CN111905075A - Traditional Chinese medicine preparation for warming middle-jiao and harmonizing stomach and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for warming middle-jiao and harmonizing stomach and preparation method thereof Download PDFInfo
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- CN111905075A CN111905075A CN202010795985.7A CN202010795985A CN111905075A CN 111905075 A CN111905075 A CN 111905075A CN 202010795985 A CN202010795985 A CN 202010795985A CN 111905075 A CN111905075 A CN 111905075A
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- parts
- stomach
- fructus
- bark
- jiao
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine preparation for warming middle-jiao and harmonizing stomach, and particularly relates to the technical field of traditional Chinese medicines, which comprises the following raw materials: costustoot, fructus amomi, bighead atractylodes rhizome, dried orange peel, poria cocos, pinellia ternate, cyperus rotundus, immature bitter orange, round cardamom, ginger officinal magnolia bark, cablin potchouli herb, liquorice, Chinese date, galangal, evodia rutaecarpa, cinnamomum burmanni bark and long pepper. The invention can ensure the normal efficacy of the stomach pill of aucklandia and amomum fruit; can effectively strengthen warm zhong stomach harmonization treatment effect, can mutually support between the medicinal material simultaneously, the performance effect of active substance in the medicine can be effectively strengthened, can effectively reduce the particle size of medicinal material, make to extract the volatile oil to the medicinal material, decocte and percolation treatment effect are better, can extract the active ingredient of volatile oil in the medicinal material, the medicinal material leaves reserve component simultaneously, active substance draws more comprehensively in the medicinal material, make active ingredient performance effect in the medicine better, can effectively strengthen the mixed processing effect of each material and material, the treatment effect is better.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine preparation for warming middle-jiao and harmonizing stomach and a preparation method thereof.
Background
The Chinese traditional medicine theory is used for guiding collection, processing and preparation, explaining the action mechanism and guiding the medicines for clinical application, which are collectively called as traditional Chinese medicines. In short, a Chinese medicine is a substance which is used for preventing, treating and diagnosing diseases and has the effects of rehabilitation and health care under the guidance of the theory of traditional Chinese medicine. The Chinese medicine is mainly prepared from natural medicines and processed products thereof, including plant medicines, animal medicines, mineral medicines and partial chemical and biological products. The xiangsha yangwei pills are Chinese patent medicines, are interior-warming agents, have the effects of warming middle-jiao and harmonizing stomach, and are mainly used for treating stomachache and fullness caused by stomach-yang deficiency and damp obstruction and qi stagnation, and have the symptoms of dull and hidden stomachache, discomfort in epigastrium, acid regurgitation, discomfort in gastric upset, poor appetite and lassitude in limbs.
The traditional Chinese medicine preparation for warming the middle-jiao and harmonizing the stomach has poor effect of effective substances in the medicine and poor treatment effect.
Disclosure of Invention
In order to overcome the above defects of the prior art, the embodiment of the invention provides a traditional Chinese medicine preparation for warming middle-jiao and harmonizing stomach and a preparation method thereof, and the invention aims to solve the following problems: how to strengthen the effect of effective substances in the medicine and improve the treatment effect.
In order to achieve the purpose, the invention provides the following technical scheme: a traditional Chinese medicine preparation for warming middle-jiao and harmonizing stomach comprises the following raw materials in parts by weight: 50-90 parts of costustoot, 50-90 parts of fructus amomi, 70-130 parts of bighead atractylodes rhizome, 70-130 parts of dried orange peel, 70-130 parts of poria cocos, 70-130 parts of pinellia ternate, 50-90 parts of cyperus rotundus, 50-90 parts of immature bitter orange, 50-90 parts of round cardamom, 50-90 parts of ginger magnolia bark, 50-90 parts of patchouli, 10-50 parts of liquorice, 30-70 parts of Chinese date, 10-50 parts of galangal, 10-50 parts of fructus evodiae, 10-50 parts of cinnamomum burmannii bark and 10-50 parts of long pepper;
in a preferred embodiment, the feed comprises the following raw materials in parts by weight: 50 parts of costustoot, 50 parts of fructus amomi, 70 parts of bighead atractylodes rhizome, 70 parts of dried orange peel, 70 parts of poria cocos, 70 parts of pinellia ternate, 50 parts of cyperus rotundus, 50 parts of immature bitter orange, 50 parts of cardamom, 50 parts of officinal magnolia bark, 50 parts of cablin potchouli herb, 10 parts of liquorice, 30 parts of Chinese date, 10 parts of galangal, 10 parts of evodia rutaecarpa, 10 parts of cinnamomum burmannii bark and 10 parts of long pepper.
In a preferred embodiment, the feed comprises the following raw materials in parts by weight: 90 parts of costustoot, 90 parts of fructus amomi, 130 parts of bighead atractylodes rhizome, 130 parts of dried orange peel, 130 parts of poria cocos, 130 parts of pinellia ternate, 90 parts of cyperus rotundus, 90 parts of immature bitter orange, 90 parts of cardamom, 90 parts of cortex magnoliae officinalis, 90 parts of pogostemon cablin, 50 parts of liquorice, 70 parts of Chinese date, 50 parts of galangal, 50 parts of fructus evodiae, 50 parts of cinnamomum burmannii bark and 50 parts of long pepper.
