CN111905091A - Traditional Chinese medicine composition for treating non-lactation mastitis, traditional Chinese medicine external patch and preparation method - Google Patents

Traditional Chinese medicine composition for treating non-lactation mastitis, traditional Chinese medicine external patch and preparation method Download PDF

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CN111905091A
CN111905091A CN202010928140.0A CN202010928140A CN111905091A CN 111905091 A CN111905091 A CN 111905091A CN 202010928140 A CN202010928140 A CN 202010928140A CN 111905091 A CN111905091 A CN 111905091A
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chinese medicine
traditional chinese
root
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patch
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胡金辉
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First Hospitalof Hunan University Of Chinese Medicine
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Abstract

The invention relates to a traditional Chinese medicine composition for treating non-lactation mastitis, a traditional Chinese medicine external patch and a preparation method. The traditional Chinese medicine composition takes burdock, white impatiens stalk and rhubarb which have the functions of detoxifying and resolving masses as monarch drugs; herba schizonepetae, dried orange peel, cablin potchouli herb, teasel root, deerhorn glue, ginger carbon and prepared rhizome of rehmannia which have the functions of warming yang, reducing phlegm and dredging collaterals are taken as ministerial drugs; the Chinese angelica, the ligusticum wallichii, the cinnamon, the cassia twig, the red paeony root, the angelica dahurica, the bletilla, the cynanchum atratum, the raw aconite, the trogopterus dung and the musk have the effects of activating blood circulation, promoting qi circulation and removing blood stasis, the prepared radix aconiti, the prepared kusnezoff monkshood root, the stiff silkworm, the frankincense, the myrrh, the earthworm and the elecampane have obvious analgesic effect and are used as adjuvant drugs, so the combined Chinese medicinal composition has the effects of warming channels and yang, promoting qi circulation and activating blood, expelling wind and removing cold, reducing phlegm and dredging collaterals, and can. The traditional Chinese medicine composition provided by the application has the advantages of definite and safe curative effect, no toxic or side effect, convenience in carrying and capability of effectively reducing the anaphylactic reaction of a patient.

Description

Traditional Chinese medicine composition for treating non-lactation mastitis, traditional Chinese medicine external patch and preparation method
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating non-lactation mastitis, a traditional Chinese medicine externally-applied patch and a preparation method.
Background
Non-lactation mastitis is an inflammatory disease that occurs in non-lactation women, and can occur in infants, juveniles, middle aged and elderly people. Non-lactation mastitis mainly comprises sudden mass and swelling pain of an affected part at the initial stage, mass suppuration at the middle stage, pus rupture at the later stage and pus outflow to form a fistula, and even breast resection is needed in severe cases, so that serious wound is brought to the mind and body of a patient. Non-lactation mastitis has the characteristics of prolonged course of disease and easy recurrence, and is a chronic inflammatory disease.
Currently, the primary treatment modalities for non-lactating mastitis include hormonal therapy, anti-tubercular therapy, immunotherapy and surgical therapy. However, antibiotic resistance and immunosuppression, hormone-induced homotype obesity and metabolic disorders have presented great difficulties in the treatment of disease. At present, the traditional Chinese medicine oral administration is combined with external application medicine for treating the disease, the curative effect is definite, and the toxic and side effect is small. Most of the Chinese medical scientists think that the pathogenesis of non-lactation mastitis is mainly yang deficiency and phlegm coagulation. Therefore, the treatment methods of warming channels and yang, promoting qi and blood circulation, expelling wind and cold, resolving phlegm and dredging collaterals are needed.
The yang harmonizing ointment is a classic ancient prescription for treating yang deficiency and cold coagulation type pyocutaneous disease, has the effects of warming channels and yang, promoting qi and blood circulation, expelling wind and cold, eliminating phlegm and dredging collaterals, and is used for treating non-lactation mastitis. However, the preparation and use of yang harmonizing ointment are inconvenient, require assistance of doctors, easily contaminate clothes, are inconvenient to carry, and have high probability of anaphylactic reaction.
Disclosure of Invention
The invention provides a traditional Chinese medicine composition for treating non-lactation mastitis, a traditional Chinese medicine external patch and a preparation method, and aims to solve the problems of high probability of anaphylactic reaction and inconvenience in carrying and use in non-lactation mastitis treatment.
The invention provides a traditional Chinese medicine composition for treating non-lactation mastitis, which is prepared from raw materials of burdock, ligusticum wallichii, rheum officinale, angelica sinensis, radix aconiti preparata, radix aconiti kusnezoffii preparata, stiff silkworm, cinnamon, cassia twig, red paeony root, radix angelicae, cynanchum atratum, rhizoma bletillae, frankincense, myrrh, schizonepeta, dried orange peel, patchouli, teasel root, saussurea lappa, earthworm, unprocessed monkshood, clematis root, trogopterus dung, musk, deerhorn glue, ginger carbon and prepared rhizome of rehmannia. The medicine properties of the preparation raw materials are as follows:
and (3) burdock: the traditional Chinese medicine is pungent and bitter in taste and cold in nature, has the effects of dispelling wind and heat, ventilating lung and relieving sore throat, detoxifying and promoting eruption, and reducing swelling and treating sore, and is mainly used for treating wind and heat type common cold, early epidemic febrile disease, measles without adequate eruption, carbuncle and sore.
Ligusticum wallichii: has pungent and warm nature, has effects of activating qi-flowing, resolving stagnation, dispelling pathogenic wind, dryness and dampness, promoting blood circulation and relieving pain, and can be used for treating wind-cooling headache, dizziness, hypochondriac pain, abdominal pain, cold arthralgia, spasm of tendons, amenorrhea, dystocia, puerperal blood stasis, pain, carbuncle, ulcer, and skin and external diseases.
