CN111973694A - Preparation method of pinellia ternate dew film coated tablets - Google Patents

Preparation method of pinellia ternate dew film coated tablets Download PDF

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Publication number
CN111973694A
CN111973694A CN202010758675.8A CN202010758675A CN111973694A CN 111973694 A CN111973694 A CN 111973694A CN 202010758675 A CN202010758675 A CN 202010758675A CN 111973694 A CN111973694 A CN 111973694A
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China
Prior art keywords
pinellia ternate
pinellia
coated tablets
steps
following
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CN202010758675.8A
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Chinese (zh)
Inventor
黄锁义
陈石梅
黄与路
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Youjiang Medical University for Nationalities
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Youjiang Medical University for Nationalities
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Priority to CN202010758675.8A priority Critical patent/CN111973694A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888—Pinellia
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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Abstract

The invention discloses a preparation method of pinellia ternate dew film coated tablets, which comprises the following steps of weighing raw materials according to the following formula, extracting liquid medicine, mixing, concentrating to obtain extract, and drying to obtain pinellia ternate dew dry extract powder; adding oleum Menthae Dementholatum, starch, soybean carbohydrate gum, konjac gum and phlorizin into the dried powder of the pinellia ternata syrup, mixing, adding magnesium stearate, mixing, and tabletting to obtain tablet of pinellia ternata syrup; adding sodium carboxymethylcellulose, polyethylene glycol, polyvinyl alcohol, beta-cyclodextrin, a plasticizer and a colorant into a high-speed dispersion machine to prepare a coating solution; and (3) placing the pinellia ternata essence tablets and the coating solution into a coating machine for spray coating, and drying to obtain the pinellia ternata essence film coated tablets. The pinellia ternate dew film coated tablet provided by the invention has the advantages of moisture resistance, light resistance, taste masking, low water absorption rate and the like, is not easy to generate splinters, spots and mildew, improves the stability of the medicine, prolongs the storage period and masks the medicine taste; the adhesive has good processing fluidity, is not easy to bond, and improves the production efficiency.

Description

Preparation method of pinellia ternate dew film coated tablets
Technical Field
The invention relates to the technical field of Chinese patent medicine preparations, in particular to a preparation method of a pinellia ternate dew film coated tablet.
Background
The pinellia ternate dew preparation is a traditional Chinese medicine preparation prepared from raw pinellia ternate, loquat leaves, polygala tenuifolia (soaked), flos farfarae, platycodon grandiflorum, ephedra, liquorice, dried orange peel and peppermint oil, and is sold in the market. The pharmacological action is as follows: has effects of clearing lung-heat, relieving cough, regulating stomach function, lowering adverse qi, and quenching thirst, and can be used for treating cough due to lung heat, asthma, emesis due to stomach heat, phlegm eliminating, and cough and asthma; polygala tenuifolia has the actions of expelling phlegm and arresting cough, and can prevent vomiting or wind-cold and cough with profuse sputum.
The pinellia ternate syrup preparation sold in the market at present is mainly pinellia ternate syrup granules, and according to market sales, patient feedback and finished product sample retention inspection conditions, the pinellia ternate syrup granules contain volatile components of peppermint oil, so that volatile oil can slowly seep out in the storage process, the appearance of a finished product is changed, even mildew occurs, and many patients dare not to use the pinellia ternate syrup preparation with worry. The granules are easy to be wetted, mildewed and deteriorated during the storage process, thereby influencing the exertion of the drug effect and directly influencing the treatment effect. The pinellia ternate dew granules have a heavy traditional Chinese medicine taste and cannot be accepted by some consumers.
The film coating agent is usually composed of a film forming agent, a plasticizer, an adhesive and the like, is coated on the surface of a solid preparation in a spraying mode to form a film with a certain thickness, can be used for coating solid pharmaceutical preparations, food processing, candies and crop seeds, plays a role in improving the taste, protecting moisture resistance, improving the stability of products and brightening eyes, and becomes a new technology for replacing sugar coatings. At present, the method has been applied to the field of medicine. The preparation of the film-coated tablet commonly used at present has the defects of high viscosity, easy adhesion, low production efficiency, high water absorption rate and the like.
