CN112137899B - 富勒烯c60乳液及其制备方法 - Google Patents
富勒烯c60乳液及其制备方法 Download PDFInfo
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- XMWRBQBLMFGWIX-UHFFFAOYSA-N C60 fullerene Chemical compound C12=C3C(C4=C56)=C7C8=C5C5=C9C%10=C6C6=C4C1=C1C4=C6C6=C%10C%10=C9C9=C%11C5=C8C5=C8C7=C3C3=C7C2=C1C1=C2C4=C6C4=C%10C6=C9C9=C%11C5=C5C8=C3C3=C7C1=C1C2=C4C6=C2C9=C5C3=C12 XMWRBQBLMFGWIX-UHFFFAOYSA-N 0.000 title claims abstract description 46
- 239000000839 emulsion Substances 0.000 title claims abstract description 30
- 238000002360 preparation method Methods 0.000 title abstract description 7
- 238000004945 emulsification Methods 0.000 title description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 75
- 229910003472 fullerene Inorganic materials 0.000 claims abstract description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 31
- 239000000284 extract Substances 0.000 claims abstract description 29
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims abstract description 25
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 14
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 14
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 14
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims abstract description 13
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- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims abstract description 13
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims abstract description 13
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- FRGAIZLZPOROJH-BKIJVIAGSA-N [(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[2-hydroxy-3-[2-hydroxy-3-(2-hydroxy-3-octadecanoyloxypropoxy)propoxy]propoxy]oxan-2-yl]methyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)COCC(O)COCC(O)CO[C@H]1O[C@H](COC(=O)CCCCCCCCCCCCCCCCC)[C@@H](O)[C@H](O)[C@H]1O FRGAIZLZPOROJH-BKIJVIAGSA-N 0.000 claims description 2
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- ROTFCACGLKOUGI-JYJNAYRXSA-N (2s)-2-[[(2s)-2-[[(2s)-2-(3-acetamidopropanoylamino)-3-(1h-imidazol-5-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1h-imidazol-5-yl)propanoic acid Chemical group C([C@H](NC(=O)CCNC(=O)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1NC=NC=1)C(O)=O)C1=CN=CN1 ROTFCACGLKOUGI-JYJNAYRXSA-N 0.000 claims 1
