CN111821414A - Traditional Chinese medicine itching relieving spray and preparation method thereof - Google Patents

Traditional Chinese medicine itching relieving spray and preparation method thereof Download PDF

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CN111821414A
CN111821414A CN202010711590.4A CN202010711590A CN111821414A CN 111821414 A CN111821414 A CN 111821414A CN 202010711590 A CN202010711590 A CN 202010711590A CN 111821414 A CN111821414 A CN 111821414A
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traditional chinese
chinese medicine
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itching relieving
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张春杰
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Jiaozuo Secco Traditional Chinese Medicine Biotechnology Co ltd
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Jiaozuo Secco Traditional Chinese Medicine Biotechnology Co ltd
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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Abstract

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine itching relieving spray and a preparation method thereof. The traditional Chinese medicine itching relieving spray takes rhizoma atractylodis, mint, asarum, radix angelicae, cortex mori radicis, rhizoma zingiberis, clove, macleaya cordata, eupatorium, folium mori, bunge pricklyash peel, cacumen biotae and shikimic as main medicinal components. Effective components are extracted by respectively adopting alcohol soaking and vinegar soaking, so that the drug effect is enhanced; the substrate contains 75% alcohol, and after spraying, the substrate can promote skin to absorb effective components, quickly relieve symptoms and accelerate cell tissue regeneration; the white vinegar containing various organic acids can accelerate cutin renewal, help skin melanin to peel off, narrow pores and promote damaged skin repair; reduce the stimulation of hormone drugs to the skin, and has remarkable effect.

Description

Traditional Chinese medicine itching relieving spray and preparation method thereof
Technical Field
The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine itching relieving spray and a preparation method thereof.
Background
Pruritus is a cutaneous sensation that can cause the urge to scratch, and is also a common symptom of localized pruritus and neurodermatitis. The effective components of the traditional antipruritic are capsaicin, anesthetic, calcineurin inhibitor, glucocorticoid, cannabinoids, doxepin, prostate inhibitor, etc.
Capsaicin acts on TRPV1 to consume substance P to relieve itching, and can be used for treating localized itching, especially neurogenic itching such as paresthesia back pain, brachioradialis pruritus and postherpetic neuralgia, and prurigo nodularis, watery pruritus, psoriasis and uremia pruritus.
Topical local anesthetic such as 1% pramoxine cream, 2.5-5% lidocaine and 2.5% prilocaine compound cream can be used for treating neurogenic pruritus and pruritus of face or genito-anal region. The main adverse reaction is local numbness and occasionally skin allergy.
Topical calcineurin inhibitors including tacrolimus and pimecrolimus may produce an indirect antipruritic effect by modulating T cell activation and inhibiting inflammatory cytokine release, and may also produce a direct antipruritic effect via TRPV 1. Calcineurin inhibitors can relieve the itching symptoms of inflammatory dermatoses such as eczema, anogenital pruritus, lichen sclerosis, lichen planus and prurigo nodularis. The calcineurin inhibitor does not cause skin atrophy and can be applied to the skin of the face, genitals and intergenital areas. The common side effect is a transient burning sensation which occurs within days after the start of medication, is probably caused by TRPV1 activation and is usually relieved after repeated medication for days, and the burning sensation is considered to be a biological marker for the onset of the antipruritic effect.
Clinically, glucocorticoid is usually externally used for treating pruritus, actually, the hormone itself has no direct antipruritic effect, indirectly controls pruritus by inhibiting the action of cytokines and relieving local inflammation, and is also effective on secondary manifestations of chronic pruritus such as nodular inflammation and chronic simple moss. The side effects of topical glucocorticoids include local atrophy, pigment changes, telangiectasia, systemic absorption risks, etc. and should be avoided over large areas for long-term use. In addition, hormones may also exhibit tachyphylaxis, i.e., a decrease in efficacy after multiple external administrations.
Some studies have demonstrated the efficacy of cannabinoids in relieving itching. In an open trial conducted in 3000 atopic dermatitis patients, the N-palmitoylethanolamide cream significantly reduced itching and disease severity. In addition, cannabinoids are effective against chronic simple lichen, prurigo nodularis and uremic pruritus with minimal side effects.
Doxepin is a tricyclic antidepressant with anti-H effect1And anti-H2The external preparation is 5% cream, and can be used for short-term treatment of atopic dermatitis, lichen simplex chronicus, nummular eczema and contact dermatitis. Can be absorbed systemically to cause lethargy and allergic contact dermatitis, so it should be avoided to be used in large area (less than 5% of body surface area) and for long time (less than 7 days), and should be forbidden for children, pregnant women and lactating women, and should be used with cautions for the elderly.