Rhubarb: bitter taste and cold nature; has the effects of purging heat toxin, removing food stagnation and removing blood stasis, and is mainly used for treating excessive heat constipation, delirium and head set, food stagnation and fullness, dysentery with early stage, tenesmus, stasis and amenorrhea, abdominal mass accumulation, seasonal heat epidemic, acute red eye and pain, hematemesis, epistaxis, yang yellow, edema, stranguria with turbid urine, urine also, carbuncle and ulcer pyogenic infections, furuncle and hot water injury. Purge heat and unblock intestines, cool blood and remove toxicity, dispel stasis and dredge meridians.
Chinese angelica: sweet and pungent in flavor and warm in nature, has the effects of replenishing blood and activating blood, regulating menstruation and relieving pain, and loosening the bowel to relieve constipation, and is mainly used for treating blood deficiency and chlorosis, dizziness and palpitation, irregular menstruation, amenorrhea and dysmenorrhea, deficiency cold and abdominal pain, rheumatic arthralgia, traumatic injury, carbuncle, cellulitis, pyocutaneous disease, and constipation due to intestinal dryness.
Radix aconiti preparata: is pungent, bitter and hot in taste, has the effects of dispelling pathogenic wind, removing dampness, warming channels and relieving pain, and is mainly used for treating arthralgia due to wind-cold-dampness, joint psychroalgia, cold hernia pain, anesthesia and pain relieving.
Preparing kusnezoff monkshood root: is pungent, bitter and hot in taste, has the effects of dispelling wind, eliminating dampness, warming channels and relieving pain, and is mainly used for treating wind-cold-dampness arthralgia, cool pain of heart and abdomen, and cold hernia and relieving pain.
Stiff silkworm: salty and pungent in taste, neutral in nature, has effects of calming endogenous wind, relieving spasm, dispelling pathogenic wind, relieving pain, eliminating phlegm and resolving hard mass, and can be used for treating liver wind phlegm, convulsive epilepsy, convulsion, infantile convulsion, tetanus, and apoplexy
Figure BDA0002669186850000021
Headache due to wind-heat, conjunctival congestion, pharyngalgia, pruritus due to rubella, and parotitis.
Cinnamon: the traditional Chinese medicine composition has pungent and sweet taste and strong heat property, has the effects of tonifying fire and supporting yang, guiding fire to return to original, dispelling cold and relieving pain, and warming and dredging channels and collaterals, and is mainly used for treating impotence and cold womb, cold pain in waist and knees, asthma due to kidney deficiency, floating of deficiency yang, dizziness and conjunctival congestion, cold pain in heart and abdomen, vomiting and diarrhea due to deficiency cold, abdominal pain due to cold hernia, dysmenorrhea and amenorrhea.
Cassia twig: has pungent and sweet taste and warm nature, has effects of inducing sweat, relieving exterior syndrome, dispelling cold, relieving pain, activating yang and regulating qi-flowing, and can be used for treating common cold due to wind-cold, pain due to congealing cold and blood stagnation, phlegm and fluid retention, water retention syndrome and cardiopalmus.
Red peony root: is bitter in taste and slightly cold in nature, has the effects of clearing heat and cooling blood, and removing blood stasis and relieving pain, and is mainly used for treating heat entering nutrient-blood, warm toxicity and macula, hematemesis and epistaxis, conjunctival congestion and swelling pain, liver depression and hypochondriac pain, amenorrhea and dysmenorrhea, addiction to abdominal pain, traumatic injury, carbuncle, swelling and sore and ulcer.
Radix angelicae: pungent taste and warm nature; has effects of relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, dredging nasal orifice, eliminating dampness, relieving leukorrhagia, relieving swelling, expelling pus, dispelling pathogenic wind and relieving itching, and can be used for treating wind-cold type common cold, headache, toothache, rheumatalgia, nasosinusitis, leukorrhagia, skin sore, carbuncle and toxic swelling.
Radix cynanchi atrati: the traditional Chinese medicine is bitter and salty in taste and cold in nature, has the effects of clearing heat and cooling blood, inducing diuresis and treating stranguria, detoxifying and treating sores, and is mainly used for treating nutritional heat injury caused by warm pathogen, yin deficiency fever, bone steaming and fatigue heat, postpartum blood deficiency fever, heat stranguria, blood stranguria, carbuncle abscess and pyogenic infections and knife wound.
And (3) common bletilla pseudobulb: is bitter, sweet and astringent in taste and slightly cold in nature, has the effects of astringing to stop bleeding, reducing swelling and promoting granulation, and is mainly used for treating hemoptysis, hematemesis, traumatic hemorrhage, pyocutaneous disease, pyogenic infection and chapped skin.
Frankincense: has pungent and bitter taste and warm nature, has the effects of promoting blood circulation, promoting qi circulation, relieving pain, eliminating swelling and promoting granulation, and is mainly used for treating thoracic obstruction, cardialgia, epigastric pain, dysmenorrhea, amenorrhea, postpartum blood stasis, abdominal pain, rheumatalgia, muscular contracture, traumatic injury, carbuncle, swelling, sore and ulcer.
Myrrh: has pungent, bitter and neutral taste, has the effects of removing blood stasis and relieving pain, and detumescence and promoting granulation, and is mainly used for treating thoracic obstruction and heart pain, epigastric pain, dysmenorrhea and amenorrhea, postpartum stasis, abdominal mass and pain, rheumatic arthralgia, traumatic injury, carbuncle swelling and sore and ulcer, and the like.
Herba schizonepetae: has pungent and mild nature, has effects of relieving exterior syndrome, dispelling pathogenic wind, promoting eruption, and eliminating sore, and can be used for treating common cold, headache, measles, rubella, and initial stage of pyocutaneous disease.
