CN111954520A - 连续制备喷雾溶液的喷雾干燥方法 - Google Patents

连续制备喷雾溶液的喷雾干燥方法 Download PDF

Info

Publication number
CN111954520A
CN111954520A CN201980025054.4A CN201980025054A CN111954520A CN 111954520 A CN111954520 A CN 111954520A CN 201980025054 A CN201980025054 A CN 201980025054A CN 111954520 A CN111954520 A CN 111954520A
Authority
CN
China
Prior art keywords
suspension
component
spray
buffer tank
particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201980025054.4A
Other languages
English (en)
Chinese (zh)
Inventor
J·维森特
C·萨库托
R·费雷拉
M·特姆特姆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hovione Scientia Ltd
Original Assignee
Hovione Scientia Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hovione Scientia Ltd filed Critical Hovione Scientia Ltd
Publication of CN111954520A publication Critical patent/CN111954520A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/005—Drying solid materials or objects by processes not involving the application of heat by dipping them into or mixing them with a chemical liquid, e.g. organic; chemical, e.g. organic, dewatering aids

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medicinal Preparation (AREA)
  • Glanulating (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201980025054.4A 2018-02-22 2019-02-22 连续制备喷雾溶液的喷雾干燥方法 Pending CN111954520A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PT110585 2018-02-22
PT110585A PT110585B (pt) 2018-02-22 2018-02-22 Processo de produção contínua de partículas compreendendo secagem por atomização com preparação contínua da solução de atomização
PCT/GB2019/050495 WO2019162688A1 (en) 2018-02-22 2019-02-22 A spray drying process with continuous preparation of spray solution

Publications (1)

Publication Number Publication Date
CN111954520A true CN111954520A (zh) 2020-11-17

Family

ID=65729388

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980025054.4A Pending CN111954520A (zh) 2018-02-22 2019-02-22 连续制备喷雾溶液的喷雾干燥方法

Country Status (10)

Country Link
US (1) US11752105B2 (https=)
EP (1) EP3755307B1 (https=)
JP (1) JP7481259B2 (https=)
KR (1) KR102784679B1 (https=)
CN (1) CN111954520A (https=)
AU (1) AU2019224665B2 (https=)
CA (1) CA3091546C (https=)
IL (1) IL276826B2 (https=)
PT (1) PT110585B (https=)
WO (1) WO2019162688A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT110585B (pt) 2018-02-22 2021-04-22 Hovione Farmaciencia Sa Processo de produção contínua de partículas compreendendo secagem por atomização com preparação contínua da solução de atomização
US12466883B1 (en) 2024-05-13 2025-11-11 Lumen Bioscience, Inc. Leptin compositions and methods of making and using the same to support weight loss and/or maintenance
WO2026013055A1 (en) 2024-07-09 2026-01-15 Hovione Farmaciência S.A., Methods and systems for preparing feed solutions for spray drying

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020071870A1 (en) * 1999-06-28 2002-06-13 Vinay K. Sharma Preparation of micron-size pharmaceutical particles by microfluidization
US20050031692A1 (en) * 2003-08-04 2005-02-10 Pfizer Inc Spray drying processes for forming solid amorphous dispersions of drugs and polymers
WO2016156841A1 (en) * 2015-03-31 2016-10-06 Hovione Scientia Limited Continuous production of particles
US20170209372A1 (en) * 2014-08-01 2017-07-27 Hovione International Ltd A Method of Preparing Amorphous Solid Dispersion in Submicron Range by Co-Precipitation
WO2017129988A1 (en) * 2016-01-28 2017-08-03 Hovione Scientia Limited Continuous complexation of active pharmaceutical ingredients

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5222807A (en) 1991-03-12 1993-06-29 Gaco Manufacturing Division Of Gaddis Petroleum Corporation Low shear polymer dissolution apparatus
FI98892C (fi) 1994-11-15 1997-09-10 Turun Asennusteam Oy Polymeerien liuotusmenetelmä ja -laite
CA2299284C (en) 1997-08-05 2008-07-08 Mfic Corporation Multiple stream high pressure mixer/reactor
ZA200905094B (en) * 2006-12-22 2010-09-29 Yuhan Corp Revaprazan-containing solid dispersion and process for the preparation thereof
US8187554B2 (en) 2008-04-23 2012-05-29 Microfluidics International Corporation Apparatus and methods for nanoparticle generation and process intensification of transport and reaction systems
WO2010111132A2 (en) 2009-03-27 2010-09-30 Bend Research, Inc. Spray-drying process
CN105142767B (zh) 2013-03-14 2017-12-12 艺康美国股份有限公司 聚合物溶解系统
KR20160120739A (ko) * 2014-02-11 2016-10-18 램 테라퓨틱스, 인코포레이티드 림프관평활근종증의 치료를 위한 라파마이신
PL3166986T3 (pl) * 2014-07-10 2023-07-31 Huntsman Petrochemical Llc Kompozycja zmniejszająca ilość aldehydów emitowanych z pianek poliuretanowych
US9432572B2 (en) * 2014-12-01 2016-08-30 Here Global B.V. Method and apparatus for automatic prediction of dynamic exposure
PT110585B (pt) 2018-02-22 2021-04-22 Hovione Farmaciencia Sa Processo de produção contínua de partículas compreendendo secagem por atomização com preparação contínua da solução de atomização

