CN112105269A - 含有多磷酸盐的片剂 - Google Patents
含有多磷酸盐的片剂 Download PDFInfo
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- CN112105269A CN112105269A CN201980031782.6A CN201980031782A CN112105269A CN 112105269 A CN112105269 A CN 112105269A CN 201980031782 A CN201980031782 A CN 201980031782A CN 112105269 A CN112105269 A CN 112105269A
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- 229920000388 Polyphosphate Polymers 0.000 title claims abstract description 31
- 239000001205 polyphosphate Substances 0.000 title claims abstract description 31
- 235000011176 polyphosphates Nutrition 0.000 title claims abstract description 31
- 239000002245 particle Substances 0.000 claims description 11
- 235000019832 sodium triphosphate Nutrition 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 7
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 claims description 6
- 230000015572 biosynthetic process Effects 0.000 claims description 5
- 229920005862 polyol Polymers 0.000 claims description 5
- 150000003077 polyols Chemical class 0.000 claims description 5
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 3
- 238000007907 direct compression Methods 0.000 claims description 3
- 239000011591 potassium Substances 0.000 claims description 3
- 229910052700 potassium Inorganic materials 0.000 claims description 3
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims description 3
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 claims description 3
- 235000019982 sodium hexametaphosphate Nutrition 0.000 claims description 3
- 229940048086 sodium pyrophosphate Drugs 0.000 claims description 3
- UGTZMIPZNRIWHX-UHFFFAOYSA-K sodium trimetaphosphate Chemical compound [Na+].[Na+].[Na+].[O-]P1(=O)OP([O-])(=O)OP([O-])(=O)O1 UGTZMIPZNRIWHX-UHFFFAOYSA-K 0.000 claims description 3
- 239000000600 sorbitol Substances 0.000 claims description 3
- 235000010356 sorbitol Nutrition 0.000 claims description 3
- 235000019818 tetrasodium diphosphate Nutrition 0.000 claims description 3
- UNXRWKVEANCORM-UHFFFAOYSA-I triphosphate(5-) Chemical compound [O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O UNXRWKVEANCORM-UHFFFAOYSA-I 0.000 claims description 3
- 235000009508 confectionery Nutrition 0.000 abstract description 4
- 235000019629 palatability Nutrition 0.000 abstract description 4
- 230000002087 whitening effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 description 6
- 238000012360 testing method Methods 0.000 description 5
- 239000000203 mixture Substances 0.000 description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- 206010013911 Dysgeusia Diseases 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 239000003082 abrasive agent Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 230000001055 chewing effect Effects 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 210000004283 incisor Anatomy 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000000905 isomalt Substances 0.000 description 1
- 235000010439 isomalt Nutrition 0.000 description 1
- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- -1 peroxide compounds Chemical class 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000036344 tooth staining Effects 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/362—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/42—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds characterised by the carbohydrates used, e.g. polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/60—Particulates further characterized by their structure or composition
- A61K2800/65—Characterized by the composition of the particulate/core
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/92—Oral administration
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- Food Science & Technology (AREA)
