CN111920743A - Hydrogen-rich hand washing-free disinfection gel and preparation method thereof - Google Patents
Hydrogen-rich hand washing-free disinfection gel and preparation method thereof Download PDFInfo
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- CN111920743A CN111920743A CN202010993952.3A CN202010993952A CN111920743A CN 111920743 A CN111920743 A CN 111920743A CN 202010993952 A CN202010993952 A CN 202010993952A CN 111920743 A CN111920743 A CN 111920743A
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- 238000004659 sterilization and disinfection Methods 0.000 title claims abstract description 73
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 title claims abstract description 42
- 239000001257 hydrogen Substances 0.000 title claims abstract description 42
- 229910052739 hydrogen Inorganic materials 0.000 title claims abstract description 42
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 238000001879 gelation Methods 0.000 title description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 78
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 26
- 241001116389 Aloe Species 0.000 claims abstract description 24
- 235000011399 aloe vera Nutrition 0.000 claims abstract description 24
- SOQBVABWOPYFQZ-UHFFFAOYSA-N oxygen(2-);titanium(4+) Chemical class [O-2].[O-2].[Ti+4] SOQBVABWOPYFQZ-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 18
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 18
- 239000008367 deionised water Substances 0.000 claims abstract description 17
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 17
- 238000000034 method Methods 0.000 claims abstract description 16
- 239000002562 thickening agent Substances 0.000 claims abstract description 12
- 239000003906 humectant Substances 0.000 claims abstract description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 28
- 238000010257 thawing Methods 0.000 claims description 18
- 108010059892 Cellulase Proteins 0.000 claims description 14
- 108010059820 Polygalacturonase Proteins 0.000 claims description 14
- 229940106157 cellulase Drugs 0.000 claims description 14
- 108010093305 exopolygalacturonase Proteins 0.000 claims description 14
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 12
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical group OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 10
- 238000005516 engineering process Methods 0.000 claims description 10
- 239000000835 fiber Substances 0.000 claims description 10
- 235000011187 glycerol Nutrition 0.000 claims description 10
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 10
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 10
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 10
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical group OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 9
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 8
- 238000010438 heat treatment Methods 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 7
- 239000012528 membrane Substances 0.000 claims description 7
- 239000002994 raw material Substances 0.000 claims description 7
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 6
- 238000007710 freezing Methods 0.000 claims description 6
- 230000008014 freezing Effects 0.000 claims description 6
- 229910052757 nitrogen Inorganic materials 0.000 claims description 6
- 229930003427 Vitamin E Natural products 0.000 claims description 4
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 4
- 238000000265 homogenisation Methods 0.000 claims description 4
- 239000002101 nanobubble Substances 0.000 claims description 4
- 239000011709 vitamin E Substances 0.000 claims description 4
- 235000019165 vitamin E Nutrition 0.000 claims description 4
- 229940046009 vitamin E Drugs 0.000 claims description 4
- 239000004408 titanium dioxide Substances 0.000 claims description 3
- 238000005554 pickling Methods 0.000 claims description 2
- 230000000249 desinfective effect Effects 0.000 claims 2
- 239000003002 pH adjusting agent Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 abstract description 64
- 230000000694 effects Effects 0.000 abstract description 20
- 230000006378 damage Effects 0.000 abstract description 5
- AFHJQYHRLPMKHU-XXWVOBANSA-N Aloin Natural products O=C1c2c(O)cc(CO)cc2[C@H]([C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O2)c2c1c(O)ccc2 AFHJQYHRLPMKHU-XXWVOBANSA-N 0.000 abstract description 2
- 229940069521 aloe extract Drugs 0.000 abstract description 2
- AFHJQYHRLPMKHU-OSYMLPPYSA-N aloin A Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1[C@@H]1C2=CC(CO)=CC(O)=C2C(=O)C2=C(O)C=CC=C21 AFHJQYHRLPMKHU-OSYMLPPYSA-N 0.000 abstract description 2
- 238000003912 environmental pollution Methods 0.000 abstract description 2
- 239000003205 fragrance Substances 0.000 abstract description 2
- AFHJQYHRLPMKHU-UHFFFAOYSA-N isobarbaloin Natural products OC1C(O)C(O)C(CO)OC1C1C2=CC(CO)=CC(O)=C2C(=O)C2=C(O)C=CC=C21 AFHJQYHRLPMKHU-UHFFFAOYSA-N 0.000 abstract description 2
