CN112156023B

CN112156023B - Cleansing gel and preparation method thereof

Info

Publication number: CN112156023B
Application number: CN202011220687.1A
Authority: CN
Inventors: 陈嘉文; 李传茂; 林盛杰; 张伟杰; 曾伟丹; 张楚标
Original assignee: Guangdong Danz Group Co Ltd; Guangzhou Keneng Cosmetic Research Co Ltd
Current assignee: Guangdong Danz Group Co Ltd; Guangzhou Keneng Cosmetic Research Co Ltd
Priority date: 2020-11-05
Filing date: 2020-11-05
Publication date: 2023-06-02
Anticipated expiration: 2040-11-05
Also published as: CN112156023A

Abstract

The invention provides a cleansing gel and a preparation method thereof. The cleansing gel comprises the following components in percentage by weight: humectant: 0.1-20%; and (3) a thickening agent: 0.5-5%; neutralizing agent: 0.01-2%; and (2) a surfactant: 0.1-10%; skin conditioning agent: 0.1-8%; active ingredients: 0.01-1%; and (3) preservative components: 0.1-2%; solubilizer: 0-5%; chelating agent: 0-0.5%; essence: 0-0.4%; wherein the surfactant comprises PEG-8 caprylic/capric glycerides and/or olive oil PEG-7 esters; the antiseptic component is mixture of lauroyl arginine ethyl ester hydrochloride and glycerol. The cleansing gel disclosed by the invention can be rapidly spread on the greasy dirt cleansing surface, is easy to clean, is moist and not greasy after being used, and achieves multiple skin care effects of moisturizing, protecting, exfoliating, resisting pollution and the like while carrying out gentle cleansing.

Description

Cleansing gel and preparation method thereof

Technical Field

The invention relates to a cleansing gel and a preparation method thereof, belonging to the field of cosmetics.

Background

With the increasing popularity of sun protection, isolation and make-up products, the conventional cleansing products have failed to meet the cleaning needs of users prior to daily skin care, and the demands of make-up removal products have increased. Especially, after the popularization of the makeup, the frequency of using the makeup by users is increased, the variety of the used makeup products is increased, the waterproof and anti-removal effects of the products are integrally enhanced, and the demands of the users on the makeup removal products are further increased.

In 2018, the sound volume of "makeup removal" in the whole-net range is 37.7% higher than that in 2017, and is relatively smooth in the year, and the discussion of "makeup removal" by users has begun to be daily. The cleansing products are mainly used for cleansing cosmetics, but are belonging to the category of skin care products. Make-up removal is the first step of daily skin care procedures, and generally, before ordinary cleansing, intractable make-up which cannot be completely removed by ordinary cleansing cream such as sunscreens, foundations, eye shadows, lipsticks, mascaras and the like is removed. The makeup removal is an important link of beauty and skin care, and if the makeup removal is incomplete, pores can be blocked on the residual face of the cosmetic, so that the consequence is serious.

The cleansing products are mainly divided into 5 types according to the textures, namely cleansing oil, cleansing cream, cleansing gel (gel) and cleansing water (liquid). The cleansing gel commonly used in the market can be free of oily components, and the use feeling is very fresh; the cleansing gel has weak fluidity, good use feeling and certain exfoliating effect; according to different formulas, the cleansing powder and the mildness are different, the cleansing powder is usually used for removing the light makeup, the daily use effect is good, and the cleansing powder is popular with consumers. However, cleansing power and mildness of the cleansing gel are always a problem that is difficult to balance, and low-tolerance skin is not suitable for long-term use.

Compared with cleansing liquid, cleansing cream and cleansing oil; the cleansing gel has the best use feeling, and has no need of being matched with cleansing cotton due to good fluidity like cleansing water, and has no need of being greasy and further cleaned after being used like cleansing oil; the cleaning is further carried out after the use by lifting with the help of a stick and a spoon like the makeup removing cream; the research of the cleansing gel technology is also mature, and the cleansing power and mildness are the problems, so that the skin care consciousness of users is further enhanced, and the proportion of people with low-tolerance skin is continuously increased. The enhanced skin care awareness of users encourages users to prefer mild cleansing products; the low-tolerance skin users worry that the makeup removing cotton matched with the makeup removing water is further worn on the cuticle, turn to other makeup removing categories, try to better consider the 'mild' and the 'cleaning power', and meet the requirements of users.

On the other hand, for the makeup removing gel formula system, most of the makeup removing gel adopts grease and a large amount of conventional preservative, surfactant and water, and the makeup removing gel has good makeup removing effect and antibacterial effect, a large amount of surfactant or conventional preservative is often added for pursuing excellent makeup removing effect, however, different surfactants or conventional preservatives can bring different irritation to skin, and meanwhile, the original conventional preservative of the formula system is added to reduce the mildness of the makeup removing gel.

There are many kinds of cleansing gels and methods for preparing them. For example, patent application 201410683413.4 provides a mild makeup removing gel for the lips and a preparation method thereof, wherein the makeup removing gel comprises oil-soluble components and water-soluble components, and the makeup removing gel for the lips is light in appearance, water-moist, mild in chemical property, and capable of thoroughly cleaning various makeup products, fresh and comfortable, and free from greasy feeling. However, the cleansing force of the eye and lip cleansing gel is general, and the cleansing effect is still not thorough.

