CN111954524A - 秋水仙碱抑制肿瘤生长和转移的用途 - Google Patents

秋水仙碱抑制肿瘤生长和转移的用途 Download PDF

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Publication number
CN111954524A
CN111954524A CN201980023515.4A CN201980023515A CN111954524A CN 111954524 A CN111954524 A CN 111954524A CN 201980023515 A CN201980023515 A CN 201980023515A CN 111954524 A CN111954524 A CN 111954524A
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CN
China
Prior art keywords
cancer
colchicine
release
tumor
subject
Prior art date
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Pending
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CN201980023515.4A
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English (en)
Chinese (zh)
Inventor
M·瑞尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Murray and Poole Enterprises Ltd
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Murray and Poole Enterprises Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Murray and Poole Enterprises Ltd filed Critical Murray and Poole Enterprises Ltd
Publication of CN111954524A publication Critical patent/CN111954524A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201980023515.4A 2018-02-02 2019-02-01 秋水仙碱抑制肿瘤生长和转移的用途 Pending CN111954524A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862625354P 2018-02-02 2018-02-02
US62/625,354 2018-02-02
PCT/EP2019/052492 WO2019149884A1 (en) 2018-02-02 2019-02-01 Use of colchicine to inhibit tumor growth and metastases

Publications (1)

Publication Number Publication Date
CN111954524A true CN111954524A (zh) 2020-11-17

Family

ID=65278359

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980023515.4A Pending CN111954524A (zh) 2018-02-02 2019-02-01 秋水仙碱抑制肿瘤生长和转移的用途

Country Status (7)

Country Link
US (3) US11534415B2 (https=)
EP (1) EP3746061A1 (https=)
JP (3) JP2022514997A (https=)
CN (1) CN111954524A (https=)
CA (1) CA3089781A1 (https=)
EA (1) EA202091736A1 (https=)
WO (1) WO2019149884A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021089715A1 (en) * 2019-11-06 2021-05-14 Murray And Poole Enterprises, Ltd. Use of colchicine in the treatment and prevention of lung cancer
CN115068483B (zh) * 2021-03-16 2023-10-31 中国科学院上海药物研究所 Mln4924在缓解秋水仙碱中毒中的新用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1748671A (zh) * 2005-08-30 2006-03-22 孔庆忠 含抗有丝分裂药物的缓释注射剂
WO2015069770A1 (en) * 2013-11-05 2015-05-14 Cognate Bioservices, Inc. Combinations of checkpoint inhibitors and therapeutics to treat cancer
CN105307643A (zh) * 2013-04-16 2016-02-03 默里和普尔企业有限公司 秋水仙碱的缓释制剂及其使用方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3173876A (en) 1960-05-27 1965-03-16 John C Zobrist Cleaning methods and compositions
US3276586A (en) 1963-08-30 1966-10-04 Rosaen Filter Co Indicating means for fluid filters
US3546142A (en) 1967-01-19 1970-12-08 Amicon Corp Polyelectrolyte structures
US3541006A (en) 1968-07-03 1970-11-17 Amicon Corp Ultrafiltration process
US3541005A (en) 1969-02-05 1970-11-17 Amicon Corp Continuous ultrafiltration of macromolecular solutions
US4285987A (en) 1978-10-23 1981-08-25 Alza Corporation Process for manufacturing device with dispersion zone
WO1998046769A1 (en) 1997-04-11 1998-10-22 Dendreon Corporation Composition and method for inducing an immune response against tumour-related antigens
CN101485637B (zh) 2008-01-18 2011-03-30 普尔药物科技开发（深圳）有限公司 秋水仙碱骨架控释片或胶囊
EA032515B1 (ru) 2012-11-02 2019-06-28 Марри Энд Пул Энтерпрайзес, Лтд. Лечение или профилактика сердечно-сосудистых явлений с использованием колхицина

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1748671A (zh) * 2005-08-30 2006-03-22 孔庆忠 含抗有丝分裂药物的缓释注射剂
CN105307643A (zh) * 2013-04-16 2016-02-03 默里和普尔企业有限公司 秋水仙碱的缓释制剂及其使用方法
WO2015069770A1 (en) * 2013-11-05 2015-05-14 Cognate Bioservices, Inc. Combinations of checkpoint inhibitors and therapeutics to treat cancer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ASLI MUVAFFAK等: "Prolonged Cytotoxic Effect of Colchicine Released from Biodegradable Microspheres", 《J BIOMED MATER RES PART》 *

Also Published As

Publication number Publication date
US11877991B2 (en) 2024-01-23
CA3089781A1 (en) 2019-08-08
WO2019149884A1 (en) 2019-08-08
JP2024050581A (ja) 2024-04-10
JP2025134752A (ja) 2025-09-17
US11534415B2 (en) 2022-12-27
US20210046024A1 (en) 2021-02-18
US20230137776A1 (en) 2023-05-04
US20240099999A1 (en) 2024-03-28
EA202091736A1 (ru) 2020-10-19
JP2022514997A (ja) 2022-02-17
EP3746061A1 (en) 2020-12-09

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