CN112138070A - Preparation method of traditional Chinese medicine for treating acute mastitis - Google Patents
Preparation method of traditional Chinese medicine for treating acute mastitis Download PDFInfo
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Abstract
The invention discloses a preparation method of a traditional Chinese medicine for treating acute mastitis, which comprises the following steps: s1: selecting raw materials: the composition comprises the following components in parts by weight: 10-14 parts of snakegourd fruit, 16-20 parts of red paeony root, 7-11 parts of weeping forsythia, 16-24 parts of dandelion, 8-12 parts of green tangerine peel, 4-8 parts of crucian carp, 4-8 parts of Japanese ampelopsis root, 6-10 parts of liquorice, 4-8 parts of saxifrage, 6-10 parts of Japanese cayratia herb, 6-10 parts of scutellaria baicalensis, 7-11 parts of great burdock achene, 8-12 parts of ricepaper pith, 4-8 parts of seaweed, 6-10 parts of fried cowherb seed and 4-8 parts of tangerine leaf. The preparation method is simple, the prepared traditional Chinese medicine has small toxic and side effects, is easy to absorb in the digestive tract, has short treatment course and high cure rate, and avoids rash, nausea, diarrhea, pseudomembranous enteritis and the like caused by adopting antibiotics; it can also relax middle energizer and lower qi to relieve chest stuffiness and dissipate nodulation, and glide down large intestine to moisten dryness and relax bowels, with the action of detumescence.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine preparation, in particular to a preparation method of a traditional Chinese medicine for treating acute mastitis.
Background
Acute mastitis is acute suppurative infection of mammary gland, is inflammation of connective tissue in and around the mammary gland, is frequently generated in postpartum lactating women, particularly more common in the early and puerperal women, most pathogenic bacteria of acute mastitis are staphylococcus aureus, drug resistance is frequently generated, secondary suppurative mastitis can be generated if the treatment is incorrect, western medicine treatment mainly takes antibiotics as main materials, anti-infective medicaments are frequently adopted in the aspect of treatment, and the first step is that penicillin is adopted: allergic reactions, especially anaphylactic shock (the most dangerous anaphylactic shock, which can occur during skin tests and rarely during continuous medication, the latter is called delayed anaphylactic shock), can be life-threatening if not rescued in time, and secondly, amoxicillin is adopted: occasionally rash, nausea, epigastric discomfort, diarrhea, pseudomembranous enteritis and the like after a large amount of oral administration; ③ adopting carbenicillin: various types of allergic reactions can occur, neurotoxic reactions and pulmonary edema can be caused after large dose administration, and transient transaminase rise and granulocytopenia can occur. Fourthly, adopting cephalothin: intramuscular injection has local pain, intravenous injection can have phlebitis, allergic reactions such as rash and the like can occur in a few cases, the intramuscular injection has certain damage to the liver and the kidney, the occasional leucopenia and the double infection can possibly generate drug resistance, and the intramuscular injection has certain toxic and side effects.
According to the traditional Chinese medicine, acute mastitis belongs to the field of acute mastitis, the nipple belongs to the liver, the breast belongs to the stomach, milk is sourced from the stomach, if liver qi is stagnated in the stomach, liver qi is uncomfortable, and the qi of jueyin is not allowed to flow so as to lose the function of smoothing flow, postpartum weakness and improper diet are added, so that liver qi stagnation and stomach heat are caused, milk can not be smoothly moved, qi stagnation and blood stasis are caused, heat toxin is accumulated in the interior to form carbuncle, and the toxic and side effects caused by using antibiotics are reduced, so that a traditional Chinese medicine preparation method for treating acute mastitis is provided.
Disclosure of Invention
Based on the technical problems in the background art, the invention provides a preparation method of a traditional Chinese medicine for treating acute mastitis.