Patent application document 201710504241.3 provides a makeup removing emulsion gel and a preparation method thereof, wherein the preparation method comprises the steps of firstly forming a ternary decontamination microcapsule coating body, then preparing microemulsion with squalane, and then forming a semitransparent makeup removing emulsion gel by using an acrylic resin stabilizing system. The cleansing gel has strong cleansing capability, high safety, small irritation to eyes, easy flushing, and moisturizing and non-greasy effects after use. However, the cleansing emulsion gel has poor mildness and is not suitable for long-term use for low-tolerance skin.

In addition, the formulations of both of the above patent application documents may contain conventional preservatives and fragrances which to some extent affect the mildness of the make-up removal gel or make-up removal cream gel.

In summary, research on a cleansing gel with both cleansing power and mildness is a technical problem to be solved.

Disclosure of Invention

Problems to be solved by the invention

In view of the technical problems in the prior art, the invention aims to balance the mildness and the cleaning force of the cleansing gel, ensure the stability, the safety and the effectiveness of a formula, reduce the irritation of the cleansing gel and simultaneously give consideration to the cleansing capability and the anti-corrosion effect.

Furthermore, the cleansing gel disclosed by the invention is mild in property, small in irritation to eyes, and capable of being rapidly spread on the turbid surface of oil-contaminated cleansing gel, easy to clean, and capable of removing old and waste cutin, and is moist and not greasy when being used, so that the effects of mild cleansing and multiple skin care are achieved.

Furthermore, the invention also provides a preparation method of the cleansing gel, which prepares the gel preform in advance, and further prepares the cleansing gel so that the efficacy of the cleansing gel can be effectively exerted to the greatest extent.

Solution for solving the problem

The invention provides a cleansing gel, which comprises the following components in percentage by mass:

humectant: 0.1-20%, preferably 0.2-15%;

and (3) a thickening agent: 0.5-5%, preferably 0.5-2%;

neutralizing agent: 0.01-2%, preferably 0.1-1.8%;

and (2) a surfactant: 0.1-10%, preferably 1-9%;

skin conditioning agent: 0.1-8%, preferably 0.1-3%;

active ingredients: 0.01-1%, preferably 0.1-0.5%;

and (3) preservative components: 0.1-2%, preferably 0.5-1.5%;

solubilizer: 0-5%, preferably 1-4%;

chelating agent: 0-0.5%, preferably 0.01-0.2%;

essence: 0-0.4%, preferably 0.01-0.3%; wherein,,

the surfactant comprises PEG-8 caprylic/capric glyceride and/or olive oil PEG-7 ester;

the antiseptic component is mixture of lauroyl arginine ethyl ester hydrochloride and glycerol.

The cleansing gel according to the present invention, wherein the amount of the lauroyl arginine ethyl ester hydrochloride added is 10 to 30% and the amount of the glycerin added is 70 to 90% based on the total mass of the mixture of lauroyl arginine ethyl ester hydrochloride and glycerin.

The cleansing gel according to the present invention, wherein the active ingredient comprises oat β -glucan.

The make-up removal gel of the present invention wherein the skin conditioning agent comprises ethoxydiglycol.

The cleansing gel according to the present invention, wherein the thickener comprises one or a combination of two or more of carbomers, acrylic acid (esters) and/or C10-30 alkyl acrylate cross-linked polymers and acrylic acid (esters) copolymers.

The cleansing gel according to the present invention, wherein the humectant comprises a polyhydric alcohol, preferably, the polyhydric alcohol comprises one or a combination of two or more of 1, 3-propanediol, 1, 2-hexanediol, 1, 2-pentanediol, 1, 2-propanediol, glycerol, 1, 3-butanediol, and sorbitol.

The cleansing gel according to the present invention, wherein the neutralizing agent comprises an alkaline agent, preferably, the alkaline agent comprises one or a combination of two or more of potassium hydroxide, sodium hydroxide and triethanolamine.

The cleansing gel according to the present invention, wherein the solubilizing agent comprises one or a combination of two or more of PEG-40 hydrogenated castor oil, polysorbate-20, and PPG-26-butanol polyether-26; and/or

The chelating agent comprises disodium EDTA and/or tetrasodium EDTA.

The invention also provides a preparation method of the cleansing gel, which comprises the step of mixing the components of the cleansing gel.

The preparation method of the cleansing gel comprises the following steps:

mixing water, optionally a chelating agent, a portion of a humectant, a thickening agent, a neutralizing agent to produce a gel preform;

adding surfactant, remaining humectant and skin conditioning agent to the gel preform to obtain a primary mixture;

a preservative ingredient, an active ingredient, optionally a solubilizing agent, and optionally a fragrance are added to the initial mixture to provide a make-up removal gel.

ADVANTAGEOUS EFFECTS OF INVENTION

The cleansing gel of the present invention has at least one of the following effects:

(1) The cleansing gel disclosed by the invention can be rapidly spread on the greasy dirt cleansing surface, is easy to clean, is moist and not greasy after being used, and achieves multiple skin care effects of moisturizing, protecting, exfoliating, resisting pollution and the like while carrying out gentle cleansing.