- 230000003020 moisturizing effect Effects 0.000 abstract description 2
- 235000019441 ethanol Nutrition 0.000 description 24
- 230000001954 sterilising effect Effects 0.000 description 10
- LLEMOWNGBBNAJR-UHFFFAOYSA-N biphenyl-2-ol Chemical compound OC1=CC=CC=C1C1=CC=CC=C1 LLEMOWNGBBNAJR-UHFFFAOYSA-N 0.000 description 8
- 230000006872 improvement Effects 0.000 description 8
- 230000009471 action Effects 0.000 description 6
- 238000009987 spinning Methods 0.000 description 6
- 244000052616 bacterial pathogen Species 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 5
- 239000000645 desinfectant Substances 0.000 description 5
- 235000010292 orthophenyl phenol Nutrition 0.000 description 4
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 4
- 230000002147 killing effect Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000002243 precursor Substances 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 230000002195 synergetic effect Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 238000010041 electrostatic spinning Methods 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
- 239000000344 soap Substances 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- HODBJNPCEPMORW-UHFFFAOYSA-N 2,4,5-trichloro-3-phenoxyphenol Chemical compound OC1=CC(Cl)=C(Cl)C(OC=2C=CC=CC=2)=C1Cl HODBJNPCEPMORW-UHFFFAOYSA-N 0.000 description 1
- WXHLLJAMBQLULT-UHFFFAOYSA-N 2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-n-(2-methyl-6-sulfanylphenyl)-1,3-thiazole-5-carboxamide;hydrate Chemical compound O.C=1C(N2CCN(CCO)CC2)=NC(C)=NC=1NC(S1)=NC=C1C(=O)NC1=C(C)C=CC=C1S WXHLLJAMBQLULT-UHFFFAOYSA-N 0.000 description 1
- 241000197194 Bulla Species 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 206010033733 Papule Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
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- 230000003471 anti-radiation Effects 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 208000002352 blister Diseases 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
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- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 238000003760 magnetic stirring Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000013557 residual solvent Substances 0.000 description 1
- 238000011076 safety test Methods 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
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- 230000001550 time effect Effects 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8129—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers or esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers, e.g. polyvinylmethylether
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
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- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Dispersion Chemistry (AREA)
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- Cosmetics (AREA)
Abstract
The invention discloses a hydrogen-rich hand washing-free disinfection gel and a preparation method thereof, and relates to the technical field of disinfection gels, wherein the gel comprises the following components in parts by weight: 10-15 parts of aloe, 10-15 parts of a thickening agent, 50-80 parts of polyvinyl alcohol, 70-90 parts of ethanol, 15-30 parts of a humectant, 8-18 parts of a pH regulator, 5-10 parts of modified nano titanium dioxide and 30-50 parts of deionized water. The aloe extract has moisturizing and water locking effects, and can reduce skin water loss by slight film forming effect. The method for extracting aloe by enzymolysis reduces damage to heat sensitive components such as barbaloin, retains color and fragrance of aloe gel, and reduces environmental pollution.
Description
Technical Field
The invention relates to the technical field of disinfection gel, in particular to hydrogen-rich hand washing-free disinfection gel and a preparation method thereof.
Background
Nowadays, the hand washing-free disinfection gel advocates 'saving water resource' and 'protecting environment' in the whole society, and helps people to save precious water resource and beautify our environment at any time and any place while ensuring health, and the hand washing-free disinfection gel does not need to use towels, water, soaps and the like. The hand washing-free disinfection gel is suitable for being used for washing-free hand washing-free disinfection in the environments without water sources and soaps, such as hospitals, banks, supermarkets, offices, enterprises and public institutions, movie theaters, armies, entertainment venues, schools, kindergartens, families, hotels, restaurants, airports, docks, railway stations, tourist attractions and the like, and is more convenient to use. In recent years, no-clean hand disinfection gel has gradually received people's acceptance and is increasingly present in daily necessities of people. Although the hand washing-free disinfection gel has the advantages of convenient use and portability, the existing product still has certain defects.
