CN111803419A - Composition with skin whitening and moisturizing effects, preparation method and use method - Google Patents
Composition with skin whitening and moisturizing effects, preparation method and use method Download PDFInfo
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- CN111803419A CN111803419A CN202010767606.3A CN202010767606A CN111803419A CN 111803419 A CN111803419 A CN 111803419A CN 202010767606 A CN202010767606 A CN 202010767606A CN 111803419 A CN111803419 A CN 111803419A
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- 239000000203 mixture Substances 0.000 title claims abstract description 26
- 230000002087 whitening effect Effects 0.000 title claims abstract description 18
- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 12
- 238000000034 method Methods 0.000 title claims description 19
- 238000002360 preparation method Methods 0.000 title claims description 15
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 57
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 47
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 38
- 239000009910 sargent gloryvine Substances 0.000 claims abstract description 35
- 239000000284 extract Substances 0.000 claims abstract description 30
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims abstract description 22
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 19
- 235000011187 glycerol Nutrition 0.000 claims abstract description 19
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims abstract description 19
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims abstract description 19
- 239000011780 sodium chloride Substances 0.000 claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- 241000220317 Rosa Species 0.000 claims abstract description 15
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000011726 vitamin B6 Substances 0.000 claims abstract description 11
- 235000019158 vitamin B6 Nutrition 0.000 claims abstract description 11
- 229940011671 vitamin b6 Drugs 0.000 claims abstract description 11
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 6
- 229960000633 dextran sulfate Drugs 0.000 claims abstract description 6
- 239000011734 sodium Substances 0.000 claims abstract description 6
- 229910052708 sodium Inorganic materials 0.000 claims abstract description 6
- 230000000694 effects Effects 0.000 claims abstract description 5
- 238000003756 stirring Methods 0.000 claims description 40
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 32
- 239000000706 filtrate Substances 0.000 claims description 24
- 238000001914 filtration Methods 0.000 claims description 16
- 238000002137 ultrasound extraction Methods 0.000 claims description 16
- 229920003045 dextran sodium sulfate Polymers 0.000 claims description 13
- 239000000843 powder Substances 0.000 claims description 11
- 229960005150 glycerol Drugs 0.000 claims description 8
- 229930003231 vitamin Natural products 0.000 claims description 7
- 239000011782 vitamin Substances 0.000 claims description 7
- 235000013343 vitamin Nutrition 0.000 claims description 7
- 229940088594 vitamin Drugs 0.000 claims description 7
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 7
- 241000628997 Flos Species 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 235000013361 beverage Nutrition 0.000 claims description 2
- 230000036564 melanin content Effects 0.000 abstract description 8
- 230000007794 irritation Effects 0.000 abstract description 3
- 230000015572 biosynthetic process Effects 0.000 abstract description 2
- 238000001035 drying Methods 0.000 abstract description 2
- 230000019612 pigmentation Effects 0.000 abstract description 2
- 235000013772 propylene glycol Nutrition 0.000 abstract description 2
- 230000004044 response Effects 0.000 abstract description 2
- 235000015424 sodium Nutrition 0.000 abstract description 2
- 235000002639 sodium chloride Nutrition 0.000 abstract description 2
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 238000012360 testing method Methods 0.000 description 28
- 230000000052 comparative effect Effects 0.000 description 10
- 239000003814 drug Substances 0.000 description 8
- 239000002537 cosmetic Substances 0.000 description 7
- 229940079593 drug Drugs 0.000 description 7
- 239000000523 sample Substances 0.000 description 6
- 239000000047 product Substances 0.000 description 5
- 208000026935 allergic disease Diseases 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 3
- 239000005556 hormone Substances 0.000 description 3
- 229940088597 hormone Drugs 0.000 description 3
- 208000023275 Autoimmune disease Diseases 0.000 description 2
- NOQGZXFMHARMLW-UHFFFAOYSA-N Daminozide Chemical compound CN(C)NC(=O)CCC(O)=O NOQGZXFMHARMLW-UHFFFAOYSA-N 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 208000029462 Immunodeficiency disease Diseases 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000002354 daily effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000007813 immunodeficiency Effects 0.000 description 2
- 229960003444 immunosuppressant agent Drugs 0.000 description 2
- 239000003018 immunosuppressive agent Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 206010006784 Burning sensation Diseases 0.000 description 1
- 241000345998 Calamus manan Species 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 241000501113 Sargentodoxa cuneata Species 0.000 description 1
- 206010040844 Skin exfoliation Diseases 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 229940124599 anti-inflammatory drug Drugs 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000035618 desquamation Effects 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 235000012950 rattan cane Nutrition 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000001054 red pigment Substances 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000036561 sun exposure Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Abstract
The invention provides a composition with skin whitening and moisturizing effects, which consists of sargentgloryvine stem extract, rose hydrosol, glycerin, vitamin B6, propylene glycol, sodium chloride, sodium carboxymethylcellulose, sodium dextran sulfate and water. The invention has no irritation to skin, no toxic and side effects, safety and effectiveness. The invention has convenient use and quick response time, can effectively improve the fair skin degree, reduce the melanin content in the skin, inhibit the formation of pigmentation, and effectively lock the skin moisture, thereby preventing the skin from drying.
