CN111973674A - Ointment for treating diabetic foot ulcer and preparation method thereof - Google Patents
Ointment for treating diabetic foot ulcer and preparation method thereof Download PDFInfo
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- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The invention discloses an ointment for treating diabetic foot ulcer and a preparation method thereof, belonging to the field of ointments, and the ointment for treating diabetic foot ulcer comprises the following materials in parts by weight: 95-105 parts of medical light liquid paraffin, 20-23 parts of natural medicinal beeswax, 0.3-0.5 part of polyhexamethylene biguanide and 0.1-0.3 part of borneol. The ointment for treating diabetic foot ulcer and the preparation method thereof have the advantages that the curative effect is obvious, the medicinal components are pure, the pain of a patient in the treatment process is small, the cure rate is high, the preparation method is simple, the market prospect is wide, the polyhexamethylene guanidine has extremely strong capability of killing bacteria, is broad-spectrum and efficient, has long-term antibacterial effect and no corrosiveness, does not contain harmful substances such as iodine, chlorine, aldehyde and the like, and the ointment is matched with the sophora flavescens extract, the cortex dictamni extract and the cortex phellodendri extract, so that the ointment has good effects of clearing heat, purging fire, detoxifying, removing stasis, promoting diuresis, relieving swelling, detoxifying, promoting granulation and eliminating.
Description
Technical Field
The invention relates to the technical field of ointment, in particular to an ointment for treating diabetic foot ulcer and a preparation method thereof.
Background
The diabetic foot ulcer belongs to the categories of blood impediment, gangrene and the like in traditional Chinese medicine. "surgical orthodox" cloud: the patient suffering from gangrene also experiences black rot … … as well as the other patient suffering from gangrene occurs in the hands and feet and in the bones and muscles. Its etiology is complex, and it is often associated with cold, trauma and toxic heat. Diabetic patients with hyperglycemia, glucose toxicity, long-term accumulation of blood, fire transformation due to long stagnation, yin fluid burn, healthy qi loss, qi deficiency, blood pushing, blood weakness, blood stasis and vein obstruction due to long-term increase of yin blood viscosity, no blood supply to extremities, and skin and muscle breakage due to damp-heat soaking to form gangrene.
Diabetic patients can cause the damage and the malformation of soft tissues and bone joint systems of feet due to the combination of peripheral neuropathy and peripheral vascular diseases with overhigh mechanical pressure, thereby causing a series of foot problems from mild neurological symptoms to severe ulcers, infections, vascular diseases, Charcot joint diseases and neuropathic fractures, and if the active treatment cannot fully solve the symptoms and complications of lower limbs, the problems can cause
The existing ointment for treating diabetic foot ulcer has the defect of inaccurate curative effect in different degrees, once the regeneration treatment is incomplete or other complications are caused, amputation surgical methods are still adopted, so that more pain is brought to patients, and the curative effect is not clear.
Disclosure of Invention
Technical problem to be solved
1. Technical problem to be solved
Aiming at the problems in the prior art, the invention aims to provide the ointment for treating the diabetic foot ulcer and the preparation method thereof, which have the advantages of high use and cure rate, solve the defect that the existing ointment for treating the diabetic foot ulcer has not definite curative effect in different degrees, and still adopt a surgical method of amputation once the treatment is not comprehensive or other complications are caused, so that the problems of great pain to patients and unclear cure effect are brought.
(II) technical scheme
In order to achieve the purpose, the invention provides the following technical scheme: an ointment for treating diabetic foot ulcer comprises the following materials in parts by weight: 95-105 parts of medical light liquid paraffin, 20-23 parts of natural medicinal beeswax, 0.3-0.5 part of polyhexamethylene biguanide and 0.1-0.3 part of borneol.
Preferably, the medicine also comprises 5-10 parts of sophora flavescens extract, 5-10 parts of cortex dictamni extract and 5-10 parts of phellodendron extract according to the weight part ratio.
Preferably, the ointment for treating diabetic foot ulcer comprises the following materials in parts by weight: 95 parts of medical light liquid paraffin, 20 parts of natural medicinal beeswax, 0.3 part of polyhexamethylene biguanide, 0.1 part of borneol, 5 parts of radix sophorae flavescentis extract, 5 parts of cortex dictamni extract and 5 parts of cortex phellodendri extract.