(2) The cleansing gel does not need to be added with other conventional preservatives, so that the irritation of the cleansing gel can be effectively reduced, and meanwhile, the cleansing capability and the preservative effect are achieved.

(3) The cleansing gel disclosed by the invention can effectively reduce the irritation and influence of cosmetics on the skin, is not easy to cause discomfort of facial skin, is mild, has no irritation, and is suitable for various skin people.

(4) The cleansing gel disclosed by the invention can promote moisture absorption and moisture metabolism of skin and promote the absorption of other effective components by the skin; make-up removal is carried out while repairing the susceptible skin of frequently used make-up removal products.

(5) The preparation method of the cleansing gel is simple and feasible, raw materials are easy to obtain, and the cleansing gel is suitable for mass production.

Drawings

Figure 1 shows the average skin moisture content of a 0.1% aqueous hyaluronic acid solution and a cleansing gel of example 5 of the present invention applied to the arm of a subject at various time points.

Detailed Description

The following describes the present invention in detail. The following description of the technical features is based on the representative embodiments and specific examples of the present invention, but the present invention is not limited to these embodiments and specific examples. It should be noted that:

in the present specification, the numerical range indicated by the term "numerical value a to numerical value B" means a range including the end point numerical value A, B.

In the present specification, unless specifically stated otherwise, "a plurality" of "a plurality of" etc. means a numerical value of 2 or more.

In this specification, the terms "substantially", "substantially" or "substantially" mean that the error is less than 5%, or less than 3% or less than 1% compared to the relevant perfect or theoretical standard.

In the present specification, "%" means mass% unless otherwise specified.

In the present specification, the meaning of "can" includes both the meaning of performing a certain process and the meaning of not performing a certain process.

In this specification, "optional" or "optionally" means that the subsequently described event or circumstance may or may not occur, and that the description includes instances where the event occurs and instances where it does not.

Reference throughout this specification to "some specific/preferred embodiments," "other specific/preferred embodiments," "an embodiment," and so forth, means that a particular element (e.g., feature, structure, property, and/or characteristic) described in connection with the embodiment is included in at least one embodiment described herein, and may or may not be present in other embodiments. In addition, it is to be understood that the elements may be combined in any suitable manner in the various embodiments.

< first aspect >

The first aspect of the invention provides a makeup removing gel, which comprises the following components in terms of total mass of the makeup removing gel:

humectant: 0.1-20%, preferably 0.2-15%;

and (3) a thickening agent: 0.5-5%, preferably 0.5-2%;

neutralizing agent: 0.01-2%, preferably 0.1-1.8%;

and (2) a surfactant: 0.1-10%, preferably 1-9%;

skin conditioning agent: 0.1-8%, preferably 0.1-3%;

active ingredients: 0.01-1%, preferably 0.1-0.5%;

and (3) preservative components: 0.1-2%, preferably 0.5-1.5%;

solubilizer: 0-5%, preferably 1-4%;

chelating agent: 0-0.5%, preferably 0.01-0.2%;

essence: 0-0.4%, preferably 0.01-0.3%; wherein,,

The cleansing gel achieves multiple skin care effects of moisturizing, protecting, exfoliating, resisting pollution and the like while mildly cleansing. Specifically:

humectant type

The cleansing gel disclosed by the invention needs to be added with a certain amount of moisturizing agents, so that the cleansing gel has a moisturizing effect. Specifically, in the present invention, the humectant is added in an amount of 0.1 to 20%, preferably 0.2 to 15%, based on the total mass of the cleansing gel. When the addition amount of the humectant is less than 0.1%, the moisturizing effect cannot be achieved; if the amount of the humectant is more than 20%, the cleansing gel becomes too moist and sticky, and the cost increases. Specifically, in the present invention, the humectant is added in an amount of 2%, 4%, 6%, 8%, 10%, 12%, 14%, 16%, 18%, etc.

In some specific embodiments, the humectant comprises a polyol, preferably the polyol comprises one or a combination of two or more of 1, 3-propanediol, 1, 2-hexanediol, 1, 2-pentanediol, 1, 2-propanediol, glycerol, 1, 3-butanediol, sorbitol.

Preferably, in the present invention, the humectant comprises sorbitol. Sorbitol is a small molecule hydrophilic humectant extracted from fruits, seaweed or chemically changing glucose. The sorbitol is added in the invention, which not only has the function of moisturizing, but also can further help the cleansing gel to be in gel state due to the appearance characteristic. Further, in the present invention, the addition amount of sorbitol is 0.08 to 15%, preferably 5 to 12%, based on the total mass of the makeup removing gel, and the cold resistance of the makeup removing gel is facilitated when the addition amount of sorbitol is 0.08 to 12%, and particularly, the makeup removing gel is not coagulated into a solid state even under low temperature conditions when the addition amount of sorbitol is 5 to 12%.

Thickening agent

According to the invention, by adding some thickening agents, the high-temperature stability of the cleansing gel can be effectively improved, and the spreadability of the material body and the use feeling of consumers are affected. In the present invention, the thickener is added in an amount of 0.5 to 5%, preferably 0.5 to 2%, based on the total mass of the cleansing gel. When the addition amount of the thickener is less than 0.5%, the corresponding effect cannot be achieved; if the addition amount of the thickener is more than 5%, the cleansing gel becomes too viscous and does not form gel texture any more, and spreadability is poor. Specifically, in the present invention, the thickener is added in an amount of 1%, 1.5%, 2.5%, 3%, 3.5%, 4%, 4.5%, etc.

In some specific embodiments, the thickener comprises one or a combination of two or more of carbomers, acrylic acid (esters) based/C10-30 alkanol acrylate cross-linked polymers, acrylic acid (esters) based copolymers.

Neutralizing agent

According to the invention, the pH value of the cleansing gel is adjusted by adding a certain neutralizing agent so as to enable the cleansing gel to be closer to the pH value of skin, so that the efficacy of the cleansing gel can be exerted to the greatest extent. Specifically, the neutralizing agent is added in an amount of 0.01 to 2%, preferably 0.1 to 1.8% based on the total mass of the cleansing gel. When the content of the neutralizing agent is less than 0.01%, the effect of adjusting the pH value cannot be achieved, and when the content of the neutralizing agent is more than 2%, the content is too high, resulting in the final pH value of the product being too high, which may increase the irritation to the skin and cause allergic reaction. Specifically, in the present invention, the addition amount of the neutralizing agent is 0.2%, 0.4%, 0.6%, 0.8%, 1%, 1.2%, 1.4%, 1.6%, etc.

In some specific embodiments, the neutralizing agent comprises an alkaline agent, preferably the alkaline agent comprises one or a combination of two or more of potassium hydroxide, sodium hydroxide, and triethanolamine.

Surface active agent

The functional component for finishing makeup removal is a surfactant. The surfactant has the property of mixing oil and water, and is used for reducing the surface tension of the liquid, thereby achieving the aim of cleaning. Specifically, in the present invention, the surfactant is added in an amount of 0.1 to 10%, preferably 1 to 9%, based on the total mass of the cleansing gel. When the content of the surfactant is less than 0.1%, the cleansing effect cannot be achieved, and when the content of the surfactant is more than 10%, the sebum and horny layer state may be affected by long-term use. Specifically, in the present invention, the surfactant is added in an amount of 2%, 3%, 4%, 5%, 6%, 7%, 8%, etc.

Further, in order to give the most effective play to the cleansing efficacy of the surfactant of the present invention, and to achieve a mild performance while reducing the irritation of the cleansing gel, the cleansing gel of the present invention comprises PEG-8 caprylic/capric glycerides and/or olive oil PEG-7 esters, while achieving a good preservation ability. The inventor of the invention discovers that the use of PEG-8 caprylic/capric glyceride and/or olive oil PEG-7 ester can further reduce the irritation of the cleansing gel and simultaneously compromise the antiseptic capability compared with similar products; and the PEG-8 caprylic/capric glyceride and/or olive oil PEG-7 ester are used as the surfactant, so that the cleansing capability is higher, and the cleansing effect is better for mascara and the like which are difficult to clean.

Preferably, the surfactants of the present invention include PEG-8 caprylic/capric glycerides and olive oil PEG-7 esters. The addition amount of the PEG-8 caprylic/capric glyceride is 0.09-7% based on the total mass of the cleansing gel, and the addition amount of the olive oil PEG-7 ester is 0.01-2%.

Skin conditioning agent

The invention enables the efficacy of the cleansing gel of the invention to be exerted to a greater extent by the addition of skin conditioning agents. Specifically, in the present invention, the skin conditioning agent is added in an amount of 0.1 to 8%, preferably 0.1 to 3%, based on the total mass of the cleansing gel. When the content of the skin conditioning agent is less than 0.1%, the corresponding effect cannot be achieved, and when the content of the skin conditioning agent is more than 8%, the content is too high, so that the makeup removing effect of the makeup removing gel is affected. Specifically, the skin conditioning agent is added in an amount of 0.5%, 1%, 2%, 2.5%, 3.5%, 4.5%, 5.5%, 6.5%, 7.5%, etc.

Further, the skin conditioning agent of the present invention comprises ethoxydiglycol. The invention uses the ethoxydiglycol as the skin conditioner, can lead the cell arrangement on the surface of the skin to be temporarily flocculated, has good permeability and extremely excellent dissolution performance, and can further improve the cleansing ability of the cleansing gel.

Active ingredient

The invention also contains active ingredients to improve the repair and antiallergic ability of the skin. Specifically, the active ingredient is added in an amount of 0.01 to 1%, preferably 0.1 to 0.5% by weight based on the total mass of the cleansing gel. When the content of the active ingredient is less than 0.01%, the corresponding effect cannot be achieved, and when the content of the active ingredient is more than 1%, the cost is excessively high. Specifically, the addition amount of the active ingredient is 0.2%, 0.3%, 0.4%, 0.6%, 0.7%, 0.8%, 0.9%, etc.

