CN111979062A - Nuclear medicine detergent and preparation method thereof - Google Patents
Nuclear medicine detergent and preparation method thereof Download PDFInfo
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- CN111979062A CN111979062A CN201910431833.6A CN201910431833A CN111979062A CN 111979062 A CN111979062 A CN 111979062A CN 201910431833 A CN201910431833 A CN 201910431833A CN 111979062 A CN111979062 A CN 111979062A
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/86—Mixtures of anionic, cationic, and non-ionic compounds
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- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2003—Alcohols; Phenols
- C11D3/2041—Dihydric alcohols
- C11D3/2048—Dihydric alcohols branched
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- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2075—Carboxylic acids-salts thereof
- C11D3/2079—Monocarboxylic acids-salts thereof
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- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
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- C11D3/22—Carbohydrates or derivatives thereof
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- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
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- C11D3/26—Organic compounds containing nitrogen
- C11D3/28—Heterocyclic compounds containing nitrogen in the ring
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- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
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- C11D3/26—Organic compounds containing nitrogen
- C11D3/32—Amides; Substituted amides
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- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/37—Polymers
- C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C11D3/3707—Polyethers, e.g. polyalkyleneoxides
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- C11D3/37—Polymers
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- C11D3/3723—Polyamines or polyalkyleneimines
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- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
- C11D1/12—Sulfonic acids or sulfuric acid esters; Salts thereof
- C11D1/22—Sulfonic acids or sulfuric acid esters; Salts thereof derived from aromatic compounds
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- C11D1/02—Anionic compounds
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- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
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Abstract
The invention provides a nuclear medicine detergent and a preparation method thereof, wherein the nuclear medicine detergent comprises 0.3-1.5 parts by weight of rhamnolipid, 4-8 parts by weight of cationic alkyl polyglycoside, 2-3 parts by weight of dispersant, 0.5-2 parts by weight of corrosion inhibitor, 5-8 parts by weight of solvent, 64.5-85 parts by weight of deionized water and 5-8 parts by weight of hexyl D-glycoside, and the dispersant comprises one or more of methylene dinaphthalene sodium sulfonate, modified polyethyleneimine or sodium lignosulfonate. The nuclear medicine detergent has high decontamination factor, does not interfere with radioactivity measurement and has excellent decontamination effect.
Description
Technical Field
The invention relates to the field of nuclear medicine, in particular to a nuclear medicine detergent and a preparation method thereof.
Background
Nuclear medicine is increasingly used, and no matter clinical diagnosis and laboratory research work, radionuclides are increasingly used. Radionuclide contamination is also inevitable. Such as: containers, vessels, operating tables contaminated during various inspection, treatment and experimental procedures; a radioactive source that evaporates, volatilizes, overflows or spills during operation; synthesizing the radioactive drug, leaching and subpackaging; during the decommissioning period, the upside-down installation and transfer of the source, and the surfaces of the ground, the wall surface, the equipment and the like of the workplace can be polluted by radioactive surfaces with different degrees.
Chinese patent publication No. CN 108560003 discloses a metal surface radioactive contamination detergent, which is a mixture of an oxidizing agent and a complexing agent in equal volumes, wherein the oxidizing agent: 5% C l-1+5％ClO-1An aqueous solution; complexing agent: 5% NaF + 5% KHC2O4Deionized water solution. The product of the invention is only suitable for metal surfaces, and contains Cl < - >, F < - > which can cause corrosion and hydrogen embrittlement to metal substrates during decontamination, and F < - > which can interfere subsequent radiation measurement, so that subsequent waste is not easy to treat.
Chinese invention patent (201210454230.6) discloses a preparation method of radionuclide decontaminant, which comprises a component A and a component B; wherein the component A is konjac glucomannan ester solution; the preparation method of the component B comprises the following steps: organic acid, complexing agent, anionic surfactant, film forming additive, essence and water according to the following ratio: 2 to 5 percent, 5 to 10 percent, 4 to 5 percent and 65 to 80 percent. When in use, the detergent is sprayed on the surface of a material with radioactive pollutants, a film is formed after natural drying for 2 hours, and the film is uncovered to finish the decontamination process.
Until now, in the nuclear medicine field and other laboratories, no special detergent exists, the conventional cleaning agent is basically used for decontamination of radionuclide surface pollution, the decontamination efficiency is very low, and the exposure dose of workers is increased, so that a safe and efficient radionuclide pollution detergent for nuclear medicine is invented.