In a preferred embodiment, the feed comprises the following raw materials in parts by weight: 70 parts of costustoot, 70 parts of fructus amomi, 100 parts of bighead atractylodes rhizome, 100 parts of dried orange peel, 100 parts of poria cocos, 100 parts of pinellia ternate, 70 parts of cyperus rotundus, 70 parts of immature bitter orange, 70 parts of cardamom, 70 parts of officinal magnolia bark with ginger, 70 parts of cablin potchouli herb, 30 parts of liquorice, 50 parts of Chinese date, 30 parts of galangal, 30 parts of evodia rutaecarpa, 30 parts of cinnamomum burmannii bark and 30 parts of long.
In a preferred embodiment, the costustoot, the fructus amomi, the bighead atractylodes rhizome, the dried orange peel, the poria cocos, the pinellia ternate, the cyperus rotundus, the immature bitter orange, the round cardamom, the cortex magnoliae officinalis, the pogostemon cablin, the liquorice, the Chinese date, the galangal, the fructus evodiae, the cinnamomum burmannii bark and the long pepper are selected from products without plant diseases and insect pests.
In a preferred embodiment, the pinellia tuber is processed pinellia tuber, the cyperus rotundus is vinegar-processed cyperus rotundus, the immature bitter orange is bran-fried immature bitter orange, and the round cardamom is shelled.
The invention also provides a preparation method of the traditional Chinese medicine preparation for warming middle-jiao and harmonizing stomach, which comprises the following specific preparation steps:
the method comprises the following steps: weighing the costustoot, the villous amomum fruit, the largehead atractylodes rhizome, the tangerine peel, the Indian buead, the pinellia tuber, the cyperus rotundus, the immature bitter orange, the round cardamom, the officinal magnolia bark with ginger, the cablin potchouli herb, the liquoric root, the Chinese date, the galangal, the evodia rutaecarpa, the cinnamomum burmannii bark and;
step two: pulverizing radix aucklandiae, fructus Amomi, Atractylodis rhizoma, pericarpium Citri Tangerinae, Poria, rhizoma Pinelliae, rhizoma Cyperi, fructus Aurantii Immaturus, fructus Amomi rotundus, cortex Magnolia officinalis, herba Agastaches, Glycyrrhrizae radix, fructus Jujubae, rhizoma Alpiniae Officinarum, fructus evodiae, cortex Cinnamomi Burmannii and fructus Piperis Longi respectively, and sieving with 10-20 mesh sieve;
step three: performing steam distillation on pericarpium Citri Tangerinae, rhizoma Cyperi, fructus Aurantii Immaturus, cortex Magnolia officinalis, herba Agastaches and three-fourths of radix aucklandiae, rhizoma Alpiniae Officinarum, fructus evodiae, cortex Cinnamomi Burmannii and fructus Piperis Longi by weight to obtain volatile oil A and residue B;
step four: mixing the residue B with Atractylodis rhizoma, Poria, Glycyrrhrizae radix, fructus Jujubae, rhizoma Pinelliae (one fifth of the weight parts), the rest fructus evodiae and fructus Piperis Longi, decocting with water for three times (3 hr for the first time, 2 hr for the second time, and 1 hr for the third time), mixing decoctions, centrifuging, filtering to obtain residue C and filtrate, and concentrating the filtrate into soft extract D with relative density of 1.36-1.138(20 deg.C);
step four: soaking residue C, herba Agastaches, the rest radix aucklandiae, rhizoma Alpiniae Officinarum and cortex Cinnamomi Burmannii in 70% ethanol for 24 hr, percolating, collecting percolate, recovering ethanol, and concentrating under reduced pressure to obtain soft extract E with relative density of 1.36-1.38(20 deg.C);
step five: grinding fructus Amomi, fructus Amomi rotundus and the rest rhizoma Pinelliae, sieving with 300-400 mesh sieve, and mixing to obtain mixture F;
step six: mixing the substance volatile oil A, stirring and mixing the thick paste D and half of the mixture F by weight, gradually adding one third of the substance volatile oil A in the stirring process to obtain a mixture G, stirring and mixing the thick paste E and the rest mixture F, and gradually adding one third of the substance volatile oil A in the stirring process to obtain a mixture H;
step seven: and (3) uniformly stirring and mixing the mixture G and the mixture H, adding the residual volatile oil A in the stirring process, finally making pills, drying and polishing to obtain the stomach-nourishing xiangsha pills.
In a preferred embodiment, before step two, the costustoot, the villous amomum fruit, the largehead atractylodes rhizome, the tangerine peel, the Indian buead, the pinellia tuber, the nutgrass flatsedge rhizome, the immature bitter orange, the round cardamom fruit, the officinal magnolia bark, the cablin potchouli herb, the liquoric root, the Chinese date, the galangal, the medicinal evodia fruit, the cinnamomum burmannii bark and the long pepper are cleaned, decontamina.