In some specific embodiments, the active ingredient comprises oat β -glucan. Oat beta-glucan is a natural non-starch water-soluble plant sugar existing in large oat skin, and can accelerate the determination of immune cells of a population, lighten the reaction of bacterial infection, control the position of the bacterial infection and recover the infected surface as soon as possible; has effects in promoting collagen synthesis by fibroblast, promoting wound healing, repairing damaged skin, and providing skin with silky and smooth touch.

In addition, oat beta-glucan can improve the antiallergic capability of skin, activate immune function, moisturize skin, delay skin aging and the like. All of its effects are due to activation of macrophages. It is well known that macrophages are not only non-specific cytotoxins for malignant cells, but also attract immunocompetent cells and other white blood cells, thereby promoting wound healing and normal tissue production. Although macrophage membrane receptors have been isolated, the mechanism of macrophage activation is not completely understood. Oat beta-glucan is well recognized by macrophages and promotes macrophage proliferation, possibly due to its specific planar helical stereochemical structure. Thus, the present invention preferably uses oat β -glucan as an active ingredient.

Preservative composition

The cleansing gel of the present invention has excellent anti-corrosion ability by using the anti-corrosion ingredient. Specifically, in the present invention, the preservative component is added in an amount of 0.1 to 2%, preferably 0.5 to 1.5% based on the total mass of the cleansing gel. When the content of the preservative is less than 0.1%, the corresponding effect cannot be achieved, and when the content of the active ingredient is more than 2%, the skin irritation is great. Specifically, the addition amount of the preservative component is 0.2%, 0.4%, 0.6%, 0.8%, 1%, 1.2%, 1.4%, 1.6%, 1.8%, etc.

Further, the preservative component of the invention is a mixture of lauroyl arginine ethyl ester hydrochloride and glycerin. Wherein lauroyl arginine ethyl ester hydrochloride has high antibacterial activity, the melting point is 50-58 ℃, and the partition coefficient in water and oil is more than 10, namely the lauroyl arginine ethyl ester hydrochloride mainly exists in an aqueous phase. Compared with other preservatives with different chemical structures and similar functions, the lauroyl arginine ethyl ester hydrochloride can be more conveniently dissolved into food and cosmetic systems with water matrixes, and better plays a role in bacteriostasis. Lauroyl arginine ethyl ester hydrochloride has good antibacterial effect on gram-positive bacteria, gram-negative bacteria, pathogens, yeasts and moulds, pathogenic escherichia coli, beer yeast, aspergillus niger, listeria and the like, and is a safe and efficient antiseptic antibacterial product.

Further, the present invention uses a mixture of lauroyl arginine ethyl ester hydrochloride and glycerin as a preservative ingredient, and lauroyl arginine ethyl ester hydrochloride is a white powder, which is very easily dissolved in glycerin. The inventor finds that the glycerol is used as a solvent to be pretreated and then is conveniently and directly added into a formula, and meanwhile, the glycerol has certain viscosity, so that the glycerol is easy to produce, store and use after being mixed with lauroyl arginine ethyl ester hydrochloride.

In some specific embodiments, the amount of lauroyl arginine ethyl ester hydrochloride added is 10-30% based on the total mass of the mixture of lauroyl arginine ethyl ester hydrochloride and glycerin, the amount of glycerin added is 70-90%, the amount of lauroyl arginine ethyl ester hydrochloride added is less than 10%, and when the amount of glycerin added is greater than 90%, the mixture has poor preservative effect and sticky skin feel; when the adding amount of lauroyl arginine ethyl ester hydrochloride is more than 30% and the adding amount of glycerol is less than 70%, the stability of the mixture is not good enough and the irritation is strong. When the adding amount of lauroyl arginine ethyl ester hydrochloride is 10-30% and the adding amount of glycerin is 70-90%, the preservative, skin feel, safety and stability can be well considered. Specifically, the adding amount of the lauroyl arginine ethyl ester hydrochloride is 12%, 15%, 18%, 20%, 22%, 25%, 28% and the like. The glycerol is added in an amount of 72%, 75%, 78%, 80%, 82%, 85%, 88%, etc.

Other ingredients

Other ingredients may also be included in the make-up removing gel of the present invention. In particular, the other ingredients may be any viable ingredients in cosmetics, such as chelating agents, solubilizers, fragrances, solvents, and the like. Specifically, in the present invention, the addition amount of the solubilizer is 0 to 5%, preferably 1 to 4%; the chelating agent is added in an amount of 0-0.5%, preferably 0.01-0.2%; the addition amount of the essence is 0-0.4%, preferably 0.01-0.3%. Specifically, the chelating agent may be disodium EDTA and/or tetrasodium EDTA, or the like. The solubilizer comprises one or more than two of PEG-40 hydrogenated castor oil, polysorbate-20, tween-80 and PPG-26-butanol polyether-26. The content of the solvent is not particularly limited, and the solvent may be added according to specific needs, and the solvent may be water in general.

In a second aspect, the present invention provides a method for preparing the cleansing gel of the first aspect, which comprises the step of mixing the components of the cleansing gel.

