CN111840406A - 作用于干燥综合征的清润口腔喷雾剂及其制备方法 - Google Patents
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Abstract
本发明公开了作用于干燥综合征的清润口腔喷雾剂及其制备方法,该清润口腔喷雾剂按重量比分,包括以下组成:乌梅30g‑40g、甘草6g‑9g、生地15g‑20g、青果10g‑15g,以乌梅为主加青果、生地、甘草,方中乌梅与甘草合用,酸甘化阴以生津液,青果、生地清热养阴生津。且喷雾剂可直接作用于口腔的分泌腺,增加局部作用时间及有效药量,促进唾液分泌,乌梅和甘草配伍具有促进损伤的颌下腺细胞增殖的作用。
Description
技术领域
本发明涉及喷雾剂相关制品领域,具体为作用于干燥综合征的清润口腔喷雾剂及其制备方法。
背景技术
目前发病机制尚不十分明确,是一种发病率高,可波及各个年龄组的疾病。我国的患病率为0.29%-0.77%,老年人群中的患病率为3%-4%。本病女性多见,男女比为1:9-1:20。发病年龄多在40-50岁,也可见于儿童。口干燥症作为SS的诊断标准之一,是困扰患者的主要症状。临床上70%—80%的患者诉有口干,严重者因口腔粘膜、牙齿和舌发粘以致在讲话时需频频饮水,吞咽干性食物时需用水辅助,有时需夜间起床饮水,严重影响患者的生活质量,目前中药喷雾剂在治疗干燥综合征口干症状方面的产品研究尚属空白,因此,针对此类药物的研发有很大的市场空间和临床需求。
发明内容
本发明的目的在于提供作用于干燥综合征的清润口腔喷雾剂及其制备方法,以解决上述背景技术中提出的问题。
为实现上述目的,本发明提供如下技术方案:作用于干燥综合征的清润口腔喷雾剂,该清润口腔喷雾剂按重量比分,包括以下组成:乌梅30g-40g、甘草6g-9g、生地15g-20g、青果10g-15g。
优选的,该清润口腔喷雾剂按重量比分,包括以下组成:乌梅30g、甘草6g、生地15g、青果10g。
优选的,该清润口腔喷雾剂按重量比分,包括以下组成:乌梅40g、甘草9g、生地20g、青果15g。
作用于干燥综合征的清润口腔喷雾剂的制备方法, 包括以下步骤:
步骤1,原料选备:正规市场采购品质较高的乌梅、甘草、生地、青果,并根据各组分所需量,使用电子秤对各组分进行称取,备用;
步骤2,粉碎:将步骤1中称取后的乌梅、甘草、生地、青果通过粉碎机进行粉碎,粉碎至20-50目,将粉碎后的原料取出备用;
步骤3,基液制备,将步骤2中粉碎后的原料置入容器内,倒入温水进行浸泡,水温为35℃,浸泡时间为60min,浸泡完成后通过超声波进行反复提取,制得基液备用;
步骤4,过滤:将步骤3中的基液进行过滤,除去药渣,并将过滤得到的提取液进行浓缩处理;
步骤5,杀菌处理:将步骤4中冷却后的浓缩液通过巴氏杀菌机进行杀菌处理;
步骤6,灌装:将杀菌后的成品浓缩液通过喷雾剂灌装机灌装到喷雾剂瓶中。
与现有技术相比,本发明的有益效果是:
该作用于干燥综合征的清润口腔喷雾剂及其制备方法,以乌梅为主加青果、生地、甘草,方中乌梅与甘草合用,酸甘化阴以生津液,青果、生地清热养阴生津。且喷雾剂可直接作用于口腔的分泌腺,增加局部作用时间及有效药量,促进唾液分泌,乌梅和甘草配伍具有促进损伤的颌下腺细胞增殖的作用。青果具有清热、生津、利咽、祛痰的功效,常用于治疗咽喉肿痛、咳嗽、烦渴等症状。青果中亦含有丰富的有机酸,主要成分为苹果酸,其次为柠檬酸、酒石酸、奎宁酸、草酸,以及少量的富马酸和乙酸,可以增加唾液分泌,起到助消化的作用。生地性寒、味甘,具有清热养阴生津之功效,地黄的有效成分甾醇类可以使亢进的体液免疫下降,起到免疫调节的作用,可从整体上缓解干燥综合征病情。且本品携带方便,药物直接作用于局部,增加局部作用时间及有效药量,促进唾液分泌,达到缓解干燥综合征口干的目的。
附图说明
图1为本发明的作用于干燥综合征的清润口腔喷雾剂制备方法流程图。
具体实施方式
下面将结合本发明实施例中的附图,对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。
请参阅图1本发明提供的一种实施例:
实施例1
作用于干燥综合征的清润口腔喷雾剂,该清润口腔喷雾剂按重量比分,包括以下组成:乌梅30g、甘草6g、生地15g、青果10g。
作用于干燥综合征的清润口腔喷雾剂的制备方法,包括以下步骤:
步骤1,原料选备:正规市场采购品质较高的乌梅、甘草、生地、青果,并根据各组分所需量,使用电子秤对各组分进行称取,备用;
步骤2,粉碎:将步骤1中称取后的乌梅、甘草、生地、青果通过粉碎机进行粉碎,粉碎至20-50目,将粉碎后的原料取出备用;
步骤3,基液制备,将步骤2中粉碎后的原料置入容器内,倒入温水进行浸泡,水温为35℃,浸泡时间为60min,浸泡完成后通过超声波进行反复提取,制得基液备用;
