CN116549538A - Compound medicine for treating high-temperature burns and scalds and preparation method thereof - Google Patents
Compound medicine for treating high-temperature burns and scalds and preparation method thereof Download PDFInfo
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- CN116549538A CN116549538A CN202310734127.5A CN202310734127A CN116549538A CN 116549538 A CN116549538 A CN 116549538A CN 202310734127 A CN202310734127 A CN 202310734127A CN 116549538 A CN116549538 A CN 116549538A
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- 206010053615 Thermal burn Diseases 0.000 title claims abstract description 59
- 239000003814 drug Substances 0.000 title claims abstract description 56
- 150000001875 compounds Chemical class 0.000 title claims abstract description 42
- 238000002360 preparation method Methods 0.000 title abstract description 15
- 238000010438 heat treatment Methods 0.000 claims abstract description 32
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 27
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000009910 sargent gloryvine Substances 0.000 claims abstract description 18
- 244000048199 Hibiscus mutabilis Species 0.000 claims abstract description 17
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 238000000034 method Methods 0.000 claims abstract description 13
- 239000002994 raw material Substances 0.000 claims abstract description 13
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- 238000001914 filtration Methods 0.000 claims abstract description 12
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- 240000004980 Rheum officinale Species 0.000 claims abstract description 11
- 235000008081 Rheum officinale Nutrition 0.000 claims abstract description 11
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims abstract description 8
- 235000011187 glycerol Nutrition 0.000 claims abstract description 8
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims abstract description 8
- 235000010234 sodium benzoate Nutrition 0.000 claims abstract description 8
- 239000004299 sodium benzoate Substances 0.000 claims abstract description 8
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- 239000004334 sorbic acid Substances 0.000 claims abstract description 8
- 229940075582 sorbic acid Drugs 0.000 claims abstract description 8
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims description 24
- 229940116229 borneol Drugs 0.000 claims description 24
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- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims description 24
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The invention discloses a high-temperature burn and scald compound medicine and a preparation method thereof, wherein the high-temperature burn and scald compound medicine comprises the following raw materials in parts by mass: 40-60 parts of sargent gloryvine, 15-25 parts of cotton rose hibiscus leaf, 40-60 parts of rheum officinale and 15-25 parts of radix ampelopsis; the preparation method comprises the following steps: adding caulis Sargentodoxae, folium Hibisci Mutabilis, radix Rumicis and radix Ampelopsis into water or oleum Sesami, heating to boil, and decocting with slow fire; filtering, adding Borneolum Syntheticum into the filtrate, heating to melt Borneolum Syntheticum, adding sodium benzoate, sorbic acid, and glycerol, and stirring; or filtering, adding Cera flava into the filtrate, melting, adding Borneolum Syntheticum, and stirring. The invention discloses a method for treating burns and scalds by using the sargent gloryvine, which is an original innovation, and the sargent gloryvine, the Hibiscus sabdariffa leaf, the rheum officinale and the Japanese ampelopsis are mixed and decocted to obtain the medicament for treating burns and scalds, which has the remarkable effects of few medicament raw materials, good treatment effect and short treatment time, has no toxic or side effect and has no pain in the treatment process.
Description
Technical Field
The invention belongs to the technical field of production of burn or scald medicines, and particularly relates to a high-temperature burn and scald compound medicine and a preparation method thereof.
Background
High temperature burns and scalds are serious skin and muscle tissue injuries, are common accidental injuries in life, such as burns and scalds of hot oil, flame, boiling water, hot vapor and the like, and are one of clinical sudden diseases. After the human body is thermally damaged by various reasons, different pathological changes can be generated in various periods of attack, wound repair and change of skin, subcutaneous tissues and organs of the whole body. If the change of the wound surface after burn is carried out, the waste heat of the wound surface after burn continuously damages skin tissues, the wound surface is deepened continuously, cell necrosis is quickened, the superficial wound surface with red swelling and heat pain starts to form blisters, the wound surface with the skin falling off forms extravasation liquid, and the chronic heat injury can be prolonged to 24 hours or even 72 hours. Intravascular tissue changes: after the capillary vessel is thermally damaged, vascular endothelial cells are triggered to fall off, microcirculation embolism is formed, inflammatory edema is formed on the wound surface and the periphery of the wound surface, a large amount of body fluid leakage is caused by unsmooth blood backflow, the wound surface forms blisters, and body fluid at the skin damage position is extravasated.
