CN112022788A - 一种防脱发植物提取物及其制备方法和应用 - Google Patents
一种防脱发植物提取物及其制备方法和应用 Download PDFInfo
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- CN112022788A CN112022788A CN202011119786.0A CN202011119786A CN112022788A CN 112022788 A CN112022788 A CN 112022788A CN 202011119786 A CN202011119786 A CN 202011119786A CN 112022788 A CN112022788 A CN 112022788A
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- alopecia
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Abstract
本发明公开了一种防脱发植物提取物,所述植物提取物的制备原料选自姜、红车轴草、獐牙菜、侧柏叶、艾叶、虎杖、黄芪中的至少两种。所述植物组合物具有协同增效作用,多通路、多靶点达到防脱效果,作用机理主要包括增强毛乳头细胞的自噬活性、促进毛乳头细胞增殖。另外,本发明提供的植物组合物还具有显著的控油功效,通过抑制头皮油脂分泌达到防脱发效果和清爽舒适的使用感。
Description
技术领域
本发明涉及植物提取物技术领域,尤其涉及一种防脱发植物提取物及其制备方法和应用。
背景技术
脱发是临床常见疾病,可分为斑秃、脂溢性脱发、化疗性脱发、老年性脱发等类型,其中脂溢性脱发和斑秃发病率最高。目前市面上的防脱发产品作用机理比较单一,难以实现标本兼治。
防脱发效果最好的是西药米诺地尔和非那雄胺,但长期使用会有明显的副作用,其中非那雄胺会造成瘙痒、风疹及面部肿胀等过敏反应,女士使用会导致婴儿的出生缺陷及性功能障碍,米诺地尔对于女性易造成严重的脸部和四肢多毛症,用药部分易发生干燥、脱屑、瘙痒、发红等刺激性反应,还有可能造成某些心血管系统的不良反应。植物来源的防脱发成分安全无毒,但由于配方不合理或不合适的制备工艺导致功效普遍不够理想,且植物提取物还会存在稳定性问题。
发明内容
为了解决上述问题,本发明的第一方面提供了一种防脱发植物提取物,所述植物提取物的制备原料包括姜、红车轴草、獐牙菜、侧柏叶、艾叶、虎杖、黄芪中的至少两种。
作为一种优选的技术方案,按重量份计,所述植物提取物的制备原料包括:生姜10~50份或干姜4~20份、红车轴草1~10份、獐牙菜3~15份、侧柏叶3~15份、艾叶0.5~5份、虎杖1~10份、黄芪1~5份。
作为一种优选的技术方案,按重量份计,所述植物提取物的制备原料包括:生姜20~40份或干姜6~12份、红车轴草2~5份、獐牙菜5~10份、侧柏叶5~10份、艾叶1~3份、虎杖2~5份、黄芪2~4份。
本发明的第二方面提供了一种如上所述的防脱发植物提取物的制备方法,包括以下步骤:
a.提取生姜或干姜;
b.混合提取除生姜或干姜以外的剩余原料;
c.合并步骤a和步骤b中得到的产物,即得。
作为一种优选的技术方案,所述步骤a中,生姜的提取包括以下步骤:
a-1.生姜经物理压榨,得到汁液;
a-2.向上述汁液中加入多元醇A,冷藏,过滤,得到第一滤液;
a-3.将上述滤液进行超滤,收集第一超滤液。
干姜的提取方法为:干姜与多元醇A混合,超声提取,提取液进行超滤,收集第二超滤液。
作为一种优选的技术方案,所述多元醇A选自乙二醇、丙二醇、1,3-丙二醇、丁二醇、甘油、二丙二醇中的一种或多种的混合。
作为一种优选的技术方案,所述步骤b包括:
b-1.混合除生姜或干姜以外的剩余原料,粉碎,过筛,得到混合物;
b-2.向上述混合物中加入体积比(0.5~1.5):1的多元醇B和水的混合溶剂,将pH调至2.0-3.0,提取,收集提取液;
b-3.向b-2的药渣加入体积比(0.5~1.5):1的多元醇B和水的混合溶剂,将pH调至7.5-8.0,提取,收集提取液;
b-4.将b-2和b-3的提取液混合,加入澄清剂,搅拌均匀后静置1小时,过滤,得到第二滤液。
作为一种优选的技术方案,所述多元醇B选自乙二醇、丙二醇、1,3-丙二醇、丁二醇、甘油、二丙二醇中的一种或多种的混合。
本发明的第三方面提供了一种如上所述的防脱发植物提取物的应用,其用于头部洗护产品。
作为一种优选的技术方案,如上所述的防脱发植物提取物还用于皮肤控油、抑痘产品。
有益效果:本发明提供了一种防脱发植物提取物及其制备方法和应用,所述植物组合物具有协同增效作用,多通路、多靶点达到防脱效果,作用机理主要包括增强毛乳头细胞的自噬活性、促进毛乳头细胞增殖、促进头部血液循环,通过这些机理增强毛乳头细胞的活力、延缓毛囊细胞的退化,从根本上解决脱发问题。另外,本发明提供的植物组合物还具有显著的控油功效,通过抑制头皮油脂分泌达到防脱发效果和清爽舒适的使用感。
附图说明
为了进一步解释说明本发明中提供的一种防脱发植物提取物及其制备方法和应用的有益效果,提供了相应的附图,需要指出的是本发明中提供的附图只是所有附图中选出来的个别示例,目的也不是作为对权利要求的限定,所有通过本申请中提供的附图获得的其他相应图谱均应该认为在本申请保护的范围之内。
图1为本发明实施例1增强毛乳头细胞自噬活性的测试结果。
图2为本发明实施例1促进毛乳头细胞增殖作用的测试结果。
图3为本发明实施例1的控油功效测试结果。
具体实施方式
结合以下本发明的优选实施方法的详述以及包括的实施例可进一步地理解本发明的内容。除非另有说明,本文中使用的所有技术及科学术语均具有与本申请所属领域普通技术人员的通常理解相同的含义。如果现有技术中披露的具体术语的定义与本申请中提供的任何定义不一致,则以本申请中提供的术语定义为准。
在本文中使用的,除非上下文中明确地另有指示,否则没有限定单复数形式的特征也意在包括复数形式的特征。还应理解的是,如本文所用术语“由…制备”与“包含”同义,“包括”、“包括有”、“具有”、“包含”和/或“包含有”,当在本说明书中使用时表示所陈述的组合物、步骤、方法、制品或装置,但不排除存在或添加一个或多个其它组合物、步骤、方法、制品或装置。此外,当描述本申请的实施方式时,使用“优选的”、“优选地”、“更优选的”等是指,在某些情况下可提供某些有益效果的本发明实施方案。然而,在相同的情况下或其他情况下,其他实施方案也可能是优选的。除此之外,对一个或多个优选实施方案的表述并不暗示其他实施方案不可用,也并非旨在将其他实施方案排除在本发明的范围之外。
为了解决上述问题,本发明的第一方面提供了一种防脱发植物提取物,所述植物提取物的制备原料包括姜、红车轴草、獐牙菜、侧柏叶、艾叶、虎杖、黄芪中的至少两种。
在一些优选的实施方式中,按重量份计,所述植物提取物的制备原料包括:生姜10~50份或干姜4~20份、红车轴草1~10份、獐牙菜3~15份、侧柏叶3~15份、艾叶0.5~5份、虎杖1~10份、黄芪1~5份。
在一些进一步优选的实施方式中,按重量份计,所述植物提取物的制备原料包括:生姜20~40份或干姜6~12份、红车轴草2~5份、獐牙菜5~10份、侧柏叶5~10份、艾叶1~3份、虎杖2~5份、黄芪2~4份。