In a preferred embodiment, each substance volatile oil A is stored in a sealed manner, and the sealing treatment is carried out during the mixing and adding process of each substance volatile oil A.
In a preferred embodiment, the percolation treatment is carried out in step four using a counter-current percolation method.
The invention has the technical effects and advantages that:
1. the traditional Chinese medicine preparation for warming the middle-jiao and harmonizing the stomach, which is prepared by adopting the raw material formula of the invention, can ensure the normal efficacy of the stomach-nourishing pill of aucklandia root and amomum fruit; the galangal, the evodia rutaecarpa, the cinnamomum burmannii bark and the long pepper can effectively enhance the treatment effect of warming the middle-jiao and harmonizing the stomach, meanwhile, the medicinal materials can be mutually matched, the drug effect is further enhanced, the exertion effect of effective substances in the medicine can be effectively enhanced, and the treatment effect is better;
2. in the process of preparing the traditional Chinese medicine preparation for warming middle-jiao and harmonizing stomach, the particle size of the medicinal materials can be effectively reduced, so that the effects of extracting volatile oil from the medicinal materials, decocting and percolating the medicinal materials are better, the extraction of effective components in the medicinal materials is quicker, the effective components of the volatile oil in the medicinal materials can be extracted, the medicine effect is ensured, meanwhile, standby components are reserved in the medicinal materials and are added into the subsequent decocting and percolating treatment, the extraction of effective substances in the medicinal materials is more comprehensive, the effect of exerting the effective components in the medicinal materials is better, the mixing treatment effect of various substances and materials can be effectively enhanced, the effect of exerting the effective substances in the medicinal materials is better, and the treatment effect is better.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1:
the invention provides a traditional Chinese medicine preparation for warming middle-jiao and harmonizing stomach, which comprises the following raw materials in parts by weight: 50 parts of costustoot, 50 parts of fructus amomi, 70 parts of bighead atractylodes rhizome, 70 parts of dried orange peel, 70 parts of poria cocos, 70 parts of pinellia ternate, 50 parts of cyperus rotundus, 50 parts of immature bitter orange, 50 parts of cardamom, 50 parts of officinal magnolia bark, 50 parts of cablin potchouli herb, 10 parts of liquorice, 30 parts of Chinese date, 10 parts of galangal, 10 parts of evodia rutaecarpa, 10 parts of cinnamomum burmannii bark and 10 parts of long pepper;
the costustoot, the fructus amomi, the bighead atractylodes rhizome, the dried orange peel, the poria cocos, the pinellia ternate, the cyperus rotundus, the immature bitter orange, the round cardamom, the ginger magnolia officinalis, the cablin potchouli herb, the liquorice, the Chinese date, the galangal, the evodia rutaecarpa, the cinnamomum burmannii bark and the long pepper are all products without plant diseases and insect pests, so that the safety of.
The pinellia ternate is prepared pinellia ternate, the cyperus rotundus is vinegar-fried cyperus rotundus, the immature bitter orange is bran-fried immature bitter orange, and the round cardamom is shelled.
The invention also provides a preparation method of the traditional Chinese medicine preparation for warming middle-jiao and harmonizing stomach, which comprises the following specific preparation steps:
the method comprises the following steps: weighing the costustoot, the villous amomum fruit, the largehead atractylodes rhizome, the tangerine peel, the Indian buead, the pinellia tuber, the cyperus rotundus, the immature bitter orange, the round cardamom, the officinal magnolia bark with ginger, the cablin potchouli herb, the liquoric root, the Chinese date, the galangal, the evodia rutaecarpa, the cinnamomum burmannii bark and;
step two: pulverizing radix aucklandiae, fructus Amomi, Atractylodis rhizoma, pericarpium Citri Tangerinae, Poria, rhizoma Pinelliae, rhizoma Cyperi, fructus Aurantii Immaturus, fructus Amomi rotundus, cortex Magnolia officinalis, herba Agastaches, Glycyrrhrizae radix, fructus Jujubae, rhizoma Alpiniae Officinarum, fructus evodiae, cortex Cinnamomi Burmannii and fructus Piperis Longi respectively, and sieving with 10-20 mesh sieve;
step three: performing steam distillation on pericarpium Citri Tangerinae, rhizoma Cyperi, fructus Aurantii Immaturus, cortex Magnolia officinalis, herba Agastaches and three-fourths of radix aucklandiae, rhizoma Alpiniae Officinarum, fructus evodiae, cortex Cinnamomi Burmannii and fructus Piperis Longi by weight to obtain volatile oil A and residue B;
step four: mixing the residue B with Atractylodis rhizoma, Poria, Glycyrrhrizae radix, fructus Jujubae, rhizoma Pinelliae (one fifth of the weight parts), the rest fructus evodiae and fructus Piperis Longi, decocting with water for three times (3 hr for the first time, 2 hr for the second time, and 1 hr for the third time), mixing decoctions, centrifuging, filtering to obtain residue C and filtrate, and concentrating the filtrate into soft extract D with relative density of 1.36-1.138(20 deg.C);
step four: soaking residue C, herba Agastaches, the rest radix aucklandiae, rhizoma Alpiniae Officinarum and cortex Cinnamomi Burmannii in 70% ethanol for 24 hr, percolating, collecting percolate, recovering ethanol, and concentrating under reduced pressure to obtain soft extract E with relative density of 1.36-1.38(20 deg.C);
step five: grinding fructus Amomi, fructus Amomi rotundus and the rest rhizoma Pinelliae, sieving with 300-400 mesh sieve, and mixing to obtain mixture F;
step six: mixing the substance volatile oil A, stirring and mixing the thick paste D and half of the mixture F by weight, gradually adding one third of the substance volatile oil A in the stirring process to obtain a mixture G, stirring and mixing the thick paste E and the rest mixture F, and gradually adding one third of the substance volatile oil A in the stirring process to obtain a mixture H;
step seven: and (3) uniformly stirring and mixing the mixture G and the mixture H, adding the residual volatile oil A in the stirring process, finally making pills, drying and polishing to obtain the stomach-nourishing xiangsha pills.
