CN111956750A - Fermented traditional Chinese medicine preparation for preventing and treating mastitis of dairy sheep and process thereof - Google Patents
Fermented traditional Chinese medicine preparation for preventing and treating mastitis of dairy sheep and process thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/86—Violaceae (Violet family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
Abstract
The invention discloses a fermented traditional Chinese medicine preparation for preventing and treating mastitis of a milk sheep, which relates to the field of traditional Chinese medicine preparations and comprises, by weight, 20-80 parts of ginger processed pinellia tuber, 25-75 parts of dried orange peel, 30-70 parts of poria cocos, 10-30 parts of liquorice, 50-70 parts of raw astragalus membranaceus, 80-120 parts of dandelion, 80-120 parts of Chinese violet, 35-65 parts of angelica tail, 180-220 parts of lactic acid bacteria, 80-120 parts of wheat middling and 85-115 parts of corn bran.
Description
Technical Field
The invention relates to the field of traditional Chinese medicine preparations, in particular to a fermented traditional Chinese medicine preparation for preventing and treating mastitis of a dairy goat and a process thereof.
Background
Mastitis is a common and most serious epidemic disease in the breeding of milk goats, and not only causes serious economic loss to milk goat breeders, but also increases the food safety risk of the goat milk and goat milk products. The dairy goat mastitis has not received much attention as the dairy goat mastitis in the past period, but has attracted wide attention as the breeding quantity of the dairy goats in China is increased sharply in recent years, and particularly the problem of the dairy goat mastitis is more prominent. Survey data on YaoOKANG (2013) show that: the average detection rate of the recessive mastitis of the milk goats is about 43.7 percent in China as a whole. Wherein, the Shanxi Fuping is 45.4 percent, and the Shandong is averagely 50.9 percent; yunnan averages 35.3%. Pathogenic bacteria causing recessive mastitis of dairy goats in China mainly comprise staphylococcus epidermidis, staphylococcus chromogenes, staphylococcus aureus, escherichia coli and streptococcus.
The traditional treatment of the mastitis of the dairy goat is to inject antibiotics into the dairy goat, and the method has the advantages of quick response, but has the defects of causing antibiotic residue in milk, increasing the drug resistance of the dairy goat and being not beneficial to the safety and sanitation of the dairy goat and the dairy goat. The development and the research of safe and reliable products for preventing and treating the mastitis of the dairy goat become wide demands in the industry. The Chinese herbal medicine as the feed additive has a long history and can be traced back to Shen nong's herbal Jing in the first three centuries of the Gongyuan. With the rapid development of modern feed industry, the traditional Chinese medicine feed additive is commonly added in the feed, which undoubtedly plays a great promoting role in the prevention and treatment of epidemic diseases in the livestock and poultry industry. Particularly, with the technical progress of the traditional Chinese medicine industry, the traditional Chinese medicine extract with stable and reliable quality and convenient use becomes a new product form in the feed additive market and is a carrier of the advanced technology of modern traditional Chinese medicines. For the reasons, the traditional Chinese medicine extract is obviously a safe and effective method for preventing and treating the mastitis of the dairy goat.
Disclosure of Invention
The invention aims to overcome the defects in the prior art, provides a fermented traditional Chinese medicine preparation for preventing and treating the mastitis of the dairy sheep and a process thereof, and has the advantage of good prevention and treatment effect.
In order to achieve the purpose, the invention adopts the following technical scheme: a fermented traditional Chinese medicine preparation for preventing and treating mastitis of a milk sheep is composed of, by weight, 20-80 parts of ginger processed pinellia tuber, 25-75 parts of dried orange peel, 30-70 parts of poria cocos, 10-30 parts of liquorice, 50-70 parts of raw astragalus membranaceus, 80-120 parts of dandelion, 80-120 parts of Chinese violet, 35-65 parts of angelica tail, 180-220 parts of lactic acid bacteria, 80-120 parts of wheat middling and 85-115 parts of corn bran.
In order to further optimize the present invention, the following technical solutions may be preferably selected:
a fermented traditional Chinese medicine preparation for preventing and treating mastitis of a milk sheep is composed of 50 parts by weight of rhizoma pinelliae preparata, 50 parts by weight of dried orange peel, 50 parts by weight of poria cocos, 20 parts by weight of liquorice, 60 parts by weight of raw astragalus membranaceus, 100 parts by weight of dandelion, 100 parts by weight of Chinese violet, 50 parts by weight of angelica sinensis tail, 200 parts by weight of lactic acid bacteria, 100 parts by weight of wheat middling and 100 parts by weight of corn bran.