Further, the preparation method of the invention comprises the following steps:

Specifically, the preparation method comprises the following steps:

placing water, optionally chelating agent, part of humectant and thickener into emulsifying pot, stirring and heating to 75-85deg.C;

adding the dissolved neutralizing agent into the emulsifying pot, and stirring the mixture at a constant temperature until a gel preform is formed.

Preparing a liquid mixture (prefabricated liquid) from a surfactant, the rest humectant and the skin conditioner, putting into an emulsifying pot, stirring uniformly, and cooling to 36-45 ℃;

uniformly stirring the antiseptic component, the active component, the optionally-existing solubilizer and the optionally-existing essence, and then putting into an emulsifying pot, and uniformly stirring;

continuously stirring and cooling. And (5) after the temperature is reduced to below 35 ℃ for inspection, discharging through a filter screen after the inspection is qualified.

The method of the invention adopts the steps of preparing the hydrogel prefabricated system, adding the makeup removing component, the skin conditioning agent and the like, and finally adding other components such as essence and active components, thereby preparing the makeup removing gel with excellent performance.

Examples

Embodiments of the present invention will be described in detail below with reference to examples, but it will be understood by those skilled in the art that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention. The specific conditions are not noted in the examples and are carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or apparatus used were conventional products commercially available without the manufacturer's attention.

In the embodiment of the invention, the proportion of each component adopts weight percentage, and can be the content unit which is known in the medicine field such as mu g, mg, g, kg and the like.

Wherein, the manufacturer of PEG-8 caprylic acid/capric acid glyceride is Sanji oil Co., ltd;

the manufacturers of olive oil PEG-7 esters are available from Shandor New Material technology (Suzhou);

the manufacturer of lauroyl arginine ethyl ester hydrochloride is the chemical company of the Beijing-shaped lion.

Examples 1 to 5

The cleansing gels of examples 1 to 5 were prepared according to the following methods, based on the weight percentages of the components of examples 1 to 5 in table 1 below, based on 100% by total weight.

The preparation method of the cleansing gel of examples 1 to 5 comprises the following steps:

1. and (3) putting the phase A into an emulsifying pot, stirring and heating to 82 ℃ until all the components are completely uniform. The temperature was maintained at 82 ℃.

2. And (3) putting the dissolved B phase into an emulsifying pot, and carrying out heat preservation and stirring until a uniform gel preform is formed.

3. Preparing the prefabricated liquid before using the C phase, then putting the prefabricated liquid into an emulsifying pot, and stirring the prefabricated liquid until the prefabricated liquid is uniform.

4. And opening cooling water to cool to 42 ℃.

5. Sequentially adding the phase D into an emulsifying pot, and stirring until the mixture is uniform.

6. Stirring phase E uniformly, adding into emulsifying pot, and stirring uniformly.

7. Continuously stirring and cooling. And (5) after the temperature is reduced to below 35 ℃ for inspection, discharging through a filter screen after the inspection is qualified.

Wherein, in the mixture of lauroyl arginine ethyl ester hydrochloride and glycerin used in the examples, the content of lauroyl arginine ethyl ester hydrochloride was 20% and the content of glycerin was 80% based on the total mass of the mixture of lauroyl arginine ethyl ester hydrochloride and glycerin.

TABLE 1

Comparative example 1

The mixture of 1% ethyl lauroyl arginine hydrochloride and glycerin in example 1 was replaced with 0.2% methylparaben and 0.8% water in phase a, with the remainder being exactly the same as in example 1.

Comparative example 2

The mixture of 1% ethyl lauroyl arginine hydrochloride and glycerin in example 1 was replaced with 0.8% phenoxyethanol and 0.2% water in phase a, all other things being identical to example 1.

Comparative example 3

The mixture of 1% ethyl lauroyl arginine hydrochloride and glycerin in example 1 was replaced with 0.15% ethylhexyl glycerin and 0.85% water in phase a, all other things being identical to example 1.

Comparative example 4

The mixture of 1% ethyl lauroyl arginine hydrochloride and glycerin in example 1 was replaced with 0.3% polyaminopropyl biguanide and 0.7% water in phase a, the other being exactly the same as in example 1.

Comparative example 5

The mixture of 1% ethyl lauroyl arginine hydrochloride and glycerin in example 1 was replaced with 0.15% epsilon-polylysine and 0.85% water in phase a, with the remainder being exactly the same as in example 1.

Comparative example 6

4% of PEG-8 caprylic/capric glycerides and 2% of olive oil PEG-7 esters of example 3 were replaced with 2% of poloxamer 184 and 4% of water in phase A, the other being exactly the same as example 3.

Comparative example 7

4% of PEG-8 caprylic/capric glycerides and 2% of olive oil PEG-7 esters of example 3 were replaced with 6% of PEG-6 caprylic/capric glycerides, the other being exactly the same as example 3.

Comparative example 8

The 4% PEG-8 caprylic/capric glycerides and 2% olive oil PEG-7 esters of example 3 were replaced with 1% poloxamer 184 and 5% PEG-6 caprylic/capric glycerides, the others being exactly the same as example 3.

