CN112043790A - Lung yin deficiency type xerophthalmia fumigation liquid and preparation method thereof - Google Patents
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Abstract
The invention discloses a lung yin deficiency type xerophthalmia fumigation solution and a preparation method thereof, belonging to the technical field of traditional Chinese medicine extraction, the lung yin deficiency type xerophthalmia fumigation solution comprises 1-50 parts of radix rehmanniae, 1-50 parts of radix ophiopogonis, 1-50 parts of radix scrophulariae, 1-50 parts of radix paeoniae alba, 1-50 parts of cortex moutan, 1-50 parts of folium mori and 1-50 parts of chrysanthemum, the fumigation solution of the scheme is mainly used for treating lung yin deficiency type xerophthalmia, the pain of oral administration is effectively avoided, the extracted liquid can be changed into steam through a fumigation instrument to be directly contacted with eyes, the treatment effect is stronger, meanwhile, the oxidation and the dissipation of heat-sensitive substances are effectively prevented, the effective components of traditional Chinese medicinal materials are well kept in an extract, in addition, toxic and harmful organic solvents are not used in the whole process, only ethanol with different concentrations is used as a modifier, no residual toxic and harmful solvent substances exist in the extract, so that the existence of a human body and the pollution to the environment in the extraction process are, ensuring 100 percent of pure naturalness.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine extraction, and particularly relates to lung yin deficiency type xerophthalmia fumigation liquid and a preparation method thereof.
Background
The traditional Chinese medicine is a traditional medicine in China, and is valued by various countries in the world based on the characteristics of abundant resources, unique curative effect and the like. Meanwhile, compared with traditional Chinese medicines, the traditional Chinese medicine has stronger toxic and side effects, so that the efficient extraction of the effective components of the traditional Chinese medicines is very important. The traditional method for extracting the effective components of the traditional Chinese medicine mainly comprises the following steps: impregnation, precooking, reflux extraction, steam distillation, distillation under reduced pressure, sublimation, etc. The methods have the defects of complex extraction process, low product purity, organic residue, easy damage to heat-sensitive substances and the like. The Supercritical Fluid Extraction (SFE) has the advantages of low energy consumption, simple process flow, no environmental pollution, easily controlled parameters, high Extraction efficiency, good product purity and the like. Meanwhile, the method is suitable for separating and extracting volatile components and fat-soluble components which are unstable and easy to oxidize. Based on the advantages, the SFE is widely applied to the extraction process of effective components such as volatile oils, alkaloids, saponins, polysaccharides, ketones and the like in the traditional Chinese medicine.
However, the existing lung yin deficiency type xerophthalmia treatment traditional Chinese medicine is usually prepared into pills or decoction for oral administration, and for some people, the prepared pills are not easy to take orally, vomit can occur in the taking process, so that pain is brought to the user, the pills are small in diameter and easy to lose, waste is caused, the packaging cost is higher, the prepared decoction is smelly, the taste is bitter, the medicine taking difficulty also exists, and unnecessary waste is caused by the pouring of the decoction.
Disclosure of Invention
1. Technical problem to be solved
In view of the problems in the prior art, a first object of the present invention is to provide a lung-yin-deficiency-type dry eye fumigation solution, which can effectively treat dry eyes, especially treat dry eyes due to lung-yin deficiency;
the second invention aims to provide a preparation method of lung yin deficiency type dry eye fumigation solution, and modifiers with different concentrations are selectively added according to different types of traditional Chinese medicinal materials during preparation, so that each medicinal material has the concentration of the modifier for promoting the extraction rate of each medicinal material, and the obtained fumigation solution has a better extraction effect.
2. Technical scheme
In order to solve the above problems, the present invention adopts the following technical solutions.
A lung yin deficiency type xerophthalmia fumigation solution contains active ingredients which are synchronously extracted from the following traditional Chinese medicinal materials in parts by weight by an SFE extraction method in every 100 parts by volume of ethanol with the concentration of 20-95 percent:
further, the active ingredients comprise the following components in parts by weight:
a preparation method of a lung yin deficiency type dry eye fumigation solution comprises the following steps: firstly, taking the various medicinal materials, respectively drying and crushing the medicinal materials to 20-40 meshes, then weighing the medicinal materials in proper weight, and introducing the weighed medicinal materials into an extraction kettle for mixing;
secondly, adjusting the pressure of an extraction kettle to be 20-50 MPa, the temperature to be 15-60 ℃, the pressure of a separation kettle to be 6-15 MPa and the temperature to be 20-45 ℃, and performing supercritical fluid extraction for 1.5-5 hours by taking carbon dioxide as a medium to obtain a first extraction liquid from the separation kettle;
thirdly, regulating the pressure of the extraction kettle to be 20-50 MPa, the temperature to be 15-60 ℃, the pressure of the separation kettle to be 6-15 MPa and the temperature to be 20-45 ℃, performing supercritical fluid extraction for 1.5-5 hours by taking a modifier as a medium, and obtaining a second extraction liquid from the separation kettle;
and step four, mixing and shaking the first extract liquid obtained in the step two and the second extract liquid obtained in the step three evenly to obtain the fumigation liquid.
