CN112121037A - A disinfectant product composition - Google Patents
A disinfectant product composition Download PDFInfo
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- CN112121037A CN112121037A CN202011031617.1A CN202011031617A CN112121037A CN 112121037 A CN112121037 A CN 112121037A CN 202011031617 A CN202011031617 A CN 202011031617A CN 112121037 A CN112121037 A CN 112121037A
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- composition
- oral
- chlorhexidine acetate
- peg
- menthol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a disinfection product composition, and belongs to the field of oral care. The disinfection product composition disclosed by the invention comprises eucalyptol, chlorhexidine acetate, citric acid, sodium citrate, PEG-60 hydrogenated castor oil, menthol, sucralose and auxiliary raw materials with anti-inflammatory effects, so that the disinfection product composition prepared by the invention can effectively inhibit bacteria in the oral cavity, keep the oral cavity fresh and dry. The disinfectant composition can be processed into oral disinfectant products and the like, and has no toxicity or side effect.
Description
Technical Field
The invention belongs to the field of oral care, and relates to a disinfection product composition.
Background
The oral cavity is a complete ecosystem, and provides a beneficial environment for the growth and reproduction of various microorganisms in the oral cavity. The oral microorganisms comprise bacteria, viruses and the like with complex species, protect the health of the oral cavity of a host and are closely related to diseases. However, disturbed oral microbial distribution can lead to a series of oral problems. Such as dental plaque, is one of the most important factors causing dental diseases such as periodontal disease and dental caries. The growth, reproduction and acid production of bacteria in the plaque can lead to demineralization of tooth enamel, resulting in the formation of dental caries. Dental plaque has strong adhesion. The key to plaque control is the frequent control of harmful oral bacteria, keeping the applied bacteriostatic agents effective for a long time.
Oral cleaning care solutions include mouthwashes, which are primarily intended to clean the oral cavity and mask oral malodour. However, oral cleaning solutions also have problems, such as being too irritating and causing some damage to the oral epithelial cells. In addition, if the bacteriostatic active ingredients lose proper storage conditions, the bacteriostatic ability is reduced. In response to these problems, the present invention provides a disinfecting product.
Disclosure of Invention
It is an object of the present invention to provide a disinfecting composition.
The object of the present invention is to provide a method for the preparation of a disinfecting composition.
It is an object of the present invention to provide a disinfecting product composition including a disinfecting composition.
It is an object of the present invention to provide an oral hygiene product composition, including a disinfecting composition.
The technical scheme adopted by the invention is as follows:
the invention provides an oral cavity disinfection composition, which comprises the following components: antibacterial agents, cooling agents, fragrances, surfactants, sweeteners, skin conditioners, fragrances, pigments, alcohol and water; the antibacterial agent is at least one of eucalyptol and chlorhexidine acetate.
According to an embodiment of the invention, the skin conditioning agent is at least one of chlorhexidine acetate, citric acid, sodium citrate.
According to an embodiment of the invention, the cooling agent is menthol and/or mint.
According to an embodiment of the invention, the fragrance is a perfume.
According to an embodiment of the invention, the surfactant is PEG-60 hydrogenated castor oil and/or poloxamer 407.
According to an embodiment of the invention, the composition comprises the following components in parts by weight: 0.05-0.3 part of eucalyptol, 0.05-0.3 part of menthol, 0.1-0.5 part of essence, 0.2-0.7 part of PEG-60 hydrogenated castor oil, 0.1-0.3 part of sucralose, 0.05-0.3 part of chlorhexidine acetate, 0.016-0.516 part of citric acid, 0.048-0.088 part of sodium citrate, 0.002-0.222 part of pigment and 7-13 parts of alcohol.
The present invention provides a process for the preparation of a composition as defined in any preceding claim, comprising the steps of:
(1) weighing essence, eucalyptol and PEG-60 hydrogenated castor oil into a container, and mixing;
(2) weighing menthol, and dissolving with alcohol;
(3) adding sucralose, chlorhexidine acetate and water, stirring, adjusting pH, and adjusting color with pigment.
According to the examples of the present invention, citric acid and sodium citrate were used to adjust the pH to 6-7.
The present invention provides an oral hygiene product comprising an oral hygiene composition as defined in any of the preceding claims.
The invention has the beneficial effects that:
the oral cavity disinfection product disclosed by the invention comprises eucalyptol, chlorhexidine acetate, citric acid, sodium citrate, PEG-60 hydrogenated castor oil, menthol, sucralose and auxiliary raw materials with anti-inflammatory effects, so that the disinfection composition prepared by the invention can effectively inhibit bacteria in the oral cavity, keep the oral cavity fresh and dry.
Detailed Description
The present invention will be described in further detail with reference to specific examples, but the present invention is not limited thereto.
The starting materials, reagents or apparatus used in the following examples are conventionally commercially available or can be obtained by a method known in the art, unless otherwise specified. Wherein the chlorhexidine acetate is purchased from Henan Wangli biological technology limited, and the product number is 56-95-1; menthol was purchased from Zhengzhou Wangbu chemical products Co., Ltd, with a cargo number of 16179; PEG-60 hydrogenated castor oil is available from Shandong Youso chemical technology Co., Ltd under the trade name S12715145.