The invention provides a preparation method of a traditional Chinese medicine for treating acute mastitis, which comprises the following steps:
s1: selecting raw materials: the composition comprises the following components in parts by weight:
10-14 parts of snakegourd fruit, 16-20 parts of red paeony root, 7-11 parts of weeping forsythia, 16-24 parts of dandelion, 8-12 parts of green tangerine peel, 4-8 parts of crucian carp, 4-8 parts of Japanese ampelopsis root, 6-10 parts of liquorice, 4-8 parts of saxifrage, 6-10 parts of Japanese cayratia herb, 6-10 parts of scutellaria baicalensis, 7-11 parts of great burdock achene, 8-12 parts of ricepaper pith, 4-8 parts of seaweed, 6-10 parts of fried cowherb seed and 4-8 parts of tangerine leaf;
s2: cleaning raw materials: putting the raw material of S1 into a cleaning pool for cleaning;
s3: and (3) drying treatment: placing the raw materials in S2 in a drying device for drying, wherein the internal temperature of the drying device is set to be 60-100 ℃, and the drying time is set to be 30-45min, so as to obtain dried raw materials for later use;
s4: mixing raw materials: mixing the dried raw materials in S3 in proportion, placing into a container, adding ethanol with 80-90% alcohol concentration 3-4 times of the total weight of the raw materials, keeping the temperature at 40-60 deg.C for 10-20min, alcoholizing at 60-100 deg.C for 2-3h, adding 3-5 times of distilled water, keeping the temperature at 60-75 deg.C for 50-70min, concentrating and recovering ethanol to obtain a mixed solution, filtering the mixed solution to obtain a filtrate, adding ethanol with 80-90% alcohol concentration 3-4 times of the total weight of the raw materials into the filtered traditional Chinese medicine residue, keeping the temperature at 40-60 deg.C for 10-20min, alcoholizing at 60-100 deg.C for 2-3h, adding 3-5 times of distilled water, keeping the temperature at 60-75 deg.C for 50-70min, concentrating and recovering ethanol to obtain a mixed solution, filtering the mixed solution to obtain filtrate, mixing the two filtrates, concentrating under reduced pressure to obtain soft extract with relative density of 1.11-1.13 at 60 deg.C, and drying to obtain dry extract;
s5: and (3) crushing treatment: grinding and crushing the dry paste obtained in the step S4 in a grinder for 10-20min to obtain primary powder, filtering and screening the primary powder by using a 16-mesh or 18-mesh screen to obtain superfine powder, and continuously grinding and crushing the powder remaining on the screen by using the grinder to obtain the superfine powder for later use;
s6: tabletting: adding 0.03-0.15 times of fructo-oligosaccharide and 0.1-0.2 times of coix seed powder into the ultrafine powder obtained in the step S5, stirring and mixing in a high-speed stirrer, adding microcrystalline cellulose which is 0.1-0.2 times of the mass of the ultrafine powder at a constant speed in the stirring and mixing process, granulating, drying, adding 0.01-0.03 times of magnesium stearate of the mass of the powder, granulating, and tabletting by using tabletting equipment to obtain the traditional Chinese medicine buccal tablet;
s7: packaging: and (5) sterilizing the traditional Chinese medicine buccal tablets obtained in the step (S6), and packaging to finally obtain the traditional Chinese medicine for treating acute mastitis.
Preferably, the S1 comprises the following components in parts by weight:
11-13 parts of snakegourd fruit, 17-19 parts of red paeony root, 8-10 parts of weeping forsythia, 18-22 parts of dandelion, 9-11 parts of green tangerine peel, 5-7 parts of crucian carp, 5-7 parts of Japanese ampelopsis root, 7-9 parts of liquorice, 5-7 parts of saxifrage, 7-9 parts of Japanese cayratia herb, 7-9 parts of scutellaria baicalensis, 8-10 parts of great burdock achene, 9-11 parts of ricepaper pith, 5-7 parts of seaweed, 7-9 parts of fried cowherb seed and 5-7 parts of tangerine leaf.
Preferably, the S1 comprises the following components in parts by weight:
12 parts of snakegourd fruit, 18 parts of red paeony root, 9 parts of weeping forsythia, 20 parts of dandelion, 10 parts of green tangerine peel, 6 parts of crucian carp grass, 6 parts of Japanese ampelopsis root, 8 parts of liquorice, 6 parts of saxifrage, 8 parts of cayratia japonica, 8 parts of baical skullcap root, 9 parts of great burdock achene, 10 parts of ricepaperplant pith, 6 parts of seaweed, 8 parts of fried cowherb seed and 6 parts of tangerine leaf.
Preferably, in the step S2, warm water at 30-40 ℃ is filled in the cleaning pool, and the raw materials are cleaned by the warm water at 30-40 ℃.
Preferably, in S3, the drying device is a dryer using microwave drying technology, and the optimum temperature inside the drying device is 75 ℃.
Preferably, in the S6, the rotating speed of the high-speed stirrer is 2000r/min, and the duration is 10-20 min.
Preferably, in S6, the tabletting equipment is a single-charging tabletting machine, and the tabletting equipment is covered and left standing for 10-20 min.