Dried orange peel: bitter and pungent taste, warm in nature; has the effects of regulating qi, invigorating spleen, eliminating dampness and phlegm, and can be used for treating abdominal distention, anorexia, vomiting, diarrhea, cough and excessive phlegm.
Patchouli: pungent in flavor and slightly warm in nature, has the effects of eliminating turbid pathogen with aromatics, regulating the middle warmer, relieving vomiting and relieving summer-heat, and is mainly used for treating damp turbidity obstruction in the middle warmer, epigastric fullness and vomiting, summer-heat and dampness exterior syndrome, early stage of damp-warm syndrome, fever and lassitude, chest distress and discomfort, cold-dampness and summer-heat retention, abdominal pain, vomiting and diarrhea, nasosinusitis and headache.
Teasel root: has mild warm nature and bitter and pungent taste, has effects of nourishing liver and kidney, strengthening tendons and bones, treating fracture, and preventing metrorrhagia and metrostaxis, and is mainly used for treating liver and kidney deficiency, soreness and weakness of waist and knees, rheumatalgia, tendon injury fracture, metrorrhagia and metrostaxis, fetal leakage, traumatic injury, etc.
Radix aucklandiae: is pungent and bitter in taste and warm in nature, has the effects of promoting qi circulation, relieving pain, warming the middle-jiao and regulating the stomach, and is mainly used for treating chest and abdomen distending pain, emesis, diarrhea and dysentery with tenesmus.
Earthworm: has effects of clearing heat, arresting convulsion, dredging collaterals, relieving asthma, and promoting diuresis, and can be used for treating hyperpyrexia, unconsciousness, convulsive epilepsy, convulsion, arthralgia, cough and asthma due to lung heat, oliguria, edema, and hypertension.
Unprocessed radix aconiti lateralis: the traditional Chinese medicine is pungent and sweet in taste and strong in property and heat in nature, has the effects of restoring yang and relieving collapse, tonifying fire and supporting yang, and dispelling cold and relieving pain, and is mainly used for treating yang exhaustion and collapse, cold limbs and slight pulse, insufficient heart yang, chest stuffiness and pains, deficiency cold vomiting and diarrhea, abdominal cold pain, kidney yang deficiency and weakness, impotence and cold womb, yin cold edema, yang deficiency and external cold and cold-dampness arthralgia.
White impatiens stalk: is pungent and bitter in flavor and warm in nature, has the effects of dispelling wind, promoting blood circulation, relieving swelling and pain, and is mainly used for treating joint rheumatalgia, traumatic injury, scrofula, carbuncle and furuncle.
Trogopterus dung: bitter and sweet, warm in nature, has the effects of promoting blood circulation and relieving pain, and is mainly used for treating various pains of heart and abdomen blood and qi, amenorrhea of women, and postpartum pain caused by blood stasis; it can be used for treating snake bite, scorpion bite, and centipede bite. Stir-baked for stopping bleeding. It is indicated for metrorrhagia, menorrhagia and metrostaxis.
Musk: has pungent taste and warm nature, has effects of inducing resuscitation, refreshing mind, promoting blood circulation, dredging channels, relieving swelling and pain, and can be used for treating block syndrome unconsciousness, skin and external diseases, pyogenic infections, scrofula, subcutaneous nodule, sore throat, blood stasis, amenorrhea, abdominal mass, heart and abdominal pain, headache, traumatic injury, arthralgia due to wind-cold-dampness, dystocia, stillbirth, and retained afterbirth.
Deer-horn glue: has slight smell and slightly sweet taste, has the effects of warming and nourishing liver and kidney, replenishing vital essence and nourishing blood, and is mainly used for treating blood deficiency dizziness, soreness and coldness of waist and knees, consumptive disease and emaciation.
Ginger charcoal: is bitter in taste; pungent taste; astringency; warm in nature, has effects of warming channels, stopping bleeding, warming spleen and relieving diarrhea, and is mainly used for treating deficiency-cold hematemesis; hematochezia; (ii) metrorrhagia and metrostaxis; diarrhea due to yang deficiency.
Prepared rhizome of rehmannia: has sweet taste and mild nature, has the effects of nourishing yin and tonifying blood, and is mainly used for treating yin deficiency and blood deficiency, waist and knee weakness, overstrain cough and steaming bone, spermatorrhea, metrorrhagia, menoxenia, diabetes, scanty urine, deafness and blurred vision.
In the traditional Chinese medicine composition provided by the application, the traditional Chinese medicine composition takes burdock, white impatiens balsamina stems and rheum officinale with the functions of detoxifying and resolving masses as monarch drugs; herba schizonepetae, dried orange peel, cablin potchouli herb, teasel root, deerhorn glue, ginger carbon and prepared rhizome of rehmannia which have the functions of warming yang, reducing phlegm and dredging collaterals are taken as ministerial drugs; the Chinese angelica, the szechuan lovage rhizome, the cassia bark, the cassia twig, the red paeony root, the dahurian angelica root, the common bletilla pseudobulb, the cynanchum atratum bunge, the raw prepared common monkshood daughter root, the trogopterus dung and the musk have the effects of activating blood circulation, promoting qi circulation and removing blood stasis, and the prepared common monkshood mother root, the prepared kusnezoff monkshood mother root, the stiff silkworm, the frankincense. In addition, the schizonepeta, the dried orange peel, the patchouli, the teasel root, the deerhorn glue, the ginger carbon and the prepared rhizome of rehmannia also have the effects of warming yang, reducing phlegm and freeing channels, so that the combined traditional Chinese medicine composition has the effects of warming channels and tonifying yang, promoting qi and activating blood, expelling wind and removing cold, reducing phlegm and freeing channels, and can effectively treat non-lactation mastitis caused by heat-toxin accumulation. In addition, the traditional Chinese medicine composition provided by the application has the advantages of definite and safe curative effect, no toxic or side effect and capability of effectively reducing the anaphylactic reaction of a patient.