Examples 1-4 formulations of various compositions are given in Table 1
TABLE 1
Comparative examples 1-4 formulations of different compositions are given in Table 2
TABLE 2
The preparation method of the composition comprises the following steps:
(1) weighing eucalyptol, essence and PEG-60 hydrogenated castor oil into a container, and mixing;
(2) then weighing menthol and alcohol, stirring and dissolving;
(3) weighing chlorhexidine acetate and water, stirring to dissolve, adjusting pH to 6 with citric acid and sodium citrate, and color-adjusting with pigment.
The next effect test is carried out on the composition.
The test was carried out using an ATP fluorescence detector, Byes-420, from Banyi accurate measuring instrument (Shanghai) Co., Ltd. to test the bactericidal activity of each of the examples and comparative examples.
The test method comprises the following steps:
1. firstly, one end with a cotton head is infected with bacteria, and the number of the bacteria at the moment is tested and recorded as the initial number of the bacteria V1;
2. smearing a sample to be tested on a cotton head which is infected with bacteria, and testing the bacteria number V2 after shaking for 1 minute;
3. (V1-V2)/V1 ═ f (sterilization rate)
The test results are shown in the following table:
TABLE 3 Sterilization Rate test results for oral Disinfection products
The properties of the different compositions are shown in table 3. As can be seen from the table, the compositions provided in the examples of the present invention have disinfecting efficacy. Therefore, the composition can be processed into disinfection products, such as oral cavity disinfection products, mouthwash and disinfection toothpaste, and the composition has an obvious effect by matching active ingredients, so that the anti-inflammation and bacteriostasis of a target area are realized.
While the embodiments of the present invention have been described in detail, the present invention is not limited to the embodiments, and various changes can be made without departing from the spirit of the present invention within the knowledge of those skilled in the art. Furthermore, the embodiments of the present invention and the features of the embodiments may be combined with each other without conflict.
Claims (9)
1. An oral disinfecting composition comprising the following components: antibacterial agents, cooling agents, fragrances, surfactants, sweeteners, skin conditioners, fragrances, pigments, alcohol and water; the antibacterial agent is at least one of eucalyptol and chlorhexidine acetate.
2. The composition of claim 1, wherein the skin conditioning agent is at least one of chlorhexidine acetate, citric acid, and sodium citrate.
3. The composition according to claim 1, characterized in that the cooling agent is menthol and/or mint.
4. The composition of claim 1, wherein the fragrance is a perfume.
5. The composition of claim 1, wherein the surfactant is PEG-60 hydrogenated castor oil and/or poloxamer 407.
6. The composition according to any one of claims 1 to 5, wherein the composition comprises the following components in parts by weight: 0.05-0.3 part of eucalyptol, 0.05-0.3 part of menthol, 0.1-0.5 part of essence, 0.2-0.7 part of PEG-60 hydrogenated castor oil, 0.1-0.3 part of sucralose, 0.05-0.3 part of chlorhexidine acetate, 0.016-0.516 part of citric acid, 0.048-0.088 part of sodium citrate, 0.002-0.222 part of pigment and 7-13 parts of alcohol.
7. A process for the preparation of a composition according to any one of claims 1 to 6, comprising the steps of:
(1) weighing essence, eucalyptol and PEG-60 hydrogenated castor oil into a container, and mixing;
(2) weighing menthol, and dissolving with alcohol;
(3) adding sucralose, chlorhexidine acetate and water, stirring, adjusting pH, and adjusting color with pigment.
8. The method of claim 7, wherein the pH is adjusted to 6-7 using citric acid and sodium citrate.
9. An oral hygiene product comprising an oral hygiene composition according to any of claims 1 to 6.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011031617.1A CN112121037A (en) | 2020-09-27 | 2020-09-27 | A disinfectant product composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011031617.1A CN112121037A (en) | 2020-09-27 | 2020-09-27 | A disinfectant product composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112121037A true CN112121037A (en) | 2020-12-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011031617.1A Pending CN112121037A (en) | 2020-09-27 | 2020-09-27 | A disinfectant product composition |
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| Country | Link |
|---|---|
| CN (1) | CN112121037A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050191247A1 (en) * | 2004-03-01 | 2005-09-01 | David Drake | Chlorhexidine compositions |
| CN102335102A (en) * | 2010-07-28 | 2012-02-01 | 重庆健能医药开发有限公司 | Chlorhexidine gluconate gargle |
| CN103893026A (en) * | 2014-03-31 | 2014-07-02 | 陈光健 | Mouth wash for oral hygiene and health care |
| CN104997667A (en) * | 2015-07-01 | 2015-10-28 | 南阳市汇博生物技术有限公司 | Multifunctional antibacterial mouthwash and preparation method thereof |
-
2020
- 2020-09-27 CN CN202011031617.1A patent/CN112121037A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050191247A1 (en) * | 2004-03-01 | 2005-09-01 | David Drake | Chlorhexidine compositions |
| CN102335102A (en) * | 2010-07-28 | 2012-02-01 | 重庆健能医药开发有限公司 | Chlorhexidine gluconate gargle |
| CN103893026A (en) * | 2014-03-31 | 2014-07-02 | 陈光健 | Mouth wash for oral hygiene and health care |
| CN104997667A (en) * | 2015-07-01 | 2015-10-28 | 南阳市汇博生物技术有限公司 | Multifunctional antibacterial mouthwash and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 谢明勇等: "《日用化学品实用生产技术与配方》", 30 June 2002, 江西科学技术出版社 * |
| 陈孝治等: "《新编实用药物手册 第3版》", 31 October 2003, 湖南科学技术出版社 * |
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| PB01 | Publication | ||
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20201225 |
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| RJ01 | Rejection of invention patent application after publication |