CN111904887A - Skin health care composition and application thereof in paper diapers - Google Patents

Skin health care composition and application thereof in paper diapers Download PDF

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Publication number
CN111904887A
CN111904887A CN202010934543.6A CN202010934543A CN111904887A CN 111904887 A CN111904887 A CN 111904887A CN 202010934543 A CN202010934543 A CN 202010934543A CN 111904887 A CN111904887 A CN 111904887A
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China
Prior art keywords
parts
extract
skin
powder
stirring
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Granted
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CN202010934543.6A
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CN111904887B (en
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鲍佳
金利伟
鲍益平
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Hangzhou Coco Healthcare Products Co Ltd
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Hangzhou Coco Healthcare Products Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37Esters of carboxylic acids
    • A61K8/375Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63Steroids; Derivatives thereof
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8105Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • A61K8/8111Homopolymers or copolymers of aliphatic olefines, e.g. polyethylene, polyisobutene; Compositions of derivatives of such polymers
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    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
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    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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    • A61K8/9783Angiosperms [Magnoliophyta]
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    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
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    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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    • A61L15/42Use of materials characterised by their function or physical properties
    • A61L15/44Medicaments
    • AHUMAN NECESSITIES
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    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • A61L15/46Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/02Local antiseptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005Antimicrobial preparations
    • AHUMAN NECESSITIES
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    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
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    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
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    • A61K2800/82Preparation or application process involves sonication or ultrasonication
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    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/22Lipids, fatty acids, e.g. prostaglandins, oils, fats, waxes
    • A61L2300/222Steroids, e.g. corticosteroids
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    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23Carbohydrates
    • A61L2300/232Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
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    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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    • A61L2300/252Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
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    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404Biocides, antimicrobial agents, antiseptic agents
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract

The invention relates to the field of sanitary external products, in particular to a skin sanitary nursing composition and application thereof in preparation of paper diapers. A skin hygiene care composition comprising by weight: 2-4 parts of yeast polypeptide freeze-dried powder, 1-3 parts of grapefruit seed extract, 1-6 parts of blueberry extract, 0.5-8 parts of caulis piperis longi extract, 1-2 parts of bletilla powder, 2.5-4 parts of sodium hyaluronate, 0.1-1.5 parts of menthyl lactate and 0.1-1.5 parts of hydrogenated polyisobutene. The natural active substance extracted from the composition and the yeast polypeptide have synergistic effect, and can play the roles of moisturizing skin, resisting bacteria, diminishing inflammation and the like, and eliminate or weaken red and swollen skin injury. The preparation prepared from the composition can not only form a natural barrier of skin, but also can prevent excrement from adhering to the skin, obviously improve smell, and has the effects of preventing and treating diaper rash and urethritis.

Description

Skin health care composition and application thereof in paper diapers
Technical Field
The invention relates to the field of sanitary external products, in particular to a skin sanitary nursing composition and application thereof in preparation of paper diapers.
Background
Along with the improvement of living standard of people, the use of disposable articles is more and more common, in particular to the application of paper diapers, the sales volume of the paper diapers for children or adults is increased year by year, but the long-term friction of the coating layer to the skin in the process of frequently putting on and taking off the paper diaper easily causes mechanical physical damage, meanwhile, as the basement membrane of the anti-leakage paper diaper is made of organic fiber materials, the local environment has higher temperature and humidity and bacteria are easy to propagate, particularly, urine and amino components in excrement easily cause skin microenvironment imbalance, blockage and damage to skin barriers, the epidermis of an infant is more easily affected by hydration and finally causes skin injuries such as diaper rash, the diaper rash is a common skin inflammatory lesion of the infant and is mostly generated by urine immersion stimulation and bacterial breeding in a humid environment, the lipid layer of the skin of the infant is damaged to aggravate local inflammatory reaction, red swelling and even ulceration are generated, and bacterial infection and general urethral diseases are caused more seriously.
