondosa, 6 parts of poria cocos, 4 parts of tremella, 3 parts of agaricus blazei murill, 3 parts of hericium erinaceus, 5 parts of pollen pini, 5 parts of sunflower pollen, 5 parts of corn pollen, 6 parts of rape pollen and 6 parts of buckwheat pollen.
The preparation method of the dietary therapy composition for the tumor patients and the patients after radiotherapy and chemotherapy mainly comprises the following steps:
(1) weighing the raw materials in parts by weight, and respectively cleaning part of fungus raw materials, namely grifola frondosa, poria cocos, tremella, agaricus blazei murill and hericium erinaceus, by using a spray cleaning machine for 10 minutes at the cleaning water temperature of 25 ℃;
(2) vacuum drying the cleaned Grifola frondosa, Poria cocos, Tremella, Agaricus blazei Murill and Hericium erinaceus twice at 42 deg.C for 3.5 h; the second vacuum drying time is 28min, and the vacuum drying temperature is 105 ℃;
(3) respectively putting the dried grifola frondosa, poria cocos, tremella fuciformis, agaricus blazei murrill and hericium erinaceus in the step (2) into a universal grinder of type HT700 for grinding, wherein the rotation speed of the grinder during grinding is 3900r/min, the grinding time is 5min, and the ground grifola frondosa, poria cocos, tremella fuciformis, agaricus blazei murrill and hericium erinaceus are respectively sieved by a 100-mesh sieve to obtain required partial fungus raw material powder for later use;
(4) respectively putting pollen pini, sunflower pollen, corn pollen, rape pollen and buckwheat pollen which are taken as pollen raw materials in the step (1) into a wall breaking machine of a model ZD10L in sequence for wall breaking, wherein the wall breaking of each pollen raw material is carried out twice, the rotating speed of the wall breaking machine during working is 5800r/min each time, the wall breaking time is 30s each time, and sieving the pollen raw materials with a 100-mesh sieve in sequence after the wall breaking is finished to obtain the required pollen raw material powder for later use;
(5) putting the raw material powder obtained in the steps (3) and (4) into a high-pressure homogenizer of a model DC-0029 according to a certain proportion, homogenizing and mixing, wherein the pressure of the high-pressure homogenizer is 540MPa, and the homogenizing time is 14 min;
(6) transferring the uniformly mixed raw materials in the step (5) into a packaging machine, and carrying out vacuum packaging;
(7) and (4) carrying out ultrahigh pressure sterilization on the raw materials subjected to vacuum packaging in the step (6), wherein the ultrahigh pressure sterilization pressure is 550Mpa, and the sterilization time is 24min, thus obtaining the food therapy composition for tumor patients and patients after radiotherapy and chemotherapy.
Example 5
A dietary therapy composition for postoperative tumor patients and patients with radiotherapy and chemotherapy comprises the following raw materials in parts by weight: 10 parts of grifola frondosa, 6 parts of poria cocos, 4 parts of tremella, 4 parts of agaricus blazei murill, 4 parts of hericium erinaceus, 5 parts of pollen pini, 5 parts of sunflower pollen, 6 parts of corn pollen, 6 parts of rape pollen and 6 parts of buckwheat pollen.
