CN111803590A - A medicinal health product and its preparation method - Google Patents
A medicinal health product and its preparation method Download PDFInfo
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Abstract
The invention belongs to the technical field of medicine and health care, and discloses a medicine and health care product and a preparation method thereof, wherein the medicine and health care product comprises, by mass, 40-45 parts of donkey-hide gelatin, 20-25 parts of a medlar extract, 10-15 parts of a dendrobium officinale extract, 2-5 parts of photosynthetic bacteria powder, 5-10 parts of compound amino acid powder, 2-5 parts of compound vitamin, 2-5 parts of folic acid and 1-3 parts of compound trace element concentrated solution. The invention is rich in various nutrient elements, and meanwhile, by pretreating and extracting various nutrient substances, nutrient molecules in the nutrient substances are decomposed into small molecules which are easily absorbed by a human body, so that the utilization rate of the nutrient elements is improved, and the nutrient substances have the effects of resisting fatigue, controlling blood fat and improving body immunity; meanwhile, the preparation method is simple and can be used for industrial production; the traditional Chinese medicine raw materials with the function of enhancing immunity are screened, the effect is lasting, the raw materials are wide in source, the quality is reliable, and the price is substantial.
Description
Technical Field
The invention belongs to the technical field of medicine and health care, and particularly relates to a medicine and health care product and a preparation method thereof.
Background
At present: in recent years, with the change of life rhythm and the change of food structure of people, people with fatty liver caused by alcoholic liver injury or food structure change due to long-term or large-amount drinking are increasing, and the body health and the stability of families and society of people are seriously influenced. The wine has wide pharmacological action on human bodies, and acute and large-scale drinking can cause nausea, vomiting, hypomnesis, inattention, impaired fine motor ability and unstable mood, and even cause respiratory paralysis to die in severe cases. Long-term drinking can cause mental disorder, damage of immune system, stomach damage, fatty liver, alcoholic hepatitis, liver cirrhosis and other diseases, and data show that the increase of the incidence rate of esophagus cancer and liver cancer seems to be related to drinking.
Aiming at the trend that the incidence rates of fatty liver and alcoholic liver are continuously increased, a plurality of medical institutions strengthen the research on the aspect, the liver institute of the Chinese medical society establishes a fatty liver and alcoholic liver disease group specially, obtains a certain result, determines the diagnosis standard of the alcoholic liver disease, and if the histological characteristics of the alcoholic liver disease are described as follows: the obvious swelling of the liver cells shows ballooning change, particularly liver cells in the centers of lobules, huge mitochondria and the like can be seen in the ballooning-changed liver cells, and the alcoholic liver disease has the obvious characteristic of distinguishing from other liver diseases in medical observation. Fatty liver and alcoholic liver have been regarded as disease species, and have attracted high attention from medical community.
Whether viral hepatitis or chemical liver injury, the liver cell disease is not directly caused by virus invasion, but the liver cell invaded by the virus is attacked by the human immune system, and the virus is eliminated by neutralizing the virus by the antibody produced by the human body. Therefore, if the human immune system infected with hepatitis B virus is normal, antibodies can be generated in time to kill the virus, and the damaged liver cells can be recovered through self-repair. The damage effect of drinking on the immune system of a human body is very obvious, which is the main culprit of converting a plurality of HBV carriers into chronic hepatitis, and more people do not detect hepatitis virus clinically, but a part of people become patients with alcoholic fatty liver, alcoholic hepatic fibrosis and alcoholic severe hepatitis by drinking a large amount of wine for a long time.
Therefore, the development of effective drugs or health foods for alleviating or preventing alcoholic liver injury and regulating body immunity is generally regarded by governments and people.
However, the prior art is not rich in health care products capable of resisting fatigue, reducing fat and regulating body immunity, and the prior health care products are not easy to digest and absorb and have low utilization rate of nutrient elements.
Through the above analysis, the problems and defects of the prior art are as follows: the existing health care products are not easy to digest and absorb, and the utilization rate of nutrient elements is not high.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides a medical health product and a preparation method thereof.