In the prior art, the air permeability or the water absorption performance of absorbent resin of the surface layer of the paper diaper is improved, so that the dry, soft and water-guiding performance of the paper diaper is enhanced, and skin damage is avoided, or skin care ingredients, pH regulation and the like are added, for example, CN110946712A discloses an infant paper diaper which can play a role in nursing the hip-softening and fat-building, wherein the surface coating layer is provided with a surface layer and a flow guide layer, and the surface coating layer contains the skin care ingredients; the absorption core layer is added with pH control component, the skin care component contains alcohol formate, diglycerol, mefenamic acid, biguanide, aloe gel, vitamin E, citric acid, etc., and the pH control component and ammonia inhibiting component include ethanol ester and tea polyphenols. It is primarily intended to prevent skin irritation and diaper rash from occurring by controlling the pH. However, the addition of acidic components to change the pH may result in a change in the pH of the normal skin surface, and there is no additional benefit to the skin when used without urine and other fecal matter; in addition, it does not reduce harmful substances and adhesion of excrement itself and improve odor. The moisture content of the skin of infants is quite high, and can reach 40%, so that the skin of infants appears very young and tender, and skin diseases can occur when the moisture content of the horny layer is lower than 10%. Is sensitive to external stimulation, and natural moisturizing and allergy-relieving skin care products are more needed.
Disclosure of Invention
In order to solve the above technical problems, it is an object of the present invention to provide a skin hygiene care composition, which can achieve the effects of moisturizing skin, resisting bacteria, diminishing inflammation, etc., and eliminating or reducing skin red and swollen injuries through the synergistic effect of natural active substances extracted from the composition and yeast polypeptides. The preparation prepared from the composition can not only form a natural barrier of skin, but also can prevent excrement from adhering to the skin, obviously improve smell, and has the effects of preventing and treating diaper rash and urethritis.
In order to achieve the purpose, the invention adopts the following technical scheme:
a skin hygiene care composition comprising by weight: 2-4 parts of yeast polypeptide freeze-dried powder, 1-3 parts of grapefruit extract, 1-6 parts of blueberry extract, 0.5-8 parts of caulis piperis longi extract, 1-2 parts of bletilla powder, 2.5-4 parts of sodium hyaluronate, 0.1-1.5 parts of menthyl lactate and 0.1-1.5 parts of hydrogenated polyisobutene.
Preferably, the grapefruit extract is prepared by drying and pulverizing cleaned grapefruit peel and seed into coarse powder, adding 5-50 times of 70-95 deg.C hot water, ultrasonic extracting for 1-2 hr, repeating for 3 times, mixing extractive solutions, filtering, concentrating, and freeze drying to obtain grapefruit extract A component; adding the filter residues into 35-85% ethanol water solution, stirring and standing for 0.5-1h, filtering, extracting the filtrate, repeating for three times, mixing the filtrates, heating and concentrating, oven drying to obtain component B of grapefruit extract, and mixing the A, B components to obtain grapefruit extract powder.
Preferably, the blueberry extract extraction process comprises the following steps: taking blueberry fruits, fully crushing, and mixing with a volume fraction of 0.5% HCl and a 65-85% ethanol aqueous solution according to a mass-volume ratio of 1: 15, uniformly mixing, performing ultrasonic-assisted extraction at 30 ℃ for 30min, filtering the extracting solution, merging and collecting the filtrate, concentrating, and drying to obtain blueberry extract powder.
Preferably, the sargentgloryvine stem extract is prepared by washing sargentgloryvine stem, drying, then placing in a grinder for grinding, fully grinding in a grinding mill, adding into a Soxhlet extractor, adding an ethanol solution, heating and refluxing for 0.5-2h, collecting ethanol to obtain a sargentgloryvine stem extraction liquid, and performing spray drying or freeze drying on the liquid to obtain the sargentgloryvine stem extract powder.
Further, the present application provides a skin hygiene care formulation comprising the following components in the composition: 2-4 parts of yeast polypeptide freeze-dried powder, 1-3 parts of grapefruit extract, 1-6 parts of blueberry extract, 0.5-8 parts of caulis piperis longi extract, 1-2 parts of bletilla powder, 2.5-4 parts of sodium hyaluronate, 0.1-1.5 parts of menthyl lactate, 0.1-1.5 parts of hydrogenated polyisobutene, 0.2-1 part of hydrogenated lecithin, 0.1-2 parts of vitamin E acetate, 0.5-1 part of zinc oxide, 1.5-10 parts of sesame oil, 0.1-1 part of dipotassium glycyrrhizinate, 0.1-2 parts of surfactant, 0.1-0.2 part of preservative and 2-9 parts of deionized water.