Description
Technical Field
The invention relates to the field of cosmetic skin care, in particular to a composition with skin whitening and moisturizing effects, a preparation method and a use method.
Background
With the improvement of living standard, people seek more diversified ways for beauty, and have higher attention on whitening skin care products developed by natural medicines. At present, the new generation of whitening skin care products pay more attention to compounding of various whitening active substances to generate a synergistic effect. The whitening components extracted from Chinese herbal medicines are gradually hot in the cosmetic industry due to the characteristics of mild skin, small irritation, stable drug property, high safety, lasting drug efficacy and the like.
In recent years, sargentgloryvine stem is beginning to be applied to health food and traditional medicine industries, in particular to the preparation of medicines for treating rheumatism and promoting blood circulation to remove blood stasis, but the application of sargentgloryvine stem in the aspect of cosmetic whitening is rarely reported.
At present, a composition which takes sargentgloryvine stem as a raw material and has the effects of whitening skin and moisturizing is not found.
Disclosure of Invention
The invention aims to provide a composition with skin whitening and moisturizing effects and a using method thereof.
In order to achieve the purpose, the invention provides a composition with skin whitening and moisturizing effects, which consists of sargentgloryvine stem extract, rose hydrosol, glycerin, vitamin B6, propylene glycol, sodium chloride, sodium carboxymethylcellulose, sodium dextran sulfate and water.
Preferably, the composition consists of 25-35 wt% of sargentgloryvine stem extract, 10-15 wt% of rose hydrosol, 10-15 wt% of glycerin, 63-5 wt% of vitamin B, 2-3 wt% of propylene glycol, 2-3 wt% of sodium chloride, 1-2 wt% of sodium carboxymethylcellulose, 1-2 wt% of sodium dextran sulfate and water which are supplemented to 100 wt%.
In one embodiment, the composition consists of sargentgloryvine stem extract 25 wt%, rose hydrosol 10 wt%, glycerin 15 wt%, vitamin B65 wt wt%, propylene glycol 3 wt%, sodium chloride 3 wt%, sodium carboxymethyl cellulose 1 wt%, dextran sodium sulfate 1 wt%, and water supplemented to 100 wt%.
In one embodiment, the composition consists of sargentgloryvine stem extract 30 wt%, rose hydrosol 15 wt%, glycerin 10 wt%, vitamin B64 wt wt%, propylene glycol 2 wt%, sodium chloride 2 wt%, sodium carboxymethyl cellulose 2 wt%, dextran sodium sulfate 1 wt%, and water supplemented to 100 wt%.
In one embodiment, the composition consists of sargentgloryvine stem extract 35 wt%, rose hydrosol 15 wt%, glycerin 10 wt%, vitamin B63 wt wt%, propylene glycol 2 wt%, sodium chloride 2 wt%, sodium carboxymethyl cellulose 1 wt%, dextran sodium sulfate 2 wt%, and water supplemented to 100 wt%.
