CN111991511A - Eye protection cream - Google Patents

Eye protection cream Download PDF

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Publication number
CN111991511A
CN111991511A CN202010916594.6A CN202010916594A CN111991511A CN 111991511 A CN111991511 A CN 111991511A CN 202010916594 A CN202010916594 A CN 202010916594A CN 111991511 A CN111991511 A CN 111991511A
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eye
component
percentage
raw materials
weight
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李海华
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Li Haihua
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Zhejiang Muzhongming Biotechnology Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/898Orchidaceae (Orchid family)
    • A61K36/8984Dendrobium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415Pyridoxine, i.e. Vitamin B6
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482Cassia, e.g. golden shower tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537Salvia (sage)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/56Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/756Phellodendron, e.g. corktree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
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    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents

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Abstract

The invention discloses eye protecting ointment which comprises A, B, C, D, E, F five components. The eye protection cream has the effects of nourishing and moistening eyes, clearing liver and improving eyesight, dispelling wind and resisting inflammation, and promoting blood circulation and removing obstruction in channels, can relieve eye fatigue symptoms such as eye dryness, eye astringency, eye distending pain and the like caused by various eye diseases, and comprehensively care eye health; the eye protection cream disclosed by the invention is convenient to use, does not contain a preservative, is high in applicability, does not cause allergic reaction on any skin, and is mild in use.