Preferably, the preparation method of the preparation is as follows:
1) sequentially putting the menthyl lactate, the hydrogenated polyisobutene, the hydrogenated lecithin, the vitamin E acetate and the sesame oil in parts by weight into an emulsifying pot, uniformly mixing, adding the zinc oxide, and stirring at the temperature of 60-80 ℃ for 15-45 minutes to obtain a component A for mixing;
2) adding surfactant and sodium hyaluronate into deionized water, heating to 60-90 deg.C, stirring, mixing or sequentially adding rhizoma Bletillae powder, caulis Kadsurae Longipedunculatae extract powder, grapefruit extract powder, and blue extract powder, stirring for 15-30 min, adding dipotassium glycyrrhizinate, and stirring to obtain component B;
3) adding the component B into an emulsifying pot of the component A under the condition of heat preservation, homogenizing the bottom of the emulsifying pot at the rotating speed of 1500 rpm, stirring for 10-50 minutes at the temperature of 60-90 ℃ at the speed of a scraper in the emulsifying pot, naturally cooling to room temperature, sequentially adding the saccharomycete polypeptide freeze-dried powder and the preservative into the emulsifying pot, continuously stirring for 20 minutes, and uniformly mixing to obtain the yeast polypeptide emulsion.
Preferably, the surfactant is selected from one or more of dodecyl betaine, cetearyl glucoside and glycerol stearate; the preservative is selected from iodopropynyl butylcarbamate or bis (hydroxymethyl) imidazolidinyl urea.
Preferably, the composition can be prepared into the form of gel, spray, emulsion, cream or ointment, and can be directly applied to the skin surface or the bottom of the surface layer of a diaper.
Further, the application provides a liquid-permeable surface layer of the skin-care antibacterial paper diaper, which is made of a non-woven fabric material or a natural fiber material and contains the composition.
Further, the application provides a preparation method of the liquid-permeable surface layer of the skin-care antibacterial paper diaper, which uses a non-woven fabric material or a natural fiber material and is prepared by the following steps of respectively cleaning, drying, grinding and mixing 1-3 parts of grapefruit extract, 1-6 parts of blueberry extract and 0.5-8 parts of schisandra chinensis extract, adding 5-50 times of ethanol, stirring and adding 0.5-1 part of bletilla striata powder, carrying out ultrasonic treatment on the mixture at 40-80 ℃ for 0.5-1h, standing and recovering ethanol to obtain a plant extract, adding 2.5-4 parts of sodium hyaluronate, 0.1-1.5 parts of menthyl lactate and 0.1-1.5 parts of hydrogenated polyisobutene, adding deionized water, stirring and mixing uniformly to obtain a medicinal solution, using an impregnation method, immersing the non-woven fabric material or the natural fiber material into the solution, the mangle ratio is 30-40%, the temperature is 25-45 ℃, ultraviolet sterilization is carried out after 0.5-1h of treatment, 1-3 parts of yeast polypeptide freeze-dried powder are dissolved in deionized water with the concentration of 0.5g/100ml, and after uniform spraying, low-temperature drying and shaping are carried out, thus obtaining the liquid permeable surface layer of the paper diaper.
The plant extract in the present application can be prepared by a conventional process or purchased as a commercially available product, and is preferably prepared by the above-mentioned process. The blueberry extract contains a large amount of procyanidine substances, so that the bacterial adhesion is resisted, pathogenic bacteria such as escherichia coli and the like can be prevented from being adhered to epithelial cells of a urethra and the wall of a bladder, the pathogenic bacteria flow away along with urine, and the occurrence of urinary tract infection is prevented. It is known that grapefruit can nourish tissue cells, induce diuresis to reduce edema, resist bacteria and infection, condition mixed and oily skin which is easy to grow pox, deeply purify oily acne and hyperemic skin, promote hair growth and compact skin and tissue, and naringin contained in grapefruit extract has the functions of resisting inflammation, easing pain, resisting virus, inhibiting bacteria and the like. The caulis Kadsurae Longipedunculatae extract has effects of relieving swelling, eliminating dampness and resisting bacteria. Bletilla striata is slightly cold in nature and bitter and astringent in taste, enters lung channel, has the functions of astringing to stop bleeding, tonifying lung and promoting tissue regeneration, can reduce swelling and promote tissue regeneration, and is used for treating carbuncle, sore and toxin, and scald caused by water and fire.
