CN112121151B - 一种用于女性生殖道预防、保健以及治疗的天然草本药物组方及提取制备方法 - Google Patents
一种用于女性生殖道预防、保健以及治疗的天然草本药物组方及提取制备方法 Download PDFInfo
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Abstract
本发明提供一种用于女性生殖道预防、保健以及治疗的天然草本药物组方及提取制备方法，所述天然草本药物组方：包括以下重量份原料：卡琪花蒂玛24～50份、蚕丝肽12～30份、抗菌肽10～30份、藏红花11～25份、蛇床子8～12份、当归10～28份、丹参8～15份、葡萄籽油10～28份、安痛藤13～25份、板栗花10～20份、人表皮生长因子11～25份，各原料药科学配比，相互配伍具有协同增效的作用，有效改善妇科炎症、痛经等常见症，去腐生肌，激活细胞，提高阴道黏膜细胞的再生能力达到缩阴的效果，促进女性生殖道恢复紧致状态，不破坏内环境酸碱平衡。
Description
技术领域
本发明涉及中药领域，特别涉及一种用于女性生殖道预防、保健以及治疗的天然草本药物组方及提取制备方法。
背景技术
女性生殖系统的疾病即为妇科疾病，包括外阴疾病、阴道疾病、子宫疾病、输卵管疾病、卵巢疾病等。妇科疾病是女性常见病、多发病。但由于许多人对妇科疾病缺乏应有的认识，缺乏对身体的保健，加之各种不良生活习惯等，使生理健康每况愈下，导致一些女性疾病缠身，且久治不愈，给正常的生活、工作带来极大的不便。市面上很多私护产品大部分都是化学组成药物，作为清洁消炎，使用不当导致私处pH值的破坏，酸碱不平衡，使私处免疫力越来越低，从而引发各种妇科问题。
发明内容
鉴于此，本发明提出一种用于女性生殖道预防、保健以及治疗的天然草本药物组方及提取制备方法，解决上述问题。
本发明的技术方案是这样实现的：一种用于女性生殖道预防、保健以及治疗的天然草本药物组方：包括以下重量份原料：卡琪花蒂玛24～50份、蚕丝肽12～30份、抗菌肽10～30份、藏红花11～25份、蛇床子8～12份、当归10～28份、丹参8～15份、葡萄籽油10～28份、安痛藤13～25份、板栗花10～20份、人表皮生长因子11～25份。
优选地，一种用于女性生殖道预防、保健以及治疗的天然草本药物组方，包括以下重量份原料：卡琪花蒂玛40份、蚕丝肽22份、抗菌肽20份、藏红花20份、蛇床子10份、当归15份、丹参12份、葡萄籽油18份、安痛藤20份、板栗花15份、人表皮生长因子20份。
进一步的，一种用于女性生殖道预防、保健以及治疗的天然草本药物组方的制备方法，包括以下步骤：
S1、按上述重量份将卡琪花蒂玛、藏红花、蛇床子、当归、丹参、安痛藤、板栗花经80～95％乙醇蒸馏，收集挥发油和蒸馏液，取蒸馏后的药渣加水经煎煮，过滤后收集滤液；
S2、将上述S1的蒸馏液和滤液混合，浓缩，得到浸膏Ⅰ；
S3、将蚕丝肽、抗菌肽、葡萄籽油、人表皮生长因子经水浴加热回流，收集提取液浓缩得到浸膏Ⅱ；
S4、将上述S1收集得到的挥发油和浸膏Ⅰ、浸膏Ⅱ经搅拌混合，得到天然草本药物组方制剂。
优选地，所述乙醇的添加量为S1混合物料体积的2～5倍。
优选地，所述蒸馏温度为60～120℃，蒸馏时间为1～8min。
优选地，所述煎煮的温度为40～80℃，煎煮时间为2～4h。