Description

Eye protection cream
Technical Field
The invention belongs to the field of health care and medical treatment, and particularly relates to eye protection cream.
Background
With the popularization of various electronic terminals, visual fatigue becomes a topic of public concern more and more, the visual fatigue is a common eye disease, and the specific symptoms are dry eye, acid swelling, visual double image and intermittent visual blurring, which can cause general symptoms such as nausea, vomiting, dizziness, headache, neck muscle tension, shoulder aching pain and the like in severe cases, thereby reducing the working efficiency of adults, causing the learning disorders of teenagers and children, and directly influencing the work and life of people. Mild asthenopia is usually not paid attention by people, so that asthenopia symptoms are aggravated, and various eye diseases can be caused by long-term repeated asthenopia. Modern medicine considers that the occurrence of asthenopia is related to improper use or overstrain of eye muscles, namely that the eyeball is in a search fixation state for a long time, the metabolism of extraocular muscles and ciliary muscles is increased, the accumulation of metabolic waste such as oxygen free radicals is increased, and the cellular structure is damaged and the function is reduced; secondly, the recovery time of macula lutea and retina is prolonged due to the over consumption of cells and the untimely supply of required nutrients, which leads to the aggravation of asthenopia.
Eye protection products on the market are poor in quality at present, a plurality of products contain preservatives, and eye discomfort symptoms are aggravated after the eye protection products are applied, particularly dry eyes and painful eyes.
Disclosure of Invention
The invention aims to provide an eye cream.
In order to achieve the purpose, the invention adopts the following technical scheme:
an eye-protecting ointment, which comprises A, B, C, D, E, F five components.
The component A comprises the following raw materials in percentage by weight:
0-10% of glycerol, 0-5% of sodium polyacrylate grafted starch and 0-1% of hydroxyethyl acrylate/acryloyl dimethyl sodium taurate copolymer. Xanthan gum 0-1%, and water in balance.
The component B comprises the following raw materials in percentage by weight:
0-2% of polydimethylsiloxane, 0-20% of PEG-100 glyceryl stearate, 0-4% of C14-22 alcohol, 0-6% of C12-20 alkyl glucoside, 0-10% of cetearyl alcohol, 0-30% of olive oil, 0-10% of stearic acid, 0-30% of cyclopentadecyl polysiloxane and polydimethylsiloxane cross-linked polymer, 0-4% of p-hydroxyacetophenone, 0-10% of potassium cetyl phosphate, and the balance of petrolatum.
The component C comprises the following raw materials in percentage by weight:
0-50% of ligusticum chuanxiong hort oil and the balance of 1, 2-hexanediol.
The component D comprises the following raw materials in percentage by weight:
0-15% of borneol, 0-15% of propylene glycol and the balance of menthol.
The component E comprises the following raw materials in percentage by weight:
CI 162550-35%, CI 191400-35%, the remainder is caramel color.
The component E comprises the following raw materials in percentage by weight:
0-12% of dendrobium officinale extract, 0-12% of butterflybush flower extract, 0-12% of cassia tora seed extract, 0-12% of phellodendron amurense extract, 0-12% of medlar extract, 0-12% of salvia miltiorrhiza extract, 0-12% of chamomile flower extract and the balance pyridoxine.
The preparation method of the eye cream comprises the following steps:
(1) adding the component A into an emulsifying pot, stirring, heating to 80-85 deg.C, homogenizing for 2-5min at 20-40 Hz;
(2) adding the component B into an emulsifying pot, homogenizing for 4-6min at 30-50Hz, maintaining at 3-5 deg.C for 20-40min, vacuumizing to-0.06-0.08 MPa, and cooling;
(3) cooling to 40-45 deg.C, sequentially adding C, D, F components, and stirring;
(4) adding component E to match colors with the plate, inspecting after color matching, filtering with 200-mesh filter cloth after qualification, and discharging.
The invention has the advantages that:
the eye protection cream has the beneficial effects that the eye protection cream has the effects of nourishing and moistening eyes, clearing liver and improving eyesight, dispelling wind and resisting inflammation, and promoting blood circulation and removing obstruction in channels, can relieve eye fatigue symptoms such as eye dryness, eye astringency and eye distending pain caused by various eye diseases, and comprehensively care eye health;
the eye protection cream disclosed by the invention is convenient to use, does not contain a preservative, is high in applicability, does not cause allergic reaction on any skin, and is mild in use.
Detailed Description
Example 1
An eye-protecting ointment, which comprises A, B, C, D, E, F five components.
The component A comprises the following raw materials in percentage by weight:
10% of glycerol, 5% of sodium polyacrylate grafted starch and 1% of hydroxyethyl acrylate/acryloyl dimethyl sodium taurate copolymer. Xanthan gum 1%, the remainder being water.
The component B comprises the following raw materials in percentage by weight:
2% of polydimethylsiloxane, 20% of PEG-100 glyceryl stearate, 4% of C14-22 alcohol, 6% of C12-20 alkyl glucoside, 10% of cetearyl alcohol, 30% of olive oil, 10% of stearic acid, 30% of cyclopentadecyl dimethicone and dimethicone crosspolymer, 4% of p-hydroxyacetophenone, 10% of potassium cetyl phosphate, and the balance petrolatum.
The component C comprises the following raw materials in percentage by weight:
50% of ligusticum chuanxiong hort oil and 50% of 1, 2-hexanediol.
The component D comprises the following raw materials in percentage by weight:
15% of borneol, 15% of propylene glycol and 70% of menthol.
