CN106890215A - 一种纯中药口腔护理液及其制备工艺 - Google Patents
一种纯中药口腔护理液及其制备工艺 Download PDFInfo
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Abstract
本发明公开了一种纯中药口腔护理液，本发明屏弃传统上制备口腔护理液的技术方案，采用全新的、纯绿色的制备方法。此口腔护理液不添对人体有害的冰片、香精、甲硝唑、双氧水、水杨酸甲酯、氟化物及一些抗菌剂、甜味剂等一些化学类成分，仅将一定份数的金银花、地椒、罗勒、野菊花的提取物和一定份数的纯净水混合制备而成。本发明的有益效果是：既具有清除口腔异味、细菌，缓解口腔溃疡、咽喉肿痛、牙龈出血和肿痛等功效，还可避免市售常规口腔护理液中冰片、香精等化学成分对孕妇造成的流产、对婴幼儿造成智力发育障碍及对体质虚弱人群造成的过敏性刺激等伤害。
Description
所属技术领域
本发明涉及一种口腔护理液，尤其涉及一种纯中药口腔护理液，此口腔护理液不添加任何人工合成化学成分，具有良好的清新口气、清洁口腔、牙齿，清除口腔异味，缓解口腔溃疡、咽喉肿痛、牙龈出血和肿痛等功效。
背景技术
据调查，我国年龄在35-44周岁的中年人群中龋齿率高达88.10%；而妊娠期妇更是口腔疾病的高发人群，调查发现孕妇牙结石检出率为90.01%，牙软垢检出率更高达98.00%，且随着孕周的增加孕妇口腔卫生日益恶化，而这些问题将直接影响孕妇及婴幼儿的身体健康。毫不夸张的说，几乎每个中国人都着受过口腔疾病的困扰，口腔健康令人担忧。
目前，虽然市场上出售着各种护理口腔、牙齿，清除口腔异物、细菌和缓解口腔溃疡的漱口水及口腔护理液，然而此类口腔护理液中大部分都含有冰片、香精、甲硝唑、双氧水、水杨酸甲酯、氟化物及一些抗菌剂、甜味剂等一些化学类成分，长期使用含这些化学成分的口腔护理液会对人口腔黏膜产生一定的刺激性，不利于口腔健康；且冰片、麝香等成分易造成孕妇流产、对婴儿产生不良影响，所以不能被孕妇所接受。虽部分中药口腔护理液不含上述化学成分，但要么其组成、制备过程复杂，要么其口感较差不为大多数消费者所接受。
金银花性寒、味甘，归肺、心、胃经，是我国中医临床常用的传统中药材，其主要有效成份是有机酸类、黄酮类、三萜皂苷类和挥发油类，具有清热解毒、凉风散热、抗菌、抗炎解热等药理作用，临床上主要用于外感风热、温病初起、红肿热痛、疮疡病毒和便脓血等，外用具有治疗痈肿疮疡的功效。目前，金银花在药物制剂、饮料、食品和和化妆品等方面都有很多已开发产品，如维C银翘片、双黄连口服液、金银花漱口水、金银花绿茶、金银花润喉茶、金银花牙膏和金银花洗浴剂等。
地椒性平，味辛，又称地花椒、百里香、山椒和山胡椒，为唇形科植物百里香的全草，具有祛风止咳、健脾行气、利湿通淋等功效。《中国药植图鉴》中记载其具有镇痉、祛风等作用，主治炎症、喉头肿痛、痉挛性咳嗽。《陕西中草药》记载地椒具有温中散寒、祛风镇痛的功效，主治寒痛、周身疼痛、牙痛、疮痈肿痛、消化不良等症。《海上名方》中记载“地花椒、川芎藭尖等分，为末，擦之”可治牙痛。
罗勒性温，味辛、甘，又名九层塔、零陵香、香草、香佩兰等，为唇形科植物罗勒的地上部分，气香味纯，可作为牙膏、漱口水的矫味剂。有解毒消肿、疏风解表之功效，主治感冒头疼、牙痛口臭、皮肤湿疹等症。（《中华本草》）；《嘉祐本草》中记载罗勒可“调中消食，去恶臭，消水气，宜生食。又疗齿根烂疮，为灰用甚良。”《山东中草药手册》香佩兰15g，金银花15g，细辛3g，水煎服；《天津中草药》零陵香，水煎，含漱；此二方均可治牙龈肿痛。
野菊花性凉，味苦、甘，归肺肝经。具有清热解毒，疏风平肝之功效。主治疔疮、痈疽、丹毒、湿疹、皮炎、咽喉肿痛、风热感冒。1982版《四川中药志》记载野菊花具有疏风、散热、解毒之功效，用于感冒、疮痈肿毒、咽喉肿痛及风火赤眼等症；野菊花15g、夏枯草15g、千里光15g、桑叶9g和甘草3g，水煎服，可治风热目赤肿痛等症。《岭南草药志》记载野菊花和黄糖捣烂贴患处，可治疔疮。
