CN111920826A - Low-rust-taste calcium, iron and zinc chewable tablet and preparation process thereof - Google Patents
Low-rust-taste calcium, iron and zinc chewable tablet and preparation process thereof Download PDFInfo
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- CN111920826A CN111920826A CN202010903111.9A CN202010903111A CN111920826A CN 111920826 A CN111920826 A CN 111920826A CN 202010903111 A CN202010903111 A CN 202010903111A CN 111920826 A CN111920826 A CN 111920826A
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- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title claims abstract description 56
- 239000007910 chewable tablet Substances 0.000 title claims abstract description 33
- 229910052742 iron Inorganic materials 0.000 title claims abstract description 29
- 229940068682 chewable tablet Drugs 0.000 title claims abstract description 26
- 239000011575 calcium Substances 0.000 title claims abstract description 22
- 229910052791 calcium Inorganic materials 0.000 title claims abstract description 22
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims abstract description 21
- 239000011701 zinc Substances 0.000 title claims abstract description 19
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 title claims abstract description 18
- 229910052725 zinc Inorganic materials 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 24
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims abstract description 24
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000000796 flavoring agent Substances 0.000 claims abstract description 15
- 238000000034 method Methods 0.000 claims abstract description 15
- 238000001035 drying Methods 0.000 claims abstract description 14
- 238000002156 mixing Methods 0.000 claims abstract description 13
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract description 12
- 229910000019 calcium carbonate Inorganic materials 0.000 claims abstract description 12
- 239000004222 ferrous gluconate Substances 0.000 claims abstract description 12
- 229960001645 ferrous gluconate Drugs 0.000 claims abstract description 12
- 235000013924 ferrous gluconate Nutrition 0.000 claims abstract description 12
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- VRIVJOXICYMTAG-IYEMJOQQSA-L iron(ii) gluconate Chemical compound [Fe+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O VRIVJOXICYMTAG-IYEMJOQQSA-L 0.000 claims abstract description 12
- 239000000600 sorbitol Substances 0.000 claims abstract description 12
- 239000011787 zinc oxide Substances 0.000 claims abstract description 12
- 235000013355 food flavoring agent Nutrition 0.000 claims abstract description 11
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- 230000008569 process Effects 0.000 claims abstract description 11
- 239000003765 sweetening agent Substances 0.000 claims abstract description 11
- 239000000463 material Substances 0.000 claims abstract description 10
- JYMOQWNEIZBVFC-UHFFFAOYSA-N [Fe].[Zn].[Ca] Chemical compound [Fe].[Zn].[Ca] JYMOQWNEIZBVFC-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims abstract description 8
- 239000011159 matrix material Substances 0.000 claims description 23
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical group C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 18
- 239000002245 particle Substances 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 239000011230 binding agent Substances 0.000 claims description 4
- 235000019634 flavors Nutrition 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 3
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- 239000008187 granular material Substances 0.000 claims description 2
- 238000005469 granulation Methods 0.000 claims description 2
- 230000003179 granulation Effects 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 238000005550 wet granulation Methods 0.000 claims description 2
- 230000001055 chewing effect Effects 0.000 abstract description 2
- 239000002552 dosage form Substances 0.000 abstract description 2
- 206010048259 Zinc deficiency Diseases 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 102000001554 Hemoglobins Human genes 0.000 description 3
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- 239000011573 trace mineral Substances 0.000 description 2
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- 206010058314 Dysplasia Diseases 0.000 description 1
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- 206010053759 Growth retardation Diseases 0.000 description 1
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- 241001465754 Metazoa Species 0.000 description 1
- 102000004243 Tubulin Human genes 0.000 description 1
- 108090000704 Tubulin Proteins 0.000 description 1
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- 150000001669 calcium Chemical class 0.000 description 1
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- 229940082629 iron antianemic preparations Drugs 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/10—Carbonates; Bicarbonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/295—Iron group metal compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
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- Health & Medical Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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Abstract
The invention provides a calcium, iron and zinc chewable tablet with low rust taste, which comprises: the main raw materials, main auxiliary materials, an acidity regulator, a sweetening agent and a flavoring agent comprise: calcium carbonate, ferrous gluconate, zinc oxide, main auxiliary materials include: sorbitol and white granulated sugar are combined according to the following percentages: calcium carbonate (30% -40%), ferrous gluconate (1% -2%), zinc oxide (0.1% -0.2%), sorbitol (30% -40%), white granulated sugar (20% -30%), acidity regulator (0.2% -1%), sweetening agent (0.1% -0.5%), flavoring agent (0.1% -0.5%), and the product is novel in dosage form, sour and delicious in taste and free of iron rust. Meanwhile, the invention provides a preparation method of the low-iron-rust-taste calcium-iron-zinc chewable tablet, which comprises the following steps: the chewable tablet is prepared by the steps of mixing, granulating, drying and tabletting, and has reasonable process, stable product specification and good chewing effect.