The component E comprises the following raw materials in percentage by weight:
CI 1625535%, CI 1914035% and caramel color 30%.
The component E comprises the following raw materials in percentage by weight:
12% of dendrobium officinale extract, 12% of butterflybush flower extract, 12% of cassia tora seed extract, 12% of phellodendron amurense extract, 12% of medlar extract, 12% of salvia miltiorrhiza extract, 12% of chamomile extract and the balance pyridoxine.
The preparation method of the eye cream comprises the following steps:
(1) adding the component A into an emulsifying pot, stirring uniformly, heating to 85 deg.C, and homogenizing for 5min at homogenizing frequency of 40 Hz;
(2) adding the component B into an emulsifying pot, homogenizing for 6min at 50Hz, keeping the temperature at 5 deg.C for 40min, and starting to cool under 0.08 MPa;
(3) cooling to 45 ℃, sequentially adding C, D, F components, and uniformly stirring;
(4) adding component E to match colors with the plate, inspecting after color matching, filtering with 200-mesh filter cloth after qualification, and discharging.
Example 2
An eye-protecting ointment, which comprises A, B, C, D, E, F five components.
The component A comprises the following raw materials in percentage by weight:
1% of glycerol, 5% of sodium polyacrylate grafted starch, 1% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 1% of xanthan gum and the balance of water.
The component B comprises the following raw materials in percentage by weight:
1% of polydimethylsiloxane, 1% of PEG-100 glyceryl stearate, 1% of C14-22 alcohol, 1% of C12-20 alkyl glucoside, 1% of cetearyl alcohol, 1% of olive oil, 1% of stearic acid, 1% of cyclopentadecyl dimethicone and dimethicone crosspolymer, 1% of p-hydroxyacetophenone, 1% of potassium cetyl phosphate, and the balance petrolatum.
The component C comprises the following raw materials in percentage by weight:
1% of ligusticum chuanxiong hort oil and 99% of 1, 2-hexanediol.
The component D comprises the following raw materials in percentage by weight:
1% of borneol, 1% of propylene glycol and 98% of menthol.
The component E comprises the following raw materials in percentage by weight:
CI 162551%, CI 191401% and caramel color 98%.
The component E comprises the following raw materials in percentage by weight:
1% of dendrobium officinale extract, 1% of butterflybush flower extract, 1% of cassia tora seed extract, 1% of phellodendron amurense extract, 1% of medlar extract, 1% of salvia miltiorrhiza extract, 1% of chamomile extract and the balance pyridoxine.
The preparation method of the eye cream comprises the following steps:
(1) adding the component A into an emulsifying pot, stirring uniformly, heating to 85 deg.C, and homogenizing for 5min at homogenizing frequency of 40 Hz;
(2) adding the component B into an emulsifying pot, homogenizing for 6min at 50Hz, keeping the temperature at 5 deg.C for 40min, and starting to cool under-0.06 Mpa;
(3) cooling to 45 ℃, sequentially adding C, D, F components, and uniformly stirring;
(4) adding component E to match colors with the plate, inspecting after color matching, filtering with 200-mesh filter cloth after qualification, and discharging.
Example 3
An eye-protecting ointment, which comprises A, B, C, D, E, F five components.
The component A comprises the following raw materials in percentage by weight:
10% of glycerol, 3% of sodium polyacrylate grafted starch and 87% of water.
The component B comprises the following raw materials in percentage by weight:
PEG-100 glyceryl stearate 1%, C14-22 alcohol 4%, C12-20 alkyl glucoside 3%, cetearyl alcohol 2%, olive oil 5%, stearic acid 2%, cyclopentadecyl dimethyl siloxane and dimethicone crosspolymer 3%, p-hydroxyacetophenone 1%, cetyl phosphate potassium 2%, the remainder being petrolatum.
The component C comprises the following raw materials in percentage by weight:
20% of ligusticum chuanxiong hort oil and 80% of 1, 2-hexanediol.
The component D comprises the following raw materials in percentage by weight:
15% of borneol and 85% of menthol.
The component E comprises the following raw materials in percentage by weight:
CI 1914015% and caramel color 85%.
The component E comprises the following raw materials in percentage by weight:
5% of dendrobium officinale extract, 2% of phellodendron amurense extract, 7% of chamomile extract and the balance of pyridoxine.
The preparation method of the eye cream comprises the following steps:
(1) adding the component A into an emulsifying pot, stirring uniformly, heating to 84 ℃, and homogenizing for 4min at the homogenizing frequency of 30 Hz;
(2) adding the component B into an emulsifying pot, homogenizing for 5min at a homogenizing frequency of 40Hz, then keeping the temperature at 4 ℃ for 30min, starting vacuum at 0.07Mpa, and cooling;
(3) cooling to 40 ℃, sequentially adding C, D, F components, and uniformly stirring;
(4) adding component E to match colors with the plate, inspecting after color matching, filtering with 200-mesh filter cloth after qualification, and discharging.
And (3) performance testing:
eye fatigue relief test
200 volunteers were selected and randomly divided into four groups of 50 persons each for eye fatigue relief observation experiments. The eye protection ointments prepared in the first embodiment, the second embodiment and the third embodiment and the commercially available eye protection ointments (Yuguanbaicao eye protection ointments) are respectively used for the volunteers to continuously learn before computers and have symptoms such as eye fatigue and dryness after working for 5 hours.
The experimental results are as follows:
item Dry and astringent condition Has no irritation
Example A product Mitigation Is free of
EXAMPLE two products Mitigation Is free of
EXAMPLE three products Mitigation Is free of
Eye cream on the market Mitigation Slight discomfort

