CN111801136A - 神经刺激装置 - Google Patents
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Abstract
本公开描述了一种包括内部支撑梳的可植入导线装置。支撑梳可以包括一个或多个面,其能够对准、布线和保持导线装置的内部导线。支撑梳可以使导线能够与包括引线装置的电极的微电极膜相互连接。
Description
相关申请的交叉引用
本申请要求在2018年3月2日提交的题为“神经刺激装置”的美国非临时专利申请No.15/910,278的优先权,该申请通过引用整体结合到本文中。
背景技术
深度脑刺激(DBS)可以包括神经刺激治疗,其涉及刺激人脑和身体的电刺激系统。DBS可用于治疗许多神经障碍。DBS可涉及电刺激大脑的目标区域。
发明内容
本公开描述了一种可以形成为圆柱形的刺激装置。内部地,刺激装置可以包括硅蚀刻的支撑梳,以对准、布线和保持电线。支撑梳可以使得电线与包括刺激装置的电极的微电极膜相互连接。刺激装置也可以包括内部支撑管,可以通过提供长边缘锚定系统来减少微电极膜从其环氧树脂模制件的机械移位。微电极膜可以卷绕成为三维构造,已增加在组装操作期间的自由度。
根据本公开的至少一个方面,可植入导线装置可以包括支撑梳。支撑梳可以包括附接面以及布线面。布线面可以包括多个槽。导线装置可以包括微电极膜。微电极膜可以包括主体。主体可以包括多个电极。微电极膜可以包括从主体延伸出的延伸部。延伸部可以包括第一面。延伸部的第一面可以包括与多个电极耦合的多个电触点。延伸部可以包括第二面。延伸部的第二面可以与支撑梳的附接面耦合。导线装置可以包括多个电线。多个电线中的每一个可以穿过多个槽中的相应一个槽并且与多个电触点中的相应一个电触点耦合。
附接面可以包括通道,以在微电极膜的第二面的至少一部分下方引导粘合剂。微电极膜的主体的第一面可以与支撑管耦合。支撑管可以包括与多个电极对准的多个不透射线的标记物。支撑管可以在第一端上包括多个城齿。第一端可以被配置为与支撑梳配合。
导线装置可以包括支撑管,支撑管可以包括多个不透射线的标记物。多个电线中的每个电线可以利用电线接合与多个电触点中的相应一个电触点耦合。
微电极膜的延伸部可以包括第一腿部和第二腿部。第一腿部可以包括延伸部的第一面和延伸部的第二面。第二腿部可以包括将多个电极的子集耦合到多个电触点的多个迹线。
延伸部的第一腿部和第二腿部可以围绕支撑梳卷绕。导线装置可以包括微电极膜的环氧树脂回填以形成探针轴。
根据本公开的至少一个方面,一种制造可植入导线装置的方法可以包括提供支撑梳。支撑梳可以包括附接面和布线面。布线面可以包括多个槽。该方法可以包括将微电极膜的第一部分与支撑梳的附接面耦合。微电极膜的第一部分可以包括多个电触点。该方法可以包括将多个电线中的每一个定位成穿过布线面的多个槽中的相应一个槽。该方法可以包括将多个电线中的每一个与多个电触点中的相应一个电触点耦合。该方法可以包括围绕支撑梳卷绕微电极膜的第二部分。
该方法可以包括形成微电极膜的第二部分。第二部分包括与多个电触点电连通的多个电极。该方法可以包括形成微电极膜的第三部分。第三部分可以包括将多个电极的一部分耦合到多个电触点的一部分的多条电迹线。
该方法可以包括将微电极膜的第二部分耦合到支撑管的外表面。微电极膜的第二部分可以包括多个电极。该方法可以包括用环氧树脂模制支撑梳。
该方法可以包括在支撑管中形成多个不透射线的标记物。该方法可以包括将多个不透射线的标记物与形成在微电极膜中的多个电极对准。多个不透射线的标记物可以从多个电极偏移。
该方法可以包括将多个电线中的每一个电线与多个电触点中的相应一个电触点进行电线接合。该方法可以包括卷绕微电极膜的第二部分以形成圆柱体。该方法可以包括用环氧树脂填充圆柱体。
该方法可以包括用环氧树脂对在附接面中形成的通道进行底部填充,以将微电极膜的第一部分与附接面耦合。该方法可以包括在硅中蚀刻出支撑梳。
该方法可以包括将微电极膜的第一边缘与微电极膜的第二边缘耦合以形成圆柱体。该方法可以包括将微电极膜的第一边缘和第二边缘插入支撑管的槽中。
附图说明
附图不是按比例绘制的。在各个附图中,相同的附图标记和名称表示相同的元件。为了清楚起见,不是每个部件都在每幅图中被标记。在附图中:
图1示出了执行神经刺激的示例系统。
图2示出了用于图1所示系统的刺激导线。
图3示出了图2所示的刺激导线的远端的透视图。
图4示出了用于图2所示的刺激导线的微电极膜的俯视图。
图5示出了处于卷绕构造的微电极膜。
图6示出了用于图2所示的刺激导线的示例支撑管。
图7示出了从支撑管的远端观察的与支撑管耦合的微电极膜。
图8-图10示出了用于图2所示的刺激导线的示例支撑梳。
图11-图14示出了图2所示的刺激导线的远端的视图。
图15示出了图2中所示的刺激导线中的支撑梳和微电极膜之间的界面的局部视图。
图16示出了可以用于图2所示的刺激导线的示例支撑梳的局部视图。
图17示出了支撑梳与支撑管的耦合的局部视图。
图18和图19示出了具有突出部的微电极膜的示例性配置。
图20示出了用于图1所示系统的示例性支撑管和标记物。
图21示出了用于图1所示系统中的具有圆形构造的示例性支撑梳。
图22示出了制造用在图1所示系统中的导线装置的示例方法。
具体实施方式
上文介绍并在下文更详细讨论的各种概念可以以多种方式中的任何方式来实现,因为所描述的概念不限于任何特定的实现方式。提供具体实现和应用的示例主要是出于说明性目的。
图1示出了用于执行神经刺激的示例系统50。系统50包括植入患者52的脑部54的刺激导线100。刺激导线100通过电缆56与刺激器58耦合。刺激器58产生治疗电刺激,该治疗电刺激可以通过刺激导线100传递到患者的脑部54。刺激导线100可以是可植入导线装置,其可以长期或短期地植入患者52体内。
图2示出了刺激导线100。刺激导线100包括远端110和近端112。远端110包括多个电极108。近端112包括多个端子触点116。每个端子触点116与至少一个电极108电耦合。例如,电线(或其它电迹线)可以从端子触点116中的一个穿过主体114的内部延伸到朝远端110设置的触点,该触点与电极108电连通。
图3示出了刺激导线100的远端110的透视图。作为概述,远端110包括具有多个电极108的微电极膜104。微电极膜104与支撑管132耦合。远端110还包括支撑梳102。支撑梳102可以使线106能够附接至微电极膜104。远端110还包括探头轴140。下面结合图4-图9等描述远端110的部件,并且结合图10-图17等进一步描述组装的远端110。
远端110包括微电极膜104。图4示出了微电极膜104的俯视图。图4示出了平面构造的微电极膜104。微电极膜104包括主体120和延伸部122。主体120包括多个电极108。延伸部122包括多个触点118。触点118可以经由迹线124与电极108耦合。
微电极膜104包括主体120。主体120可以包括多个电极108。主体120可包括约4个至约64个之间、约8个至约32个之间、约8个至约24个之间、或约4个至约12个之间的电极108。电极108可以被配置为定向或全向电极。例如,在全向配置中,电极108可基本上延伸主体120的高度126,使得当微电极膜104被形成为圆柱体时(如图5所示),电极108基本上围绕(例如,至少80%或至少90%)远端110的圆周缠绕。在定向配置中,如图4所示,电极108仅延伸微电极膜104的高度126的一部分。例如,在定向配置中,电极108可各自仅在主体120的高度126的约10%和约80%之间、约10%和约60%之间、约10%和约40%之间、或约10%和约25%之间延伸。电极108可以按列分组以跨越高度126。一个或多个定向配置的电极108可以电耦合在一起以形成全向电极108。通过连接微电极膜104内的两个迹线124或通过经由电线106连接终端触点116,可以电地发生至少两个定向配置的电极108之间的耦合以形成全向电极108。
微电极膜104可以包括多个迹线124。迹线124可以将电极108与一个或多个触点118耦合。微电极膜104可以包括相同数量的触点118和电极108,使得每个电极108与单个触点118耦合。微电极膜104可以包括比电极108更少的触点118,使得多于一个电极108与相同的触点118耦合(以形成例如全向电极)。每个迹线124可以与电极108形成一个或多个连接。例如,迹线124可以分支成两个或更多个外围迹线,外围迹线在围绕电极108的外围的若干点处与电极108耦合。与电极108中的每一个进行多个连接可以增加微电极膜104的可靠性。
延伸部122可以包括触点118。触点118可提供界面,在该界面处,电线106与微电极膜104耦合。例如,每个电线106可以与触点118中的相应一个触点进行电线接合或激光接合。
延伸部122可包括第一腿部128和第二腿部130。触点118可设置在第一腿部128的第一面上。第一腿部128还可包括朝向第一腿部128的每一端设置的开口158。开口158可以是穿过第一腿部128的孔。开口158可以与形成在支撑梳102的附接面中的入口对准(并且在下文中结合附图中的图8进一步描述)。第二腿部130可以包括从触点118延伸到电极108的迹线124的子集。与沿着单个腿部布线迹线124的系统相比,使迹线124的子集沿着第二腿部130延伸可以使得更大数量的迹线124(并且因此电极108)能够被并入微电极膜104中。
图5示出了卷绕构造的微电极膜104。如图所示,主体120的相对边缘朝向彼此卷绕以形成圆柱体。第二腿部130绕第一腿部128卷绕以形成圆柱体的第二部分。如图5和图6所示,主体120可以绕支撑管卷绕。
图6示出了示例性支撑管132。支撑管132可以包括多个标记物134。支撑管132可以包括槽136。支撑管132的近端可以包括多个城齿138。
支撑管132可包括不透辐射的金属(例如医用级不锈钢)、非金属材料(例如塑料)或其组合。支撑管132可以包括多个标记物134。标记物134可以是不透射线的。例如,当用CT扫描仪或X射线对刺激导线100成像时,标记物134是可见的。当支撑管132由不透辐射的金属制造时,标记物134可以是支撑管132的主体中的孔或空隙。标记物134可以穿过支撑管132的壁。当标记物134是穿过支撑管132的壁的孔时,与具有标记物134的支撑管132的部分相比,没有标记物134的区域可以是相对更不透射线的。电极108可以与标记物134对准。电极108可以与标记物134之间的区域对准。支撑管132可以用塑料材料制造,并且标记物134可以通过局部掺杂聚合物(例如硼轰击)或者通过用掺杂聚合物(例如硼掺杂塑料)回填而制成不透辐射的。
支撑管132可以包括多个城齿138。城齿138可以是从支承管132的一端延伸的多个延伸部。每个城齿138可以与相邻城齿138分开间隙或垛口。城齿138中的每一个的长度可以是大约在大约0.2mm和大约2mm之间、大约0.4mm和大约1.5mm之间、大约0.2mm和大约1mm之间、或大约0.4mm和大约0.6mm之间。城齿138可具有约0.1mm至约2mm、约0.1mm和约1.5mm之间、约0.1mm和约1mm之间、约0.1mm和约0.5mm之间、或约0.2mm和约4mm之间的周向节距。
城齿138被构造为与支撑梳102配合。城齿138被构造成与刺激导线100的探针轴配合。探针轴可以通过环氧树脂过模制工艺形成。城齿138可提供凹槽和凸脊,环氧树脂可流入其中并结合以形成探针轴。
支撑管132可以包括槽136。槽136可以在支撑管132的长度上延伸。槽136可穿过支撑管132的壁,或者可在支撑管132的外表面中形成通道。
图7示出了从支撑管132的远端观察时与支撑管132耦合的微电极膜104。包括电极108的主体120的第一面可以面向外并且远离支撑管132。微电极膜的主体120的第二面与支撑管132的外表面耦合以形成圆柱体。主体120的相对边缘插入穿过槽136。
图8示出了支撑梳102的附接面和支撑梳102的第一布线面144。附接面142包括通道148。支撑梳102的附接面142被配置为与微电极膜104的面耦合。通道148被配置为在微电极膜104的与附接面142耦合的面的一部分下方引导粘合剂。通道148可以在约5μm和约40μm之间、在约10μm和约30μm之间、或在约10μm和约20μm之间。在刺激导线100的制造期间,微电极膜104的面可以通过机械装置(例如夹具)与支撑梳102的附接面142耦合。入口150可延伸超过微电极膜104的与附接面142耦合的部分。可以将粘合剂添加到入口150。毛细管作用可沿着通道148的长度并在微电极膜104的与附接面142耦合的面下方输送粘合剂。一旦粘合剂固化,就可释放用于将微电极膜104保持在附接面142上的机械装置。
支撑梳102可以包括第一布线面144。第一布线面144可以包括多个槽152(其也可以被称为通道152)。第一布线面144可以包括用于每个电线106的槽152。在制造过程中,每个触点118可以基本上与槽152中的一个对齐,以便于将电线106与触点118耦合。例如,每根电线106可穿过相应的槽152以与不同的触点118对齐。槽152的间距可以与触点118的间距相匹配。
图9示出了支撑梳102的第二布线面154。第二布线面154与附接面142相对。第二布线面154可以包括多个指状物156。指状物156是凸起的突出部,其可以在第二布线面154中形成通道157。每个通道157可终止于通向第一布线面144上的槽152的孔159中。
图10示出了第二布线面154,其中电线106沿第二布线面154穿过。电线106可以进入由指状物156限定的通道157。从通道157起,电线106可以穿过通道157的端部处的孔159,并且进入第一布线面144上的相应槽152中的一个槽中。电线106的颜色编码可以使得能够实现电线106从端子触点116中的每一个到远端110的对应电极108的适当布线。
图11-图14示出了远端110的不同视图。图11-图14中所示的每个视图示出了相对于先前的图旋转90度的刺激导线100的远端110的视图。例如,图11可以说是示出了远端110的顶视图,图12可以说是示出了远端110的第一侧视图,图13可以说是示出了远端110的底视图,并且图14可以说是示出了远端110的第二侧视图。前面的“顶部”、“第一侧”、“第二侧”和“底部”被提供仅用于参考,因为远端110的任何面都可以用作“顶部”、“底部”等。例如,电极108围绕远端110的圆周的放置使得远端110的任何面(或角度)能够用作远端110的顶部、底部或侧面。
一起参考图11-图14,其中,远端110包括微电极膜104。微电极膜104包括多个电极108。电极108经由电线106与端子触点116耦合。远端110还包括支撑梳102。支撑梳102可以便于在远端110的轴内管理电线106。支撑梳102还可将电线106的终止端固定或保持在微电极膜104的触点附近。将电线106的终止端定位在微电极膜104的触点附近可以实现制造中的改进的效率,因为支撑梳102可以提供电线106和微电极膜104的触点118之间的对准。
图15示出了支撑梳102和微电极膜104之间的界面的放大图。图15示出了卷绕的或圆柱形构造的微电极膜104。微电极膜104的延伸部122围绕支撑梳102卷绕,使得支撑梳102位于由卷绕的(或圆柱形)微电极膜104限定的腔内。第二腿部130围绕支撑梳102缠绕并且朝向支撑梳的第二布线面154(在图15中被图示为支撑梳102的背面)定位。第一腿部128可与附接面142耦合。
微电极膜104的第一腿部128可以与附接面142耦合。第一腿部128可以包括第一面和与第一面相对的第二面,第一面包括触点118,第二面可以与支撑梳102耦合。第二面可以与附接面142耦合。第一腿部128可以定位在附接面142上,使得开口158基本上与入口150对齐。例如,在围绕支撑梳102卷绕延伸部122之前,粘合剂可以通过第一腿部128中的开口158被输送到入口150。通过毛细管作用,粘合剂可以流过通道148并且在第一腿部128下方流动以将第一腿部128(例如,第一腿部128的第二面)与附接面142耦合。
通过将第一腿部128与附接面142连接,触点118可基本上与槽152对准。触点118可从槽152偏移。例如,每个触点118可以定位在相邻的槽152之间。槽152可以实现电线管理,并且将电线106定位在正确的位置以与触点118接合。例如,电线106可穿过每个槽152以与触点118中的一个触点对准。电线106可以与触点118耦合。电线106可以与触点118电线接合或焊接。
图16示出了支撑梳102的放大视图。图16基本上示出了图15中支撑梳102的背面(和远端110)。
如所示出的,微电极膜104的第二腿部130围绕支撑梳102卷绕。电线106沿着支撑梳102的第二布线面154通过。每个电线106穿过由指状物156形成的通道。电线106可以穿过形成在通道157的端部处的孔159并且进入槽152中。指状物156(和由此形成的通道)可以使得能够沿着支撑梳102并到槽152来布线电线106,在该槽处电线106可以与触点118耦合。
图17示出了支撑梳102与支撑管132的耦合的放大视图。支撑梳102的第一端可以包括被配置成装配在支撑管132的一部分内的钮或其它结构。城齿138可以在支撑梳102的第一端处围绕该钮。探针轴140可通过环氧树脂包覆成型工艺形成。环氧树脂可以流入城齿138之间的区域中,以形成与支撑管132耦合的探针轴140。探头轴140的环氧树脂可以将支撑梳102和第二腿部130包封在刺激导线的远端110的主体内。探针轴140可由注射成型或微加工工艺形成。
图18和图19示出了微电极膜104的示例性构造和用于将微电极膜104形成为圆柱体的方法。图19示出了处于部分卷绕状态的微电极膜104的主体120部分。主体120的第一边缘可以包括多个突出部160。相对边缘(或朝向相对边缘)可包括多个槽162。主体120可包括用于每个突出部160的槽162。突出部160可以是渐细的,随着突出部160从主体120延伸出而变窄。例如,突出部160可以成形为类似箭头的头部。每个突出部160可以滑入相应的一个槽162中。突出部160可包括倒钩,一旦突出部160插入槽162中并越过倒钩,倒钩就将突出部160锁定到槽162中。图19示出了具有完全插入到槽162中以形成圆柱体的突出部160的主体120。
图20示出了示例性支撑管132和标记物134。图20所示的示例性支撑管132可以由非磁性或非不透辐射的材料制成。标记物134可以由不透辐射的材料制成。支撑管132可以包括多个凹槽164。凹槽164可以成形为接收标记物134。标记物134可以用粘合剂、夹子或压力配合法固定到凹槽164中。当微电极膜104与支撑管132耦合时,电极108可以与标记物134对准。
图21示出了圆形构造的示例支撑梳102。支撑梳102可以包括围绕支撑梳102的外周的多个槽152。微电极膜104的延伸部分可以是盘形的,并且可以包括朝向延伸部分的外周分布的多个触点118。电线106可以穿过每个槽152并朝向触点118。槽152可以使电线106与触点118对准。电线106可以被电线接合或焊接到触点118。
图22示出了制造导线装置的示例方法200。方法200可包括提供支撑梳(块202)。方法200可包括定位多个电线(块204)。方法200可包括将支撑梳与微电极膜耦合(块206)。方法200可包括将电线与微电极膜耦合(块208)。方法200可包括卷绕微电极膜(块210)。
如上所述,方法200可以包括提供支撑梳(块202)。还参考图1-图21,支撑梳102可以包括附接面142和第一布线面144。第一布线面144可以包括多个槽152。微电极膜104可以包括第二布线面154。第二布线面154可以包括在第二布线面154上形成通道的多个指状物156。通道157可终止于孔159中,该孔将第二布线面154的通道157与第一布线面144的槽152连接。附接面142可以包括通道148。
支撑梳102可以通过注射成型工艺、微机械加工工艺、光刻工艺或3D打印工艺制造。支撑梳102可以由硅、塑料、金属、液晶聚合物(LCP)或其它材料制成。不透射线的材料可以被包括在支撑梳102中,以使远端110在X射线期间能够被看到。例如,在注射成型工艺中使用的聚合物可以掺杂有不透辐射的材料,例如硫酸钡(BaSO4)、硼,或者可以将金属环、带或部件结合到支撑梳102中。
方法200可包括定位电线(块204)。参见图10,其中,电线106可展开并沿第二布线面154延伸。第二布线面154可以布置电线106。第二布线面154可包括可限定通道157的多个指状物156。电线106可穿过相应的通道157并穿过在通道157端部处的孔159,该孔将通道157与槽152耦合。每根电线106可以穿过相应的一个槽152。槽152可以保持和定位电线106。例如,槽152可将每根电线106保持为固定地接近相应的触点118。
方法200可包括将支撑梳102与微电极膜104耦合(块206)。微电极膜104可以包括不同的部分。例如,微电极膜104可包括主体120和延伸部122。主体120可以包括多个电极108。延伸部122可以包括多个腿部。一个腿部可以包括多个触点118。延伸部分122和主体120都可以包括多个迹线124。
微电极膜104可以包括绝缘层和导电层的堆叠。微电极膜可以是薄膜、微机电系统(MEMS)电极膜。导电层可以包括迹线124、触点118和电极108。不同的导电层可以通过绝缘层彼此隔离。绝缘层也可以将导电层(或其部分)与外部环境隔离。微电极膜104可以使用增材制造工艺被制造为平面膜。
通过将微电极膜104的第一部分与附接面142耦合,微电极膜104可以与支撑梳102耦合。例如,延伸部122的一部分可与附接面142耦合。延伸部分122的第一腿部128可以包括多个触点118,其可以与附接面142耦合。与具有触点118的面相对的面可以与附接面142耦合,使得触点118背离支撑梳102。
当微电极膜104与支撑梳102耦合时,延伸部122的开口158可以与支撑梳102的入口150对准。通过将粘合剂施加到入口150,微电极膜104可以与支撑梳102耦合。毛细力可将粘合剂从入口150驱动并通过通道148,以填充微电极膜104和由通道148形成的支撑梳102之间的空间。一旦被固化了,粘合剂可以将微电极膜104与支撑梳102耦合。
方法200可包括将电线与微电极膜耦合(块208)。此外,参照图15,其中,电线106可穿过第二布线面154上的相应通道并进入相应槽152中。槽152可以将每根电线106定位在触点118之一附近。电线106可以利用电线接合、焊接或激光接合与触点118耦合。
方法200可包括卷绕微电极膜(块210)。微电极膜104的延伸部122可以围绕支撑梳102卷绕。微电极膜104的主体120可以围绕支撑梳102卷绕。围绕支撑梳102卷绕延伸部122可以将延伸部122的第二腿部130放置在支撑梳102的第二布线面154附近。
微电极膜104的主体120可围绕支撑管132卷绕。微电极膜104可以与支撑管132的外表面耦合。支撑管132可以包括槽136。主体120的相对边缘可以插入到槽136中。
一旦微电极膜104被卷绕,微电极膜104和支撑梳102可被放置在模具中。模具可以用环氧树脂填充。环氧树脂包覆成型可以形成探头轴140。探头轴140可以包住延伸部122、支撑梳102和导线106的至少一部分。探针轴140可以流入城齿138中并与支撑管132耦合。
尽管在附图中以特定顺序描绘了操作,但是这样的操作不需要以所示的特定顺序或以顺序执行,并且不需要执行所有示出的操作。可以以不同的顺序执行这里描述的动作。
各种系统组件的分离不需要在所有实现方式中分离,并且所描述的程序组件可以被包括在单个硬件或软件产品中。
现在已经描述了一些说明性的实现方式,很明显,前述内容是说明性的而非限制性的,已经通过示例的方式呈现。特别地,尽管本文呈现的许多示例涉及方法动作或系统元素的特定组合,但是那些动作和那些元素可以以其他方式组合以实现相同的目的。结合一个实施方式讨论的动作、元件和特征不旨在被排除在其他实施方式或实施方式中的类似角色之外。
这里使用的措辞和术语是为了描述的目的,而不应被认为是限制。在此使用的“包括”、“包含”、“具有”、“含有”、“涉及”、“特征在于”及其变化,意味着包括其后列出的项目、其等价物和附加项目,以及由其后列出的项目专门组成的替代实施方式。在一个实施方式中,本文描述的系统和方法由所有描述的元件、动作或部件中的一个、多于一个的每个组合或所有描述的元件、动作或部件组成。
如本文所用,术语“约”和“基本上”将被本领域普通技术人员理解,并且将根据其所使用的上下文而在一定程度上变化。如果在使用该术语的上下文中,本领域普通技术人员不清楚该术语的使用,“约”将意味着高达特定术语的正负10%。
对本文以单数形式提及的系统和方法的实现方式或元件或动作的任何引用也可以涵盖包括多个这些元件的实现方式,并且对本文的任何实现方式或元件或动作的任何复数引用也可以涵盖仅包括单个元件的实现方式。单数或复数形式的引用不旨在将本公开的系统或方法、其组件、动作或元件限制为单个或复数配置。对基于任何信息、动作或元素的任何动作或元素的引用可以包括其中动作或元素至少部分地基于任何信息、动作或元素的实现方式。
本文公开的任何实施方式可以与任何其他实施方式或实施例组合,并且对“实施方式”、“一些实施方式”、“一个实施方式”等的引用不一定是相互排斥的,并且旨在指示结合实施方式描述的特定特征、结构或特性可以被包括在至少一个实施方式或实施例中。这里使用的这些术语不一定全部指相同的实现方式。任何实施方式可以以与本文公开的方面和实施方式一致的任何方式与任何其他实施方式包括地或排他地组合。
除非明确地相反指示,否则如本说明书和权利要求书中所使用的不定冠词“一”和“一个”应理解为意指“至少一个”。