Description
Technical Field
The invention relates to the field of chewable tablets, in particular to a calcium, iron and zinc chewable tablet with low iron rust taste and a preparation process thereof.
Background
The normal human body contains 1000-1200g of calcium, 99.3 percent of the calcium is concentrated in tooth tissues, only 0.1 percent of the calcium is in extracellular fluid, and the calcium content of soft tissues of the whole body accounts for 0.6 to 0.9 percent in total.
Calcium in the bone and teeth, in mineral form; calcium in soft tissues and body fluids exists in free or bound form, and this calcium is collectively called the miscible calcium pool. Calcium in the body constitutes bones and teeth on the one hand, and participates in various physiological functions and metabolic processes on the other hand. Deficiency of calcium in the body to some extent may cause deficiency.
Iron is an essential trace element with the largest content in a human body; is also one of the most studied trace elements; dietary iron intake in people is often higher than RDI, but the phenomena of iron deficiency anemia and lower than normal hemoglobin in the human body are common and still one of the major nutritional problems in the world.
The scientific method that has been used in the 18 th century has shown that iron is the major component of blood, and the treatment of "lack of color substance in blood" in young women with iron preparations was achieved in 1823. In 1928, it was demonstrated that anemia is due to iron deficiency, and fortification of iron in milk powder prevented or reduced anemia. 1932 it was confirmed that inorganic iron can be used for the synthesis of hemoglobin, i.e. hemoglobin, and the role of iron in human body was basically elucidated. Although iron is a major cause of the wide spread anemia, many factors that promote or inhibit iron absorption and bioavailability have been shown and need to be thoroughly discussed.
Zinc was first recognized as a valuable element in 1509, 1869 with evidence that zinc is essential to plants and in 1934 to animals. Because zinc is widely present in food, it has been considered that the natural occurrence of zinc deficiency in humans is extremely difficult. In 1961, Prasad et al first revealed important roles in human nutrition in epidemiological analyses of anorexia, growth retardation, sexual dysplasia and nutritional zinc deficiency in children in Iran. The evidence of zinc deficiency in humans has then been confirmed by a number of studies. The clinical significance and public health significance of zinc as an essential nutrient for human bodies are further confirmed.
The function of zinc is generally divided into three parts: catalytic, results, and regulatory functions. Recent studies have shown that these functions are supporting and intersecting each other, and new evidence has emerged to support each function. Zinc is also the active center of many enzymes, a component of biological membranes, and is also a roll of material necessary for RNA and DNA and ribosome stabilization. Also a combination of many hormone receptors, also have a harmonic effect on tubulin polymers. It is therefore also based on zinc deficiency causing the hyperandrogenic and severe functional impairment of the human body.
The traditional calcium, iron and zinc chewable tablet has unreasonable formula, poor taste and iron rust taste.
Disclosure of Invention
In view of the above-mentioned problems in the background art, the present invention provides a calcium, iron and zinc chewable tablet with low rust taste, comprising: the main raw materials, main auxiliary materials, an acidity regulator, a sweetening agent and a flavoring agent, wherein the main raw materials comprise: calcium carbonate, ferrous gluconate, zinc oxide, main auxiliary material includes: sorbitol and white granulated sugar are combined according to the following percentages: 30 to 40 percent of calcium carbonate, 1 to 2 percent of ferrous gluconate, 0.1 to 0.2 percent of zinc oxide, 30 to 40 percent of sorbitol, 20 to 30 percent of white granulated sugar, 0.2 to 1 percent of acidity regulator, 0.1 to 0.5 percent of sweetening agent and 0.1 to 0.5 percent of flavoring agent.
Further, the acidity regulator is citric acid.
Further, the flavoring agent is edible essence.