Preferably, in S7, the traditional Chinese medicine buccal tablet is sterilized by an ultraviolet irradiation lamp.
Preferably, in S4, the mixed solution is filtered by a filter to obtain a filtrate, and the filter is filtered by microfiltration.
Compared with the prior art, the invention has the beneficial effects that: dandelion has combining action of clearing liver; pericarpium citri reticulatae viride, bitter, pungent and warm, enters liver and gallbladder channels, has the effects of soothing liver, breaking qi, dispersing accumulation and resolving stagnation, and radix ampelopsis has the effects of cooling blood, stopping carbuncle, relaxing bowel, cooling blood and stopping bleeding, plays a main treatment role in the process of treating the stomach heat type acute mastitis, so the traditional Chinese medicine is a monarch drug, is bitter and cold in taste, enters lung, large and small intestines, spleen and gallbladder channels, can clear heat, discharge fire, clear heat, dry dampness, clear heat, prevent abortion, clear heat and reduce blood pressure, is bitter and dry in taste, can clear heat, is a heat-clearing and dampness-drying product, can clear away the lung heat, large and small intestines, spleen and gallbladder channels, and is particularly good for clearing lung fire, moving muscles, and exterior and clearing heat of large intestines; the fried cowherb seed is sweet, bitter and flat, enters liver and stomach channels, has the efficacies of promoting lactation, reducing swelling, activating blood circulation and stimulating menstrual flow, is characterized in that the cowherb seed cannot live in the stomach, cannot keep the mind, is good at promoting blood circulation, is mainly used as a special agent for promoting lactation, can reduce swelling and relieve pain, can also be used for treating carbuncle-abscess pyogenic infections, and is an adjuvant drug because the cowherb seed and uniflower swisscentaury root can enter the stomach channels and can reach the focus directly due to the efficacy of the drug; the liquorice is sweet and neutral, has the effects of tonifying spleen and lung, tonifying qi and restoring pulse, relieving spasm and pain, clearing heat and removing toxicity, and harmonizing drug properties, and the dandelion, the Japanese ampelopsis root, the cayratia japonica, the scutellaria baicalensis, the great burdock achene, the green tangerine orange peel, the fried cowherb seed and the liquorice are used in combination, so that the effects of clearing heat and removing toxicity, reducing swelling and resolving masses and treating carbuncle, relaxing bowel, soothing liver and breaking qi, regulating qi and tonifying spleen, promoting lactation and reducing swelling, and eliminating carbuncle and.
The preparation method is simple, the prepared traditional Chinese medicine has small toxic and side effects, is easy to absorb in the digestive tract, has short treatment course and high cure rate, and avoids rash, nausea, diarrhea, pseudomembranous enteritis and the like caused by adopting antibiotics; it can also relax middle energizer and lower qi to relieve chest stuffiness and dissipate nodulation, and glide down large intestine to moisten dryness and relax bowels, with the action of detumescence.
Detailed Description
The present invention will be further illustrated with reference to the following specific examples.
Example one
The embodiment provides a preparation method of a traditional Chinese medicine for treating acute mastitis, which comprises the following steps:
s1: selecting raw materials: the composition comprises the following components in parts by weight:
10 parts of snakegourd fruit, 16 parts of red paeony root, 7 parts of weeping forsythia, 16 parts of dandelion, 8 parts of green tangerine peel, 4 parts of crucian carp grass, 4 parts of Japanese ampelopsis root, 6 parts of liquorice, 4 parts of saxifrage, 6 parts of cayratia japonica, 6 parts of baical skullcap root, 7 parts of great burdock achene, 8 parts of ricepaperplant pith, 4 parts of seaweed, 6 parts of fried cowherb seed and 4 parts of tangerine leaf;
s2: cleaning raw materials: placing the raw material of S1 in a cleaning pool, wherein the cleaning pool is filled with warm water at 30 ℃, and cleaning the raw material by using the warm water at 30 ℃;
s3: and (3) drying treatment: placing the raw material in the S2 in a dryer for drying, wherein the dryer performs drying operation by using a microwave drying technology, the optimal temperature in the dryer is 75 ℃, and the drying time is set to be 30min, so as to obtain a dried raw material for later use;
s4: mixing raw materials: mixing the dried raw materials in S3 at a certain proportion, placing into a container, adding ethanol with 80% alcohol concentration 3 times of the total weight of the raw materials, keeping the temperature at 40 deg.C for 10min, alcoholizing at 60 deg.C for 2h, adding 3 times of distilled water, keeping the temperature at 60 deg.C for 50min, concentrating and recovering ethanol to obtain a mixed solution, filtering the mixed solution with a filter to obtain a filtrate, filtering with microporous filtration technology, adding ethanol with 80% alcohol concentration 3 times of the total weight of the filtered Chinese medicinal residue, keeping the temperature at 40 deg.C for 10min, alcoholizing at 60 deg.C for 2h, adding 3 times of distilled water, keeping the temperature at 60 deg.C for 50min, concentrating and recovering ethanol to obtain a mixed solution, filtering with a filter to obtain a filtrate, filtering with microporous filtration technology, mixing the filtrates, concentrating under reduced pressure, concentrating to obtain a soft extract with relative density of 1.11-1.13 at 60 deg.C, and drying, obtaining dry paste for later use;