Disclosure of Invention
The invention aims to provide a nuclear medicine detergent which is safe for a decontamination object, has high decontamination coefficient, does not interfere with radioactivity measurement and can obtain better decontamination effect. The method can effectively remove various nuclides, is safe to parts, containers, surfaces and equipment made of stainless steel, glass, plastics and the like, is not harmful to health, does not contain halogen which can interfere with radioactive measurement, and is used for surfaces polluted by 99Mo, iridium-192, iodine-131 and cobalt-60. Another object of the present invention is to provide a process for producing the above-mentioned detergent. In order to achieve the technical purpose, the invention adopts the specific technical scheme that:
a nuclear medicine detergent comprises the following components in parts by weight:
the dispersant comprises one or more of methylene dinaphthalene sodium sulfonate, modified polyethyleneimine or sodium lignosulfonate.
The improved technical scheme of the invention also comprises 2-5 parts by weight of a defoaming agent, wherein the defoaming agent comprises glycerol polyoxypropylene ether, isooctanol polyoxyethylene polyoxypropylene ether and propylene glycol block polyether, and the cationic alkyl polyglycoside comprises quaternized modified nonionic alkyl glucoside or quaternized modified glucose.
As an improved technical scheme of the invention, the weight ratio of the glycerol polyoxypropylene ether, the isooctanol polyoxyethylene polyoxypropylene ether and the propylene glycol block polyether is 2: 8: 8.
as an improved technical scheme of the invention, the modified polyvinyl alcohol further comprises 3-5 parts by weight of a nonionic surfactant, wherein the nonionic surfactant comprises one or two of branched secondary alcohol polyoxyethylene ether or C9-C11 fatty alcohol polyoxyethylene ether.
As an improved technical scheme of the invention, the corrosion inhibitor comprises benzotriazole and sodium benzoate, wherein the weight ratio of the benzotriazole to the sodium benzoate is 1: 4; the solvent comprises one of 2-methyl-2, 4 pentanediol or N, N-dimethyl decanamide.
A method for preparing the nuclear medicine detergent comprises the following steps:
step S1: providing a reaction kettle, adding 64.5-85 parts by weight of deionized water into the reaction kettle, rotating the reaction kettle at the speed of 600 rpm, and injecting 0.3-1.5 parts by weight of rhamnolipid into the reaction kettle to dissolve for 5 minutes to form a first stock solution;
Step S2: adding 4-8 parts by weight of cationic alkyl polyglycoside, 2-3 parts by weight of dispersant, 3-5 parts by weight of nonionic surfactant, 5-8 parts by weight of hexyl D-glucoside and 2-5 parts by weight of defoamer into the reaction kettle in sequence, and stirring for 30 minutes to form a second stock solution, wherein the dispersant comprises one or more of methylene dinaphthyl sodium sulfonate, modified polyethyleneimine or sodium lignosulfonate;
step S3: heating the reaction kettle to 60 ℃, adding 0.5-2 parts by weight of corrosion inhibitor and 5-8 parts by weight of solvent, and fully stirring.
As an improved technical scheme of the invention, the defoaming agent comprises glycerol polyoxypropylene ether, isooctanol polyoxyethylene polyoxypropylene ether and propylene glycol block polyether, and the cationic alkyl polyglycoside comprises quaternized modified nonionic alkyl glucoside or quaternized modified glucose.
As an improved technical scheme of the invention, the weight ratio of the glycerol polyoxypropylene ether, the isooctanol polyoxyethylene polyoxypropylene ether and the propylene glycol block polyether is 2: 8: 8.
as an improved technical scheme of the invention, the nonionic surfactant comprises one or two of branched secondary alcohol polyoxyethylene ether or C9-11 fatty alcohol polyoxyethylene ether.
As an improved technical scheme of the invention, the corrosion inhibitor comprises benzotriazole and sodium benzoate, wherein the weight ratio of the benzotriazole to the sodium benzoate is 1: 4; the solvent comprises one of 2-methyl-2, 4 pentanediol or N, N-dimethyl decanamide.
