CN112004924A - 增强treg细胞抑制特性的方法 - Google Patents
增强treg细胞抑制特性的方法 Download PDFInfo
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- CN112004924A CN112004924A CN201980026673.5A CN201980026673A CN112004924A CN 112004924 A CN112004924 A CN 112004924A CN 201980026673 A CN201980026673 A CN 201980026673A CN 112004924 A CN112004924 A CN 112004924A
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- foxp3
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- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1806331.3A GB201806331D0 (en) | 2018-04-18 | 2018-04-18 | Method |
| GB1806331.3 | 2018-04-18 | ||
| GBGB1806330.5A GB201806330D0 (en) | 2018-04-18 | 2018-04-18 | Engineered regulatory T cell |
| GB1806330.5 | 2018-04-18 | ||
| PCT/GB2019/051098 WO2019202323A1 (en) | 2018-04-18 | 2019-04-17 | Method for enhancing the suppressive properties of treg cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112004924A true CN112004924A (zh) | 2020-11-27 |
Family
ID=66286535
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980026673.5A Pending CN112004924A (zh) | 2018-04-18 | 2019-04-17 | 增强treg细胞抑制特性的方法 |
| CN201980041068.5A Active CN112334571B (zh) | 2018-04-18 | 2019-04-17 | 工程化的调节性t细胞 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980041068.5A Active CN112334571B (zh) | 2018-04-18 | 2019-04-17 | 工程化的调节性t细胞 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US12227756B2 (https=) |
| EP (2) | EP3781673A1 (https=) |
| JP (3) | JP7436383B2 (https=) |
| KR (1) | KR20210003810A (https=) |
| CN (2) | CN112004924A (https=) |
| AU (2) | AU2019254824B2 (https=) |
| CA (2) | CA3105303A1 (https=) |
| GB (3) | GB2611707A (https=) |
| IL (1) | IL278016B2 (https=) |
| SG (1) | SG11202010154UA (https=) |
| WO (2) | WO2019202322A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024174313A1 (zh) * | 2023-02-20 | 2024-08-29 | 苏州大学 | 一种靶向pd1嵌合抗原受体修饰的调节性t细胞及其制备方法与应用 |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7436383B2 (ja) | 2018-04-18 | 2024-02-21 | ユーシーエル ビジネス リミテッド | 操作された調節性t細胞 |
| EP3921427A1 (en) * | 2019-02-05 | 2021-12-15 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Recombinant vectors suitable for the treatment of ipex syndrome |
| GB201915359D0 (en) * | 2019-10-23 | 2019-12-04 | Ucl Business Ltd | Engineered regulatory t cell |
| PL241050B1 (pl) * | 2019-12-12 | 2022-07-25 | Gdanski Univ Medyczny | Zastosowanie limfocytów T regulatorowych jako leku w leczeniu stwardnienia rozsianego |
| AU2021373326A1 (en) * | 2020-11-09 | 2023-06-22 | Quell Therapeutics Ltd | Method for cryopreserving engineered tregs |
| US20220169687A1 (en) | 2020-11-10 | 2022-06-02 | Kyverna Therapeutics, Inc. | Method for treating disease using foxp3+cd4+ t cells |
| WO2022165419A1 (en) | 2021-02-01 | 2022-08-04 | Kyverna Therapeutics, Inc. | Methods for increasing t-cell function |
| AU2022349176A1 (en) * | 2021-09-27 | 2024-04-11 | Kyoto University | Method for producing t cell |
| US20250017967A1 (en) | 2021-12-17 | 2025-01-16 | Quell Therapeutics Limited | Anti-thymocyte globulin for immunomodulation of a subject with regulatory t cells |
| US20230210900A1 (en) * | 2022-01-04 | 2023-07-06 | Kyverna Therapeutics, Inc. | Methods for treating autoimmune diseases |
| EP4496883A1 (en) | 2022-03-22 | 2025-01-29 | Quell Therapeutics Limited | Methods and products for culturing t cells and uses thereof |
| CN119325506A (zh) * | 2022-05-05 | 2025-01-17 | 圭尔医疗有限公司 | 维持调节性t细胞的抑制活性的方法 |