The invention also provides a composition with skin whitening and moisturizing effects, and the method comprises the following steps:
(1) adding 25-35 parts of sargentgloryvine stem medicinal powder into 10-15 times of 50-75% ethanol, performing ultrasonic extraction for 30-40 min, and filtering to obtain filtrate a; adding 10-15 times of 50-75% ethanol for the second time, performing ultrasonic extraction for 30-40 min, and filtering to obtain a filtrate b; combining the two filtrates, and concentrating under reduced pressure to 0.3-0.5 g/mL to obtain a sargentgloryvine stem extract;
(2) adding water with the temperature of 40-50 ℃ according to the formula proportion into a preparation container, and starting stirring;
(3) sequentially adding the sargentgloryvine stem extract obtained in the step (1), sodium chloride and propylene glycol, and continuously stirring for 10-20 min;
(4) sequentially adding glycerol, vitamin B6 and dextran sodium sulfate, and continuously stirring for 20-30 min;
(5) sequentially adding rose hydrosol and sodium carboxymethylcellulose, continuously stirring for 10-20 min, and stopping stirring to obtain the rose beverage.
In some of these embodiments, the method comprises the steps of:
(1) adding 35 parts of sargentgloryvine stem medicinal powder into 75% ethanol 15 times the amount of the sargentgloryvine stem medicinal powder, performing ultrasonic extraction for 40min, and filtering to obtain filtrate a; adding 75% ethanol with 10 times of the total volume of the extract for the second time, performing ultrasonic extraction for 30min, and filtering to obtain filtrate b; mixing the two filtrates, and concentrating under reduced pressure to 0.5g/mL to obtain caulis Sargentodoxae extract;
(2) adding water with the temperature of 40 ℃ according to the formula proportion into a preparation container, and starting stirring;
(3) sequentially adding the sargentgloryvine stem extract obtained in the step (1), sodium chloride and propylene glycol, and continuously stirring for 10 min;
(4) sequentially adding glycerol, vitamin B6, and dextran sodium sulfate, and stirring for 20 min;
(5) sequentially adding flos Rosae Rugosae hydrosol and sodium carboxymethylcellulose, stirring for 10min, and stopping stirring.
In some of these embodiments, the method comprises the steps of:
(1) adding 25 parts of sargentgloryvine stem medicinal powder into 15 times of 50% ethanol, performing ultrasonic extraction for 40min, and filtering to obtain filtrate a; adding 10 times of 50% ethanol for the second time, performing ultrasonic extraction for 30min, and filtering to obtain filtrate b; mixing the two filtrates, and concentrating under reduced pressure to 0.3g/mL to obtain caulis Sargentodoxae extract;
(2) adding water with the temperature of 50 ℃ according to the formula proportion into a preparation container, and starting stirring;
(3) sequentially adding the sargentgloryvine stem extract obtained in the step (1), sodium chloride and propylene glycol, and continuously stirring for 20 min;
(4) sequentially adding glycerol, vitamin B6, and dextran sodium sulfate, and stirring for 30 min;
(5) sequentially adding flos Rosae Rugosae hydrosol and sodium carboxymethylcellulose, stirring for 20min, and stopping stirring.
The invention also provides a use method of the composition with the effects of whitening and moisturizing the skin, wherein the composition is used every day for at least 2 weeks.
Preferably, the method is such that the composition is administered daily for at least 4 weeks.
The medicinal material sargentgloryvine stem used by the invention is dry rattan stem derived from Sargentodoxa cuneata (Oliv.) Rehd. et Wils.
Compared with the prior art, the invention has the following beneficial effects:
1. the invention has no irritation to skin, no toxic and side effects, safety and effectiveness.
2. The invention has convenient use and quick response time, can effectively improve the fair degree of skin, reduce the melanin content in the skin and inhibit the formation of pigmentation.
3. The invention can effectively lock the moisture of the skin and prevent the skin from drying.
Detailed Description
Example 1
(1) Adding 35g of sargentgloryvine stem medicinal powder into 75% ethanol 15 times the amount of the sargentgloryvine stem medicinal powder, performing ultrasonic extraction for 40min, and filtering to obtain filtrate a; adding 75% ethanol with 10 times of the total volume of the extract for the second time, performing ultrasonic extraction for 30min, and filtering to obtain filtrate b; mixing the two filtrates, and concentrating under reduced pressure to 0.5g/mL to obtain caulis Sargentodoxae extract;
(2) adding water with the temperature of 40 ℃ according to the formula proportion into a preparation container, and starting stirring;
(3) sequentially adding the sargentgloryvine stem extract obtained in the step (1), sodium chloride and propylene glycol, and continuously stirring for 10 min;
(4) sequentially adding glycerol, vitamin B6, and dextran sodium sulfate, and stirring for 20 min;
(5) sequentially adding flos Rosae Rugosae hydrosol and sodium carboxymethylcellulose, stirring for 10min, and stopping stirring.