Comparative example 9

The 4% PEG-8 caprylic/capric glycerides and 2% olive oil PEG-7 esters of example 3 and 0.5% water in phase A were replaced with 6% PEG-6 caprylic/capric glycerides and 0.5% olive oil PEG-7 esters, the others being exactly the same as example 3.

Performance testing

1. Mild evaluation

About 2g of the cleansing gel of examples 1 to 4 and comparative examples 1 to 9 was gently rubbed along the facial skin texture, followed by washing with clear water, and the mildness of use was evaluated at the time of use.

Each time an equal weight of make-up removal gel is used; the mildness of each cleansing gel was evaluated by 10 panelists and scored according to the following 4-level evaluation criteria (table 2). The determination was made according to the average scores of the makeup-removing gels of examples 1 to 4 and comparative examples 1 to 9, according to the following 4-level evaluation criteria (table 3).

Table 24 level evaluation criteria

Score of	4	3	2	1
					Evaluation	Excellent in	Good quality	In general	Slightly inferior

Table 34 level judgment standard

Average score	≥4.0	3.0-4.0	1.5-3.0	≤1.5
					Judging	Excellent in	Good quality	In general	Slightly inferior

Specifically, the mildness of the cleansing gel was scored by the above method, with the highest score of 5 and the lowest score of 0, and the average score was determined. Different grades of the judgment criteria were obtained from the average scores, and the results are shown in table 4 below.

TABLE 4 Table 4

As can be seen from Table 4, the mildness of the cleansing gels of examples 1 to 4 was more excellent than that of comparative examples 1 to 9.

The mildness evaluation results of examples 1 to 2 were excellent, the mildness evaluation results of comparative examples 1 to 2 were general, the mildness evaluation results of comparative examples 3 to 4 were slightly inferior, and the mildness evaluation results of comparative example 5 were good, and therefore, the preservative composition of the present invention was able to effectively reduce the irritation of the cleansing gel.

The mildness evaluation results of examples 3 to 4 were excellent, the mildness evaluation results of comparative examples 6, 7 and 9 were good, and the mildness evaluation result of comparative example 8 was slightly worse; therefore, the PEG-8 caprylic/capric glyceride and/or olive oil PEG-7 ester selected by the invention is used as the surfactant, so that the irritation of the cleansing gel can be effectively reduced.

2. Microbial preservative efficacy test

The test was performed with reference to the USP32 (51) microbial preservative efficacy test. The detection method comprises the following steps: 100g of the makeup removing gel samples of examples 1 to 5 and the makeup removing gel samples of comparative examples 1 to 5 were weighed and tested, respectively, the inoculation and sterilization operation was performed on the 0 th day of the test, and the bacterial contents in the samples were analyzed by sampling on the 7 th, 14 th and 28 th days after the sterilization, respectively, and the test results were shown in the following table 5:

TABLE 5

Table 5 (subsequent)

Wherein the test strain: purchased from the Guangdong province institute of microorganisms

Bacteria: staphylococcus aureus (staphylococcus aureus): ATCC6538

Coli (Escherchia coli): ATCC8739

Pseudomonas aeruginosa (Pseudomonas aeruginosa): ATCC9027

Mould and yeast: aspergillus niger (Aspergillus niger): ATCC16404

Candida albicans (Candida albicans): ATCC10231

After counting, according to the CTFA standard, the bacteria are required to be reduced by 99.9 percent on the 7 th day, the mold and the saccharomycetes are respectively reduced by 90 percent, and the bacteria continuously drop in 28 days, and the antiseptic effect is judged to pass, so that the cleansing gel has good antibacterial effect. Otherwise, the microbial preservation challenge test does not pass.

As can be seen from Table 5, the microbial preservative challenge of comparative examples 1-5 was not passed and the preservative effect was poor. The cleansing gel of the embodiments 1-5 can pass the microbial antiseptic challenge experiment, and the irritation of the cleansing gel can be reduced.

Applicants also conducted a microbial preservative efficacy test on comparative examples 6-9, which passed the microbial preservative challenge test, however, it can be seen from the above mildness test that the use of the surfactants of comparative examples 6-9 did not compromise the reduction of the irritation of the make-up removal gel.

3. Evaluation of cleansing Effect

10 women with healthy subjects were selected and the cleansing power of the mascara-removing gels prepared in examples 3 to 4 and comparative examples 6 to 9 on mascaras and lipsticks was evaluated. The cosmetic is prepared by 10 minutes, the cosmetic removing effect is good by 10 minutes, the cosmetic is 9 minutes, and the cosmetic is the worst by 1 minute. The test results are shown in Table 6.

TABLE 6

As can be seen from Table 6, according to the test results, the cleansing gels prepared in examples 3 to 4 and comparative examples 6 to 9 of the present invention all had cleansing power to lipstick, but examples 3 to 4 had more cleansing power to lipstick; the cleansing gel prepared in example 3 and example 4 provides better cleansing effect for hard-to-clean mascara.

4. Moisture efficacy test

Test sample: make-up removal gel example 5 and hyaluronic acid 0.1% aqueous solution.