姜,学名:Zingiber officinale Rosc.,分为生姜、干姜、炮姜。姜有助于药性上行,刺激头部毛囊。生姜为姜的新鲜根茎,性微温,味辛,归肺、脾、胃经,具有解表散寒、温中止呕、化痰止咳的功效。生姜含挥发性成分:α-姜烯(α-zingiberene),β-檀香萜醇(β-santalol),β-水芹烯(β-phellandrene),β-甜没药烯(β-bisabolene),α-姜黄烯(α-curcumene),姜醇(zingiberol),紫苏醛(perillaldehyde),橙花醛(neral),牻牛儿醛(geranial),2-蒈醇(2-caraneol),3-蒈醇,樟烯(camphene),β-罗勒烯(β-ocimene),α-香柑油烯(α-bergamotene),β-金便欢烯(β-farnesene),月桂烯(myrcene),β-蒎烯(β-pinene),2-龙脑(2-borneol),柠檬醛(citral),7-孟烯(7-menthene),异小茴香醇(isofenchyl alcohol)等数十种;还含有辛辣成分:6-姜辣醇(6-gingerol),3-姜辣醇,4-姜辣醇,5-姜辣醇,8-姜辣醇,10-姜辣醇,12-姜辣醇,6-姜辣二醇(6-gingediol),4-姜辣二醇,8-姜辣二醇,10-姜辣二醇,6-甲基姜辣二醇,4-姜辣二醇,8-姜辣二醇,10-姜辣二醇,6-甲基姜辣二醇(6-methylgingediol),4-姜辣二醇双乙酸酯(4-gingediacetate),6-姜辣二醇双乙酸酯,6-甲基姜二醇双乙酸(6-methylgingediacetate),6-姜辣二酮(6-gingerdione),10-姜辣二酮,6-去氢姜辣二酮(6-dehydrogingerdiong),10-去氢姜辣二酮,6-乙酰姜辣醇(6-acetylgingerol),6-姜辣烯酮(6-shogaol)等;还含天冬氨酸(aspartic acid),谷氨酸(glutamic acid),丝氨酸(serine)等多种氨基酸。
红车轴草,学名:Trifolium pratense L.,性微寒,味微甘、苦,归肺经,具有清热止咳、散结消肿等功效。红车轴草全草含多种黄酮类成分化合物:鹰嘴豆牙素(biochanin)A和B(即芒柄花素formononetin),染料木素(genistein),大豆素(daidzein),红车轴草素(pratensein),红车轴草素享(pratoletin),三叶豆紫檀甙(trifolirhizin),柳穿鱼甙(pectolinarin);花中含三叶豆甙(trifolin),异鼠李素(isorhamnetin),车轴草醇(pratol)等黄酮类成分,并含有水杨酸(salicylic acid),对羟基桂皮酸(p-hydroxycinnamic acid)及挥发油等;叶中含有叶酸(folic acid),亚叶酸(folinic acid),少量甾醇、甘油酯、磷脂、糖脂、烃类等成分;根中含有异黄酮化合物毛蕊异黄酮(calycosin),伪赝靛甙元(4-pseu-dobaptigenin),红车轴草素(pratensein),芒柄花素(formonp-netin),染料木素(genistein),鹰嘴豆芽素(biochanin)A六种和芒柄花甙(ononin),染料木甙(genistin)和罗思菌素(rothindin),半胱氨酸(L-cysteine),组氨酸(L-histidine),赖氨酸(L-lysine),天冬酸胺(L-asparagine),丝氨酸(serine),谷氨酸(L-giu-tamic acid),a-丙氨酸(a-alanine),蛋氨酸(methionine),亮氨酸(leucine)及色氨酸(tryptophane)等。