步骤4,过滤:将步骤3中的基液进行过滤,除去药渣,并将过滤得到的提取液进行浓缩处理;
步骤5,杀菌处理:将步骤4中冷却后的浓缩液通过巴氏杀菌机进行杀菌处理;
步骤6,灌装:将杀菌后的成品浓缩液通过喷雾剂灌装机灌装到喷雾剂瓶中。
请参阅图1本发明提供的一种实施例:
实施例2
作用于干燥综合征的清润口腔喷雾剂,该清润口腔喷雾剂按重量比分,包括以下组成:乌梅40g、甘草9g、生地20g、青果15g。
作用于干燥综合征的清润口腔喷雾剂的制备方法,包括以下步骤:
步骤1,原料选备:正规市场采购品质较高的乌梅、甘草、生地、青果,并根据各组分所需量,使用电子秤对各组分进行称取,备用;
步骤2,粉碎:将步骤1中称取后的乌梅、甘草、生地、青果通过粉碎机进行粉碎,粉碎至20-50目,将粉碎后的原料取出备用;
步骤3,基液制备,将步骤2中粉碎后的原料置入容器内,倒入温水进行浸泡,水温为35℃,浸泡时间为60min,浸泡完成后通过超声波进行反复提取,制得基液备用;
步骤4,过滤:将步骤3中的基液进行过滤,除去药渣,并将过滤得到的提取液进行浓缩处理;
步骤5,杀菌处理:将步骤4中冷却后的浓缩液通过巴氏杀菌机进行杀菌处理;
步骤6,灌装:将杀菌后的成品浓缩液通过喷雾剂灌装机灌装到喷雾剂瓶中。
对于本领域技术人员而言,显然本发明不限于上述示范性实施例的细节,而且在不背离本发明的精神或基本特征的情况下,能够以其他的具体形式实现本发明。因此,无论从哪一点来看,均应将实施例看作是示范性的,而且是非限制性的,本发明的范围由所附权利要求而不是上述说明限定,因此旨在将落在权利要求的等同要件的含义和范围内的所有变化囊括在本发明内。不应将权利要求中的任何附图标记视为限制所涉及的权利要求。
Claims (4)
1.作用于干燥综合征的清润口腔喷雾剂,其特征在于:该清润口腔喷雾剂按重量比分,包括以下组成:乌梅30g-40g、甘草6g-9g、生地15g-20g、青果10g-15g。
2.根据权利要求1所述的作用于干燥综合征的清润口腔喷雾剂,其特征在于:该清润口腔喷雾剂按重量比分,包括以下组成:乌梅30g、甘草6g、生地15g、青果10g。
3.根据权利要求1所述的作用于干燥综合征的清润口腔喷雾剂,其特征在于:该清润口腔喷雾剂按重量比分,包括以下组成:乌梅40g、甘草9g、生地20g、青果15g。
4.作用于干燥综合征的清润口腔喷雾剂的制备方法,其特征在于,包括以下步骤:
步骤1,原料选备:正规市场采购品质较高的乌梅、甘草、生地、青果,并根据各组分所需量,使用电子秤对各组分进行称取,备用;
步骤2,粉碎:将步骤1中称取后的乌梅、甘草、生地、青果通过粉碎机进行粉碎,粉碎至20-50目,将粉碎后的原料取出备用;
步骤3,基液制备,将步骤2中粉碎后的原料置入容器内,倒入温水进行浸泡,水温为35℃,浸泡时间为60min,浸泡完成后通过超声波进行反复提取,制得基液备用;
步骤4,过滤:将步骤3中的基液进行过滤,除去药渣,并将过滤得到的提取液进行浓缩处理;
步骤5,杀菌处理:将步骤4中冷却后的浓缩液通过巴氏杀菌机进行杀菌处理;
步骤6,灌装:将杀菌后的成品浓缩液通过喷雾剂灌装机灌装到喷雾剂瓶中。
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113230327A (zh) * | 2021-06-24 | 2021-08-10 | 杭州市中医院 | 一种用于缓解透析患者口渴的中药制剂及其制备方法 |
CN114504628A (zh) * | 2022-02-23 | 2022-05-17 | 中南大学湘雅二医院 | 一种用于术后口渴患者的口腔喷雾 |
-
2020
- 2020-08-24 CN CN202010858747.6A patent/CN111840406A/zh active Pending
Non-Patent Citations (2)
Title |
---|
任君: "《家庭保健冷食谱》", 31 August 1993, 上海中医学院出版社 * |
王谨等: "乌梅含漱液与喷雾剂对健康人唾液腺分泌影响的对比分析", 《全科护理》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113230327A (zh) * | 2021-06-24 | 2021-08-10 | 杭州市中医院 | 一种用于缓解透析患者口渴的中药制剂及其制备方法 |
CN114504628A (zh) * | 2022-02-23 | 2022-05-17 | 中南大学湘雅二医院 | 一种用于术后口渴患者的口腔喷雾 |
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