CN112121143A - Pharmaceutical composition for treating chronic osteomyelitis - Google Patents

Pharmaceutical composition for treating chronic osteomyelitis Download PDF

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CN112121143A
CN112121143A CN202011232951.3A CN202011232951A CN112121143A CN 112121143 A CN112121143 A CN 112121143A CN 202011232951 A CN202011232951 A CN 202011232951A CN 112121143 A CN112121143 A CN 112121143A
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radix
chronic osteomyelitis
pharmaceutical composition
rhizoma
treating chronic
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江劲明
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Abstract

The invention discloses a pharmaceutical composition for treating chronic osteomyelitis, which comprises the following raw materials in parts by weight: 15-25 g of ginger ephedra, 15-25 g of radix cynanchi bungei, 10-20 g of monkshood, 5-15 g of eucommia bark, 7-10 g of sappan wood, 7-10 g of codonopsis pilosula, 12-15 g of bighead atractylodes rhizome, 18-20 g of cimicifuga foetida, 15-17 g of astragalus mongholicus, 2-4 g of platycodon grandiflorum, 4-6 g of rhizoma drynariae, 7-9 g of liquorice, 10-20 g of radix puerariae, 20-30 g of angelica sinensis and 5-15 g of honeysuckle. The invention has good treatment effect, quick response, safety, reliability and proper compatibility of medicines without toxic or side effect, and the processing is based on the medicine property, so as to achieve the effect of treating both symptoms and root causes, promote blood circulation and regulate qi, remove blood stasis and dissipate toxin, have excellent curative effect on chronic osteomyelitis, obviously improve the immunity of human body, and can be widely applied to clinical treatment of chronic osteomyelitis.

Description

Pharmaceutical composition for treating chronic osteomyelitis
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a pharmaceutical composition for treating chronic osteomyelitis.
Background
Chronic osteomyelitis is an infection and destruction of bones caused by aerobic or anaerobic bacteria, mycobacteria, and fungi. Chronic osteomyelitis occurs well in vertebrae; the foot of a diabetic patient or the site of penetrating bone damage due to trauma or surgery. The most common part of children is long bones with good blood supply; such as the metaphysis of the tibia or femur.
Infection is caused by blood borne microorganisms (chronic osteomyelitis of blood origin); spread from infected tissues, including infection of replacement joints, contaminating fractures, and bone surgery. The most common pathogen is gram-positive bacteria. Chronic osteomyelitis caused by gram-negative bacteria can be seen in drug addicts, sickle cell disease patients and severe diabetic or trauma patients. Lesions in patients infected with fungi and mycobacteria are often localized to the bone and cause painless chronic infections. Risk factors include wasting diseases, radiation therapy, malignancies, diabetes, hemodialysis and intravenous medication. In children, any process that causes bacteremia may induce chronic osteomyelitis.
Chronic osteomyelitis refers to an inflammatory disease caused by pyogenic bacterial infection of bone marrow, cortical bone and periosteum, mostly caused by blood sources, and mostly caused by trauma or surgical infection, and mostly caused by suppurative bacteria toxin of furuncle and carbuncle or other focuses entering blood to reach bone tissues. The extremities are most vulnerable to invasion, especially the hip joint. Repeated attacks are common in clinic, and the physical and mental health and labor capacity are seriously affected. Acute chronic osteomyelitis is characterized by high fever and local pain, and chronic osteomyelitis can result in rupture, pus discharge, dead bone or cavity formation. Serious patients are often life-threatening, sometimes the emergency approach of amputation has to be taken, resulting in the life-long disability of the patient.
The current method for treating chronic osteomyelitis is mainly surgical treatment, and the most common treatment method at present comprises thorough focus clearing, open cancellous bone grafting and repeated flushing. However, surgical treatment is risky and costly. The traditional Chinese medicine is from nature, has no toxic or side effect and takes effect quickly. Therefore, the development of a medicine for helping a patient to get rid of the pain caused by the chronic osteomyelitis is urgently needed.
Disclosure of Invention
The invention aims to solve the defects in the prior art and provides a pharmaceutical composition for treating chronic osteomyelitis.
A pharmaceutical composition for treating chronic osteomyelitis comprises the following raw materials in parts by weight: 15-25 g of ginger ephedra, 15-25 g of radix cynanchi bungei, 10-20 g of monkshood, 5-15 g of eucommia bark, 7-10 g of sappan wood, 7-10 g of codonopsis pilosula, 12-15 g of bighead atractylodes rhizome, 18-20 g of cimicifuga foetida, 15-17 g of astragalus mongholicus, 2-4 g of platycodon grandiflorum, 4-6 g of rhizoma drynariae, 7-9 g of liquorice, 10-20 g of radix puerariae, 20-30 g of angelica sinensis and 5-15 g of honeysuckle.
Further, the feed comprises the following raw materials in parts by weight: 15 g of ginger ephedra, 15 g of radix cynanchi, 10 g of monkshood, 5 g of eucommia bark, 7 g of sappan wood, 7 g of codonopsis pilosula, 12 g of bighead atractylodes rhizome, 18 g of rhizoma cimicifugae, 15 g of astragalus, 2 g of platycodon grandiflorum, 4 g of rhizoma drynariae, 7 g of liquorice, 10 g of radix puerariae, 20 g of angelica and 5 g of honeysuckle.
Further, the feed comprises the following raw materials in parts by weight: 20 g of ginger ephedra, 20 g of radix cynanchi, 15 g of monkshood, 10 g of eucommia bark, 8 g of sappan wood, 8 g of codonopsis pilosula, 14 g of bighead atractylodes rhizome, 19 g of rhizoma cimicifugae, 16 g of astragalus, 3 g of platycodon grandiflorum, 5 g of rhizoma drynariae, 8 g of liquorice, 15 g of radix puerariae, 25 g of angelica and 10 g of honeysuckle.
Further, the feed comprises the following raw materials in parts by weight: 25 g of ginger ephedra, 25 g of radix cynanchi, 20 g of monkshood, 15 g of eucommia bark, 10 g of sappan wood, 10 g of codonopsis pilosula, 15 g of bighead atractylodes rhizome, 20 g of rhizoma cimicifugae, 17 g of astragalus, 4 g of platycodon grandiflorum, 6 g of rhizoma drynariae, 9 g of liquorice, 20 g of radix puerariae, 30 g of angelica and 15 g of honeysuckle.
A method for preparing a pharmaceutical composition for treating chronic osteomyelitis, comprising the steps of:
s1, cleaning radix Malloti Apeltae, radix Aconiti lateralis Preparata, Atractylodis rhizoma, cimicifugae rhizoma, rhizoma Drynariae, Glycyrrhrizae radix, radix Angelicae sinensis and flos Lonicerae, drying, grinding, and sieving;
s2, eucommia ulmoides, sappan wood, codonopsis pilosula, astragalus membranaceus, platycodon grandiflorum and radix puerariae are placed into a container, 15 times of distilled water is added into the container to be soaked for 5 hours, then the mixture is heated and boiled for 6 hours, and extraction is carried out; adding 7 times of distilled water for the second time, heating and boiling for 5 hours, and extracting; adding 4 times of distilled water for heating and boiling for 2 hours for the third time, and extracting; mixing the three extractive solutions, and filtering to obtain filtrate;