In the traditional Chinese medicine composition provided by the application, the preparation raw materials of the traditional Chinese medicine composition comprise, by mass, 1000-1500g of burdock, 100-120g of ligusticum wallichii, 40-60g of rheum officinale, 40-60g of angelica sinensis, 40-60g of radix aconiti preparata, 40-60g of prepared kusnezoff monkshood root, 40-60g of stiff silkworm, 40-60g of cinnamon, 40-60g of cassia twig, 40-60g of red paeony root, 40-60g of angelica dahurica, 40-60g of cynanchum atratum bunge, 40-60g of rhizoma bletillae, 40-60g of frankincense, 40-60g of myrrh, 20-30g of schizonepeta, 20-30g of dried orange peel, 20-30g of pogostemon cablin, 20-30g of teasel root, 20-30g of costus root, 40-60g of earthworm, 40-60g of unprocessed monkshood, 100-stem of radix, 20-30g of deerhorn glue, 20-30g of ginger carbon and 40-60g of prepared rhizome of rehmannia. More preferably, the raw materials for preparing the traditional Chinese medicine composition comprise, by mass, 1500g of burdock, 120g of ligusticum wallichii, 60g of rheum officinale, 60g of angelica sinensis, 60g of radix aconiti preparata, 60g of radix aconiti kusnezoffii preparata, 60g of stiff silkworm, 60g of cinnamon, 60g of cassia twig, 60g of radix paeoniae rubra, 60g of radix angelicae, 60g of cynanchum atratum bunge, 60g of rhizoma bletillae, 60g of frankincense, 60g of myrrh, 30g of schizonepeta, 30g of dried orange peel, 30g of pogostemon cablin, 30g of teasel root, 30g of costus root, 60g of earthworm, 60g of raw aconite, 120g of white impatiens balsamina stem, 30.
Furthermore, in order to bring convenience to patients to carry traditional Chinese medicines for treating non-lactation mastitis, the application also provides a traditional Chinese medicine external patch for treating non-lactation mastitis, and the traditional Chinese medicine external patch comprises an oil composition, an antiseptic, camphor, borneol, azone, distilled water and an extract prepared from the traditional Chinese medicine composition.
Wherein the oil composition is a substance for binding the extract prepared from the Chinese medicinal composition to increase the viscosity of the Chinese medicinal patch. In this application, the oil composition is prepared from sodium polyacrylate, shape-retaining agent, aluminum glycollate, ethylenediamine tetraacetic acid, titanium dioxide, tartaric acid, and glycerol.
Specifically, the sodium polyacrylate is a novel functional polymer material, the solid product is white or light yellow block or powder, and the liquid product is colorless or light yellow viscous liquid and is mainly used as a thickening agent, a water quality stabilizer, a dispersing agent and the like. The shape-maintaining agent is used for maintaining the dosage form of the traditional Chinese medicine external patch, and the shape-maintaining agent is made of materials commonly adopted in the traditional Chinese medicine industry or the food industry at present, such as pre-gelatinized starch, pre-gelatinized tapioca starch and the like. The chemical name of the dihydroxyaluminum glycinate is dihydroxyaluminum aminoacetate, and the dihydroxyaluminum glycinate has the effects of neutralizing gastric acid and astringing and stopping bleeding. Ethylenediaminetetraacetic acid is a white powder and can be used as a detergent, a blood anticoagulant, a pH regulator, and the like. Titanium dioxide is a white pigment, has the characteristics of no toxicity and no light transmittance, and is used for blending the color of the extract in the application. Tartaric acid is a carboxylic acid. In the application, the coordination among the ethylenediaminetetraacetic acid, the dihydroxyaluminium aminoacetate and the tartaric acid is used for adjusting the pH value of the traditional Chinese medicine external patch, so that the pH value of the traditional Chinese medicine external patch adapts to the skin of a human body, and the anaphylactic reaction of a patient is reduced. Glycerol is a lubricating substance, and is mainly used for improving the lubricity of the traditional Chinese medicine external patch and improving the comfort level of patients.
More preferably, the raw materials of the oil composition comprise 1080g of sodium polyacrylate, 130g of shape-maintaining agent, 20g of dihydroxyaluminium aminoacetate, 15g of ethylenediamine tetraacetic acid, 20g of titanium dioxide, 25g of tartaric acid and 5kg of glycerol according to the mass.
The antiseptic has effects of preventing microorganism infection and reproduction in the Chinese medicinal patch, and can prolong shelf life of the Chinese medicinal patch. The preservative adopted in the application is a material commonly adopted in the traditional Chinese medicine industry or the food industry at present, such as benzoic acid and salts thereof, sorbic acid and salts thereof, dehydroacetic acid, sodium salts and the like. The camphor and the borneol have the functions of refreshing and restoring consciousness and removing red swelling. Azone is a penetrating agent, is used as a penetration enhancer for external medicine application and massage, and can promote the absorption of effective components in the extract by human body. Distilled water is used for diluting the extract.
In the traditional Chinese medicine external application patch for treating non-lactation mastitis provided by the application, the preparation raw materials of the traditional Chinese medicine external application patch comprise, by mass, 1.5-3kg of extract, 5.8-6.7kg of oil composition, 80-120g of preservative, 20-40g of camphor, 20-40g of borneol, 80-120g of azone and 9-11kg of distilled water. More preferably, the raw materials for preparing the traditional Chinese medicine external patch comprise 2kg of extract, 6.290kg of oil composition, 100g of preservative, 30g of camphor, 30g of borneol, 100g of azone and 10kg of distilled water by mass.