Prostaglandin inhibitors, aspirin and salicylate exert an antipruritic effect by inhibiting the itch-enhancing factor prostaglandin E2, and can be used for chronic lichen simplex, with a common side effect of transient burning sensation.
The medicinal components have slow effect, are not suitable for long-term use, are easy to cause drug resistance of organisms, and are easy to relapse after the medicine is stopped for some patients with serious eczema, psoriasis and dermatitis. Therefore, the technical problem to be solved in the field is to provide a pure traditional Chinese medicine itching relieving spray which can quickly relieve itching, thoroughly prevent and treat eczema, psoriasis and dermatitis, repair damaged skin, prevent insects and sterilize.
Disclosure of Invention
Aiming at the defects and problems of slow effect taking, easy repetition and unsuitability for long-term use of the existing antipruritic medicines, the invention provides a traditional Chinese medicine antipruritic spray and a preparation method thereof.
The technical scheme adopted by the invention for solving the technical problems is as follows: a traditional Chinese medicine itching relieving spray comprises the following traditional Chinese medicine raw materials in parts by weight: 20-30 parts of rhizoma atractylodis, 20-30 parts of mint, 5-10 parts of asarum, 10-20 parts of radix angelicae, 10-20 parts of cortex mori radicis, 5-10 parts of rhizoma zingiberis, 10-20 parts of clove, 5-10 parts of macleaya cordata, 10-20 parts of eupatorium, 10-20 parts of folium mori, 5-10 parts of hollyhock, 10-20 parts of cacumen biotae and 5-10 parts of shikimic.
The traditional Chinese medicine itching relieving spray comprises the following traditional Chinese medicine raw materials in parts by weight: 25 parts of rhizoma atractylodis, 25 parts of mint, 8 parts of asarum, 15 parts of angelica dahurica, 15 parts of white mulberry root-bark, 8 parts of rhizoma zingiberis, 15 parts of clove, 8 parts of macleaya cordata, 15 parts of eupatorium fortunei, 15 parts of mulberry leaf, 8 parts of pepper, 15 parts of cacumen biotae and 8 parts of shikimic acid.
The traditional Chinese medicine itching relieving spray also comprises 1500 parts of 75% ethanol solution 1200-.
The invention also provides a preparation method of the traditional Chinese medicine itching relieving spray, which comprises the following steps:
(1) pulverizing rhizoma Atractylodis, herba Menthae, radix Angelicae Dahuricae, flos Caryophylli, herba Eupatorii, herba asari, Zingiberis rhizoma, folium Mori, cortex Mori, cacumen Platycladi, herba Macleayae Cordatae, fructus Zanthoxyli, and folium Illicii Lanceolati to 40-60 mesh respectively.
(2) Weighing rhizoma Atractylodis, herba Menthae, radix Angelicae Dahuricae, flos Caryophylli, herba Eupatorii, herba asari and Zingiberis rhizoma according to a certain proportion, mixing well to obtain medicinal powder I, adding 75% ethanol solution 8-10 times of the weight of medicinal powder I, soaking for 48-72h, stirring for 3-5 times regularly, filtering after soaking, and collecting alcohol filtrate;
(3) vacuum concentrating the alcohol filtrate until the weight of the concentrated solution is 0.8-1.2 times of that of the medicinal powder I, and collecting distilled ethanol for later use; placing the concentrated solution in a high-speed centrifuge, centrifuging at low temperature of 7500-.
(4) Weighing folium Mori, cortex Mori, folium Platycladi, herba Macleayae Cordatae, fructus Zanthoxyli and folium Illicii Lanceolati according to a certain proportion, mixing well to obtain medicinal powder II, adding 3.5 degree vinegar 3-6 times the weight of medicinal powder II, soaking for 48-72h, stirring for 3-5 times regularly, filtering after soaking, and collecting vinegar filtrate.
(5) Vacuum concentrating the vinegar filtrate until the weight of the concentrated solution is 0.8-1.2 times of the weight of the medicinal powder II, and collecting vinegar distillate; placing the concentrated solution in a high-speed centrifuge, centrifuging at low temperature of 7500-.
(6) Adding 1% -2% of menthol and 1-1.5% of borneol into the distilled ethanol to prepare an alcoholic solution of the menthol and the borneol as a solution III.