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020071870A1 (en) * 1999-06-28 2002-06-13 Vinay K. Sharma Preparation of micron-size pharmaceutical particles by microfluidization
US20050031692A1 (en) * 2003-08-04 2005-02-10 Pfizer Inc Spray drying processes for forming solid amorphous dispersions of drugs and polymers
US20170209372A1 (en) * 2014-08-01 2017-07-27 Hovione International Ltd A Method of Preparing Amorphous Solid Dispersion in Submicron Range by Co-Precipitation
WO2016156841A1 (en) * 2015-03-31 2016-10-06 Hovione Scientia Limited Continuous production of particles
WO2017129988A1 (en) * 2016-01-28 2017-08-03 Hovione Scientia Limited Continuous complexation of active pharmaceutical ingredients

Also Published As

Publication number Publication date
WO2019162688A1 (en) 2019-08-29
IL276826B1 (en) 2024-10-01
CA3091546A1 (en) 2019-08-29
EP3755307A1 (en) 2020-12-30
IL276826A (en) 2020-10-29
EP3755307C0 (en) 2023-08-23
PT110585B (pt) 2021-04-22
KR20200123452A (ko) 2020-10-29
PT110585A (pt) 2019-08-22
EP3755307B1 (en) 2023-08-23
US20210077405A1 (en) 2021-03-18
US11752105B2 (en) 2023-09-12
IL276826B2 (en) 2025-02-01
AU2019224665A1 (en) 2020-11-26
JP2021514954A (ja) 2021-06-17
CA3091546C (en) 2024-11-12
AU2019224665B2 (en) 2024-09-05
JP7481259B2 (ja) 2024-05-10
KR102784679B1 (ko) 2025-03-21

Similar Documents

Publication Publication Date Title
Kumar et al. Particle size reduction techniques of pharmaceutical compounds for the enhancement of their dissolution rate and bioavailability
Dalvi et al. Controlling particle size of a poorly water-soluble drug using ultrasound and stabilizers in antisolvent precipitation
Vandana et al. An overview on in situ micronization technique–An emerging novel concept in advanced drug delivery
Shariati et al. Recent developments in particle design using supercritical fluids
US9901893B2 (en) Apparatus and method for producing dispersions and solids
US7404828B1 (en) Method for the production of particles
Xia et al. Application of precipitation methods for the production of water-insoluble drug nanocrystals: production techniques and stability of nanocrystals
JP2021073175A (ja) 粒子の連続製造方法
CN105125502A (zh) 制备具有低粒度的药物活性成分的方法
Gao et al. Crystallization methods for preparation of nanocrystals for drug delivery system
PT107568B (pt) Processo de secagem por atomização para a produção de pós com propriedades melhoradas.
CN111954520A (zh) 连续制备喷雾溶液的喷雾干燥方法
CN101011316A (zh) 一种利用微反应器制备微粉化药物的方法
JP2006517465A (ja) 粒子形成方法
Nguyen et al. Nanoprecipitation for poorly water-soluble drugs
US20060153921A1 (en) Method for preparation of particles from solution-in-supercritical fluid or compressed gas emulsions
Tan et al. Particle formation using supercritical fluids: pharmaceutical applications
JP2021514954A5 (https=)
Charbit et al. Methods of particle production
Arpargaus et al. Enhanced solubility of poorly soluble drugs via spray drying
Chaturvedi et al. Solubility enhancement of poorly water soluble drugs by solid dispersion
ES2964411T3 (es) Un proceso de secado por pulverización con preparación continua de solución de pulverización
JPWO2019162688A5 (https=)
Avanti DEVELOPMENT OF ORAL DELIVERY SOLID DISPERSION NANOPARTICLE USING ULTRASONIC SPRAY DRYING METHOD
BR102017015979A2 (pt) Processo de secagem por atomização utilizando a preparação contínua de soluções com compostos com baixa solubilidade e/ou baixa estabilidade

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination