CN112074267B - 成纤维细胞结合剂及其用途 - Google Patents

成纤维细胞结合剂及其用途 Download PDF

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CN112074267B
CN112074267B CN201980024632.2A CN201980024632A CN112074267B CN 112074267 B CN112074267 B CN 112074267B CN 201980024632 A CN201980024632 A CN 201980024632A CN 112074267 B CN112074267 B CN 112074267B
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seq
amino acid
acid sequence
fap
cdr1
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CN112074267A (zh
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N·克雷
J·塔威尼尔
A·考威尔斯
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Universiteit Gent
Vlaams Instituut voor Biotechnologie VIB
Orinis Bioscience Co ltd
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Universiteit Gent
Vlaams Instituut voor Biotechnologie VIB
Orinis Bioscience Co ltd
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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CN201980024632.2A 2018-02-05 2019-02-05 成纤维细胞结合剂及其用途 Active CN112074267B (zh)

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US201862626453P 2018-02-05 2018-02-05
US62/626,453 2018-02-05
PCT/US2019/016629 WO2019152979A1 (en) 2018-02-05 2019-02-05 Fibroblast binding agents and use thereof

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JP (2) JP2021513361A (enExample)
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AU (2) AU2019215440B2 (enExample)
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JP7512413B2 (ja) * 2020-03-31 2024-07-08 ビオテウス・インコーポレイテッド 抗ｐｄ－ｌ１およびｐｄ－ｌ２抗体ならびにその誘導体および用途
JP2023541601A (ja) * 2020-09-10 2023-10-03 プレシリックス・ナームローゼ・ベンノートシヤープ Ｆａｐに対する抗体フラグメント
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CN114853909A (zh) * 2022-05-13 2022-08-05 南京吉盛澳玛生物医药有限公司 新型IL-2与INFα和Fc融合蛋白的设计、制备及用途
CN117448412A (zh) * 2022-07-26 2024-01-26 中山大学孙逸仙纪念医院 CD158d分子、其中和抗体，及应用
WO2025034806A1 (en) * 2023-08-08 2025-02-13 Wisconsin Alumni Research Foundation Single-domain antibodies and variants thereof against fibroblast activation protein
WO2025068413A1 (en) * 2023-09-28 2025-04-03 Prokarium Limited Interleukin 18 variants
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WO2025172588A1 (en) * 2024-02-16 2025-08-21 Mestag Therapeutics Ltd Bispecific constructs directed against fap and ltbr
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KR20250134312A (ko) * 2024-03-04 2025-09-11 한국과학기술원 암　관련 섬유아세포를 이용한 암 진단 또는 치료 방법
KR20250134315A (ko) * 2024-03-04 2025-09-11 한국과학기술원 면역항암치료의 효과가 예상되는 환자군 선별 방법
CN118995547B (zh) * 2024-08-02 2025-12-19 深圳湾实验室 工程化大肠杆菌及其应用
CN119859615A (zh) * 2024-12-31 2025-04-22 广州安捷生物医学技术有限公司 一种靶向成纤维细胞激活蛋白的car-msc细胞及其制备方法和应用

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