s5: and (3) crushing treatment: grinding and crushing the dry paste obtained in the step S4 in a grinder for 10-20min to obtain primary powder, filtering and screening the primary powder by using a 16-mesh or 18-mesh screen to obtain superfine powder, and continuously grinding and crushing the powder remaining on the screen by using the grinder to obtain the superfine powder for later use;
s6: tabletting: adding 0.03 time of fructo-oligosaccharide and 0.1 time of coix seed powder into the ultrafine powder obtained in the step S5, stirring and mixing in a high-speed stirrer, wherein the rotating speed of the high-speed stirrer is 2000r/min, the duration is 10min, adding microcrystalline cellulose which is 0.1 time of the mass of the ultrafine powder at a constant speed in the stirring and mixing process, granulating, drying, adding 0.01 time of magnesium stearate of the mass of the powder, granulating, performing tabletting operation by using a tablet machine, and covering and standing the tablet machine for 10min to obtain the traditional Chinese medicine buccal tablets;
s7: packaging: and (5) sterilizing the traditional Chinese medicine buccal tablets obtained in the step (S6) by using an ultraviolet irradiation lamp, and packaging to finally obtain the traditional Chinese medicine for treating acute mastitis.
Example two
The embodiment provides a preparation method of a traditional Chinese medicine for treating acute mastitis, which comprises the following steps:
s1: selecting raw materials: the composition comprises the following components in parts by weight:
11 parts of snakegourd fruit, 17 parts of red paeony root, 8 parts of weeping forsythia, 18 parts of dandelion, 9 parts of green tangerine peel, 5 parts of crucian carp grass, 5 parts of Japanese ampelopsis root, 7 parts of liquorice, 5 parts of saxifrage, 7 parts of cayratia japonica, 7 parts of baical skullcap root, 8 parts of great burdock achene, 9 parts of ricepaperplant pith, 5 parts of seaweed, 7 parts of fried cowherb seed and 5 parts of tangerine leaf;
s2: cleaning raw materials: placing the raw material of S1 in a cleaning pool, wherein warm water at 35 ℃ is arranged in the cleaning pool, and cleaning the raw material by using the warm water at 35 ℃;
s3: and (3) drying treatment: placing the raw material in the S2 in a dryer for drying, wherein the dryer performs drying operation by using a microwave drying technology, the optimal temperature in the dryer is 75 ℃, and the drying time is set to be 35min, so as to obtain a dried raw material for later use;
s4: mixing raw materials: mixing the dried raw materials in S3 in proportion, placing into a container, adding ethanol with alcohol concentration of 85% according to 3.5 times of the total weight of the raw materials, keeping the temperature at 45 ℃ for 15min, alcoholizing at 80 ℃ for 2.5h, adding 4 times of distilled water, keeping the temperature at 70 ℃ for 60min, concentrating and recovering ethanol to obtain a mixed solution, filtering the mixed solution by using a filter to obtain a filtrate, filtering the filtered traditional Chinese medicine residue by using a microporous filtration technology, adding ethanol with alcohol concentration of 85% according to 3.5 times of the total weight of the raw materials into the filtered traditional Chinese medicine residue, keeping the temperature at 50 ℃ for 15min, alcoholizing at 80 ℃ for 2.5h, adding 4 times of distilled water, keeping the temperature at 70 ℃ for 60min, concentrating and recovering ethanol to obtain a mixed solution, filtering the mixed solution by using a filter to obtain a filtrate, filtering the filtered solution by using a microporous filtration technology, combining the two filtrates, concentrating under reduced pressure, concentrating to obtain a thick paste with relative density of 1.11-1.13 at 60 ℃ and drying, obtaining dry paste for later use;
s5: and (3) crushing treatment: grinding and crushing the dry paste obtained in the step S4 in a grinder for 15min to obtain primary powder, filtering and screening the primary powder by using a 16-mesh or 18-mesh screen to obtain superfine powder, and continuously grinding and crushing the powder remaining on the screen by using the grinder to finally obtain the superfine powder for later use;
s6: tabletting: adding 0.09 times of fructo-oligosaccharide and 0.15 times of coix seed powder into the ultrafine powder obtained in the step S5, stirring and mixing in a high-speed stirrer at a rotating speed of 2000r/min for 15min, adding microcrystalline cellulose which is 0.15 times of the mass of the ultrafine powder at a constant speed in the stirring and mixing process, granulating, drying, adding 0.02 times of magnesium stearate of the mass of the powder, granulating, tabletting by using a tablet press, and covering and standing the tablet press for 15min to obtain the traditional Chinese medicine buccal tablet;
s7: packaging: and (5) sterilizing the traditional Chinese medicine buccal tablets obtained in the step (S6) by using an ultraviolet irradiation lamp, and packaging to finally obtain the traditional Chinese medicine for treating acute mastitis.
EXAMPLE III
The embodiment provides a preparation method of a traditional Chinese medicine for treating acute mastitis, which comprises the following steps:
s1: selecting raw materials: the composition comprises the following components in parts by weight:
12 parts of snakegourd fruit, 18 parts of red paeony root, 9 parts of weeping forsythia, 20 parts of dandelion, 10 parts of green tangerine peel, 6 parts of crucian carp grass, 6 parts of Japanese ampelopsis root, 8 parts of liquorice, 6 parts of saxifrage, 8 parts of cayratia japonica, 8 parts of baical skullcap root, 9 parts of great burdock achene, 10 parts of ricepaperplant pith, 6 parts of seaweed, 8 parts of fried cowherb seed and 6 parts of tangerine leaf;
s2: cleaning raw materials: placing the raw material of S1 in a cleaning pool, wherein warm water at 35 ℃ is arranged in the cleaning pool, and cleaning the raw material by using the warm water at 35 ℃;
s3: and (3) drying treatment: placing the raw material in the S2 in a dryer for drying, wherein the dryer performs drying operation by using a microwave drying technology, the optimal temperature in the dryer is 75 ℃, and the drying time is set to be 35min, so as to obtain a dried raw material for later use;
s4: mixing raw materials: mixing the dried raw materials in S3 in proportion, placing into a container, adding ethanol with alcohol concentration of 85% according to 3.5 times of the total weight of the raw materials, keeping the temperature at 50 ℃ for 15min, alcoholizing at 80 ℃ for 2.5h, adding 4 times of distilled water, keeping the temperature at 70 ℃ for 60min, concentrating and recovering ethanol to obtain a mixed solution, filtering the mixed solution by using a filter to obtain a filtrate, filtering the filtered traditional Chinese medicine residue by using a microporous filtration technology, adding ethanol with alcohol concentration of 85% according to 3.5 times of the total weight of the raw materials, keeping the temperature at 50 ℃ for 15min, alcoholizing at 80 ℃ for 2.5h, adding 4 times of distilled water, keeping the temperature at 70 ℃ for 60min, concentrating and recovering ethanol to obtain a mixed solution, filtering the mixed solution by using a filter to obtain a filtrate, filtering by using a microporous filtration technology, combining the two filtrates, concentrating under reduced pressure, concentrating to obtain a thick paste with relative density of 1.11-1.13 at 60 ℃ and drying, obtaining dry paste for later use;
s5: and (3) crushing treatment: grinding and crushing the dry paste obtained in the step S4 in a grinder for 15min to obtain primary powder, filtering and screening the primary powder by using a 16-mesh or 18-mesh screen to obtain superfine powder, and continuously grinding and crushing the powder remaining on the screen by using the grinder to finally obtain the superfine powder for later use;
s6: tabletting: adding 0.09 times of fructo-oligosaccharide and 0.15 times of coix seed powder into the ultrafine powder obtained in the step S5, stirring and mixing in a high-speed stirrer at a rotating speed of 2000r/min for 15min, adding microcrystalline cellulose which is 0.15 times of the mass of the ultrafine powder at a constant speed in the stirring and mixing process, granulating, drying, adding 0.02 times of magnesium stearate of the mass of the powder, granulating, tabletting by using a tablet press, and covering and standing the tablet press for 15min to obtain the traditional Chinese medicine buccal tablet;
s7: packaging: and (5) sterilizing the traditional Chinese medicine buccal tablets obtained in the step (S6) by using an ultraviolet irradiation lamp, and packaging to finally obtain the traditional Chinese medicine for treating acute mastitis.