(7) And combining the solution I and the solution II to obtain a mixed liquid medicine, and diluting the mixed liquid medicine and the solution III according to the ratio of 1:4-5 to obtain the itching relieving spray stock solution.
(8) And (3) uniformly mixing the itching relieving spray stock solution, the vinegar distillate obtained in the step (5) and glycerol according to the volume ratio of 3:1:1 to obtain a mixed solution, and adding 0.1-0.2 per mill of rose essential oil into the mixed solution to obtain the finished product of the traditional Chinese medicine itching relieving spray.
In the preparation method of the traditional Chinese medicine itching relieving spray, the soaking time in the step (2) and the soaking time in the step (4) are both 72 hours.
In the preparation method of the traditional Chinese medicine itching relieving spray, the vinegar filtrate is concentrated in vacuum in the step (3) until the weight of the concentrated solution is the same as that of the medicinal powder I.
In the preparation method of the traditional Chinese medicine itching relieving spray, the vinegar filtrate is concentrated in vacuum in the step (5) until the weight of the concentrated solution is the same as that of the medicinal powder II.
The method comprises the following steps: the rhizoma atractylodis contains atractylone, 2-carene, atractylenolide, patchouli, elemene, acetyl xanthinol, dehydroxylin ester and other ingredients, has the effects of eliminating dampness, strengthening spleen, dispelling wind and removing cold, belongs to a dampness-resolving medicine, and has obvious effects on dermatophytosis and rheumatic arthralgia.
The mint has the effects of dispersing light weight, dispelling wind and heat, dispersing toxin, promoting eruption, dispelling wind and arresting itching, and has obvious effects on measles without adequate eruption and rubella pruritus.
Radix Angelicae Dahuricae has effects of relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, dredging nasal orifice, eliminating dampness, relieving leukorrhagia, relieving swelling, expelling pus, dispelling pathogenic wind and relieving itching, and can be used for treating skin ulcer, carbuncle, pyogenic infections, skin rheumatism, pruritus, contact dermatitis, eczema, carbuncle and furuncle.
Flos Caryophylli and herba Eupatorii have effects of clearing away heat, promoting diuresis, and eliminating turbid pathogen with aromatics; especially for mosquito bites in summer, the itching caused by mosquito bites can be immediately stopped by rubbing the water out and applying the water to the bitten parts. It also has significant effect on skin toxic heat and injury caused by eczema, psoriasis and dermatitis.
The functions of the asarum and the dried ginger are overlapped, such as pungent-warm nature, dispelling wind and relieving itching, and the medicine is effective on various skin diseases, especially pruritus caused by wind evil; can also be used for treating diseases such as damp-heat, blood deficiency and wind dryness. The radix angelicae and the asarum are used in combination, the radix angelicae and the asarum are both pungent, warm and fragrant, and can expel wind, relieve exterior syndrome, dispel cold, relieve pain and dredge nasal orifices.
The mulberry leaf and the white mulberry root-bark can disperse wind, clear heat and remove toxicity, and have obvious effect on sore and carbuncle swelling.
Ce Bai Ye astringes to cool blood to stop bleeding, can relieve heat bleeding caused by itching scratching, and remove toxicity, so it is the essential herb for treating burn, sores and ulcers.
Macleaya cordata is bitter and pungent in taste, cold and warm in nature, and mainly treats pain, sore, furuncle, ecthyma, hemorrhoids, eczema and snake and insect bites.
The pricklyash peel has a special effect on itching of the dermatitis rhus; shikim has the functions of dispelling wind and relieving swelling, and is mainly used for treating head wind, carbuncle swelling, skin paralysis, scrofula, acute mastitis, pharyngitis, hernia, tinea, scabies, tinea, sore, and the like.
The matrix is 75% alcohol, has good transdermal effect after spraying, can promote skin absorption, rapidly relieve symptoms, and accelerate tissue cell regeneration. The vinegar is rich in various organic acids such as acetic acid, citric acid, malic acid, succinic acid and the like, has the main effects of accelerating cutin renewal, helping the stripping of melanin in skin, shrinking pores, dissolving blackheads, repairing damaged skin and the like, and can make the skin soft and comfortable, and make the skin color fresh and pure.