发明内容
为了克服已有口腔护理液使用的局限性，本发明提供一种纯中药口腔护理液及其制备工艺，该口腔护理液不仅能适应大多数普通体质人群对清洁口腔的需求，而且还能克服其使用局限，满足孕妇及大多数易过敏人群对口腔护理液的需求且不至对其造成流产或过敏伤害。
本发明屏弃传统上制备口腔护理液的技术方案，采用全新的、纯绿色的制备方法。此口腔护理液不添加任何人工合成辅料、防腐剂等化学成分，仅将一定份数的金银花、地椒、罗勒、野菊花的提取物和一定份数的纯净水混合制备而成。
本发明解决该技术问题的具体技术方案是：
一种纯中药口腔护理液，其特征在于，包括以下份数的组分混合而成：金银花提取物2-4份，地椒提取物2-4份，罗勒提取物1-2份，野菊花提取物1-2份，纯净水88-94份。
所述金银花提取物为取干燥金银花花蕾，粉碎，过20目筛，加入18-22倍量的蒸馏水，于90-95℃条件下加热提取75-90min，过滤，滤渣加入8-12倍量的蒸馏水，再于90-95℃条件下加热提取55-65min，过滤，合并上述提取液，减压浓缩成浸膏后于真空条件下冷冻干燥得金银花浸提物。
所述地椒提取物为取开花期地椒地上部分，除去泥土杂质，干燥粉碎，过40目筛，加入14-16倍量的蒸馏水，于90-95℃条件下加热提取90-100min，过滤，滤渣加入8-12倍量的蒸馏水于上述温度下加热提取55-65min，过滤，合并上述提取液，减压浓缩成浸膏后于真空条件下冷冻干燥得地椒浸提物。
所述罗勒提取物为取开花期罗勒地上部分，除去泥土杂质，干燥粉碎，过40目筛，加入14-16倍量的蒸馏水于85-90℃条件下加热提取60-70min，过滤，滤渣加入8-12倍量的蒸馏水，于上述温度下加热提取55-65min，过滤，合并上述滤液，减压浓缩成浸膏后于真空条件下冷冻干燥得罗勒浸提物。
所述野菊花提取物为取干燥野菊花，粉碎，过20目筛，加入18-22倍量的蒸馏水，于90-95℃条件下加热提取75-90min，过滤，滤渣加入8-12倍的蒸馏水，于上述温度下加热提取55-65min，过滤，合并上述滤液，减压浓缩成浸膏后于真空条件下冷冻干燥得野菊花浸提物。
进一步地，所述金银花提取物为取干燥金银花花蕾，粉碎，过20目筛，加入18倍量的蒸馏水，于95℃条件下加热提取90min，过滤，滤渣加入12倍量的蒸馏水，再于90-95℃条件下加热提取60min，过滤，合并上述提取液，减压浓缩成浸膏后于真空条件下冷冻干燥得金银花浸提物。
所述地椒提取物为取开花期地椒地上部分，除去泥土杂质，干燥粉碎，过40目筛，加入15倍量的蒸馏水，于95℃条件下加热提取90min，过滤，滤渣加入10倍量的蒸馏水于上述温度下加热提取60min，过滤，合并上述提取液，减压浓缩成浸膏后于真空条件下冷冻干燥得地椒浸提物。
所述罗勒提取物为取开花期罗勒地上部分，除去泥土杂质，干燥粉碎，过40目筛，加入15倍量的蒸馏水于90℃条件下加热提取65min，过滤，滤渣加入10倍量的蒸馏水，于上述温度下加热提取55min，过滤，合并上述滤液，减压浓缩成浸膏后于真空条件下冷冻干燥得罗勒浸提物。
所述野菊花提取物为取干燥野菊花，粉碎，过20目筛，加入20倍量的蒸馏水，于95℃条件下加热提取90min，过滤，滤渣加入10倍的蒸馏水，于上述温度下加热提取60min，过滤，合并上述滤液，减压浓缩成浸膏后于真空条件下冷冻干燥得野菊花浸提物。
进一步地，所述纯中药口腔护理液包括以下份数的组分混合而成：金银花提取物4份，地椒提取物4份，罗勒提取物2份，野菊花提取物2份，纯净水88份。
所述口腔护理包括下以下功效的全部或部分：清新口气，清洁口腔、牙齿，清除口腔异味、细菌，缓解口腔溃疡、咽喉肿痛、牙龈出血和肿痛。
上述工艺中，4种有效成分金银花提取物、地椒提取物、罗勒提取物和野菊花提取物在制得后分别储存或混合后储存，使用时或使用前将上述有效成分与纯净水按比例充分混匀。