If the components of the hand washing-free disinfection gel and the proportion of the components are selected unreasonably, the problems of unsatisfactory sterilization effect, great damage to skin, damage to human health by the disinfectant or high production cost and the like can occur. In the prior art, the invention patent with application publication number CN101953779A discloses a medical disinfection gel, which is composed of o-phenylphenol, ethanol, a thickening agent, a humectant, a pH regulator and deionized water, and the medical disinfection gel comprises the following components in percentage by mass: 1.0-5.0% of o-phenylphenol, 55-65% of ethanol, 1.0-5.0% of thickening agent, 3.0-8.0% of humectant, 1.0-3.0% of pH regulator and the balance of deionized water. The main effective component of the medical disinfection gel is o-phenylphenol, ethanol has a synergistic effect, and the o-phenylphenol has a carcinogenic effect, so the medical disinfection gel has certain side effects. The invention patent with application publication number CN107669619A discloses a hand-washing-free disinfection gel and a preparation method thereof, wherein the hand-washing-free disinfection gel comprises the following components in parts by weight: 45-78 parts of ethanol, 7-15 parts of n-propyl alcohol, 0.02-0.08 part of dichlorophenoxy chlorophenol, 16-40 parts of deionized water, 0.2-0.8 part of thickening agent and 0.3-1.1 part of neutralizing agent. The triclosan in the hand-washing-free disinfection gel also has toxic and side effects. The sterilization part of most of the no-clean hand washing liquids has the problems of weak sterilization effect or large irritation to hand skin caused by chemical components, short time-effect, and side effect reaction such as skin irritation and allergy.
Therefore, how to achieve the purposes of reducing the side effect of the disinfectant while achieving high sterilization rate and simultaneously ensuring that the skin care effect is good and the action time is long when the disinfectant is used by consumers is a problem to be solved urgently.
Disclosure of Invention
The invention aims to provide hydrogen-rich hand washing-free disinfection gel with disinfection and sterilization effects, so as to improve the action time and skin care effect of the hydrogen-rich hand washing-free disinfection gel.
In order to achieve the purpose, the invention provides the following scheme:
the invention provides hydrogen-rich hand washing-free disinfection gel which comprises the following raw materials in parts by weight: 10-15 parts of aloe, 10-15 parts of a thickening agent, 50-80 parts of polyvinyl alcohol, 70-90 parts of ethanol, 15-30 parts of a humectant, 8-18 parts of a pH regulator, 5-10 parts of modified nano titanium dioxide and 30-50 parts of deionized water.
As a further improvement of the invention, the raw materials comprise the following components in parts by weight: 12-15 parts of aloe, 12-15 parts of a thickening agent, 60-70 parts of polyvinyl alcohol, 80-85 parts of ethanol, 25-30 parts of a humectant, 12-15 parts of a pH regulator, 7-10 parts of modified nano titanium dioxide and 40-45 parts of deionized water.
As a further improvement of the invention, the thickener is hydroxypropyl methylcellulose.
As a further improvement of the invention, the humectant is glycerin or vitamin E.
As a further improvement of the invention, the pH regulator is triethanolamine.
As a further improvement of the invention, the preparation method of the modified nano titanium dioxide comprises the following steps: preparing a titanium dioxide fiber membrane, pickling and crushing to obtain the modified nano titanium dioxide.
The invention also provides a preparation method of the hydrogen-rich hand washing-free disinfection gel, which comprises the following steps:
(1) adding pectinase and cellulase into aloe for enzymolysis, wherein the pH value of enzymolysis is 3-5, the enzymolysis temperature is 35-40 ℃, and the enzymolysis time is 1-3 h, so as to obtain an enzymolysis product;
(2) mixing the enzymolysis product with a thickening agent, polyvinyl alcohol and ethanol, uniformly stirring, freezing for 10-15 min under the condition of liquid nitrogen, and then thawing to obtain a thawing solution;
(3) adding a humectant, a pH regulator, modified nano titanium dioxide and deionized water into the thawing solution, heating, and naturally cooling to room temperature to obtain hand washing-free disinfection gel;
(4) and (4) adding compressed hydrogen into the hand washing-free disinfection gel obtained in the step (3) by a micro-nano bubble method to obtain hydrogen-rich hand washing-free disinfection gel.
As a further improvement of the invention, the step (3) is heated to 45-65 ℃.
As a further improvement of the invention, the micro-nano bubble method adopts at least one of a homogenization technology, an ultrasonic technology and a pressure difference technology.
The invention discloses the following technical effects:
the no-clean hand sanitizer has the advantages of convenience in use and carrying of the existing product, and simultaneously has the effect of safely and effectively inhibiting and killing pathogenic bacteria while effectively cleaning the skin of hands. The hydrogen-rich hand washing-free disinfection gel uses ethanol and polyvinyl alcohol as disinfectants and solvents, a small amount of ethanol and polyvinyl alcohol are attached to the skin, so that the gel has no toxic or side effect on the human body, does not cause harm to the body of a user, and is quick in ethanol volatilization and not easy to remain on the hands. Ethanol can inhibit gram-negative bacteria, gram-positive bacteria, envelope virus and various fungi activity, and kill bacteria propagules. After the ethanol, the polyvinyl alcohol and the modified nano titanium dioxide are compounded, the sterilizing gel has a synergistic effect, a good sterilizing effect and a long acting time, and the modified nano titanium dioxide can absorb ultraviolet rays, so that the sterilizing gel has an anti-radiation function. The thickening agent and the pH regulator used in the disinfection gel can obtain stable hand disinfection gel, so that the ethanol disinfectant in the disinfection gel is distributed more uniformly, and the overall sterilization and disinfection effect of the disinfection gel is better. The disinfection gel provided by the invention is added with aloe, glycerol and vitamin E, so that the irritation of ethanol to human skin can be relieved, and the disinfection gel has a lubricating effect. The aloe extract has moisturizing and water locking effects, and can reduce skin water loss by slight film forming effect. The method for extracting aloe by enzymolysis reduces damage to heat sensitive components such as barbaloin, retains color and fragrance of aloe gel, and reduces environmental pollution.
Detailed Description
Reference will now be made in detail to various exemplary embodiments of the invention, the detailed description should not be construed as limiting the invention but as a more detailed description of certain aspects, features and embodiments of the invention.
It is to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. Further, for numerical ranges in this disclosure, it is understood that each intervening value, between the upper and lower limit of that range, is also specifically disclosed. Every smaller range between any stated value or intervening value in a stated range and any other stated or intervening value in a stated range is encompassed within the invention. The upper and lower limits of these smaller ranges may independently be included or excluded in the range.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although only preferred methods and materials are described herein, any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention. All documents mentioned in this specification are incorporated by reference herein for the purpose of disclosing and describing the methods and/or materials associated with the documents. In case of conflict with any incorporated document, the present specification will control.
It will be apparent to those skilled in the art that various modifications and variations can be made in the specific embodiments of the present disclosure without departing from the scope or spirit of the disclosure. Other embodiments will be apparent to those skilled in the art from consideration of the specification. The description and examples are intended to be illustrative only.
As used herein, the terms "comprising," "including," "having," "containing," and the like are open-ended terms that mean including, but not limited to.
In the present invention, "parts" are parts by mass unless otherwise specified.
The homogenization technique, the ultrasonic technique, and the pressure difference technique described in the embodiments of the present invention are all conventional techniques, and are not described herein.
The preparation method of the modified nano titanium dioxide comprises the following steps: adding 3.4g of n-butyl titanate and 2g of sulfosalicylic acid into 9ml of absolute ethyl alcohol, and magnetically stirring for 1 hour to obtain a suspension A; adding 3.5g of polyvinylpyrrolidone into 9ml of absolute ethyl alcohol, and uniformly mixing by magnetic stirring for 2 hours to obtain a solution B; mixing the suspension A and the solution B, magnetically stirring for 40 minutes, ultrasonically vibrating for 10 minutes, magnetically stirring again for 30 minutes after ultrasonic vibration, and then ultrasonically vibrating again for 10 minutes to obtain uniform suspension as a spinning precursor solution; adding the spinning precursor solution into a solution storage mechanism of an electrostatic spinning device, connecting a spinning spray head with a high-voltage power supply anode, connecting a collector with a high-voltage power supply cathode, adjusting spinning voltage and spinning distance to carry out electrostatic spinning, and forming a fiber film on the collector by the spinning precursor solution under the action of electric field force to obtain a titanium dioxide fiber film (a prepared fiber film); the preparation fiber membrane is subjected to high-temperature heat treatment in an anoxic environment to remove high molecular polymers and residual solvents in the preparation fiber membrane, the preparation fiber membrane is soaked in hydrochloric acid for 10 hours at a constant temperature of 50 ℃, and is repeatedly washed with water until the preparation fiber membrane is neutral, and then the preparation fiber membrane is crushed to obtain the modified nano titanium dioxide.
Example 1
The hydrogen-rich hand washing-free disinfection gel comprises the following raw materials in parts by weight: 10 parts of aloe, 15 parts of hydroxypropyl methyl cellulose, 55 parts of polyvinyl alcohol, 75 parts of ethanol, 20 parts of glycerol, 10 parts of triethanolamine, 5 parts of modified nano titanium dioxide and 30 parts of deionized water.
The preparation method of the hydrogen-rich hand washing-free disinfection gel comprises the following steps: (1) adding pectinase and cellulase into aloe for enzymolysis, wherein the mass ratio of the total mass of the pectinase and the cellulase to the aloe is 5: 1, the mass ratio of the pectinase to the cellulase is 1: 1, carrying out enzymolysis at the pH value of 3 and the temperature of 35 ℃ for 1h to obtain an enzymolysis product;
(2) mixing the enzymolysis product with hydroxypropyl methylcellulose, polyvinyl alcohol and ethanol, stirring uniformly, freezing for 10min under the condition of liquid nitrogen, and then thawing to obtain a thawing solution;
(3) adding glycerol, triethanolamine, modified nano titanium dioxide and deionized water into the thawing solution, heating to 45 ℃, and naturally cooling to room temperature to obtain hand washing-free disinfection gel;
(4) adding compressed hydrogen into the hand washing-free disinfection gel obtained in the step (3) by an ultrasonic technology to obtain hydrogen-rich hand washing-free disinfection gel.
Example 2
The hydrogen-rich hand washing-free disinfection gel comprises the following raw materials in parts by weight: 15 parts of aloe, 12 parts of hydroxypropyl methyl cellulose, 80 parts of polyvinyl alcohol, 90 parts of ethanol, 15 parts of glycerol, 8 parts of triethanolamine, 8 parts of modified nano titanium dioxide and 40 parts of deionized water.
The preparation method of the hydrogen-rich hand washing-free disinfection gel comprises the following steps: (1) adding pectinase and cellulase into aloe for enzymolysis, wherein the mass ratio of the total mass of the pectinase and the cellulase to the aloe is 5: 1, the mass ratio of the pectinase to the cellulase is 1: 1, carrying out enzymolysis at the pH value of 5 and the temperature of 35 ℃ for 1h to obtain an enzymolysis product;
(2) mixing the enzymolysis product with hydroxypropyl methylcellulose, polyvinyl alcohol and ethanol, stirring uniformly, freezing for 10min under the condition of liquid nitrogen, and then thawing to obtain a thawing solution;
(3) adding glycerol, triethanolamine, modified nano titanium dioxide and deionized water into the thawing solution, heating to 45 ℃, and naturally cooling to room temperature to obtain hand washing-free disinfection gel;
(4) adding compressed hydrogen into the hand washing-free disinfection gel obtained in the step (3) by a homogenization technology to obtain hydrogen-rich hand washing-free disinfection gel.
Example 3
The hydrogen-rich hand washing-free disinfection gel comprises the following raw materials in parts by weight: 15 parts of aloe, 12 parts of hydroxypropyl methyl cellulose, 80 parts of polyvinyl alcohol, 90 parts of ethanol, 15 parts of glycerol, 8 parts of triethanolamine, 8 parts of modified nano titanium dioxide and 40 parts of deionized water.
The preparation method of the hydrogen-rich hand washing-free disinfection gel comprises the following steps: (1) adding pectinase and cellulase into aloe for enzymolysis, wherein the mass ratio of the total mass of the pectinase and the cellulase to the aloe is 5: 1, the mass ratio of the pectinase to the cellulase is 1: 1, carrying out enzymolysis at the pH value of 4 and the enzymolysis temperature of 40 ℃ for 3h to obtain an enzymolysis product;
(2) mixing the enzymolysis product with hydroxypropyl methylcellulose, polyvinyl alcohol and ethanol, stirring uniformly, freezing for 12min under the condition of liquid nitrogen, and then thawing to obtain a thawing solution;
(3) adding glycerol, triethanolamine, modified nano titanium dioxide and deionized water into the thawing solution, heating to 50 ℃, and naturally cooling to room temperature to obtain hand washing-free disinfection gel;
(4) adding compressed hydrogen into the hand washing-free disinfection gel obtained in the step (3) by an ultrasonic technology to obtain hydrogen-rich hand washing-free disinfection gel.