对“或”的引用可以被解释为包括性的,使得使用“或”描述的任何术语可以指示所有所描述的术语中的单个、多于一个、以及任何一个。例如,对“‘A’和‘B’中的至少一个“的引用可以仅包括“A”、仅包括“B”、以及包括“A”和“B”。结合“包括”或其它开放术语使用的这些引用可包括附加项目。
在附图、详细描述或任何权利要求中的技术特征之后跟随有附图标记的情况下,包括附图标记以增加附图、详细描述和权利要求的可理解性。因此,参考标记或它们的不存在对任何权利要求要素的范围都没有任何限制作用。
在不脱离本发明的特征的情况下,本文所述的系统和方法可以以其它特定形式来实施。前述实现方式是说明性的,而不是对所描述的系统和方法的限制。因此,本文所述的系统和方法的范围由所附权利要求而不是前述说明书来指示,并且在权利要求的等同方案的含义和范围内的变化被包含在其中。
Claims (20)
1.一种可植入导线装置,包括:
支撑梳,包括:
附接面;以及
包括多个槽的布线面;
微电极膜,包括具有多个电极的主体和延伸部,所述延伸部包括:
第一面,所述延伸部的第一面具有与所述多个电极耦合的多个电触点;以及
第二面,所述延伸部的第二面与所述支撑梳的附接面耦合;以及
多个电线,所述多个电线中的每一个穿过所述多个槽中的相应一个槽并且与所述多个电触点中的相应一个电触点耦合。
2.根据权利要求1所述的导线,其中所述附接面包括通道,以在所述微电极膜的第二面的至少一部分下方引导粘合剂。
3.根据权利要求1所述的导线,包括:
支撑管;以及
所述微电极膜的主体的与所述支撑管耦合的面。
4.根据权利要求3所述的导线,其中,所述支撑管包括与所述多个电极对准的多个不透射线的标记物。
5.根据权利要求3所述的导线,其中所述支撑管在第一端上包括多个城齿,所述第一端被配置为与所述支撑梳配合。
6.根据权利要求1所述的导线,包括:
支撑管,包括多个不透射线的标记物。
7.根据权利要求1所述的导线,其中所述多个电线中的每个电线利用电线接合与所述多个电触点中的相应一个电触点耦合。
8.根据权利要求1所述的导线,其中所述微电极膜的延伸部包括:
第一腿部,包括所述延伸部的第一面和所述延伸部的第二面;以及
第二腿部,包括将所述多个电极的子集耦合到所述多个电触点的多个迹线。
9.根据权利要求1所述的导线,其中所述微电极膜的延伸部包括:
围绕支撑梳卷绕的第一腿部和第二腿部。
10.根据权利要求1所述的导线,包括:
回填微电极膜的环氧树脂。
11.一种方法,包括:
提供支撑梳,所述支撑梳包括:
附接面;以及
包括多个槽的布线面;
将微电极膜的第一部分与所述支撑梳的附接面耦合,所述微电极膜的第一部分包括多个电触点;
将多个电线中的每一个定位成穿过所述布线面的多个槽中的相应一个槽;
将所述多个电线中的每一个与所述多个电触点中的相应一个电触点耦合;以及
围绕所述支撑梳卷绕所述微电极膜的第二部分。
12.根据权利要求11所述的方法,包括:
形成所述微电极膜的第二部分,所述第二部分包括与所述多个电触点电连通的多个电极;以及
形成所述微电极膜的第三部分,所述第三部分包括将所述多个电极的一部分耦合到所述多个电触点的一部分的多条电迹线。
13.根据权利要求11所述的方法,包括:
将所述微电极膜的第二部分耦合到支撑管的外表面,所述微电极膜的第二部分包括多个电极;以及
用环氧树脂填充所述支撑管。
14.根据权利要求11所述的方法,包括:
在支撑管中形成多个不透射线的标记物;以及
将所述多个不透射线的标记物与形成在所述微电极膜中的多个电极对准。
15.根据权利要求11所述的方法,包括:
将所述多个电线中的每一个电线与所述多个电触点中的相应一个电触点进行电线接合。
16.根据权利要求11所述的方法,包括:
卷绕所述微电极膜的第二部分以形成圆柱体;以及
用环氧树脂填充所述圆柱体。
17.根据权利要求11所述的方法,包括:
用环氧树脂对在所述附接面中形成的通道进行底部填充,以将所述微电极膜的第一部分与所述附接面耦合。
18.根据权利要求11所述的方法,包括:
在硅中蚀刻出支撑梳。
19.根据权利要求11所述的方法,包括:
将所述微电极膜的第一边缘与所述微电极膜的第二边缘耦合以形成圆柱体。
20.根据权利要求11所述的方法,包括:
将微电极膜与支撑管耦合;以及
将所述微电极膜的第一边缘和第二边缘插入所述支撑管的槽中。
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Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5125150A (en) * | 1991-09-03 | 1992-06-30 | Amp Incorporated | Tool for mass terminating wires to electrical connectors |
CN101970041A (zh) * | 2007-11-16 | 2011-02-09 | 耳蜗有限公司 | 电极阵列以及形成电极阵列的方法 |
US20110047795A1 (en) * | 2009-09-01 | 2011-03-03 | Kevin Turner | Medical leads with segmented electrodes and methods of fabrication thereof |
US20110301665A1 (en) * | 2008-11-12 | 2011-12-08 | Ecole Polytechnique Federale De Lausanne | Microfabricated neurostimulation device |
US20130261489A1 (en) * | 2012-03-29 | 2013-10-03 | Ad-Tech Medical Instrument Corp. | Intracranial sensing & monitoring device with macro and micro electrodes |
CN103415317A (zh) * | 2011-02-17 | 2013-11-27 | 先进仿生学股份公司 | 线构造 |
US20160059004A1 (en) * | 2014-08-27 | 2016-03-03 | Aleva Neurotherapeutics | Deep brain stimulation lead |
US20160059016A1 (en) * | 2014-08-27 | 2016-03-03 | Aleva Neurotherapeutics | Leadless neurostimulator |
US20170312494A1 (en) * | 2016-04-28 | 2017-11-02 | Medtronic, Inc. | Lead implant fixation mechanism |
Family Cites Families (720)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1065969A (fr) | 1977-09-28 | 1979-11-06 | Gratien Bouillon | Sonde cerebrale auto-bloquante |
US4550733A (en) | 1984-01-09 | 1985-11-05 | Pain Suppression Labs, Inc. | Electronic dental analgesia apparatus and methodology |
US4837049A (en) | 1986-06-17 | 1989-06-06 | Alfred E. Mann Foundation For Scientific Research | Method of making an electrode array |
US4969468A (en) | 1986-06-17 | 1990-11-13 | Alfred E. Mann Foundation For Scientific Research | Electrode array for use in connection with a living body and method of manufacture |
JPH07114768B2 (ja) | 1987-04-22 | 1995-12-13 | 松下電器産業株式会社 | X線診断装置 |
US4917093A (en) | 1987-06-12 | 1990-04-17 | Minnesota Mining And Manufacturing Company | Biological tissue stimulator with adjustable high voltage power supply dependent upon load impedance |
US4989617A (en) | 1989-07-14 | 1991-02-05 | Case Western Reserve University | Intramuscular electrode for neuromuscular stimulation system |
US5215088A (en) | 1989-11-07 | 1993-06-01 | The University Of Utah | Three-dimensional electrode device |
US5095905A (en) | 1990-06-07 | 1992-03-17 | Medtronic, Inc. | Implantable neural electrode |
US5345936A (en) | 1991-02-15 | 1994-09-13 | Cardiac Pathways Corporation | Apparatus with basket assembly for endocardial mapping |
US5524338A (en) | 1991-10-22 | 1996-06-11 | Pi Medical Corporation | Method of making implantable microelectrode |
US5237996A (en) | 1992-02-11 | 1993-08-24 | Waldman Lewis K | Endocardial electrical mapping catheter |
US5282840A (en) | 1992-03-26 | 1994-02-01 | Medtronic, Inc. | Multiple frequency impedance measurement system |
GB9207731D0 (en) | 1992-04-07 | 1992-05-27 | Proteus Molecular Design | Improvements in or relating to vaccines |
US6832996B2 (en) | 1995-06-07 | 2004-12-21 | Arthrocare Corporation | Electrosurgical systems and methods for treating tissue |
US5400784A (en) | 1993-10-15 | 1995-03-28 | Case Western Reserve University | Slowly penetrating inter-fascicular nerve cuff electrode and method of using |
US5921924A (en) | 1993-12-03 | 1999-07-13 | Avitall; Boaz | Mapping and ablation catheter system utilizing multiple control elements |
US5501703A (en) | 1994-01-24 | 1996-03-26 | Medtronic, Inc. | Multichannel apparatus for epidural spinal cord stimulator |
US5496369A (en) | 1994-02-09 | 1996-03-05 | University Of Iowa Research Foundation | Human cerebral cortex neural prosthetic |
US5800535A (en) | 1994-02-09 | 1998-09-01 | The University Of Iowa Research Foundation | Wireless prosthetic electrode for the brain |
US7077822B1 (en) | 1994-02-09 | 2006-07-18 | The University Of Iowa Research Foundation | Stereotactic hypothalamic obesity probe |
US6129685A (en) | 1994-02-09 | 2000-10-10 | The University Of Iowa Research Foundation | Stereotactic hypothalamic obesity probe |
EP0743839A4 (en) | 1994-02-09 | 1999-02-10 | Univ Iowa Res Found | HUMAN GROUND BRAIN CORNEAL PROSTHESIS |
US5697975A (en) | 1994-02-09 | 1997-12-16 | The University Of Iowa Research Foundation | Human cerebral cortex neural prosthetic for tinnitus |
US5458629A (en) | 1994-02-18 | 1995-10-17 | Medtronic, Inc. | Implantable lead ring electrode and method of making |
US6216043B1 (en) | 1994-03-04 | 2001-04-10 | Ep Technologies, Inc. | Asymmetric multiple electrode support structures |
DE4408108A1 (de) | 1994-03-10 | 1995-09-14 | Bavaria Med Tech | Katheter zur Injektion eines Fluid bzw. eines Arneimittelns |
US5391250A (en) | 1994-03-15 | 1995-02-21 | Minimed Inc. | Method of fabricating thin film sensors |
US5824029A (en) | 1994-04-28 | 1998-10-20 | Medtronic, Inc. | Implantable medical system for performing transthoracic impedance measurements associated with cardiac function |
US5697651A (en) | 1995-03-02 | 1997-12-16 | Senior Flexonics, Inc. | Flexible duct joint having a low leakage, pressure-balanced bellows seal |
US5927277A (en) | 1995-04-28 | 1999-07-27 | Medtronic, Inc. | Method and apparatus for securing probes within a burr hole |
US20020169485A1 (en) | 1995-10-16 | 2002-11-14 | Neuropace, Inc. | Differential neurostimulation therapy driven by physiological context |
US5727552A (en) | 1996-01-11 | 1998-03-17 | Medtronic, Inc. | Catheter and electrical lead location system |
US5833714A (en) | 1996-01-18 | 1998-11-10 | Loeb; Gerald E. | Cochlear electrode array employing tantalum metal |
US5755759A (en) | 1996-03-14 | 1998-05-26 | Eic Laboratories, Inc. | Biomedical device with a protective overlayer |
US6505078B1 (en) | 1996-04-04 | 2003-01-07 | Medtronic, Inc. | Technique for adjusting the locus of excitation of electrically excitable tissue |
JP2000508201A (ja) | 1996-04-04 | 2000-07-04 | メドトロニック・インコーポレーテッド | 生体組織刺激及び記録技術 |
US5702429A (en) | 1996-04-04 | 1997-12-30 | Medtronic, Inc. | Neural stimulation techniques with feedback |
US5713922A (en) | 1996-04-25 | 1998-02-03 | Medtronic, Inc. | Techniques for adjusting the locus of excitation of neural tissue in the spinal cord or brain |
US5628317A (en) | 1996-04-04 | 1997-05-13 | Medtronic, Inc. | Ultrasonic techniques for neurostimulator control |
US5716377A (en) | 1996-04-25 | 1998-02-10 | Medtronic, Inc. | Method of treating movement disorders by brain stimulation |
US5683422A (en) | 1996-04-25 | 1997-11-04 | Medtronic, Inc. | Method and apparatus for treating neurodegenerative disorders by electrical brain stimulation |
US6094598A (en) | 1996-04-25 | 2000-07-25 | Medtronics, Inc. | Method of treating movement disorders by brain stimulation and drug infusion |
US7269457B2 (en) | 1996-04-30 | 2007-09-11 | Medtronic, Inc. | Method and system for vagal nerve stimulation with multi-site cardiac pacing |
US6449507B1 (en) | 1996-04-30 | 2002-09-10 | Medtronic, Inc. | Method and system for nerve stimulation prior to and during a medical procedure |
US6006134A (en) | 1998-04-30 | 1999-12-21 | Medtronic, Inc. | Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers |
US5713923A (en) | 1996-05-13 | 1998-02-03 | Medtronic, Inc. | Techniques for treating epilepsy by brain stimulation and drug infusion |
US5782798A (en) | 1996-06-26 | 1998-07-21 | Medtronic, Inc. | Techniques for treating eating disorders by brain stimulation and drug infusion |
US6121351A (en) | 1996-09-03 | 2000-09-19 | Eastman Chemical Company | Thermoplastic compositions containing anthraquinone polysulfonamide colorants |
US5797970A (en) | 1996-09-04 | 1998-08-25 | Medtronic, Inc. | System, adaptor and method to provide medical electrical stimulation |
US5843148A (en) | 1996-09-27 | 1998-12-01 | Medtronic, Inc. | High resolution brain stimulation lead and method of use |
US5752979A (en) | 1996-11-01 | 1998-05-19 | Medtronic, Inc. | Method of controlling epilepsy by brain stimulation |
US5800474A (en) | 1996-11-01 | 1998-09-01 | Medtronic, Inc. | Method of controlling epilepsy by brain stimulation |
US5957958A (en) | 1997-01-15 | 1999-09-28 | Advanced Bionics Corporation | Implantable electrode arrays |
JP2002511850A (ja) | 1997-04-29 | 2002-04-16 | ケネス ブルーム,インコーポレイテッド | 報酬欠損症候群の対立遺伝子多遺伝子診断および処置 |
US5893883A (en) | 1997-04-30 | 1999-04-13 | Medtronic, Inc. | Portable stimulation screening device for screening therapeutic effect of electrical stimulation on a patient user during normal activities of the patient user |
US5975085A (en) | 1997-05-01 | 1999-11-02 | Medtronic, Inc. | Method of treating schizophrenia by brain stimulation and drug infusion |
US6128537A (en) | 1997-05-01 | 2000-10-03 | Medtronic, Inc | Techniques for treating anxiety by brain stimulation and drug infusion |
US6050992A (en) | 1997-05-19 | 2000-04-18 | Radiotherapeutics Corporation | Apparatus and method for treating tissue with multiple electrodes |
US5991668A (en) | 1997-09-25 | 1999-11-23 | Medtronic, Inc. | Medical electrical lead |
US6581046B1 (en) | 1997-10-10 | 2003-06-17 | Yeda Research And Development Co. Ltd. | Neuronal phase-locked loops |
US5941906A (en) | 1997-10-15 | 1999-08-24 | Medtronic, Inc. | Implantable, modular tissue stimulator |