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- Emergency Medicine (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Confectionery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Bakery Products And Manufacturing Methods Therefor (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
公开了一种含有微粉化多磷酸盐的糖果产品。本发明的产品具有牙齿增白特性和良好的适口性。
Description
本发明涉及含有至少一种微粉化多磷酸盐的糖果产品，特别是片剂。
现有技术
US6685916中描述了用于去除牙齿色斑的含有多磷酸盐的组合物，该专利建议将下列多磷酸盐中的一种与其它物质、包括过氧化物化合物和阴离子表面活性剂一起使用：三聚磷酸钠、三聚磷酸钾、焦磷酸钠、三偏磷酸钠和六偏磷酸钠。
US6685916通过提出基于选择特定剂量的所述多磷酸盐的溶液来解决多磷酸盐典型的令人不愉快的余味问题。
还已知多磷酸盐会在含有它们的产品中引起明显的残留粗糙度。
例如，US3054656，其特别涉及用于洗涤剂工业的纯三聚磷酸钠的生产，明确地提及了粗糙问题，其可以通过在非常高的温度下在特定湿度条件下加工三聚磷酸钠来消除。
EP1227789描述了包含多磷酸盐的糖果产品，其中没有说明多磷酸盐的粒度，这与其它成分、特别是硅酸盐不同，后者用作研磨剂，粒度为0.1-30微米。多磷酸盐仅用于牙膏中，而不用于片剂中。
US 2003/003219描述了使用粒度为200-400微米的多磷酸盐来减少牙齿色斑。
US 2003/008062描述了用于口腔卫生的可咀嚼组合物，特别是口香糖，其含有各种成分，包括嵌入粗糙、松脆基质中的微粉化多磷酸盐，所述基质包含能够提供所需粗糙、松脆质地的大颗粒。
发明详述
现已发现，通过使用微粉化形式的多磷酸盐可以消除含有多磷酸盐的片剂的极端粗糙度。
减少多磷酸盐的尺寸显著改善了粗糙感，否则在使用时会强烈地感觉到粗糙感而令人不快。
还发现，通过直接压制微粉化多磷酸盐和至少一种多元醇而不进行造粒步骤，可以有利地解决片剂粗糙的问题。
因此，本发明涉及包含一种或多种微粉化形式的多磷酸盐和一种或多种多元醇的片剂。通过直接压制获得的本发明的片剂具有光滑、不粗糙或松脆的质地，并且可在几分钟内溶解于口腔中而不用咀嚼。
根据本发明，至少90％重量的用于制备糖果产品、特别是片剂的多磷酸盐具有小于150μm的粒度。
本发明提出的解决方案不同于US6685916提出的解决方案，其始终在处理余味这一不同的技术问题，并且不同于US3054656提出的解决方案，其虽然解决了相同的技术问题，但是通过的是完全不同的方法。
优选使用微粉化的聚磷酸盐，其中超过90％重量的颗粒具有小于150μm的尺寸，优选超过90％重量的颗粒具有小于106μm的尺寸，更优选超过80％重量的颗粒具有小于53μm的尺寸。
微粉化的多磷酸盐可以在市场上获得，或者可以通过将商业多磷酸盐进行常规的微粉化方法直到达到上述规格来获得。
本发明的片剂不含糖，但可以含有任何多元醇，优选山梨糖醇、木糖醇和异麦芽酮糖醇，可以是单独的或混合的。优选山梨醇，重量百分比为80-98％。它还可以包含矫味剂、甜味剂和压缩助剂(润滑剂等)。
片剂中所含的多磷酸盐选自三聚磷酸钠、三聚磷酸钾、焦磷酸钠、三偏磷酸钠和六偏磷酸钠。
片剂还可以含有不与多磷酸盐相互作用的其它活性成分，例如维生素。片剂优选不含矿物盐。
作为例子，制备根据以下配方的硬片剂：
通过已知方法用直接压片法获得每片重700mg的片剂。
根据定量描述分析技术，由十三名专家品尝者小组比较实施例1和实施例2的产品的粗糙度。品尝者在不同的时间对实施例1和2各盲试一个片剂。要求他们吸吮片剂3分钟，并立即和在吸吮片剂后每过一分钟以VAS等级从0(光滑)至100(粗糙)对其粗糙度评分。评分如下所示：
由于产品较好的适口性，因此可以包含优选占片剂总重量0.5％-3％重量，优选0.6％-2％重量的多磷酸盐，以使片剂的使用成为减少牙齿色斑形成的有效方法，这是本发明的另一方面。
通过涉及六十名志愿者的功效测试证明了牙齿色斑形成的减少，所述志愿者在与未处理(对照)相比的交叉程序中测试了实施例2和3的产品。该测试持续12周，在测试开始时，志愿者在牙科手术中清洁其牙齿以确保初始的牙齿色斑水平总计为零。然后他们每天使用四次、每次2片片剂(实施例2和3)或不使用片剂(对照)。12周后通过改进的Lobene色斑指数方法测量门牙的色斑，计算扩展x强度的综合指数。因此，可以计算与对照相比色斑形成减少的百分比，其值示于下表中。在该阶段结束时，对志愿者询问片剂的适口性。测试结果如下所示：
表1
如表中所示，本发明的产品能够减少牙齿色斑的形成。没有参与者退出测试，并且所有的参与者都报告片剂的适口性是可接受的。
Claims (7)
1.包含微粉化多磷酸盐和一种或多种多元醇的片剂，其中所述多磷酸盐至少有90％重量的颗粒具有低于150μm的直径。
2.通过直接压制获得的权利要求1的片剂。
3.根据权利要求1或2的片剂，其中多磷酸盐以总产物或片剂的0.5％-3％重量的百分比存在。
4.根据权利要求1-3中任一项的片剂，其中所述多磷酸盐选自三聚磷酸钠、三聚磷酸钾、焦磷酸钠、三偏磷酸钠和六偏磷酸钠。
5.根据权利要求1-4中任一项的片剂，其中超过90％重量的微粉化多磷酸盐颗粒具有低于106μm的直径，更优选超过80％重量的颗粒具有低于53μm的直径。
6.根据权利要求1-5中任一项的片剂，其中所述多元醇为山梨醇，其百分比范围为80-98重量％。
7.权利要求1-6的片剂在减少牙齿色斑形成中的用途。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102018000005426 | 2018-05-16 | ||
| IT201800005426A IT201800005426A1 (it) | 2018-05-16 | 2018-05-16 | Prodotto di confetteria contenente polifosfati |
| PCT/IB2019/054065 WO2019220389A1 (en) | 2018-05-16 | 2019-05-16 | Tablets containing polyphosphates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112105269A true CN112105269A (zh) | 2020-12-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980031782.6A Pending CN112105269A (zh) | 2018-05-16 | 2019-05-16 | 含有多磷酸盐的片剂 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20210220239A1 (zh) |
| EP (1) | EP3793374A1 (zh) |
| JP (1) | JP2021523203A (zh) |
| CN (1) | CN112105269A (zh) |
| AU (1) | AU2019268582A1 (zh) |
| BR (1) | BR112020023365A2 (zh) |
| CA (1) | CA3097796A1 (zh) |
| IT (1) | IT201800005426A1 (zh) |
| MX (1) | MX2020012194A (zh) |
| WO (1) | WO2019220389A1 (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023164863A1 (en) * | 2022-03-03 | 2023-09-07 | Mars Wrigley Confectionery (China) Limited | Deep cleaning chewing gum |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5180576A (en) * | 1991-08-30 | 1993-01-19 | Church & Dwight Co., Inc. | Anticalculus dentifrices |