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- 208000003464 asthenopia Diseases 0.000 abstract description 6
- 239000013543 active substance Substances 0.000 abstract description 2
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- 241000196324 Embryophyta Species 0.000 description 1
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- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
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- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000009978 visual deterioration Effects 0.000 description 1
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Abstract
本发明公开了一种富勒烯c60乳液及其制备方法。该乳液由以下重量份的原料制备而成:水40‑60份、甘油3‑10份、丁二醇3‑10份、水解透明质酸钠1‑5份、维生素E油0.5‑5份、DEC 1‑5份、TEGOCARE450 1‑5份、Sspiplus400 0.5‑5份、海藻糖0.5‑5份、泛醇1‑5份、尿囊素0.5‑5份、氨基丁酸1‑5份、透明质酸钠0.1‑1份、功能提取物10‑20份、1,2‑戊二醇0.5‑5份,还包括富勒烯,所述富勒烯在乳液中的含量为0.3‑0.8mg/L。本发明的富勒烯c60乳液包括富勒烯、多种植物、微生物提取物等多种活性物质,涂抹在眼部能够显著改善视力、缓解视力疲劳,同时能够改善皮肤的水分含量。
Description
技术领域
本发明属于化妆品技术领域,具体涉及一种富勒烯c60乳液及其制备方法。
背景技术
视疲劳是一种眼科常见病,它所引起的眼干、眼涩、眼酸胀,视物模糊甚至视力下降直接影响着人的工作与生活。眼疲劳主要是由于人们平时全神贯注看电视、电脑或手机等电子产品屏幕时,眼睛眨眼次数减少,造成眼泪分泌相应减少,同时闪烁荧屏强烈刺激眼睛而引起的。眼疲劳还会引发和加重各种眼病。
富勒烯是一种新型的化妆品原料,目前还没有添加到眼部产品的相关报道。
发明内容
本发明尝试把富勒烯添加到眼部产品中,研究其对眼部的作用。
本发明的第一方面在于公开一种富勒烯c60乳液,由以下重量份的原料制备而成:
水40-60份、甘油3-10份、丁二醇3-10份、水解透明质酸钠1-5份、维生素E油0.5-5份、DEC 1-5份、TEGOCARE450 1-5份、Sspiplus400 0.5-5份、海藻糖0.5-5份、泛醇1-5份、尿囊素0.5-5份、氨基丁酸1-5份、透明质酸钠0.1-1份、功能提取物10-20份、1,2-戊二醇0.5-5份,还包括富勒烯,所述富勒烯在乳液中的含量为0.3-0.8mg/L,所述富勒烯为水溶性富勒烯。
在本发明的一些实施方式中,由以下重量份的原料制备而成:
水45-55份、甘油3-8份、丁二醇3-8份、水解透明质酸钠1-3份、维生素E油0.5-3份、DEC 1-5份、TEGOCARE450 1-3份、Sspiplus400 1-3份、海藻糖0.5-5份、泛醇1-3份、尿囊素1-3份、氨基丁酸1-5份、透明质酸钠0.2-0.8份、功能提取物12-18份、1,2-戊二醇1-3份,还包括富勒烯,所述富勒烯在乳液中的含量为0.5-0.7mg/L,所述富勒烯为水溶性富勒烯。
在本发明的一些实施方式中,所述富勒烯为富勒烯羟基化衍生物。
在本发明的一些实施方式中,所述功能提取物包括FUCOSORB、眼肽、水解燕麦蛋白、水解胶原、乳酸杆菌/人参根发酵产物滤液、巴西香可可籽提取物、二裂酵母发酵产物溶胞物、植物甾醇澳洲坚果油酸酯、精氨酸/赖氨酸多肽、积雪草提取物、光果甘草根提取物、仙桃仙人掌茎提取物。
在本发明的一些实施方式中,所述功能提取物中FUCOSORB、眼肽、水解燕麦蛋白、水解胶原、乳酸杆菌/人参根发酵产物滤液、巴西香可可籽提取物、二裂酵母发酵产物溶胞物、植物甾醇澳洲坚果油酸酯、精氨酸/赖氨酸多肽、积雪草提取物、光果甘草根提取物、仙桃仙人掌茎提取物的重量比为(5-15):(1-3):(0.5-1.5);(0.5-1.5):(0.1-1.0):(0.1-1.0):(0.1-0.5):(0.1-0.5):(0.1-1.0):(0.05-0.15):(0.1-0.5):(0.1-0.5)。