A method for preparing a fermented traditional Chinese medicine preparation for preventing and treating the mastitis of the dairy sheep comprises the following steps:
the method comprises the following steps: preparing a solid raw material A, namely weighing ginger processed pinellia tuber, dried orange peel, poria cocos, liquorice, raw astragalus, dandelion, Chinese violet, angelica tail, lactic acid bacteria, wheat middling and corn bran according to the weight parts, adding the weighed materials into a mixing crusher, and sieving the materials by a 100-mesh sieve to obtain the solid raw material A for later use;
step two: preparing a liquid raw material B, namely weighing wheat middling, baking soda, calcium stone powder, enterococcus faecalis and cheese fungi in sequence, adding purified water, stirring and mixing to prepare the liquid raw material B, wherein the weight of the liquid raw material B is 30% of that of the solid raw material A, and the wheat middling, the baking soda and the calcium stone powder are 10 in parts by weight: 0.1: 10 and the balance of purified water,
step three: mixing the raw materials, namely putting the solid raw material A prepared in the step one into a groove type mixer, and then adding the liquid raw material B prepared in the step two into the groove type mixer in three times, wherein the input amount of the liquid raw material B accounts for 10% of the total weight of the liquid raw material B each time;
step four: and (3) bagging and fermenting, namely putting the mixed raw material C prepared in the third step into a packaging bag according to the standard of 50 kg/bag, sealing and exhausting air, observing that the finished product of the packaging bag is qualified after heating after 3-5 days, and storing for 21 days, and opening to smell the sour and sweet taste to obtain the qualified product.
The invention has the beneficial effects that:
the invention adopts the pharmaceutical composition of 50 parts of pinellia ternate, 50 parts of dried orange peel, 50 parts of tuckahoe, 20 parts of liquorice, 60 parts of raw astragalus, 100 parts of dandelion, 100 parts of Chinese violet, 50 parts of angelica tail, 200 parts of lactic acid bacteria, 100 parts of wheat middling and 100 parts of corn bran, and has the characteristics of high drug effect, no toxic or side effect and no residue by preventing and treating the mastitis of the milch goat
Example 1:
a fermented traditional Chinese medicine preparation for preventing and treating mastitis of a milk sheep is composed of, by weight, 20-80 parts of ginger processed pinellia tuber, 25-75 parts of dried orange peel, 30-70 parts of poria cocos, 10-30 parts of liquorice, 50-70 parts of raw astragalus membranaceus, 80-120 parts of dandelion, 80-120 parts of Chinese violet, 35-65 parts of angelica tail, 180-220 parts of lactic acid bacteria, 80-120 parts of wheat middling and 85-115 parts of corn bran.
Example 1
A fermented traditional Chinese medicine preparation for preventing and treating mastitis of a milk sheep comprises, by weight, 20 parts of rhizoma pinelliae preparata, 25 parts of pericarpium citri reticulatae, 30 parts of poria cocos, 10 parts of liquorice, 50 parts of raw astragalus membranaceus, 80 parts of dandelion, 80 parts of Chinese violet, 35 parts of angelica sinensis, 180 parts of lactic acid bacteria, 80 parts of wheat middling and 85 parts of corn bran.
Example 2
A fermented traditional Chinese medicine preparation for preventing and treating mastitis of a milk sheep is composed of 50 parts by weight of rhizoma pinelliae preparata, 50 parts by weight of dried orange peel, 50 parts by weight of poria cocos, 20 parts by weight of liquorice, 60 parts by weight of raw astragalus membranaceus, 100 parts by weight of dandelion, 100 parts by weight of Chinese violet, 50 parts by weight of angelica sinensis tail, 200 parts by weight of lactic acid bacteria, 100 parts by weight of wheat middling and 100 parts by weight of corn bran.
Example 3
A fermented traditional Chinese medicine preparation for preventing and treating mastitis of a milk sheep is composed of, by weight, 80 parts of ginger processed pinellia, 75 parts of dried orange peel, 70 parts of poria cocos, 30 parts of liquorice, 70 parts of raw astragalus membranaceus, 120 parts of dandelion, 120 parts of Chinese violet, 65 parts of angelica sinensis tails, 220 parts of lactic acid bacteria, 120 parts of wheat middling and 115 parts of corn husks.