The saccharomycete polypeptide as humectant and antisenility material is used in skin care product, and the application of the saccharomycete polypeptide in protecting diaper rash of infant paper diaper can improve the smell of excrement obviously, lower the sensitivity of skin to excrement and lower the incidence of diaper rash caused by combining the saccharomycete polypeptide with plant extract.
The invention has the beneficial effects that: the natural substances are used in combination, so that a natural protective barrier is formed on the surface layer of the skin, excrement is moderately isolated, bacteria and viruses can be resisted and inhibited, diseases such as diaper rash and urethritis are effectively prevented and treated, and the odor of the excrement is eliminated and improved. In the plant extract, the grapefruit and the blueberry contain antibacterial ingredients, so that the infection of germs can be inhibited to a greater extent, the anti-inflammation and analgesic effects are good, the caulis piperis kadsurae contains the antibacterial ingredients and can play a role in relieving skin redness and swelling, the bletilla can reduce swelling and promote tissue regeneration and can improve the stability of polypeptide substances, the yeast polypeptide obviously improves the taste of excrement and synergistically enhances the antibacterial effect of the plant extract, and the plant extract is free of irritation and skin sensitivity. After the preparation prepared from the composition is used for integrating the surface layer of the paper diaper, the probability of diaper rash and complications thereof is obviously reduced, the condition of adhesion of skin excrement is reduced, and odor is weakened or even eliminated, so that the skin is easier to keep clean and fresh. Sodium hyaluronate is used as one of natural moisturizing factors of skin, moisturizes, absorbs water, resists static electricity, menthyl lactate has a cool skin feeling after being used, and hydrogenated polyisobutene is also called shark oil and has skin lipophilicity. The dipotassium glycyrrhizinate has multiple effects of bacteriostasis, inflammation diminishing, detoxification, anti-allergy, deodorization and the like. Has wide application in the industries of medicine, cosmetics, daily chemicals, food and the like. The skin health care preparation prepared by the auxiliary materials is easy to spread and is mild and isolated when being used as a skin care health care product.
Detailed Description
The invention is further illustrated by the following specific examples.
Example 1 preparation of extract of raw materials
The plant extracts of the present invention can be prepared using commercially available raw materials or by conventional methods, preferably by the following processes: drying and pulverizing cleaned grapefruit peel and seed into coarse powder, adding 5-50 times of 70-95 deg.C hot water, ultrasonically extracting for 1-2h, repeating for 3 times, mixing extractive solutions, filtering, concentrating, and freeze drying to obtain grapefruit extract A component; adding the filter residues into 35-85% ethanol water solution, stirring and standing for 0.5-1h, filtering, extracting the filtrate, repeating for three times, mixing the filtrates, heating and concentrating, oven drying to obtain component B of grapefruit extract, and mixing the A, B components to obtain grapefruit extract powder. Taking blueberry fruits, fully crushing, and mixing with a volume fraction of 0.5% HCl and a 65-85% ethanol aqueous solution according to a mass-volume ratio of 1: 15, uniformly mixing, performing ultrasonic-assisted extraction at 30 ℃ for 30min, filtering the extracting solution, merging and collecting the filtrate, concentrating, and drying to obtain blueberry extract powder. Cleaning caulis Kadsurae Longipedunculatae, drying, pulverizing in a pulverizer, grinding in a mill, adding into a Soxhlet extractor, adding ethanol solution, heating and refluxing for 0.5-2h, collecting ethanol to obtain extractive solution, and spray drying or freeze drying to obtain caulis Kadsurae Longipedunculatae extract powder.
The yeast polypeptide is obtained from Guangdong Jinbaolai Biotech, and is lyophilized by conventional method, such as selecting purified water, deionized water, osmotic water and distilled water, etc. to adjust the concentration of yeast polypeptide to be
Figure BDA0002671464840000041
The polypeptide solution of (4); homogenizing with a high-speed homogenizer at a controlled rotation speed of
Figure BDA0002671464840000042
The treatment time is
Figure BDA0002671464840000043
Obtaining homogenized solution, transferring into freezing tray for pre-freezing at pre-freezing temperature
Figure BDA0002671464840000044
The pre-freezing time is
Figure BDA0002671464840000045
Then placing the mixture in a freezing bin of a vacuum freezing dryer, controlling the vacuum degree to be less than l0Pa, and carrying out vacuum freezing drying for the time
Figure BDA0002671464840000046
Thus obtaining the yeast polypeptide freeze-dried powder.