Example four
The embodiment provides a preparation method of a traditional Chinese medicine for treating acute mastitis, which comprises the following steps:
s1: selecting raw materials: the composition comprises the following components in parts by weight:
13 parts of snakegourd fruit, 19 parts of red paeony root, 10 parts of weeping forsythia, 22 parts of dandelion, 11 parts of green tangerine peel, 7 parts of crucian carp grass, 7 parts of Japanese ampelopsis root, 9 parts of liquorice, 7 parts of saxifrage, 9 parts of cayratia japonica, 9 parts of scutellaria baicalensis, 10 parts of great burdock achene, 11 parts of ricepaperplant pith, 7 parts of seaweed, 9 parts of fried cowherb seed and 7 parts of tangerine leaf;
s2: cleaning raw materials: placing the raw material of S1 in a cleaning pool, wherein warm water at 35 ℃ is arranged in the cleaning pool, and cleaning the raw material by using the warm water at 35 ℃;
s3: and (3) drying treatment: placing the raw material in the S2 in a dryer for drying, wherein the dryer performs drying operation by using a microwave drying technology, the optimal temperature in the dryer is 75 ℃, and the drying time is set to be 40min, so as to obtain a dried raw material for later use;
s4: mixing raw materials: mixing the dried raw materials in S3 in proportion, placing into a container, adding ethanol with alcohol concentration of 85% according to 3.5 times of the total weight of the raw materials, keeping the temperature at 50 ℃ for 15min, alcoholizing at 80 ℃ for 2.5h, adding 4 times of distilled water, keeping the temperature at 70 ℃ for 60min, concentrating and recovering ethanol to obtain a mixed solution, filtering the mixed solution by using a filter to obtain a filtrate, filtering the filtered traditional Chinese medicine residue by using a microporous filtration technology, adding ethanol with alcohol concentration of 85% according to 3.5 times of the total weight of the raw materials, keeping the temperature at 50 ℃ for 15min, alcoholizing at 80 ℃ for 2.5h, adding 4 times of distilled water, keeping the temperature at 70 ℃ for 60min, concentrating and recovering ethanol to obtain a mixed solution, filtering the mixed solution by using a filter to obtain a filtrate, filtering by using a microporous filtration technology, combining the two filtrates, concentrating under reduced pressure, concentrating to obtain a thick paste with relative density of 1.11-1.13 at 60 ℃ and drying, obtaining dry paste for later use;
s5: and (3) crushing treatment: grinding and crushing the dry paste obtained in the step S4 in a grinder for 15min to obtain primary powder, filtering and screening the primary powder by using a 16-mesh or 18-mesh screen to obtain superfine powder, and continuously grinding and crushing the powder remaining on the screen by using the grinder to finally obtain the superfine powder for later use;
s6: tabletting: adding 0.09 times of fructo-oligosaccharide and 0.15 times of coix seed powder into the ultrafine powder obtained in the step S5, stirring and mixing in a high-speed stirrer at a rotating speed of 2000r/min for 15min, adding microcrystalline cellulose which is 0.15 times of the mass of the ultrafine powder at a constant speed in the stirring and mixing process, granulating, drying, adding 0.02 times of magnesium stearate of the mass of the powder, granulating, tabletting by using a tablet press, and covering and standing the tablet press for 15min to obtain the traditional Chinese medicine buccal tablet;
s7: packaging: and (5) sterilizing the traditional Chinese medicine buccal tablets obtained in the step (S6) by using an ultraviolet irradiation lamp, and packaging to finally obtain the traditional Chinese medicine for treating acute mastitis.