Based on the traditional Chinese medicine external patch for treating non-lactation mastitis provided by the application, the application also provides a preparation method of the traditional Chinese medicine external patch for treating non-lactation mastitis, and the method comprises the following steps:
s01: decocting the raw materials for preparing the Chinese medicinal composition with water, filtering, and concentrating to obtain extract with relative density of 1.15-1.18.
Mixing the rhubarb, the prepared kusnezoff monkshood root and the prepared common monkshood mother root, adding water with the mass of 12 times of the rhubarb, the prepared common monkshood mother root and decocting for 2.5 hours for the first time; adding 10 times of water into the filtered filter residue, and decocting for 2h for the second time; adding 10 times of water into the filtered filter residue, and decocting for 2h for the third time; mixing the filtrates;
mixing cortex Cinnamomi, herba Schizonepetae, pericarpium Citri Tangerinae, herba Agastaches and radix aucklandiae, decocting with water for 2 times, adding 8 times of water each time, decocting for 1 hr each time, and mixing the filtrates;
mixing fructus Arctii, rhizoma Ligustici Chuanxiong, radix Angelicae sinensis, Bombyx Batryticatus, ramulus Cinnamomi, radix Paeoniae Rubra, radix Angelicae Dahuricae, radix Cynanchi Atrati, rhizoma Bletillae, Olibanum, Myrrha, radix Dipsaci, Lumbricus, radix Aconiti lateralis Preparata, caulis Impatientis, Oletum Trogopterori, Moschus, colla Cornus Cervi, charred rhizoma Zingiberis recens and radix rehmanniae Preparata, decocting with water for 2 times, adding 8 times of water for the first time, and decocting for 1 hr; adding 6 times of water by mass for the second time, and decocting for 1.5 h; mixing the two decoctions;
mixing all above filtrates, filtering at 60 deg.C, and concentrating to obtain extract of 1.15-1.18.
S02: mixing the oil composition with antiseptic, Camphora, Borneolum Syntheticum, and azone, and stirring to obtain colloid.
Mixing the above materials with antiseptic, Camphora, Borneolum Syntheticum, and azone, stirring, and making into colloid. In the process of preparing the colloid, samples are respectively taken at different depths of the stirrer, the content of a certain medicinal material in the sample is tested, and whether the substances are uniformly stirred or not is further judged.
S03: and mixing the extract, the colloid and distilled water, and stirring in vacuum to form a binder.
Mixing the extract with distilled water, hydrating, adding the colloid into the mixture of the extract and the distilled water, and stirring under negative atmospheric pressure to obtain the binder. The vacuum stirring is used for squeezing air in the medicine to prevent air bubbles from forming after the medicine is prepared, occupies the space of the traditional Chinese medicine external patch and reduces the effective components.
S04: the adhesive is evenly coated with glue, sliced and solidified to form the traditional Chinese medicine external application patch.
And (5) uniformly gluing the adhesive, and controlling the weight of the sheet. The gummed adhesive is formed into a sheet-shaped traditional Chinese medicine external application patch in a slicing mode so as to be convenient for a patient to apply. Slicing is carried out after the glue is coated, so that the slicing uniformity can be ensured, and meanwhile, the good gluing fitting degree is ensured. The sheet-shaped traditional Chinese medicine external application patch is solidified for 48 hours at room temperature to form the portable traditional Chinese medicine external application patch.
The technical scheme provided by the embodiment of the invention can have the following beneficial effects:
the invention relates to a traditional Chinese medicine composition for treating non-lactation mastitis, a traditional Chinese medicine external patch and a preparation method. In the traditional Chinese medicine composition provided by the application, the traditional Chinese medicine composition takes burdock, white impatiens balsamina stems and rheum officinale with the functions of detoxifying and resolving masses as monarch drugs; herba schizonepetae, dried orange peel, cablin potchouli herb, teasel root, deerhorn glue, ginger carbon and prepared rhizome of rehmannia which have the functions of warming yang, reducing phlegm and dredging collaterals are taken as ministerial drugs; the Chinese angelica, the szechuan lovage rhizome, the cassia bark, the cassia twig, the red paeony root, the dahurian angelica root, the common bletilla pseudobulb, the cynanchum atratum bunge, the raw prepared common monkshood daughter root, the trogopterus dung and the musk have the effects of activating blood circulation, promoting qi circulation and removing blood stasis, and the prepared common monkshood mother root, the prepared kusnezoff monkshood mother root, the stiff silkworm, the frankincense. In addition, the schizonepeta, the dried orange peel, the patchouli, the teasel root, the deerhorn glue, the ginger carbon and the prepared rhizome of rehmannia also have the effects of warming yang, reducing phlegm and freeing channels, so that the combined traditional Chinese medicine composition has the effects of warming channels and tonifying yang, promoting qi and activating blood, expelling wind and removing cold, reducing phlegm and freeing channels, and can effectively treat non-lactation mastitis caused by heat-toxin accumulation. In addition, the traditional Chinese medicine composition provided by the application has the advantages of definite and safe curative effect, no toxic or side effect and capability of effectively reducing the anaphylactic reaction of a patient. The traditional Chinese medicine external application patch has the effect of treating non-lactation mastitis and is convenient to carry.
It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the invention, as claimed.
Drawings
In order to more clearly explain the technical solution of the present application, the drawings needed to be used in the embodiments will be briefly described below, and it is obvious to those skilled in the art that other drawings can be obtained according to the drawings without any creative effort.
Fig. 1 is a schematic flow chart of a preparation method of a traditional Chinese medicine external patch for treating non-lactation mastitis provided by the embodiment of the invention.