优选地，所述水浴加热回流的温度为70～100℃。
优选地，所述搅拌速率为100～300rpm，搅拌时间1～5min。
与现有技术相比，本发明的有益效果是：
本发明运用中药的君臣佐使合理配置，本方中，卡琪花蒂玛、藏红花为君药，卡琪花蒂玛调整经期、改善经痛，藏红花活血化瘀，散郁开结；蛇床子、当归互为臣药，蛇床子治宫冷，寒湿带下，湿痹腰痛，当归补血活血，调经止痛，润肠通便；丹参、安痛藤、板栗花共为佐使药，丹参祛瘀止痛，活血通经，清心除烦，安痛藤祛风止痛，舒筋活络，拔脓消肿，板栗花清热燥湿，止血，散结；结合蚕丝肽、抗菌肽、人表皮生长因子，各原料药科学配比，相互配伍具有协同增效的作用，有效改善妇科炎症、痛经等常见症，去腐生肌，激活细胞，提高阴道黏膜细胞的再生能力达到缩阴的效果，促进女性生殖道恢复紧致状态，不破坏内环境酸碱平衡，无副作用。
本发明提供用于女性生殖道预防、保健以及治疗的天然草本药物组方的制备方法，利用乙醇溶液将有效成分共同提取，控制蒸馏温度和时间，在特定的条件下能改变细胞壁的通透性，有效提取活性成分，成分稳定。
具体实施方式
为了更好理解本发明技术内容，下面提供具体实施例，对本发明做进一步的说明。
本发明实施例所用的实验方法如无特殊说明，均为常规方法。
本发明实施例所用的材料、试剂等，如无特殊说明，均可从商业途径得到。
藏红花：为鸢尾科植物番红花花柱的上部及柱头，【性味】甘，平；【归经】入心、肝经；【功能主治】活血化瘀，散郁开结。治忧思郁结，胸膈痞闷，吐血，伤寒发狂，惊怖恍惚，妇女经闭，产后瘀血腹痛，跌扑肿痛。
蛇床子：本品为伞形科植物蛇床的干燥成熟果实，【性味】辛、苦，温；有小毒；【归经】归肾经；【功能主治】温肾壮阳，燥湿，祛风，杀虫。用于阳痿，宫冷，寒湿带下，湿痹腰痛；外治外阴湿疹，妇人阴痒；滴虫性阴道炎。
当归：本品为伞形科植物当归的干燥根；【性味】甘、辛，温。【归经】归肝、心、脾经。【功能主治】补血活血，调经止痛，润肠通便。用于血虚萎黄，眩晕心悸，月经不调，经闭痛经，虚寒腹痛，肠燥便秘，风湿痹痛，跌扑损伤，痈疽疮疡。酒当归活血通经。用于经闭痛经，风湿痹痛，跌扑损伤。
丹参：本品为唇形科植物丹参的干燥根及根茎；【性味】苦，微寒。【归经】归心、肝经。【功能主治】祛瘀止痛，活血通经，清心除烦。用于月经不调，经闭痛经，症瘕积聚，胸腹刺痛，热痹疼痛，疮疡肿痛，心烦不眠；肝脾肿大，心绞痛。
安痛藤：【性味】淡、微涩，平。【归经】归肺、胃经。【功能与主治】祛风止痛，舒筋活络，拔脓消肿。用于跌打损伤，扭伤，风湿关节疼痛，骨折，痈疮肿毒。
板栗花：【性味】微苦、涩，平。【归经】归大肠、肝经。【功能与主治】清热燥湿，止血，散结。用于泄泻，痢疾，带下，便血，瘰疬，瘿瘤。
实施例1
一种用于女性生殖道预防、保健以及治疗的天然草本药物：包括以下重量份原料：卡琪花蒂玛24份、蚕丝肽12份、抗菌肽10份、藏红花11份、蛇床子8份、当归10份、丹参8份、葡萄籽油10份、安痛藤13份、板栗花10份、人表皮生长因子11份。
实施例2
一种用于女性生殖道预防、保健以及治疗的天然草本药物：包括以下重量份原料：卡琪花蒂玛50份、蚕丝肽30份、抗菌肽30份、藏红花25份、蛇床子12份、当归28份、丹参15份、葡萄籽油28份、安痛藤25份、板栗花20份、人表皮生长因子25份。
实施例3