EXAMPLE five
The embodiment provides a preparation method of a traditional Chinese medicine for treating acute mastitis, which comprises the following steps:
s1: selecting raw materials: the composition comprises the following components in parts by weight:
14 parts of snakegourd fruit, 20 parts of red paeony root, 11 parts of weeping forsythia, 24 parts of dandelion, 12 parts of green tangerine peel, 8 parts of crucian carp, 8 parts of Japanese ampelopsis root, 10 parts of liquorice, 8 parts of saxifrage, 10 parts of cayratia japonica, 10 parts of scutellaria baicalensis, 11 parts of great burdock achene, 12 parts of ricepaperplant pith, 8 parts of seaweed, 10 parts of fried cowherb seed and 8 parts of tangerine leaf;
s2: cleaning raw materials: placing the raw material of S1 in a cleaning pool, wherein the cleaning pool is filled with warm water of 40 ℃, and cleaning the raw material by using the warm water of 40 ℃;
s3: and (3) drying treatment: placing the raw material in the S2 in a dryer for drying, wherein the dryer performs drying operation by using a microwave drying technology, the optimal temperature in the dryer is 75 ℃, and the drying time is set to be 45min, so as to obtain a dried raw material for later use;
s4: mixing raw materials: mixing the dried raw materials in S3 in proportion, placing into a container, adding 90% ethanol according to 4 times of the total weight of the raw materials, keeping the temperature at 60 deg.C for 20min, alcoholizing at 100 deg.C for 3h, adding 5 times of distilled water, keeping the temperature at 75 deg.C for 70min, concentrating and recovering ethanol to obtain a mixed solution, filtering the mixed solution with a filter to obtain a filtrate, filtering with microporous filtration technology, adding 90% ethanol according to 4 times of the total weight of the raw materials into the filtered traditional Chinese medicine residue, keeping the temperature at 60 deg.C for 20min, alcoholizing at 100 deg.C for 3h, adding 5 times of distilled water, keeping the temperature at 75 deg.C for 70min, concentrating and recovering ethanol to obtain a mixed solution, filtering with a filter to obtain a filtrate, filtering with microporous filtration technology, mixing the filtrates, concentrating under reduced pressure to obtain a thick paste with a relative density of 1.11-1.13 at 60 deg.C, and drying, obtaining dry paste for later use;
s5: and (3) crushing treatment: grinding and crushing the dry paste obtained in the step S4 in a grinder for 20min to obtain primary powder, filtering and screening the primary powder by using a 16-mesh or 18-mesh screen to obtain superfine powder, and continuously grinding and crushing the powder remaining on the screen by using the grinder to finally obtain the superfine powder for later use;
s6: tabletting: adding 0.15 times of fructo-oligosaccharide and 0.2 times of coix seed powder into the ultrafine powder obtained in the step S5, stirring and mixing in a high-speed stirrer, wherein the rotating speed of the high-speed stirrer is 2000r/min, the duration is 20min, adding microcrystalline cellulose which is 0.2 times of the mass of the ultrafine powder at a constant speed in the stirring and mixing process, granulating, drying, adding 0.03 times of magnesium stearate of the mass of the powder, granulating, performing tabletting operation by using a tablet machine, and covering and standing the tablet machine for 20min to obtain the traditional Chinese medicine buccal tablet;
s7: packaging: and (5) sterilizing the traditional Chinese medicine buccal tablets obtained in the step (S6) by using an ultraviolet irradiation lamp, and packaging to finally obtain the traditional Chinese medicine for treating acute mastitis.
Compared with the traditional Chinese medicine for treating acute mastitis prepared in the first to fifth embodiments, the traditional Chinese medicine for treating acute mastitis is specifically as follows:
the table shows that the traditional Chinese medicine for treating acute mastitis prepared by the invention is obviously improved, and the third embodiment is the best embodiment.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (9)
1. A preparation method of a traditional Chinese medicine for treating acute mastitis is characterized by comprising the following steps:
s1: selecting raw materials: the composition comprises the following components in parts by weight:
10-14 parts of snakegourd fruit, 16-20 parts of red paeony root, 7-11 parts of weeping forsythia, 16-24 parts of dandelion, 8-12 parts of green tangerine peel, 4-8 parts of crucian carp, 4-8 parts of Japanese ampelopsis root, 6-10 parts of liquorice, 4-8 parts of saxifrage, 6-10 parts of Japanese cayratia herb, 6-10 parts of scutellaria baicalensis, 7-11 parts of great burdock achene, 8-12 parts of ricepaper pith, 4-8 parts of seaweed, 6-10 parts of fried cowherb seed and 4-8 parts of tangerine leaf;
s2: cleaning raw materials: putting the raw material of S1 into a cleaning pool for cleaning;