Preferably, the ointment for treating diabetic foot ulcer comprises the following materials in parts by weight: 100 parts of medical light liquid paraffin, 21 parts of natural medicinal beeswax, 0.4 part of polyhexamethylene biguanide, 0.2 part of borneol, 7.5 parts of radix sophorae flavescentis extract, 7.5 parts of cortex dictamni extract and 7.5 parts of cortex phellodendri extract.
Preferably, the ointment for treating diabetic foot ulcer comprises the following materials in parts by weight: 105 parts of medical light liquid paraffin, 23 parts of natural medicinal beeswax, 0.5 part of polyhexamethylene biguanide, 0.3 part of borneol, 10 parts of radix sophorae flavescentis extract, 10 parts of cortex dictamni extract and 10 parts of cortex phellodendri extract.
Another technical problem to be solved by the invention is to provide a preparation method of an ointment for treating diabetic foot ulcer, which comprises the following steps:
1) placing medical light liquid paraffin into a heating container, heating to the temperature of 100-120 ℃, adding natural beeswax, continuously stirring until the natural beeswax is completely melted, and removing the flame after melting to obtain a mixture A for later use;
2) when the mixture A obtained in the step 1) is cooled to 50 ℃, sequentially adding polyhexamethylene biguanide and borneol powder, and fully and uniformly stirring to obtain a mixture B for later use;
3) sequentially adding the sophora flavescens extract, the cortex dictamni extract and the cortex phellodendri extract into a container, uniformly mixing and stirring, adding into the mixture B obtained in the step 2), fully and uniformly stirring, and cooling into a paste to obtain a paste C for later use;
4) Sealing the paste C obtained in the step 4) in a sterilized container to obtain the ointment for treating the diabetic foot ulcer.
(III) advantageous effects
Compared with the prior art, the invention provides the ointment for treating diabetic foot ulcer and the preparation method thereof, and the ointment has the following beneficial effects:
1. the ointment for treating diabetic foot ulcer and the preparation method thereof have the advantages of obvious treatment effect, pure medicinal components, little pain in the treatment process of patients, high cure rate, simple preparation method and wide market prospect.
2. The ointment for treating diabetic foot ulcer and the preparation method thereof have the advantages that medical light liquid paraffin is used as the matrix of the ointment, polyhexamethylene guanidine has extremely strong capability of killing bacteria, is broad-spectrum and efficient, has long-term bacteriostatic action, is non-corrosive, does not contain harmful substances such as iodine, chlorine, aldehyde and the like, and has good effects of clearing heat, purging fire, detoxifying, removing blood stasis, promoting diuresis, relieving swelling, detoxifying, promoting granulation and eliminating malignant sores by matching with the lightyellow sophora root extract, the cortex dictamni extract and the golden cypress extract.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The first embodiment is as follows:
an ointment for treating diabetic foot ulcer comprises the following materials in parts by weight: 95 parts of medical light liquid paraffin, 20 parts of natural medicinal beeswax, 0.3 part of polyhexamethylene biguanide, 0.1 part of borneol, 5 parts of radix sophorae flavescentis extract, 5 parts of cortex dictamni extract and 5 parts of cortex phellodendri extract.
A preparation method of an ointment for treating diabetic foot ulcer comprises the following steps:
1) putting medical light liquid paraffin into a heating container, heating to 100 ℃, adding natural beeswax, continuously stirring until the natural beeswax is completely melted, and removing the fire after melting to obtain a mixture A for later use;
2) when the mixture A obtained in the step 1) is cooled to 50 ℃, sequentially adding polyhexamethylene biguanide and borneol powder, and fully and uniformly stirring to obtain a mixture B for later use;
3) Sequentially adding the sophora flavescens extract, the cortex dictamni extract and the cortex phellodendri extract into a container, uniformly mixing and stirring, adding into the mixture B obtained in the step 2), fully and uniformly stirring, and cooling into a paste to obtain a paste C for later use;
4) sealing the paste C obtained in the step 4) in a sterilized container to obtain the ointment for treating the diabetic foot ulcer.
Example two:
an ointment for treating diabetic foot ulcer comprises the following materials in parts by weight: 100 parts of medical light liquid paraffin, 21 parts of natural medicinal beeswax, 0.4 part of polyhexamethylene biguanide, 0.2 part of borneol, 7.5 parts of radix sophorae flavescentis extract, 7.5 parts of cortex dictamni extract and 7.5 parts of cortex phellodendri extract.
A preparation method of an ointment for treating diabetic foot ulcer comprises the following steps:
1) putting medical light liquid paraffin into a heating container, heating to 110 ℃, adding natural beeswax, continuously stirring until the natural beeswax is completely melted, and removing the fire after melting to obtain a mixture A for later use;
2) when the mixture A obtained in the step 1) is cooled to 50 ℃, sequentially adding polyhexamethylene biguanide and borneol powder, and fully and uniformly stirring to obtain a mixture B for later use;
3) Sequentially adding the sophora flavescens extract, the cortex dictamni extract and the cortex phellodendri extract into a container, uniformly mixing and stirring, adding into the mixture B obtained in the step 2), fully and uniformly stirring, and cooling into a paste to obtain a paste C for later use;
4) sealing the paste C obtained in the step 4) in a sterilized container to obtain the ointment for treating the diabetic foot ulcer.
Example three:
an ointment for treating diabetic foot ulcer comprises the following materials in parts by weight: 105 parts of medical light liquid paraffin, 23 parts of natural medicinal beeswax, 0.5 part of polyhexamethylene biguanide, 0.3 part of borneol, 10 parts of radix sophorae flavescentis extract, 10 parts of cortex dictamni extract and 10 parts of cortex phellodendri extract.
A preparation method of an ointment for treating diabetic foot ulcer comprises the following steps:
1) heating medical light liquid paraffin to 120 deg.C, adding natural medicinal Cera flava, stirring, melting, and removing fire to obtain mixture A;
2) when the mixture A obtained in the step 1) is cooled to 50 ℃, sequentially adding polyhexamethylene biguanide and borneol powder, and fully and uniformly stirring to obtain a mixture B for later use;
3) Sequentially adding the sophora flavescens extract, the cortex dictamni extract and the cortex phellodendri extract into a container, uniformly mixing and stirring, adding into the mixture B obtained in the step 2), fully and uniformly stirring, and cooling into a paste to obtain a paste C for later use;
4) sealing the paste C obtained in the step 4) in a sterilized container to obtain the ointment for treating the diabetic foot ulcer.
In the above formula, the light liquid paraffin is mainly composed of a mixture of multiple liquid hydrocarbons prepared from petroleum, and can be used as base material for ointment and liniment.
The curative effect standard is as follows: according to the clinical research guidelines for treating acute ulcer with new Chinese medicines of Ministry of health, the method can be divided into: firstly, clinical cure, local swelling disappears, the skin color is normal, and the ulcer surface is completely healed. ② the medicine has obvious effect-local swelling and obvious improvement of skin color, and the ulcer surface is reduced by more than 70%. Thirdly, the swelling and the skin color are obviously improved, and the ulcer surface is reduced by more than 30 percent. Fourthly, the product is invalid, namely the product cannot reach the valid standard.
Experimental example: randomly extracting 60 patients, randomly dividing into two groups of 30 patients, wherein the treatment group adopts external application of ointment prepared in any one of the first to third embodiments on the basis of basic treatment, and the control group adopts external application of ointment sold in a certain market on the basis of basic treatment, wherein the treatment group comprises 14 male patients and 16 female patients, and the age is between 44 and 76 years old; control group 13 male patients and 17 female patients aged between 43 and 72 years, the results are given in the following table:
| Treatment groups and results | Cure (example) | Obvious effect (example) | Effective (example) | Invalid (example) | Cure rate (%) | Rate of recovery (%) |
| Treatment group | 26 | 2 | 1 | 1 | 86.67 | 93.33 |
| Control group | 15 | 5 | 8 | 2 | 50 | 66.67 |
The experimental result shows that the cure rate of the ointment for treating diabetic foot ulcer prepared by the method in the scheme is up to more than 85%, the cure rate is up to more than 90%, and the effect is obvious compared with certain commercially available ointment.
In summary, the following steps: the ointment for treating diabetic foot ulcer and the preparation method thereof provided by the invention have the advantages of obvious treatment effect, pure medicinal components, small pain in the treatment process of patients, high cure rate, simple preparation method and wide market prospect.
The foregoing is only a preferred embodiment of the present invention; the scope of the invention is not limited thereto. Any person skilled in the art should be able to cover the technical scope of the present invention by equivalent or modified solutions and modifications within the technical scope of the present invention.
Claims (6)
1. An ointment for treating diabetic foot ulcer, which is characterized in that: the material comprises the following materials in parts by weight: 95-105 parts of medical light liquid paraffin, 20-23 parts of natural medicinal beeswax, 0.3-0.5 part of polyhexamethylene biguanide and 0.1-0.3 part of borneol.