US6647296B2 (en) | 1997-10-27 | 2003-11-11 | Neuropace, Inc. | Implantable apparatus for treating neurological disorders |
US6459936B2 (en) | 1997-10-27 | 2002-10-01 | Neuropace, Inc. | Methods for responsively treating neurological disorders |
US6011996A (en) | 1998-01-20 | 2000-01-04 | Medtronic, Inc | Dual electrode lead and method for brain target localization in functional stereotactic brain surgery |
US7520890B2 (en) | 1998-01-26 | 2009-04-21 | Phillips Peter W | Reinforced graft and method of deployment |
US6415187B1 (en) | 1998-02-10 | 2002-07-02 | Advanced Bionics Corporation | Implantable, expandable, multicontact electrodes and insertion needle for use therewith |
US6205361B1 (en) | 1998-02-10 | 2001-03-20 | Advanced Bionics Corporation | Implantable expandable multicontact electrodes |
US6227203B1 (en) | 1998-02-12 | 2001-05-08 | Medtronic, Inc. | Techniques for controlling abnormal involuntary movements by brain stimulation and drug infusion |
US6330466B1 (en) | 1998-02-23 | 2001-12-11 | California Institute Of Technology | Using a multi-electrode probe in creating an electrophysiological profile during stereotactic neurosurgery |
US6024095A (en) | 1998-04-10 | 2000-02-15 | Proteus Therapeutics, Inc. | Corneal heat and stretch method and apparatus |
US6161047A (en) | 1998-04-30 | 2000-12-12 | Medtronic Inc. | Apparatus and method for expanding a stimulation lead body in situ |
US6421566B1 (en) | 1998-04-30 | 2002-07-16 | Medtronic, Inc. | Selective dorsal column stimulation in SCS, using conditioning pulses |
US6374140B1 (en) | 1998-04-30 | 2002-04-16 | Medtronic, Inc. | Method and apparatus for treating seizure disorders by stimulating the olfactory senses |
US6319241B1 (en) | 1998-04-30 | 2001-11-20 | Medtronic, Inc. | Techniques for positioning therapy delivery elements within a spinal cord or a brain |
US6018682A (en) | 1998-04-30 | 2000-01-25 | Medtronic, Inc. | Implantable seizure warning system |
US6522930B1 (en) | 1998-05-06 | 2003-02-18 | Atrionix, Inc. | Irrigated ablation device assembly |
US6104960A (en) | 1998-07-13 | 2000-08-15 | Medtronic, Inc. | System and method for providing medical electrical stimulation to a portion of the nervous system |
US9320900B2 (en) | 1998-08-05 | 2016-04-26 | Cyberonics, Inc. | Methods and systems for determining subject-specific parameters for a neuromodulation therapy |
US8762065B2 (en) | 1998-08-05 | 2014-06-24 | Cyberonics, Inc. | Closed-loop feedback-driven neuromodulation |
US7599736B2 (en) | 2001-07-23 | 2009-10-06 | Dilorenzo Biomedical, Llc | Method and apparatus for neuromodulation and physiologic modulation for the treatment of metabolic and neuropsychiatric disease |
US7231254B2 (en) | 1998-08-05 | 2007-06-12 | Bioneuronics Corporation | Closed-loop feedback-driven neuromodulation |
US7403820B2 (en) | 1998-08-05 | 2008-07-22 | Neurovista Corporation | Closed-loop feedback-driven neuromodulation |
US6366813B1 (en) | 1998-08-05 | 2002-04-02 | Dilorenzo Daniel J. | Apparatus and method for closed-loop intracranical stimulation for optimal control of neurological disease |
US7242984B2 (en) | 1998-08-05 | 2007-07-10 | Neurovista Corporation | Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease |
US7209787B2 (en) | 1998-08-05 | 2007-04-24 | Bioneuronics Corporation | Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease |
US6125300A (en) | 1998-09-11 | 2000-09-26 | Medtronic, Inc. | Implantable device with output circuitry for simultaneous stimulation at multiple sites |
US6033403A (en) | 1998-10-08 | 2000-03-07 | Irvine Biomedical, Inc. | Long electrode catheter system and methods thereof |
US6205359B1 (en) | 1998-10-26 | 2001-03-20 | Birinder Bob Boveja | Apparatus and method for adjunct (add-on) therapy of partial complex epilepsy, generalized epilepsy and involuntary movement disorders utilizing an external stimulator |
US6253109B1 (en) | 1998-11-05 | 2001-06-26 | Medtronic Inc. | System for optimized brain stimulation |
DE60042155D1 (de) | 1999-03-24 | 2009-06-18 | Second Sight Medical Prod Inc | Retinale farbprothese zur wiederherstellung des farbsehens |
US6253110B1 (en) | 1999-04-27 | 2001-06-26 | Medtronic Inc | Method for tissue stimulation and fabrication of low polarization implantable stimulation electrode |
US6356784B1 (en) | 1999-04-30 | 2002-03-12 | Medtronic, Inc. | Method of treating movement disorders by electrical stimulation and/or drug infusion of the pendunulopontine nucleus |
US6109269A (en) | 1999-04-30 | 2000-08-29 | Medtronic, Inc. | Method of treating addiction by brain infusion |
US6353762B1 (en) | 1999-04-30 | 2002-03-05 | Medtronic, Inc. | Techniques for selective activation of neurons in the brain, spinal cord parenchyma or peripheral nerve |
US7650291B2 (en) | 1999-06-23 | 2010-01-19 | Koninklijke Philips Electronics N.V. | Video visitation system and method for a health care location |
US6343226B1 (en) | 1999-06-25 | 2002-01-29 | Neurokinetic Aps | Multifunction electrode for neural tissue stimulation |
EP1062973B1 (en) | 1999-06-25 | 2005-01-19 | NeuroKinetic ApS | A multifunction electrode for neural tissue stimulation |
US7047082B1 (en) | 1999-09-16 | 2006-05-16 | Micronet Medical, Inc. | Neurostimulating lead |
US6560486B1 (en) | 1999-10-12 | 2003-05-06 | Ivan Osorio | Bi-directional cerebral interface system |
US6882881B1 (en) | 1999-10-19 | 2005-04-19 | The Johns Hopkins University | Techniques using heat flow management, stimulation, and signal analysis to treat medical disorders |
US6295476B1 (en) | 1999-11-01 | 2001-09-25 | Medtronic, Inc. | Medical lead conductor fracture visualization method and apparatus |
US6375666B1 (en) | 1999-12-09 | 2002-04-23 | Hans Alois Mische | Methods and devices for treatment of neurological disorders |
US6549812B1 (en) | 1999-11-29 | 2003-04-15 | Medtronic, Inc. | Medical electrical lead having bending stiffness which increase in the distal direction |
US6556873B1 (en) | 1999-11-29 | 2003-04-29 | Medtronic, Inc. | Medical electrical lead having variable bending stiffness |
US6692450B1 (en) | 2000-01-19 | 2004-02-17 | Medtronic Xomed, Inc. | Focused ultrasound ablation devices having selectively actuatable ultrasound emitting elements and methods of using the same |
US6356787B1 (en) | 2000-02-24 | 2002-03-12 | Electro Core Techniques, Llc | Method of treating facial blushing by electrical stimulation of the sympathetic nerve chain |
US6434431B1 (en) | 2000-01-20 | 2002-08-13 | Medtronic, Inc. | Intramuscular medical electrical lead with fixation member |
US6301492B1 (en) | 2000-01-20 | 2001-10-09 | Electrocore Technologies, Llc | Device for performing microelectrode recordings through the central channel of a deep-brain stimulation electrode |
US6356786B1 (en) | 2000-01-20 | 2002-03-12 | Electrocore Techniques, Llc | Method of treating palmar hyperhydrosis by electrical stimulation of the sympathetic nervous chain |
US6587733B1 (en) | 2000-02-08 | 2003-07-01 | Medtronic, Inc. | Percutaneous surgical lead body with directed stimulation |
US6493590B1 (en) | 2000-02-09 | 2002-12-10 | Micronet Medical, Inc. | Flexible band electrodes for medical leads |
US6920359B2 (en) | 2000-02-15 | 2005-07-19 | Advanced Bionics Corporation | Deep brain stimulation system for the treatment of Parkinson's Disease or other disorders |
US6708064B2 (en) | 2000-02-24 | 2004-03-16 | Ali R. Rezai | Modulation of the brain to affect psychiatric disorders |
WO2001072201A2 (en) | 2000-03-29 | 2001-10-04 | Arizona Board Of Regents | Device for creating a neural interface and method for making same |
US7497844B2 (en) | 2000-03-31 | 2009-03-03 | Medtronic, Inc. | System and method for positioning implantable medical devices within coronary veins |
US6853858B2 (en) | 2000-05-08 | 2005-02-08 | Brainsgate, Ltd. | Administration of anti-inflammatory drugs into the central nervous system |
US7289852B2 (en) | 2000-06-16 | 2007-10-30 | Medtronic. Inc. | Implantable medical device configured for diagnostic emulation through serial communication |
US6687538B1 (en) | 2000-06-19 | 2004-02-03 | Medtronic, Inc. | Trial neuro stimulator with lead diagnostics |
US20030125786A1 (en) | 2000-07-13 | 2003-07-03 | Gliner Bradford Evan | Methods and apparatus for effectuating a lasting change in a neural-function of a patient |
US7010351B2 (en) | 2000-07-13 | 2006-03-07 | Northstar Neuroscience, Inc. | Methods and apparatus for effectuating a lasting change in a neural-function of a patient |
US7672730B2 (en) | 2001-03-08 | 2010-03-02 | Advanced Neuromodulation Systems, Inc. | Methods and apparatus for effectuating a lasting change in a neural-function of a patient |
US6510347B2 (en) | 2000-08-17 | 2003-01-21 | William N. Borkan | Spinal cord stimulation leads |
US6487446B1 (en) | 2000-09-26 | 2002-11-26 | Medtronic, Inc. | Method and system for spinal cord stimulation prior to and during a medical procedure |
US6871098B2 (en) | 2000-10-30 | 2005-03-22 | Medtronic, Inc. | Method for treating obsessive-compulsive disorder with electrical stimulation of the brain internal capsule |
US6804552B2 (en) | 2000-11-03 | 2004-10-12 | Medtronic, Inc. | MEMs switching circuit and method for an implantable medical device |
US6757970B1 (en) | 2000-11-07 | 2004-07-06 | Advanced Bionics Corporation | Method of making multi-contact electrode array |
US6591128B1 (en) | 2000-11-09 | 2003-07-08 | Koninklijke Philips Electronics, N.V. | MRI RF coil systems having detachable, relocatable, and or interchangeable sections and MRI imaging systems and methods employing the same |
US6529774B1 (en) | 2000-11-09 | 2003-03-04 | Neuropace, Inc. | Extradural leads, neurostimulator assemblies, and processes of using them for somatosensory and brain stimulation |
US6818396B1 (en) | 2000-11-28 | 2004-11-16 | Proteus S.A. | Process for determination of the activity of a substance using an in vitro functional test |
US20020072739A1 (en) | 2000-12-07 | 2002-06-13 | Roberta Lee | Methods and devices for radiofrequency electrosurgery |
EP1341579B1 (en) | 2000-12-07 | 2006-11-29 | Medtronic, Inc. | Directional brain stimulation and recording leads |
US6594524B2 (en) | 2000-12-12 | 2003-07-15 | The Trustees Of The University Of Pennsylvania | Adaptive method and apparatus for forecasting and controlling neurological disturbances under a multi-level control |
EP1381407A2 (en) | 2000-12-29 | 2004-01-21 | Medtronic, Inc. | Non-conformance monitoring and control techniques for an implantable medical device |
US7177701B1 (en) | 2000-12-29 | 2007-02-13 | Advanced Bionics Corporation | System for permanent electrode placement utilizing microelectrode recording methods |
US7628780B2 (en) | 2001-01-13 | 2009-12-08 | Medtronic, Inc. | Devices and methods for interstitial injection of biologic agents into tissue |
US7493172B2 (en) | 2001-01-30 | 2009-02-17 | Boston Scientific Neuromodulation Corp. | Methods and systems for stimulating a nerve originating in an upper cervical spine area to treat a medical condition |