The preparation method of the dietary therapy composition for the tumor patients and the patients after radiotherapy and chemotherapy mainly comprises the following steps:
(1) weighing the raw materials in parts by weight, and respectively cleaning part of fungus raw materials, namely grifola frondosa, poria cocos, tremella, agaricus blazei murill and hericium erinaceus, by using a spray cleaning machine for 10 minutes at the cleaning water temperature of 25 ℃;
(2) vacuum drying the cleaned grifola frondosa, poria cocos, tremella, agaricus blazei and hericium erinaceus in the step (1) twice, wherein the first vacuum drying time is 4 hours, and the vacuum drying temperature is 45 ℃; the second vacuum drying time is 30min, and the vacuum drying temperature is 105 ℃;
(3) respectively putting the dried grifola frondosa, poria cocos, tremella fuciformis, agaricus blazei murrill and hericium erinaceus in the step (2) into a universal pulverizer with the model HT700 for pulverizing, wherein the rotation speed of the pulverizer during pulverizing is 4000r/min, the pulverizing time is 5min, and respectively sieving the pulverized grifola frondosa, poria cocos, tremella fuciformis, agaricus blazei murrill and hericium erinaceus with a 100-mesh sieve to obtain required partial fungus raw material powder for later use;
(4) respectively putting pollen pini, sunflower pollen, corn pollen, rape pollen and buckwheat pollen which are taken as pollen raw materials in the step (1) into a wall breaking machine of a model ZD10L in sequence for wall breaking, wherein the wall breaking of each pollen raw material is carried out twice, the rotating speed of the wall breaking machine during working is 5800r/min each time, the wall breaking time is 30s each time, and sieving the pollen raw materials with a 100-mesh sieve in sequence after the wall breaking is finished to obtain the required pollen raw material powder for later use;
(5) putting the raw material powder obtained in the steps (3) and (4) into a high-pressure homogenizer of a model DC-0029 according to a certain proportion, homogenizing and mixing, wherein the pressure of the high-pressure homogenizer is 560Mpa when homogenizing, and the homogenizing time is 15 min;
(6) transferring the uniformly mixed raw materials in the step (5) into a packaging machine, and carrying out vacuum packaging;
(7) and (4) carrying out ultrahigh pressure sterilization on the raw materials subjected to vacuum packaging in the step (6), wherein the pressure of the ultrahigh pressure sterilization is 580Mpa, and the sterilization time is 28min, thus obtaining the food therapy composition for the tumor patients and the patients after the radiotherapy and chemotherapy.
Example 6
A dietary therapy composition for postoperative tumor patients and patients with radiotherapy and chemotherapy comprises the following raw materials in parts by weight: 10 parts of grifola frondosa, 6 parts of poria cocos, 4 parts of tremella, 4 parts of agaricus blazei murill, 4 parts of hericium erinaceus, 6 parts of pollen pini, 6 parts of sunflower pollen, 6 parts of corn pollen, 6 parts of rape pollen and 6 parts of buckwheat pollen.
The preparation method of the dietary therapy composition for the tumor patients and the patients after radiotherapy and chemotherapy mainly comprises the following steps:
(1) weighing the raw materials in parts by weight, and respectively cleaning part of fungus raw materials, namely grifola frondosa, poria cocos, tremella, agaricus blazei murill and hericium erinaceus, by using a spray cleaning machine for 10 minutes at the cleaning water temperature of 25 ℃;
(2) vacuum drying the cleaned grifola frondosa, poria cocos, tremella, agaricus blazei and hericium erinaceus in the step (1) twice, wherein the first vacuum drying time is 4 hours, and the vacuum drying temperature is 45 ℃; the second vacuum drying time is 30min, and the vacuum drying temperature is 110 ℃;
(3) respectively putting the dried grifola frondosa, poria cocos, tremella fuciformis, agaricus blazei murrill and hericium erinaceus in the step (2) into a universal pulverizer with the model HT700 for pulverizing, wherein the rotation speed of the pulverizer during pulverizing is 4000r/min, the pulverizing time is 5min, and respectively sieving the pulverized grifola frondosa, poria cocos, tremella fuciformis, agaricus blazei murrill and hericium erinaceus with a 100-mesh sieve to obtain required partial fungus raw material powder for later use;
(4) respectively putting pollen pini, sunflower pollen, corn pollen, rape pollen and buckwheat pollen which are taken as pollen raw materials in the step (1) into a wall breaking machine of a model ZD10L in sequence for wall breaking, wherein the wall breaking of each pollen raw material is carried out twice, the rotating speed of the wall breaking machine during working is 5800r/min each time, the wall breaking time is 30s each time, and sieving the pollen raw materials with a 100-mesh sieve in sequence after the wall breaking is finished to obtain the required pollen raw material powder for later use;
(5) putting the raw material powder obtained in the steps (3) and (4) into a high-pressure homogenizer of a model DC-0029 according to a certain proportion, homogenizing and mixing, wherein the pressure of the high-pressure homogenizer is 600Mpa when homogenizing, and the homogenizing time is 15 min;
(6) transferring the uniformly mixed raw materials in the step (5) into a packaging machine, and carrying out vacuum packaging;
(7) and (4) carrying out ultrahigh pressure sterilization on the raw materials subjected to vacuum packaging in the step (6), wherein the ultrahigh pressure sterilization pressure is 600Mpa, and the sterilization time is 30min, so as to obtain the food therapy composition for the tumor patients and the patients after radiotherapy and chemotherapy.