獐牙菜,学名:Swertia bimaculata(Sieb.et Zucc.)Hook.f.et Thoms.exC.B.Clark,又名当药,性寒,味苦,具有清湿热、健胃等功效。獐牙菜全草含异牡荆素(isovitexin)、异荭草素(ho-moorientin)、1,3-二羟基-4,5-二甲氧基呫吨酮(1,3-dihydroxy-4,5-dimethoxyxanthone)、1,3-二羟基-4,5-二甲氧基呫吨酮-1-O-β-D-吡喃葡萄糖甙(1,3-dihydroxy-4,5-dimethoxyxanthone-l-O-β-D-glucopyranoside)、1,3-二羟基-4,5-二甲氧基呫吨酮-3-O-β-D-吡喃葡萄糖甙(1,3-dihydroxy-4,5-dimethoxyxanthone-3-O-β-D-glucopyranoside)、当药苦甙(swertiamarin)、当药甙(swero-side)等。
侧柏,学名:PLatycladus orientalis(L.)Franco,侧柏叶性寒,味苦、涩,归肺、肝、脾经,具有凉血止血、生发乌发等功效。侧柏叶含挥发油0.6~1%,其中含侧柏烯、侧柏酮、小茴香酮、蒎烯、石竹烯等;还含有黄酮类,例如香橙素、槲皮素、杨梅树皮素、扁柏双黄酮、穗花杉双黄酮等;还含鞣质、树脂、维生素C等。
艾叶为菊科植物艾Artemisia argyi Lévl.et.Vant.的干燥叶,又名冰台、医草、灸草等。艾叶味苦、辛,性温,归肝脾肾经。艾叶的化学成分主要包括挥发油、黄酮类、萜类、苯丙素类、有机酸类、甾体和多糖类。其中黄酮和苯丙素类化合物的含量较高,主要有泽兰黄酮、棕矢车菊素、槲皮素、木犀草素、艾黄素、柚皮素、圣草酚、蒙花苷、咖啡酸、阿魏酸等。艾叶具有抗菌、抗病毒、止血、保肝利胆、抗氧化、镇痛抗炎、降血糖、免疫调节等多种药理作用。
虎杖,学名:Reynoutria japonica Houtt.,性微寒,味微苦,归肝、胆、肺经,具有祛风利湿、散瘀定痛、止咳化痰等功效。虎杖根和根茎含游离葸醌及蒽醌甙,主要为大黄素、大黄素甲醚和大黄酚,以及蒽甙A、蒽甙B。根中还含3,4’,5-三羟基芪-3-β-D-葡萄糖甙,另含鞣质和多糖。虎杖茎含鞣质3.3%、异槲皮甙、大黄素等,细枝含鞣质13.4%。
黄芪,学名Astragalus propinquus Schischkin,性温,味甘,归肺、脾经,具有补气固表、利尿脱毒、排脓、敛疮生肌等功效。黄芪根含2’,4’-二羟基-5,6-二甲氧基异黄酮(2’,4’-dihydroxy-5,6-dimethoxyisoflavone)、胆碱(choline)、甜菜碱(betaine)、氨基酸、蔗糖、葡萄糖醛酸及微量的叶酸。
发明人在仔细的研究中发现,姜、侧柏叶、艾叶可促进毛乳头细胞增殖、促进头部血液循环;红车轴草和虎杖具有优异的控油功效;姜、獐牙菜、黄芪可增强毛乳头细胞的自噬活性。这些植物协同作用,发挥显著的防脱发功效,从根本上解决脱发问题。此外,黄芪中的皂苷类成分具有表面活性作用,可增大其他难溶活性物(如黄酮、姜辣素)的提取率和溶解度,提升有效物质含量的同时,使植物提取物更稳定,溶液中无沉淀析出。
本发明的第二方面提供了一种如上所述的防脱发植物提取物的制备方法,包括以下步骤:
a.提取生姜或干姜;
b.混合提取除生姜或干姜以外的剩余原料;
c.合并步骤a和步骤b中得到的产物,即得。
在一些优选的实施方式中,所述步骤a中,生姜的提取包括以下步骤:
a-1.生姜经物理压榨,得到汁液;
a-2.向上述汁液中加入多元醇A,冷藏,过滤,得到第一滤液;
a-3.将上述滤液进行超滤,收集第一超滤液。
干姜的提取方法为:干姜与多元醇A混合,超声提取,提取液进行超滤,收集第二超滤液。
在一些优选的实施方式中,所述汁液与多元醇A的质量比为1:(2~6);进一步优选的,所述汁液与多元醇A的质量比为1:(3~5)。
在一些优选的实施方式中,所述冷藏的温度为-5~5℃,时间为3~7小时;进一步优选的,所述冷藏的温度为-4~4℃,时间为4~6小时。