本发明的有益效果是：本发明属一种纯中药口腔护理液，本发明不含有对人体有害的冰片、香精、甲硝唑、双氧水、水杨酸甲酯、氟化物及一些抗菌剂、甜味剂等一些化学类成分，且具有清新口气，清洁口腔、牙齿，清除口腔异味、细菌，缓解口腔溃疡、咽喉肿痛、牙龈出血和肿痛等功效，可避免市售常规口腔护理液中冰片、香精等化学成分对孕妇造成的流产、对婴幼儿造成智力发育障碍及对体质虚弱人群造成的过敏性刺激等伤害。且本发明相对于其他中药口腔护理液具有效果更佳、生产方法简单、生产成本低廉，具有更广阔的开发前景。
且此纯中药口腔护理液相对于其他中药口腔护理液具有效果更佳、生产方法简单、生产成本低廉，具有更广阔的开发前景。
本发明的附加方面和优点将在下面的描述中部分给出，部分将从下面的描述中变得明显，或通过本发明的实践了解到。
具体实施方式
以下结合具体实例，对本发明进行详细说明。
实施例1
本发明提供的为一种纯植物提取的口腔护理液，其为一种淡黄色澄清透明且有一定淡清香气味的口腔护理液，该护理液具有清新口气，清洁口腔、牙齿，清除口腔异味、细菌，缓解口腔溃疡、咽喉肿痛、牙龈出血和肿痛等功效。本发明由取金银花浸提物4份，地椒浸提物4份，罗勒浸提物2份，野菊花浸提物2份，纯净水88份充分混匀即得纯中药口腔护理液。
本发明的具体制作工艺为：
优选的，所述金银花浸提物为取干燥金银花花蕾100 g，粉碎，过20目筛，加入1.8 L蒸馏水，于95℃条件下加热提取90min，过滤，滤渣加入1.2 L蒸馏水，再于上述条件下加热提取60min，过滤，合并上述提取液，减压浓缩成浸膏后于真空条件下冷冻干燥得金银花浸提物。
优选的，所述地椒浸提物为取开花期地椒地上部分，除去泥土杂质，干燥粉碎，过40目筛，准确称取100 g，加入1.5 L蒸馏水，于95℃条件下加热提取90min，过滤，滤渣加入1.0 L蒸馏水于上述温度下加热提取60min，过滤，合并上述提取液，减压浓缩成浸膏后于真空条件下冷冻干燥得地椒浸提物。
优选的，所述罗勒浸提物为取开花期罗勒地上部分，除去泥土杂质，干燥粉碎，过40目筛，准确称取100 g，加入1.5 L蒸馏水于90℃条件下即热回流提取65min，过滤，滤渣加入1.0 L蒸馏水，于上述温度下加热提取55min，过滤，合并上述滤液，减压浓缩成浸膏后于真空条件下冷冻干燥得罗勒浸提物。
优选的，所述野菊花浸提物为取干燥野菊花100 g，粉碎，过20目筛，加入2.0 L蒸馏水，于95℃条件下加热提取90min，过滤，滤渣加入1.0 L馏水，于上述温度下加热提取60min，过滤，合并上述滤液，减压浓缩成浸膏后于真空条件下冷冻干燥得野菊花浸提物。
本发明是一种纯中药口腔护理液，不添加可能对人体产生伤害的冰片、香精、甲硝唑、双氧水、水杨酸甲酯、氟化物及一些抗菌剂、甜味剂等一类化学成分，降低了对常规口腔护理液过敏的人群概率。且此口腔护理液不含孕妇禁用的人工香精和冰片，保障了使用口腔护理液孕妇的人身安全。为了进一步检验本专利的有效性及安全性，实验人员在山东长清大学城及周边的居民小区选取了198名有口腔疾病的志愿者，其中有口腔溃疡者52名、牙周病者57名、咽喉肿痛者46名和有口腔异味者43名，进行了为期7天的跟踪调查治疗。包括孕妇6人和有过敏史者3人。年龄最小者18周岁，最大者77周岁。
本发明的具体使用方法为：上述有口腔问题的志愿者每次饭后与睡前使用本发明，每次约20mL，漱口后唅30-60S，每日四次。
对上述志愿者治疗情况进行统计：有口腔溃疡者52名中38名使用本专利第3天开始出现好转，7天后52名患者中47名痊愈，另外5名患者溃疡明显好转，溃烂面明显减小，疼痛感减轻，其有效率为100%，治愈率为90%。57名有牙周病患者使用本专利7天后，其中53名患者牙龈红肿、疼痛、出血及溢脓症状明显改善，有效率为93%，另外4患者以上症状改善不显著。有咽喉肿痛者46名中39名患者使用过本专利后第3天疼痛、炎症等症开始好转，七天后45名患者全部治愈，其治愈率为98%。43名有口腔异味者使用本专利7天后，其中29名患者口腔异味症状明显改善，8名患者上述症状有所好转，而另外6名患者反映本专利无效，其有效率为86%。在所有使用本专利的志愿者中没有出现任何感觉不适或其他过敏反应情况。
