CN111936146A - α聚谷氨酸化四氢叶酸及其用途 - Google Patents

α聚谷氨酸化四氢叶酸及其用途 Download PDF

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Publication number
CN111936146A
CN111936146A CN201980024661.9A CN201980024661A CN111936146A CN 111936146 A CN111936146 A CN 111936146A CN 201980024661 A CN201980024661 A CN 201980024661A CN 111936146 A CN111936146 A CN 111936146A
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alpha
thf
composition
tetrahydrofolate
cancer
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CN201980024661.9A
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Chinese (zh)
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C·尼基萨
V·M·莫约
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LEAF Holdings Group LLC
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LEAF Holdings Group LLC
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201980024661.9A 2018-02-07 2019-02-07 α聚谷氨酸化四氢叶酸及其用途 Pending CN111936146A (zh)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US201862627741P 2018-02-07 2018-02-07
US62/627,741 2018-02-07
US201862630825P 2018-02-14 2018-02-14
US201862630820P 2018-02-14 2018-02-14
US62/630,825 2018-02-14
US62/630,820 2018-02-14
US201862636294P 2018-02-28 2018-02-28
US62/636,294 2018-02-28
US201862662374P 2018-04-25 2018-04-25
US62/662,374 2018-04-25
US201862702732P 2018-07-24 2018-07-24
US62/702,732 2018-07-24
US201862764943P 2018-08-17 2018-08-17
US62/764,943 2018-08-17
PCT/US2019/016955 WO2019157120A1 (en) 2018-02-07 2019-02-07 Alpha polyglutamated tetrahydrofolates and uses thereof

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CN111936146A true CN111936146A (zh) 2020-11-13

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US (2) US12336994B2 (https=)
EP (1) EP3749319A4 (https=)
JP (3) JP7514533B2 (https=)
CN (1) CN111936146A (https=)
CA (1) CA3090506A1 (https=)
WO (1) WO2019157120A1 (https=)

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EP3749321A4 (en) * 2018-02-07 2022-03-09 L.E.A.F Holdings Group LLC Gamma polyglutamated antifolates and uses thereof
EP3749311A4 (en) 2018-02-07 2022-07-06 L.E.A.F Holdings Group LLC PEMETREXED POLYGLUTAMATE GAMMA COMPOSITIONS AND THEIR USES
JP7491573B2 (ja) 2018-02-07 2024-05-28 エル．イー．エー．エフ． ホールディングス グループ エルエルシー アルファポリグルタミン酸化メトトレキセートおよびその使用
US12246015B2 (en) 2018-02-07 2025-03-11 L.E.A.F. Holdings Group Llc Alpha polyglutamated raltitrexed and uses thereof
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