The degree of burn and scald is generally divided into three degrees: i degree scald: the skin is only injured, the injured skin is red and swollen, and feels hot and spicy and painful, but no blister appears; degree II burn and scald: injury to dermis, local redness and swelling, fever, and pain, and obvious blisters; deep II degree: burns are severe burns, and heal very slowly and leave considerable scars behind. Skin in burn area is shrunken and deformed, which affects functions; degree III burn and scald: full-thickness skin, including the underlying fat, bones and muscles, is damaged and is gray or reddish brown. If the infection is caused by improper treatment, the optimal treatment time of burns and scalds is delayed, the burns and scalds are difficult to heal for a long time, permanent skin pigmentation, scars and even disability are formed.
Although the traditional medicine for treating high-temperature burns and scalds can produce a certain curative effect, the traditional medicine has the advantages of multiple medicine components, complex preparation, slow detumescence, pain relieving and granulation promoting effects and long healing time.
Disclosure of Invention
The invention aims to solve the problems and provide the high-temperature burn and scald compound medicine with good treatment effect and short cure time and the preparation method thereof.
The invention realizes the above purpose through the following technical scheme:
a compound medicine for treating high-temperature burns and scalds comprises the following raw materials in parts by mass: 40-60 parts of sargent gloryvine, 15-25 parts of cotton rose hibiscus leaf, 40-60 parts of rheum emodi, and 15-25 parts of Japanese ampelopsis.
The sargent gloryvine is also called small and mild in head or fine She Gonggen, mild in nature and bitter in taste, has the effects of astringing to stop bleeding, promoting qi and blood circulation, relieving swelling and pain and the like, and can be used for stopping bleeding of trauma, conditioning dysmenorrhea and the like; hong Zhu Teng is commonly used for stopping bleeding, but is not used for burns and scalds in the prior art.
The folium Hibisci Mutabilis is leaf of Hibiscus Mutabilis of Malvaceae, and has effects of cooling blood, removing toxic substances, relieving swelling and pain.
Rumex madaio is root of Rumex madaio of Rumex of Polygonaceae, and has effects of clearing heat and toxic substances, cooling blood, stopping bleeding, removing blood stasis, relieving swelling, relaxing bowels, and killing parasite.
Ampelopsis japonica is woody vine of Ampelopsis genus of Vitaceae family, and has effects of clearing heat, detoxicating, detumescence and relieving pain.
Preferably, in order to further improve the drug effect, the mass parts of the raw materials are: 50 parts of sargent gloryvine, 20 parts of cotton rose hibiscus leaf, 50 parts of rheum emodi and 20 parts of ampelopsis japonica.
Specifically, the Gao Wenshao scalding compound medicine is a spray and further comprises the following raw materials in parts by mass: 0.4-0.6 part of borneol, 0.08-0.12 part of sodium benzoate, 0.15-0.25 part of sorbic acid, 2.5-3.5 parts of glycerin and 300-400 parts of water.
Or the Gao Wenshao scald compound medicine is ointment and also comprises the following raw materials in parts by mass: 0.4-0.6 part of borneol, 4-6 parts of beeswax and 250-350 parts of sesame oil.
The invention also discloses a preparation method of the high-temperature burn and scald compound medicine, which comprises the following steps:
adding 40-60 parts of sargent gloryvine, 15-25 parts of cotton rose hibiscus leaf, 40-60 parts of rheum emodi and 15-25 parts of Japanese ampelopsis into 600-800 parts of water, heating to boil, and decocting with small fire for 1.5-2.5 hours;
step two, decocting and concentrating until 300-400 parts of water is left, filtering, adding 0.4-0.6 part of borneol into the filtrate, and heating to melt the borneol;
and thirdly, after the borneol is completely melted, stopping heating, adding 0.08-0.12 part of sodium benzoate, 0.15-0.25 part of sorbic acid and 2.5-3.5 parts of glycerin, and uniformly stirring to obtain the high-temperature burn and scald compound medicine in a spray form.