The above background disclosure is only for the purpose of assisting understanding of the inventive concept and technical solutions of the present invention, and does not necessarily belong to the prior art of the present patent application, and should not be used for evaluating the novelty and inventive step of the present application in the case that there is no clear evidence that the above content is disclosed at the filing date of the present patent application.
Disclosure of Invention
The invention provides a preparation method of pinellia ternate syrup film coated tablets, aiming at the defects of the existing pinellia ternate syrup granules. The pinellia ternate dew film coated tablet provided by the invention has the advantages of moisture resistance, light resistance, taste masking, low water absorption rate and the like, is not easy to generate splinters, spots and mildew, improves the stability of the medicine, prolongs the storage period and masks the medicine taste; the adhesive has good processing fluidity, is not easy to bond, and improves the production efficiency.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
a preparation method of pinellia ternate dew film coated tablets comprises the following steps:
(1) weighing the raw materials according to the following formula: 79.2g of unprocessed pinellia tuber, 79.2g of loquat leaf, 50.7g of polygala root (soaked), 47.4g of common coltsfoot flower, 31.5g of platycodon root, 31.5g of ephedra, 31.5g of liquorice, 47.4g of tangerine peel and 3ml of peppermint oil;
(2) moistening rhizoma Pinelliae, decocting with 5-7 times of water for 2 hr twice, filtering, concentrating the filtrate to relative density of 1.05-1.10, cooling, adding 95% ethanol, precipitating for 24 hr, collecting supernatant, and recovering ethanol to obtain rhizoma Pinelliae liquid medicine; adding 90% ethanol 3-5 times the weight of pericarpium Citri Tangerinae, soaking for 24 hr, percolating at a speed of 3-5 ml/min, and recovering ethanol to obtain pericarpium Citri Tangerinae solution; decocting folium Eriobotryae, radix Polygalae (soaking), flos Farfarae, radix Platycodi, herba Ephedrae and Glycyrrhrizae radix with water, filtering, standing, and mixing filtrates; mixing the filtrate with the above crude rhizoma Pinelliae liquid medicine and pericarpium Citri Tangerinae liquid medicine, concentrating to obtain soft extract, and drying to obtain dried powder of rhizoma Pinelliae syrup;
(3) adding peppermint oil, starch, soybean carbohydrate gum, konjac glucomannan and phlorizin into the pinellia ternate syrup dry extract powder, uniformly mixing, wherein the mass ratio of the pinellia ternate syrup dry extract powder to the starch to the soybean carbohydrate gum to the konjac gum to the phlorizin is 100: 150: 200:30-50:10-20:3-5, adding magnesium stearate accounting for 1-3% of the mass of the pinellia ternate syrup dry extract powder, uniformly mixing, and tabletting to obtain pinellia ternate syrup tablets;
(4) adding 5-10 parts of sodium carboxymethylcellulose, 10-15 parts of polyethylene glycol, 3-5 parts of polyvinyl alcohol, 0.5-1.5 parts of beta-cyclodextrin, 1-3 parts of plasticizer and 10-15 parts of colorant into a high-speed dispersion machine, adding warm water, and stirring at high speed to prepare a coating solution with the mass concentration of 20-25%;
(5) putting the pinellia ternata essence tablets and the coating solution into a coating machine, wherein the spraying speed of the coating is 100-.
Further, the water decoction in the step (2) is carried out for 2-3 times by adding 6-8 times of water, and each time of decoction is carried out for 2-3 h.
Further, the concentration in the step (2) is concentrated to thick paste with the relative density of 1.10-1.15 under the pressure of-0.05 to-0.10 Mpa and the temperature of 60 to 80 ℃.
Further, the plasticizer is composed of sucrose glycerin fatty acid ester, lauric acid monoglyceride and rhamnolipid.
Further, the mass ratio of the sucrose glycerin fatty acid ester, the lauric acid monoglyceride and the rhamnolipid in the plasticization is 3-5:3-5: 1-3.
Further, the colorant is one or a combination of titanium dioxide, talcum powder and lake.
Further, the high-speed stirring in the step (4) is performed at a rotation speed of 500-.
Further, the drying in the step (2) and the step (5) is drying by using a pulse airflow dryer.
Further, the pulse airflow drying is drying at the temperature of 60-80 ℃ and the air speed of 10-15 m/s.
Compared with the prior art, the invention has the advantages and beneficial effects that:
1. the pinellia ternate dew film coated tablet provided by the invention has the advantages of moisture resistance, light resistance, taste masking, low water absorption rate and the like, is not easy to generate splinters, spots and mildew, improves the stability of the medicine, prolongs the storage period and masks the medicine taste; the adhesive has good processing fluidity, is not easy to bond, and improves the production efficiency.
2. According to the method, starch, soybean glue and konjac glucomannan are added in the preparation of the plain tablets, so that the bonding performance of a system is improved, the tabletting rate is improved, phlorizin with the effect of reducing 'three high' is added to replace common sucrose, and the method is more suitable for patients with 'three high'.
3. According to the method, sodium carboxymethylcellulose, polyethylene glycol, polyvinyl alcohol and beta-cyclodextrin are used as film forming agents, so that a good film forming effect is achieved; the sucrose glycerin fatty acid ester, the lauric acid monoglyceride and the rhamnolipid are used as the plasticizer, so that the viscosity of a system can be reduced, the processing fluidity is improved, the production efficiency is improved, the defects of adhesion of a tablet core, damage of a coating film and improvement of the production effect in the coating process in the prior art are overcome, the coating material can be better encapsulated on the surface of the medicinal material, the surface of the prepared coating film is smooth, and the coating appearance is smooth and flat.
4. The method utilizes the pulse airflow dryer to dry the semi-summer dew dry paste powder and the coated tablets, is uniformly heated, has short drying time and improved efficiency, and is beneficial to the dispersion of a medium in the drying process.
Detailed Description
The present invention will be described in further detail with reference to specific embodiments. It should be emphasized that the following description is merely exemplary in nature and is not intended to limit the scope of the invention or its application.
Example 1
A preparation method of pinellia ternate dew film coated tablets comprises the following steps:
(1) weighing the raw materials according to the following formula: 79.2g of unprocessed pinellia tuber, 79.2g of loquat leaf, 50.7g of polygala root (soaked), 47.4g of common coltsfoot flower, 31.5g of platycodon root, 31.5g of ephedra, 31.5g of liquorice, 47.4g of tangerine peel and 3ml of peppermint oil;
(2) moistening rhizoma Pinelliae, decocting with 6 times of water for 2 hr twice, filtering, concentrating the filtrate to relative density of 1.05, cooling, adding 95% ethanol, precipitating for 24 hr, collecting supernatant, and recovering ethanol to obtain rhizoma Pinelliae liquid medicine; adding 90% ethanol 4.5 times the weight of pericarpium Citri Tangerinae, soaking for 24 hr, percolating at 4ml per minute, and recovering ethanol to obtain pericarpium Citri Tangerinae solution; decocting six medicines of folium Eriobotryae, radix Polygalae (soaking), flos Farfarae, radix Platycodi, herba Ephedrae and Glycyrrhrizae radix with 6 times of water for 3 times, each time for 2.5 hr, filtering, standing, and mixing filtrates; mixing the filtrate with the above crude rhizoma Pinelliae liquid medicine and pericarpium Citri Tangerinae liquid medicine, concentrating at 65 deg.C under-0.08 Mpa to relative density of 1.10 to obtain soft extract, and drying with pulsed airflow dryer at 70 deg.C and wind speed of 15m/s to obtain dried powder of rhizoma Pinelliae Preparatum;