Cleaning, impurity removing and drying costustoot, fructus amomi, bighead atractylodes rhizome, dried orange peel, poria cocos, pinellia ternate, cyperus rotundus, immature bitter orange, round cardamom, cortex magnoliae officinalis, cablin potchouli herb, liquorice, Chinese date, galangal, fructus evodiae, cinnamomum burmannii bark and long pepper before the second step.
Sealing and storing the volatile oil A, and sealing during the mixing and adding process of the volatile oil A.
And percolating by countercurrent percolation.
Example 2:
different from the embodiment 1, the material comprises the following raw materials in parts by weight: 90 parts of costustoot, 90 parts of fructus amomi, 130 parts of bighead atractylodes rhizome, 130 parts of dried orange peel, 130 parts of poria cocos, 130 parts of pinellia ternate, 90 parts of cyperus rotundus, 90 parts of immature bitter orange, 90 parts of cardamom, 90 parts of cortex magnoliae officinalis, 90 parts of pogostemon cablin, 50 parts of liquorice, 70 parts of Chinese date, 50 parts of galangal, 50 parts of fructus evodiae, 50 parts of cinnamomum burmannii bark and 50 parts of long pepper.
Example 3:
different from the examples 1-2, the material comprises the following raw materials in parts by weight: 70 parts of costustoot, 70 parts of fructus amomi, 100 parts of bighead atractylodes rhizome, 100 parts of dried orange peel, 100 parts of poria cocos, 100 parts of pinellia ternate, 70 parts of cyperus rotundus, 70 parts of immature bitter orange, 70 parts of cardamom, 70 parts of officinal magnolia bark with ginger, 70 parts of cablin potchouli herb, 30 parts of liquorice, 50 parts of Chinese date, 30 parts of galangal, 30 parts of evodia rutaecarpa, 30 parts of cinnamomum burmannii bark and 30 parts of long.
The stomach-nourishing pills prepared in the above examples 1-3 are respectively tested with a contrast group first-flavor sand stomach-nourishing pill, a contrast group second-flavor sand stomach-nourishing pill, a contrast group third-flavor sand stomach-nourishing pill, a contrast group fourth-flavor sand stomach-nourishing pill and a contrast group fifth-flavor sand stomach-nourishing pill, wherein the contrast group first-flavor sand stomach-nourishing pill is a common stomach-nourishing pill on the market, the contrast group second-flavor sand stomach-nourishing pill does not have galangal compared with the examples, the contrast group third-flavor sand stomach-nourishing pill does not have evodia compared with the examples, the contrast group fourth-flavor sand stomach-nourishing pill does not have long pepper compared with the examples, the contrast group fifth-flavor sand stomach-nourishing pill does not have yin-flavor skin compared with the examples, eight groups respectively use the stomach-nourishing pills prepared in the three examples and five contrast group stomach-flavor sand stomach-nourishing pills, and 30 patients in each group are selected, wherein 15 cases of men and women (no pregnant women) have dull pain in clinical manifestation, the greatest age of 65, The medicine is taken twice a day and 9g once for 9g each time, is tried out and investigated to obtain the following data, and the investigation result is shown in the table one:
table one:
as can be seen from the table I, the traditional Chinese medicine preparation for warming the middle-jiao and harmonizing the stomach comprises the following raw materials in proportion: 70 parts of costustoot, 70 parts of fructus amomi, 100 parts of bighead atractylodes rhizome, 100 parts of dried orange peel, 100 parts of poria cocos, 100 parts of pinellia ternate, 70 parts of cyperus rotundus, 70 parts of fructus aurantii immaturus, 70 parts of cardamom, 70 parts of cortex magnoliae officinalis, 70 parts of pogostemon cablin, 30 parts of liquorice, 50 parts of Chinese date, 30 parts of galangal, 30 parts of fructus evodiae, 30 parts of cinnamomum burmannii peel and 30 parts of long pepper, the effects of warming the middle-jiao and harmonizing the stomach are better, the drug effect is better exerted quickly, the waste of the medicinal materials can be avoided, the effects of treating gastric discomfort, discomfort in the epigastric region, vomiting acid water, upset discomfort, poor appetite and lassitude