The testing method comprises the following steps: 30 subjects with healthy skin, no history of skin disease and allergy were randomly selected, and the appropriate area of the upper flexor lateral zone of the subject was selected as the test zone. The tested area is cleaned by clear water before testing, then is evenly wiped by alcohol and naturally dried for 15min, and a skin moisture measuring device is used for measuring skin moisture

CM 825 skin tester) to determine the average skin moisture content (blank value) before the sample was applied. Two samples of 30. Mu.L were applied to the inner side of the forearm of the subject in a range of 3 cm. Times.3 cm, respectively, and after completely and uniformly applying the sample to the inner side of the forearm with fingers. Skin moisture content after 5 minutes, 30 minutes, 1 hour, 2 hours after application was measured with a skin moisture meter, and the average skin moisture content at each time point of the two samples was compared, and test data are shown in table 7 and fig. 1 below:

table 12: average skin moisture content of subject arm at various time points

As can be seen from table 7, the results show that the average skin water content after the makeup removing gel is applied to the sample is slightly higher than the average skin water content value after the hyaluronic acid 0.1% aqueous solution is applied, which indicates that the makeup removing gel has better moisturizing effect.

It should be noted that, although the technical solution of the present invention is described in specific examples, those skilled in the art can understand that the present invention should not be limited thereto.

The foregoing description of embodiments of the invention has been presented for purposes of illustration and description, and is not intended to be exhaustive or limited to the embodiments disclosed. Many modifications and variations will be apparent to those of ordinary skill in the art without departing from the scope and spirit of the various embodiments described. The terminology used herein was chosen in order to best explain the principles of the embodiments, the practical application, or the technical improvements in the marketplace, or to enable others of ordinary skill in the art to understand the embodiments disclosed herein.

Claims

1. A make-up removal gel, characterized in that it comprises the following components, by total mass of the make-up removal gel:

humectant: 0.1-20%;

and (3) a thickening agent: 0.5-5%;

neutralizing agent: 0.01-2%;

and (2) a surfactant: 0.1-9%;

skin conditioning agent: 0.1-8%;

active ingredients: 0.01-1%;

and (3) preservative components: 0.1-2%;

solubilizer: 0-5%;

chelating agent: 0-0.5%;

essence: 0-0.4%; wherein,,

the surfactant is PEG-8 caprylic acid/capric acid glyceride and olive oil PEG-7 ester, the addition amount of the PEG-8 caprylic acid/capric acid glyceride is 0.09-7% based on the total mass of the cleansing gel, and the addition amount of the olive oil PEG-7 ester is 0.01-2%;

the preservative component is a mixture of lauroyl arginine ethyl ester hydrochloride and glycerol;

the active ingredient comprises oat beta-glucan;

the skin conditioning agent comprises ethoxydiglycol.

2. The cleansing gel according to claim 1, characterized by comprising the following components, based on the total mass of the cleansing gel:

humectant: 0.2-15%;

and (3) a thickening agent: 0.5-2%;

neutralizing agent: 0.1-1.8%;

and (2) a surfactant: 1-9%;

skin conditioning agent: 0.1-3%;

active ingredients: 0.1-0.5%;

and (3) preservative components: 0.5-1.5%;

solubilizer: 1-4%;

chelating agent: 0.01-0.2%;

essence: 0.01-0.3%.

3. The cleansing gel according to claim 1 or 2, wherein the amount of the lauroyl arginine ethyl ester hydrochloride added is 10 to 30% and the amount of the glycerin added is 70 to 90% based on the total mass of the mixture of lauroyl arginine ethyl ester hydrochloride and glycerin.

4. The cleansing gel according to claim 1 or 2, wherein the thickener comprises one or a combination of two or more of carbomers, acrylic acid (esters) and C10-30 alkanol acrylate cross-linked polymers and acrylic acid (esters) copolymers.

5. The make-up removal gel of claim 1 or 2, wherein the moisturizer comprises a polyol.

6. The cleansing gel according to claim 5, wherein the polyhydric alcohol comprises one or a combination of two or more of 1, 3-propanediol, 1, 2-hexanediol, 1, 2-pentanediol, 1, 2-propanediol, glycerol, 1, 3-butanediol, sorbitol.

7. The make-up removal gel of claim 1 or 2, wherein the neutralizing agent comprises an alkaline agent.

8. The make-up removal gel of claim 7, wherein the alkaline agent comprises one or a combination of two or more of potassium hydroxide, sodium hydroxide, and triethanolamine.

9. The make-up removal gel of claim 1 or 2, wherein the solubilizing agent comprises one or a combination of two or more of PEG-40 hydrogenated castor oil, polysorbate-20, tween-80, and PPG-26-butanol polyether-26; and/or

The chelating agent comprises disodium EDTA and/or tetrasodium EDTA.

10. A method of preparing a make-up removal gel according to any one of claims 1 to 9, comprising the step of mixing the components of the make-up removal gel.

11. The method for preparing a cleansing gel according to claim 10, characterized in that it comprises:

mixing water, optionally a chelating agent, a portion of a humectant, a thickener, a neutralizing agent to produce a gel preform;

adding a preservative ingredient, an active ingredient, an optional solubilizer, and an optional essence to the initial mixture to obtain a make-up removal gel.