US6788975B1 (en) | 2001-01-30 | 2004-09-07 | Advanced Bionics Corporation | Fully implantable miniature neurostimulator for stimulation as a therapy for epilepsy |
US7149586B2 (en) | 2002-03-28 | 2006-12-12 | Second Sight Medical Products, Inc. | Variable pitch electrode array |
US6597953B2 (en) | 2001-02-20 | 2003-07-22 | Neuropace, Inc. | Furcated sensing and stimulation lead |
US6829509B1 (en) | 2001-02-20 | 2004-12-07 | Biophan Technologies, Inc. | Electromagnetic interference immune tissue invasive system |
GB0104982D0 (en) | 2001-02-28 | 2001-04-18 | Gill Steven | Electrode |
US6538443B2 (en) | 2001-03-20 | 2003-03-25 | Koninklijke Philips Electronics N.V. | MRI gradient coil with variable field of view and apparatus and methods employing the same |
WO2002078592A2 (en) | 2001-03-30 | 2002-10-10 | Case Western Reserve University | Systems and methods for selectively stimulating components in, on, or near the pudendal nerve or its branches to achieve selective physiologic responses |
US7010343B2 (en) | 2001-04-06 | 2006-03-07 | Mattioli Engineering Ltd. | Method and apparatus for skin absorption enhancement and transdermal drug delivery |
US6909920B2 (en) | 2001-04-27 | 2005-06-21 | Medtronic, Inc. | System and method for positioning an implantable medical device within a body |
AU2002255248A1 (en) | 2001-04-27 | 2002-11-11 | Alexander Grinshpoon | Diagnosis, treatment and research of mental disorders |
AU2002305357A1 (en) | 2001-05-01 | 2002-11-11 | Second Sight, Llc | High-density array of micro-machined electrodes for neural stimulation |
US6928320B2 (en) | 2001-05-17 | 2005-08-09 | Medtronic, Inc. | Apparatus for blocking activation of tissue or conduction of action potentials while other tissue is being therapeutically activated |
EP1401513A4 (en) | 2001-05-30 | 2007-09-12 | Innersea Technology | IMPLANTABLE DEVICES WITH A LIQUID CRYSTAL POLYMER SUBSTRATE |
US6479999B1 (en) | 2001-06-05 | 2002-11-12 | Koninklijke Philips Electronics N.V. | Efficiently shielded MRI gradient coil with discretely or continuously variable field of view |
US6560472B2 (en) | 2001-06-21 | 2003-05-06 | Microhelix, Inc. | Multi-channel structurally robust brain probe and method of making the same |
US20090069706A1 (en) | 2001-06-21 | 2009-03-12 | Jerome Boogaard | Brain probe adapted to be introduced through a canula |
US6671544B2 (en) | 2001-06-28 | 2003-12-30 | Medtronic, Inc. | Low impedance implantable extension for a neurological electrical stimulator |
US6622047B2 (en) | 2001-07-28 | 2003-09-16 | Cyberonics, Inc. | Treatment of neuropsychiatric disorders by near-diaphragmatic nerve stimulation |
US6622038B2 (en) | 2001-07-28 | 2003-09-16 | Cyberonics, Inc. | Treatment of movement disorders by near-diaphragmatic nerve stimulation |
US6600956B2 (en) * | 2001-08-21 | 2003-07-29 | Cyberonics, Inc. | Circumneural electrode assembly |
US20060241717A1 (en) | 2001-08-30 | 2006-10-26 | Whitehurst Todd K | Treatment of movement disorders by extra dural motor cortex stimulation |
US6999819B2 (en) | 2001-08-31 | 2006-02-14 | Medtronic, Inc. | Implantable medical electrical stimulation lead fixation method and apparatus |
DE10143268A1 (de) | 2001-09-04 | 2003-03-20 | Heptec Gmbh | Neurostimulator, Steuergerät dafür sowie Datenübertragungsverfahren |
WO2003026738A1 (en) | 2001-09-28 | 2003-04-03 | Northstar Neuroscience, Inc. | Methods and apparatus for electrically stimulating cells implanted in the nervous system |
IL145700A0 (en) | 2001-09-30 | 2002-06-30 | Younis Imad | Electrode system for neural applications |
AUPR851601A0 (en) | 2001-10-26 | 2001-11-29 | Cochlear Limited | Auditory midbrain implant |
US6944497B2 (en) | 2001-10-31 | 2005-09-13 | Medtronic, Inc. | System and method of treating stuttering by neuromodulation |
US7010356B2 (en) | 2001-10-31 | 2006-03-07 | London Health Sciences Centre Research Inc. | Multichannel electrode and methods of using same |
US7187978B2 (en) | 2001-11-01 | 2007-03-06 | Medtronic, Inc. | Method and apparatus for programming an implantable medical device |
US6745079B2 (en) | 2001-11-07 | 2004-06-01 | Medtronic, Inc. | Electrical tissue stimulation apparatus and method |
US7286878B2 (en) | 2001-11-09 | 2007-10-23 | Medtronic, Inc. | Multiplexed electrode array extension |
US7061240B2 (en) | 2001-11-26 | 2006-06-13 | Koninklijke Philips Electronics N.V. | Magnetic resonance imaging method with reduced acoustic noise |
US7546166B2 (en) | 2001-11-29 | 2009-06-09 | Medtronic, Inc. | Medical lead designs for lead placement through tissue |
US7050856B2 (en) | 2002-01-11 | 2006-05-23 | Medtronic, Inc. | Variation of neural-stimulation parameters |
US6970747B2 (en) | 2002-01-11 | 2005-11-29 | Kokones Scott B | Neurostimulation lead stylet handle |
US6904306B1 (en) | 2002-01-23 | 2005-06-07 | Koninklijke Philips Electronics N.V. | Method and apparatus for evaluation of contrast agent uptake based on derived parametric images |
WO2003066153A2 (en) | 2002-02-01 | 2003-08-14 | The Cleveland Clinic Foundation | Neural stimulation delivery device with independently moveable delivery structures |
EP1480721A4 (en) | 2002-02-04 | 2007-09-12 | Great Lakes Biosciences Llc | TREATMENT OF NEUROLOGICAL ILLNESSES WITH ELECTRICAL STIMULATION |
US7063767B1 (en) | 2002-02-08 | 2006-06-20 | Proteus Technical Solutions, Inc. | Process for creating a durable EMI/RFI shield between two or more structural surfaces and shield formed therefrom |
US6875205B2 (en) | 2002-02-08 | 2005-04-05 | Alaris Medical Systems, Inc. | Vial adapter having a needle-free valve for use with vial closures of different sizes |
US7317948B1 (en) | 2002-02-12 | 2008-01-08 | Boston Scientific Scimed, Inc. | Neural stimulation system providing auto adjustment of stimulus output as a function of sensed impedance |
US6978171B2 (en) | 2002-03-15 | 2005-12-20 | Medtronic, Inc. | Automated impedance measurement of an implantable medical device |
US7526341B2 (en) | 2002-03-15 | 2009-04-28 | Medtronic, Inc. | Amplitude ramping of waveforms generated by an implantable medical device |
US7236822B2 (en) | 2002-03-22 | 2007-06-26 | Leptos Biomedical, Inc. | Wireless electric modulation of sympathetic nervous system |
US7146222B2 (en) | 2002-04-15 | 2006-12-05 | Neurospace, Inc. | Reinforced sensing and stimulation leads and use in detection systems |
US7697995B2 (en) | 2002-04-25 | 2010-04-13 | Medtronic, Inc. | Surgical lead paddle |
US7076292B2 (en) | 2002-04-25 | 2006-07-11 | Medtronic, Inc. | Optical communication of neurostimulation-system information |
US6937891B2 (en) | 2002-04-26 | 2005-08-30 | Medtronic, Inc. | Independent therapy programs in an implantable medical device |
US7483748B2 (en) | 2002-04-26 | 2009-01-27 | Medtronic, Inc. | Programmable waveform pulses for an implantable medical device |
US7024246B2 (en) | 2002-04-26 | 2006-04-04 | Medtronic, Inc | Automatic waveform output adjustment for an implantable medical device |
US6950706B2 (en) | 2002-04-26 | 2005-09-27 | Medtronic, Inc. | Wave shaping for an implantable medical device |
US7295880B2 (en) | 2002-04-29 | 2007-11-13 | Medtronic, Inc. | Stimulation control for brain stimulation |
US6978178B2 (en) | 2002-04-30 | 2005-12-20 | Medtronic, Inc. | Method and apparatus for selecting an optimal electrode configuration of a medical electrical lead having a multiple electrode array |
AU2003224374A1 (en) | 2002-05-13 | 2003-11-11 | Koninklijke Philips Electronics N.V. | Reduction of susceptibility artifacts in subencoded single-shot magnetic resonance imaging |
US7151961B1 (en) | 2002-05-24 | 2006-12-19 | Advanced Bionics Corporation | Treatment of movement disorders by brain stimulation |
US7203548B2 (en) | 2002-06-20 | 2007-04-10 | Advanced Bionics Corporation | Cavernous nerve stimulation via unidirectional propagation of action potentials |
US20040015205A1 (en) | 2002-06-20 | 2004-01-22 | Whitehurst Todd K. | Implantable microstimulators with programmable multielectrode configuration and uses thereof |
US7860570B2 (en) | 2002-06-20 | 2010-12-28 | Boston Scientific Neuromodulation Corporation | Implantable microstimulators and methods for unidirectional propagation of action potentials |
US7181288B1 (en) | 2002-06-24 | 2007-02-20 | The Cleveland Clinic Foundation | Neuromodulation device and method of using the same |
US7006859B1 (en) | 2002-07-20 | 2006-02-28 | Flint Hills Scientific, L.L.C. | Unitized electrode with three-dimensional multi-site, multi-modal capabilities for detection and control of brain state changes |
US7254449B2 (en) | 2002-07-31 | 2007-08-07 | Advanced Bionics Corp | Systems and methods for providing power to one or more implantable devices |
WO2004036804A2 (en) | 2002-08-27 | 2004-04-29 | University Of Florida | Optimization of multi-dimensional time series processing for seizure warning and prediction |
US7328069B2 (en) | 2002-09-06 | 2008-02-05 | Medtronic, Inc. | Method, system and device for treating disorders of the pelvic floor by electrical stimulation of and the delivery of drugs to the left and right pudendal nerves |
US7369894B2 (en) | 2002-09-06 | 2008-05-06 | Medtronic, Inc. | Method, system and device for treating disorders of the pelvic floor by electrical stimulation of the sacral and/or pudendal nerves |
US7427280B2 (en) | 2002-09-06 | 2008-09-23 | Medtronic, Inc. | Method, system and device for treating disorders of the pelvic floor by delivering drugs to various nerves or tissues |
US7328068B2 (en) | 2003-03-31 | 2008-02-05 | Medtronic, Inc. | Method, system and device for treating disorders of the pelvic floor by means of electrical stimulation of the pudendal and associated nerves, and the optional delivery of drugs in association therewith |
US7204833B1 (en) | 2002-10-11 | 2007-04-17 | Flint Hills Scientific Llc | Multi-modal system for detection and control of changes in brain state |
AU2003301370A1 (en) | 2002-10-15 | 2004-05-04 | Medtronic Inc. | Multi-modal operation of a medical device system |
US7079977B2 (en) | 2002-10-15 | 2006-07-18 | Medtronic, Inc. | Synchronization and calibration of clocks for a medical device and calibrated clock |
US7280867B2 (en) | 2002-10-15 | 2007-10-09 | Medtronic, Inc. | Clustering of recorded patient neurological activity to determine length of a neurological event |
US20050010261A1 (en) | 2002-10-21 | 2005-01-13 | The Cleveland Clinic Foundation | Application of stimulus to white matter to induce a desired physiological response |
US7212851B2 (en) | 2002-10-24 | 2007-05-01 | Brown University Research Foundation | Microstructured arrays for cortex interaction and related methods of manufacture and use |
US7216000B2 (en) | 2002-10-31 | 2007-05-08 | Medtronic, Inc. | Neurostimulation therapy manipulation |
US7146219B2 (en) | 2002-10-31 | 2006-12-05 | Medtronic, Inc. | Applying filter information to identify combinations of electrodes |
WO2004043536A1 (en) | 2002-11-12 | 2004-05-27 | Neuropace, Inc. | System for adaptive brain stimulation |
US7035690B2 (en) | 2002-11-15 | 2006-04-25 | Medtronic, Inc. | Human-implantable-neurostimulator user interface having multiple levels of abstraction |