Example 2 preparation of solutions, gels and emulsions, respectively
Solution preparation: taking 3g of yeast polypeptide freeze-dried powder, 2g of grapefruit extract powder, 4g of blueberry extract powder, 4g of kadsura pepper stem extract powder, 1g of bletilla striata powder, 3g of sodium hyaluronate, 0.7g of menthyl lactate and 0.7g of hydrogenated polyisobutene. Adding the plant extract and the polypeptide freeze-dried powder into an organic phase: the water phase is 20: and (4) stirring the mixed solution of 80-40:60, wherein the organic phase is ethanol or acetone, and the water phase is deionized water or distilled water to obtain the mixed solution.
Preparing a gel agent: adding the mixed solution into transparent chitosan hydrogel or sodium alginate hydrogel, shaking in a shaking table, and adding dipotassium glycyrrhizinate 0.7g and antiseptic 0.1g to obtain hydrogel preparation of the composition.
Preparing an emulsion: sequentially putting 0.7g of menthyl lactate, 0.7g of hydrogenated polyisobutene, 0.7g of hydrogenated lecithin, 1g of vitamin E acetate and 8g of sesame oil into an emulsifying pot, uniformly mixing, then putting 0.7g of zinc oxide, and stirring for 15-45 minutes at 70 ℃ to obtain a component A for mixing; adding 1g of dodecyl betaine and 3g of sodium hyaluronate into deionized water, heating to 80 ℃, stirring, mixing or sequentially adding 1.5g of bletilla striata powder, 2g of caulis piperis longi extract powder, 1.5g of grapefruit extract powder and 5.5g of blueberry extract powder, stirring for 20 minutes, adding 1g of dipotassium glycyrrhizinate, uniformly stirring to obtain a component B, mixing the component B under the condition of heat preservation to obtain a component B, adding the component B into an emulsion pot of the component A, homogenizing the bottom of the emulsion pot at 1500 revolutions per minute, scraping plates in the emulsion pot at 30 revolutions per minute and 60-90 ℃, stirring for 10-50 minutes, naturally cooling to room temperature, sequentially adding 2g of yeast polypeptide freeze-dried powder, 0.1g of iodopropynyl butylcarbamate and 0.1g of bis (hydroxymethyl) imidazolidinyl urea into the emulsion pot, continuously stirring for 20 minutes, and uniformly mixing to obtain the composition.
Example 3 safety test
Hydrogel/emulsion and solution formulations prepared from the skin hygiene care compositions described in the examples of the invention were tested separately, with warm water for the control group. 30 young mice are used and divided into three groups, and the health meets the test requirements. Respectively testing the hydrogel/emulsion and the solution preparation, performing control and test by using autologous left and right depilatory skin, smearing the preparation on the depilatory skin on the other side of the depilatory skin only by using warm water on the control side once a day, cleaning after 12h, and continuing to smear for 7 days continuously. And (6) observing the result.
The results show that all the white mice tested have no skin allergy stress reaction, no toxicity discomfort reaction, normal physiological activity performance, and the preparation prepared by the composition has no skin irritation and toxicity.
Example 4 preparation of liquid-permeable surface layer of skin-protecting antibacterial paper diaper
Using a non-woven fabric material, taking grapefruit peel and seeds 5g, blueberry 5g and caulis schisandrae, respectively cleaning, drying, crushing and grinding, mixing, adding 500 ml of 60% ethanol, stirring, adding bletilla striata powder 2g, performing ultrasonic treatment on the mixture for 0.5h at 70 ℃, standing, recovering ethanol to obtain a plant extract, adding sodium hyaluronate 4g, menthyl lactate 1.5g and hydrogenated polyisobutene 1.5g, adding deionized water until stirring and mixing uniformly to obtain a medicinal solution, using an impregnation method, immersing the non-woven fabric material or a natural fiber material into the solution, treating at 35 ℃ for 0.5h, performing ultraviolet disinfection, dissolving yeast polypeptide freeze-dried powder 4g in deionized water, wherein the concentration is 0.5g/100ml, uniformly spraying, and drying and shaping at low temperature to obtain a liquid permeable surface layer of the paper diaper.