Further, the modifier in the third step is 20-95% of ethanol.
Further, the preparation method of the fumigation liquid comprises the following steps:
firstly, taking the various medicinal materials, respectively drying and crushing the medicinal materials to 20-40 meshes, then weighing the medicinal materials in proper weight, and introducing the weighed medicinal materials into an extraction kettle for mixing;
secondly, adjusting the pressure of an extraction kettle to be 20-50 MPa, the temperature to be 15-60 ℃, the pressure of a separation kettle to be 6-15 MPa and the temperature to be 20-45 ℃, and performing supercritical fluid extraction for 1.5-5 hours by taking carbon dioxide as a medium to obtain a first extraction liquid from the separation kettle;
thirdly, regulating the pressure of an extraction kettle to be 20-50 MPa, the temperature to be 15-60 ℃, the pressure of a separation kettle to be 6-15 MPa and the temperature to be 20-45 ℃, respectively taking 20%, 60%, 80% and 95% ethanol as media to perform supercritical fluid extraction for 1.5-5 h, and mixing the extraction liquid obtained from the separation kettle each time to obtain a second extraction liquid;
and step four, mixing and shaking the first extract liquid obtained in the step two and the second extract liquid obtained in the step three evenly to obtain the fumigation liquid.
Further, the 20% ethanol is suitable for extracting polysaccharide traditional Chinese medicines: folium Mori.
Further, the 60% ethanol is suitable for extracting alkaloid traditional Chinese medicines: radix scrophulariae.
Further, the 80% ethanol is suitable for extracting flavonoid traditional Chinese medicines: and (5) chrysanthemum.
Further, the 95% ethanol is suitable for extracting saponin traditional Chinese medicines: radix rehmanniae, radix Ophiopogonis, and radix Paeoniae alba.
Further, the preparation method of the fumigation liquid comprises the following steps:
firstly, taking the various medicinal materials, respectively drying and crushing the medicinal materials to 35-40 meshes, then weighing the medicinal materials in proper weight, and introducing the weighed medicinal materials into an extraction kettle for mixing;
secondly, adjusting the pressure of an extraction kettle to be 20-30 MPa, the temperature to be 45-50 ℃, the pressure of a separation kettle to be 6-10 MPa and the temperature to be 30-45 ℃, and performing supercritical fluid extraction for 2-3 hours by taking carbon dioxide as a medium to obtain a first extraction liquid from the separation kettle;
thirdly, regulating the pressure of an extraction kettle to be 30-35 MPa, the temperature to be 35-60 ℃, the pressure of a separation kettle to be 6-8 MPa and the temperature to be 20-40 ℃, respectively taking 20%, 60%, 80% and 95% ethanol as media to perform supercritical fluid extraction for 1.5-3 h, and mixing the extraction liquid obtained from the separation kettle each time to obtain a second extraction liquid;
and step four, mixing and shaking the first extract liquid obtained in the step two and the second extract liquid obtained in the step three evenly to obtain the fumigation liquid.
3. Advantageous effects
Compared with the prior art, the invention has the advantages that:
firstly, the fumigation liquid of this scheme mainly aims at the treatment of lung yin deficiency type xerophthalmia, effectively avoids the misery of taking orally, and the liquid of extraction can become steam through stifling appearance and directly contacts with the eye, and therapeutic effect is stronger, has effectively prevented the oxidation and the loss of heat sensitive material simultaneously, has kept the active ingredient of chinese-medicinal material well in the extract.
Secondly, no toxic and harmful organic solvent is used in the whole process, only ethanol with different concentrations is used as a modifier, and the extract has no residual toxic and harmful solvent substances, so that the existence of harmful substances to human bodies and the pollution to the environment in the extraction process are prevented, and the pure natural property of 100 percent is ensured.
Detailed Description
The technical scheme in the embodiment of the invention is clearly and completely described below; obviously; the described embodiments are only some of the embodiments of the invention; but not all embodiments, are based on the embodiments of the invention; all other embodiments obtained by a person skilled in the art without making any inventive step; all fall within the scope of protection of the present invention.
Example 1:
prescription: 12 parts of radix rehmanniae, 10 parts of radix ophiopogonis, 15 parts of radix scrophulariae, 9 parts of radix paeoniae alba, 9 parts of cortex moutan, 6 parts of folium mori and 16 parts of chrysanthemum.