The invention is realized in such a way that the medicine health care product is composed of 40-45 parts of donkey-hide gelatin, 20-25 parts of medlar extract, 10-15 parts of dendrobium officinale extract, 2-5 parts of photosynthetic bacteria powder, 5-10 parts of compound amino acid powder, 2-5 parts of compound vitamin, 2-5 parts of folic acid and 1-3 parts of compound trace element concentrated solution according to the mass parts.
Further, the composite trace element concentrated solution comprises the following components in percentage by weight: 50.49-53.22% of iron, 29.27-31.55% of zinc, 10.64-11.36% of manganese, 0.09-0.11% of chromium, 0.15-0.16% of selenium, 0.25-0.26% of molybdenum and 0.23-0.35% of bromine.
Another object of the present invention is to provide a method for preparing the pharmaceutical and health product, wherein the method for preparing the pharmaceutical and health product comprises:
step one, preparing a medlar extract, a dendrobium officinale extract and a composite trace element concentrated solution; preparing colla Corii Asini into colla Corii Asini polypeptide nutrient solution;
the preparation method of the medlar extract comprises the following steps:
s11, cleaning the medlar, drying, crushing by using a crusher, sieving by using a 200-mesh sieve, and adding 10 times of deionized water for water leaching to obtain medlar leaching liquor;
s12, grinding the obtained wolfberry leaching liquor by using a colloid mill, and homogenizing under the pressure of 270-340 MPa to obtain supernatant and filter residues;
s13, filtering the supernatant to remove impurities to obtain filtrate; adsorbing the filtrate with adsorption resin, eluting with deionized water until no sugar is present, and eluting the fructus Lycii extract adsorbed on the adsorption resin with 70% methanol solvent to obtain fructus Lycii extract eluate;
s14, vacuum concentrating the obtained eluent to obtain a concentrated solution of the Chinese wolfberry extract, and then drying to obtain the Chinese wolfberry extract;
the preparation method of the composite trace element concentrated solution comprises the following steps:
s21, cleaning, airing and crushing a certain amount of palm tree leaves, sieving the palm tree leaves with a 65-mesh sieve, placing the palm tree leaves in an extraction device, flushing supercritical fluid, heating and pressurizing to extract organic trace elements in the palm tree leaves;
s22, separating the supercritical fluid and the trace element extract in a separating device by decompressing and cooling;
s23, sterilizing the separated trace element extract, and then sealing in vacuum to obtain the trace element concentrated solution;
the preparation method of the donkey-hide gelatin polypeptide nutrient solution comprises the following steps:
s31, putting the donkey-hide gelatin and water into a boiling pot, boiling for 30-50 min, and filtering after the donkey-hide gelatin is completely dissolved to obtain a donkey-hide gelatin water solution;
s32, adding collagenase with the weight of 5% of the donkey-hide gelatin aqueous solution into the donkey-hide gelatin aqueous solution for enzymolysis to obtain donkey-hide gelatin hydrolysate;
s33, heating colla Corii Asini hydrolysate in water bath at 70 deg.C for 25-40min, centrifuging with centrifuge, collecting supernatant, and sterilizing with ultraviolet sterilizer;
s34, filtering the sterilized donkey-hide gelatin hydrolysate under an ultrafiltration membrane to obtain the donkey-hide gelatin polypeptide liquid;
step two, uniformly mixing the prepared medlar extract, the prepared dendrobium officinale extract, the photosynthetic bacteria powder, the compound amino acid powder, the compound vitamin and the folic acid, and performing sterilization treatment by using an ultraviolet sterilization device to obtain mixed powder;
and step three, mixing the obtained mixed powder with the compound trace element concentrated solution and the donkey-hide gelatin polypeptide nutrient solution, adding a binding agent, granulating, drying, sterilizing, and preparing capsules (including soft capsules), pills (including dropping pills), granules, tablets, granules, injection or oral liquid.
Further, in step S21, the extraction parameters of the extraction device include: the extraction temperature is 60-75 ℃, the pressure is 46-53 MPa, and the extraction time is 6 h.
Further, in step S21, the flow rate of the supercritical fluid required per 1kg of palm tree leaves is 25L/min, and the supercritical fluid is one or more mixed gases of nitrogen, carbon dioxide, air and argon.
Further, in step S32, the enzymatic hydrolysis includes: the enzymolysis temperature is 50-60 ℃, and the enzymolysis time is 3.5-4.5 h.
Further, in the third step, the adhesive is one of an ethanol solution of 5-10% polyvinylpyrrolidone and an ethanol solution of 95%.
Further, the dendrobium officinale extract is prepared by coarsely crushing dried dendrobium officinale stems, carrying out water extraction, and concentrating an extracting solution into a fluid extract; precipitating with 90% edible ethanol 3 times the weight of the fluid extract, recovering ethanol from the supernatant, oven drying the precipitate, and pulverizing.
Further, the water leaching is to leach 2 times by using water with the weight 8-10 times of that of the dendrobium officinale, the leaching time is 50min, and the leaching temperature is 80-90 ℃; the concentration temperature is 95-100 ℃.
Further, the ethanol is kept stand for 24 hours during precipitation, the precipitation is repeated twice, the drying temperature is 70-80 ℃, and the fine powder is sieved by a 200-mesh sieve.
By combining all the technical schemes, the invention has the advantages and positive effects that:
the invention is rich in various nutrient elements, and meanwhile, by pretreating and extracting various nutrient substances, nutrient molecules in the nutrient substances are decomposed into small molecules which are easily absorbed by a human body, so that the utilization rate of the nutrient elements is improved, and the nutrient substances have the effects of resisting fatigue, controlling blood fat and improving body immunity; meanwhile, the preparation method is simple and can be used for industrial production.
The product provided by the invention is a natural health food, combines a large amount of functional documents and clinical documents, screens the traditional Chinese medicine raw materials with the function of enhancing the immunity, and has the advantages of lasting effect, wide raw material sources, reliable quality and low price. The raw materials of the health-care food are all raw materials which are specified by China and can be used for health-care food, no incompatibility exists among the raw materials, the synergistic effect is achieved when the raw materials are used in a matched mode, the donkey-hide gelatin is used as a main raw material and has the effect of enhancing the immunity, and materials with the obvious effect of enhancing the immunity, such as a medlar extract, a dendrobium officinale extract, compound amino acid powder and the like, are used as auxiliary materials, so that the health-care function of enhancing the immunity of the health-care food is improved.
The dendrobium officinale has sweet taste and slightly cold nature and taste. Promoting the production of body fluid and nourishing the stomach; nourishing yin and clearing heat; moistening lung and invigorating kidney; improving eyesight and strengthening waist; reducing blood sugar, and enhancing immunity.
Amino acids are essential substances in human life movement, and have the physiological effects of promoting protein synthesis, collagen protein and growth hormone secretion, protecting liver function, preventing liver function damage after drinking, beautifying skin, relieving fatigue, stimulating appetite, improving immunity of organism, promoting rehabilitation after illness and parturition, regulating endocrine, increasing brain function, relieving fatigue, and benefiting human body.
Donkey-hide gelatin, name of Chinese medicinal material. The product is a glue block prepared by removing hair from donkey skin of Equidae and decocting. The animal morphology is detailed donkey meat strips. The main functional indications are as follows: nourish yin and enrich blood, prevent abortion. It is indicated for blood deficiency, cough due to asthenia, hematemesis, epistaxis, hematochezia, female irregular menstruation, metrorrhagia, fetal leakage. (I) Ben Jing: mainly cause heart and abdominal metrorrhagia, fatigue and sprinkling as malaria, waist and abdominal pain, soreness and pain of limbs, and female bleeding. Preventing miscarriage. Can be taken for a long time to replenish qi. ② Biyu (miscellaneous records): the husband has lower abdominal pain, asthenia, emaciation, yin-qi deficiency, and soreness of feet, and can nourish liver-qi. ③ treatise on herb Property: strengthen tendons and bones, tonify qi and stop dysentery. Fourthly, Qianjin dietotherapy: it is indicated for strong wind. Fifth, washing: for treating wind-toxin-cutting bone joint pain, groaning and non-curing, it is taken with ease. Sixthly, the book of Japanese Huazi materia Medica: it is indicated for rhinorrhea with rapid onset of pathogenic wind, hematemesis, intestinal wind, bloody dysentery, metrorrhagia, leukorrhagia. Seventh, the compendium: can be used for treating hematemesis, epistaxis, bloody stranguria, hematuria, intestinal wind, and dysentery. Female blood pain, blood withering, irregular menstruation, no seed, metrorrhagia, leukorrhagia, prenatal and postnatal diseases. All wind diseases of men and women, bone joint pain, edema of water and gas, consumptive disease, cough, dyspnea, consumptive lung disease, saliva, bloody pus and carbuncle, cellulitis and pyogenic infections. Harmonizing blood and nourishing yin, dispelling pathogenic wind and moistening dryness, eliminating phlegm and clearing lung-heat, promoting urination, and regulating large intestine. Eighthly, compendium supplement: for lumbago due to internal injury, strengthening tendons and tendons, replenishing essence to strengthen kidney.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings needed to be used in the embodiments of the present application will be briefly described below, and it is obvious that the drawings described below are only some embodiments of the present application, and it is obvious for those skilled in the art that other drawings can be obtained from the drawings without creative efforts.
Fig. 1 is a flow chart of a method for preparing a health product in accordance with an embodiment of the present invention.
Fig. 2 is a flow chart of a method for preparing an extract of lycium barbarum provided by an embodiment of the invention.
Fig. 3 is a flow chart of a method for preparing a composite trace element concentrated solution according to an embodiment of the present invention.
Fig. 4 is a flow chart of a preparation method of the donkey-hide gelatin polypeptide nutrient solution provided by the embodiment of the invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Aiming at the problems in the prior art, the invention provides a medical health product and a preparation method thereof, and the invention is described in detail with reference to the accompanying drawings.
The medical health-care product provided by the embodiment of the invention comprises, by mass, 40-45 parts of donkey-hide gelatin, 20-25 parts of a wolfberry extract, 10-15 parts of a dendrobium officinale extract, 2-5 parts of photosynthetic bacteria powder, 5-10 parts of composite amino acid powder, 2-5 parts of composite vitamin, 2-5 parts of folic acid and 1-3 parts of composite trace element concentrated solution.
The composite trace element concentrated solution provided by the embodiment of the invention comprises the following components in percentage by weight: 50.49-53.22% of iron, 29.27-31.55% of zinc, 10.64-11.36% of manganese, 0.09-0.11% of chromium, 0.15-0.16% of selenium, 0.25-0.26% of molybdenum and 0.23-0.35% of bromine.
As shown in fig. 1, the preparation method of the health product provided by the embodiment of the present invention includes:
s101, preparing a medlar extract, a dendrobium officinale extract and a composite trace element concentrated solution; preparing colla Corii Asini into colla Corii Asini polypeptide nutrient solution;
s102, uniformly mixing the prepared wolfberry extract, the dendrobium officinale extract, the photosynthetic bacteria powder, the compound amino acid powder, the compound vitamin and the folic acid, and performing sterilization treatment by using an ultraviolet sterilization device to obtain mixed powder;
s103, mixing the obtained mixed powder with the compound trace element concentrated solution and the donkey-hide gelatin polypeptide nutrient solution, adding a binding agent, granulating, drying, sterilizing, and preparing into capsules (including soft capsules), pills (including dropping pills), granules, tablets, granules, injection or oral liquid.
As shown in fig. 2, in step S101, the method for preparing an extract of lycium barbarum provided by the embodiment of the present invention includes:
s201, cleaning and drying the medlar, crushing the medlar by using a crusher, sieving the medlar by using a 200-mesh sieve, and adding 10 times of deionized water for water leaching to obtain medlar leaching liquor.
S202, grinding the obtained wolfberry leaching liquor by using a colloid mill, and homogenizing under the pressure of 270-340 MPa to obtain supernatant and filter residue.
S203, filtering the supernatant to remove impurities to obtain a filtrate; adsorbing the filtrate with adsorbent resin, eluting with deionized water until no sugar is present, and eluting the fructus Lycii extract adsorbed on the adsorbent resin with 70% methanol solvent to obtain fructus Lycii extract eluate.
S204, vacuum-concentrating the obtained eluent to obtain a concentrated solution of the Chinese wolfberry extract, and then drying to obtain the Chinese wolfberry extract.
As shown in fig. 3, in step S101, the method for preparing the composite trace element concentrated solution according to the embodiment of the present invention includes:
s301, cleaning, airing and crushing 1kg of palm tree leaves, sieving the palm tree leaves with a 65-mesh sieve, placing the palm tree leaves in an extraction device, flushing supercritical fluid, heating and pressurizing, and extracting organic trace elements in the palm tree leaves.
And S302, in the separation device, reducing the pressure and the temperature to separate the supercritical fluid from the trace element extract.
S303, sterilizing the separated trace element extract, and then sealing in vacuum to obtain the trace element concentrated solution.
In step S301, the extraction parameters provided in the embodiment of the present invention include: the extraction temperature is 60-75 ℃, the pressure is 46-53 MPa, and the extraction time is 6 h.
In step S301, the flow rate of the supercritical fluid required for each 1kg of palm tree leaves in the embodiment of the present invention is 25L/min. The supercritical fluid is one or more of nitrogen, carbon dioxide, air and argon.
As shown in fig. 4, in step S101, the preparation method of the donkey-hide gelatin polypeptide nutrient solution provided by the embodiment of the present invention includes:
s401, putting donkey-hide gelatin and water into a boiling pot, boiling for 30-50 min, and filtering after the donkey-hide gelatin is completely dissolved to obtain a donkey-hide gelatin water solution;
s402, adding collagenase with the weight of 5% of the donkey-hide gelatin aqueous solution into the donkey-hide gelatin aqueous solution for enzymolysis to obtain donkey-hide gelatin hydrolysate;
s403, heating colla Corii Asini hydrolysate in water bath at 70 deg.C for 25-40min, centrifuging with centrifuge, collecting supernatant, and sterilizing with ultraviolet sterilizer;
s404, filtering the sterilized donkey-hide gelatin hydrolysate under an ultrafiltration membrane to obtain the donkey-hide gelatin polypeptide liquid.
The enzymolysis provided by the embodiment of the invention comprises the following steps: the enzymolysis temperature is 50-60 ℃, and the enzymolysis time is 3.5-4.5 h.
The technical solution of the present invention is further illustrated by the following specific examples.
Example 1:
the preparation method of the medical health product comprises the following steps:
step one, preparing a medlar extract, a dendrobium officinale extract and a composite trace element concentrated solution; preparing colla Corii Asini into colla Corii Asini polypeptide nutrient solution;
step two, uniformly mixing 20 parts of the prepared medlar extract, 10 parts of the dendrobium officinale extract, 2 parts of photosynthetic bacteria powder, 5 parts of compound amino acid powder, 2 parts of compound vitamin and 2 parts of folic acid, and performing sterilization treatment by using an ultraviolet sterilization device to obtain mixed powder;
and step three, mixing the obtained mixed powder with 1 part of the compound trace element concentrated solution and 40 parts of the donkey-hide gelatin polypeptide nutrient solution, adding an adhesive, granulating, drying, sterilizing and preparing into capsules.
Example 2:
the preparation method of the medical health product comprises the following steps:
step one, preparing a medlar extract, a dendrobium officinale extract and a composite trace element concentrated solution; preparing colla Corii Asini into colla Corii Asini polypeptide nutrient solution;
step two, uniformly mixing 22 parts of the prepared medlar extract, 23 parts of the prepared dendrobium officinale extract, 4 parts of photosynthetic bacteria powder, 8 parts of compound amino acid powder, 4 parts of compound vitamin and 4 parts of folic acid, and performing sterilization treatment by using an ultraviolet sterilization device to obtain mixed powder;
and step three, mixing the obtained mixed powder with 2 parts of compound trace element concentrated solution and 44 parts of donkey-hide gelatin polypeptide nutrient solution, adding a binding agent, granulating, drying, sterilizing and preparing into granules.
Example 3:
the preparation method of the medical health product comprises the following steps:
step one, preparing a medlar extract, a dendrobium officinale extract and a composite trace element concentrated solution; preparing colla Corii Asini into colla Corii Asini polypeptide nutrient solution;
step two, uniformly mixing 25 parts of the prepared medlar extract, 15 parts of the dendrobium officinale extract, 5 parts of photosynthetic bacteria powder, 8 parts of compound amino acid powder, 5 parts of compound vitamin and 5 parts of folic acid, and performing sterilization treatment by using an ultraviolet sterilization device to obtain mixed powder;
and step three, mixing the obtained mixed powder with 3 parts of compound trace element concentrated solution and 45 parts of donkey-hide gelatin polypeptide nutrient solution, adding a binding agent, granulating, drying, sterilizing and preparing the oral liquid.
The effects of the present invention will be further described below with reference to pharmacological analyses of the drugs of the present invention.
Donkey-hide gelatin, name of Chinese medicinal material. The product is a glue block prepared by removing hair from donkey skin of Equidae and decocting. The animal morphology is detailed donkey meat strips. The main functional indications are as follows: nourish yin and enrich blood, prevent abortion. It is indicated for blood deficiency, cough due to asthenia, hematemesis, epistaxis, hematochezia, female irregular menstruation, metrorrhagia, fetal leakage. (I) Ben Jing: mainly cause heart and abdominal metrorrhagia, fatigue and sprinkling as malaria, waist and abdominal pain, soreness and pain of limbs, and female bleeding. Preventing miscarriage. Can be taken for a long time to replenish qi. ② Biyu (miscellaneous records): the husband has lower abdominal pain, asthenia, emaciation, yin-qi deficiency, and soreness of feet, and can nourish liver-qi. ③ treatise on herb Property: strengthen tendons and bones, tonify qi and stop dysentery. Fourthly, Qianjin dietotherapy: it is indicated for strong wind. Fifth, washing: for treating wind-toxin-cutting bone joint pain, groaning and non-curing, it is taken with ease. Sixthly, the book of Japanese Huazi materia Medica: it is indicated for rhinorrhea with rapid onset of pathogenic wind, hematemesis, intestinal wind, bloody dysentery, metrorrhagia, leukorrhagia. Seventh, the compendium: can be used for treating hematemesis, epistaxis, bloody stranguria, hematuria, intestinal wind, and dysentery. Female blood pain, blood withering, irregular menstruation, no seed, metrorrhagia, leukorrhagia, prenatal and postnatal diseases. All wind diseases of men and women, bone joint pain, edema of water and gas, consumptive disease, cough, dyspnea, consumptive lung disease, saliva, bloody pus and carbuncle, cellulitis and pyogenic infections. Harmonizing blood and nourishing yin, dispelling pathogenic wind and moistening dryness, eliminating phlegm and clearing lung-heat, promoting urination, and regulating large intestine. Eighthly, compendium supplement: for lumbago due to internal injury, strengthening tendons and tendons, replenishing essence to strengthen kidney.
The fructus Lycii extract can improve immunity and enhance the ability of body to adapt to various harmful stimuli; can inhibit the generation and spread of cancer cells; improving eyesight; the energy of the human body is increased and the anti-fatigue effect is achieved; improving brain function, and enhancing learning and memory ability; preventing symptoms such as anoxia, common cold, and blood loss; the hematopoietic function of the body is enhanced by promoting the propagation of hematopoietic cells and increasing the white blood cell count; effectively enhancing the functions of various organs, improving the brain function, resisting free radicals as an antioxidant and delaying aging; can significantly reduce serum cholesterol and triglyceride levels, and reduce and prevent arteriosclerosis and hypertension; can relieve allergic symptoms such as gastrointestinal hemorrhage and arthralgia. This effect is achieved by regulating endocrine; protecting the liver and nourishing the kidney by inhibiting the deposition of fat in the liver cells and promoting the regeneration of the liver cells; the contained guanidine derivative can reduce blood sugar, and can be used as health product for diabetic.