A method for preparing the fermented traditional Chinese medicine preparation for preventing and treating the mastitis of the dairy sheep as claimed in claim 1, comprising the following steps:
the method comprises the following steps: preparing a solid raw material A, namely weighing ginger processed pinellia tuber, dried orange peel, poria cocos, liquorice, raw astragalus, dandelion, Chinese violet, angelica tail, lactic acid bacteria, wheat middling and corn bran according to the weight parts, adding the weighed materials into a mixing crusher, and sieving the materials by a 100-mesh sieve to obtain the solid raw material A for later use;
step two: preparing a liquid raw material B, namely weighing wheat middling, baking soda, calcium stone powder, enterococcus faecalis and cheese fungi in sequence, adding purified water, stirring and mixing to prepare the liquid raw material B, wherein the weight of the liquid raw material B is 30% of that of the solid raw material A, and the wheat middling, the baking soda and the calcium stone powder are 10 in parts by weight: 0.1: 10 and the balance of purified water,
step three: mixing the raw materials, namely putting the solid raw material A prepared in the step one into a groove type mixer, and then adding the liquid raw material B prepared in the step two into the groove type mixer in three times, wherein the input amount of the liquid raw material B accounts for 10% of the total weight of the liquid raw material B each time;
step four: and (3) bagging and fermenting, namely putting the mixed raw material C prepared in the third step into a packaging bag according to the standard of 50 kg/bag, sealing and exhausting air, observing that the finished product of the packaging bag is qualified after heating after 3-5 days, and storing for 21 days, and opening to smell the sour and sweet taste to obtain the qualified product.
Wheat middling 10%, baking soda 0.1%, calcium stone powder 10%, enterococcus faecalis 100 g/g 200 hundred million, casei 100 ml/ml 100 hundred million, purified water is added to the weight of 30% of the finished product,
the method comprises the following steps of taking local Chinese medicinal materials, using 80% of the Chinese medicinal materials in a prescription, selecting qualified Chinese medicinal materials after detecting heavy metal residues, adding 10% of wheat middling, 0.1% of sodium bicarbonate and 10% of calcium stone powder, 100 g of 200 hundred million enterococcus faecalis per gram and 100 ml of 100 hundred million casei per ml, adding purified water to reach the weight of 30% of the finished product amount, putting the raw materials into a 500kg weight trough type mixer, adding 10% of mixed liquid, mixing for 5 minutes, adding 10%, mixing for 15 minutes in total for three times, balancing, and forming into a group by hand and dispersing by hand to be uniform. Then putting the mixture into a packaging bag by taking 50kg as a unit, sealing and exhausting air, observing that the finished product of the packaging bag is qualified after heating after 3-5 days, and opening and smelling the sour and sweet taste after storing for 21 days to obtain the qualified product
Experimental data:
samples of the same product from example 1, example 2 and example 3 were taken and 80 dairy goats in the dry period of a certain scale pasture were divided into four groups of 20 goats. The samples of examples 1, 2 and 3 were added to the feed at a ratio of 5% in the first, second and third groups, and the control group was normally maintained in the fourth group. And counting the number of mastitis and invisible mastitis of each group of the milk goats by the time of calving.
| Group of | Number of milk goats | Cure rate of mastitis |
| Example 1 | 20 | 85(17/20) |
| Example 2 | 20 | 86(18/20) |
| Example 3 | 20 | 85(16/20) |
| Control group | 20 | 45(9/20) |
As can be seen from the data in the table above, the clinical mastitis milk goat uses the samples 1, 2 and 3 in the treatment process, and compared with the unused sick milk goat, the cure rate in one week is obviously improved, so the treatment cost of the sick milk goat can be greatly reduced, the treatment rate can be improved, and the treatment cost can be reduced.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments or portions thereof without departing from the spirit and scope of the invention.
Claims (3)
1. A fermented traditional Chinese medicine preparation for preventing and treating mastitis of a milk sheep is composed of, by weight, 20-80 parts of ginger processed pinellia tuber, 25-75 parts of dried orange peel, 30-70 parts of poria cocos, 10-30 parts of liquorice, 50-70 parts of raw astragalus membranaceus, 80-120 parts of dandelion, 80-120 parts of Chinese violet, 35-65 parts of angelica tail, 180-220 parts of lactic acid bacteria, 80-120 parts of wheat middling and 85-115 parts of corn bran.