Advantageous effects
The dispersant comprises one or more of methylene dinaphthalene sodium sulfonate, modified polyethyleneimine or sodium lignosulfonate, and under the action of the dispersant, the compound surfactant can be better dispersed, the activity of the surfactant is improved, the compound surfactant can quickly permeate into particles in loose pollution and enhance the repulsion between the interior of the pollutant and the surface of a base material, the decontamination effect is enhanced, and the secondary deposition resistance effect is good;
the rhamnolipid can accelerate the degradation of other components, and has the effects of improving surface activity, moistening, spreading and penetrating.
The cationic alkyl polyglycoside comprises quaternized modified nonionic alkyl polyglycoside or quaternized modified glucose, and has a synergistic effect by compounding with C9-C11 narrow-distribution fatty alcohol polyoxyethylene ether or branched secondary alcohol polyoxyethylene.
The hexyl D-glucoside has obvious synergistic effect on the pollution of radionuclides 99Mo, iridium-192, iodine-131 and cobalt-60.
The defoaming agent comprises glycerol polyoxypropylene ether, isooctanol polyoxyethylene polyoxypropylene ether and propylene glycol block polyether, wherein the weight ratio of the glycerol polyoxypropylene ether to the isooctanol polyoxyethylene polyoxypropylene ether to the propylene glycol block polyether is 2: 8: 8. the formula suppresses foams generated by cationic and nonionic surfactants, and reduces the cloud point of the detergent, so that the detergent can greatly improve the cleaning performance of protein and fat dirt at normal temperature without affecting the decontamination of radionuclide.
The solvent comprises one of 2-methyl-2, 4-pentanediol or N, N-dimethyl decanamide, the permeability to the pollutants is enhanced, the speed of the auxiliary agent acting on the pollutants can be increased, the solubilization effect is also achieved, and no solubilizer is required to be added.
The corrosion inhibitor comprises benzotriazole and sodium benzoate, wherein the weight ratio of the benzotriazole to the sodium benzoate is 1: 4, the benzotriazole and sodium benzoate are compounded to be used as a corrosion inhibitor to not corrode ferrous metals and nonferrous metals.
Compared with the existing nuclear medicine detergent, the foam detergent prepared by the invention has the following remarkable characteristics:
1. no halogen which might interfere with the radioactivity measurement, halogen content: F. c l, Br, I, < 20 mg;
2. The device does not contain harmful ions which affect a wastewater treatment system, and is compatible with a wastewater evaporation treatment system and a raffinate storage system;
3. the microbial degradation rate is high, the cleaning agent is a concentrated product, deionized water is adopted for dilution when the cleaning agent is used, the comprehensive decontamination cost is low, and the used raw materials are industrial products;
4. the special complexing component and the surface active component are combined, so that the high efficiency on removing protein, fat, carbon-containing residues, dust, metal particles and organic residues is achieved;
5. the invention has high decontamination factor for surface radionuclide contamination, and is suitable for decontamination of surface contamination such as a working table, an equipment surface, a container, a wall, a ground and the like.
Drawings
FIG. 1 is a flow chart illustrating a process for preparing a nuclear medicine detergent according to an embodiment of the present invention.
Detailed Description
In order to make the purpose and technical solutions of the embodiments of the present invention clearer, the technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. It is to be understood that the embodiments described are only a few embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the described embodiments of the invention without any inventive step, are within the scope of protection of the invention.
It will be understood by those skilled in the art that, unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the prior art and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.
Example 1
A nuclear medicine detergent comprises the following components by weight:
the rhamnolipid can accelerate the degradation of other components, and has the effects of improving surface activity, moistening, spreading and penetrating.
The hexyl D-glucoside has obvious synergistic effect on the pollution of radionuclides 99Mo, iridium-192, iodine-131 and cobalt-60.
The dispersing agent comprises sodium methylene dinaphthalene sulfonate, modified polyethyleneimine and sodium lignin sulfonate.
The nuclear medicine detergent also comprises 20 g of defoaming agent, wherein the defoaming agent comprises glycerol polyoxypropylene ether, isooctanol polyoxyethylene polyoxypropylene ether and propylene glycol block polyether, and the weight ratio of the glycerol polyoxypropylene ether to the isooctanol polyoxyethylene polyoxypropylene ether to the propylene glycol block polyether is 2: 8: 8. the formula suppresses foams generated by cationic and nonionic surfactants, and reduces the cloud point of the detergent, so that the detergent can greatly improve the cleaning performance of protein and fat dirt at normal temperature without affecting the decontamination of radionuclide.