s3, pouring the powder prepared in the step S1 into a frying pan, adding 3 g of salt, stir-frying for 30 minutes, then taking out the mixed powder, adding a proper amount of warm water, and stirring the mixed powder;
and S4, putting the viscous semi-fluid stirred in the step S3 into a medicine tank, and adding the filtrate obtained in the step S2 into the medicine tank to stir for 10 minutes.
Further, the mesh number of the sieve is 800.
Further, the stir-frying temperature in S3 was maintained at 65 ℃.
The invention has good treatment effect, quick response, safety, reliability and proper compatibility of medicines without toxic or side effect, and the processing is based on the medicine property to treat both symptoms and root causes, promote blood circulation and regulate qi, remove blood stasis and dissipate toxin; the Chinese medicinal composition has the advantages of solving the problem of difficulty brought by the osteomyelitis to people by adopting pure Chinese medicinal herbs as raw materials, along with simple formula preparation, low cost, no side effect on patients, good absorption effect, obvious curative effect, safety, reliability, no toxic or side effect or clinical adverse reaction, excellent curative effect on chronic osteomyelitis, obvious improvement on human immunity and wide application in clinical treatment of the chronic osteomyelitis.
The pharmacology of the invention is as follows:
ginger and ephedra: dispelling wind cold, warming stomach with pungent and warm natured drugs, dispersing lung qi, relieving cough, astringing lung, and consolidating exterior;
white back blade root: clearing heat, eliminating dampness, astringing, and promoting blood circulation;
monkshood: reviving yang and rescuing from collapse, tonifying fire and supporting yang, dispelling cold and relieving pain;
eucommia bark has the effects of tonifying liver and kidney, and treating soreness and pain of waist and spine, weakness of feet and knees, dribbling urination, pruritus due to damp invasion of yin, hypertension and miscarriage prevention;
sappan wood: traumatic injury, fracture, muscle injury, stasis, swelling and pain, amenorrhea, dysmenorrhea, puerperal blood stasis, thoracico-abdominal pain, carbuncle, cellulitis, swelling and pain;
codonopsis pilosula: radically curing short breath, palpitation, dry mouth, spontaneous perspiration, tiredness, hypodynamia, weakness of spleen and stomach, lung deficiency, dry cough, postpartum blood deficiency, anorexia, loose stool, hematochezia, metrorrhagia and metrostaxis and rectocele;
white atractylodes rhizome: can be used for treating spleen deficiency, anorexia, abdominal distention, diarrhea, phlegm retention, vertigo, edema, and spontaneous perspiration;
cimicifugae foetidae: relieving exterior syndrome, promoting eruption, clearing away heat and toxic materials, and invigorating yang;
astragalus root: can be used for treating spontaneous perspiration due to exterior deficiency, internal injury due to qi deficiency, listlessness, general fatigue, diarrhea due to spleen deficiency, asthenia, hyperhidrosis, rectocele due to qi deficiency, prolapse of son and organ, edema, and superficial infection;
balloon flower: disperse lung qi, relieve sore throat, dispel phlegm, and expel pus. Can be used for treating cough with excessive phlegm, chest distress, pharyngalgia, hoarseness, lung carbuncle, suppuration, and pyocutaneous disease with pus formation;
rhizoma drynariae: dissipating blood stasis, relieving pain, reuniting bone, treating toothache, lumbago, and chronic diarrhea;
licorice root: can be used for treating heart-qi deficiency, cardiopalmus, intermittent pulse, spleen and stomach qi deficiency, listlessness, debilitation;
kudzu root: relieving muscles and fever, promoting eruption, promoting fluid production to quench thirst, invigorating yang and relieving diarrhea;
chinese angelica: enriching the blood; promoting blood circulation; regulating menstruation and relieving pain; moistening dryness and smoothing intestine. The main symptoms are blood deficiency; menoxenia; amenorrhea; dysmenorrhea; the accumulation of symptoms; (ii) metrorrhagia and metrostaxis; abdominal pain due to deficiency-cold; flaccidity and paralysis; numbness of the skin; intestinal dryness and difficult defecation; severe dysentery with diarrhea; carbuncle, cellulitis, sore and ulcer; traumatic injury; bombyx Batryticatus: wind-extinguishing and spasm-stopping, wind-dispelling and pain-relieving, phlegm-resolving and mass-resolving;
honeysuckle flower: it can be used for treating fever due to affection of exogenous wind-heat or epidemic febrile disease, heatstroke, toxic heat, dysentery, carbuncle, furuncle, pharyngitis, and various infectious diseases.
Detailed Description
The present invention will be further illustrated with reference to the following specific examples.
The invention provides a pharmaceutical composition for treating chronic osteomyelitis
Example 1