所述功能提取物中FUCOSORB、眼肽、水解燕麦蛋白、水解胶原、乳酸杆菌/人参根发酵产物滤液、巴西香可可籽提取物、二裂酵母发酵产物溶胞物、植物甾醇澳洲坚果油酸酯、精氨酸/赖氨酸多肽、积雪草提取物、光果甘草根提取物、仙桃仙人掌茎提取物的重量比为(8-12):(1-3):(0.5-1.5);(0.5-1.5):(0.3-0.8):(0.3-0.8):(0.2-0.4):(0.1-0.3):(0.3-0.5):(0.05-0.15):(0.2-0.4):(0.2-0.4)。
在本发明的一些实施方式中,以重量计,所述海藻糖和泛醇的含量分别为0.1-10%,优选为0.5-5%,进一步优选为1-4%。
在本发明的一些实施方式中,所述海藻糖和泛醇的重量比为(1-10):(10-1),优选为(1-5):(5-1),进一步优选为(1-3):(3-1)。
本发明第二方面在于公开第一方面所述的乳液的制备方法,包括以下步骤:
S1,水、甘油和丁二醇混合;
S2,加入水解透明质酸钠、维生素E油、DEC、TEGOCARE450、Sspiplus400,混合;
S3,加入海藻糖、泛醇、尿囊素、氨基丁酸、透明质酸钠、功能提取物,混合;
S4,加入1,2-戊二醇,混合;
S5,加入富勒烯,混合。
在本发明的一些实施方式中,在S1中,通过以下方法来确定水、甘油和丁二醇的重量百分比:
S11,水、甘油、丁二醇分别取3个重量百分比,1-2xa、xa、xa,1-2xb、xb、xb,1-2xc、xc、xc;
S12,混合,得到样品,在离心管中注入三分之二高度,用软木塞塞好,然后放入预先调节到38±1℃的恒湿培养箱中,保温1h,在2000rpm离心30min,取出观察;
S14,水、甘油、丁二醇的重量百分比取1-2x4、x4、x4;
S15,混合,得到样品,在离心管中注入三分之二高度,用软木塞塞好,然后放入预先调节到38±1℃的恒湿培养箱中,保温1h,在2000rpm离心30min,取出观察;
本发明的有益技术效果是:
本发明的富勒烯c60乳液包括富勒烯、多种植物、微生物提取物等多种活性物质,涂抹在眼部能够显著改善视力、缓解视力疲劳,同时能够改善皮肤的水分含量。
具体实施方式
以下通过特定的具体实例说明本发明的实施方式,本领域技术人员可由本说明书所揭露的内容轻易地了解本发明的其他优点与功效。本发明还可以通过另外不同的具体实施方式加以实施或应用,本说明书中的各项细节也可以基于不同观点与应用,在没有背离本发明的精神下进行各种修饰或改变。
下述实施例中所使用的实验方法如无特殊说明,均为常规方法。下述实施例中所用的材料、试剂等,如无特殊说明,均可从商业途径得到。所述富勒烯为富勒烯的羟基化衍生物(C60(OH)x•nH2O),溶于水,购自厦门福纳新材料科技有限公司。
实施例1
一种富勒烯c60乳液,其制备原料和配方如表1、表2所示。
其制备方法为,取带搅拌的容器,先加入A相各组分,混合搅拌,然后依次加入B、C、D、E各相的组分。混合过程中,可以视情况进行加热。
表1 富勒烯c60乳液的组分
实施例2
一种富勒烯c60乳液的制备方法
与实施例1的区别在于,在S1中,通过以下方法来确定水、甘油和丁二醇的重量百分比:
S11,水、甘油、丁二醇分别取3个重量百分比,1-2xa、xa、xa,1-2xb、xb、xb,1-2xc、xc、xc;
S12,混合,得到样品,在离心管中注入三分之二高度,用软木塞塞好,然后放入预先调节到38±1℃的恒湿培养箱中,保温1h,在2000rpm离心30min,取出观察;
S14,水、甘油、丁二醇的重量百分比取1-2x4、x4、x4;
S15,混合,得到样品,在离心管中注入三分之二高度,用软木塞塞好,然后放入预先调节到38±1℃的恒湿培养箱中,保温1h,在2000rpm离心30min,取出观察;
通过本实施例的方法,可以在尽量少实验的情况下,快速的确定符合粘度要求和离心考察的水、甘油和丁二醇的百分比含量。通过本实施例的方法得到的水、甘油和丁二醇的百分比含量混合得到的基质,以及用此基质制成的乳液产品稳定,离心实验中不分层。
实验例乳液的功能测试
实验对象:年满25岁,性别不限,中性皮肤,无皮肤过敏史,近期无眼部疾病。
实验1眼睛感受
实验组试剂使用实施例制备的乳液,对照组试剂使用重量含量0.5%的羟甲基纤维素钠水溶液。
实验对象清洗面部后,闭眼。实验人员把分别2ml实验组试剂和对照组试剂分别分两次轻涂于实验对象的眼睑,轻柔15s。调查记录实验对象的眼睛感受,主要考察指标为清晰度、亮度、肿胀、干涩、疲劳等主观感受。如果改善明显则计3分,有改善计1分,感觉不到差异则计0分。结果见表3。
表3 眼部感受
实验2皮肤水含量
实验组试剂为实施例制备的乳液,对比例试剂配方1-5分别与实施例1的配方1、4-7的区别在于,配方中没有富勒烯组分,用水补足至100%。制备方法类似实施例的制备方法,仅略去加E相组分的步骤。
实验对象清洗手臂后擦干。实验组试剂和对比例试剂分涂于一个实验对象的左右两个上臂,1g/cm2。15min后,清洗,擦干。
按如下方式分组:
第1组:实施例1配方1 对比例配方1;