The cationic alkyl polyglycoside is quaternized modified nonionic alkyl glycoside.
The nuclear medicine detergent also comprises 30 g of nonionic surfactant, wherein the nonionic surfactant comprises branched secondary alcohol polyoxyethylene ether and C9-C11 fatty alcohol polyoxyethylene ether.
The corrosion inhibitor comprises benzotriazole and sodium benzoate, wherein the weight ratio of the benzotriazole to the sodium benzoate is 1: 4, the benzotriazole and sodium benzoate are compounded to be used as a corrosion inhibitor to not corrode ferrous metals and nonferrous metals. The solvent is 2-methyl-2, 4 pentanediol, the penetrating capacity of the solvent to the pollutants is enhanced, the speed of the auxiliary agent acting on the pollutants can be increased, the effect of solubilization can be achieved, and no solubilizer is required to be added.
A method for preparing the nuclear medicine detergent comprises the following steps:
step S1: providing a reaction kettle, adding 645 grams of deionized water into the reaction kettle, rotating the reaction kettle at the speed of 600 revolutions per minute, and injecting 3 grams of rhamnolipid into the reaction kettle to dissolve for 5 minutes to form a first stock solution;
step S2: adding 40 g of cationic alkyl polyglycoside, 20 g of dispersing agent, 30 g of nonionic surfactant, 50 g of hexyl D-glucoside and 20 g of defoaming agent into the reaction kettle in sequence, and stirring for 30 minutes to form a second stock solution, wherein the dispersing agent comprises sodium methylene dinaphthalene sulfonate, modified polyethyleneimine and sodium lignosulfonate;
Step S3: the reaction kettle is heated to 60 ℃, 5 g of corrosion inhibitor and 50 g of solvent are added, and the mixture is fully stirred.
The defoaming agent comprises glycerol polyoxypropylene ether, isooctanol polyoxyethylene polyoxypropylene ether and propylene glycol block polyether, wherein the weight ratio of the glycerol polyoxypropylene ether to the isooctanol polyoxyethylene polyoxypropylene ether to the propylene glycol block polyether is 2: 8: 8.
the cationic alkyl polyglycoside is quaternized modified nonionic alkyl glycoside. The nonionic surfactant is branched secondary alcohol polyoxyethylene ether and C9-11 fatty alcohol polyoxyethylene ether. The nonionic alkyl glycoside has synergistic effect with fatty alcohol polyoxyethylene ether with narrow distribution of C9-C11 and branched chain secondary alcohol polyoxyethylene.
The corrosion inhibitor comprises benzotriazole and sodium benzoate, wherein the weight ratio of the benzotriazole to the sodium benzoate is 1: 4; the solvent comprises 2-methyl-2, 4 pentanediol.
Compared with the existing nuclear medicine detergent, the foam detergent prepared by the invention has the following remarkable characteristics:
1. no halogen which might interfere with the radioactivity measurement, halogen content: F. c l, Br, I, < 20 mg;
2. the device does not contain harmful ions which affect a wastewater treatment system, and is compatible with a wastewater evaporation treatment system and a raffinate storage system;
3. The microbial degradation rate is high, the cleaning agent is a concentrated product, deionized water is adopted for dilution when the cleaning agent is used, the comprehensive decontamination cost is low, and the used raw materials are industrial products;
4. the special complexing component and the surface active component are combined, so that the high efficiency on removing protein, fat, carbon-containing residues, dust, metal particles and organic residues is achieved;
5. the invention has high decontamination factor for surface radionuclide contamination, and is suitable for decontamination of surface contamination such as a working table, an equipment surface, a container, a wall, a ground and the like.
Example 2
A nuclear medicine detergent comprises the following components by weight:
the rhamnolipid can accelerate the degradation of other components, and has the effects of improving surface activity, moistening, spreading and penetrating.
The hexyl D-glucoside has obvious synergistic effect on the pollution of radionuclides 99Mo, iridium-192, iodine-131 and cobalt-60.
The dispersant is sodium methylene dinaphthalene sulfonate.
The nuclear medicine detergent also comprises 50 g of defoaming agent, wherein the defoaming agent comprises glycerol polyoxyethylene ether, isooctanol polyoxyethylene polyoxypropylene ether and propylene glycol block polyether, and the weight ratio of the isooctanol polyoxyethylene polyoxypropylene ether to the propylene glycol block polyether is 2: 8: 8. the formula suppresses foams generated by cationic and nonionic surfactants, and reduces the cloud point of the detergent, so that the detergent can greatly improve the cleaning performance of protein and fat dirt at normal temperature without affecting the decontamination of radionuclide.
The cationic alkyl polyglycoside is quaternized modified glucose.
The nuclear medicine detergent also comprises 50 g of nonionic surfactant, and the nonionic surfactant is branched secondary alcohol polyoxyethylene ether.
The corrosion inhibitor comprises benzotriazole and sodium benzoate, wherein the weight ratio of the benzotriazole to the sodium benzoate is 1: 4, the benzotriazole and sodium benzoate are compounded to be used as a corrosion inhibitor to not corrode ferrous metals and nonferrous metals. The solvent is N, N-dimethyl capramide. The solvent has enhanced permeability to pollutants, can improve the action speed of the auxiliary agent on the pollutants, and also plays a role in solubilization without adding a solubilizer.
A method for preparing the nuclear medicine detergent comprises the following steps:
step S1: providing a reaction kettle, adding 850 g of deionized water into the reaction kettle, rotating the reaction kettle at the speed of 600 rpm, and injecting 15 g of rhamnolipid into the reaction kettle to dissolve for 5 minutes to form a first stock solution;
step S2: adding 80 g of cationic alkyl polyglycoside, 30 g of dispersing agent, 50 g of nonionic surfactant, 80 g of hexyl D-glucoside and 50 g of defoaming agent into the reaction kettle in sequence, and stirring for 30 minutes to form a second stock solution, wherein the dispersing agent is sodium methylene dinaphthalene sulfonate;
Step S3: and (3) heating the reaction kettle to 60 ℃, adding 20 g of corrosion inhibitor and 80 g of solvent, and fully stirring.
The defoaming agent comprises glycerol polyoxypropylene ether, isooctanol polyoxyethylene polyoxypropylene ether and propylene glycol block polyether, wherein the weight ratio of the glycerol polyoxypropylene ether to the isooctanol polyoxyethylene polyoxypropylene ether to the propylene glycol block polyether is 2: 8: 8.
the cationic alkyl polyglycoside is quaternized modified glucose, and the nonionic surfactant is branched secondary alcohol polyoxyethylene ether. The quaternization modified glucose and branched secondary alcohol polyoxyethylene are compounded to have a synergistic effect.
The corrosion inhibitor comprises benzotriazole and sodium benzoate, wherein the weight ratio of the benzotriazole to the sodium benzoate is 1: 4; the solvent is N, N-dimethyl capramide.
Compared with the existing nuclear medicine detergent, the foam detergent prepared by the invention has the following remarkable characteristics:
1. no halogen which might interfere with the radioactivity measurement, halogen content: F. c l, Br, I, < 20 mg;
2. the device does not contain harmful ions which affect a wastewater treatment system, and is compatible with a wastewater evaporation treatment system and a raffinate storage system;
3. The microbial degradation rate is high, the cleaning agent is a concentrated product, deionized water is adopted for dilution when the cleaning agent is used, the comprehensive decontamination cost is low, and the used raw materials are industrial products;
4. the special complexing component and the surface active component are combined, so that the high efficiency on removing protein, fat, carbon-containing residues, dust, metal particles and organic residues is achieved;
5. the invention has high decontamination factor for surface radionuclide contamination, and is suitable for decontamination of surface contamination such as a working table, an equipment surface, a container, a wall, a ground and the like.
Example 3
A nuclear medicine detergent comprises the following components by weight:
the rhamnolipid can accelerate the degradation of other components, and has the effects of improving surface activity, moistening, spreading and penetrating.
The hexyl D-glucoside has obvious synergistic effect on the pollution of radionuclides 99Mo, iridium-192, iodine-131 and cobalt-60.
The dispersant comprises modified polyethyleneimine and sodium lignosulfonate.
The nuclear medicine detergent also comprises 30 g of defoaming agent, wherein the defoaming agent comprises glycerol polyoxypropylene ether, isooctanol polyoxyethylene polyoxypropylene ether and propylene glycol block polyether, and the weight ratio of the glycerol polyoxypropylene ether to the isooctanol polyoxyethylene polyoxypropylene ether to the propylene glycol block polyether is 2: 8: 8. the formula suppresses foams generated by cationic and nonionic surfactants, and reduces the cloud point of the detergent, so that the detergent can greatly improve the cleaning performance of protein and fat dirt at normal temperature without affecting the decontamination of radionuclide.
The cationic alkyl polyglycoside is quaternized modified nonionic alkyl glycoside.
The nuclear medicine detergent also comprises 40 g of nonionic surfactant, wherein the nonionic surfactant is C9-C11 fatty alcohol polyoxyethylene ether.
The corrosion inhibitor comprises benzotriazole and sodium benzoate, wherein the weight ratio of the benzotriazole to the sodium benzoate is 1: 4, the compound of benzotriazole and sodium benzoate is used as a corrosion inhibitor to not corrode ferrous metals and nonferrous metals, and the solvent is N, N-dimethyl capramide. The solvent has enhanced permeability to pollutants, can improve the action speed of the auxiliary agent on the pollutants, and can play a role in solubilization without adding a solubilizer.
A method for preparing the nuclear medicine detergent comprises the following steps:
step S1: providing a reaction kettle, adding 700 g of deionized water into the reaction kettle, rotating the reaction kettle at the speed of 600 revolutions per minute, and injecting 12 g of rhamnolipid into the reaction kettle to dissolve for 5 minutes to form a first stock solution;
step S2: sequentially adding 60 g of cationic alkyl polyglycoside, 25 g of dispersing agent, 40 g of nonionic surfactant, 60 g of hexyl D-glucoside and 30 g of defoaming agent into the reaction kettle, and stirring for 30 minutes to form a second stock solution, wherein the dispersing agent is modified polyethyleneimine and sodium lignosulfonate;
Step S3: heating the reaction kettle to 60 ℃, adding 15 g of corrosion inhibitor and 60 g of solvent, and fully stirring.
The defoaming agent comprises glycerol polyoxypropylene ether, isooctanol polyoxyethylene polyoxypropylene ether and propylene glycol block polyether, wherein the weight ratio of the glycerol polyoxypropylene ether to the isooctanol polyoxyethylene polyoxypropylene ether to the propylene glycol block polyether is 2: 8: 8.
the cationic alkyl polyglycoside is quaternized modified nonionic alkyl polyglycoside, the nonionic surfactant is C9-C11 fatty alcohol polyoxyethylene ether, and the quaternized modified nonionic alkyl polyglycoside and the C9-C11 narrowly distributed fatty alcohol polyoxyethylene ether are compounded to have a synergistic effect.
The corrosion inhibitor comprises benzotriazole and sodium benzoate, wherein the weight ratio of the benzotriazole to the sodium benzoate is 1: 4; the solvent comprises N, N-dimethyldecanamide.
Compared with the existing nuclear medicine detergent, the foam detergent prepared by the invention has the following remarkable characteristics:
1. no halogen which might interfere with the radioactivity measurement, halogen content: F. cl, Br, I, < 20 mg;
2. the device does not contain harmful ions which affect a wastewater treatment system, and is compatible with a wastewater evaporation treatment system and a raffinate storage system;
3. The microbial degradation rate is high, the cleaning agent is a concentrated product, deionized water is adopted for dilution when the cleaning agent is used, the comprehensive decontamination cost is low, and the used raw materials are industrial products;
4. the special complexing component and the surface active component are combined, so that the high efficiency on removing protein, fat, carbon-containing residues, dust, metal particles and organic residues is achieved;
5. the invention has high decontamination factor for surface radionuclide contamination, and is suitable for decontamination of surface contamination such as a working table, an equipment surface, a container, a wall, a ground and the like.
Comparative example 1
A nuclear medicine detergent comprises the following components by weight:
the dispersing agent comprises sodium methylene dinaphthalene sulfonate, modified polyethyleneimine and sodium lignin sulfonate.
The nuclear medicine detergent also comprises 20 g of defoaming agent, wherein the defoaming agent comprises glycerol polyoxypropylene ether, isooctanol polyoxyethylene polyoxypropylene ether and propylene glycol block polyether, and the weight ratio of the glycerol polyoxypropylene ether to the isooctanol polyoxyethylene polyoxypropylene ether to the propylene glycol block polyether is 2: 8: 8.
the cationic alkyl polyglycoside is quaternized modified nonionic alkyl glycoside.
The nuclear medicine detergent also comprises 30 g of nonionic surfactant, wherein the nonionic surfactant comprises branched secondary alcohol polyoxyethylene ether and C9-C11 fatty alcohol polyoxyethylene ether.
The corrosion inhibitor comprises benzotriazole and sodium benzoate, wherein the weight ratio of the benzotriazole to the sodium benzoate is 1: 4;
a method for preparing the nuclear medicine detergent comprises the following steps:
step S1: providing a reaction kettle, adding 645 grams of deionized water into the reaction kettle, and rotating the reaction kettle at the speed of 600 revolutions per minute;
step S2: adding 40 g of cationic alkyl polyglycoside, 20 g of dispersant, 30 g of nonionic surfactant and 20 g of defoamer into the reaction kettle in sequence, and stirring for 30 minutes, wherein the dispersant comprises sodium methylene dinaphthalene sulfonate, modified polyethyleneimine and sodium lignosulfonate;
step S3: the reaction kettle is heated to 60 ℃, 5 g of corrosion inhibitor and 50 g of solvent are added, and the mixture is fully stirred.
The defoaming agent comprises glycerol polyoxypropylene ether, isooctanol polyoxyethylene polyoxypropylene ether and propylene glycol block polyether, wherein the weight ratio of the glycerol polyoxypropylene ether to the isooctanol polyoxyethylene polyoxypropylene ether to the propylene glycol block polyether is 2: 8: 8.
the cationic alkyl polyglycoside is quaternized modified nonionic alkyl glycoside. The nonionic surfactant is branched secondary alcohol polyoxyethylene ether and C9-11 fatty alcohol polyoxyethylene ether.
The corrosion inhibitor comprises benzotriazole and sodium benzoate, wherein the weight ratio of the benzotriazole to the sodium benzoate is 1: 4; the solvent comprises 2-methyl-2, 4 pentanediol.
Comparative example 2
A nuclear medicine detergent comprises the following components by weight:
the nuclear medicine detergent also comprises 20 g of defoaming agent, wherein the defoaming agent comprises glycerol polyoxypropylene ether, isooctanol polyoxyethylene polyoxypropylene ether and propylene glycol block polyether, and the weight ratio of the glycerol polyoxypropylene ether to the isooctanol polyoxyethylene polyoxypropylene ether to the propylene glycol block polyether is 2: 8: 8.
the cationic alkyl polyglycoside is quaternized modified nonionic alkyl glycoside.
The nuclear medicine detergent also comprises 30 g of nonionic surfactant, wherein the nonionic surfactant comprises branched secondary alcohol polyoxyethylene ether and C9-C11 fatty alcohol polyoxyethylene ether.
The corrosion inhibitor comprises benzotriazole and sodium benzoate, wherein the weight ratio of the benzotriazole to the sodium benzoate is 1: 4;
a method for preparing the nuclear medicine detergent comprises the following steps:
step S1: providing a reaction kettle, adding 645 grams of deionized water into the reaction kettle, rotating the reaction kettle at the speed of 600 revolutions per minute, and injecting 3 grams of rhamnolipid into the reaction kettle to dissolve for 5 minutes to form a first stock solution;
Step S2: adding 40 g of cationic alkyl polyglycoside, 30 g of nonionic surfactant, 50 g of hexyl D-glucoside and 20 g of defoaming agent into the reaction kettle in sequence, and stirring for 30 minutes to form a second stock solution, wherein the dispersing agent comprises sodium methylene dinaphthalene sulfonate, modified polyethyleneimine and sodium lignosulfonate;
step S3: the reaction kettle is heated to 60 ℃, 5 g of corrosion inhibitor and 50 g of solvent are added, and the mixture is fully stirred.
The defoaming agent comprises glycerol polyoxypropylene ether, isooctanol polyoxyethylene polyoxypropylene ether and propylene glycol block polyether, wherein the weight ratio of the glycerol polyoxypropylene ether to the isooctanol polyoxyethylene polyoxypropylene ether to the propylene glycol block polyether is 2: 8: 8.
the cationic alkyl polyglycoside is quaternized modified nonionic alkyl glycoside. The nonionic surfactant is branched secondary alcohol polyoxyethylene ether and C9-11 fatty alcohol polyoxyethylene ether.