Example 5 antimicrobial testing
Experimental group 1: the liquid-permeable top layer containing the preparation of the invention prepared in example 4 was cut into 10 × 10cm square pieces, 20mL of physiological saline was poured, and after complete absorption, the liquid-permeable top layer was placed in a closed environment (37 ℃, relative humidity of 75%) in which an open-cell cultured E.coli culture and a Streptococcus culture were placed.
Experimental group 2: the nonwoven material was cut into 10 × 10cm square pieces, the emulsion prepared in example 2 was applied, 20mL of physiological saline was poured, and after complete absorption, the mixture was placed in a closed environment (37 ℃, relative humidity of 75%), and the open culture of escherichia coli and streptococcus was placed in the closed environment.
Experimental group 3: the nonwoven material was cut into 10 × 10cm square pieces, applied with the hydrogel prepared in example 2, poured with 20mL of physiological saline, placed in a closed environment (37 ℃, relative humidity 75%) after complete absorption, and the open culture of escherichia coli and streptococcus was placed in the closed environment.
Experimental group 4: the nonwoven material was cut into 10 × 10cm square pieces, smeared with the emulsion prepared in example 2, but not containing the yeast polypeptide lyophilized powder, poured with 20mL of physiological saline, placed in a closed environment (37 ℃, relative humidity of 75%) after it was completely absorbed, and placed in the closed environment with the open culture of escherichia coli and streptococcus culture.
Experimental group 5: the non-woven material was cut into 10 × 10cm square pieces, coated with the emulsion prepared in example 2, but not with the addition of the extract of caulis piperis longi, grapefruit, and blueberry, poured in 20mL of physiological saline, placed in a closed environment (37 ℃, relative humidity 75%) after complete absorption, and placed in the closed environment with the culture of escherichia coli and the culture of streptococcus under open culture.
Control group: the non-woven fabric material is cut into 10 × 10cm square pieces, 20mL of physiological saline is poured, after the physiological saline is completely absorbed, the non-woven fabric material is placed in a closed environment (37 ℃, the relative humidity is 75%), and an open culture of escherichia coli and a culture of streptococcus are placed in the closed environment.
After the experimental group and the control group are respectively placed for 20min, 3h and 7h, the colony count (CFU/mL) on the paper diapers of the experimental group and the control group is measured, the specific measurement method is that the non-woven fabric material is cut into pieces and then is dispersed in 50mL of deionized water, the soaked and filtered, 1mL of sample is taken to be cultured in an incubator (37 ℃) for 48h, the total number of the colonies is measured, and the average value is taken in 5 batches of tests. The test results are shown in Table 1
Figure BDA0002671464840000061
It can be seen that, along with the increase of time, the antibacterial performance of the solution/emulsion/gel preparation prepared from the composition in the experimental group gradually appears, while the antibacterial performance of the control group is poor, and along with the increase of time, the number of bacterial colonies increases, wherein the antibacterial effect of the emulsion group is the best, in addition, the experimental groups 4 and 5 prove that the components have synergistic effect, and the combined use of the saccharomycete polypeptide and the plant extract can exert the drug effect to the maximum extent, so that the paper diaper and the preparation prepared by the invention have good antibacterial performance.
EXAMPLE 6 deodorizing Effect
Taking paper diapers of the same brand, cutting the paper diapers into square pieces of 15 x 15cm, putting the square pieces into a sealing box for fixing, and dividing the paper diapers into two groups, wherein the emulsion prepared in the embodiment 2 of the invention is completely coated on one group of the paper diapers, and the extract group is the emulsion prepared in the embodiment 2, but does not contain saccharomycete polypeptide; the yeast polypeptide group was the emulsion prepared in the method of example 2 but did not contain the step of adding the extracts of kadsura pepper stem, grapefruit and blueberry, and the other blank group was not coated with any preparation. Odorous substances are injected through the needle holes of the box cover, the odorous substances are three groups, one group is urine and excrement mixed liquor, the other group is female physiological secretion, and the other group is provided with a control group and adopts distilled water. The three groups of samples are placed in an environment with room temperature and 40% humidity, 10ml of the samples are extracted after the samples are placed for 4-5 hours, and the injection needle tubes are injected into the samples and the blank group of closed boxes. Adopting a sensory evaluation method, opening the box body by 10-20 testers under the double-blind condition, carrying out smell-smelling scoring within a distance of 5cm, testing each sample for 3 times, and taking an average value. The degree of malodor is calculated using the score. 5: strong malodor; 4: strong odor; 3: unpleasant odors that are easily smelled; 2: a tolerable odor; 1: a weak taste; 0: without any taste. The measurement evaluation was performed 5min, 30min and 50min after the sample injection. The extract group and the yeast polypeptide group were evaluated after 50 min.