The invention also discloses a preparation method of the compound medicine for treating high-temperature burns and scalds, which comprises the following steps:
step 1, adding 40-60 parts of sargent gloryvine, 15-25 parts of cotton rose leaves, 40-60 parts of rheum officinale and 15-25 parts of radix ampelopsis into 500-700 parts of sesame oil, heating to boil, and decocting with small fire for 1-2 hours;
step 2, decocting and concentrating until 250-350 parts of sesame oil remains, filtering, adding 4-6 parts of beeswax into the filtrate, and heating to melt the beeswax;
and 3, stopping heating after the beeswax is completely melted, adding 0.4-0.6 part of borneol, stirring uniformly to obtain the ointment-type high-temperature burn and scald compound medicine, and placing the ointment-type high-temperature burn and scald compound medicine in an environment below 0 ℃ for more than 20 hours for use.
The invention has the beneficial effects that:
the invention relates to a method for treating burns and scalds by using the red thorn vine, which is an original innovation, and the red thorn vine is mixed with the cotton rose leaves, the rheum officinale and the Japanese ampelopsis and decocted to obtain the medicine for treating burns and scalds, which has the remarkable effects of few medicine raw materials, good treatment effect and short healing time, can cure various high-temperature burns and scalds, chronic erosion ulcer wounds and bedsores, can be directly sprayed, applied or applied to affected parts during treatment, can be used for moist exposure, semi-exposure or wrapping treatment, is convenient to use, has no toxic or side effect, and has no pain in the treatment process.
Detailed Description
The invention is further illustrated by the following examples:
example 1:
a preparation method of a spray-type high-temperature burn and scald compound medicine comprises the following steps:
adding 50 parts of sargent gloryvine, 20 parts of cotton rose hibiscus leaf, 50 parts of rheum officinale and 20 parts of Japanese ampelopsis into 700 parts of water, heating to boil, and decocting with small fire for about 2 hours;
step two, decocting and concentrating until 350 parts of water is left, filtering, adding 0.5 part of borneol into the filtrate, and heating to melt the borneol;
and thirdly, after the borneol is completely melted, stopping heating, adding 0.1 part of sodium benzoate, 0.2 part of sorbic acid and 3 parts of glycerin, and uniformly stirring to obtain the high-temperature burn and scald compound medicine in a spray form.
Example 2:
a preparation method of a spray-type high-temperature burn and scald compound medicine comprises the following steps:
adding 40 parts of sargent gloryvine, 25 parts of cotton rose hibiscus leaf, 40 parts of rheum officinale and 15 parts of Japanese ampelopsis into 600 parts of water, heating to boil, and decocting with small fire for 1.5-2 hours;
step two, decocting and concentrating until 300 parts of water is left, filtering, adding 0.4 part of borneol into the filtrate, and heating to melt the borneol;
and thirdly, after the borneol is completely melted, stopping heating, adding 0.08 part of sodium benzoate, 0.15 part of sorbic acid and 2.5 parts of glycerin, and uniformly stirring to obtain the high-temperature burn and scald compound medicine in a spray form.
Example 3:
a preparation method of a spray-type high-temperature burn and scald compound medicine comprises the following steps:
adding 60 parts of sargent gloryvine, 25 parts of cotton rose hibiscus leaf, 60 parts of rheum officinale and 25 parts of Japanese ampelopsis into 800 parts of water, heating to boil, and decocting with small fire for 2-2.5 hours;
step two, decocting and concentrating until 400 parts of water is left, filtering, adding 0.6 part of borneol into the filtrate, and heating to melt the borneol;
and thirdly, after the borneol is completely melted, stopping heating, adding 0.12 part of sodium benzoate, 0.25 part of sorbic acid and 3.5 parts of glycerol, and uniformly stirring to obtain the high-temperature burn and scald compound medicine in a spray form.