US7599730B2 (en) | 2002-11-19 | 2009-10-06 | Medtronic Navigation, Inc. | Navigation system for cardiac therapies |
US7697972B2 (en) | 2002-11-19 | 2010-04-13 | Medtronic Navigation, Inc. | Navigation system for cardiac therapies |
US7047084B2 (en) | 2002-11-20 | 2006-05-16 | Advanced Neuromodulation Systems, Inc. | Apparatus for directionally stimulating nerve tissue |
AU2003294454A1 (en) | 2002-11-22 | 2004-06-18 | International Rehabilitative Sciences, Inc. | Surface stimulation for tremor control |
US7302298B2 (en) | 2002-11-27 | 2007-11-27 | Northstar Neuroscience, Inc | Methods and systems employing intracranial electrodes for neurostimulation and/or electroencephalography |
US7596415B2 (en) | 2002-12-06 | 2009-09-29 | Medtronic, Inc. | Medical devices incorporating carbon nanotube material and methods of fabricating same |
AU2003294596A1 (en) | 2002-12-09 | 2004-06-30 | Medtronic, Inc. | Lead connection module of a modular implantable medical device |
US7596408B2 (en) | 2002-12-09 | 2009-09-29 | Medtronic, Inc. | Implantable medical device with anti-infection agent |
WO2004052182A2 (en) | 2002-12-11 | 2004-06-24 | Proteus Biomedical, Inc. | Monitoring and treating hemodynamic parameters |
DE60324194D1 (de) | 2002-12-23 | 2008-11-27 | Medtronic Inc | Katheter mit mehreren infusionsabschnitten und zugehörige methoden |
US7216001B2 (en) | 2003-01-22 | 2007-05-08 | Medtronic Xomed, Inc. | Apparatus for intraoperative neural monitoring |
US7204798B2 (en) | 2003-01-24 | 2007-04-17 | Proteus Biomedical, Inc. | Methods and systems for measuring cardiac parameters |
JP4557964B2 (ja) | 2003-01-24 | 2010-10-06 | プロテウス バイオメディカル インコーポレイテッド | 心臓ペーシングを改善するための方法および装置 |
WO2004071737A2 (en) | 2003-02-04 | 2004-08-26 | Arizona Board Of Regents, Acting For And On Behalf Of Arizona State University (Abr/Asu) | Using benzocyclobutene as a biocompatible material |
US7328057B2 (en) | 2003-02-06 | 2008-02-05 | Medtronic, Inc. | Shunt passer or like surgical instrument configured for receiving different-sized positioning locators of image-guided surgical system |
WO2004080343A2 (en) | 2003-03-10 | 2004-09-23 | The Regents Of The University Of Michigan | Compositions and methods for use of alginate dural sealants |
US7647116B2 (en) | 2003-03-13 | 2010-01-12 | Medtronic, Inc. | Context-sensitive collection of neurostimulation therapy data |
US7548786B2 (en) | 2003-04-02 | 2009-06-16 | Medtronic, Inc. | Library for management of neurostimulation therapy programs |
US7489970B2 (en) | 2003-04-02 | 2009-02-10 | Medtronic, Inc. | Management of neurostimulation therapy using parameter sets |
US7505815B2 (en) | 2003-04-02 | 2009-03-17 | Medtronic, Inc. | Neurostimulation therapy usage diagnostics |
US7369893B2 (en) | 2004-12-01 | 2008-05-06 | Medtronic, Inc. | Method and apparatus for identifying lead-related conditions using prediction and detection criteria |
US7319899B2 (en) | 2003-04-23 | 2008-01-15 | Medtronic, Inc. | Sensing techniques for implantable medical devices |
US7369891B2 (en) | 2003-04-23 | 2008-05-06 | Medtronic, Inc. | Rate control techniques for implantable pulse generator systems |
US7343206B2 (en) | 2003-04-25 | 2008-03-11 | Medtronic, Inc. | Implantable medical lead and system, and method of use thereof |
US7463928B2 (en) | 2003-04-25 | 2008-12-09 | Medtronic, Inc. | Identifying combinations of electrodes for neurostimulation therapy |
US20040225335A1 (en) | 2003-05-08 | 2004-11-11 | Whitehurst Todd K. | Treatment of Huntington's disease by brain stimulation |
US7191016B2 (en) | 2003-05-15 | 2007-03-13 | Medtronic, Inc. | Medical system including a novel bipolar pacing and sensing pair |
US7317947B2 (en) | 2003-05-16 | 2008-01-08 | Medtronic, Inc. | Headset recharger for cranially implantable medical devices |
US7620454B2 (en) | 2003-05-19 | 2009-11-17 | Medtronic, Inc. | Gastro-electric stimulation for reducing the acidity of gastric secretions or reducing the amounts thereof |
US7107104B2 (en) | 2003-05-30 | 2006-09-12 | Medtronic, Inc. | Implantable cortical neural lead and method |
US7818048B2 (en) | 2003-06-02 | 2010-10-19 | Biosense Webster, Inc. | Catheter and method for mapping a pulmonary vein |
US7082336B2 (en) | 2003-06-04 | 2006-07-25 | Synecor, Llc | Implantable intravascular device for defibrillation and/or pacing |
CA2432810A1 (en) | 2003-06-19 | 2004-12-19 | Andres M. Lozano | Method of treating depression, mood disorders and anxiety disorders by brian infusion |
US7133718B2 (en) | 2003-06-19 | 2006-11-07 | Medtronic, Inc. | Method and apparatus for temporarily varying a parameter in an implantable medical device |
US7671594B2 (en) | 2003-06-24 | 2010-03-02 | Medtronic, Inc. | Magnetic resonance imaging interference immune device |
US7388378B2 (en) | 2003-06-24 | 2008-06-17 | Medtronic, Inc. | Magnetic resonance imaging interference immune device |
IL156816A0 (en) | 2003-07-07 | 2004-02-08 | Brainsgate Ltd | Stimulation arena |
US7647111B2 (en) | 2003-07-31 | 2010-01-12 | Medtronic, Inc. | Connector assembly for connecting a lead and an implantable medical device |
US7684866B2 (en) | 2003-08-01 | 2010-03-23 | Advanced Neuromodulation Systems, Inc. | Apparatus and methods for applying neural stimulation to a patient |
US20050033136A1 (en) | 2003-08-01 | 2005-02-10 | Assaf Govari | Catheter with electrode strip |
US20050038489A1 (en) | 2003-08-14 | 2005-02-17 | Grill Warren M. | Electrode array for use in medical stimulation and methods thereof |
US7263405B2 (en) | 2003-08-27 | 2007-08-28 | Neuro And Cardiac Technologies Llc | System and method for providing electrical pulses to the vagus nerve(s) to provide therapy for obesity, eating disorders, neurological and neuropsychiatric disorders with a stimulator, comprising bi-directional communication and network capabilities |
US7313430B2 (en) | 2003-08-28 | 2007-12-25 | Medtronic Navigation, Inc. | Method and apparatus for performing stereotactic surgery |
US7617002B2 (en) | 2003-09-15 | 2009-11-10 | Medtronic, Inc. | Selection of neurostimulator parameter configurations using decision trees |
US7252090B2 (en) | 2003-09-15 | 2007-08-07 | Medtronic, Inc. | Selection of neurostimulator parameter configurations using neural network |
US20050070972A1 (en) | 2003-09-26 | 2005-03-31 | Wahlstrand Carl D. | Energy shunt for producing an MRI-safe implantable medical device |
US7660620B2 (en) | 2003-09-29 | 2010-02-09 | Medtronic, Inc. | Timing techniques for magnetic resonance imaging |
US7623930B2 (en) | 2003-09-30 | 2009-11-24 | Medtronic, Inc. | Controlling telemetry during magnetic resonance imaging |
US7418292B2 (en) | 2003-10-01 | 2008-08-26 | Medtronic, Inc. | Device and method for attenuating an immune response |
US7206632B2 (en) | 2003-10-02 | 2007-04-17 | Medtronic, Inc. | Patient sensory response evaluation for neuromodulation efficacy rating |
US7561921B2 (en) | 2003-10-02 | 2009-07-14 | Medtronic, Inc. | Neurostimulator programmer with internal antenna |
US7356369B2 (en) | 2003-10-02 | 2008-04-08 | Medtronic, Inc. | Z-axis assembly of medical device programmer |
US7286882B2 (en) | 2003-10-03 | 2007-10-23 | Medtronic, Inc. | Implantable electrical connector system |
US8190248B2 (en) | 2003-10-16 | 2012-05-29 | Louisiana Tech University Foundation, Inc. | Medical devices for the detection, prevention and/or treatment of neurological disorders, and methods related thereto |
US20050171558A1 (en) | 2003-10-17 | 2005-08-04 | Abovitz Rony A. | Neurosurgery targeting and delivery system for brain structures |
EP1684861B1 (en) | 2003-10-21 | 2014-12-03 | The Regents Of The University Of Michigan | Intracranial neural interface system |
US7282050B2 (en) | 2003-10-31 | 2007-10-16 | Medtronic, Inc. | Ablation of exterior of stomach to treat obesity |
EP1694403A2 (en) | 2003-11-20 | 2006-08-30 | Advanced Neuromodulation Systems, Inc. | Electrical stimulation system, lead, and method providing reduced neuroplasticity effects |
US7289851B2 (en) | 2003-12-04 | 2007-10-30 | Medtronic, Inc. | Method and apparatus for identifying lead-related conditions using impedance trends and oversensing criteria |
US8060207B2 (en) | 2003-12-22 | 2011-11-15 | Boston Scientific Scimed, Inc. | Method of intravascularly delivering stimulation leads into direct contact with tissue |
CA2454184A1 (en) | 2003-12-23 | 2005-06-23 | Andres M. Lozano | Method and apparatus for treating neurological disorders by electrical stimulation of the brain |
US9623208B2 (en) | 2004-01-12 | 2017-04-18 | Varian Medical Systems, Inc. | Instruments with location markers and methods for tracking instruments through anatomical passageways |
US20090306728A1 (en) | 2004-01-12 | 2009-12-10 | Calypso Medical Technologies, Inc. | Methods and apparatus for stimulating and/or sensing neurons in a patient |
US20050171522A1 (en) | 2004-01-30 | 2005-08-04 | Christopherson Mark A. | Transurethral needle ablation system with needle position indicator |
CA2554836A1 (en) | 2004-02-05 | 2005-08-25 | Medtronic, Inc. | Methods and apparatus for identifying patients at risk for life threatening arrhythmias |
US7608458B2 (en) | 2004-02-05 | 2009-10-27 | Medtronic, Inc. | Identifying patients at risk for life threatening arrhythmias |
US7232435B2 (en) | 2004-02-06 | 2007-06-19 | Medtronic, Inc. | Delivery of a sympatholytic cardiovascular agent to the central nervous system to counter heart failure and pathologies associated with heart failure |
US7120499B2 (en) | 2004-02-12 | 2006-10-10 | Ndi Medical, Llc | Portable percutaneous assemblies, systems and methods for providing highly selective functional or therapeutic neuromuscular stimulation |
EP1720597A2 (en) | 2004-02-13 | 2006-11-15 | Medtronic, Inc. | Methods and apparatus for securing a therapy delivery device within a burr hole |
WO2005087314A1 (en) | 2004-03-11 | 2005-09-22 | Advanced Neuromodulation Systems, Inc. | Brain stimulation system and method |
WO2005089646A1 (en) | 2004-03-16 | 2005-09-29 | Medtronic, Inc. | Sensitivity analysis for selecting therapy parameter sets |
US7717848B2 (en) | 2004-03-16 | 2010-05-18 | Medtronic, Inc. | Collecting sleep quality information via a medical device |
US7395113B2 (en) | 2004-03-16 | 2008-07-01 | Medtronic, Inc. | Collecting activity information to evaluate therapy |
US7491181B2 (en) | 2004-03-16 | 2009-02-17 | Medtronic, Inc. | Collecting activity and sleep quality information via a medical device |
US7366572B2 (en) | 2004-03-16 | 2008-04-29 | Medtronic, Inc. | Controlling therapy based on sleep quality |
US7330760B2 (en) | 2004-03-16 | 2008-02-12 | Medtronic, Inc. | Collecting posture information to evaluate therapy |
US20080300652A1 (en) | 2004-03-17 | 2008-12-04 | Lim Hubert H | Systems and Methods for Inducing Intelligible Hearing |
US8989840B2 (en) | 2004-03-30 | 2015-03-24 | Medtronic, Inc. | Lead electrode for use in an MRI-safe implantable medical device |
US7174219B2 (en) | 2004-03-30 | 2007-02-06 | Medtronic, Inc. | Lead electrode for use in an MRI-safe implantable medical device |
EP1735048A4 (en) | 2004-04-06 | 2008-03-26 | John K Chapin | METHOD AND APPARATUS FOR TELEOPERATION, GUIDANCE AND TRAINING FOR ODOR DETECTION OF AN ANIMAL MOVING FREELY BY BRAIN STIMULATION |
US7313440B2 (en) | 2004-04-14 | 2007-12-25 | Medtronic, Inc. | Collecting posture and activity information to evaluate therapy |
GB0409109D0 (en) | 2004-04-23 | 2004-05-26 | Medtronic Inc | Deep brain stimulation |
US7463917B2 (en) | 2004-04-28 | 2008-12-09 | Medtronic, Inc. | Electrodes for sustained delivery of energy |
US7596399B2 (en) | 2004-04-29 | 2009-09-29 | Medtronic, Inc | Implantation of implantable medical device |
EP1744809A4 (en) | 2004-05-04 | 2008-05-07 | Univ Rochester | WIRELESS IMPLANTABLE INTRAVASCULAR ELECTROPHYSIOLOGICAL DEVICE FOR NEUROLOGICAL / CARDIOVASCULAR MEASUREMENT AND STIMULATION |
US7315759B2 (en) | 2004-05-07 | 2008-01-01 | Medtronic, Inc. | Implantable medical device with circulation delay measurement and therapy control |
US7837998B2 (en) | 2004-05-21 | 2010-11-23 | Nathaniel Lallatin | Anti-cancer activity of an anti-thymidine kinase monoclonal antibody |
WO2005117554A2 (en) | 2004-06-01 | 2005-12-15 | California Institute Of Technology | Microfabricated neural probes and methods of making same |
US7664551B2 (en) | 2004-07-07 | 2010-02-16 | Medtronic Transneuronix, Inc. | Treatment of the autonomic nervous system |
EP1786510A4 (en) | 2004-07-15 | 2009-12-02 | Northstar Neuroscience Inc | SYSTEMS AND METHOD FOR INCREASING OR INFLUENCING THE EFFICIENCY OR EFFECTIVENESS OF NEURAL STIMULATION |
US7614743B2 (en) | 2004-07-20 | 2009-11-10 | Medtronic, Inc. | Vital signs monitoring system with wireless pupilometer interface |
US7486993B2 (en) | 2004-08-05 | 2009-02-03 | Neurotone Systems, Inc. | Brain stimulation method and device |
WO2006031317A2 (en) | 2004-08-09 | 2006-03-23 | The Johns Hopkins University | Implantable mri compatible stimulation leads and antennas and related systems and methods |
US20060058627A1 (en) | 2004-08-13 | 2006-03-16 | Flaherty J C | Biological interface systems with wireless connection and related methods |
US20060041295A1 (en) | 2004-08-17 | 2006-02-23 | Osypka Thomas P | Positive fixation percutaneous epidural neurostimulation lead |
US20050154425A1 (en) | 2004-08-19 | 2005-07-14 | Boveja Birinder R. | Method and system to provide therapy for neuropsychiatric disorders and cognitive impairments using gradient magnetic pulses to the brain and pulsed electrical stimulation to vagus nerve(s) |
US7877149B2 (en) | 2004-09-02 | 2011-01-25 | Proteus Biomedical Inc. | Electrical angle gauge |
EP1799101A4 (en) | 2004-09-02 | 2008-11-19 | Proteus Biomedical Inc | METHOD AND DEVICES FOR TISSUE ACTIVATION AND MONITORING |
US7447546B2 (en) | 2004-09-08 | 2008-11-04 | Spinal Modulation, Inc. | Methods of neurostimulating targeted neural tissue |
WO2006034305A2 (en) | 2004-09-21 | 2006-03-30 | University Of Florida Research Foundation, Inc. | Multiple lead method for deep brain stimulation |
WO2006033021A2 (en) | 2004-09-22 | 2006-03-30 | Heartsine Technologies Limited | Sealed medical electrode package |
WO2006033110A2 (en) | 2004-09-24 | 2006-03-30 | Dov Ehrlich | Method and apparatus for treatment of tinnitus and other neurological disorders by brain stimulation in the inferior colliculi and/or in adjacent areas |
US7925329B2 (en) | 2004-10-08 | 2011-04-12 | Proteus Biomedical, Inc. | Implantable doppler tomography system |
US7229438B2 (en) | 2004-10-14 | 2007-06-12 | Boston Scientific Scimed, Inc. | Ablation probe with distal inverted electrode array |
US7578819B2 (en) | 2005-05-16 | 2009-08-25 | Baxano, Inc. | Spinal access and neural localization |
US7613519B2 (en) | 2004-10-21 | 2009-11-03 | Advanced Neuromodulation Systems, Inc. | Peripheral nerve stimulation to treat auditory dysfunction |
US7519432B2 (en) | 2004-10-21 | 2009-04-14 | Medtronic, Inc. | Implantable medical lead with helical reinforcement |
EP1827580A1 (en) | 2004-10-21 | 2007-09-05 | Advanced Neuromodulation Systems, Inc. | New stimulation design for neuromodulation |
US7729780B2 (en) | 2004-10-21 | 2010-06-01 | Vardiman Arnold B | Various apparatus and methods for deep brain stimulating electrodes |
US7322832B2 (en) | 2004-10-26 | 2008-01-29 | Medtronic, Inc. | Radio frequency antenna flexible circuit interconnect with unique micro connectors |
US7524318B2 (en) | 2004-10-28 | 2009-04-28 | Boston Scientific Scimed, Inc. | Ablation probe with flared electrodes |
US7582387B2 (en) | 2004-10-29 | 2009-09-01 | Medtronic, Inc. | Lithium-ion battery |
US7807299B2 (en) | 2004-10-29 | 2010-10-05 | Medtronic, Inc. | Lithium-ion battery |
WO2006050117A2 (en) | 2004-10-29 | 2006-05-11 | Medtronic, Inc. | Method of charging lithium-ion battery |
US7641992B2 (en) | 2004-10-29 | 2010-01-05 | Medtronic, Inc. | Medical device having lithium-ion battery |
US7526340B2 (en) | 2004-10-29 | 2009-04-28 | Medtronic, Inc. | Division approximation for implantable medical devices |
US7662509B2 (en) | 2004-10-29 | 2010-02-16 | Medtronic, Inc. | Lithium-ion battery |
US7879495B2 (en) | 2004-10-29 | 2011-02-01 | Medtronic, Inc. | Medical device having lithium-ion battery |
US7811705B2 (en) | 2004-10-29 | 2010-10-12 | Medtronic, Inc. | Lithium-ion battery |
WO2006050385A2 (en) | 2004-11-01 | 2006-05-11 | Proteus Biomedical, Inc. | Cardiac motion characterization by strain measurement |
US7288066B2 (en) | 2004-11-01 | 2007-10-30 | Medtronic, Inc. | Data compression method for implantable medical devices |
US7497863B2 (en) | 2004-12-04 | 2009-03-03 | Medtronic, Inc. | Instrument guiding stage apparatus and method for using same |
US7937160B2 (en) | 2004-12-10 | 2011-05-03 | Boston Scientific Neuromodulation Corporation | Methods for delivering cortical electrode leads into patient's head |
US7819812B2 (en) | 2004-12-15 | 2010-10-26 | Neuropace, Inc. | Modulation and analysis of cerebral perfusion in epilepsy and other neurological disorders |
US8000795B2 (en) | 2004-12-17 | 2011-08-16 | Lozano Andres M | Cognitive function within a human brain |
US8041419B2 (en) | 2004-12-17 | 2011-10-18 | Medtronic, Inc. | System and method for monitoring or treating nervous system disorders |
US9327069B2 (en) | 2004-12-21 | 2016-05-03 | Boston Scientific Neuromodulation Corporation | Methods and systems for treating a medical condition by promoting neural remodeling within the brain |
US20080255647A1 (en) | 2004-12-22 | 2008-10-16 | Marc Jensen | Implantable Addressable Segmented Electrodes |
US8195308B2 (en) | 2004-12-22 | 2012-06-05 | Proteus Biomedical, Inc. | Implantable hermetically sealed structures |
US20080077186A1 (en) | 2006-04-18 | 2008-03-27 | Proteus Biomedical, Inc. | High phrenic, low capture threshold pacing devices and methods |
US7783359B2 (en) | 2005-01-05 | 2010-08-24 | Boston Scientific Neuromodulation Corporation | Devices and methods using an implantable pulse generator for brain stimulation |
US7809446B2 (en) | 2005-01-05 | 2010-10-05 | Boston Scientific Neuromodulation Corporation | Devices and methods for brain stimulation |
US7400927B1 (en) | 2005-01-06 | 2008-07-15 | Chester Litvin | Method and system for psychological treatment by brain stimulation of the psychologically disordered object |
US8788044B2 (en) | 2005-01-21 | 2014-07-22 | Michael Sasha John | Systems and methods for tissue stimulation in medical treatment |
US8600521B2 (en) | 2005-01-27 | 2013-12-03 | Cyberonics, Inc. | Implantable medical device having multiple electrode/sensor capability and stimulation based on sensed intrinsic activity |
ATE448830T1 (de) | 2005-01-31 | 2009-12-15 | Medtronic Inc | Verfahren zur herstellung einer medizinischen leitung |
US7447543B2 (en) | 2005-02-15 | 2008-11-04 | Regents Of The University Of Minnesota | Pathology assessment with impedance measurements using convergent bioelectric lead fields |
US7657316B2 (en) | 2005-02-25 | 2010-02-02 | Boston Scientific Neuromodulation Corporation | Methods and systems for stimulating a motor cortex of the brain to treat a medical condition |
WO2006094072A2 (en) | 2005-03-01 | 2006-09-08 | Functional Neuroscience Inc. | Method of treating cognitive disorders using neuromodulation |
US8244347B2 (en) | 2005-03-04 | 2012-08-14 | Andres M. Lozano | Methods and apparatus for effectuating a lasting change in a neural function of a patient, including via mechanical force on neural tissue |
US7591970B2 (en) | 2005-03-07 | 2009-09-22 | Medtronic, Inc. | Medical device anchor and method of manufacture thereof |
US7231256B2 (en) | 2005-03-11 | 2007-06-12 | Medtronic, Inc. | Neurostimulation site screening |
US7555345B2 (en) | 2005-03-11 | 2009-06-30 | Medtronic, Inc. | Implantable neurostimulator device |
AU2006222983B2 (en) | 2005-03-15 | 2012-08-16 | The Regents Of The University Of California | Method and system for modulating energy expenditure and neurotrophic factors |
US7729768B2 (en) | 2005-03-25 | 2010-06-01 | Proteus Biomedical, Inc. | Implantable cardiac motion powered piezoelectric energy source |
US7594889B2 (en) | 2005-03-31 | 2009-09-29 | Medtronic, Inc. | Integrated data collection and analysis for clinical study |
US7321798B2 (en) | 2005-03-31 | 2008-01-22 | Medtronic, Inc. | Trans-septal/trans-myocardial ventricular pacing lead |
US8036743B2 (en) | 2005-03-31 | 2011-10-11 | Proteus Biomedical, Inc. | Automated optimization of multi-electrode pacing for cardiac resynchronization |
US7421297B2 (en) | 2005-03-31 | 2008-09-02 | Medtronic, Inc. | Monopolar stimulation assembly including at least one remote electrode |
US20090292346A1 (en) | 2005-03-31 | 2009-11-26 | St. Jude Medical Ab | Porous Niobium Oxide as Electrode Material and Manufacturing Process |
US7519431B2 (en) | 2005-04-11 | 2009-04-14 | Medtronic, Inc. | Shifting between electrode combinations in electrical stimulation device |
US8078275B2 (en) | 2005-04-15 | 2011-12-13 | Functional Neuromodulation Inc. | Regulation of neurotrophins |
US8836513B2 (en) | 2006-04-28 | 2014-09-16 | Proteus Digital Health, Inc. | Communication system incorporated in an ingestible product |
US8802183B2 (en) | 2005-04-28 | 2014-08-12 | Proteus Digital Health, Inc. | Communication system with enhanced partial power source and method of manufacturing same |
US7406351B2 (en) | 2005-04-28 | 2008-07-29 | Medtronic, Inc. | Activity sensing for stimulator control |
EP2671508B1 (en) | 2005-04-28 | 2020-09-16 | Proteus Digital Health, Inc. | Pharma-informatics system |
US8730031B2 (en) | 2005-04-28 | 2014-05-20 | Proteus Digital Health, Inc. | Communication system using an implantable device |
US20120004520A1 (en) | 2005-04-28 | 2012-01-05 | Proteus Biomedical, Inc. | Communication System with Multiple Sources of Power |
US7623923B2 (en) | 2005-04-28 | 2009-11-24 | Medtronic, Inc. | Tube sensor for penile tumescence |
US8912908B2 (en) | 2005-04-28 | 2014-12-16 | Proteus Digital Health, Inc. | Communication system with remote activation |
US7389147B2 (en) | 2005-04-29 | 2008-06-17 | Medtronic, Inc. | Therapy delivery mode selection |
US9743878B2 (en) | 2005-04-29 | 2017-08-29 | Medtronic, Inc. | Event-based lead impedance monitoring |
DE602006010995D1 (de) | 2005-04-29 | 2010-01-21 | Medtronic Inc | Funktionstest für verteilte leitungskabel |
US7515961B2 (en) | 2005-04-29 | 2009-04-07 | Medtronic, Inc. | Method and apparatus for dynamically monitoring, detecting and diagnosing lead conditions |
DE102005019968A1 (de) | 2005-04-29 | 2006-11-02 | Valerij Ortmann | Biostabile Neuroelektrode |
WO2006119046A1 (en) | 2005-04-30 | 2006-11-09 | Medtronic, Inc. | Impedance-based stimulation adjustment |
US8024022B2 (en) | 2005-05-25 | 2011-09-20 | Alfred E. Mann Foundation For Scientific Research | Hermetically sealed three-dimensional electrode array |
US20090318824A1 (en) | 2005-06-01 | 2009-12-24 | University Of Florida Research Foundation Inc. | Neuralprobe and methods for manufacturing same |
US8831739B2 (en) | 2005-06-02 | 2014-09-09 | Huntington Medical Research Institutes | Microelectrode array for chronic deep-brain microstimulation for recording |
WO2006138358A2 (en) | 2005-06-14 | 2006-12-28 | The Regents Of The University Of Michigan Technology Management Office | Flexible polymer microelectrode with fluid delivery capability and methods for making same |
CN101578119A (zh) | 2005-06-16 | 2009-11-11 | 迈克尔·J·拉塞尔 | 引导的经颅电刺激技术 |
WO2007002144A2 (en) | 2005-06-23 | 2007-01-04 | University Of Florida Research Foundation, Inc. | Brain stimulation method for weight control |
US20060293721A1 (en) | 2005-06-28 | 2006-12-28 | Cyberonics, Inc. | Vagus nerve stimulation for treatment of depression with therapeutically beneficial parameter settings |
WO2007011611A2 (en) | 2005-07-12 | 2007-01-25 | Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California | Deep brain neural prosthetic system |
US7769472B2 (en) | 2005-07-29 | 2010-08-03 | Medtronic, Inc. | Electrical stimulation lead with conformable array of electrodes |
US7680540B2 (en) | 2005-07-29 | 2010-03-16 | Medtronic, Inc. | Multi-application trial stimulator |
US7532935B2 (en) | 2005-07-29 | 2009-05-12 | Cyberonics, Inc. | Selective neurostimulation for treating mood disorders |
US7499752B2 (en) | 2005-07-29 | 2009-03-03 | Cyberonics, Inc. | Selective nerve stimulation for the treatment of eating disorders |
US7822482B2 (en) | 2005-07-29 | 2010-10-26 | Medtronic, Inc. | Electrical stimulation lead with rounded array of electrodes |
WO2007021804A2 (en) | 2005-08-12 | 2007-02-22 | Proteus Biomedical, Inc. | Evaluation of depolarization wave conduction velocity |
US8005526B2 (en) | 2005-08-31 | 2011-08-23 | The Regents Of The University Of Michigan | Biologically integrated electrode devices |
EP1759725A1 (fr) | 2005-08-31 | 2007-03-07 | Université Libre De Bruxelles | Sonde electro-biochimique d'analyse intramusculaire ou intracerebrale |
US7551960B2 (en) | 2005-09-08 | 2009-06-23 | Medtronic, Inc. | External presentation of electrical stimulation parameters |
US7640059B2 (en) | 2005-09-08 | 2009-12-29 | Medtronic, Inc. | External presentation of electrical stimulation parameters |
US8649876B2 (en) | 2005-09-10 | 2014-02-11 | Artann Laboratories Inc. | Leadless system for deep brain stimulation using time reversal acoustics |
US8374696B2 (en) | 2005-09-14 | 2013-02-12 | University Of Florida Research Foundation, Inc. | Closed-loop micro-control system for predicting and preventing epileptic seizures |
US20070225773A1 (en) | 2005-09-28 | 2007-09-27 | Yang Shen | Implantable transcranial pulse generator having a collapsible portion |
US8271094B1 (en) | 2005-09-30 | 2012-09-18 | Boston Scientific Neuromodulation Corporation | Devices with cannula and electrode lead for brain stimulation and methods of use and manufacture |
EP1931419B1 (en) | 2005-10-07 | 2016-08-10 | NeuroNexus Technologies, Inc. | Modular multichannel microelectrode array |
US7725192B2 (en) | 2005-10-12 | 2010-05-25 | The General Hospital Corporation | Methods of increasing learning rate |
US20070088404A1 (en) | 2005-10-19 | 2007-04-19 | Allen Wyler | Methods and systems for improving neural functioning, including cognitive functioning and neglect disorders |
US7729773B2 (en) | 2005-10-19 | 2010-06-01 | Advanced Neuromodualation Systems, Inc. | Neural stimulation and optical monitoring systems and methods |
US20070088403A1 (en) | 2005-10-19 | 2007-04-19 | Allen Wyler | Methods and systems for establishing parameters for neural stimulation |
US7620455B2 (en) | 2005-10-25 | 2009-11-17 | Cyberonics, Inc. | Cranial nerve stimulation to treat eating disorders |
US7555344B2 (en) | 2005-10-28 | 2009-06-30 | Cyberonics, Inc. | Selective neurostimulation for treating epilepsy |
US7590451B2 (en) | 2005-10-31 | 2009-09-15 | Medtronic, Inc. | Axial lead connector for implantable medical devices |
US7684867B2 (en) | 2005-11-01 | 2010-03-23 | Boston Scientific Neuromodulation Corporation | Treatment of aphasia by electrical stimulation and/or drug infusion |
US20070106143A1 (en) | 2005-11-08 | 2007-05-10 | Flaherty J C | Electrode arrays and related methods |
US8224462B2 (en) | 2005-11-11 | 2012-07-17 | Greatbatch Ltd. | Medical lead system utilizing electromagnetic bandstop filters |
US8204586B2 (en) | 2005-11-22 | 2012-06-19 | Proteus Biomedical, Inc. | External continuous field tomography |
WO2007075477A2 (en) | 2005-12-19 | 2007-07-05 | University Of Florida | Closed-loop state-dependent seizure prevention systems |
US20070142872A1 (en) | 2005-12-21 | 2007-06-21 | Mickle Marlin H | Deep brain stimulation apparatus, and associated methods |
US8868172B2 (en) | 2005-12-28 | 2014-10-21 | Cyberonics, Inc. | Methods and systems for recommending an appropriate action to a patient for managing epilepsy and other neurological disorders |
US7603161B2 (en) | 2005-12-30 | 2009-10-13 | Medtronic, Inc. | Position detection in a magnetic field |
US7957808B2 (en) | 2006-01-13 | 2011-06-07 | Vanderbilt University | System and methods of deep brain stimulation for post-operation patients |
US20070173908A1 (en) | 2006-01-20 | 2007-07-26 | Cyberonics, Inc. | Transcutaneous trigeminal nerve stimulation to treat motion sickness |
US7606622B2 (en) | 2006-01-24 | 2009-10-20 | Cardiac Pacemakers, Inc. | Method and device for detecting and treating depression |
US20070173890A1 (en) | 2006-01-24 | 2007-07-26 | Cyberonics, Inc. | Stimulation mode adjustment for an implantable medical device |
US8195267B2 (en) | 2006-01-26 | 2012-06-05 | Seymour John P | Microelectrode with laterally extending platform for reduction of tissue encapsulation |
US20070179558A1 (en) | 2006-01-30 | 2007-08-02 | Gliner Bradford E | Systems and methods for varying electromagnetic and adjunctive neural therapies |
WO2007092330A1 (en) | 2006-02-03 | 2007-08-16 | Synecor, Llc | Intravascular device for neuromodulation |
US7914842B1 (en) | 2006-02-10 | 2011-03-29 | Second Sight Medical Products, Inc | Method of manufacturing a flexible circuit electrode array |
US20070197892A1 (en) | 2006-02-23 | 2007-08-23 | Medtrode Inc. | Non-planar multi-channel electrode array |
US7657319B2 (en) | 2006-02-24 | 2010-02-02 | Medtronic, Inc. | Programming interface with an unwrapped 2D view of a stimulation lead with complex electrode array geometry |
US7676273B2 (en) | 2006-02-24 | 2010-03-09 | Medtronic, Inc. | Stimulation templates for programming a stimulation lead with complex electrode array geometry |
US7822483B2 (en) | 2006-02-24 | 2010-10-26 | Medtronic, Inc. | Electrical and activation field models for configuring stimulation therapy |
US8209018B2 (en) | 2006-03-10 | 2012-06-26 | Medtronic, Inc. | Probabilistic neurological disorder treatment |
US20070213784A1 (en) | 2006-03-13 | 2007-09-13 | Neuropace, Inc. | Seizure therapy and suppression using an implantable device |
US7689289B2 (en) | 2006-03-22 | 2010-03-30 | Medtronic, Inc. | Technique for adjusting the locus of excitation of electrically excitable tissue with paired pulses |
EP1997527A4 (en) | 2006-03-23 | 2012-11-07 | Valery Pavlovich Lebedev | TRANSCRANIAL ELECTROSTIMULATION DEVICE |
US8010203B2 (en) | 2006-03-23 | 2011-08-30 | Medtronic, Inc. | Guided programming with feedback |
US8190251B2 (en) | 2006-03-24 | 2012-05-29 | Medtronic, Inc. | Method and apparatus for the treatment of movement disorders |
KR101320085B1 (ko) | 2006-03-24 | 2013-10-18 | 메드트로닉 인코포레이티드 | 이식의료기구 및 리튬 전지 |
US7526339B2 (en) | 2006-03-27 | 2009-04-28 | Medtronic, Inc. | IPG connector headers for implantable medical devices |
JP5415255B2 (ja) | 2006-03-29 | 2014-02-12 | ディグニティー ヘルス | 病状治療用の脳神経マイクロバースト電気刺激 |
US7949401B2 (en) | 2006-04-11 | 2011-05-24 | Advanced Neuromodulation Systems, Inc. | Electromagnetic signal delivery for tissue affected by neuronal dysfunction, degradation, damage, and/or necrosis, and associated systems and methods |
US20080269835A1 (en) | 2006-04-21 | 2008-10-30 | Medtronic, Inc. | Method and apparatus for detection of nervous system disorders |
US7761145B2 (en) | 2006-04-21 | 2010-07-20 | Medtronic, Inc. | Method and apparatus for detection of nervous system disorders |
US8165683B2 (en) | 2006-04-21 | 2012-04-24 | Medtronic, Inc. | Method and apparatus for detection of nervous system disorders |
US20070249953A1 (en) | 2006-04-21 | 2007-10-25 | Medtronic, Inc. | Method and apparatus for detection of nervous system disorders |
WO2007123428A1 (en) | 2006-04-24 | 2007-11-01 | Volastic Co. Limited | Injection moulding nozzle and tip therefor |
US7610083B2 (en) | 2006-04-27 | 2009-10-27 | Medtronic, Inc. | Method and system for loop recording with overlapping events |
US7359837B2 (en) | 2006-04-27 | 2008-04-15 | Medtronic, Inc. | Peak data retention of signal data in an implantable medical device |
US7660630B2 (en) | 2006-04-27 | 2010-02-09 | Medtronic, Inc. | Variable implantable medical device power characteristics based upon implant depth |
US9084901B2 (en) | 2006-04-28 | 2015-07-21 | Medtronic, Inc. | Cranial implant |
US7715920B2 (en) | 2006-04-28 | 2010-05-11 | Medtronic, Inc. | Tree-based electrical stimulator programming |
US8326431B2 (en) | 2006-04-28 | 2012-12-04 | Medtronic, Inc. | Implantable medical device for the concurrent treatment of a plurality of neurological disorders and method therefore |
US7962220B2 (en) | 2006-04-28 | 2011-06-14 | Cyberonics, Inc. | Compensation reduction in tissue stimulation therapy |
US8086316B2 (en) | 2006-05-24 | 2011-12-27 | Drexel University | Wireless controlled neuromodulation system |
US7894904B2 (en) | 2006-06-20 | 2011-02-22 | Ebr Systems, Inc. | Systems and methods for implantable leadless brain stimulation |
WO2008005153A2 (en) | 2006-06-30 | 2008-01-10 | Medtronic, Inc. | Selecting electrode combinations for stimulation therapy |
WO2008003318A1 (en) | 2006-07-05 | 2008-01-10 | Aarhus Universitet | A research model system and a method for using electrical stimulation and/ chemical stimulation to induce depressive illness in research animals |