在一些优选的实施方式中,所述干姜与多元醇A的质量比为1:(5~15);进一步优选的,所述干姜与多元醇A的质量比为1:(7~10)。
在一些优选的实施方式中,所述超声提取的功率为200~600W,超声时间10~30分钟;进一步优选的,超声功率为200~400W,时间10~15分钟。
发明人在研究中发现,生姜用物理压榨的方式提取、干姜超声提取,可避免热敏性物质的变性,极大地保留了生姜中的活性成分,使防脱发植物提取物的功效更显著。
在一些优选的实施方式中,所述超滤的截留分子量为1000~10000;进一步优选的,所述超滤的截留分子量为1500~8000;更进一步的,所述超滤的截留分子量为3000~5000。发明人在研发过程中发现,采用超滤技术能够去除提取液中的淀粉、鞣质等不稳定成分,提高植物提取物的稳定性和保质期。
从提高提取效率的角度考虑,在一些优选的实施方式中,所述多元醇A选自乙二醇、丙二醇、1,3-丙二醇、丁二醇、甘油、二丙二醇中的一种或多种的混合;进一步优选的,所述多元醇A选自1,3-丙二醇、丁二醇、甘油中的一种或多种的混合。
在一些优选的实施方式中,所述步骤b包括:
b-1.混合除生姜或干姜以外的剩余原料,粉碎,过筛,得到混合物;
b-2.向上述混合物中加入体积比(0.5~1.5):1的多元醇B和水的混合溶剂,将pH调至2.0-3.0,提取,收集提取液;
b-3.向b-2的药渣加入体积比(0.5~1.5):1的多元醇B和水的混合溶剂,将pH调至7.5-8.0,提取,收集提取液;
b-4.将b-2和b-3的提取液混合,加入澄清剂,搅拌均匀后静置1小时,过滤,得到第二滤液。
口服的药物,吸收到血液中发挥药效之前,需经过胃肠道的消化,即活性成分可能是经胃肠道转化的产物,而不是药物原型。发明人意外地发现,依据此原理,模拟人体胃肠道的pH环境提取姜以外的植物原料,得到的提取物防脱发效果更强。分别按照b-2、b-3所述的pH提取,效果最佳。
在一些优选的实施方式中,所述剩余原料粉碎后过20~60目筛;进一步优选的,所述剩余原料粉碎后过30~50目筛。
在一些优选的实施方式中,所述混合物与混合溶剂的质量比为1:(5~8);进一步优选的,所述混合物与混合溶剂的质量比为1:(6~7)。
在一些优选的实施方式中,所述提取的温度为50~80℃。时间为1~3小时;进一步优选的,所述提取的温度为60~70℃。时间为1.5~2.5小时。
在一些优选的实施方式中,所述多元醇B选自乙二醇、丙二醇、1,3-丙二醇、丁二醇、甘油、二丙二醇中的一种或多种的混合;进一步优选的,所述多元醇B为1,3-丙二醇或丁二醇。
在一些优选的实施方式中,所述澄清剂为II型ZTC 1+1天然澄清剂。澄清剂的用量为提取液的1~3wt%;进一步优选的,所述澄清剂的用量为提取液的1.5~2.5wt%。II型ZTC 1+1天然澄清剂可有效去除提取液中的蛋白、鞣质,保证提取液的稳定性。
本发明的第三方面提供了一种如上所述的防脱发植物提取物的应用,其用于头部洗护产品。
作为头部洗护产品的示例,可举例洗发水、头皮护理精华液等。
在另一些实施方式中,如上所述的防脱发植物提取物还用于皮肤控油、抑痘产品。
实施例
下面结合具体实施例对本发明进行详细说明。以下实施例将有助于本领域的技术人员进一步理解本发明,但不以任何形式限制本发明。应当指出的是,对本领域的普通技术人员来说,在不脱离本发明构思的前提下,还可以做出若干变形和改进。这些都属于本发明的保护范围。如无特殊说明,本发明中所用原料均为市售,例如中药材市场。
实施例1
实施例1提供了一种防脱发植物提取物,按重量份计,所述植物提取物的制备原料包括:干姜10份、红车轴草3份、侧柏叶6份、艾叶2份。
本例还提供了上述防脱发植物提取物的制备方法,包括以下步骤:
(1)干姜与1,3-丙二醇按重量比1:7混合,250W超声提取15分钟,得到超声提取液;
(2)将步骤(1)的超声提取液进行超滤,截留分子量为3000,收集超滤液;
(3)混合除干姜以外的剩余原料,粉碎,过40目筛,得到混合物;
(4)向步骤(3)的混合物中加入混合物6倍重的体积比1:1的1,3-丙二醇和水的混合溶剂,调pH至2.5,65℃下提取2小时,得到提取液;
(5)向步骤(4)的药渣中加入药渣6倍重的体积比1:1的1,3-丙二醇和水的混合溶剂,调pH至7.5,65℃下提取2小时,得到提取液;
(6)合并步骤(4)、(5)的提取液,加入提取液重量2wt%的澄清剂,搅拌均匀后静置1小时,过滤,得到第二滤液;
(7)合并步骤(2)与步骤(6)的滤液,即得防脱发植物提取物。
实施例2
实施例2提供了一种防脱发植物提取物,按重量份计,所述植物提取物的制备原料包括:生姜30份、侧柏叶6份、虎杖4份、獐牙菜6份、黄芪3份。
本例还提供了上述防脱发植物提取物的制备方法,包括以下步骤:
(1)生姜物理压榨,得到汁液;
(2)向步骤(1)的汁液中加入1,3-丙二醇,汁液与1,3-丙二醇的质量比为1:4,搅拌均匀后于4℃环境中冷藏5小时,过滤,得到第一滤液;
(3)将步骤(2)的第一滤液进行超滤,截留分子量为3000,收集超滤液;
(4)混合除生姜以外的剩余原料,粉碎,过40目筛,得到混合物;
(5)向步骤(4)的混合物中加入混合物6倍重的体积比1:1的1,3-丙二醇和水的混合溶剂,调pH至2.5,65℃下提取2小时,得到提取液;
(6)向步骤(5)的药渣中加入药渣6倍重的体积比1:1的1,3-丙二醇和水的混合溶剂,调pH至7.5,65℃下提取2小时,得到提取液;
(7)合并步骤(5)、(6)的提取液,加入提取液重量2wt%的澄清剂,搅拌均匀后静置1小时,过滤,得到第二滤液;
(8)合并步骤(3)与步骤(7)的滤液,即得防脱发植物提取物。
实施例3
实施例3提供了一种防脱发植物提取物,按重量份计,所述植物提取物的制备原料包括:生姜30份、红车轴草3份。
本例还提供了上述防脱发植物提取物的制备方法,包括以下步骤:
(1)生姜物理压榨,得到汁液;
(2)向步骤(1)的汁液中加入丁二醇,汁液与丁二醇的质量比为1:4,搅拌均匀后于4℃环境中冷藏5小时,过滤,得到第一滤液;
(3)将步骤(2)的第一滤液进行超滤,截留分子量为3000,收集超滤液;
(4)红车轴草粉碎,过40目筛;
(5)向步骤(4)的红车轴草中加入药材6倍重的体积比1:1的丁二醇和水的混合溶剂,调pH至2.5,65℃下提取2小时,得到提取液;
(6)向步骤(5)的药渣中加入药渣6倍重的体积比1:1的丁二醇和水的混合溶剂,调pH至7.5,65℃下提取2小时,得到提取液;
(7)合并步骤(5)、(6)的提取液,加入提取液重量2wt%的澄清剂,搅拌均匀后静置1小时,过滤,得到第二滤液;
(8)合并步骤(3)与步骤(7)的滤液,即得防脱发植物提取物。
实施例4
实施例4提供了一种防脱发植物提取物,按重量份计,所述植物提取物的制备原料包括:生姜30份、红车轴草3份、獐牙菜6份、侧柏叶6份、艾叶2份、虎杖4份、黄芪3份。
本例还提供了上述防脱发植物提取物的制备方法,包括以下步骤:
(1)生姜物理压榨,得到汁液;
(2)向步骤(1)的汁液中加入1,3-丙二醇,汁液与1,3-丙二醇的质量比为1:4,搅拌均匀后于4℃环境中冷藏5小时,过滤,得到第一滤液;
(3)将步骤(2)的第一滤液进行超滤,截留分子量为3000,收集超滤液;
(4)混合除生姜以外的剩余原料,粉碎,过40目筛,得到混合物;
(5)向步骤(4)的混合物中加入混合物6倍重的体积比1:1的1,3-丙二醇和水的混合溶剂,调pH至2.5,65℃下提取2小时,得到提取液;
(6)向步骤(5)的药渣中加入药渣6倍重的体积比1:1的1,3-丙二醇和水的混合溶剂,调pH至7.5,65℃下提取2小时,得到提取液;
(7)合并步骤(5)、(6)的提取液,加入提取液重量2wt%的澄清剂,搅拌均匀后静置1小时,过滤,得到第二滤液;
(8)合并步骤(3)与步骤(7)的滤液,即得防脱发植物提取物。
对比例1
对比例1提供了一种防脱发植物提取物,所述植物提取物的制备原料与实施例1相同。
本例还提供了上述防脱发植物提取物的制备方法,与实施例1的区别仅在于,干姜采用加热提取的方式,具体步骤包括:
(1)干姜与1,3-丙二醇按重量比1:7混合,70℃提取2小时,得提取液;
(2)将步骤(1)的提取液进行超滤,截留分子量为3000,收集超滤液;
(3)干姜以外的原料,提取方式同实施例1,提取液与步骤(2)的超滤液合并,即得防脱发植物提取物。
对比例2
对比例2提供了一种防脱发植物提取物,所述植物提取物的制备原料与实施例1相同。
本例还提供了上述防脱发植物提取物的制备方法,与实施例1相比,干姜以外的原料,没有在不同的pH条件下分次提取。包括以下步骤:
(1)用与实施例1相同的方法提取干姜,得超滤液;
(2)混合除干姜以外的剩余原料,粉碎,过40目筛,得到混合物;
(3)向步骤(2)的混合物中加入混合物6倍重的体积比1:1的1,3-丙二醇和水的混合溶剂,65℃下提取2小时,得到提取液;
(4)向步骤(3)的药渣中加入药渣6倍重的体积比1:1的1,3-丙二醇和水的混合溶剂,65℃下提取2小时,得到提取液;
(5)合并步骤(3)、(4)的提取液,加入提取液重量2wt%的澄清剂,搅拌均匀后静置1小时,过滤,得到第二滤液;
(6)合并步骤(5)的第二滤液与步骤(1)的超滤液体,得防脱发植物提取物。
对比例3
对比例3提供了一种防脱发植物提取物,所述植物提取物的制备原料与实施例1相比,将干姜的用量减少至5份,其他原料与实施例1相同。
本例防脱发植物提取物的制备方法与实施例1相同。
性能评价
1.测试本发明实施例1中制得的防脱发植物提取物对毛乳头细胞自噬能力的增强作用。测试结果如图1,图1中细小的斑点为自噬小体。1a为空白对照,看不到自噬小体,仅看到一个椭圆状的细胞核。1b为阳性对照(100μM氯喹),1c、1d分别为0.3wt%、0.1wt%的防脱发植物提取物。1c、1d可观测到大量的自噬小体,说明本发明的防脱发植物提取物可促进毛乳头细胞的自噬。
2.测试本发明实施例1中制得的防脱发植物提取物对毛乳头细胞增殖能力的促进作用,测试结果见图2,其中CK为空白对照,MSCGS(间充质干细胞生长因子)为阳性对照,测试样品包括5μM的米诺地尔(Minoxidil),以及浓度为0.03wt%、0.06wt%、0.12wt%、0.25wt%、0.5wt%、1wt%的防脱发植物提取物。由图2可看出,0.06wt%~0.25wt%的植物提取物对毛乳头细胞增殖有明显的促进作用,略强于5μM的米诺地尔(Minoxidil)。
3.测试本发明实施例1中制得的防脱发植物提取物的控油功效,评价模型为seb-E6E7细胞控油模型,测试结果见图3,图中颜色较深的斑点为脂肪液滴,3a为正常细胞,脂肪滴不明显;3b为模型组细胞,细胞分泌大量的油脂,显示出明显的脂肪液滴;3c和3d分别为1wt%、0.1wt%的植物提取物与模型组细胞共培养24小时后的结果,脂肪液滴明显比模型组少,说明本发明的植物提取物具有良好的控油功效。
4.功效测试:取实施例1-3和对比例1-3制得的植物提取物1份,与0.1份增稠剂、10份水混合制成头皮护理精华液,选取年龄20~50岁的脱发志愿者共60名,将60名志愿者分为6组(每组10人),分别使用实施例1-3和对比例1-3制得的头皮护理精华液。