The dendrobium officinale has sweet taste and slightly cold nature and taste. Promoting the production of body fluid and nourishing the stomach; nourishing yin and clearing heat; moistening lung and invigorating kidney; improving eyesight and strengthening waist. Also has the following pharmacological actions:
promoting the secretion of saliva: the dendrobium officinale has the effect of promoting the production of body fluid and is mainly characterized by promoting glandular secretion and organ movement.
The hypoglycemic effect: the dendrobium officinale can reduce the value of blood sugar induced by streptozotocin.
Enhancing the immunity of the organism: the dendrobium officinale granules (TPSH) can promote the phagocytic function of macrophages of tumor-bearing animals, enhance the proliferation and differentiation of T lymphocytes and the activity of NK cells, and can obviously improve the serum hemolysin value of the tumor-bearing animals, thereby prompting that the TPSH has certain improvement effect on nonspecific immune function or specific cellular immune and humoral immune function.
And the dendrobium officinale mainly contains dendrobium polysaccharide, dendrobium phenanthrene phenol, dendrobine and other ingredients, and the dendrobium phenanthrene phenol compound is a general name of dendrobium phenanthrenes and dendrobium phenols and is a characteristic ingredient in dendrobium plants. The Dendrobium officinale polysaccharide has the effects of preventing and treating metabolic syndrome, preventing hypertension and apoplexy, preventing arthritis, protecting digestive tract mucosa, resisting depression and tumors, regulating immunity and the like.
The functions of compound amino acid are as follows: 1. enhancing immunity and nutrition absorption; 2. relieving various adverse symptoms caused by brain fatigue and insufficient sleep of a brain worker; 3. the liver function, the kidney function and the gastrointestinal function are all improved well; 4. promoting intelligence development of children, and improving memory.
The main components of the compound amino acid comprise 18 amino acids such as glycine, alanine, leucine, isoleucine, valine, cystine, cysteine, methionine, threonine, serine, phenylalanine, tyrosine, tryptophan, proline, hydroxyproline, glutamic acid, aspartic acid and the like. Amino acids are essential substances in human life movement, and have the physiological effects of promoting protein synthesis, collagen protein and growth hormone secretion, protecting liver function, preventing liver function damage after drinking, beautifying skin, relieving fatigue, stimulating appetite, improving immunity of organism, promoting rehabilitation after illness and parturition, regulating endocrine, increasing brain function, relieving fatigue, and benefiting human body.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention, and the scope of the present invention is not limited thereto, and any modification, equivalent replacement, and improvement made by those skilled in the art within the technical scope of the present invention disclosed herein, which is within the spirit and principle of the present invention, should be covered by the present invention.
Claims (10)
1. The preparation method of the medical health product is characterized by comprising the following steps:
step one, preparing a medlar extract, a dendrobium officinale extract and a composite trace element concentrated solution; preparing colla Corii Asini into colla Corii Asini polypeptide nutrient solution;
the preparation method of the medlar extract comprises the following steps:
s11, cleaning the medlar, drying, crushing by using a crusher, sieving by using a 200-mesh sieve, and adding 10 times of deionized water for water leaching to obtain medlar leaching liquor;
s12, grinding the obtained wolfberry leaching liquor by using a colloid mill, and homogenizing under the pressure of 270-340 MPa to obtain supernatant and filter residues;
s13, filtering the supernatant to remove impurities to obtain filtrate; adsorbing the filtrate with adsorption resin, eluting with deionized water until no sugar is present, and eluting the fructus Lycii extract adsorbed on the adsorption resin with 70% methanol solvent to obtain fructus Lycii extract eluate;
s14, vacuum concentrating the obtained eluent to obtain a concentrated solution of the Chinese wolfberry extract, and then drying to obtain the Chinese wolfberry extract;
the preparation method of the composite trace element concentrated solution comprises the following steps:
s21, cleaning, airing and crushing a certain amount of palm tree leaves, sieving the palm tree leaves with a 65-mesh sieve, placing the palm tree leaves in an extraction device, flushing supercritical fluid, heating and pressurizing to extract organic trace elements in the palm tree leaves;
s22, separating the supercritical fluid and the trace element extract in a separating device by decompressing and cooling;
s23, sterilizing the separated trace element extract, and then sealing in vacuum to obtain the trace element concentrated solution;
the preparation method of the donkey-hide gelatin polypeptide nutrient solution comprises the following steps:
s31, putting the donkey-hide gelatin and water into a boiling pot, boiling for 30-50 min, and filtering after the donkey-hide gelatin is completely dissolved to obtain a donkey-hide gelatin water solution;
s32, adding collagenase with the weight of 5% of the donkey-hide gelatin aqueous solution into the donkey-hide gelatin aqueous solution for enzymolysis to obtain donkey-hide gelatin hydrolysate;
s33, heating colla Corii Asini hydrolysate in water bath at 70 deg.C for 25-40min, centrifuging with centrifuge, collecting supernatant, and sterilizing with ultraviolet sterilizer;
s34, filtering the sterilized donkey-hide gelatin hydrolysate under an ultrafiltration membrane to obtain the donkey-hide gelatin polypeptide liquid;
step two, uniformly mixing the prepared medlar extract, the prepared dendrobium officinale extract, the photosynthetic bacteria powder, the compound amino acid powder, the compound vitamin and the folic acid, and performing sterilization treatment by using an ultraviolet sterilization device to obtain mixed powder;
and step three, mixing the obtained mixed powder with the compound trace element concentrated solution and the donkey-hide gelatin polypeptide nutrient solution, adding a binding agent, granulating, drying, sterilizing, and preparing capsules, pills, granules, tablets, granules, injection or oral liquid.
2. The method for preparing a health product according to claim 1, wherein in step S21, the extraction parameters of the extraction device include: the extraction temperature is 60-75 ℃, the pressure is 46-53 MPa, and the extraction time is 6 h.
3. The method for preparing a health product according to claim 1, wherein in step S21, the flow rate of the supercritical fluid per 1kg of palm tree leaves is 25L/min, and the supercritical fluid is one or more of nitrogen, carbon dioxide, air and argon.
4. The method for preparing a pharmaceutical composition according to claim 1, wherein in step S32, the enzymatic hydrolysis comprises: the enzymolysis temperature is 50-60 ℃, and the enzymolysis time is 3.5-4.5 h.
5. The method for preparing a medicinal health product according to claim 1, wherein the Dendrobium officinale extract is obtained by coarsely pulverizing dried Dendrobium officinale stems, leaching with water, and concentrating the extractive solution to obtain fluid extract; precipitating with 90% edible ethanol 3 times the weight of the fluid extract, recovering ethanol from the supernatant, oven drying the precipitate, and pulverizing.
6. The method for preparing a medicinal health product according to claim 5, wherein the water leaching is performed for 2 times by using water with the weight 8-10 times of that of the dendrobium officinale, the leaching time is 50min, and the leaching temperature is 80-90 ℃; the concentration temperature is 95-100 ℃.
7. The process for preparing a pharmaceutical composition according to claim 5, wherein the ethanol precipitation is repeated twice after standing for 24 hours at a drying temperature of 70 to 80 ℃ and the fine powder is passed through a 200 mesh sieve.
8. The method for preparing a health product according to claim 1, wherein in step three, the binder is one of an ethanol solution of 5-10% polyvinylpyrrolidone and an ethanol solution of 95%.
9. The medical health-care product prepared by the preparation method of the medical health-care product according to any one of claims 1 to 8 is characterized by comprising, by mass, 40 to 45 parts of donkey-hide gelatin, 20 to 25 parts of a medlar extract, 10 to 15 parts of a dendrobium officinale extract, 2 to 5 parts of photosynthetic bacteria powder, 5 to 10 parts of composite amino acid powder, 2 to 5 parts of composite vitamin, 2 to 5 parts of folic acid and 1 to 3 parts of composite trace element concentrated solution.
10. The medical health product as claimed in claim 9, wherein the composite microelement concentrate comprises, in weight percent: 50.49-53.22% of iron, 29.27-31.55% of zinc, 10.64-11.36% of manganese, 0.09-0.11% of chromium, 0.15-0.16% of selenium, 0.25-0.26% of molybdenum and 0.23-0.35% of bromine.
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