Example 2
(1) Adding 25g of sargentgloryvine stem medicinal powder into 15 times of 50% ethanol, carrying out ultrasonic extraction for 40min, and filtering to obtain filtrate a; adding 10 times of 50% ethanol for the second time, performing ultrasonic extraction for 30min, and filtering to obtain filtrate b; mixing the two filtrates, and concentrating under reduced pressure to 0.3g/mL to obtain caulis Sargentodoxae extract;
(2) adding water with the temperature of 50 ℃ according to the formula proportion into a preparation container, and starting stirring;
(3) sequentially adding the sargentgloryvine stem extract obtained in the step (1), sodium chloride and propylene glycol, and continuously stirring for 20 min;
(4) sequentially adding glycerol, vitamin B6, and dextran sodium sulfate, and stirring for 30 min;
(5) sequentially adding flos Rosae Rugosae hydrosol and sodium carboxymethylcellulose, stirring for 20min, and stopping stirring. .
Example 3
The amounts are shown in Table 1, and the preparation method is the same as that of example 1.
Comparative example
The amounts are shown in Table 1, and the preparation method is the same as that of example 2.
TABLE 1
| Type of Material (wt%) | Example 1 | Example 2 | Example 3 | Comparative example |
| Caulis Sargentodoxae extract | 25 | 30 | 35 | / |
| Rose pure dew | 10 | 15 | 15 | 10 |
| Glycerol | 15 | 10 | 10 | 15 |
| Vitamin B6 | 5 | 4 | 3 | 5 |
| Propylene glycol | 3 | 2 | 2 | 3 |
| Sodium chloride | 3 | 2 | 2 | 3 |
| Sodium carboxymethylcellulose | 1 | 2 | 1 | 1 |
| Dextran sodium sulfate | 1 | 1 | 2 | 1 |
| Water (W) | To 100 of | To 100 of | To 100 of | To 100 of |
Whitening function test
First, experiment method
1. Method design
Volunteers were randomly selected and left and right faces were used as test areas, with the sample of example 2 (hereinafter, both referred to as experimental area) on one side and the sample of comparative example (hereinafter, both referred to as comparative area) on the other side. According to the test section, the test samples were used by the volunteers once a day in the morning and evening, and the application amount was according to the personal use habit (the volunteers were not allowed to use cosmetics similar to the test samples on their faces during the test period). The test period was 4 weeks total, during which the volunteers did not change the brand and usage habits of daily skin care products. Data acquisition, image acquisition, was performed on the test area before (week 0), after 1 week, 2 weeks and 4 weeks of product use. During the return visit, the dispensed test sample is reweighed. The fitness evaluation is performed by a dermatologist, the evaluation taking the form of clinical observations and interviews of volunteers, and the evaluation parameters include: redness, desquamation, itching, stinging, burning sensation, and others. Data and image acquisition were tested for the following indicators, respectively: skin whiteness L value, ITA DEG value skin melanin content MI value, skin moisture content MMV value.
2. Screening criteria
Selecting conditions are as follows: (1) volunteers who meet all the conditions listed below will be enrolled in the test for values of skin whiteness L and lightness ITA ° and skin melanin content MI. The number of cases is more than or equal to 25; age 18-55 years; sex randomization; the content of melanin in the skin on the inner side of the crank arm is 160-250; the whiteness L value of the skin on the inner side of the crank arm is between 55 and 65; in the last 1 month, no other product test is performed; those without severe systemic disease, immunodeficiency or autoimmune disease; those with inactive allergic disease; the past has no history of allergy to skin care cosmetics; in the last month, hormone drugs and immunosuppressants have not been used systemically; those who did not participate in other clinical trials; the person who voluntarily participates and can finish the specified contents according to the test requirements. (2) Volunteers meeting all of the following conditions will be enrolled in the test skin moisture content MMV values. Normal subjects of 20-65 years old have random gender and the number of the subjects is more than or equal to 20; those without severe systemic disease, immunodeficiency or autoimmune disease; those with inactive allergic disease; the past has no history of allergy to skin care cosmetics; in the last month, hormone drugs and immunosuppressants have not been used systemically; those who did not participate in other clinical trials; the person who voluntarily participates and can finish the specified contents according to the test requirements.