Claims (8)

1. An eye-protecting ointment is characterized by comprising A, B, C, D, E, F five components.
2. The eye-protecting cream of claim 1, wherein the component A comprises the following raw materials in percentage by weight:
0-10% of glycerol, 0-5% of sodium polyacrylate grafted starch, 0-1% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 0-1% of xanthan gum and the balance of water.
3. The eye-protecting cream of claim 1, wherein the component B comprises the following raw materials in percentage by weight:
0-2% of polydimethylsiloxane, 0-20% of PEG-100 glyceryl stearate, 0-4% of C14-22 alcohol, 0-6% of C12-20 alkyl glucoside, 0-10% of cetearyl alcohol, 0-30% of olive oil, 0-10% of stearic acid, 0-30% of cyclopentadecyl polysiloxane and polydimethylsiloxane cross-linked polymer, 0-4% of p-hydroxyacetophenone, 0-10% of potassium cetyl phosphate, and the balance of petrolatum.
4. The eye-protecting cream of claim 1, wherein the component C comprises the following raw materials in percentage by weight:
0-50% of ligusticum chuanxiong hort oil and the balance of 1, 2-hexanediol.
5. The eye-protecting cream of claim 1, wherein the component D comprises the following raw materials in percentage by weight:
0-15% of borneol, 0-15% of propylene glycol and the balance of menthol.
6. The eye-protecting cream of claim 1, wherein the component E comprises the following raw materials in percentage by weight:
CI 162550-35%, CI 191400-35%, the remainder is caramel color.
7. The eye-protecting cream of claim 1, wherein the component E comprises the following raw materials in percentage by weight:
0-12% of dendrobium officinale extract, 0-12% of butterflybush flower extract, 0-12% of cassia tora seed extract, 0-12% of phellodendron amurense extract, 0-12% of medlar extract, 0-12% of salvia miltiorrhiza extract, 0-12% of chamomile flower extract and the balance pyridoxine.
8. The eye cream according to any one of claims 1 to 7, wherein the eye cream is prepared by a method comprising the steps of:
(1) adding the component A into an emulsifying pot, stirring, heating to 80-85 deg.C, homogenizing for 2-5min at 20-40 Hz;
(2) adding the component B into an emulsifying pot, homogenizing for 4-6min at 30-50Hz, maintaining at 3-5 deg.C for 20-40min, vacuumizing to-0.06-0.08 MPa, and cooling;
(3) cooling to 40-45 deg.C, sequentially adding C, D, F components, and stirring;
(4) adding component E to match colors with the plate, inspecting after color matching, filtering with 200-mesh filter cloth after qualification, and discharging.
CN202010916594.6A 2020-09-03 2020-09-03 Eye protection cream Pending CN111991511A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113069373A (en) * 2021-04-06 2021-07-06 邵毅 Dry eye cream, preparation method and application

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CN106728530A (en) * 2017-03-22 2017-05-31 陈顶凯 The preparation method of eye sticker
CN107007529A (en) * 2017-04-19 2017-08-04 陆露梅 A kind of eyeshield cream
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CN107982171A (en) * 2017-12-15 2018-05-04 广东盛美化妆品有限公司 A kind of celestial grass lotion of the Herba Dendrobii extract containing iron sheet and preparation method thereof
CN108853353A (en) * 2018-08-06 2018-11-23 北京朗之星生物科技有限公司 Have effects that protect active compound, preparation method and its application of eyesight
CN109200196A (en) * 2018-11-09 2019-01-15 浙江省医学科学院 Dendrobium stem alkali eye patch and preparation method thereof
CN109498695A (en) * 2019-01-10 2019-03-22 开封御创医学科技有限公司 A kind of small-micelle water extraction Chinese herb medicine eye paste formula and its preparation process
CN109646182A (en) * 2019-02-26 2019-04-19 上海雨桐生物科技有限公司 A kind of Chinese medicine eyeshield hot compress eye-mask and its pack formula

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103285078A (en) * 2013-05-31 2013-09-11 吴克 Comfortable cream
CN103961556A (en) * 2014-04-28 2014-08-06 广西健宝石斛有限责任公司 Dendrobium officinale oculentum for relieving asthenopia
CN107510736A (en) * 2016-06-15 2017-12-26 陕西新视明医药生物科技有限公司 The Chinese medicine composition of eye strain is alleviated in a kind of external application
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