15 g of ginger ephedra, 15 g of radix cynanchi, 10 g of monkshood, 5 g of eucommia bark, 7 g of sappan wood, 7 g of codonopsis pilosula, 12 g of bighead atractylodes rhizome, 18 g of rhizoma cimicifugae, 15 g of astragalus, 2 g of platycodon grandiflorum, 4 g of rhizoma drynariae, 7 g of liquorice, 10 g of radix puerariae, 20 g of angelica and 5 g of honeysuckle.
S1, cleaning radix Malloti Apeltae, radix Aconiti lateralis Preparata, Atractylodis rhizoma, cimicifugae rhizoma, rhizoma Drynariae, Glycyrrhrizae radix, radix Angelicae sinensis and flos Lonicerae, drying, grinding, and sieving;
s2, eucommia ulmoides, sappan wood, codonopsis pilosula, astragalus membranaceus, platycodon grandiflorum and radix puerariae are placed into a container, 15 times of distilled water is added into the container to be soaked for 5 hours, then the mixture is heated and boiled for 6 hours, and extraction is carried out; adding 7 times of distilled water for the second time, heating and boiling for 5 hours, and extracting; adding 4 times of distilled water for heating and boiling for 2 hours for the third time, and extracting; mixing the three extractive solutions, and filtering to obtain filtrate;
s3, pouring the powder prepared in the step S1 into a frying pan, adding 3 g of salt, stir-frying for 30 minutes, then taking out the mixed powder, adding a proper amount of warm water, and stirring the mixed powder;
and S4, putting the viscous semi-fluid stirred in the step S3 into a medicine tank, and adding the filtrate obtained in the step S2 into the medicine tank to stir for 10 minutes.
Example 2:
20 g of ginger ephedra, 20 g of radix cynanchi, 15 g of monkshood, 10 g of eucommia bark, 8 g of sappan wood, 8 g of codonopsis pilosula, 14 g of bighead atractylodes rhizome, 19 g of rhizoma cimicifugae, 16 g of astragalus, 3 g of platycodon grandiflorum, 5 g of rhizoma drynariae, 8 g of liquorice, 15 g of radix puerariae, 25 g of angelica and 10 g of honeysuckle.
S1, cleaning radix Malloti Apeltae, radix Aconiti lateralis Preparata, Atractylodis rhizoma, cimicifugae rhizoma, rhizoma Drynariae, Glycyrrhrizae radix, radix Angelicae sinensis and flos Lonicerae, drying, grinding, and sieving;
s2, eucommia ulmoides, sappan wood, codonopsis pilosula, astragalus membranaceus, platycodon grandiflorum and radix puerariae are placed into a container, 15 times of distilled water is added into the container to be soaked for 5 hours, then the mixture is heated and boiled for 6 hours, and extraction is carried out; adding 7 times of distilled water for the second time, heating and boiling for 5 hours, and extracting; adding 4 times of distilled water for heating and boiling for 2 hours for the third time, and extracting; mixing the three extractive solutions, and filtering to obtain filtrate;
s3, pouring the powder prepared in the step S1 into a frying pan, adding 3 g of salt, stir-frying for 30 minutes, then taking out the mixed powder, adding a proper amount of warm water, and stirring the mixed powder;
and S4, putting the viscous semi-fluid stirred in the step S3 into a medicine tank, and adding the filtrate obtained in the step S2 into the medicine tank to stir for 10 minutes.
Example 3
25 g of ginger ephedra, 25 g of radix cynanchi, 20 g of monkshood, 15 g of eucommia bark, 10 g of sappan wood, 10 g of codonopsis pilosula, 15 g of bighead atractylodes rhizome, 20 g of rhizoma cimicifugae, 17 g of astragalus, 4 g of platycodon grandiflorum, 6 g of rhizoma drynariae, 9 g of liquorice, 20 g of radix puerariae, 30 g of angelica and 15 g of honeysuckle.
S1, cleaning radix Malloti Apeltae, radix Aconiti lateralis Preparata, Atractylodis rhizoma, cimicifugae rhizoma, rhizoma Drynariae, Glycyrrhrizae radix, radix Angelicae sinensis and flos Lonicerae, drying, grinding, and sieving;
s2, eucommia ulmoides, sappan wood, codonopsis pilosula, astragalus membranaceus, platycodon grandiflorum and radix puerariae are placed into a container, 15 times of distilled water is added into the container to be soaked for 5 hours, then the mixture is heated and boiled for 6 hours, and extraction is carried out; adding 7 times of distilled water for the second time, heating and boiling for 5 hours, and extracting; adding 4 times of distilled water for heating and boiling for 2 hours for the third time, and extracting; mixing the three extractive solutions, and filtering to obtain filtrate;
s3, pouring the powder prepared in the step S1 into a frying pan, adding 3 g of salt, stir-frying for 30 minutes, then taking out the mixed powder, adding a proper amount of warm water, and stirring the mixed powder;
and S4, putting the viscous semi-fluid stirred in the step S3 into a medicine tank, and adding the filtrate obtained in the step S2 into the medicine tank to stir for 10 minutes.
400 patients are selected from the above examples 1, 2 and 3, and the 400 patients are randomly divided into 4 groups, and the medicine is taken 3 times a day, 2 tablets each time, and taken with warm water within half an hour after meals, and 7 days is a course of treatment.
Examples Example 1 Example 2 Example 3 Control group
The effect is very good 98 99 97 80
General effects 1 1 1 12
The effect is poor 1 0 2 8
Immunity enhancement 95 98 97 2
From the above table it can be seen that: the invention has obvious curative effect, safety and reliability, has excellent curative effect on chronic osteomyelitis, obviously improves the immunity of human bodies, and can be widely applied to clinical treatment of chronic osteomyelitis.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.