Example 4
The hydrogen-rich hand washing-free disinfection gel comprises the following raw materials in parts by weight: 12 parts of aloe, 10 parts of hydroxypropyl methyl cellulose, 50 parts of polyvinyl alcohol, 70 parts of ethanol, 30 parts of vitamin E, 18 parts of triethanolamine, 10 parts of modified nano titanium dioxide and 50 parts of deionized water.
The preparation method of the hydrogen-rich hand washing-free disinfection gel comprises the following steps: (1) adding pectinase and cellulase into aloe for enzymolysis, wherein the mass ratio of the total mass of the pectinase and the cellulase to the aloe is 5: 1, the mass ratio of the pectinase to the cellulase is 1: 1, carrying out enzymolysis at the pH value of 4 and the temperature of 38 ℃ for 2h to obtain an enzymolysis product;
(2) mixing the enzymolysis product with hydroxypropyl methylcellulose, polyvinyl alcohol and ethanol, stirring uniformly, freezing for 15min under the condition of liquid nitrogen, and then thawing to obtain a thawing solution;
(3) adding glycerol, triethanolamine, modified nano titanium dioxide and deionized water into the thawing solution, heating to 65 ℃, and naturally cooling to room temperature to obtain hand washing-free disinfection gel;
(4) adding compressed hydrogen into the hand washing-free disinfection gel obtained in the step (3) by an ultrasonic technology to obtain hydrogen-rich hand washing-free disinfection gel.
Comparative example 1
The difference is that the modified nano titanium dioxide is not added, as in example 1.
Comparative example 2
The only difference from example 1 is that no polyallyl alcohol was added.
Comparative example 3
The difference from example 1 is only that aloe was added and no enzymatic treatment was performed.
Product safety detection test:
the safety of the Chinese herbal medicine ingredient no-wash hand gels of examples 1-4 of the present invention was tested using a skin patch, and the test results are shown in table 1.
TABLE 1
| Safety test results | |
| Example 1 | - |
| Example 2 | - |
| Example 3 | - |
| Example 4 | - |
Negative (-) by: the application part has no reaction or only the sticking part of the adhesive plaster turns red.
(+) weak positive: erythema, infiltrates, papules, small blisters.
(++) mid-positive: scattered in the pimple and obvious in pruritus.
Strong positive (+++): red and swollen with bulla.
As can be seen from the results in Table 1, the hydrogen-rich hand washing-free disinfection gel prepared by the invention is mild and non-irritant to skin and is safe to use.
The product has the following effects:
the sterilization rate and the bacteriostasis rate of the hydrogen-rich hand-free disinfection gel of the embodiments 1-4 of the invention to pathogenic bacteria with different action time are shown in the table 2, and the sterilization rate and the bacteriostasis rate of the hydrogen-rich hand-free disinfection gel of the comparative examples 1-3 to pathogenic bacteria with different action time are shown in the table 3.
TABLE 2
TABLE 3
The hydrogen-rich hand washing-free disinfection gel prepared by the invention has good state, and does not drip during the experiment process. As can be seen from the data in tables 2 and 3, the hydrogen-rich hand washing-free disinfection gel prepared by the invention has good killing effect and bacteriostasis effect on pathogenic bacteria in a short time, can realize quick and effective killing of the pathogenic bacteria, and has broad bactericidal spectrum. It can be seen from the example 1 and the comparative example 1 that the ethanol, the polyvinyl alcohol and the modified nano titanium dioxide have synergistic effect after being compounded, the action time is prolonged, and the bacteriostatic and bactericidal effects are enhanced.
The above-described embodiments are merely illustrative of the preferred embodiments of the present invention, and do not limit the scope of the present invention, and various modifications and improvements of the technical solutions of the present invention can be made by those skilled in the art without departing from the spirit of the present invention, and the technical solutions of the present invention are within the scope of the present invention defined by the claims.
Claims (8)
1. The hydrogen-rich hand washing-free disinfection gel is characterized by comprising the following raw materials in parts by weight: 10-15 parts of aloe, 10-15 parts of a thickening agent, 50-80 parts of polyvinyl alcohol, 70-90 parts of ethanol, 15-30 parts of a humectant, 8-18 parts of a pH regulator, 5-10 parts of modified nano titanium dioxide and 30-50 parts of deionized water.