2. The ointment for treating diabetic foot ulcer according to claim 1, characterized in that: the medicine also comprises 5-10 parts of sophora flavescens extracts, 5-10 parts of cortex dictamni extracts and 5-10 parts of phellodendron extracts according to the weight part ratio.
3. An ointment for the treatment of diabetic foot ulcers according to claim 1 or 2, characterized in that: the material comprises the following materials in parts by weight: 95 parts of medical light liquid paraffin, 20 parts of natural medicinal beeswax, 0.3 part of polyhexamethylene biguanide, 0.1 part of borneol, 5 parts of radix sophorae flavescentis extract, 5 parts of cortex dictamni extract and 5 parts of cortex phellodendri extract.
4. An ointment for the treatment of diabetic foot ulcers according to claim 1 or 2, characterized in that: the material comprises the following materials in parts by weight: 100 parts of medical light liquid paraffin, 21 parts of natural medicinal beeswax, 0.4 part of polyhexamethylene biguanide, 0.2 part of borneol, 7.5 parts of radix sophorae flavescentis extract, 7.5 parts of cortex dictamni extract and 7.5 parts of cortex phellodendri extract.
5. An ointment for the treatment of diabetic foot ulcers according to claim 1 or 2, characterized in that: the material comprises the following materials in parts by weight: 105 parts of medical light liquid paraffin, 23 parts of natural medicinal beeswax, 0.5 part of polyhexamethylene biguanide, 0.3 part of borneol, 10 parts of radix sophorae flavescentis extract, 10 parts of cortex dictamni extract and 10 parts of cortex phellodendri extract.
6. A preparation method of an ointment for treating diabetic foot ulcer is characterized by comprising the following steps:
1) placing medical light liquid paraffin into a heating container, heating to the temperature of 100-120 ℃, adding natural medicinal beeswax, stirring until the mixture is completely melted, and removing the fire after the mixture is melted to obtain a mixture A for later use;
2) when the mixture A obtained in the step 1) is cooled to 50 ℃, sequentially adding polyhexamethylene biguanide and borneol powder, and fully and uniformly stirring to obtain a mixture B for later use;
3) sequentially adding the sophora flavescens extract, the cortex dictamni extract and the cortex phellodendri extract into a container, uniformly mixing and stirring, adding into the mixture B obtained in the step 2), fully and uniformly stirring, and cooling into a paste to obtain a paste C for later use;
4) sealing the paste C obtained in the step 4) in a sterilized container to obtain the ointment for treating the diabetic foot ulcer.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910437888.8A CN111973674A (en) | 2019-05-24 | 2019-05-24 | Ointment for treating diabetic foot ulcer and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910437888.8A CN111973674A (en) | 2019-05-24 | 2019-05-24 | Ointment for treating diabetic foot ulcer and preparation method thereof |
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Citations (5)
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| CN101987152A (en) * | 2010-08-24 | 2011-03-23 | 赵建勇 | Ointment for treating diabetes foot ulcer |
| CN105796897A (en) * | 2016-04-11 | 2016-07-27 | 孔庆来 | Pharmaceutical composition for treating diabetic feet |
| CN105902660A (en) * | 2016-06-15 | 2016-08-31 | 张光昇 | Pharmaceutical composition for treating bedsores, diabetic feet and eczema |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101987152A (en) * | 2010-08-24 | 2011-03-23 | 赵建勇 | Ointment for treating diabetes foot ulcer |
| CN105796897A (en) * | 2016-04-11 | 2016-07-27 | 孔庆来 | Pharmaceutical composition for treating diabetic feet |
| CN105902660A (en) * | 2016-06-15 | 2016-08-31 | 张光昇 | Pharmaceutical composition for treating bedsores, diabetic feet and eczema |
| CN105920163A (en) * | 2016-06-21 | 2016-09-07 | 任华 | External traditional Chinese medicine composition, preparation method thereof and application |
| CN107753951A (en) * | 2017-07-19 | 2018-03-06 | 青岛海芬健康产业科技有限公司 | A kind of foot-bath liquor of the treatment diabetes containing Pudilan |
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| 李澎，等: "生肌膏治疗糖尿病足的临床观察", 《中国临床康复》 * |
| 李澎等: "生肌膏治疗糖尿病足临床观察及分析", 《辽宁中医学院学报》 * |
| 洪国平: "冰片蜂蜜纱条治疗难愈创口35例", 《光明中医》 * |
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Application publication date: 20201124 |