(3) adding peppermint oil, starch, soybean carbohydrate gum, konjac glucomannan and phlorizin into the pinellia ternate syrup dry extract powder, uniformly mixing, adding magnesium stearate with the mass of 2.0% of the pinellia ternate syrup dry extract powder, uniformly mixing, and tabletting to obtain pinellia ternate syrup tablets, wherein the mass ratio of the pinellia ternate syrup dry extract powder to the starch to the soybean carbohydrate gum to the konjac gum to the phlorizin is 100:180:45:12: 4;
(4) adding 7 parts of sodium carboxymethylcellulose, 15 parts of polyethylene glycol, 4 parts of polyvinyl alcohol, 1.2 parts of beta cyclodextrin, 2.5 parts of plasticizer and 13 parts of titanium dioxide colorant into a high-speed dispersion machine, wherein the plasticizer consists of sucrose glycerin fatty acid ester, lauric acid monoglyceride and rhamnolipid in a mass ratio of 4:3:3, adding 50 ℃ warm water, and stirring at a high speed of 500r/min for 20min to prepare a coating solution with a mass concentration of 23%;
(5) placing the pinellia ternata essence tablet and the coating solution in a coating machine, wherein the spraying speed of the coating is 150ml/min, taking out the coated tablet, and drying by using a pulse airflow dryer at the temperature of 60 ℃ and the air speed of 15m/s to obtain the pinellia ternata essence film coated tablet.
Example 2
A preparation method of pinellia ternate dew film coated tablets comprises the following steps:
(1) weighing the raw materials according to the following formula: 79.2g of unprocessed pinellia tuber, 79.2g of loquat leaf, 50.7g of polygala root (soaked), 47.4g of common coltsfoot flower, 31.5g of platycodon root, 31.5g of ephedra, 31.5g of liquorice, 47.4g of tangerine peel and 3ml of peppermint oil;
(2) moistening rhizoma Pinelliae, decocting with 7 times of water for two times (each for 2 hr), filtering, concentrating the filtrate to relative density of 1.10, cooling, adding 95% ethanol, precipitating for 24 hr, collecting supernatant, and recovering ethanol to obtain rhizoma Pinelliae liquid medicine; adding 90% ethanol with weight 3.5 times of that of pericarpium Citri Tangerinae, soaking for 24 hr, percolating at speed of 3ml per minute, and recovering ethanol to obtain pericarpium Citri Tangerinae solution; decocting six medicines of folium Eriobotryae, radix Polygalae (soaking), flos Farfarae, radix Platycodi, herba Ephedrae and Glycyrrhrizae radix with 7 times of water for 2 times, each time for 3 hr, filtering, standing, and mixing filtrates; mixing the filtrate with the above crude rhizoma Pinelliae liquid medicine and pericarpium Citri Tangerinae liquid medicine, concentrating at vacuum degree of-0.06 Mpa and temperature of 75 deg.C to relative density of 1.05 to obtain soft extract, and drying with pulse airflow dryer at temperature of 65 deg.C and wind speed of 15m/s to obtain dried powder of rhizoma Pinelliae Preparatum;
(3) adding peppermint oil, starch, soybean carbohydrate gum, konjac glucomannan and phlorizin into the pinellia ternate syrup dry extract powder, uniformly mixing, adding magnesium stearate accounting for 2.5% of the pinellia ternate syrup dry extract powder by mass, uniformly mixing, and tabletting to obtain pinellia ternate syrup tablets;
(4) adding 8 parts of sodium carboxymethylcellulose, 12 parts of polyethylene glycol, 5 parts of polyvinyl alcohol, 1.0 part of beta cyclodextrin, 2.7 parts of plasticizer and 15 parts of titanium dioxide colorant into a high-speed dispersion machine, wherein the plasticizer consists of sucrose glycerin fatty acid ester, lauric acid monoglyceride and rhamnolipid in a mass ratio of 3:4:2, adding 50 ℃ warm water, and stirring at a high speed of 800r/min for 30min to prepare a coating solution with a mass concentration of 21%;
(5) placing the pinellia ternata essence tablet and the coating solution in a coating machine, wherein the spraying speed of the coating is 120ml/min, taking out the coated tablet, and drying by using a pulse airflow dryer at the temperature of 70 ℃ and the air speed of 12m/s to obtain the pinellia ternata essence film coated tablet.
Example 3
A preparation method of pinellia ternate dew film coated tablets comprises the following steps:
(1) weighing the raw materials according to the following formula: 79.2g of unprocessed pinellia tuber, 79.2g of loquat leaf, 50.7g of polygala root (soaked), 47.4g of common coltsfoot flower, 31.5g of platycodon root, 31.5g of ephedra, 31.5g of liquorice, 47.4g of tangerine peel and 3ml of peppermint oil;
(2) moistening rhizoma Pinelliae, decocting with 6 times of water for 2 hr twice, filtering, concentrating the filtrate to relative density of 1.10, cooling, adding 95% ethanol, precipitating for 24 hr, collecting supernatant, and recovering ethanol to obtain rhizoma Pinelliae liquid medicine; adding 90% ethanol 5 times the weight of pericarpium Citri Tangerinae, soaking for 24 hr, percolating at 5ml per minute, and recovering ethanol to obtain pericarpium Citri Tangerinae solution; decocting six medicines of folium Eriobotryae, radix Polygalae (soaking), flos Farfarae, radix Platycodi, herba Ephedrae and Glycyrrhrizae radix with 8 times of water for 2 times, each time for 2.5 hr, filtering, standing, and mixing filtrates; mixing the filtrate with the above crude rhizoma Pinelliae liquid medicine and pericarpium Citri Tangerinae liquid medicine, concentrating at vacuum degree of-0.10 Mpa and temperature of 60 deg.C to relative density of 1.10 to obtain soft extract, and drying with pulse airflow dryer at temperature of 80 deg.C and wind speed of 10m/s to obtain dried powder of rhizoma Pinelliae Preparatum;
(3) adding peppermint oil, starch, soybean carbohydrate gum, konjac glucomannan and phlorizin into the pinellia ternate syrup dry extract powder, uniformly mixing, adding magnesium stearate with the mass of 1.5% of the pinellia ternate syrup dry extract powder, uniformly mixing, and tabletting to obtain pinellia ternate syrup tablets, wherein the mass ratio of the pinellia ternate syrup dry extract powder to the starch to the soybean carbohydrate gum to the konjac gum to the phlorizin is 100:160:50:18: 5;
(4) adding 10 parts of sodium carboxymethylcellulose, 13 parts of polyethylene glycol, 3 parts of polyvinyl alcohol, 1.5 parts of beta cyclodextrin, 1.8 parts of plasticizer and 12 parts of titanium dioxide colorant into a high-speed dispersion machine, wherein the plasticizer consists of sucrose glycerin fatty acid ester, lauric acid monoglyceride and rhamnolipid in a mass ratio of 5:4:3, adding 50 ℃ warm water, and stirring at a high speed of 1000r/min for 15min to prepare a coating solution with the mass concentration of 24%;
(5) placing the pinellia ternata essence tablet and the coating solution in a coating machine, wherein the spraying speed of the coating is 100ml/min, taking out the coated tablet, and drying by using a pulse airflow dryer at the temperature of 80 ℃ and the air speed of 15m/s to obtain the pinellia ternata essence film coated tablet.