| EP4680728A1 (en) | 2023-03-17 | 2026-01-21 | Quell Therapeutics Limited | Treg therapy |
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| US20090010885A1 (en) * | 2004-07-30 | 2009-01-08 | Vandenbark Arthur A | Methods for Detecting and Treating Autoimmune Disorders |
| CN103212064A (zh) * | 2012-01-19 | 2013-07-24 | 中国科学院上海巴斯德研究所 | 磷酸化途径相关因子在调控调节性t细胞功能中的应用 |
| WO2018001874A1 (en) * | 2016-06-30 | 2018-01-04 | Medizinische Hochschule Hannover | Fusion protein for use in the treatment of hvg disease |
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| US5736137A (en) | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| DK0752248T3 (da) | 1992-11-13 | 2000-11-13 | Idec Pharma Corp | Terapeutisk anvendelse af kimæriske og radioaktivt mærkede antistoffer mod humant B-lymfocytbegrænset differentieringsantig |
| GB9803351D0 (en) | 1998-02-17 | 1998-04-15 | Oxford Biomedica Ltd | Anti-viral vectors |
| EP1105479B1 (en) | 1998-08-11 | 2011-01-12 | Darwin Discovery Limited | Identification of the gene causing the mouse scurfy phenotype and its human ortholog |
| GB0009760D0 (en) | 2000-04-19 | 2000-06-07 | Oxford Biomedica Ltd | Method |
| EP1967525B1 (en) | 2001-05-08 | 2012-11-14 | Darwin Molecular Corporation | A method for regulating immune function in primates using the foxp3 protein |
| FR2825261B1 (fr) | 2001-06-01 | 2003-09-12 | Maco Pharma Sa | Ligne de prelevement du sang placentaire comprenant une poche de rincage |
| JP2007515946A (ja) | 2003-06-13 | 2007-06-21 | オンコマックス アクイジション コーポレイション | 抗腫瘍二元機能融合タンパク質の調製および適用 |
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| EP2126054B1 (en) * | 2007-01-31 | 2016-07-06 | Yeda Research And Development Company Limited | Redirected, genetically-engineered t regulatory cells and their use in suppression of autoimmune and inflammatory disease |
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| JP5626164B2 (ja) | 2011-07-26 | 2014-11-19 | 日本精工株式会社 | ステアリングコラム用支持装置 |
| RU2523058C2 (ru) | 2012-06-29 | 2014-07-20 | Общество с ограниченной ответственностью "Регенекс" | Способ терапии ремиттирующего рассеянного склероза |
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| GB201507368D0 (en) * | 2015-04-30 | 2015-06-17 | Ucl Business Plc | Cell |
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| WO2017062035A1 (en) | 2015-10-09 | 2017-04-13 | Abt Holding Company | Methods for enhancing proliferation of t regulatory cells |
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| JP7436383B2 (ja) | 2018-04-18 | 2024-02-21 | ユーシーエル ビジネス リミテッド | 操作された調節性t細胞 |
| WO2019241549A1 (en) | 2018-06-15 | 2019-12-19 | A2 Biotherapeutics, Inc. | Foxp3-expressing car-t regulatory cells |
| GB201814203D0 (en) | 2018-08-31 | 2018-10-17 | King S College London | Engineered regulatory t cell |
| JP2022533713A (ja) | 2019-05-21 | 2022-07-25 | サンガモ セラピューティクス, インコーポレイテッド | 調節性t細胞における制御された導入遺伝子発現 |
| GB201915359D0 (en) * | 2019-10-23 | 2019-12-04 | Ucl Business Ltd | Engineered regulatory t cell |
| GB201915384D0 (en) | 2019-10-23 | 2019-12-04 | Ucl Business Ltd | Vector |
| GB202007842D0 (en) | 2020-05-26 | 2020-07-08 | Quell Therapeutics Ltd | Polypeptide useful in adoptive cell therapy |
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| WO2024174313A1 (zh) * | 2023-02-20 | 2024-08-29 | 苏州大学 | 一种靶向pd1嵌合抗原受体修饰的调节性t细胞及其制备方法与应用 |
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