CN112166191A - 经修饰的寡核苷酸及使用方法 - Google Patents
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- CN112166191A CN112166191A CN201980034104.5A CN201980034104A CN112166191A CN 112166191 A CN112166191 A CN 112166191A CN 201980034104 A CN201980034104 A CN 201980034104A CN 112166191 A CN112166191 A CN 112166191A
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/005—Enzyme inhibitors
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2320/00—Applications; Uses
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- C12Y—ENZYMES
- C12Y201/00—Transferases transferring one-carbon groups (2.1)
- C12Y201/01—Methyltransferases (2.1.1)
- C12Y201/01062—Methyltransferases (2.1.1) mRNA (2'-O-methyladenosine-N6-)-methyltransferase (2.1.1.62)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862646901P | 2018-03-22 | 2018-03-22 | |
| US62/646901 | 2018-03-22 | ||
| PCT/US2019/023463 WO2019183417A1 (en) | 2018-03-22 | 2019-03-21 | Modified oligonucleotides and methods of use |
Publications (1)
| Publication Number | Publication Date |
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| CN112166191A true CN112166191A (zh) | 2021-01-01 |
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| CN201980034104.5A Pending CN112166191A (zh) | 2018-03-22 | 2019-03-21 | 经修饰的寡核苷酸及使用方法 |
Country Status (7)
| Country | Link |
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| US (1) | US20210015884A1 (https=) |
| EP (1) | EP3768840A1 (https=) |
| JP (1) | JP2021518372A (https=) |
| CN (1) | CN112166191A (https=) |
| CA (1) | CA3094508A1 (https=) |
| MA (1) | MA52132A (https=) |
| WO (1) | WO2019183417A1 (https=) |
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| WO2022013420A1 (en) * | 2020-07-17 | 2022-01-20 | European Molecular Biology Laboratory | Prognostic biomarkers for cancer |
| CN116555325A (zh) * | 2023-04-11 | 2023-08-08 | 内蒙古农业大学 | 本氏烟m6A甲基化酶基因在抗病毒中的应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017075451A1 (en) * | 2015-10-28 | 2017-05-04 | The Broad Institute Inc. | Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1 |
| CN107349217A (zh) * | 2017-07-21 | 2017-11-17 | 深圳大学 | 一种基于mettl3的小干扰rna及其药物和应用 |
-
2019
- 2019-03-21 WO PCT/US2019/023463 patent/WO2019183417A1/en not_active Ceased
- 2019-03-21 JP JP2020550071A patent/JP2021518372A/ja active Pending
- 2019-03-21 EP EP19718493.0A patent/EP3768840A1/en not_active Withdrawn
- 2019-03-21 CA CA3094508A patent/CA3094508A1/en active Pending
- 2019-03-21 CN CN201980034104.5A patent/CN112166191A/zh active Pending
- 2019-03-21 MA MA052132A patent/MA52132A/fr unknown
- 2019-03-21 US US17/040,029 patent/US20210015884A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017075451A1 (en) * | 2015-10-28 | 2017-05-04 | The Broad Institute Inc. | Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1 |
| CN107349217A (zh) * | 2017-07-21 | 2017-11-17 | 深圳大学 | 一种基于mettl3的小干扰rna及其药物和应用 |
Non-Patent Citations (3)
| Title |
|---|
| DAVID G. COURTNEY等: "Epitranscriptomic Enhancement of Influenza A Virus Gene Expression and Replication", 《CELL HOST & MICROBE》, vol. 22, pages 384 - 385 * |
| KOSUKE TAKETO等: "The epitranscriptome m6A writer METTL3 promotes chemo- and radioresistance in pancreatic cancer cells", 《INTERNATIONAL JOURNAL OF ONCOLOGY》, vol. 52, pages 624 * |
| XIANG WANG等: "Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex", 《NATURE》, vol. 534, pages 2 - 4 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3768840A1 (en) | 2021-01-27 |
| CA3094508A1 (en) | 2019-09-26 |
| MA52132A (fr) | 2021-01-27 |
| JP2021518372A (ja) | 2021-08-02 |
| US20210015884A1 (en) | 2021-01-21 |
| WO2019183417A1 (en) | 2019-09-26 |
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