The spray also contains appropriate amount of Mentholum and Borneolum Syntheticum, has fragrant smell, pungent and cool taste, has antibacterial and antiinflammatory, resuscitation inducing, heat clearing away, analgesic, heat clearing away, pathogenic fire purging, toxic materials clearing away, repercussive, dampness eliminating, sore healing, and antipruritic effects. In addition, the faint scent and coolness of the borneol also increase the comfort of the patient during spraying. The rose essential oil can improve the smell of the traditional Chinese medicine of the spray, can also improve the dryness of the skin, recover the elasticity of the skin and repair the damaged skin.
The invention has the beneficial effects that:
1. the traditional Chinese medicine itching relieving spray integrates the drug effects of the raw materials, and realizes the synergy and the superposition of the effects of different raw materials on different skin pruritus diseases according to the compatibility principle.
2. The finished product is clear and bright, and can be sprayed on skin to quickly produce cool and comfortable feeling.
3. The solvent is 75% medical alcohol, which has sterilization and disinfection effects, and has no coloring and no pollution to clothes.
4. The itching relieving spray has the advantages that the medicinal materials and the matrix used in the itching relieving spray have the effect of treating skin diseases, the traditional Chinese medicine accounts for 100%, the content of the effective components of rhizoma atractylodis, radix angelicae dahuricae and mint reaches 15% -20%, the medicine release and transdermal property are strong, the curative effect is improved, and the treatment course is shortened by 1/2-3/4 compared with that of the common itching relieving spray.
5. The product is convenient for use and carrying, and the medicine can rapidly contact with skin to exert effect.
6. Reduces the irritation and allergic reaction to the skin, and is particularly suitable for patients with hormone drugs with allergic history.
7. Because the spray is a pure traditional Chinese medicine external preparation, the dosage does not need to be strictly controlled, and the phenomena of drug resistance and double infection caused by the fact that the antibiotic external medicine and the Chinese and western composite external medicine need to be strictly applied according to the dosage are avoided.
8. The traditional Chinese medicine itching relieving spray has wide anti-inflammatory and antibacterial effects, and has remarkable effects on skin diseases such as acne, allergic dermatitis, various tinea maculae and the like; also has good effect on skin burn, snake and insect bite, red swelling and pain caused by wound, etc., and can accelerate skin regeneration.
9. The preparation method adopts the methods of low-temperature cold taking, low-temperature centrifugation, microporous membrane filtration and back dilution to obtain the traditional Chinese medicine itching relieving spray which has relatively small molecular weight and is very easy to be absorbed and utilized by skin, thereby not only reducing the resistance during spraying, but also rapidly atomizing the liquid medicine, increasing the contact area with the skin, increasing the transdermal effect of other traditional Chinese medicine functional components due to volatile components in the menthol and the borneol, and ensuring the functional effect of the traditional Chinese medicine itching relieving spray; the product has simple preparation process, and the rose essential oil has effects of refreshing brain, masking traditional Chinese medicine smell, and does not need excessive manpower and material resources, and is suitable for batch production.
Drawings
FIG. 1 is a graph comparing before and after the spray of the present invention was used in case 1.
Fig. 2 is a graph comparing before and after the spray of the present invention was used in case 2.
Fig. 3 is a graph comparing before and after the spray of the present invention was used in case 3.
Fig. 4 is a graph comparing before and after the spray of the present invention was used in case 4.
Detailed Description
The present invention will be further described with reference to the following examples.
Example 1: the embodiment provides a traditional Chinese medicine itching relieving spray which is prepared from the following traditional Chinese medicine raw materials of 25 parts of rhizoma atractylodis, 25 parts of mint, 8 parts of asarum, 15 parts of angelica dahurica, 15 parts of cortex mori radicis, 8 parts of rhizoma zingiberis, 15 parts of clove, 8 parts of macleaya cordata, 15 parts of eupatorium, 15 parts of folium mori, 8 parts of pepper, 15 parts of cacumen biotae and 8 parts of shikimic.
The preparation process comprises the following steps: pulverizing rhizoma Atractylodis, herba Menthae, radix Angelicae Dahuricae, flos Caryophylli, herba Eupatorii, herba asari, Zingiberis rhizoma, folium Mori, cortex Mori, cacumen Platycladi, herba Macleayae Cordatae, fructus Zanthoxyli, and folium Illicii Lanceolati to 50 mesh respectively; if the crushing granularity is too fine, the medicinal powder is easily wrapped into a mass by a solvent during extraction, so that the effective ingredients are not easy to dissolve out, and if the crushing granularity is too coarse, the contact area of the medicinal material and the extracting agent is smaller, so that the effective ingredients are not easy to dissolve out to the maximum extent.
Weighing rhizoma atractylodis, mint, angelica dahurica, clove, eupatorium fortunei, asarum and dried ginger powder according to a ratio, uniformly mixing to obtain medicinal powder I, placing the medicinal powder I in a glass container, adding 75% ethanol solution which is 10 times of the weight of the medicinal powder, soaking for 72 hours to ensure that the ethanol liquid level is over the medicinal material, uniformly stirring to ensure that the medicinal material is fully contacted with a solvent, sealing and standing to prevent alcohol from volatilizing. Tests show that the dipping time is too short, the effective components can not be fully dissolved, the dipping time reaches about 72 hours, and the dissolution rate of the effective components is basically not changed; stirring for 3-5 times, filtering after soaking, and collecting alcohol filtrate. Soaking rhizoma Atractylodis, herba Menthae, radix Angelicae Dahuricae, flos Caryophylli, herba Eupatorii, herba asari and Zingiberis rhizoma in 75% ethanol to extract atractylodin in rhizoma Atractylodis, imperatorin in radix Angelicae Dahuricae, eugenol in flos Caryophylli and aromatic volatile oil in herba Menthae, herba Eupatorii and Zingiberis rhizoma.
Vacuum concentrating the alcohol filtrate until the weight of the concentrated solution is the same as that of the medicinal powder I, and collecting the distilled ethanol for later use. Centrifuging the concentrated solution in a high speed centrifuge at 8000r/min for 12min, removing precipitate, collecting supernatant, filtering with 0.45 μm organic microporous membrane, removing macromolecular substances, and collecting filtrate as solution I.
Weighing folium Mori, cortex Mori, cacumen Platycladi, herba Macleayae Cordatae, fructus Zanthoxyli and folium Illicii powder according to a certain proportion, mixing well to obtain medicinal powder II, adding 3.5 degree white vinegar 5 times of the medicinal powder II, soaking for 72h, stirring for 3-5 times, filtering after soaking, and collecting vinegar filtrate. The mulberry leaf, the white mulberry root-bark, the Chinese arborvitae twig, the macleaya cordata, the pricklyash peel and the shikimic acid are extracted by the white acetic acid, which is beneficial to extracting flavone, polyphenol and alkaloid substances in medicinal materials and has synergistic effect.
Vacuum concentrating the vinegar filtrate until the weight of the concentrated solution is equal to that of the medicinal powder II, and collecting vinegar distillate; centrifuging the concentrated solution in a high speed centrifuge at 8000r/min for 12min, removing precipitate, collecting supernatant, filtering with 0.45 μm water system microporous membrane to remove macromolecular substances, and collecting filtrate as solution II.
Adding 1.5% menthol and 1.2 ‰ Borneolum Syntheticum into distilled ethanol to obtain menthol and Borneolum alcoholic solution as solution III.
And combining the solution I and the solution II to obtain a mixed liquid medicine, and performing back dilution on the mixed liquid medicine and the solution III according to the ratio of 1:4.5 to obtain an itching relieving spray stock solution, namely diluting the mixed liquid medicine and the solution III by 4.5 times of the solution III based on the total weight of the solution I and the solution II.
Uniformly mixing the itching relieving spray stock solution and the vinegar distillate according to the volume ratio of 3:1:1 to obtain a mixed solution, and adding 0.15 per mill of rose essential oil into the mixed solution to obtain the finished product of the traditional Chinese medicine itching relieving spray.
Example 2: the embodiment provides a traditional Chinese medicine itching relieving spray which is prepared from the following traditional Chinese medicine raw materials of 20 parts of rhizoma atractylodis, 30 parts of mint, 5 parts of asarum, 20 parts of angelica dahurica, 20 parts of cortex mori radicis, 10 parts of rhizoma zingiberis, 10 parts of clove, 10 parts of macleaya cordata, 20 parts of eupatorium, 20 parts of folium mori, 10 parts of hollyhock, 10 parts of cacumen biotae and 5 parts of shikimic.
The preparation process comprises the following steps: pulverizing rhizoma Atractylodis, herba Menthae, radix Angelicae Dahuricae, flos Caryophylli, herba Eupatorii, herba asari, Zingiberis rhizoma, folium Mori, cortex Mori, folium Platycladi, herba Macleayae Cordatae, fructus Zanthoxyli, and folium Illicii Lanceolati to 40 mesh respectively.