一种用于女性生殖道预防、保健以及治疗的天然草本药物：卡琪花蒂玛40份、蚕丝肽22份、抗菌肽20份、藏红花20份、蛇床子10份、当归15份、丹参12份、葡萄籽油18份、安痛藤20份、板栗花15份、人表皮生长因子20份。
上述实施例1～3使用以下提取制备方法：
S1、按上述重量份将卡琪花蒂玛、藏红花、蛇床子、当归、丹参、安痛藤、板栗花经体积的4倍的90％乙醇蒸馏，蒸馏温度为90℃，蒸馏时间为5min，收集挥发油和蒸馏液，取蒸馏后的药渣加水经煎煮，煎煮的温度为60℃，煎煮时间为3h，过滤后收集滤液；
S2、将上述S1的蒸馏液和滤液混合，浓缩，得到浸膏Ⅰ；
S3、将蚕丝肽、抗菌肽、葡萄籽油、人表皮生长因子经90℃的水浴加热回流，收集提取液浓缩得到浸膏Ⅱ；
S4、将上述S1收集得到的挥发油和浸膏Ⅰ、浸膏Ⅱ经搅拌混合，搅拌速率为200rpm，搅拌时间3min，得到天然草本药物组方制剂。
实施例4
本实施例和实施例3的区别在于，天然草本药物使用以下制备方法：
S1、按上述重量份将卡琪花蒂玛、藏红花、蛇床子、当归、丹参、安痛藤、板栗花经体积的2倍的80％乙醇蒸馏，蒸馏温度为60℃，蒸馏时间为1min，收集挥发油和蒸馏液，取蒸馏后的药渣加水经煎煮，煎煮的温度为40℃，煎煮时间为2h，过滤后收集滤液；
S2、将上述S1的蒸馏液和滤液混合，浓缩，得到浸膏Ⅰ；
S3、将蚕丝肽、抗菌肽、葡萄籽油、人表皮生长因子经70℃的水浴加热回流，收集提取液浓缩得到浸膏Ⅱ；
S4、将上述S1收集得到的挥发油和浸膏Ⅰ、浸膏Ⅱ经搅拌混合，搅拌速率为100rpm，搅拌时间1min，得到天然草本药物组方制剂。
实施例5
本实施例和实施例3的区别在于，天然草本药物使用以下制备方法：
S1、按上述重量份将卡琪花蒂玛、藏红花、蛇床子、当归、丹参、安痛藤、板栗花经体积的5倍的95％乙醇蒸馏，蒸馏温度为120℃，蒸馏时间为8min，收集挥发油和蒸馏液，取蒸馏后的药渣加水经煎煮，煎煮的温度为80℃，煎煮时间为4h，过滤后收集滤液；
S2、将上述S1的蒸馏液和滤液混合，浓缩，得到浸膏Ⅰ；
S3、将蚕丝肽、抗菌肽、葡萄籽油、人表皮生长因子经100℃的水浴加热回流，收集提取液浓缩得到浸膏Ⅱ；
S4、将上述S1收集得到的挥发油和浸膏Ⅰ、浸膏Ⅱ经搅拌混合，搅拌速率为300rpm，搅拌时间5min，得到天然草本药物组方制剂。
一、抑菌实验
(1)试验菌株：大肠杆菌、白色念球菌、金黄色葡萄球菌，各培养9代。
(2)载体：滤纸片、无菌刻度吸管、无菌平皿、无菌试管、恒温培养箱。
(3)方法依据GB15979-200《一次性使用卫生用品卫生标准》附录C4、《消毒技术规范》进行检验。
(4)结果：在试验温度20℃±2℃的条件下，实施例1～5所制得的天然草本药物对大肠杆菌、白色念球菌、金黄色葡萄球菌的抑菌效果。
试验结果如下：
由上述表明，本发明的天然草本药物，各组分相互配合，协同增效，具有良好的抑菌效果，大肠杆菌的抑菌率为95％以上，白色念球菌的抑菌率为94％以上，金黄色葡萄球菌的抑菌率为94％以上。
二、临床试验
(1)试验人员：收集诊断为BV的患者250例，随机分为5个组，年龄22～56岁已有性生活的女性，平均年龄30.2岁。排除：严重肝、肾、心脏、造血系统及神经系统疾病患者，合并其他感染者，有药物过敏史者，就诊前一月内使用治疗细菌性阴道病的同类药物(口服制剂和栓剂)；妊娠期和哺乳期妇女患者。经妇科检查及实验室分泌物镜检发现上述致病微生物同时阳性。