s3: and (3) drying treatment: placing the raw materials in S2 in a drying device for drying, wherein the internal temperature of the drying device is set to be 60-100 ℃, and the drying time is set to be 30-45min, so as to obtain dried raw materials for later use;
s4: mixing raw materials: mixing the dried raw materials in S3 in proportion, placing into a container, adding ethanol with 80-90% alcohol concentration 3-4 times of the total weight of the raw materials, keeping the temperature at 40-60 deg.C for 10-20min, alcoholizing at 60-100 deg.C for 2-3h, adding 3-5 times of distilled water, keeping the temperature at 60-75 deg.C for 50-70min, concentrating and recovering ethanol to obtain a mixed solution, filtering the mixed solution to obtain a filtrate, adding ethanol with 80-90% alcohol concentration 3-4 times of the total weight of the raw materials into the filtered traditional Chinese medicine residue, keeping the temperature at 40-60 deg.C for 10-20min, alcoholizing at 60-100 deg.C for 2-3h, adding 3-5 times of distilled water, keeping the temperature at 60-75 deg.C for 50-70min, concentrating and recovering ethanol to obtain a mixed solution, filtering the mixed solution to obtain filtrate, mixing the two filtrates, concentrating under reduced pressure to obtain soft extract with relative density of 1.11-1.13 at 60 deg.C, and drying to obtain dry extract;
s5: and (3) crushing treatment: grinding and crushing the dry paste obtained in the step S4 in a grinder for 10-20min to obtain primary powder, filtering and screening the primary powder by using a 16-mesh or 18-mesh screen to obtain superfine powder, and continuously grinding and crushing the powder remaining on the screen by using the grinder to obtain the superfine powder for later use;
s6: tabletting: adding 0.03-0.15 times of fructo-oligosaccharide and 0.1-0.2 times of coix seed powder into the ultrafine powder obtained in the step S5, stirring and mixing in a high-speed stirrer, adding microcrystalline cellulose which is 0.1-0.2 times of the mass of the ultrafine powder at a constant speed in the stirring and mixing process, granulating, drying, adding 0.01-0.03 times of magnesium stearate of the mass of the powder, granulating, and tabletting by using tabletting equipment to obtain the traditional Chinese medicine buccal tablet;
s7: packaging: and (5) sterilizing the traditional Chinese medicine buccal tablets obtained in the step (S6), and packaging to finally obtain the traditional Chinese medicine for treating acute mastitis.
2. The preparation method of the traditional Chinese medicine for treating acute mastitis according to claim 1, wherein the S1 comprises the following components in parts by weight:
11-13 parts of snakegourd fruit, 17-19 parts of red paeony root, 8-10 parts of weeping forsythia, 18-22 parts of dandelion, 9-11 parts of green tangerine peel, 5-7 parts of crucian carp, 5-7 parts of Japanese ampelopsis root, 7-9 parts of liquorice, 5-7 parts of saxifrage, 7-9 parts of Japanese cayratia herb, 7-9 parts of scutellaria baicalensis, 8-10 parts of great burdock achene, 9-11 parts of ricepaper pith, 5-7 parts of seaweed, 7-9 parts of fried cowherb seed and 5-7 parts of tangerine leaf.
3. The preparation method of the traditional Chinese medicine for treating acute mastitis according to claim 1, wherein the S1 comprises the following components in parts by weight:
12 parts of snakegourd fruit, 18 parts of red paeony root, 9 parts of weeping forsythia, 20 parts of dandelion, 10 parts of green tangerine peel, 6 parts of crucian carp grass, 6 parts of Japanese ampelopsis root, 8 parts of liquorice, 6 parts of saxifrage, 8 parts of cayratia japonica, 8 parts of baical skullcap root, 9 parts of great burdock achene, 10 parts of ricepaperplant pith, 6 parts of seaweed, 8 parts of fried cowherb seed and 6 parts of tangerine leaf.
4. The method for preparing a Chinese medicine for treating acute mastitis according to claim 1, wherein in S2, warm water of 30-40 ℃ is filled in a cleaning pool, and the raw materials are cleaned by the warm water of 30-40 ℃.
5. The method of claim 1, wherein in step S3, the drying device is a dryer using microwave drying technology, and the optimum temperature inside the drying device is 75 ℃.
6. The method for preparing a Chinese medicinal composition for treating acute mastitis according to claim 1, wherein in S6, the rotation speed of the high-speed stirrer is 2000r/min for 10-20 min.
7. The method for preparing a Chinese medicine for treating acute mastitis according to claim 1, wherein in S6, the tabletting equipment is a single tablet press, and the tabletting equipment is covered and left standing for 10-20 min.
8. The method for preparing a Chinese medicinal composition for treating acute mastitis according to claim 1, wherein in S7, the Chinese medicinal buccal tablet is sterilized by ultraviolet irradiation.
9. The method of claim 1, wherein in step S4, the mixture is filtered by a filter to obtain a filtrate, and the filter is filtered by microfiltration.
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