2. The hydrogen rich hand sanitizer gel according to claim 1, wherein the thickener is hydroxypropylmethylcellulose.
3. The hydrogen-rich hand sanitizer gel according to claim 1, wherein the humectant is glycerin or vitamin E.
4. The hydrogen-rich hand sanitizer gel according to claim 1, wherein the pH adjuster is triethanolamine.
5. The hydrogen-rich hand washing-free disinfecting gel as claimed in claim 1, wherein the preparation method of the modified nano titanium dioxide comprises the following steps: preparing a titanium dioxide fiber membrane, pickling and crushing to obtain the modified nano titanium dioxide.
6. A method of preparing a hydrogen rich hand sanitizer gel according to any one of claims 1 to 5, comprising the steps of:
(1) adding pectinase and cellulase into aloe for enzymolysis, wherein the pH value of enzymolysis is 3-5, the enzymolysis temperature is 35-40 ℃, and the enzymolysis time is 1-3 h, so as to obtain an enzymolysis product;
(2) mixing the enzymolysis product with a thickening agent, polyvinyl alcohol and ethanol, uniformly stirring, freezing for 10-15 min under the condition of liquid nitrogen, and then thawing to obtain a thawing solution;
(3) adding a humectant, a pH regulator, modified nano titanium dioxide and deionized water into the thawing solution, heating, and naturally cooling to room temperature to obtain hand washing-free disinfection gel;
(4) and (4) adding compressed hydrogen into the hand washing-free disinfection gel obtained in the step (3) by a micro-nano bubble method to obtain hydrogen-rich hand washing-free disinfection gel.
7. The method for preparing hydrogen-rich hand-washing-free disinfecting gel according to claim 6, wherein the step (3) is heating to 45-65 ℃.
8. The method for preparing hydrogen-rich hand-washing-free disinfection gel according to claim 6, wherein the micro-nano bubble method adopts at least one of homogenization technology, ultrasonic technology and pressure difference technology.
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1121109A (en) * | 1994-10-19 | 1996-04-24 | 韩兵 | Water-less and soap-less hand-cleaning liquid |
| CN106580817A (en) * | 2016-11-29 | 2017-04-26 | 青岛海之星生物科技有限公司 | Antibacterial hand sanitizer based on titanium dioxide/activated carbon composite material |
| CN107157889A (en) * | 2017-06-20 | 2017-09-15 | 南京福特卡特材料科技有限公司 | A kind of soft hand cleanser and preparation method thereof |
| CN109498732A (en) * | 2018-11-26 | 2019-03-22 | 郑州吉尔康消毒制品有限公司 | Hand-wrist bones gel and preparation method thereof |
| CN110384621A (en) * | 2019-07-04 | 2019-10-29 | 杭州氢源素生物科技有限公司 | A kind of disposable hand-wrist bones gel of hydrogen-rich and preparation method thereof |
| CN111053707A (en) * | 2020-03-16 | 2020-04-24 | 广州康健医学科技有限公司 | Liquid film protective agent for disinfection protection and preparation method and application thereof |
-
2020
- 2020-09-21 CN CN202010993952.3A patent/CN111920743A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1121109A (en) * | 1994-10-19 | 1996-04-24 | 韩兵 | Water-less and soap-less hand-cleaning liquid |
| CN106580817A (en) * | 2016-11-29 | 2017-04-26 | 青岛海之星生物科技有限公司 | Antibacterial hand sanitizer based on titanium dioxide/activated carbon composite material |
| CN107157889A (en) * | 2017-06-20 | 2017-09-15 | 南京福特卡特材料科技有限公司 | A kind of soft hand cleanser and preparation method thereof |
| CN109498732A (en) * | 2018-11-26 | 2019-03-22 | 郑州吉尔康消毒制品有限公司 | Hand-wrist bones gel and preparation method thereof |
| CN110384621A (en) * | 2019-07-04 | 2019-10-29 | 杭州氢源素生物科技有限公司 | A kind of disposable hand-wrist bones gel of hydrogen-rich and preparation method thereof |
| CN111053707A (en) * | 2020-03-16 | 2020-04-24 | 广州康健医学科技有限公司 | Liquid film protective agent for disinfection protection and preparation method and application thereof |
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Application publication date: 20201113 |