(2)试验方法：按照实施例1～5分别使用本发明的草本药物制剂，每晚睡觉前将本发明的草本药物制剂推入阴道深处，连续10日一疗程，共进行3个疗程。
(3)BV临床诊断标准：下列4条中有3条阳性即可临床诊断为细菌性阴道病。①匀质、稀薄、灰白色阴道分泌物，可有臭味或鱼腥味；②阴道pH>4.5；
③胺臭味试验阳性：将阴道分泌物拭子放在10％氢氧化钾溶液试管内或将阴道分泌物与10％氢氧化钾溶液放在载玻片上混合，可引出鱼腥味；④线索细胞阳性：取阴道分泌物放在载玻片上，加一滴生理盐水混合，高倍镜下寻找线索细胞。线索细胞>20％为阳性。
(4)疗效判定标准
显效：BV诊断标准中4项均为阴性，临床症状消失；
有效：BV诊断标准中4项标准中1-2项阳性；
无效：BV诊断标准中4项标准中有3项或3项以上阳性。
(5)效果试验结果
经上述临床试验结果显示，本发明的草本药物针对BV疗效有明显的改善作用，还能提高阴道黏膜细胞的再生能力达到缩阴的效果，其中实施例3为最佳配方和最佳的工艺提取制备方法，显效率达到96.0％，总有效率100％。
以上所述仅为本发明的较佳实施例而已，并不用以限制本发明，凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。
Claims (6)
1.一种用于治疗女性细菌性阴道病的天然草本药物组方，其特征在于：包括以下重量份原料：卡琪花蒂玛24~50份、蚕丝肽12~30份、抗菌肽10~30份、藏红花11~25份、蛇床子8~12份、当归10~28份、丹参8~15份、葡萄籽油10~28份、安痛藤13~25份、板栗花10~20份、人表皮生长因子11~25 份；
所述天然草本药物组方的制备方法包括以下步骤：
S1、按上述重量份将卡琪花蒂玛、藏红花、蛇床子、当归、丹参、安痛藤、板栗花经80~95%乙醇蒸馏，收集挥发油和蒸馏液，取蒸馏后的药渣加水经煎煮，过滤后收集滤液；
S2、将上述S1 的蒸馏液和滤液混合，浓缩，得到浸膏Ⅰ；
S3、将蚕丝肽、抗菌肽、葡萄籽油、人表皮生长因子经水浴加热回流，收集提取液浓缩得到浸膏Ⅱ；
S4、将上述S1 收集得到的挥发油和浸膏Ⅰ、浸膏Ⅱ经搅拌混合，得到天然草本药物组方制剂；
所述蒸馏温度为60~120℃，蒸馏时间为1~8min。
2.如权利要求 1所述的一种用于治疗女性细菌性阴道病的天然草本药物组方，其特征在于：包括以下重量份原料：卡琪花蒂玛 40份、蚕丝肽 22份、抗菌肽 20份、藏红花 20份、蛇床子 10 份、当归 15份、丹参 12份、葡萄籽油 18 份、安痛藤 20 份、板栗花 15 份、人表皮生长因子 20 份。
3.如权利要求1所述的一种用于治疗女性细菌性阴道病的天然草本药物组方，其特征在于：所述乙醇的添加量为S1混合物料体积的2~5倍。
4.如权利要求1所述的一种用于治疗女性细菌性阴道病的天然草本药物组方，其特征在于：所述煎煮的温度为40~80℃，煎煮时间为2~4h。
5.如权利要求1所述的一种用于治疗女性细菌性阴道病的天然草本药物组方，其特征在于：所述水浴加热回流的温度为70~100℃。
6.如权利要求1所述的一种用于治疗女性细菌性阴道病的天然草本药物组方，其特征在于：所述搅拌速率为100~300rpm，搅拌时间1~5min。
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