The high-temperature burn and scald compound medicine in the spray form obtained in the three embodiments has the advantages that the medicine effect is generally consistent, the proportion of the raw materials and the manufacturing process are slightly different, and the using method and the effect are as follows:
the using method comprises the following steps: filling the medicine into a spray bottle, spraying the medicine on the wound surface of a patient for 5-7 times every day, and adopting an exposure therapy; the use effect is as follows: 1 degree injury for 1-3 days, shallow 2 degree injury for 5-7 days, deep 2 degree injury for about 15-20 days, skin recovery, no scar left, convenient use, no pain, and good effects of clearing heat, detoxicating, cooling blood, relieving pain, promoting granulation and removing putrefaction.
Alternatively, another use method is as follows: immersing the medicine into a gauze block sterilized at high temperature, applying the gauze block to the wound surface of the burn and scald of the patient in a soaking degree, namely, dressing change is carried out 1 time per day, and the gauze block is used for one-to-two-degree wounds, mucous-rich wounds or suppurative infected wounds; the use effect is as follows: the composition can recover for about 1-20 days without leaving obvious scar, and has good effects of clearing heat and detoxicating, cooling blood and relieving pain, and resisting bacteria and diminishing inflammation.
Example 4:
a preparation method of a compound medicine for treating high-temperature burns and scalds in the form of ointment comprises the following steps:
step 1, adding 50 parts of sargent gloryvine, 20 parts of cotton rose hibiscus leaf, 50 parts of rheum officinale and 20 parts of Japanese ampelopsis into 600 parts of sesame oil, heating to boil, and decocting with small fire for about 1.5 hours;
step 2, decocting and concentrating until 300 parts of sesame oil is left, filtering, adding 5 parts of beeswax into the filtrate, and heating to melt the beeswax;
and 3, after the beeswax is completely melted, stopping heating, adding 0.5 part of borneol, and uniformly stirring to obtain the ointment-type high-temperature burn and scald compound medicine, and placing the ointment-type high-temperature burn and scald compound medicine in an environment below 0 ℃ for more than 20 hours for use.
Example 5:
a preparation method of a compound medicine for treating high-temperature burns and scalds in the form of ointment comprises the following steps:
step 1, adding 40 parts of sargent gloryvine, 15 parts of cotton rose hibiscus leaf, 40 parts of rheum officinale and 15 parts of Japanese ampelopsis into 500 parts of sesame oil, heating to boil, and decocting with small fire for 1-1.5 hours;
step 2, decocting and concentrating until 250 parts of sesame oil remains, filtering, adding 4 parts of beeswax into the filtrate, and heating to melt the beeswax;
and 3, after the beeswax is completely melted, stopping heating, adding 0.4 part of borneol, and uniformly stirring to obtain the ointment-type high-temperature burn and scald compound medicine, and placing the ointment-type high-temperature burn and scald compound medicine in an environment below 0 ℃ for more than 20 hours for use.
Example 6:
a preparation method of a compound medicine for treating high-temperature burns and scalds in the form of ointment comprises the following steps:
step 1, adding 60 parts of sargent gloryvine, 25 parts of cotton rose hibiscus leaf, 60 parts of rheum officinale and 25 parts of Japanese ampelopsis into 700 parts of sesame oil, heating to boil, and decocting with small fire for 1.5-2 hours;
step 2, decocting and concentrating until 350 parts of sesame oil remains, filtering, adding 6 parts of beeswax into the filtrate, and heating to melt the beeswax;
and 3, after the beeswax is completely melted, stopping heating, adding 0.6 part of borneol, and uniformly stirring to obtain the ointment-type high-temperature burn and scald compound medicine, and placing the ointment-type high-temperature burn and scald compound medicine in an environment below 0 ℃ for more than 20 hours for use.