Claims (7)

1. A pharmaceutical composition for treating chronic osteomyelitis is characterized by comprising the following raw materials in parts by weight: 15-25 g of ginger ephedra, 15-25 g of radix cynanchi bungei, 10-20 g of monkshood, 5-15 g of eucommia bark, 7-10 g of sappan wood, 7-10 g of codonopsis pilosula, 12-15 g of bighead atractylodes rhizome, 18-20 g of cimicifuga foetida, 15-17 g of astragalus mongholicus, 2-4 g of platycodon grandiflorum, 4-6 g of rhizoma drynariae, 7-9 g of liquorice, 10-20 g of radix puerariae, 20-30 g of angelica sinensis and 5-15 g of honeysuckle.
2. The pharmaceutical composition for treating chronic osteomyelitis as claimed in claim 1, which comprises the following raw materials in parts by weight: 15 g of ginger ephedra, 15 g of radix cynanchi, 10 g of monkshood, 5 g of eucommia bark, 7 g of sappan wood, 7 g of codonopsis pilosula, 12 g of bighead atractylodes rhizome, 18 g of rhizoma cimicifugae, 15 g of astragalus, 2 g of platycodon grandiflorum, 4 g of rhizoma drynariae, 7 g of liquorice, 10 g of radix puerariae, 20 g of angelica and 5 g of honeysuckle.
3. The pharmaceutical composition for treating chronic osteomyelitis as claimed in claim 1, which comprises the following raw materials in parts by weight: 20 g of ginger ephedra, 20 g of radix cynanchi, 15 g of monkshood, 10 g of eucommia bark, 8 g of sappan wood, 8 g of codonopsis pilosula, 14 g of bighead atractylodes rhizome, 19 g of rhizoma cimicifugae, 16 g of astragalus, 3 g of platycodon grandiflorum, 5 g of rhizoma drynariae, 8 g of liquorice, 15 g of radix puerariae, 25 g of angelica and 10 g of honeysuckle.
4. The pharmaceutical composition for treating chronic osteomyelitis as claimed in claim 1, which comprises the following raw materials in parts by weight: 25 g of ginger ephedra, 25 g of radix cynanchi, 20 g of monkshood, 15 g of eucommia bark, 10 g of sappan wood, 10 g of codonopsis pilosula, 15 g of bighead atractylodes rhizome, 20 g of rhizoma cimicifugae, 17 g of astragalus, 4 g of platycodon grandiflorum, 6 g of rhizoma drynariae, 9 g of liquorice, 20 g of radix puerariae, 30 g of angelica and 15 g of honeysuckle.
5. A method for preparing a pharmaceutical composition for treating chronic osteomyelitis, comprising the steps of:
s1, cleaning radix Malloti Apeltae, radix Aconiti lateralis Preparata, Atractylodis rhizoma, cimicifugae rhizoma, rhizoma Drynariae, Glycyrrhrizae radix, radix Angelicae sinensis and flos Lonicerae, drying, grinding, and sieving;
s2, eucommia ulmoides, sappan wood, codonopsis pilosula, astragalus membranaceus, platycodon grandiflorum and radix puerariae are placed into a container, 15 times of distilled water is added into the container to be soaked for 5 hours, then the mixture is heated and boiled for 6 hours, and extraction is carried out; adding 7 times of distilled water for the second time, heating and boiling for 5 hours, and extracting; adding 4 times of distilled water for heating and boiling for 2 hours for the third time, and extracting; mixing the three extractive solutions, and filtering to obtain filtrate;
s3, pouring the powder prepared in the step S1 into a frying pan, adding 3 g of salt, stir-frying for 30 minutes, then taking out the mixed powder, adding a proper amount of warm water, and stirring the mixed powder;
and S4, putting the viscous semi-fluid stirred in the step S3 into a medicine tank, and adding the filtrate obtained in the step S2 into the medicine tank to stir for 10 minutes.
6. The method for preparing a pharmaceutical composition for the treatment of chronic osteomyelitis as claimed in claim 1, wherein said sieve has a mesh size of 800.
7. The method for preparing a pharmaceutical composition for treating chronic osteomyelitis as claimed in claim 1, wherein the temperature of stir-frying in S3 is maintained at 65 ℃.
CN202011232951.3A 2020-11-06 2020-11-06 Pharmaceutical composition for treating chronic osteomyelitis Pending CN112121143A (en)

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Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
李轶等: "双花芷辛甘汤加减治疗放射性颌骨骨髓炎疗效观察", 《新中医》 *

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Application publication date: 20201225