Figure BDA0002671464840000071
It can be seen that the deodorizing effect of the preparation is better as the odor degree is lower with the time, probably due to the composition having inhibitory effect on urease in the excrement or due to the decrease of odor-causing substances in the excrement, the deodorizing effect of the yeast polypeptide is remarkable, and the extract group may eliminate a small amount of odor by the effect of inhibiting bacteria.
Example 7 skin Effect test
A commercially available ordinary diaper was selected, the test subjects were infants aged 0-2 years with a history of diaper rash, the test groups were applied with the emulsion described in example 2 of the present invention, the control group was applied with the ordinary diaper rash cream, and the blank group was applied without any formulation. No antiallergic agent or external preparation is used 24 hours before use. Using a multicenter randomized controlled study, 15 each of the test/control/blank groups were compared for 7 days with the emulsion of example 2/hospital normal cream and without any formulation, two coating observations per day.
Group of Visibly apparent adherent feces to the skin Visible red spots Red swelling appears Pimple Ulceration with infection
Test group 1 0 0 0 0
Control group 8 5 2 1 0
Blank group 15 11 11 6 2
The test result of the baby shows that: the composition preparation can improve the condition of adhering excrement to the skin, so that the skin is cleaner and drier, and the diaper rash symptoms and the skin damage condition are better than those of the common diaper rash cream in hospitals.
According to the test results, the composition has a synergistic effect, has a good effect of protecting and isolating skin, and not only improves the adhesion of excrement and eliminates the odor of the excrement after being coated, but also has the effects of natural antibiosis, bacteriostasis, skin care and allergy relief. The skin has improved dry and comfortable feeling, the yeast polypeptide not only improves the taste of excrement, but also enhances the antibacterial effect of the plant extract, and the combined use of the plant extract inhibits the breeding of bacteria, and has no irritation and skin sensitivity. After the whole surface layer of the paper diaper prepared by the method is used, diaper rash and complications thereof are obviously reduced, odor disappears, and the skin is easier to keep a healthy and clean state.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention, including any reference to the above-mentioned embodiments. Various modifications to these embodiments will be readily apparent to those skilled in the art. The general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims (10)

1. A skin hygiene care composition characterized by comprising the following components by weight: 2-4 parts of yeast polypeptide freeze-dried powder, 1-3 parts of grapefruit extract, 1-6 parts of blueberry extract, 0.5-8 parts of caulis piperis longi extract, 1-2 parts of bletilla powder, 2.5-4 parts of sodium hyaluronate, 0.1-1.5 parts of menthyl lactate and 0.1-1.5 parts of hydrogenated polyisobutene.
2. The skin hygiene care composition according to claim 1, wherein the grapefruit extract is obtained by drying and pulverizing cleaned grapefruit peel and seeds into coarse powder, adding 5-50 times of 70-95 ℃ hot water, performing ultrasonic extraction for 1-2h, repeating for 3 times, combining the extracts, filtering, concentrating, and freeze-drying to obtain a grapefruit extract A component; adding the filter residues into 35-85% ethanol water solution, stirring and standing for 0.5-1h, filtering, extracting the filtrate, repeating for three times, mixing the filtrates, heating and concentrating, oven drying to obtain component B of grapefruit extract, and mixing the A, B components to obtain grapefruit extract powder.
3. The skin hygiene care composition according to claim 1, wherein the blueberry extract is extracted by the following process: taking blueberry fruits, fully crushing, and mixing with a volume fraction of 0.5% HCl and a 65-85% ethanol aqueous solution according to a mass-volume ratio of 1: 15, uniformly mixing, performing ultrasonic-assisted extraction at 30 ℃ for 30min, filtering the extracting solution, combining the filtering solutions, collecting the filtrate, concentrating, and drying to obtain blueberry extract powder.
4. The skin hygiene care composition according to claim 1, wherein the caulis Kadsurae Longipedunculatae extract is prepared by washing caulis Kadsurae Longipedunculatae, drying, pulverizing in a pulverizer, grinding thoroughly in a mill, adding into a Soxhlet extractor, adding ethanol solution, heating under reflux for 0.5-2h, collecting ethanol to obtain caulis Kadsurae Longipedunculatae extract liquid, and spray drying or freeze drying to obtain caulis Kadsurae Longipedunculatae extract powder.