Detailed Description
Referring to fig. 1, fig. 1 is a schematic flow chart of a method for preparing a traditional Chinese medicine external patch for treating non-lactation mastitis provided by an embodiment of the application. The following description of the embodiments is based on fig. 1.
Example 1
The embodiment of the application provides a traditional Chinese medicine composition for treating non-lactation mastitis, and the traditional Chinese medicine composition comprises 1500g of burdock, 120g of ligusticum wallichii, 60g of rheum officinale, 60g of angelica sinensis, 60g of radix aconiti preparata, 60g of prepared kusnezoff monkshood root, 60g of stiff silkworm, 60g of cinnamon, 60g of cassia twig, 60g of red paeony root, 60g of radix angelicae, 60g of cynanchum atratum, 60g of rhizoma bletillae, 60g of frankincense, 60g of myrrh, 30g of schizonepeta, 30g of dried orange peel, 30g of pogostemon cablin, 30g of teasel root, 30g of costus root, 60g of earthworm, 60g of raw monkshood, 120g of white impatiens balsamina stem, 30g of trogopterus dung, 30.
Example 2
The embodiment of the application provides a traditional Chinese medicine composition for treating non-lactation mastitis, and the traditional Chinese medicine composition comprises 1000g of burdock, 100g of ligusticum wallichii, 40g of rheum officinale, 40g of angelica sinensis, 40g of radix aconiti preparata, 40g of prepared kusnezoff monkshood root, 40g of stiff silkworm, 40g of cinnamon, 40g of cassia twig, 40g of red paeony root, 40g of radix angelicae, 40g of cynanchum atratum, 40g of rhizoma bletillae, 40g of frankincense, 40g of myrrh, 20g of schizonepeta, 20g of dried orange peel, 20g of pogostemon cablin, 20g of teasel root, 20g of costus root, 40g of earthworm, 40g of raw monkshood, 100g of caulis sinomenii brevicari, 20g of trogopterus dung, 20.
Example 3
The embodiment of the application provides a traditional Chinese medicine composition for treating non-lactation mastitis, and the traditional Chinese medicine composition comprises 1500g of burdock, 120g of ligusticum wallichii, 60g of rheum officinale, 60g of angelica sinensis, 60g of radix aconiti preparata, 60g of prepared kusnezoff monkshood root, 60g of stiff silkworm, 60g of cinnamon, 60g of cassia twig, 60g of red paeony root, 60g of radix angelicae, 60g of cynanchum atratum, 60g of rhizoma bletillae, 60g of frankincense, 60g of myrrh, 30g of schizonepeta, 30g of dried orange peel, 30g of pogostemon cablin, 30g of teasel root, 30g of costus root, 60g of earthworm, 60g of raw monkshood, 120g of white impatiens balsamina stem, 30g of trogopterus dung, 30.
Example 4
The embodiment of the application provides a traditional Chinese medicine composition for treating non-lactation mastitis, and the traditional Chinese medicine composition comprises 1200g of burdock, 110g of ligusticum wallichii, 50g of rheum officinale, 50g of angelica sinensis, 50g of radix aconiti preparata, 50g of prepared kusnezoff monkshood root, 50g of stiff silkworm, 50g of cinnamon, 50g of cassia twig, 50g of red paeony root, 50g of radix angelicae, 50g of cynanchum atratum, 50g of rhizoma bletillae, 50g of frankincense, 50g of myrrh, 25g of schizonepeta, 25g of dried orange peel, 25g of pogostemon cablin, 25g of teasel root, 25g of costus root, 50g of earthworm, 50g of raw monkshood, 110g of caulis sinomenii brevicari, 25g of trogopterus dung, 25.
Example 5
The embodiment of the application provides a traditional Chinese medicine external patch for treating non-lactation mastitis, and the traditional Chinese medicine external patch is prepared from 2kg of extract, 6.290kg of oil composition, 100g of preservative, 30g of camphor, 30g of borneol, 100g of azone and 10kg of distilled water according to mass. Wherein, the preparation raw materials of the oil composition comprise 1080g of sodium polyacrylate, 130g of shape-maintaining agent, 20g of dihydroxyaluminium aminoacetate, 15g of ethylenediamine tetraacetic acid, 20g of titanium dioxide, 25g of tartaric acid and 5kg of glycerol according to the mass.
Based on the traditional Chinese medicine external application patch, the embodiment of the application also provides a preparation method of the traditional Chinese medicine external application patch, and the method comprises the following steps:
s501: mixing the rhubarb, the prepared kusnezoff monkshood root and the prepared common monkshood mother root, adding water with the mass of 12 times of the rhubarb, the prepared common monkshood mother root and decocting for 2.5 hours for the first time; adding 10 times of water into the filtered filter residue, and decocting for 2h for the second time; adding 10 times of water into the filtered filter residue, and decocting for 2h for the third time; mixing the filtrates; mixing cortex Cinnamomi, herba Schizonepetae, pericarpium Citri Tangerinae, herba Agastaches and radix aucklandiae, decocting with water for 2 times, adding 8 times of water each time, decocting for 1 hr each time, and mixing the filtrates; mixing fructus Arctii, rhizoma Ligustici Chuanxiong, radix Angelicae sinensis, Bombyx Batryticatus, ramulus Cinnamomi, radix Paeoniae Rubra, radix Angelicae Dahuricae, radix Cynanchi Atrati, rhizoma Bletillae, Olibanum, Myrrha, radix Dipsaci, Lumbricus, radix Aconiti lateralis Preparata, caulis Impatientis, Oletum Trogopterori, Moschus, colla Cornus Cervi, charred rhizoma Zingiberis recens and radix rehmanniae Preparata, decocting with water for 2 times, adding 8 times of water for the first time, and decocting for 1 hr; adding 6 times of water by mass for the second time, and decocting for 1.5 h; mixing the two decoctions; mixing all above filtrates, filtering at 60 deg.C, and concentrating to obtain extract of 1.15-1.18.