Exclusion criteria: pregnant or lactating women; outdoor work is the main, and sun exposure cannot be avoided; during the trial period, the hormone and immune preparation medicines are applied to the whole body; those who apply anti-inflammatory drugs during the trial period; the subject is not used as intended or the data is not complete.
3. Other requirements
The test sites did not use a cosmetic similar to the test samples for at least one week of the elution period, i.e., within one week prior to the test. Skin moisture content test sites were cheek (midline of eye and alar junction) and outside canthus. The other index testing part is the cheek (the junction of the midline of the eye and the nasal alar part)
4. Data processing
When the normal distribution is satisfied, the change of the data before and after the use of the sample and the difference between the test area and the matrix area are analyzed by using the t-test method. When the non-normal distribution is met, a rank sum test is applied.
Second, instrument and equipment
1. Instrument for measuring the position of a moving object
Skin color difference test probes and multifunctional skin test systems CL400 and MPA9 (CK company, germany); face image analysis system VISIA-CR (Canfield corporation, usa); skin black and red pigment tester MX18 (german CK company); skin moisture content tester CM825 (CK, germany).
2. Sample (I)
Example 1, comparative example
Third, experimental results
1. Skin whiteness
Table 2 results of skin whiteness before and after use (n ═ 32)
As can be seen from table 2, the skin whiteness L values tended to increase after the subjects used the example 1 group during the test period, and at weeks 2 and 4, the example 1 group data was significantly higher than the comparative group, and significantly higher than the whiteness immediately after the start of use.
2. Skin brightness
Table 3 results of skin brightness before and after use (n ═ 32)
As can be seen from table 3, the skin brightness of the subjects using the example 1 group showed a tendency to increase during the test period, although none of them was higher than the comparative example group, which may be related to the higher initial skin brightness of the comparative example group; however, at week 4, the skin brightness after use of example 1 was still significantly higher than immediately after use.
3. Melanin content of skin
Table 4 results of skin melanin content before and after use (n ═ 32)
As can be seen from table 4, the skin melanin content of the subjects showed a tendency to decrease after the test period using the group of example 1, wherein the skin melanin content was significantly different from that immediately after the start of the test period at week 4 using the group of example 1; in addition, the data for example 1 was significantly lower than the control at both weeks 2 and 4.
4. Moisture content of skin
Table 5 skin moisture content MMV results before and after use (n ═ 32)
As can be seen from table 5, the skin moisture content of the subjects showed a tendency to increase after the test period using the group of example 1, wherein the skin moisture content was significantly different from that immediately after the start of use at week 4 using the group of example 1; compared with the comparative example group, the example 1 group has no significant difference, but the increase of the skin moisture is slightly higher in the experimental period than the comparative example 1 group.
The foregoing descriptions of specific exemplary embodiments of the present invention have been presented for purposes of illustration and description. It is not intended to limit the invention to the precise form disclosed, and obviously many modifications and variations are possible in light of the above teaching. The exemplary embodiments were chosen and described in order to explain certain principles of the invention and its practical application to enable one skilled in the art to make and use various exemplary embodiments of the invention and various alternatives and modifications as are suited to the particular use contemplated. It is intended that the scope of the invention be defined by the claims and their equivalents.
Claims (9)
1. The composition with the effects of whitening skin and moisturizing is characterized by comprising 25-35 wt% of sargentgloryvine stem extract, 10-15 wt% of rose hydrosol, 10-15 wt% of glycerin, 78-5 wt% of vitamin B63, 2-3 wt% of propylene glycol, 2-3 wt% of sodium chloride, 1-2 wt% of sodium carboxymethylcellulose, 1-2 wt% of dextran sodium sulfate and 100 wt% of water.
2. The composition of claim 1, wherein the composition consists of sargentgloryvine stem extract 25 wt%, rose hydrosol 10 wt%, glycerin 15 wt%, vitamin B65 wt%, propylene glycol 3 wt%, sodium chloride 3 wt%, sodium carboxymethylcellulose 1 wt%, sodium dextran sulfate 1 wt%, and water supplemented to 100 wt%.
3. The composition of claim 1, wherein the composition consists of sargentgloryvine stem extract 30 wt%, rose hydrosol 15 wt%, glycerin 10 wt%, vitamin B64 wt%, propylene glycol 2 wt%, sodium chloride 2 wt%, sodium carboxymethylcellulose 2 wt%, sodium dextran sulfate 1 wt%, and water supplemented to 100 wt%.