The invention also provides a preparation process of the low-iron-rust-taste calcium-iron-zinc chewable tablet, which comprises the following steps:
mixing: uniformly mixing 30-40% of calcium carbonate, 1-2% of ferrous gluconate, 0.1-0.2% of zinc oxide, 30-40% of sorbitol, 20-30% of white granulated sugar, 0.2-1% of citric acid, 0.1-0.5% of sweetening agent and 0.1-0.5% of edible essence to obtain a matrix mixture;
and (3) granulating: crushing the matrix mixture and then carrying out wet granulation to obtain matrix particles;
and (3) drying: drying the matrix particles;
tabletting: compressing the fixed weight of matrix particles into chewable tablets.
Further, the mixing process adopts a three-dimensional motion mixer to mix, and after being mixed uniformly, a sieve with 80 meshes is adopted to filter and discharge.
Further, in the granulating process, 80-90% of matrix mixture and 10-20% of binding agent are added into a high-efficiency wet granulator for granulating.
Further, the binder is ethanol (95%).
Furthermore, the drying process adopts a hot air circulation oven with the temperature of 50-60 ℃ for drying for 2-5 hours to control the moisture of the matrix particles to 0.5% -1%.
Further, 1.5g of the matrix granules were compressed into chewable tablets using a rotary punch press during tabletting.
Compared with the prior art, the invention provides the low-iron-rust-taste calcium-iron-zinc chewable tablet and the preparation method thereof, and the chewable tablet has the following beneficial effects:
1. the invention takes calcium carbonate, ferrous gluconate and zinc oxide as main raw materials and takes sorbitol, white granulated sugar and the like as auxiliary materials, and has novel dosage form, sour and delicious taste and no iron rust taste.
2. The chewable tablet is prepared by the steps of mixing, granulating, drying and tabletting, and has reasonable process, stable product specification and good chewing effect.
Drawings
Fig. 1 is a data diagram of various detection reports of a low-iron-rust-taste calcium-iron-zinc chewable tablet.
Detailed Description
The invention provides a calcium, iron and zinc chewable tablet with low rust taste, which comprises: the main raw materials, main auxiliary materials, an acidity regulator, a sweetening agent and a flavoring agent, wherein the main raw materials comprise: calcium carbonate, ferrous gluconate, zinc oxide, main auxiliary material includes: sorbitol and white granulated sugar are combined according to the following percentages: 30-40% of calcium carbonate, 1-2% of ferrous gluconate, 0.1-0.2% of zinc oxide, 30-40% of sorbitol, 20-30% of white granulated sugar, 0.2-1% of acidity regulator, 0.1-0.5% of sweetening agent and 0.1-0.5% of flavoring agent, wherein the acidity regulator is citric acid and the flavoring agent is edible essence.
The invention provides a preparation process of a low-iron rust flavor calcium, iron and zinc chewable tablet, which comprises the following steps of: uniformly mixing calcium carbonate (30% -40%), ferrous gluconate (1% -2%), zinc oxide (0.1% -0.2%), sorbitol (30% -40%), white granulated sugar (20% -30%), citric acid (0.2% -1%), sweetening agent (0.1% -0.5%) and edible essence (0.1% -0.5%) to obtain a matrix mixture, mixing by using a three-dimensional motion mixer in the mixing process, and filtering and discharging by using an 80-mesh screen after uniform mixing;
and (3) granulating: adding 80-90% of matrix mixture and 10-20% of adhesive into a high-efficiency wet granulator for granulation to obtain matrix particles, adding the matrix particles into a high-efficiency crushing and sizing machine for sizing and filtering, and controlling the size of the matrix particles by using a 16-24-mesh screen on the high-efficiency crushing and sizing machine, wherein the adhesive is ethanol (95%);
and (3) drying: drying the whole base particles, wherein the drying process adopts a hot air circulation oven at 50-60 ℃ for drying for 2-5 hours to control the moisture of the base particles to 0.5% -1%;
tabletting: pressing the matrix particles with fixed weight into chewable tablets, pressing 1.5g of the matrix particles into chewable tablets with hardness of 100N-200N and friability of less than or equal to 0.8% by using a rotary impact tablet press during tabletting, and detecting the chewable tablets every 30min to control the weight difference within +/-5%.