Example 4
A preparation method of pinellia ternate dew film coated tablets comprises the following steps:
(1) weighing the raw materials according to the following formula: 79.2g of unprocessed pinellia tuber, 79.2g of loquat leaf, 50.7g of polygala root (soaked), 47.4g of common coltsfoot flower, 31.5g of platycodon root, 31.5g of ephedra, 31.5g of liquorice, 47.4g of tangerine peel and 3ml of peppermint oil;
(2) moistening rhizoma Pinelliae, decocting with 7 times of water for two times (each for 2 hr), filtering, concentrating the filtrate to relative density of 1.10, cooling, adding 95% ethanol, precipitating for 24 hr, collecting supernatant, and recovering ethanol to obtain rhizoma Pinelliae liquid medicine; adding 90% ethanol 4 times the weight of pericarpium Citri Tangerinae, soaking for 24 hr, percolating at a speed of 3ml per minute, and recovering ethanol to obtain pericarpium Citri Tangerinae solution; decocting six medicines of folium Eriobotryae, radix Polygalae (soaking), flos Farfarae, radix Platycodi, herba Ephedrae and Glycyrrhrizae radix with 6 times of water for 3 times, each time for 2 hr, filtering, standing, and mixing filtrates; mixing the filtrate with the above crude rhizoma Pinelliae liquid medicine and pericarpium Citri Tangerinae liquid medicine, concentrating at 65 deg.C under-0.07 Mpa to relative density of 1.05 to obtain soft extract, and drying with pulsed airflow dryer at 70 deg.C and wind speed of 15m/s to obtain dried powder of rhizoma Pinelliae Preparatum;
(3) adding peppermint oil, starch, soybean carbohydrate gum, konjac glucomannan and phlorizin into the pinellia ternate syrup dry extract powder, uniformly mixing, adding magnesium stearate with the mass of 1.5% of the pinellia ternate syrup dry extract powder, uniformly mixing, and tabletting to obtain pinellia ternate syrup tablets, wherein the mass ratio of the pinellia ternate syrup dry extract powder to the starch to the soybean carbohydrate gum to the konjac gum to the phlorizin is 100:175:42:15: 3.5;
(4) adding 6 parts of sodium carboxymethylcellulose, 10 parts of polyethylene glycol, 5 parts of polyvinyl alcohol, 1.0 part of beta cyclodextrin, 2.4 parts of plasticizer and 10 parts of titanium dioxide colorant into a high-speed dispersion machine, wherein the plasticizer consists of sucrose glycerin fatty acid ester, lauric acid monoglyceride and rhamnolipid in a mass ratio of 3:4:1, adding 60 ℃ warm water, and stirring at a high speed of 500r/min for 30min to prepare a coating solution with a mass concentration of 22%;
(5) placing the pinellia ternata essence tablet and the coating solution in a coating machine, wherein the spraying speed of the coating is 100ml/min, taking out the coated tablet, and drying by using a pulse airflow dryer at the temperature of 70 ℃ and the air speed of 15m/s to obtain the pinellia ternata essence film coated tablet.
The appearances of the coated tablets of pinellia ternate dew film and the tablets of pinellia ternate dew element prepared in the examples 1 to 4 were observed, and the coated tablets and the tablets were placed in an environment of 50 ℃ and RH75% to count the water absorption, the mildew rate and the breakage rate for 1 month and 3 months, respectively, and the statistical results are shown in Table 1.
Table 1: the invention provides a performance test result of pinellia ternate dew film coated tablets
Figure 866126DEST_PATH_IMAGE001
From the test results, the pinellia ternate dew film coated tablets prepared by the method have the advantages of obviously reduced water absorption, obviously improved mildew rate and breakage rate and excellent storage performance compared with the tablets without coating treatment.
The foregoing is a more detailed description of the invention in connection with specific/preferred embodiments and is not intended to limit the practice of the invention to those descriptions. It will be apparent to those skilled in the art that various substitutions and modifications can be made to the described embodiments without departing from the spirit of the invention, and such substitutions and modifications are to be considered as within the scope of the invention.

Claims (9)

1. A preparation method of pinellia ternate dew film coated tablets is characterized by comprising the following steps: the method comprises the following steps:
(1) weighing the raw materials according to the following formula: 79.2g of unprocessed pinellia tuber, 79.2g of loquat leaf, 50.7g of polygala root (soaked), 47.4g of common coltsfoot flower, 31.5g of platycodon root, 31.5g of ephedra, 31.5g of liquorice, 47.4g of tangerine peel and 3ml of peppermint oil;
(2) moistening rhizoma Pinelliae, decocting with 5-7 times of water for 2 hr twice, filtering, concentrating the filtrate to relative density of 1.05-1.10, cooling, adding 95% ethanol, precipitating for 24 hr, collecting supernatant, and recovering ethanol to obtain rhizoma Pinelliae liquid medicine; adding 90% ethanol 3-5 times the weight of pericarpium Citri Tangerinae, soaking for 24 hr, percolating at a speed of 3-5 ml/min, and recovering ethanol to obtain pericarpium Citri Tangerinae solution; decocting folium Eriobotryae, radix Polygalae (soaking), flos Farfarae, radix Platycodi, herba Ephedrae and Glycyrrhrizae radix with water, filtering, standing, and mixing filtrates; mixing the filtrate with the above crude rhizoma Pinelliae liquid medicine and pericarpium Citri Tangerinae liquid medicine, concentrating to obtain soft extract, and drying to obtain dried powder of rhizoma Pinelliae syrup;
(3) adding peppermint oil, starch, soybean carbohydrate gum, konjac glucomannan and phlorizin into the pinellia ternate syrup dry extract powder, uniformly mixing, wherein the mass ratio of the pinellia ternate syrup dry extract powder to the starch to the soybean carbohydrate gum to the konjac gum to the phlorizin is 100: 150: 200:30-50:10-20:3-5, adding magnesium stearate accounting for 1-3% of the mass of the pinellia ternate syrup dry extract powder, uniformly mixing, and tabletting to obtain pinellia ternate syrup tablets;
(4) adding 5-10 parts of sodium carboxymethylcellulose, 10-15 parts of polyethylene glycol, 3-5 parts of polyvinyl alcohol, 0.5-1.5 parts of beta-cyclodextrin, 1-3 parts of plasticizer and 10-15 parts of colorant into a high-speed dispersion machine, adding warm water, and stirring at high speed to prepare a coating solution with the mass concentration of 20-25%;
(5) putting the pinellia ternata essence tablets and the coating solution into a coating machine, wherein the spraying speed of the coating is 100-.
2. The preparation method of the pinellia ternate dew film-coated tablet according to claim 1, which is characterized by comprising the following steps of: the water decoction in the step (2) is to add 6-8 times of water for 2-3 times, and each time for 2-3 hours.
3. The method for preparing pinellia ternate dew film-coated tablets according to claim 1, wherein the method comprises the following steps: the concentration in the step (2) is concentrated to thick paste with the relative density of 1.10-1.15 under the pressure of-0.05 to-0.10 Mpa and the temperature of 60 to 80 ℃.
4. The method for preparing pinellia ternate dew film-coated tablets according to claim 1, wherein the method comprises the following steps: the plasticizer is composed of sucrose glycerin fatty acid ester, lauric acid monoglyceride and rhamnolipid.
5. The method for preparing pinellia ternate dew film-coated tablets according to claim 4, wherein the method comprises the following steps: the mass ratio of the sucrose glycerin fatty acid ester, the lauric acid monoglyceride and the rhamnolipid in the plasticization is 3-5:3-5: 1-3.
6. The method for preparing pinellia ternate dew film-coated tablets according to claim 1, wherein the method comprises the following steps: the colorant is one or a combination of titanium dioxide, talcum powder and lake.
7. The method for preparing pinellia ternate dew film-coated tablets according to claim 1, wherein the method comprises the following steps: the high-speed stirring in the step (4) is performed for 10-30min at the rotating speed of 500-1000 r/min.
8. The method for preparing pinellia ternate dew film-coated tablets according to claim 1, wherein the method comprises the following steps: and (5) drying in the step (2) and the step (5) by adopting a pulse airflow dryer.
9. The method for preparing pinellia ternate dew film-coated tablets according to claim 8, wherein the method comprises the following steps: and (3) drying by the pulse airflow in the steps (2) and (5) at the temperature of 60-80 ℃ and the wind speed of 10-15 m/s.
CN202010758675.8A 2020-07-31 2020-07-31 Preparation method of pinellia ternate dew film coated tablets Pending CN111973694A (en)

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