Weighing rhizoma Atractylodis, herba Menthae, radix Angelicae Dahuricae, flos Caryophylli, herba Eupatorii, herba asari and Zingiberis rhizoma powder according to a certain ratio, mixing well to obtain medicinal powder I, placing into a glass container, adding 75% ethanol solution 8 times the weight of medicinal powder, soaking for 64h, stirring for 3-5 times, filtering after soaking, and collecting alcohol filtrate.
Vacuum concentrating the alcohol filtrate until the weight of the concentrated solution is 1.2 times of that of the medicinal powder I, and collecting distilled ethanol for later use. Centrifuging the concentrated solution in a high speed centrifuge at 8500r/min for 10min, removing precipitate, collecting supernatant, filtering with 0.45 μm organic microporous membrane, removing macromolecular substances, and collecting filtrate as solution I.
Weighing folium Mori, cortex Mori, cacumen Platycladi, herba Macleayae Cordatae, fructus Zanthoxyli and folium Illicii powder according to a certain proportion, mixing well to obtain medicinal powder II, adding 3.5% (by weight) white vinegar 3.5 times of medicinal powder II, soaking for 64h, stirring for 3-5 times during soaking period, filtering after soaking, and collecting vinegar filtrate.
Vacuum concentrating the vinegar filtrate until the weight of the concentrated solution is 1.2 times of the weight of the medicinal powder II, and collecting vinegar distillate; centrifuging the concentrated solution in a high speed centrifuge at 8500r/min for 10min, removing precipitate, collecting supernatant, filtering with 0.45 μm water system microporous membrane to remove macromolecular substances, and collecting filtrate as solution II.
Adding 1% menthol and 1 ‰ borneol into distilled ethanol to obtain menthol and borneol alcoholic solution as solution III.
And combining the solution I and the solution II to obtain a mixed liquid medicine, and performing back dilution on the mixed liquid medicine and the solution III according to the proportion of 1:5 to obtain an itching relieving spray stock solution, namely diluting the mixed liquid medicine and the solution III by 5 times of the solution III based on the total weight of the solution I and the solution II.
Uniformly mixing the itching relieving spray stock solution and the vinegar distillate according to the volume ratio of 3:1:1 to obtain a mixed solution, and adding 0.1 per mill of rose essential oil into the mixed solution to obtain the finished product of the traditional Chinese medicine itching relieving spray.
Example 3: the embodiment provides a traditional Chinese medicine itching relieving spray which is prepared from the following traditional Chinese medicine raw materials of 30 parts of rhizoma atractylodis, 20 parts of mint, 10 parts of asarum, 10 parts of angelica dahurica, 10 parts of cortex mori radicis, 5 parts of rhizoma zingiberis, 20 parts of clove, 5 parts of macleaya cordata, 10 parts of eupatorium, 10 parts of folium mori, 5 parts of hollyhock, 20 parts of cacumen biotae and 20 parts of shikim.
The preparation process comprises the following steps: pulverizing rhizoma Atractylodis, herba Menthae, radix Angelicae Dahuricae, flos Caryophylli, herba Eupatorii, herba asari, Zingiberis rhizoma, folium Mori, cortex Mori, folium Platycladi, herba Macleayae Cordatae, fructus Zanthoxyli, and folium Illicii Lanceolati to 60 mesh respectively.
Weighing rhizoma Atractylodis, herba Menthae, radix Angelicae Dahuricae, flos Caryophylli, herba Eupatorii, herba asari and Zingiberis rhizoma powder according to a certain proportion, mixing well to obtain medicinal powder I, placing into a glass container, adding 75% ethanol solution 9 times the weight of medicinal powder, soaking for 48h, periodically stirring for 3-5 times, filtering after soaking, and collecting alcohol filtrate.
Vacuum concentrating the alcohol filtrate until the weight of the concentrated solution is 0.8 times of that of the medicinal powder I, and collecting distilled ethanol for later use. Centrifuging the concentrated solution in a high speed centrifuge at 7500r/min for 15min, removing precipitate, collecting supernatant, filtering the supernatant with 0.45 μm organic microporous membrane, removing macromolecular substances, and collecting filtrate as solution I.
Weighing folium Mori, cortex Mori, folium Platycladi, herba Macleayae Cordatae, fructus Zanthoxyli and folium Illicii powder according to a certain proportion, mixing well to obtain medicinal powder II, adding 3.5% (v/v) white vinegar 6 times of the medicinal powder II, soaking for 48h, stirring for 3-5 times at regular time during soaking period, filtering after soaking, and collecting vinegar filtrate.
Vacuum concentrating the vinegar filtrate until the weight of the concentrated solution is equal to that of the medicinal powder II, and collecting vinegar distillate; centrifuging the concentrated solution in a high speed centrifuge at 7500r/min for 15min, removing precipitate, collecting supernatant, filtering with 0.45 μm water system microporous membrane to remove macromolecular substances, and collecting filtrate as solution II.
Adding 2% menthol and 1.5 ‰ Borneolum Syntheticum into distilled ethanol to obtain menthol and Borneolum alcoholic solution as solution III.
And combining the solution I and the solution II to obtain a mixed liquid medicine, and performing back dilution on the mixed liquid medicine and the solution III according to the ratio of 1:4 to obtain an itching relieving spray stock solution, namely diluting the mixed liquid medicine and the solution III by 4 times of the solution III based on the total weight of the solution I and the solution II.
Uniformly mixing the itching relieving spray stock solution and the vinegar distillate according to the volume ratio of 3:1:1 to obtain a mixed solution, and adding 0.2 per mill of rose essential oil into the mixed solution to obtain the finished product of the traditional Chinese medicine itching relieving spray.
Effect verification: in order to verify the treatment effect of the traditional Chinese medicine itching relieving spray, 287 patients with different skin diseases are tried out respectively, and the treatment effect is tracked and observed.
The trial method comprises the following steps: the spray is applied externally for 2-3 times a day, 7 days is a treatment course, the spray is effective in treating patients without obvious pruritus, healing skin without complete repair, pruritus and recurrence, and ineffective in improving pruritus, and is used as a judgment standard. The therapeutic effect is shown in table 1.
Figure RE-380886DEST_PATH_IMAGE001
As can be seen from the table 1, the itching relieving spray has the effective rate of 100 percent on seborrheic dermatitis, allergic dermatitis, dermatophytosis, tinea manus and pedis; the effective rate on skin pruritus, neurodermatitis and other diseases is more than 96 percent, and the effective rate on psoriasis is slightly lower than that of other types, but reaches 94 percent, which shows that the itching relieving spray of the invention has better itching relieving effect and can effectively relieve itching.
Typical cases are:
case 1: for a woman in age of 29, the neck back part has eczema and the pruritus is obvious, the itching relieving spray of the invention is sprayed and smeared for 1 day to relieve itching, the skin is completely repaired after 3 days, the skin is repaired completely after 7 days without recurrence, and the comparison chart before and after the use of the spray of the invention (the left chart is before the use, and the right chart is after the use) in the figure 1 shows that the skin after the cure is obviously fine and smooth compared with the skin before the use.
Case 2: case 2: after the traditional Chinese medicine itching relieving spray is applied to a woman in 35 years old and on both legs, the itching and pain of the woman disappear in 3 days, the woman takes effect in 7 days, and the woman is healed in 14 days without relapse, as can be seen in a comparison graph before and after the use of the traditional Chinese medicine itching relieving spray in figure 2 (the left graph is before the use, and the right graph is after the use), the legs are smooth after the healing, and the erythra disappears.
Case 3: after a woman is sprayed with the traditional Chinese medicine itching relieving spray for 18 years old, the itching feeling disappears in 1 day, the skin recovers to a normal state in 3 days and does not relapse, and the phenomena of erythema and edema of the using part obviously disappear as shown by a comparison chart before and after the use of the traditional Chinese medicine itching relieving spray in the figure 3 (the left chart is before the use, and the right chart is after the use).
Case 4: if a male is in the age of 32 and the beriberi of feet is recurrent repeatedly for 5 years, the itching can be relieved in 1 day after the traditional Chinese medicine itching relieving spray is sprayed on the male, the skin can be repaired in 3 days, and the beriberi can be healed in 7 days without recurrence; as can be seen from the comparison of the images before and after use in FIG. 4 (the left image is before use, and the right image is after use), the blisters and broken skin on the foot are obviously disappeared, and the skin on the foot is smooth as if the skin is intact.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and scope of the present invention are intended to be covered thereby.

Claims (7)

1. A traditional Chinese medicine itching relieving spray is characterized in that: the traditional Chinese medicine composition comprises the following traditional Chinese medicine raw materials in parts by weight: 20-30 parts of rhizoma atractylodis, 20-30 parts of mint, 5-10 parts of asarum, 10-20 parts of radix angelicae, 10-20 parts of cortex mori radicis, 5-10 parts of rhizoma zingiberis, 10-20 parts of clove, 5-10 parts of macleaya cordata, 10-20 parts of eupatorium, 10-20 parts of folium mori, 5-10 parts of hollyhock, 10-20 parts of cacumen biotae and 5-10 parts of shikimic.