Respectively crushing the medicinal materials to 20-40 meshes, weighing according to the parts by weight, uniformly mixing in an extraction kettle after the crushing, firstly adjusting the pressure of the extraction kettle to 25MPa, the temperature to 50 ℃, the pressure of a separation kettle to 6MPa, the temperature to 40 ℃, and carrying out supercritical fluid extraction for 3h by taking carbon dioxide as a medium, thus obtaining a first extraction liquid from the separation kettle.
Then adjusting the pressure of an extraction kettle to 35MPa, the temperature to 45 ℃, the pressure of a separation kettle to 6MPa, the temperature to 20 ℃, and performing supercritical fluid extraction for 2h by using 20% ethanol as a medium to obtain an extract I; then, regulating the pressure of an extraction kettle to be 30MPa, the temperature to be 40 ℃, the pressure of a separation kettle to be 6MPa, the temperature to be 30 ℃, and performing supercritical fluid extraction for 3 hours by taking 60% ethanol as a medium to obtain an extraction liquid II; then regulating the pressure of an extraction kettle to 35MPa, the temperature to 54 ℃, the pressure of a separation kettle to 7MPa, the temperature to 45 ℃, and carrying out supercritical fluid extraction for 3h by taking 80% ethanol as a medium to obtain an extract III; finally, regulating the pressure of an extraction kettle to 35MPa, the temperature to 45 ℃, the pressure of a separation kettle to 6MPa, the temperature to 20 ℃, and performing supercritical fluid extraction for 3h by taking 95% ethanol as a medium to obtain an extract IV; and mixing and shaking the extract I, the extract II, the extract III and the extract IV evenly to obtain a second extract, wherein the extraction rate is 92.5 percent.
And uniformly mixing the first extract and the second extract to obtain the fumigating liquid for treating lung-yin deficiency type xerophthalmia.
Example 2:
prescription: 12 parts of radix rehmanniae, 10 parts of radix ophiopogonis, 15 parts of radix scrophulariae, 9 parts of radix paeoniae alba, 9 parts of cortex moutan, 6 parts of folium mori and 16 parts of chrysanthemum.
Respectively crushing the medicinal materials to 20-40 meshes, weighing according to the parts by weight, uniformly mixing in an extraction kettle after the crushing, firstly adjusting the pressure of the extraction kettle to 25MPa, the temperature to 50 ℃, the pressure of a separation kettle to 6MPa, the temperature to 40 ℃, and carrying out supercritical fluid extraction for 3h by taking carbon dioxide as a medium, thus obtaining a first extraction liquid from the separation kettle.
And then adjusting the pressure of an extraction kettle to 35MPa, the temperature to 45 ℃, the pressure of a separation kettle to 6MPa, the temperature to 20 ℃, and performing supercritical fluid extraction for 3h by using 20% ethanol as a medium to obtain a second extract, wherein the extraction rate is 78.0%.
And uniformly mixing the first extract and the second extract to obtain the fumigating liquid for treating lung-yin deficiency type xerophthalmia.
Example 3:
prescription: 12 parts of radix rehmanniae, 10 parts of radix ophiopogonis, 15 parts of radix scrophulariae, 9 parts of radix paeoniae alba, 9 parts of cortex moutan, 6 parts of folium mori and 16 parts of chrysanthemum.
Respectively crushing the medicinal materials to 20-40 meshes, weighing according to the parts by weight, uniformly mixing in an extraction kettle after the crushing, firstly adjusting the pressure of the extraction kettle to 25MPa, the temperature to 50 ℃, the pressure of a separation kettle to 6MPa, the temperature to 40 ℃, and carrying out supercritical fluid extraction for 3h by taking carbon dioxide as a medium, thus obtaining a first extraction liquid from the separation kettle.
And adjusting the pressure of an extraction kettle to be 30MPa, the temperature to be 40 ℃, the pressure of a separation kettle to be 6MPa and the temperature to be 30 ℃, and performing supercritical fluid extraction for 3 hours by taking 60% ethanol as a medium to obtain a second extraction liquid, wherein the extraction rate is 87.1%.
And uniformly mixing the first extract and the second extract to obtain the fumigating liquid for treating lung-yin deficiency type xerophthalmia.
Example 4:
prescription: 12 parts of radix rehmanniae, 10 parts of radix ophiopogonis, 15 parts of radix scrophulariae, 9 parts of radix paeoniae alba, 9 parts of cortex moutan, 6 parts of folium mori and 16 parts of chrysanthemum.