The detection structure shown in figure 1 is obtained by detecting the low-iron rust taste calcium iron zinc chewable tablet prepared by the preparation method and the preparation process thereof, the detection structure shows that all indexes of the product meet the standards, the content of calcium iron zinc meets the standards, and the production process is reasonable, so that various impurities generated in the production process can be avoided, and the taste is delicious.
Finally, it should be noted that: although the present invention and its advantages have been described in detail, it should be understood that various changes, substitutions and alterations can be made herein without departing from the spirit and scope of the invention as defined by the appended claims. Moreover, the scope of the present application is not intended to be limited to the particular embodiments of the process, machine, means, methods and steps described in the specification. As one of ordinary skill in the art will readily appreciate from the disclosure of the present invention, processes, devices, means, methods, or steps, presently existing or later to be developed that perform substantially the same function or achieve substantially the same result as the corresponding embodiments described herein may be utilized according to the present invention. Accordingly, the appended claims are intended to include within their scope such processes, devices, means, methods, or steps.
Claims (9)
1. A calcium, iron and zinc chewable tablet with low rust taste is characterized by comprising the following components: the main raw materials, main auxiliary materials, an acidity regulator, a sweetening agent and a flavoring agent, wherein the main raw materials comprise: calcium carbonate, ferrous gluconate, zinc oxide, main auxiliary material includes: sorbitol and white granulated sugar are combined according to the following percentages: 30 to 40 percent of calcium carbonate, 1 to 2 percent of ferrous gluconate, 0.1 to 0.2 percent of zinc oxide, 30 to 40 percent of sorbitol, 20 to 30 percent of white granulated sugar, 0.2 to 1 percent of acidity regulator, 0.1 to 0.5 percent of sweetening agent and 0.1 to 0.5 percent of flavoring agent.
2. The chewable tablet of calcium, iron and zinc with low rust taste according to claim 1, wherein the acidity regulator is citric acid.
3. The chewable tablet with low iron rust taste according to claim 1, wherein the flavoring agent is a flavoring essence.
4. A preparation process of a low-iron-rust-taste calcium-iron-zinc chewable tablet is characterized by comprising the following steps of:
mixing: uniformly mixing 30-40% of calcium carbonate, 1-2% of ferrous gluconate, 0.1-0.2% of zinc oxide, 30-40% of sorbitol, 20-30% of white granulated sugar, 0.2-1% of citric acid, 0.1-0.5% of sweetening agent and 0.1-0.5% of edible essence to obtain a matrix mixture;
and (3) granulating: carrying out wet granulation on the matrix mixture to obtain matrix particles;
and (3) drying: drying the matrix particles;
tabletting: compressing the fixed weight of matrix particles into chewable tablets.
5. The preparation process of the calcium, iron and zinc chewable tablet with low rust flavor according to claim 4, wherein the mixing process is carried out by a three-dimensional motion mixer, and after the mixing is uniform, an 80-mesh screen is used for filtering and discharging.
6. The process for preparing a calcium iron zinc chewable tablet with low rust flavor according to claim 4, wherein the granulating process comprises adding 80-90% of matrix mixture and 10-20% of binding agent into a high-efficiency wet granulator for granulation.
7. The process for preparing a chewable tablet with low iron rust smell according to claim 6, wherein the binder is ethanol (95%).
8. The preparation process of the calcium, iron and zinc chewable tablet with low rust taste according to claim 4, wherein the drying process adopts a hot air circulation oven at 50-60 ℃ for drying for 2-5 hours to control the moisture of the matrix particles to 0.5-1%.
9. The process for preparing a Ca-Fe-Zn chewable tablet with low iron rust flavor as claimed in claim 4, wherein 1.5g of the matrix granules are compressed into the chewable tablet by a rotary impact tablet press during the tabletting process.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112400993A (en) * | 2020-11-20 | 2021-02-26 | 宣城柏维力生物工程有限公司 | Stomach-protecting probiotic tablet and production process thereof |
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| Title |
|---|
| 宣城柏维力生物工程有限公司: "维益牌钙铁锌咀嚼片", 《安徽省食品安全企业标准备案服务平台--宣城柏维力生物工程有限公司食品安全企业标准》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112400993A (en) * | 2020-11-20 | 2021-02-26 | 宣城柏维力生物工程有限公司 | Stomach-protecting probiotic tablet and production process thereof |
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