第2组:实施例1配方4 对比例配方2;
第3组:实施例1配方5 对比例配方3;
第4组:实施例1配方6 对比例配方4;
第5组:实施例1配方7 对比例配方5。
15min后,清洗,擦干。分别在涂抹前和30min后用皮肤含水量测试仪测试水分含量(MMV法)。含水系数%=(后水分含量-前水分含量)/前水分含量×100,保湿系数=(实施例含水系数-对比例含水系数)/对比例含水系数×100。结果见表4。
表4乳液中的富勒烯保湿系数
以上对本发明优选的具体实施方式和实施例作了详细说明,但是本发明并不限于上述实施方式和实施例,在本领域技术人员所具备的知识范围内,还可以在不脱离本发明构思的前提下作出各种变化。
Claims (9)
1.一种用于眼部的富勒烯c60乳液,由以下重量份的原料制备而成:
水40-60份、甘油3-10份、丁二醇3-10份、水解透明质酸钠1-5份、维生素E油0.5-5份、DEC 1-5份、TEGOCARE450 1-5份、Sspiplus400 0.5-5份、海藻糖0.5-5份、泛醇1-5份、尿囊素0.5-5份、氨基丁酸1-5份、透明质酸钠0.1-1份、功能提取物10-20份、1,2-戊二醇0.5-5份,还包括富勒烯,所述富勒烯在乳液中的含量为0.3-0.8mg/L,所述富勒烯为水溶性富勒烯;
所述功能提取物包括FUCOSORB、眼肽、水解燕麦蛋白、水解胶原、乳酸杆菌/人参根发酵产物滤液、巴西香可可籽提取物、二裂酵母发酵产物溶胞物、植物甾醇澳洲坚果油酸酯、精氨酸/赖氨酸多肽、积雪草提取物、光果甘草根提取物、仙桃仙人掌茎提取物;
所述眼肽为乙酰基四肽-5;
以重量计,所述海藻糖和泛醇的含量分别为0.1-10%;
所述海藻糖和泛醇的重量比为(1-3):(3-1)。
2.根据权利要求1所述的乳液,其特征在于,由以下重量份的原料制备而成:
水45-55份、甘油3-8份、丁二醇3-8份、水解透明质酸钠1-3份、维生素E油0.5-3份、DEC1-5份、TEGOCARE450 1-3份、Sspiplus400 1-3份、海藻糖0.5-5份、泛醇1-3份、尿囊素1-3份、氨基丁酸1-5份、透明质酸钠0.2-0.8份、功能提取物12-18份、1,2-戊二醇1-3份,还包括富勒烯,所述富勒烯在乳液中的含量为0.5-0.7mg/L,所述富勒烯为水溶性富勒烯。
3.根据权利要求1或2所述的乳液,其特征在于,所述水溶性富勒烯为富勒烯羟基化衍生物。
4.根据权利要求1所述的乳液,其特征在于,所述功能提取物中FUCOSORB、眼肽、水解燕麦蛋白、水解胶原、乳酸杆菌/人参根发酵产物滤液、巴西香可可籽提取物、二裂酵母发酵产物溶胞物、植物甾醇澳洲坚果油酸酯、精氨酸/赖氨酸多肽、积雪草提取物、光果甘草根提取物、仙桃仙人掌茎提取物的重量比为(5-15):(1-3):(0.5-1.5);(0.5-1.5):(0.1-1.0):(0.1-1.0):(0.1-0.5):(0.1-0.5):(0.1-1.0):(0.05-0.15):(0.1-0.5):(0.1-0.5)。
5.根据权利要求1所述的乳液,其特征在于,所述功能提取物中FUCOSORB、眼肽、水解燕麦蛋白、水解胶原、乳酸杆菌/人参根发酵产物滤液、巴西香可可籽提取物、二裂酵母发酵产物溶胞物、植物甾醇澳洲坚果油酸酯、精氨酸/赖氨酸多肽、积雪草提取物、光果甘草根提取物、仙桃仙人掌茎提取物的重量比为(8-12):(1-3):(0.5-1.5);(0.5-1.5):(0.3-0.8):(0.3-0.8):(0.2-0.4):(0.1-0.3):(0.3-0.5):(0.05-0.15):(0.2-0.4):(0.2-0.4)。
6.根据权利要求1或2所述的乳液,其特征在于,以重量计,所述海藻糖和泛醇的含量分别为0.5-5%。
7.根据权利要求1或2所述的乳液,其特征在于,以重量计,所述海藻糖和泛醇的含量分别为1-4%。
8.一种根据权利要求1-7任一所述的用于眼部的富勒烯c60乳液的制备方法,包括以下步骤:
S1,水、甘油和丁二醇混合;
S2,加入水解透明质酸钠、维生素E油、DEC、TEGOCARE450、Sspiplus400,混合;
S3,加入海藻糖、泛醇、尿囊素、氨基丁酸、透明质酸钠、功能提取物,混合;
S4,加入1,2-戊二醇,混合;
S5,加入富勒烯,混合。
9.根据权利要求8所述的制备方法,其特征在于,在S1中,通过以下方法来确定水、甘油和丁二醇的重量百分比:
S11,水、甘油、丁二醇分别取3个重量百分比,1-2xa、xa、xa,1-2xb、xb、xb,1-2xc、xc、xc;
S12,混合,得到样品,在离心管中注入三分之二高度,用软木塞塞好,然后放入预先调节到38±1℃的恒湿培养箱中,保温1h,在2000rpm离心30min,取出观察;
S14,水、甘油、丁二醇的重量百分比取1-2x4、x4、x4;
S15,混合,得到样品,在离心管中注入三分之二高度,用软木塞塞好,然后放入预先调节到38±1℃的恒湿培养箱中,保温1h,在2000rpm离心30min,取出观察;
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