4. The composition of claim 1, wherein the composition consists of sargentgloryvine stem extract 35 wt%, rose hydrosol 15 wt%, glycerin 10 wt%, vitamin B63 wt%, propylene glycol 2 wt%, sodium chloride 2 wt%, sodium carboxymethylcellulose 1 wt%, sodium dextran sulfate 2 wt%, and water supplemented to 100 wt%.
5. A method for preparing the composition with skin whitening and moisturizing effects as claimed in any one of claims 1 to 4, wherein the method comprises the following steps:
(1) adding 25-35 parts of sargentgloryvine stem medicinal powder into 10-15 times of 50-75% ethanol, performing ultrasonic extraction for 30-40 min, and filtering to obtain filtrate a; adding 10-15 times of 50-75% ethanol for the second time, performing ultrasonic extraction for 30-40 min, and filtering to obtain a filtrate b; combining the two filtrates, and concentrating under reduced pressure to 0.3-0.5 g/mL to obtain a sargentgloryvine stem extract;
(2) adding water with the temperature of 40-50 ℃ according to the formula proportion into a preparation container, and starting stirring.
(3) And (2) sequentially adding the sargentgloryvine stem extract obtained in the step (1), sodium chloride and propylene glycol, and continuously stirring for 10-20 min.
(4) Sequentially adding glycerol, vitamin B6 and dextran sodium sulfate, and continuously stirring for 20-30 min;
(5) sequentially adding rose hydrosol and sodium carboxymethylcellulose, continuously stirring for 10-20 min, and stopping stirring to obtain the rose beverage.
6. The method according to claim 5, characterized in that it comprises the steps of:
(1) adding 35 parts of sargentgloryvine stem medicinal powder into 75% ethanol 15 times the amount of the sargentgloryvine stem medicinal powder, performing ultrasonic extraction for 40min, and filtering to obtain filtrate a; adding 75% ethanol with 10 times of the total volume of the extract for the second time, performing ultrasonic extraction for 30min, and filtering to obtain filtrate b; mixing the two filtrates, and concentrating under reduced pressure to 0.5g/mL to obtain caulis Sargentodoxae extract;
(2) adding water with the temperature of 40 ℃ according to the formula proportion into a preparation container, and starting stirring;
(3) sequentially adding the sargentgloryvine stem extract obtained in the step (1), sodium chloride and propylene glycol, and continuously stirring for 10 min;
(4) sequentially adding glycerol, vitamin B6, and dextran sodium sulfate, and stirring for 20 min;
(5) sequentially adding flos Rosae Rugosae hydrosol and sodium carboxymethylcellulose, stirring for 10min, and stopping stirring.
7. The method according to claim 5, characterized in that it comprises the steps of:
(1) adding 25 parts of sargentgloryvine stem medicinal powder into 15 times of 50% ethanol, performing ultrasonic extraction for 40min, and filtering to obtain filtrate a; adding 10 times of 50% ethanol for the second time, performing ultrasonic extraction for 30min, and filtering to obtain filtrate b; mixing the two filtrates, and concentrating under reduced pressure to 0.3g/mL to obtain caulis Sargentodoxae extract;
(2) adding water with the temperature of 50 ℃ according to the formula proportion into a preparation container, and starting stirring;
(3) sequentially adding the sargentgloryvine stem extract obtained in the step (1), sodium chloride and propylene glycol, and continuously stirring for 20 min;
(4) sequentially adding glycerol, vitamin B6, and dextran sodium sulfate, and stirring for 30 min;
(5) sequentially adding flos Rosae Rugosae hydrosol and sodium carboxymethylcellulose, stirring for 20min, and stopping stirring.
8. A use method of a composition with skin whitening and moisturizing effects is characterized in that the method comprises the following steps: the composition is administered daily for at least 2 weeks.
9. Use according to claim 8, characterized in that the method is: the composition is administered daily for at least 4 weeks.
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| CN108434053A (en) * | 2018-05-24 | 2018-08-24 | 济南兰惠美业商贸有限公司 | A kind of Essence and preparation method thereof to lubricate the skin and muscle that has effects that compact |
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| CN108434053A (en) * | 2018-05-24 | 2018-08-24 | 济南兰惠美业商贸有限公司 | A kind of Essence and preparation method thereof to lubricate the skin and muscle that has effects that compact |
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Application publication date: 20201023 |