in the limbs are better, the raw materials in the embodiment 3 are combined into the preferable scheme of the invention, and the costustoot, fructus amomi, bighead atractylodes rhizome, dried orange peel, poria cocos, rhizoma cyperi, immature bitter orange fruit; galangal, which is hot in nature and pungent in flavor, enters spleen channel and stomach channel, is used for warming stomach, relieving vomit, dispelling cold and relieving pain, belongs to interior warming drugs, has the effects of resisting bacteria, relieving pain, resisting gastric ulcer, relieving diarrhea and benefiting gallbladder, and can delay the formation of thrombus and inhibit platelet aggregation; improving oxygen utilization capacity under low oxygen condition, and rhizoma Alpiniae Officinarum can be combined with pericarpium Citri Tangerinae and radix aucklandiae to enhance the effects of warming spleen and stomach; fructus evodiae, enter liver channel, spleen channel, stomach channel, kidney channel, dispel cold and relieve pain, check adverse rise of qi and arrest vomiting, assist yang and stop diarrhea, belong to warm the interior medicine, it has effects of invigorating stomach with aromatics, can dispel intestinal pneumatosis and inhibit intestinal abnormal fermentation, increase digestive juice secretion, inhibit gastrointestinal peristalsis and relieve spasm, antiemetic, and have pharmacological actions such as analgesia, gastric ulcer, lowering blood pressure, exciting uterus, antithrombotic formation, parasite killing, antibacterial, raising body temperature, protecting liver and benefiting gallbladder, inhibiting central nervous system, improving cardiovascular system function, antithrombotic, anti-anoxia, etc.; the yin-fragrant skin is warm in nature, pungent and sweet in taste, belongs to stomach channel, large intestine channel, liver channel and kidney channel, warms middle-jiao to relieve pain, dispels wind and removes cold, detoxifies and reduces swelling, and stops bleeding, belongs to interior-warming medicines, and is mainly used for treating cold stomachache, abdominal pain, diarrhea, inappetence, wind-cold-dampness arthralgia, lumbocrural pain, traumatic injury, traumatic hemorrhage, sore and furuncle pyogenic infections; long Pepper, warm the middle warmer and dispel cold, lower qi and relieve pain, belong to warm interior medicine, it is used for treating abdominal psychroalgia, emesis, diarrhea, migraine, the alcoholic extract has effects of antiulcer, anti-myocardial ischemia, the volatile oil can be anti-arrhythmic, regulate blood fat, and can inhibit central nerve, resist anoxia, calm, relieve pain, fever, broad spectrum antibacterial, have very strong relaxation effects on coronary vessel and smooth muscle of intestinal canal, etc.; can effectively enhance the effect of effective substances in the medicine and has better treatment effect.
Example 4
In the preferable technical scheme, the invention provides a traditional Chinese medicine preparation for warming middle-jiao and harmonizing stomach, which comprises the following raw materials in parts by weight: 70 parts of costustoot, 70 parts of fructus amomi, 100 parts of bighead atractylodes rhizome, 100 parts of dried orange peel, 100 parts of poria cocos, 100 parts of pinellia ternate, 70 parts of cyperus rotundus, 70 parts of immature bitter orange, 70 parts of cardamom, 70 parts of officinal magnolia bark with ginger, 70 parts of cablin potchouli herb, 30 parts of liquorice, 50 parts of Chinese date, 30 parts of galangal, 30 parts of evodia rutaecarpa, 30 parts of cinnamomum burmannii bark and 30 parts of long.
The costustoot, the fructus amomi, the bighead atractylodes rhizome, the dried orange peel, the poria cocos, the pinellia ternate, the cyperus rotundus, the immature bitter orange, the round cardamom, the ginger magnolia officinalis, the cablin potchouli herb, the liquorice, the Chinese date, the galangal, the evodia rutaecarpa, the cinnamomum burmannii bark and the long pepper are all products without plant diseases and insect pests, so that the safety of.
The pinellia ternate is prepared pinellia ternate, the cyperus rotundus is vinegar-fried cyperus rotundus, the immature bitter orange is bran-fried immature bitter orange, and the round cardamom is shelled.