S502: mixing the above materials with antiseptic, Camphora, Borneolum Syntheticum, and azone, stirring, and making into colloid.
S503: mixing the extract with distilled water, hydrating, adding the colloid into the mixture of the extract and the distilled water, and stirring under negative atmospheric pressure to obtain the binder.
S504: and (5) uniformly gluing the adhesive, and controlling the weight of the sheet. The gummed adhesive is formed into a sheet-shaped traditional Chinese medicine external application patch in a slicing mode so as to be convenient for a patient to apply. The sheet-shaped traditional Chinese medicine external application patch is solidified for 48 hours at room temperature to form the portable traditional Chinese medicine external application patch.
Example 6
The embodiment of the application provides a traditional Chinese medicine external application patch for treating non-lactation mastitis, and the traditional Chinese medicine external application patch is prepared from 1.5kg of extract, 5.8kg of oil composition, 80g of preservative, 20g of camphor, 20g of borneol, 80g of azone and 9kg of distilled water by mass. Wherein, the preparation raw materials of the oil composition comprise 900g of sodium polyacrylate, 100g of shape-maintaining agent, 20g of dihydroxyaluminium glycinate, 15g of ethylenediamine tetraacetic acid, 10g of titanium dioxide, 20g of tartaric acid and 4.735kg of glycerol according to the mass.
Based on the traditional Chinese medicine external application patch, the embodiment of the application also provides a preparation method of the traditional Chinese medicine external application patch, and the specific process of the preparation method refers to embodiment 5.
Example 7
The embodiment of the application provides a traditional Chinese medicine external application patch for treating non-lactation mastitis, and the traditional Chinese medicine external application patch is prepared from 3kg of extract, 6.7kg of oil composition, 120g of preservative, 40g of camphor, 4g of borneol, 120g of azone and 11kg of distilled water by mass. Wherein, the preparation raw materials of the oil composition comprise 1150g of sodium polyacrylate, 130g of shape-maintaining agent, 30g of dihydroxyaluminium aminoacetate, 25g of ethylenediamine tetraacetic acid, 20g of titanium dioxide, 30g of tartaric acid and 5.315kg of glycerol according to the mass.
Based on the traditional Chinese medicine external application patch, the embodiment of the application also provides a preparation method of the traditional Chinese medicine external application patch, and the specific process of the preparation method refers to embodiment 5.
Example 8
The embodiment of the application provides a traditional Chinese medicine external application patch for treating non-lactation mastitis, and the traditional Chinese medicine external application patch is prepared from 1.8kg of extract, 6kg of oil composition, 90g of preservative, 35g of camphor, 24g of borneol, 90g of azone and 9.5kg of distilled water by mass. Wherein, the preparation raw materials of the oil composition comprise 1000g of sodium polyacrylate, 110g of shape-keeping agent, 28g of dihydroxyaluminium aminoacetate, 18g of ethylenediamine tetraacetic acid, 18g of titanium dioxide, 22g of tartaric acid and 4.804kg of glycerol by mass.
Based on the traditional Chinese medicine external application patch, the embodiment of the application also provides a preparation method of the traditional Chinese medicine external application patch, and the specific process of the preparation method refers to embodiment 5.
Other embodiments of the invention will be apparent to those skilled in the art from consideration of the specification and practice of the disclosure herein. This application is intended to cover any variations, uses, or adaptations of the invention following, in general, the principles of the invention and including such departures from the present disclosure as come within known or customary practice within the art to which the invention pertains. It is intended that the specification and examples be considered as exemplary only, with a true scope and spirit of the invention being indicated by the following claims.
It is to be understood that relational terms such as "first" and "second," and the like, may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. The invention is not limited to the precise arrangements described above and shown in the drawings, and various modifications and changes may be made without departing from the scope thereof. The scope of the invention is limited only by the appended claims.

Claims (10)

1. A traditional Chinese medicine composition for treating non-lactation mastitis is characterized in that the traditional Chinese medicine composition is prepared from burdock, ligusticum wallichii, rheum officinale, angelica sinensis, radix aconiti preparata, prepared kusnezoff monkshood root, stiff silkworm, cinnamon, cassia twig, red paeony root, angelica dahurica, cynanchum atratum, rhizoma bletillae, frankincense, myrrh, schizonepeta, dried orange peel, patchouli, teasel root, costus root, earthworm, unprocessed monkshood root, clematis root stalk, trogopterus dung, musk, deerhorn glue, ginger carbon and prepared rhizome of rehmannia.
2. The traditional Chinese medicine composition as claimed in claim 1, wherein the raw materials for preparing the traditional Chinese medicine composition comprise, by mass, 1000-1500g of burdock, 100-120g of ligusticum wallichii, 40-60g of rheum officinale, 40-60g of angelica sinensis, 40-60g of radix aconiti preparata, 40-60g of prepared kusnezoff monkshood root, 40-60g of stiff silkworm, 40-60g of cinnamon, 40-60g of cassia twig, 40-60g of red peony root, 40-60g of angelica dahurica, 40-60g of cynanchum atratum, 40-60g of rhizoma bletillae, 40-60g of frankincense, 40-60g of myrrh, 20-30g of schizonepeta, 20-30g of dried orange peel, 20-30g of pogostemon cablin, 20-30g of teasel root, 20-30g of saussurea costus root, 40-60g of earthworm, 40-60g of, 20-30g of trogopterus dung, 20-30g of musk, 20-30g of deerhorn glue, 20-30g of ginger carbon and 40-60g of prepared rhizome of rehmannia.