Test examples
Quality and hygiene index detection
The quality index detection is carried out on the five-fungus five-pollen by adopting a sampling investigation method: sampling detection shows that the package breakage rate is very low, and the weight difference is within a specified range; the sanitary index meets the regulation: the mixed bacteria index is less than or equal to 500CFU/ml, the Escherichia coli is less than or equal to 0.43CFU/ml, and other bacteria cannot be detected.
II, animal toxicology test:
the purpose is to observe the change of immunity of the white mice after taking the five-fungus five-pollen diet therapy composition prepared by the invention.
The method comprises the following steps: selecting 20 mice as a tested object, dividing the mice into four groups, dividing each group into 5 mice, respectively taking 4 doses of 5, 10, 15 and 20g/Kg, respectively orally taking 5 rats in each dose for 80 days, and observing the growth and development, blood and histopathological changes and immunity changes of the mice at 40-80 days and the change of the indexes at 30 days after stopping taking the mice. According to observation, after the administration for 40-80 days and the withdrawal for 30 days, the food intake, activity, peripheral hemogram and important organ coefficient of the white mice are normal, and the immunity is improved.
The conclusion is that through observation of various index reactions in the test process, no toxic or side effect is generated in mice, and the immunity is also improved, so that the five-fungus five-pollen dietary therapy composition for tumor patients and patients after radiotherapy and chemotherapy is safe and reliable to apply under the specified dosage.
Thirdly, clinical tests:
1. selection criteria for clinical subjects
Tumor patients and postoperative patients of radiotherapy and chemotherapy
2. Exclusion criteria
1) Allergic to pollen
2) Those with severe cognitive and intellectual impairment
3) Patients with poor treatment compliance
4) Experimenters who have serious adverse reactions or special physiological changes in the treatment process and are not suitable for continuous acceptance
3. Treatment regimens
The five-fungus five-pollen dietary therapy composition is orally taken for tumor patients and patients after radiotherapy and chemotherapy, once a day and 20 days as a course of treatment.
4. Evaluation of therapeutic Effect
1) The improvement of the principal symptoms is compared with the improvement of the physical conditions before and after taking the product.
2) And (3) biochemical treatment: blood routine, liver and kidney function, immunoglobulin and immune cell detection.
3) B, ultrasonic wave: the size change of the tumor was observed.
4) And (3) safety detection: subjects were observed for emerging symptoms and signs (fever, nausea, rash, etc.).
5. Results
The observation of the physical conditions of 100 subjects (50 tumor patients without radiotherapy and chemotherapy and 50 patients after radiotherapy and chemotherapy) after taking the product shows that the immunoglobulin and immune cell indexes of the 100 subjects are obviously increased compared with those of the subjects before taking the product, and no new symptoms and signs appear.