| US20030003219A1 (en) * | 2001-05-15 | 2003-01-02 | The Procter & Gamble Company | Confectionery compositions |
| US20030008062A1 (en) * | 2001-05-15 | 2003-01-09 | Day Trevor Neil | Confectionery compositions |
| US6685916B1 (en) * | 2002-10-31 | 2004-02-03 | Cadbury Adams Usa Llc | Compositions for removing stains from dental surfaces, and methods of making and using the same |
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| US4806340A (en) * | 1985-09-13 | 1989-02-21 | Colgate-Palmolive Company | Anticalculus oral composition |
| IN168400B (zh) * | 1987-01-30 | 1991-03-23 | Colgate Palmolive Co | |
| CH678850A5 (zh) * | 1989-07-17 | 1991-11-15 | Jean Paul Atdjian | |
| US5702687A (en) * | 1995-10-03 | 1997-12-30 | Church & Dwight Co., Inc. | Chewing gum product with plaque-inhibiting benefits |
| JPH10182389A (ja) * | 1996-12-27 | 1998-07-07 | Lion Corp | 歯磨組成物 |
| EP1227789B1 (en) * | 1999-11-12 | 2004-09-22 | The Procter & Gamble Company | Improved dual phase stannous oral compositions |
| US6416744B1 (en) * | 2001-06-21 | 2002-07-09 | Colgate Palmolive Company | Tooth whitening chewing gum |
| JP4627999B2 (ja) * | 2004-02-27 | 2011-02-09 | 太陽化学株式会社 | 坑酸化剤 |
| US20060024245A1 (en) * | 2004-07-29 | 2006-02-02 | Cadbury Adams, Llc. | Tooth whitening compositions and delivery systems therefor |
| ES2442253T3 (es) * | 2007-02-23 | 2014-02-10 | The Procter & Gamble Company | Composiciones orales de polifosfato |
| MX2017008535A (es) * | 2014-12-24 | 2018-03-23 | Univ Melbourne | Composiciones de fluoruro de mineralización. |
| MX2018005200A (es) * | 2015-10-26 | 2018-07-06 | Basf Se | Productos para el cuidado bucal y procedimientos que comprenden polipeptidos de union a hidroxiapatita (habp). |
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2018
- 2018-05-16 IT IT201800005426A patent/IT201800005426A1/it unknown
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2019
- 2019-05-16 CN CN201980031782.6A patent/CN112105269A/zh active Pending
- 2019-05-16 AU AU2019268582A patent/AU2019268582A1/en active Pending
- 2019-05-16 WO PCT/IB2019/054065 patent/WO2019220389A1/en active Application Filing
- 2019-05-16 EP EP19730954.5A patent/EP3793374A1/en active Pending
- 2019-05-16 CA CA3097796A patent/CA3097796A1/en active Pending
- 2019-05-16 MX MX2020012194A patent/MX2020012194A/es unknown
- 2019-05-16 JP JP2020564194A patent/JP2021523203A/ja active Pending
- 2019-05-16 BR BR112020023365-0A patent/BR112020023365A2/pt not_active Application Discontinuation
- 2019-05-16 US US17/055,192 patent/US20210220239A1/en active Pending
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| US5180576A (en) * | 1991-08-30 | 1993-01-19 | Church & Dwight Co., Inc. | Anticalculus dentifrices |
| US20030003219A1 (en) * | 2001-05-15 | 2003-01-02 | The Procter & Gamble Company | Confectionery compositions |
| US20030008062A1 (en) * | 2001-05-15 | 2003-01-09 | Day Trevor Neil | Confectionery compositions |
| US6685916B1 (en) * | 2002-10-31 | 2004-02-03 | Cadbury Adams Usa Llc | Compositions for removing stains from dental surfaces, and methods of making and using the same |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2023164863A1 (en) * | 2022-03-03 | 2023-09-07 | Mars Wrigley Confectionery (China) Limited | Deep cleaning chewing gum |
Also Published As
| Publication number | Publication date |
|---|---|
| US20210220239A1 (en) | 2021-07-22 |
| EP3793374A1 (en) | 2021-03-24 |
| IT201800005426A1 (it) | 2019-11-16 |
| MX2020012194A (es) | 2021-01-29 |
| AU2019268582A1 (en) | 2020-11-26 |
| CA3097796A1 (en) | 2019-11-21 |
| BR112020023365A2 (pt) | 2021-02-09 |
| JP2021523203A (ja) | 2021-09-02 |
| WO2019220389A1 (en) | 2019-11-21 |
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