2. The traditional Chinese medicine itching relieving spray of claim 1, which is characterized in that: the traditional Chinese medicine composition comprises the following traditional Chinese medicine raw materials in parts by weight: 25 parts of rhizoma atractylodis, 25 parts of mint, 8 parts of asarum, 15 parts of angelica dahurica, 15 parts of white mulberry root-bark, 8 parts of rhizoma zingiberis, 15 parts of clove, 8 parts of macleaya cordata, 15 parts of eupatorium fortunei, 15 parts of mulberry leaf, 8 parts of pepper, 15 parts of cacumen biotae and 8 parts of shikimic acid.
3. The traditional Chinese medicine itching relieving spray of claim 1, which is characterized in that: also comprises 1500 portions of 75 percent ethanol solution 1200-400 portions, 400 portions of glycerin 350-400 portions, 400 portions of white vinegar 300-400 portions, 10-15 portions of menthol, 1-1.5 portions of borneol and 0.1-0.2 portion of rose essential oil.
4. A method for preparing the traditional Chinese medicine itching relieving spray of any one of claims 1 to 3, which is characterized in that: the method comprises the following steps:
(1) pulverizing rhizoma Atractylodis, herba Menthae, radix Angelicae Dahuricae, flos Caryophylli, herba Eupatorii, herba asari, Zingiberis rhizoma, folium Mori, cortex Mori, cacumen Platycladi, herba Macleayae Cordatae, fructus Zanthoxyli, and folium Illicii Lanceolati to 40-60 mesh respectively;
(2) weighing rhizoma Atractylodis, herba Menthae, radix Angelicae Dahuricae, flos Caryophylli, herba Eupatorii, herba asari and Zingiberis rhizoma according to a certain proportion, mixing well to obtain medicinal powder I, adding 75% ethanol solution 8-10 times of the weight of medicinal powder I, soaking for 48-72h, stirring for 3-5 times regularly, filtering after soaking, and collecting alcohol filtrate;
(3) vacuum concentrating the alcohol filtrate until the weight of the concentrated solution is 0.8-1.2 times of that of the medicinal powder I, and collecting distilled ethanol for later use; centrifuging the concentrated solution in a high-speed centrifuge at a rotation speed of 7500-;
(4) weighing folium Mori, cortex Mori, folium Platycladi, herba Macleayae Cordatae, fructus Zanthoxyli and folium Illicii Lanceolati according to a certain proportion, mixing well to obtain medicinal powder II, adding 3.5 degree vinegar 3-6 times of medicinal powder II, soaking for 48-72h, stirring for 3-5 times regularly, filtering after soaking, and collecting vinegar filtrate;
(5) vacuum concentrating the vinegar filtrate until the weight of the concentrated solution is 0.8-1.2 times of the weight of the medicinal powder II, and collecting vinegar distillate; placing the concentrated solution in a high-speed centrifuge, centrifuging at low temperature of 7500-;
(6) adding 1% -2% of menthol and 1-1.5% of borneol into the distilled ethanol to prepare an alcoholic solution of the menthol and the borneol as a solution III;
(7) combining the solution I and the solution II to obtain a mixed liquid medicine, and diluting the mixed liquid medicine and the solution III according to the proportion of 1:4-5 to obtain an itching relieving spray stock solution;
(8) and (3) uniformly mixing the itching relieving spray stock solution, the vinegar distillate obtained in the step (5) and glycerol according to the volume ratio of 3:1:1 to obtain a mixed solution, and adding 0.1-0.2 per mill of rose essential oil into the mixed solution to obtain the finished product of the traditional Chinese medicine itching relieving spray.
5. The preparation method of the traditional Chinese medicine itching relieving spray according to claim 4, which is characterized by comprising the following steps: the dipping time of the step (2) and the step (4) is 72 h.
6. The preparation method of the traditional Chinese medicine itching relieving spray according to claim 4, which is characterized by comprising the following steps: and (3) carrying out vacuum concentration on the vinegar filtrate until the weight of the concentrated solution is the same as that of the medicinal powder I.
7. The preparation method of the traditional Chinese medicine itching relieving spray according to claim 4, which is characterized by comprising the following steps: and (5) carrying out vacuum concentration on the vinegar filtrate until the weight of the concentrated solution is the same as that of the medicinal powder II.
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