6. Typical cases are:
(1) a king is somebody, a woman is 45 years old, after the breast cancer chemotherapy, nausea and vomiting after chemotherapy, dizziness and weakness cannot be caused, the body is weak, the woman cannot get out of bed, white blood cells are lower than a normal value, half pack of five-fungus five-pollen is persuaded to take at home every time, after the three-day persistence, dizziness and weakness turn better, the woman can be assisted after a week, the woman gets out of bed to walk, the dizziness and weakness disappear after taking for half a month, the woman can get out of bed to move, and the conventional blood detection shows that the white blood cells are recovered to be normal.
(2) Zhengyi one, male, 56 years old, confirmed to be small cell lung cancer by hemoptysis examination in hospital, chemotherapy, white blood cell below 3 after chemotherapy, dizziness and hypodynamia, limb soreness, anorexia, through the patient friend recommend to start taking five fungus five pollen, two consecutive days of dizziness and hypodynamia relief, limb feeling is vigorous, the dizziness and hypodynamia disappear after the subsequent continuous taking for one week, appetite is recovered slowly, white blood cell is also increased slowly.
(3) The patient is advised to try to take the medicine, after taking the medicine for one week, the patient is better in spirit, after taking the medicine for two weeks, the patient can stand up by himself, feels effective and willing to continue taking the medicine, and after one month, the biochemical indexes are checked to be normal.
(4) Some people, male, 60 years old, have undergone chemotherapy and consolidation after esophageal cancer operation, have nausea and no food intake after chemotherapy, have dizziness and hypodynamia, adopt western medicine conventional treatment to stop vomiting, increase nutrition, and patients have poor feelings of mental, and know that five-fungus five-pollen can be used for postoperative recovery of patients with radiotherapy and chemotherapy, so that the patients try to take the medicine, and the patients have a better feeling after taking the medicine for 3 days.
(5) After a certain person is congratulated for a male and 55 years old and esophageal cancer operation, multiple chemotherapies are carried out, diet is reduced, the body is thinned, the spirit is low, fever occurs sometimes, biochemical detection shows that both leucocyte and immunoglobulin are lower than normal values, five-fungus five-pollen is recommended to be taken by family people, after two weeks, the spirit of a patient is improved, the family people can carry out proper activities under the assistance of the family people, the result of the biochemical detection shows that the leucocyte immunoglobulin is improved to some extent, the family people feel effective, and the patient is persuaded to continue to take the medicine.
(6) Certain horse, male, 30 years old, advanced bile duct cancer, multiple metastasis, nausea after chemotherapy, general aching and pain, anorexia, maintain nutrition by infusion, family feel completely depend on infusion to maintain nutrition, the symptoms are not the root cause, the problem of malnutrition of patients cannot be solved fundamentally, patients are recommended to take five-fungus five-pollen to increase nutrition, patients feel better after taking for 5 days continuously, and liquid input is reduced.
(7) The plum is a certain plum, a woman, 80 years old and lung cancer, because of the older age, families do not want to perform an operation, conservative treatment is adopted, because of the relation between the disease condition and the age, the patient often suffers from chest distress and short breath, and in addition, the diet is not good and the body is thin, after the patient takes five-fungus five-pollen for 20 days, the physical condition is improved, after taking two months, the chest distress and short breath condition is greatly improved, the diet is increased, the weight is also increased, and the biochemical detection result shows that all the conditions are normal.
Although the invention has been described in detail hereinabove with respect to a general description and specific embodiments thereof, it will be apparent to those skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.
Claims (9)
1. A dietary therapy composition for postoperative tumor patients and patients with radiotherapy and chemotherapy is characterized by comprising the following raw materials in parts by weight: 5-10 parts of grifola frondosa, 4-6 parts of poria cocos, 2-4 parts of tremella, 2-4 parts of agaricus blazei murill, 2-4 parts of hericium erinaceus, 4-6 parts of pine pollen, 4-6 parts of sunflower pollen, 4-6 parts of corn pollen, 4-6 parts of rape pollen and 4-6 parts of buckwheat pollen.