5. A skin hygiene care formulation comprising the composition of claim 1 and, as components: 2-4 parts of yeast polypeptide freeze-dried powder, 1-3 parts of grapefruit extract, 1-6 parts of blueberry extract, 0.5-8 parts of caulis piperis longi extract, 1-2 parts of bletilla powder, 2.5-4 parts of sodium hyaluronate, 0.1-1.5 parts of menthyl lactate, 0.1-1.5 parts of hydrogenated polyisobutene, 0.2-1 part of hydrogenated lecithin, 0.1-2 parts of vitamin E acetate, 0.5-1 part of zinc oxide, 1.5-10 parts of sesame oil, 0.1-1 part of dipotassium glycyrrhizinate, 0.1-2 parts of surfactant, 0.1-0.2 part of preservative and 2-9 parts of deionized water.
6. The formulation of claim 5, wherein the formulation is prepared by the following method:
sequentially putting the menthyl lactate, the hydrogenated polyisobutene, the hydrogenated lecithin, the vitamin E acetate and the sesame oil in parts by weight into an emulsifying pot, uniformly mixing, adding the zinc oxide, and stirring at the temperature of 60-80 ℃ for 15-45 minutes to obtain a component A for mixing;
adding surfactant and sodium hyaluronate into deionized water, heating to 60-90 deg.C, stirring, mixing or sequentially adding rhizoma Bletillae powder, caulis Kadsurae Longipedunculatae extract powder, grapefruit extract powder, and blue extract powder, stirring for 15-30 min, adding dipotassium glycyrrhizinate, and stirring to obtain component B;
adding the component B into an emulsifying pot of the component A under the condition of heat preservation, homogenizing the bottom of the emulsifying pot at the rotating speed of 1500 rpm, stirring for 10-50 minutes at the temperature of 60-90 ℃ at the speed of a scraper in the emulsifying pot, naturally cooling to room temperature, sequentially adding the saccharomycete polypeptide freeze-dried powder and the preservative into the emulsifying pot, continuously stirring for 20 minutes, and uniformly mixing to obtain the yeast polypeptide emulsion.
7. A formulation as claimed in claims 5 to 6 wherein said surfactant is selected from one or more of dodecyl betaine, cetearyl glucoside, glyceryl stearate; the preservative is selected from iodopropynyl butylcarbamate or bis (hydroxymethyl) imidazolidinyl urea.
8. The composition as claimed in claim 1, wherein the composition is prepared in the form of a gel, spray, emulsion, cream or ointment to be applied directly to the skin surface or to the bottom of the top layer of a diaper.
9. A skin-protecting antibacterial paper diaper, which is characterized in that the liquid-permeable surface layer of the paper diaper is made of a non-woven fabric material or a natural fiber material and contains the composition of claim 1.
10. The method for preparing a skin-protecting and antibacterial diaper according to claim 9, wherein a non-woven fabric material or a natural fiber material is used, and the diaper is prepared by washing, drying, grinding and mixing 1 to 3 parts of grapefruit extract, 1 to 6 parts of blueberry extract and 0.5 to 8 parts of wuxiangxue vine extract, adding 5 to 50 times of ethanol, stirring and adding 0.5 to 1 part of bletilla striata powder, subjecting the mixture to ultrasonic treatment at 40 to 80 ℃ for 0.5 to 1 hour, standing and recovering ethanol to obtain a plant extract, adding 2.5 to 4 parts of sodium hyaluronate, 0.1 to 1.5 parts of menthyl lactate and 0.1 to 1.5 parts of hydrogenated polyisobutene, adding deionized water, stirring and mixing uniformly to obtain a medicinal solution, using an impregnation method, immersing the non-woven fabric material or the natural fiber material in the solution, the mangle ratio is 30-40%, the temperature is 25-45 ℃, ultraviolet sterilization is carried out after 0.5-1h of treatment, 1-3 parts of yeast polypeptide freeze-dried powder are dissolved in deionized water with the concentration of 0.5g/100ml, and after uniform spraying, low-temperature drying and shaping are carried out, thus obtaining the liquid permeable surface layer of the paper diaper.
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