CN111801415A - 扩增淋巴细胞的方法 - Google Patents

扩增淋巴细胞的方法 Download PDF

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Publication number
CN111801415A
CN111801415A CN201880079423.3A CN201880079423A CN111801415A CN 111801415 A CN111801415 A CN 111801415A CN 201880079423 A CN201880079423 A CN 201880079423A CN 111801415 A CN111801415 A CN 111801415A
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cells
peptide
antigen
lymphocytes
tumor
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S·波比色
A·哈拉里
G·库克斯
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Ludwig Institute for Cancer Research Ltd
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • A61K40/4201Neoantigens
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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  • Peptides Or Proteins (AREA)
  • Developmental Biology & Embryology (AREA)
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CN201880079423.3A 2017-11-06 2018-11-06 扩增淋巴细胞的方法 Pending CN111801415A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762582163P 2017-11-06 2017-11-06
US62/582,163 2017-11-06
PCT/EP2018/080343 WO2019086711A1 (en) 2017-11-06 2018-11-06 Method for expansion of lymphocytes

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CN111801415A true CN111801415A (zh) 2020-10-20

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US (1) US20200338125A1 (https=)
EP (1) EP3707245A1 (https=)
JP (1) JP7357613B2 (https=)
CN (1) CN111801415A (https=)
AU (1) AU2018361561C1 (https=)
CA (1) CA3081479A1 (https=)
WO (1) WO2019086711A1 (https=)

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WO2021239083A1 (zh) * 2020-05-29 2021-12-02 上海君赛生物科技有限公司 肿瘤浸润淋巴细胞的种子细胞培养基及其应用
WO2022135525A1 (zh) * 2020-12-24 2022-06-30 苏州沙砾生物科技有限公司 肿瘤浸润淋巴细胞的制备方法及其用途
WO2022143785A1 (en) * 2020-12-31 2022-07-07 Shanghai Cellular Biopharmaceutical Group Ltd. Methods for preparing tumor-infiltrating lymphocytes
WO2022166947A1 (zh) * 2021-02-08 2022-08-11 苏州沙砾生物科技有限公司 肿瘤浸润淋巴细胞的制备方法及其用途
WO2023011433A1 (zh) * 2021-08-03 2023-02-09 苏州沙砾生物科技有限公司 一种修饰的肿瘤浸润淋巴细胞及其用途
WO2023164990A1 (zh) * 2022-03-03 2023-09-07 中山大学孙逸仙纪念医院深汕中心医院 一种自体肿瘤引流淋巴结淋巴细胞的制备方法及其应用
US12110506B2 (en) 2020-11-19 2024-10-08 Suzhou Grit Biotechnology Co., Ltd. Method for culturing tumor infiltrating lymphocytes
WO2025131119A1 (en) * 2023-12-22 2025-06-26 Everest Medicines (China) Co., Ltd. Cancer vaccines and uses thereof