Respectively crushing the medicinal materials to 20-40 meshes, weighing according to the parts by weight, uniformly mixing in an extraction kettle after the crushing, firstly adjusting the pressure of the extraction kettle to 25MPa, the temperature to 50 ℃, the pressure of a separation kettle to 6MPa, the temperature to 40 ℃, and carrying out supercritical fluid extraction for 3h by taking carbon dioxide as a medium, thus obtaining a first extraction liquid from the separation kettle.
And adjusting the pressure of an extraction kettle to 35MPa, the temperature to 54 ℃, the pressure of a separation kettle to 7MPa, the temperature to 45 ℃, and performing supercritical fluid extraction for 3h by taking 80% ethanol as a medium to obtain a second extract, wherein the extraction rate is 85.0%.
And uniformly mixing the first extract and the second extract to obtain the fumigating liquid for treating lung-yin deficiency type xerophthalmia.
Example 5:
prescription: 12 parts of radix rehmanniae, 10 parts of radix ophiopogonis, 15 parts of radix scrophulariae, 9 parts of radix paeoniae alba, 9 parts of cortex moutan, 6 parts of folium mori and 16 parts of chrysanthemum.
Respectively crushing the medicinal materials to 20-40 meshes, weighing according to the parts by weight, uniformly mixing in an extraction kettle after the crushing, firstly adjusting the pressure of the extraction kettle to 25MPa, the temperature to 50 ℃, the pressure of a separation kettle to 6MPa, the temperature to 40 ℃, and carrying out supercritical fluid extraction for 3h by taking carbon dioxide as a medium, thus obtaining a first extraction liquid from the separation kettle.
And adjusting the pressure of an extraction kettle to 35MPa, the temperature to 45 ℃, the pressure of a separation kettle to 6MPa, the temperature to 20 ℃, and performing supercritical fluid extraction for 3 hours by using 95% ethanol as a medium to obtain a second extract, wherein the extraction rate is 74.3%.
And uniformly mixing the first extract and the second extract to obtain the fumigating liquid for treating lung-yin deficiency type xerophthalmia.
Comparative example:
through the analysis, the fact that the extraction of different types of traditional Chinese medicinal materials is performed by specifically adopting ethanol with different concentrations is found that the obtained extraction rate is highest, and the extraction rate of polysaccharide traditional Chinese medicine mulberry leaves is best when ethanol with certain concentration is singly adopted, such as 20% ethanol, while the extraction rate of other types of traditional Chinese medicines is not good.
The above; but are merely preferred embodiments of the invention; the scope of the invention is not limited thereto; any person skilled in the art is within the technical scope of the present disclosure; the technical scheme and the improved concept of the invention are equally replaced or changed; are intended to be covered by the scope of the present invention.
Claims (5)
1. The lung yin deficiency type xerophthalmia fumigation liquid is characterized in that: every 100 volume parts of ethanol with the concentration of 20-95% contains active ingredients synchronously extracted from the following traditional Chinese medicinal materials by an SFE extraction method:
2. the fumigation solution for lung yin deficiency type dry eye according to claim 1, wherein:
3. the fumigation solution for lung yin deficiency type dry eye according to claim 2, wherein:
4. the preparation method of the lung-yin-deficiency-type dry eye fumigation solution as claimed in claim 1, wherein: the method comprises the following steps:
firstly, taking various medicinal materials in claim 1, respectively drying and crushing the medicinal materials to 20-40 meshes, then weighing proper weight, and guiding the weighed medicinal materials into an extraction kettle for mixing;
secondly, adjusting the pressure of an extraction kettle to be 20-50 MPa, the temperature to be 15-60 ℃, the pressure of a separation kettle to be 6-15 MPa and the temperature to be 20-45 ℃, and performing supercritical fluid extraction for 1.5-5 hours by taking carbon dioxide as a medium to obtain a first extraction liquid from the separation kettle;
thirdly, regulating the pressure of the extraction kettle to be 20-50 MPa, the temperature to be 15-60 ℃, the pressure of the separation kettle to be 6-15 MPa and the temperature to be 20-45 ℃, performing supercritical fluid extraction for 1.5-5 hours by taking a modifier as a medium, and obtaining a second extraction liquid from the separation kettle;
and step four, mixing and shaking the first extract liquid obtained in the step two and the second extract liquid obtained in the step three evenly to obtain the fumigation liquid.
5. The preparation method of the lung-yin-deficiency-type dry eye fumigation solution as claimed in claim 4, wherein: and the modifier is 20-95% ethanol.
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| CN113197971A (en) * | 2021-04-21 | 2021-08-03 | 刘昳 | Fomenting bag for treating eye diseases caused by yin deficiency and dryness-heat syndrome and preparation method thereof |
| CN113797276A (en) * | 2021-11-08 | 2021-12-17 | 普润德百目通(北京)科技有限公司 | Novel eye disease fumigation treatment medicament |
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