The invention also provides a preparation method of the traditional Chinese medicine preparation for warming middle-jiao and harmonizing stomach, which comprises the following specific preparation steps:
the method comprises the following steps: weighing the costustoot, the villous amomum fruit, the largehead atractylodes rhizome, the tangerine peel, the Indian buead, the pinellia tuber, the cyperus rotundus, the immature bitter orange, the round cardamom, the officinal magnolia bark with ginger, the cablin potchouli herb, the liquoric root, the Chinese date, the galangal, the evodia rutaecarpa, the cinnamomum burmannii bark and;
step two: pulverizing radix aucklandiae, fructus Amomi, Atractylodis rhizoma, pericarpium Citri Tangerinae, Poria, rhizoma Pinelliae, rhizoma Cyperi, fructus Aurantii Immaturus, fructus Amomi rotundus, cortex Magnolia officinalis, herba Agastaches, Glycyrrhrizae radix, fructus Jujubae, rhizoma Alpiniae Officinarum, fructus evodiae, cortex Cinnamomi Burmannii and fructus Piperis Longi respectively, and sieving with 10-20 mesh sieve;
step three: performing steam distillation on pericarpium Citri Tangerinae, rhizoma Cyperi, fructus Aurantii Immaturus, cortex Magnolia officinalis, herba Agastaches and three-fourths of radix aucklandiae, rhizoma Alpiniae Officinarum, fructus evodiae, cortex Cinnamomi Burmannii and fructus Piperis Longi by weight to obtain volatile oil A and residue B;
step four: mixing the residue B with Atractylodis rhizoma, Poria, Glycyrrhrizae radix, fructus Jujubae, rhizoma Pinelliae (one fifth of the weight parts), the rest fructus evodiae and fructus Piperis Longi, decocting with water for three times (3 hr for the first time, 2 hr for the second time, and 1 hr for the third time), mixing decoctions, centrifuging, filtering to obtain residue C and filtrate, and concentrating the filtrate into soft extract D with relative density of 1.36-1.138(20 deg.C);
step four: soaking residue C, herba Agastaches, the rest radix aucklandiae, rhizoma Alpiniae Officinarum and cortex Cinnamomi Burmannii in 70% ethanol for 24 hr, percolating, collecting percolate, recovering ethanol, and concentrating under reduced pressure to obtain soft extract E with relative density of 1.36-1.38(20 deg.C);
step five: grinding fructus Amomi, fructus Amomi rotundus and the rest rhizoma Pinelliae, sieving with 300-400 mesh sieve, and mixing to obtain mixture F;
step six: mixing the substance volatile oil A, stirring and mixing the thick paste D and half of the mixture F by weight, gradually adding one third of the substance volatile oil A in the stirring process to obtain a mixture G, stirring and mixing the thick paste E and the rest mixture F, and gradually adding one third of the substance volatile oil A in the stirring process to obtain a mixture H;
step seven: and (3) uniformly stirring and mixing the mixture G and the mixture H, adding the residual volatile oil A in the stirring process, finally making pills, drying and polishing to obtain the stomach-nourishing xiangsha pills.
And cleaning, impurity removing and drying the costustoot, the villous amomum fruit, the largehead atractylodes rhizome, the tangerine peel, the Indian buead, the pinellia tuber, the cyperus rotundus, the immature bitter orange, the round cardamom, the ginger officinal magnolia bark, the cablin potchouli herb, the liquoric root, the Chinese date, the galangal, the medicinal evodia fruit, the cinnamomum burmannii bark and the long pepper before the step two, so that the cleanliness of.
The volatile oil A is stored in a sealed way, and meanwhile, the volatile oil A is subjected to sealing treatment in the mixing and adding process, so that the loss of the volatile oil can be avoided, and the effective components of the medicine can be ensured.
And in the fourth step, a reverse percolation method is adopted for percolation treatment, so that the percolation treatment effect is better.
Example 5
Different from the embodiment 4, in the sixth step, the thick paste D and the mixture F in half weight part are stirred and mixed, in the stirring process, the volatile oil a in half weight part is gradually added to obtain the mixture G, the thick paste E and the remaining mixture F are stirred and mixed, in the stirring process, the volatile oil a in the remaining part is gradually added to obtain the mixture H, then the mixture G and the mixture H are stirred and mixed uniformly, and finally, the mixture G and the mixture H are pelletized, dried and polished to obtain the stomach-nourishing xiangsha pills.
Example 6
Different from the embodiments 4 to 5, in the sixth step, the volatile oil A, the thick paste D, the thick paste E and the mixture F are directly stirred and mixed, and then the mixture is pelletized, dried and polished to obtain the stomach-nourishing xiangsha pills.
Taking the amomum villosum stomach-nourishing pills prepared in the embodiments 4-6, comparison six-spice-sand stomach-nourishing pills of a comparison group and seven-spice-sand stomach-nourishing pills of a comparison group to perform experiments, wherein the comparison six-spice-sand stomach-nourishing pills of the comparison group are prepared by extracting volatile oil A from all parts by weight of elecampane, galangal, evodia rutaecarpa, cinnamomum burmannii peel and long pepper in the third step, the comparison seven-spice-sand stomach-nourishing pills of the comparison group have no operation treatment in the second step, and after the first step, the subsequent treatment is directly performed; the stomach-nourishing pill prepared in the three embodiments, the stomach-nourishing pill of six fragrant sands in the control group and the stomach-nourishing pill of seven fragrant sands in the control group are respectively tried in five groups, 30 outpatients in each group are selected, wherein 15 men and 15 women (without pregnant women) are in the maximum age of 65 years and the minimum age of 20 years, clinically manifested as gastric pain hidden, epigastric discomfort, acid regurgitation, gastric upset discomfort, poor appetite and limb lassitude, and the pill is taken twice a day and 9g once, and is tried and investigated for a plurality of times to obtain the following data, and the investigation result is shown in the table two:
table two:
as can be seen from table two, in the process of preparing the xiangsha yangwei pill, when the preparation method in the fourth embodiment is the preferred scheme of the present invention, in the second step, various medicinal materials in the raw materials are respectively crushed, so that the particle size of the medicinal materials can be effectively reduced, the effects of volatile oil extraction, decoction and percolation treatment on the medicinal materials are better, the extraction of effective components in the medicinal materials is faster, in the third step, most of the medicinal materials in the raw materials are subjected to volatile oil extraction, the effective components of the volatile oil in the medicinal materials can be extracted, the drug effect can be ensured, meanwhile, most of the medicinal materials are provided with standby components, the standby components are added to the subsequent decoction and percolation treatment, so that the extraction of effective substances in the medicinal materials is more comprehensive, the effective components in the medicine can be better exerted, in the sixth step, the mixed powder F is divided into two parts, the two parts are respectively mixed with the thick paste D and, the two parts are mixed with the mixture F of the two parts, and the volatile oil A of each substance of the last part is added into the medicine in the last mixing process, so that the mixing effect of each substance and the materials can be effectively enhanced, the medicine mixing effect is better, the effect of effective substances in the medicine is better, and the treatment effect is better.
And finally: the above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that are within the spirit and principle of the present invention are intended to be included in the scope of the present invention.
Claims (10)
1. A traditional Chinese medicine preparation for warming middle-jiao and harmonizing stomach is characterized in that: the feed comprises the following raw materials in parts by weight: 50-90 parts of costustoot, 50-90 parts of fructus amomi, 70-130 parts of bighead atractylodes rhizome, 70-130 parts of dried orange peel, 70-130 parts of poria cocos, 70-130 parts of pinellia ternate, 50-90 parts of cyperus rotundus, 50-90 parts of immature bitter orange, 50-90 parts of round cardamom, 50-90 parts of ginger magnolia bark, 50-90 parts of patchouli, 10-50 parts of liquorice, 30-70 parts of Chinese date, 10-50 parts of galangal, 10-50 parts of fructus evodiae, 10-50 parts of cinnamomum burmannii bark and 10-50 parts of long pepper.
2. The traditional Chinese medicine preparation for warming the middle-jiao and harmonizing the stomach as claimed in claim 1, which is characterized in that: the feed comprises the following raw materials in parts by weight: 50 parts of costustoot, 50 parts of fructus amomi, 70 parts of bighead atractylodes rhizome, 70 parts of dried orange peel, 70 parts of poria cocos, 70 parts of pinellia ternate, 50 parts of cyperus rotundus, 50 parts of immature bitter orange, 50 parts of cardamom, 50 parts of officinal magnolia bark, 50 parts of cablin potchouli herb, 10 parts of liquorice, 30 parts of Chinese date, 10 parts of galangal, 10 parts of evodia rutaecarpa, 10 parts of cinnamomum burmannii bark and 10 parts of long pepper.
3. The traditional Chinese medicine preparation for warming the middle-jiao and harmonizing the stomach as claimed in claim 1, which is characterized in that: the feed comprises the following raw materials in parts by weight: 90 parts of costustoot, 90 parts of fructus amomi, 130 parts of bighead atractylodes rhizome, 130 parts of dried orange peel, 130 parts of poria cocos, 130 parts of pinellia ternate, 90 parts of cyperus rotundus, 90 parts of immature bitter orange, 90 parts of cardamom, 90 parts of cortex magnoliae officinalis, 90 parts of pogostemon cablin, 50 parts of liquorice, 70 parts of Chinese date, 50 parts of galangal, 50 parts of fructus evodiae, 50 parts of cinnamomum burmannii bark and 50 parts of long pepper.
4. The traditional Chinese medicine preparation for warming the middle-jiao and harmonizing the stomach as claimed in claim 1, which is characterized in that: the feed comprises the following raw materials in parts by weight: 70 parts of costustoot, 70 parts of fructus amomi, 100 parts of bighead atractylodes rhizome, 100 parts of dried orange peel, 100 parts of poria cocos, 100 parts of pinellia ternate, 70 parts of cyperus rotundus, 70 parts of immature bitter orange, 70 parts of cardamom, 70 parts of officinal magnolia bark with ginger, 70 parts of cablin potchouli herb, 30 parts of liquorice, 50 parts of Chinese date, 30 parts of galangal, 30 parts of evodia rutaecarpa, 30 parts of cinnamomum burmannii bark and 30 parts of long.
5. The traditional Chinese medicine preparation for warming the middle-jiao and harmonizing the stomach as claimed in claim 1, which is characterized in that: the costustoot, the fructus amomi, the bighead atractylodes rhizome, the dried orange peel, the poria cocos, the pinellia ternate, the cyperus rotundus, the immature bitter orange, the round cardamom, the ginger officinal magnolia bark, the patchouli, the liquorice, the Chinese date, the galangal, the evodia rutaecarpa, the cinnamomum burmannii bark and the long pepper are all products without plant diseases and insect pests.
6. The traditional Chinese medicine preparation for warming the middle-jiao and harmonizing the stomach as claimed in claim 1, which is characterized in that: the pinellia ternate is prepared pinellia ternate, the cyperus rotundus is vinegar-fried cyperus rotundus, the immature bitter orange is bran-fried immature bitter orange, and the round cardamom is shelled.
7. The method for preparing a Chinese medicinal preparation for warming the middle-jiao and harmonizing the stomach according to any one of claims 1 to 6, which is characterized in that: the preparation method comprises the following specific steps:
the method comprises the following steps: weighing the costustoot, the villous amomum fruit, the largehead atractylodes rhizome, the tangerine peel, the Indian buead, the pinellia tuber, the cyperus rotundus, the immature bitter orange, the round cardamom, the officinal magnolia bark with ginger, the cablin potchouli herb, the liquoric root, the Chinese date, the galangal, the evodia rutaecarpa, the cinnamomum burmannii bark and;
step two: pulverizing radix aucklandiae, fructus Amomi, Atractylodis rhizoma, pericarpium Citri Tangerinae, Poria, rhizoma Pinelliae, rhizoma Cyperi, fructus Aurantii Immaturus, fructus Amomi rotundus, cortex Magnolia officinalis, herba Agastaches, Glycyrrhrizae radix, fructus Jujubae, rhizoma Alpiniae Officinarum, fructus evodiae, cortex Cinnamomi Burmannii and fructus Piperis Longi respectively, and sieving with 10-20 mesh sieve;
step three: performing steam distillation on pericarpium Citri Tangerinae, rhizoma Cyperi, fructus Aurantii Immaturus, cortex Magnolia officinalis, herba Agastaches and three-fourths of radix aucklandiae, rhizoma Alpiniae Officinarum, fructus evodiae, cortex Cinnamomi Burmannii and fructus Piperis Longi by weight to obtain volatile oil A and residue B;
step four: mixing the residue B with Atractylodis rhizoma, Poria, Glycyrrhrizae radix, fructus Jujubae, rhizoma Pinelliae (one fifth of the weight parts), the rest fructus evodiae and fructus Piperis Longi, decocting with water for three times (3 hr for the first time, 2 hr for the second time, and 1 hr for the third time), mixing decoctions, centrifuging, filtering to obtain residue C and filtrate, and concentrating the filtrate into soft extract D with relative density of 1.36-1.138(20 deg.C);
step four: soaking residue C, herba Agastaches, the rest radix aucklandiae, rhizoma Alpiniae Officinarum and cortex Cinnamomi Burmannii in 70% ethanol for 24 hr, percolating, collecting percolate, recovering ethanol, and concentrating under reduced pressure to obtain soft extract E with relative density of 1.36-1.38(20 deg.C);
step five: grinding fructus Amomi, fructus Amomi rotundus and the rest rhizoma Pinelliae, sieving with 300-400 mesh sieve, and mixing to obtain mixture F;
step six: mixing the substance volatile oil A, stirring and mixing the thick paste D and half of the mixture F by weight, gradually adding one third of the substance volatile oil A in the stirring process to obtain a mixture G, stirring and mixing the thick paste E and the rest mixture F, and gradually adding one third of the substance volatile oil A in the stirring process to obtain a mixture H;
step seven: and (3) uniformly stirring and mixing the mixture G and the mixture H, adding the residual volatile oil A in the stirring process, finally making pills, drying and polishing to obtain the stomach-nourishing xiangsha pills.
8. The preparation method of the traditional Chinese medicine preparation for warming middle-jiao and harmonizing stomach as claimed in claim 7 is characterized in that: cleaning, impurity removing and drying costustoot, fructus amomi, bighead atractylodes rhizome, dried orange peel, poria cocos, pinellia ternate, cyperus rotundus, immature bitter orange, round cardamom, cortex magnoliae officinalis, cablin potchouli herb, liquorice, Chinese date, galangal, fructus evodiae, cinnamomum burmannii bark and long pepper before the second step.
9. The preparation method of the traditional Chinese medicine preparation for warming middle-jiao and harmonizing stomach as claimed in claim 7 is characterized in that: sealing and storing the volatile oil A, and sealing during the mixing and adding process of the volatile oil A.
10. The preparation method of the traditional Chinese medicine preparation for warming middle-jiao and harmonizing stomach as claimed in claim 7 is characterized in that: and percolating by countercurrent percolation.
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| CN113499406A (en) * | 2021-07-05 | 2021-10-15 | 衢州市王德裕堂国药有限公司 | Traditional Chinese medicine composition for nourishing stomach and slimming |
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Non-Patent Citations (1)
| Title |
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| 国家药典委员会: "《中华人民共和国药典：2010年版.一部》", 31 January 2010, 中国医药科技出版社 * |
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| CN113499406A (en) * | 2021-07-05 | 2021-10-15 | 衢州市王德裕堂国药有限公司 | Traditional Chinese medicine composition for nourishing stomach and slimming |
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