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EP3877053A1 (en) 2018-11-05 2021-09-15 Ludwig Institute for Cancer Research Ltd Humanized and variant tgf-beta3 specific antibodies and methods and uses thereof
WO2020263919A1 (en) * 2019-06-24 2020-12-30 H. Lee Moffitt Cancer Center And Research Institute, Inc. A peptide-based screening method to identify neoantigens for use with tumor infiltrating lymphocytes
JP7337373B2 (ja) * 2019-07-29 2023-09-04 サイアス株式会社 抗原特異的t細胞の製造方法
MX2022007416A (es) * 2019-12-18 2022-09-19 Cbio As Proceso mejorado para el cultivo de linfocitos infiltrantes de tumor para uso terapeutico.
CA3158133A1 (en) 2020-04-28 2021-11-04 Lyell Immunopharma, Inc. Methods for culturing cells
AU2021320556A1 (en) 2020-08-07 2023-03-09 Neogene Therapeutics B.V. Methods to enrich genetically engineered T cells
WO2022040202A1 (en) * 2020-08-17 2022-02-24 Northwestern University B-cell based immunotherapy for the treatment of glioblastoma and other cancers
CN112501308B (zh) * 2020-11-30 2025-10-10 中国水产科学研究院珠江水产研究所 一组鳖科动物线粒体全基因组扩增通用引物
TW202242097A (zh) * 2021-01-20 2022-11-01 荷蘭商新基因治療公司 經工程化之抗原呈現細胞
JP2024517793A (ja) * 2021-04-30 2024-04-23 ティゲン・ファーマ・ソシエテ・アノニム 単一容器リンパ球拡大
US20240207319A1 (en) 2021-05-06 2024-06-27 Ludwig Institute For Cancer Research Ltd Compositions and methods for immunotherapy
US20240287456A1 (en) * 2021-06-22 2024-08-29 Achilles Therapeutics Uk Limited A method for producing antigen-specific t cells
EP4405464A4 (en) * 2021-09-21 2025-12-03 Univ Chicago METHODS AND COMPOSITION USING PATIENT-DERIVED AUTOLOGOUS NEOANTIGENS FOR CANCER TREATMENT
WO2024261339A1 (en) 2023-06-23 2024-12-26 Tigen Pharma Sa Lymphocyte-stimulatory matrix (lsm) and uses thereof for expansion of lymphocyte populations
WO2025081198A1 (en) * 2023-10-13 2025-04-17 Northwestern University B cell production and expansion

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Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021239083A1 (zh) * 2020-05-29 2021-12-02 上海君赛生物科技有限公司 肿瘤浸润淋巴细胞的种子细胞培养基及其应用
US12110506B2 (en) 2020-11-19 2024-10-08 Suzhou Grit Biotechnology Co., Ltd. Method for culturing tumor infiltrating lymphocytes
WO2022135525A1 (zh) * 2020-12-24 2022-06-30 苏州沙砾生物科技有限公司 肿瘤浸润淋巴细胞的制备方法及其用途
CN115175988A (zh) * 2020-12-24 2022-10-11 苏州沙砾生物科技有限公司 肿瘤浸润淋巴细胞的培养方法及其用途
CN115175988B (zh) * 2020-12-24 2024-06-14 苏州沙砾生物科技有限公司 肿瘤浸润淋巴细胞的制备方法及其用途
WO2022143785A1 (en) * 2020-12-31 2022-07-07 Shanghai Cellular Biopharmaceutical Group Ltd. Methods for preparing tumor-infiltrating lymphocytes
WO2022166947A1 (zh) * 2021-02-08 2022-08-11 苏州沙砾生物科技有限公司 肿瘤浸润淋巴细胞的制备方法及其用途
CN115315509A (zh) * 2021-02-08 2022-11-08 苏州沙砾生物科技有限公司 肿瘤浸润淋巴细胞的制备方法及其用途
CN115315509B (zh) * 2021-02-08 2024-05-07 苏州沙砾生物科技有限公司 肿瘤浸润淋巴细胞的制备方法及其用途
WO2023011433A1 (zh) * 2021-08-03 2023-02-09 苏州沙砾生物科技有限公司 一种修饰的肿瘤浸润淋巴细胞及其用途
WO2023164990A1 (zh) * 2022-03-03 2023-09-07 中山大学孙逸仙纪念医院深汕中心医院 一种自体肿瘤引流淋巴结淋巴细胞的制备方法及其应用
WO2025131119A1 (en) * 2023-12-22 2025-06-26 Everest Medicines (China) Co., Ltd. Cancer vaccines and uses thereof

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US20200338125A1 (en) 2020-10-29
CA3081479A1 (en) 2019-05-09
EP3707245A1 (en) 2020-09-16
WO2019086711A1 (en) 2019-05-09
AU2018361561C1 (en) 2025-07-03
AU2018361561B2 (en) 2025-01-30
JP2021501596A (ja) 2021-01-21
JP7357613B2 (ja) 2023-10-06
AU2018361561A1 (en) 2020-05-07

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