The corrosion inhibitor comprises benzotriazole and sodium benzoate, wherein the weight ratio of the benzotriazole to the sodium benzoate is 1: 4; the solvent comprises 2-methyl-2, 4 pentanediol.
TABLE 1 evaluation of the decontamination Performance of Nuclear medicine detergents on radionuclides in examples and comparative examples
TABLE 2 comparison of physical and chemical Properties of Nuclear medicine detergents in examples and comparative examples
As can be seen from the above tables 1 and 2, the nuclear medicine detergent product of this example has a high decontamination factor and contains no halogen which interferes with the measurement of surface contamination.
The above are merely embodiments of the present invention, which are described in detail and with particularity, and therefore should not be construed as limiting the scope of the invention. It should be noted that, for those skilled in the art, various changes and modifications can be made without departing from the spirit of the present invention, and these changes and modifications are within the scope of the present invention.
Claims (10)
1. The nuclear medicine detergent is characterized by comprising the following components in parts by weight:
the dispersant comprises one or more of methylene dinaphthalene sodium sulfonate, modified polyethyleneimine or sodium lignosulfonate.
2. The nuclear medicine detergent according to claim 1, further comprising 2 to 5 parts by weight of an antifoaming agent, the antifoaming agent comprising glycerol polyoxypropylene ether, isooctanol polyoxyethylene polyoxypropylene ether and propylene glycol block polyether, and the cationic alkylpolyglycoside comprising quaternized modified nonionic alkyl glycoside or quaternized modified glucose.
3. The nuclear medicine detergent according to claim 2, wherein the weight ratio of the glycerol polyoxypropylene ether, the isooctanol polyoxyethylene polyoxypropylene ether and the propylene glycol block polyether is 2: 8: 8.
4. the nuclear medicine detergent of claim 1, further comprising 3 to 5 parts by weight of a nonionic surfactant, wherein the nonionic surfactant comprises one or both of branched secondary alcohol polyoxyethylene ether or C9-C11 fatty alcohol polyoxyethylene ether.
5. The nuclear medicine detergent according to claim 1, wherein the corrosion inhibitor comprises benzotriazole and sodium benzoate, and the weight ratio of the benzotriazole to the sodium benzoate is 1: 4; the solvent comprises one of 2-methyl-2, 4 pentanediol or N, N-dimethyl decanamide.
6. A method for preparing the nuclear medicine detergent as claimed in any one of claims 1 to 5, comprising the steps of:
step S1: providing a reaction kettle, adding 64.5-85 parts by weight of deionized water into the reaction kettle, rotating the reaction kettle at the speed of 600 rpm, and injecting 0.3-1.5 parts by weight of rhamnolipid into the reaction kettle to dissolve for 5 minutes to form a first stock solution;
Step S2: adding 4-8 parts by weight of cationic alkyl polyglycoside, 2-3 parts by weight of dispersant, 3-5 parts by weight of nonionic surfactant, 5-8 parts by weight of hexyl D-glucoside and 2-5 parts by weight of defoamer into the reaction kettle in sequence, and stirring for 30 minutes to form a second stock solution, wherein the dispersant comprises one or more of methylene dinaphthyl sodium sulfonate, modified polyethyleneimine or sodium lignosulfonate;
step S3: heating the reaction kettle to 60 ℃, adding 0.5-2 parts by weight of corrosion inhibitor and 5-8 parts by weight of solvent, and fully stirring.
7. The method of claim 6, wherein the antifoaming agent comprises glycerol polyoxypropylene ether, isooctanol polyoxyethylene polyoxypropylene ether, and propylene glycol block polyether, and wherein the cationic alkylpolyglycoside comprises a quaternized modified nonionic alkyl glycoside or quaternized modified glucose.
8. The method of claim 7, wherein the weight ratio of said glycerol polyoxypropylene ether, said isooctanol polyoxyethylene polyoxypropylene ether, and said propylene glycol block polyether is 2: 8: 8.
9. the method of claim 6, wherein the nonionic surfactant comprises one or both of a branched secondary alcohol polyoxyethylene ether or a C9-11 fatty alcohol polyoxyethylene ether.
10. The method according to claim 6, characterized in that the corrosion inhibitor comprises benzotriazole and sodium benzoate, and the weight ratio of the benzotriazole to the sodium benzoate is 1: 4; the solvent comprises one of 2-methyl-2, 4 pentanediol or N, N-dimethyl decanamide.
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