The compound medicine for treating high-temperature burns and scalds in the form of the ointment obtained in the embodiments 4, 5 and 6 has the advantages of basically consistent efficacy, slightly different proportions of raw materials and manufacturing processes, and the use method and the effect are as follows:
the using method comprises the following steps: the medicine is applied to the wound dressing therapy of burns, scalds, erosion chronic ulcers and bedsores with one to three degrees, and the medicine is changed for 1 time every day; the use effect is as follows: 1-3 days of injury, 5-7 days of injury at shallow 2 degrees, 15-20 days of injury at deep 2 degrees and more than 20 days of injury at 3 degrees, the wound is completely healed, no obvious scar exists, and the effects of clearing heat, detoxicating, cooling blood, relieving pain, dissolving and promoting tissue regeneration are good.
The above embodiments are only preferred embodiments of the present invention, and are not limiting to the technical solutions of the present invention, and any technical solution that can be implemented on the basis of the above embodiments without inventive effort should be considered as falling within the scope of protection of the patent claims of the present invention.
Claims (6)
1. A compound medicine for treating high-temperature burns and scalds is characterized in that: comprises the following raw materials in parts by mass: 40-60 parts of sargent gloryvine, 15-25 parts of cotton rose hibiscus leaf, 40-60 parts of rheum emodi, and 15-25 parts of Japanese ampelopsis.
2. The high-temperature burn and scald compound medicine according to claim 1, wherein: the weight portions of the raw materials are as follows: 50 parts of sargent gloryvine, 20 parts of cotton rose hibiscus leaf, 50 parts of rheum emodi and 20 parts of ampelopsis japonica.
3. The high-temperature burn and scald compound medicine according to claim 1 or 2, which is characterized in that: the Gao Wenshao scald compound medicine is a spray and also comprises the following raw materials in parts by mass: 0.4-0.6 part of borneol, 0.08-0.12 part of sodium benzoate, 0.15-0.25 part of sorbic acid, 2.5-3.5 parts of glycerin and 300-400 parts of water.
4. The high-temperature burn and scald compound medicine according to claim 1 or 2, which is characterized in that: the Gao Wenshao scald compound medicine is ointment and also comprises the following raw materials in parts by mass: 0.4-0.6 part of borneol, 4-6 parts of beeswax and 250-350 parts of sesame oil.
5. A method for preparing the compound medicine for treating high-temperature burns and scalds as claimed in claim 3, which is characterized in that: the method comprises the following steps:
adding 40-60 parts of sargent gloryvine, 15-25 parts of cotton rose hibiscus leaf, 40-60 parts of rheum emodi and 15-25 parts of Japanese ampelopsis into 600-800 parts of water, heating to boil, and decocting with small fire for 1.5-2.5 hours;
step two, decocting and concentrating until 300-400 parts of water is left, filtering, adding 0.4-0.6 part of borneol into the filtrate, and heating to melt the borneol;
and thirdly, after the borneol is completely melted, stopping heating, adding 0.08-0.12 part of sodium benzoate, 0.15-0.25 part of sorbic acid and 2.5-3.5 parts of glycerin, and uniformly stirring to obtain the high-temperature burn and scald compound medicine in a spray form.
6. A method for preparing the compound medicine for treating high-temperature burns and scalds as claimed in claim 4, which is characterized in that: the method comprises the following steps:
step 1, adding 40-60 parts of sargent gloryvine, 15-25 parts of cotton rose leaves, 40-60 parts of rheum officinale and 15-25 parts of radix ampelopsis into 500-700 parts of sesame oil, heating to boil, and decocting with small fire for 1-2 hours;
step 2, decocting and concentrating until 250-350 parts of sesame oil remains, filtering, adding 4-6 parts of beeswax into the filtrate, and heating to melt the beeswax;
and 3, stopping heating after the beeswax is completely melted, adding 0.4-0.6 part of borneol, stirring uniformly to obtain the ointment-type high-temperature burn and scald compound medicine, and placing the ointment-type high-temperature burn and scald compound medicine in an environment below 0 ℃ for more than 20 hours for use.
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