2. The fermented traditional Chinese medicine preparation for preventing and treating the mastitis of the dairy sheep as claimed in claim 1, which comprises 50 parts by weight of rhizoma pinelliae preparata, 50 parts by weight of dried orange peel, 50 parts by weight of poria cocos, 20 parts by weight of liquorice, 60 parts by weight of raw astragalus membranaceus, 100 parts by weight of dandelion, 100 parts by weight of philippine violet herb, 50 parts by weight of angelica tail, 200 parts by weight of lactic acid bacteria, 100 parts by weight of wheat middling and 100 parts by weight of corn bran.
3. A method for preparing the fermented traditional Chinese medicine preparation for preventing and treating the mastitis of the dairy sheep as claimed in claim 1, comprising the following steps:
the method comprises the following steps: preparing a solid raw material A, namely weighing ginger processed pinellia tuber, dried orange peel, poria cocos, liquorice, raw astragalus, dandelion, Chinese violet, angelica tail, lactic acid bacteria, wheat middling and corn bran according to the weight parts, adding the weighed materials into a mixing crusher, and sieving the materials by a 100-mesh sieve to obtain the solid raw material A for later use;
step two: preparing a liquid raw material B, namely weighing wheat middling, baking soda, calcium stone powder, enterococcus faecalis and cheese fungi in sequence, adding purified water, stirring and mixing to prepare the liquid raw material B, wherein the weight of the liquid raw material B is 30% of that of the solid raw material A, and the wheat middling, the baking soda and the calcium stone powder are 10 in parts by weight: 0.1: 10, the balance being purified water;
step three: mixing raw materials, namely putting the solid raw material A prepared in the step one into a groove type mixing machine, then adding the liquid raw material B prepared in the step two into the groove type mixing machine in three times, wherein the adding amount of the liquid raw material B accounts for 10% of the total weight of the liquid raw material B every time, the three times account for 15 minutes, then mixing the raw materials evenly, and performing hand-grasping to form a cluster, and loosening the hands to obtain a qualified product, thus preparing a mixed raw material C;
step four: and (3) bagging and fermenting, namely putting the mixed raw material C prepared in the third step into a packaging bag according to the standard of 50 kg/bag, sealing and exhausting air, observing that the finished product of the packaging bag is qualified after heating after 3-5 days, and storing for 21 days, and opening to smell the sour and sweet taste to obtain the qualified product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202011017622.7A CN111956750A (en) | 2020-09-24 | 2020-09-24 | Fermented traditional Chinese medicine preparation for preventing and treating mastitis of dairy sheep and process thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202011017622.7A CN111956750A (en) | 2020-09-24 | 2020-09-24 | Fermented traditional Chinese medicine preparation for preventing and treating mastitis of dairy sheep and process thereof |
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| CN202011017622.7A Pending CN111956750A (en) | 2020-09-24 | 2020-09-24 | Fermented traditional Chinese medicine preparation for preventing and treating mastitis of dairy sheep and process thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105166450A (en) * | 2015-08-06 | 2015-12-23 | 钱峰 | Dairy cow feed for preventing and treating mastitis and preparation method thereof |
| CN107586746A (en) * | 2017-10-24 | 2018-01-16 | 山东宝来利来生物工程股份有限公司 | One plant of lactic acid bacteria with preventing and treating mastitis for milk cows effect and its application |
| CN107624969A (en) * | 2017-09-28 | 2018-01-26 | 淮北市渭水源农业有限公司 | A kind of feed addictive for controlling cow subclinical mastitis, reducing body cell and preparation method thereof |
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2020
- 2020-09-24 CN CN202011017622.7A patent/CN111956750A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105166450A (en) * | 2015-08-06 | 2015-12-23 | 钱峰 | Dairy cow feed for preventing and treating mastitis and preparation method thereof |
| CN107624969A (en) * | 2017-09-28 | 2018-01-26 | 淮北市渭水源农业有限公司 | A kind of feed addictive for controlling cow subclinical mastitis, reducing body cell and preparation method thereof |
| CN107586746A (en) * | 2017-10-24 | 2018-01-16 | 山东宝来利来生物工程股份有限公司 | One plant of lactic acid bacteria with preventing and treating mastitis for milk cows effect and its application |
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