测试周期共7周,前三周为调理期,使用不含植物提取物的空白头皮护理精华液,后四周为实验期,使用含有植物提取物的头皮护理精华液。使用方法为晚上洗头后涂抹于头皮上,使用频率为两天一次,每次5ml。每次洗头后需收集掉发,通过统计调理期和实验期的掉发数量评估植物提取物的防脱发功效。评价标准分为无效-没有改善、有效-脱发量减少、显效-脱发量明显减少。记录无效、有效、显效的人数,结果见表1。
表1防脱发植物提取物的防脱发效果评价
通过上述测试可以得知,本发明提供了一种防脱发植物提取物,采用特定种类和特定配比的植物原料,并配合恰当的制备方法,使得该提取物能够有效改善脱发,且配方安全无毒,不产生副作用,还具有优异的控油效果。此外,发明人在研究中通过实施例1-4与对比例1-3的对比发现,本发明不仅功效显著还具有优异的稳定性,能够长期保存,进一步提高了其应用价值。
前述的实例仅是说明性的,用于解释本发明所述方法的一些特征。所附的权利要求旨在要求可以设想的尽可能广的范围,且本文所呈现的实施例仅是根据所有可能的实施例的组合的选择的实施方式的说明。因此,申请人的用意是所附的权利要求不被说明本发明的特征的示例的选择限制。在权利要求中所用的一些数值范围也包括了在其之内的子范围,这些范围中的变化也应在可能的情况下解释为被所附的权利要求覆盖。
Claims (10)
1.一种防脱发植物提取物,其特征在于,所述植物提取物的制备原料包括姜、红车轴草、獐牙菜、侧柏叶、艾叶、虎杖、黄芪中的至少两种。
2.如权利要求1所述的防脱发植物提取物,其特征在于,按重量份计,所述植物提取物的制备原料包括:生姜10~50份或干姜4~20份、红车轴草1~10份、獐牙菜3~15份、侧柏叶3~15份、艾叶0.5~5份、虎杖1~10份、黄芪1~5份。
3.如权利要求2所述的防脱发植物提取物,其特征在于,按重量份计,所述植物提取物的制备原料包括:生姜20~40份或干姜6~12份、红车轴草2~5份、獐牙菜5~10份、侧柏叶5~10份、艾叶1~3份、虎杖2~5份、黄芪2~4份。
4.一种如权利要求2或3所述的防脱发植物提取物的制备方法,其特征在于,包括以下步骤:
a.提取生姜或干姜;
b.混合提取除生姜或干姜以外的剩余原料;
c.合并步骤a和步骤b中得到的产物,即得。
5.如权利要求4所述的防脱发植物提取物的制备方法,其特征在于,所述步骤a中,生姜的提取方法包括以下步骤:
a-1.生姜经物理压榨,得到汁液;
a-2.向上述汁液中加入多元醇A,冷藏,过滤,得到第一滤液;
a-3.将上述滤液进行超滤,收集第一超滤液。
干姜的提取方法为:干姜与多元醇A混合,超声提取,提取液进行超滤,收集第二超滤液。
6.如权利要求5所述的防脱发植物提取物的制备方法,其特征在于,所述多元醇A选自乙二醇、丙二醇、1,3-丙二醇、丁二醇、甘油、二丙二醇中的一种或多种的混合。
7.如权利要求4所述的防脱发植物提取物的制备方法,其特征在于,所述步骤b包括:
b-1.混合除生姜或干姜以外的剩余原料,粉碎,过筛,得到混合物;
b-2.向上述混合物中加入体积比(0.5~1.5):1的多元醇B和水的混合溶剂,将pH调至2.0-3.0,提取,收集提取液;
b-3.向b-2的药渣加入体积比(0.5~1.5):1的多元醇B和水的混合溶剂,将pH调至7.5-8.0,提取,收集提取液;
b-4.将b-2和b-3的提取液混合,加入澄清剂,搅拌均匀后静置1小时,过滤,得到第二滤液。
8.如权利要求7所述的防脱发植物提取物的制备方法,其特征在于,所述多元醇B选自乙二醇、丙二醇、1,3-丙二醇、丁二醇、甘油、二丙二醇中的一种或多种的混合。
9.一种如权利要求1~3任一项所述的防脱发植物提取物的应用,其特征在于,其用于头部洗护产品。
10.如权利要求9所述的防脱发植物提取物的应用,其特征在于,其还用于皮肤控油、抑痘产品。
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