3. The traditional Chinese medicine composition as claimed in claim 1, wherein the raw materials for preparing the traditional Chinese medicine composition comprise, by mass, 1500g of burdock, 120g of ligusticum wallichii, 60g of rheum officinale, 60g of angelica sinensis, 60g of radix aconiti preparata, 60g of radix aconiti kusnezoffii preparata, 60g of stiff silkworm, 60g of cinnamon, 60g of cassia twig, 60g of radix paeoniae rubra, 60g of radix angelicae, 60g of cynanchum atratum, 60g of rhizoma bletillae, 60g of frankincense, 60g of myrrh, 30g of herba schizonepetae, 30g of pericarpium citri reticulatae, 30g of pogostemon cablin, 30g of radix dipsaci, 30g of costus root, 60g of earthworm, 60g of radix aconiti lateralis preparata, 120g of caulis impatientis balsamin.
4. A traditional Chinese medicine external patch for treating non-lactation mastitis is characterized in that the preparation raw materials of the traditional Chinese medicine external patch comprise an oil composition, a preservative, camphor, borneol, azone, distilled water and an extract prepared from the traditional Chinese medicine composition of any one of claims 1 to 3.
5. The traditional Chinese medicine patch for external application of claim 4, wherein the raw materials for preparing the traditional Chinese medicine patch for external application comprise, by mass, 1.5 to 3kg of extract, 5.8 to 6.7kg of oil composition, 80 to 120g of preservative, 20 to 40g of camphor, 20 to 40g of borneol, 80 to 120g of azone and 9 to 11kg of distilled water.
6. The external traditional Chinese medicine patch according to claim 4, wherein the raw materials for preparing the external traditional Chinese medicine patch comprise, by mass, 2kg of extract, 6.290kg of oil composition, 100g of preservative, 30g of camphor, 30g of borneol, 100g of azone and 10kg of distilled water.
7. The topical Chinese medicinal patch of claim 4, wherein the oil composition is prepared from sodium polyacrylate, shape keeping agent, aluminum glycollate, ethylenediamine tetraacetic acid, titanium pigment, tartaric acid, and glycerol.
8. The external traditional Chinese medicine patch according to claim 4, wherein the oil composition is prepared from raw materials including, by mass, 1080g of sodium polyacrylate, 130g of shape-maintaining agent, 20g of dihydroxyaluminium aminoacetate, 15g of ethylenediaminetetraacetic acid, 20g of titanium dioxide, 25g of tartaric acid and 5kg of glycerin.
9. A preparation method of a traditional Chinese medicine external patch for treating non-lactation mastitis is characterized by comprising the following steps:
decocting the raw materials for preparing the Chinese medicinal composition of any one of claims 1-3 with water, filtering, and concentrating to obtain extract with relative density of 1.15-1.18;
mixing the raw materials for preparing the oil composition with antiseptic, Camphora, Borneolum Syntheticum, and azone, and stirring to obtain colloid;
mixing the extract, the colloid and distilled water, and stirring in vacuum to form a binder;
the adhesive is evenly coated with glue, sliced and solidified to form the traditional Chinese medicine external application patch.
10. The method for preparing a Chinese medicinal patch for external application according to claim 9,
mixing the rhubarb, the prepared kusnezoff monkshood root and the prepared common monkshood mother root, adding water with the mass of 12 times of the rhubarb, the prepared common monkshood mother root and decocting for 2.5 hours for the first time; adding 10 times of water into the filtered filter residue, and decocting for 2h for the second time; adding 10 times of water into the filtered filter residue, and decocting for 2h for the third time; mixing the filtrates;
mixing cortex Cinnamomi, herba Schizonepetae, pericarpium Citri Tangerinae, herba Agastaches and radix aucklandiae, decocting with water for 2 times, adding 8 times of water each time, decocting for 1 hr each time, and mixing the filtrates;
mixing fructus Arctii, rhizoma Ligustici Chuanxiong, radix Angelicae sinensis, Bombyx Batryticatus, ramulus Cinnamomi, radix Paeoniae Rubra, radix Angelicae Dahuricae, radix Cynanchi Atrati, rhizoma Bletillae, Olibanum, Myrrha, radix Dipsaci, Lumbricus, radix Aconiti lateralis Preparata, caulis Impatientis, Oletum Trogopterori, Moschus, colla Cornus Cervi, charred rhizoma Zingiberis recens and radix rehmanniae Preparata, decocting with water for 2 times, adding 8 times of water for the first time, and decocting for 1 hr; adding 6 times of water by mass for the second time, and decocting for 1.5 h; mixing the two decoctions;
mixing all above filtrates, filtering at 60 deg.C, and concentrating to obtain extract of 1.15-1.18.
CN202010928140.0A 2020-09-07 2020-09-07 Traditional Chinese medicine composition for treating non-lactation mastitis, traditional Chinese medicine external patch and preparation method Pending CN111905091A (en)

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Publication number Priority date Publication date Assignee Title
CN107095898A (en) * 2017-02-16 2017-08-29 南京中医药大学 A kind of herbal mixture for treating Nonpuerperal mastitis
CN109432203A (en) * 2018-12-29 2019-03-08 中国中医科学院西苑医院 For treating the pharmaceutical composition and Chinese medicine material composition of Nonpuerperal mastitis
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CN107095898A (en) * 2017-02-16 2017-08-29 南京中医药大学 A kind of herbal mixture for treating Nonpuerperal mastitis
CN109432203A (en) * 2018-12-29 2019-03-08 中国中医科学院西苑医院 For treating the pharmaceutical composition and Chinese medicine material composition of Nonpuerperal mastitis
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