2. The dietetic composition for post-operative treatment of neoplastic patients and patients undergoing radiotherapy and chemotherapy according to claim 1, characterized in that it consists of the following raw materials in parts by weight: 8 parts of grifola frondosa, 5 parts of poria cocos, 3 parts of tremella, 3 parts of agaricus blazei murill, 3 parts of hericium erinaceus, 5 parts of pollen pini, 5 parts of sunflower pollen, 5 parts of corn pollen, 5 parts of rape pollen and 5 parts of buckwheat pollen.
3. A process for the preparation of a dietetic composition according to claims 1 or 2 for use in post-operative treatment of neoplastic patients and patients undergoing radiotherapy and chemotherapy, characterized in that it essentially comprises the following steps:
(1) weighing the raw materials in parts by weight, and cleaning part of the raw materials, namely grifola frondosa, poria cocos, tremella, agaricus blazei murill and hericium erinaceus;
(2) vacuum drying part of the cleaned raw materials in the step (1);
(3) respectively putting part of the dried raw materials in the step (2) into a universal pulverizer to be pulverized, and then sequentially sieving the pulverized raw materials by a 100-mesh sieve to obtain required part of raw material powder for later use;
(4) respectively breaking the walls of the partial raw materials of the pollen pini, the sunflower pollen, the corn pollen, the rape pollen and the buckwheat pollen weighed in the step (1) by using a wall breaking machine, and sequentially sieving by using a 100-mesh sieve to obtain the required partial raw material powder for later use;
(5) putting the raw material powder obtained in the steps (3) and (4) into a high-pressure homogenizer according to a certain proportion, homogenizing and mixing;
(6) transferring the uniformly mixed raw materials in the step (5) into a packaging machine, and carrying out vacuum packaging;
(7) and (4) carrying out ultrahigh pressure sterilization on the raw materials subjected to vacuum packaging in the step (6) to obtain the product.
4. The method for preparing a dietary composition for post-operation of neoplastic patients and patients undergoing radiotherapy and chemotherapy according to claim 3, wherein the grifola frondosa, poria cocos, tremella alba, agaricus blazei murill and hericium erinaceus are respectively cleaned by a spray cleaning machine in the step (1) for 5-10 minutes at a temperature of 20-25 ℃.
5. The method for preparing a dietary composition for post-operation of tumor patients and patients undergoing radiotherapy and chemotherapy according to claim 3, wherein the vacuum drying in step (2) is divided into two times, the first time is 2-4h, and the vacuum drying temperature is 35-45 ℃; the second vacuum drying time is 20-30min, and the vacuum drying temperature is 100-.
6. The method for preparing a dietary composition for post-operation treatment of tumor patients and patients undergoing radiotherapy and chemotherapy according to claim 3, wherein the rotation speed of the pulverizer in the step (3) is 2900-.
7. The method for preparing a dietary composition for post-operation of tumor patients and patients undergoing radiotherapy and chemotherapy according to claim 3, wherein the wall breaking in the step (4) is performed twice, the rotating speed of the wall breaking machine is 5800r/min for each wall breaking, and the wall breaking time is 30s for each wall breaking.
8. The method for preparing a dietary composition for post-operation of tumor patients and patients undergoing radiotherapy and chemotherapy according to claim 3, wherein the pressure for homogenization in step (5) is 100-600MPa, and the homogenization time is 10-15 min.
9. The preparation method of a dietetic composition for postoperative treatment of tumor patients and patients undergoing radiotherapy and chemotherapy according to claim 3, wherein the pressure of the ultra-high pressure sterilization in the step (7) is 400-600 MPa, and the sterilization time is 10-30 min.
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| CN106473107A (en) * | 2015-09-01 | 2017-03-08 | 马峻林 | A kind of instant type composite edible mycopowder nutrient and preparation method thereof |
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Application publication date: 20210105 |