实施例2
为了进一步检验本专利的有效性及安全性，实验人员选取一种市售含有洗必泰和甲硝唑的口腔护理液作为对照组。实验人员在山东长清大学城及周边的居民小区选取了138名有口腔疾病的志愿者，其中有口腔溃疡者32名、牙周病者40名、咽喉肿痛者35名和有口腔异味者31名，进行了为期7天的跟踪调查治疗。138名志愿者中年龄最小者21周岁，最大者73周岁，所有志愿者对甲硝唑和乙醇均无过敏史。
对照组市售含洗必泰和甲硝唑口腔护理液的具体使用方法参考使用说明书：每天2-3次，每次约15 mL，含漱约30 S。
对志愿者治疗情况进行统计：有口腔溃疡者32名中11名使用对照品口腔护理液第3天开始出现好转，7天后32名患者中27名痊愈，有3名患者溃疡明显好转，溃烂面明显减小，疼痛感减轻，另外2名患者反应对照品无效，其有效率为94%，治愈率为84%。40名有牙周病患者使用对照品口腔护理液7天后，其中36名患者牙龈红肿、疼痛、出血及溢脓症状明显改善，有效率为90%，另外4患者以上症状改善不显著。有咽喉肿痛者35名中26名患者使用过对照品口腔护理液后第3天疼痛、炎症等症开始好转，七天后32名患者全部治愈或有不同程度好转，另外3名患者反应对照品无效，且有1名患者反应疼痛加剧的趋势，其治愈率为91%。31名有口腔异味者使用对照品口腔护理液7天后，其中22名患者口腔异味症状明显改善，2名患者上述症状有所好转，有6名患者反映无效，另有1名患者反应使用过对照品口腔护理液后出现口臭加剧、口干和口腔金属味等不适反应，其有效率为77%。但在138名志愿者中有1名患者使用过对照品口腔护理液后出现了恶心、厌食、呕吐的副反应，有1名咽喉肿痛患者出现了咽喉疼痛加剧的现象，另有1名患者出现口臭加剧、口干和口腔金属味等不适反应，上述3名志愿者在停止使用对照品口腔护理液1-2天后上述症状自行消失。
Claims (6)
1.一种纯中药口腔护理液，其特征在于，包括以下份数的组分混合而成：金银花提取物2-4份，地椒提取物2-4份，罗勒提取物1-2份，野菊花提取物1-2份，纯净水88-94份。
2.根据权利要求1所述的纯中药口腔护理液，其特征在于，所述金银花提取物为取干燥金银花花蕾，粉碎，过20目筛，加入18-22倍量的蒸馏水，于90-95℃条件下加热提取75-90min，过滤，滤渣加入8-12倍量的蒸馏水，再于90-95℃条件下加热提取55-65min，过滤，合并上述提取液，减压浓缩成浸膏后于真空条件下冷冻干燥得金银花浸提物。
3.根据权利要求1所述的纯中药口腔护理液，其特征在于，所述地椒提取物为取开花期地椒地上部分，除去泥土杂质，干燥粉碎，过40目筛，加入14-16倍量的蒸馏水，于90-95℃条件下加热提取90-100min，过滤，滤渣加入8-12倍量的蒸馏水于上述温度下加热提取55-65min，过滤，合并上述提取液，减压浓缩成浸膏后于真空条件下冷冻干燥得地椒浸提物。
4.根据权利要求1所述的纯中药口腔护理液，其特征在于，所述罗勒提取物为取开花期罗勒地上部分，除去泥土杂质，干燥粉碎，过40目筛，加入14-16倍量的蒸馏水于85-90℃条件下加热提取60-70min，过滤，滤渣加入8-12倍量的蒸馏水，于上述温度下加热提取55-65min，过滤，合并上述滤液，减压浓缩成浸膏后于真空条件下冷冻干燥得罗勒浸提物。
5.根据权利要求1所述的纯中药口腔护理液，其特征在于，所述野菊花提取物为取干燥野菊花，粉碎，过20目筛，加入18-22倍量的蒸馏水，于90-95℃条件下加热提取75-90min，过滤，滤渣加入8-12倍的蒸馏水，于上述温度下加热提取55-65min，过滤，合并上述滤液，减压浓缩成浸膏后于真空条件下冷冻干燥得野菊花浸提物。
6.权利要求1-5任一项所述的一种纯中药口腔护理液的制备工艺，其特征在于，取所述组份混合制备而成。
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