ES2664415T3 (es) | 2006-07-05 | 2018-04-19 | Precisis Ag | Sistema para el tratamiento de trastornos neurológicos mediante estimulación eléctrica |
DE102006036069B4 (de) | 2006-07-18 | 2008-09-04 | Cerbomed Gmbh | Audiologisches Übertragungssystem |
US8073545B2 (en) | 2006-07-21 | 2011-12-06 | Neuropace, Inc. | Treatment and warning of recurring therapy and other events using an implantable device |
US7996088B2 (en) | 2006-07-26 | 2011-08-09 | Cyberonics, Inc. | Vagus nerve stimulation by electrical signals for controlling cerebellar tremor |
US8682445B2 (en) | 2006-07-28 | 2014-03-25 | Cyberonics, Inc. | Patient management system for treating depression using an implantable medical device |
US20080027540A1 (en) | 2006-07-31 | 2008-01-31 | Cumming J Stuart | Stabilized accommodating intraocular lens |
US7583999B2 (en) | 2006-07-31 | 2009-09-01 | Cranial Medical Systems, Inc. | Multi-channel connector for brain stimulation system |
US8321025B2 (en) | 2006-07-31 | 2012-11-27 | Cranial Medical Systems, Inc. | Lead and methods for brain monitoring and modulation |
US20080103548A1 (en) | 2006-08-02 | 2008-05-01 | Northstar Neuroscience, Inc. | Methods for treating neurological disorders, including neuropsychiatric and neuropsychological disorders, and associated systems |
ES2699474T3 (es) | 2006-08-07 | 2019-02-11 | Alpha Omega Neuro Tech Ltd | Electrodos cerebrales |
US8909342B2 (en) | 2006-08-15 | 2014-12-09 | Andres M. Lozano | Method for treating eating disorders |
WO2008025155A1 (en) | 2006-08-29 | 2008-03-06 | Victhom Human Bionics Inc. | Nerve cuff injection mold and method of making a nerve cuff |
US8172762B2 (en) | 2006-09-01 | 2012-05-08 | Proteus Biomedical, Inc. | Simultaneous blood flow and hematocrit sensor |
US9162051B2 (en) | 2006-09-21 | 2015-10-20 | Neuropace, Inc. | Treatment of language, behavior and social disorders |
WO2008035344A2 (en) | 2006-09-22 | 2008-03-27 | Bar-Ilan University | A device and method for deep brain stimulation as a new form of treating chronic depression |
JP2010504128A (ja) | 2006-09-22 | 2010-02-12 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 植込み型多電極装置 |
RU2463088C2 (ru) | 2006-09-26 | 2012-10-10 | Сапиенс Стиринг Брейн Стимулейшн Б.В. | Способ и устройство для стимуляции тканей |
US8244377B1 (en) | 2006-09-27 | 2012-08-14 | Boston Scientific Neuromodulation Corporation | Fixation arrangements for implantable leads and methods of making and using |
US20110040204A1 (en) | 2006-10-19 | 2011-02-17 | The Regents Of The University Of California | Neurological stimulation and analysis |
US7684873B2 (en) | 2006-10-31 | 2010-03-23 | Medtronic, Inc. | Implantable medical lead including a directional electrode and fixation elements along an interior surface |
US20080103578A1 (en) | 2006-10-31 | 2008-05-01 | Medtronic, Inc. | Implantable medical elongated member with in situ formed fixation element |
US8280514B2 (en) | 2006-10-31 | 2012-10-02 | Advanced Neuromodulation Systems, Inc. | Identifying areas of the brain by examining the neuronal signals |
US8295934B2 (en) | 2006-11-14 | 2012-10-23 | Neurovista Corporation | Systems and methods of reducing artifact in neurological stimulation systems |
US7853303B2 (en) | 2006-11-16 | 2010-12-14 | National Research Council Of Canada | Neurological probe and method of using same |
WO2008064269A2 (en) | 2006-11-20 | 2008-05-29 | Second Sight Medical Products, Inc. | Method of improving electrode tissue interface |
US7765012B2 (en) | 2006-11-30 | 2010-07-27 | Medtronic, Inc. | Implantable medical device including a conductive fixation element |
WO2008070142A2 (en) | 2006-12-06 | 2008-06-12 | Medtronic, Inc. | User interface with toolbar for programming electrical stimulation therapy |
WO2008070809A2 (en) | 2006-12-06 | 2008-06-12 | Spinal Modulation, Inc. | Implantable flexible circuit leads and methods of use |
US20100114272A1 (en) | 2006-12-07 | 2010-05-06 | Sebastian Haidarliu | Multiple micro-wire electrode device and methods |
US20080139870A1 (en) | 2006-12-12 | 2008-06-12 | Northstar Neuroscience, Inc. | Systems and methods for treating patient hypertonicity |
EP2091606B1 (en) | 2006-12-13 | 2016-05-25 | Medtronic Bakken Research Center B.V. | First time right placement of a dbs lead |
WO2008076925A2 (en) | 2006-12-15 | 2008-06-26 | Proteus Biomedical, Inc. | Universal connector for implantable medical device |
FR2909883B1 (fr) | 2006-12-18 | 2012-11-30 | Commissariat Energie Atomique | Sonde a bras multiples et systeme pour neurostimulation electrique profonde comportant une telle sonde |
US20080154331A1 (en) | 2006-12-21 | 2008-06-26 | Varghese John | Device for multicentric brain modulation, repair and interface |
WO2008075294A1 (en) | 2006-12-21 | 2008-06-26 | Koninklijke Philips Electronics, N.V. | Biomimetic neurostimulation device |
US8700167B2 (en) | 2006-12-22 | 2014-04-15 | Ebs Technologies Gmbh | Apparatus and method for stimulating a brain of a person |
US20080172103A1 (en) | 2007-01-17 | 2008-07-17 | Vanderbilt University | Methods and system for brain stimulation |
US7711428B2 (en) | 2007-01-18 | 2010-05-04 | Medtronic, Inc. | Hermetic lead connector assembly |
US8095210B2 (en) | 2007-01-19 | 2012-01-10 | California Institute Of Technology | Prosthetic devices and methods and systems related thereto |
US8014863B2 (en) | 2007-01-19 | 2011-09-06 | Cardiac Pacemakers, Inc. | Heart attack or ischemia detector |
DE102007003799A1 (de) | 2007-01-25 | 2008-07-31 | Anm Adaptive Neuromodulation Gmbh | Implantat zur Stimulation von Nervenzellen |
US7917230B2 (en) | 2007-01-30 | 2011-03-29 | Cardiac Pacemakers, Inc. | Neurostimulating lead having a stent-like anchor |
US7385443B1 (en) | 2007-01-31 | 2008-06-10 | Medtronic, Inc. | Chopper-stabilized instrumentation amplifier |
US7391257B1 (en) | 2007-01-31 | 2008-06-24 | Medtronic, Inc. | Chopper-stabilized instrumentation amplifier for impedance measurement |
US20080188905A1 (en) | 2007-02-02 | 2008-08-07 | Somatics Llc | Stimulus dose system and method for electroconvulsive therapy |
US8755896B2 (en) | 2007-02-05 | 2014-06-17 | University Of Southern California | Treatment of consumption disorders with biostimulation |
US7844345B2 (en) | 2007-02-08 | 2010-11-30 | Neuropace, Inc. | Drug eluting lead systems |
US7894890B2 (en) | 2007-02-09 | 2011-02-22 | Neuropace, Inc. | Devices and methods for monitoring physiological information relating to sleep with an implantable device |
US8956288B2 (en) | 2007-02-14 | 2015-02-17 | Proteus Digital Health, Inc. | In-body power source having high surface area electrode |
US7502217B2 (en) | 2007-02-16 | 2009-03-10 | Medtronic, Inc. | Filtering capacitor feedthrough assembly |
US7594828B2 (en) | 2007-02-26 | 2009-09-29 | Medtronic, Inc. | Implantable neurostimulator adapters |
US8731673B2 (en) | 2007-02-26 | 2014-05-20 | Sapiens Steering Brain Stimulation B.V. | Neural interface system |
US7563141B2 (en) | 2007-02-26 | 2009-07-21 | Medtronic, Inc. | Implantable neurostimulator adapters |
US7949403B2 (en) | 2007-02-27 | 2011-05-24 | Accelerated Care Plus Corp. | Electrical stimulation device and method for the treatment of neurological disorders |
WO2008107822A1 (en) | 2007-03-02 | 2008-09-12 | Koninklijke Philips Electronics N.V. | Electrode system for deep brain stimulation |
WO2008107815A1 (en) | 2007-03-02 | 2008-09-12 | Koninklijke Philips Electronics N.V. | Electrode system for deep brain stimulation |
EP2121125B1 (en) | 2007-03-09 | 2015-12-30 | Medtronic, Inc. | Medical device electrical lead design for preventing transmittance of unsafe currents to a patient |
US7429938B1 (en) | 2007-03-26 | 2008-09-30 | Medtronic, Inc. | Method of compressing waveform data with differential entropy based compression |
US20080242976A1 (en) | 2007-03-30 | 2008-10-02 | Proteus Biomedical, Inc. | Electric field tomography |
US20080262332A1 (en) | 2007-04-19 | 2008-10-23 | Medtronic, Inc. | Infection monitoring |
US7604629B2 (en) | 2007-04-19 | 2009-10-20 | Medtronic Inc. | Multi-parameter infection monitoring |
US7682355B2 (en) | 2007-04-19 | 2010-03-23 | Medtronic, Inc. | Refined infection monitoring |
US7668601B2 (en) | 2007-04-26 | 2010-02-23 | Medtronic, Inc. | Implantable medical lead with multiple electrode configurations |
WO2008133616A1 (en) | 2007-04-26 | 2008-11-06 | Medtronic, Inc. | Implantable medical lead with multiple electrode configurations |
WO2008133683A1 (en) | 2007-04-27 | 2008-11-06 | Medtronic, Inc. | Implantable medical device for treating neurological conditions with an initially disabled cardiac therepy port and leadless ecg sensing |
US8000788B2 (en) | 2007-04-27 | 2011-08-16 | Medtronic, Inc. | Implantable medical device for treating neurological conditions including ECG sensing |
EP1985579B1 (en) | 2007-04-27 | 2018-01-10 | IMEC vzw | Connecting scheme for the orthogonal assembly of microstructures |
DE102007022960A1 (de) | 2007-05-16 | 2008-11-20 | Forschungszentrum Jülich GmbH | Stimulationsvorrichtung |
US8115618B2 (en) | 2007-05-24 | 2012-02-14 | Proteus Biomedical, Inc. | RFID antenna for in-body device |
DE202008018476U1 (de) | 2007-06-04 | 2014-04-15 | Sapiens Steering Brain Stimulation B.V. | Einsatzsystem und Führung zur Behandlung einer Zielgeweberegion |
US8090450B2 (en) | 2007-06-27 | 2012-01-03 | Greatbatch Ltd. | Percutaneous electrode array and system |
WO2009001327A2 (en) | 2007-06-27 | 2008-12-31 | Flip Technologies Limited | A catheter and a method for producing a catheter |
FR2918285A1 (fr) | 2007-07-03 | 2009-01-09 | Commissariat Energie Atomique | Sonde a electrodes multiples et systeme pour neurostimulation electrique profonde comportant une telle sonde |
JP5539867B2 (ja) | 2007-07-10 | 2014-07-02 | サピエンス ステアリング ブレイン スティムレーション ベー ヴィ | 神経刺激システム |
WO2009009724A1 (en) | 2007-07-11 | 2009-01-15 | Mayo Foundation For Medical Education And Research | Seizure forecasting, microseizure precursor events, and related therapeutic methods and devices |
US20090027504A1 (en) | 2007-07-25 | 2009-01-29 | Suk Hwan Lim | System and method for calibrating a camera |
US9592377B2 (en) | 2007-07-27 | 2017-03-14 | Second Sight Medical Products, Inc. | Implantable device for the brain |
WO2009025824A1 (en) | 2007-08-20 | 2009-02-26 | Medtronic, Inc. | Implantable medical lead with biased electrode |
EP2069005A4 (en) | 2007-08-31 | 2010-12-15 | Proteus Biomedical Inc | SELF-RELATED COMMUNICATION IN IMPLANTABLE DEVICES |
EP2192946B1 (en) | 2007-09-25 | 2022-09-14 | Otsuka Pharmaceutical Co., Ltd. | In-body device with virtual dipole signal amplification |
US7623053B2 (en) | 2007-09-26 | 2009-11-24 | Medtronic, Inc. | Implantable medical device with low power delta-sigma analog-to-digital converter |
US7479910B1 (en) | 2007-09-26 | 2009-01-20 | Medtronic, Inc. | Capacitive digital-to-analog converter reset in an implantable medical device analog-to-digital converter |
US7474247B1 (en) | 2007-09-26 | 2009-01-06 | Medtronic, Inc. | Detecting overloading of an analog-to-digital converter of an implantable medical device |
US8224417B2 (en) | 2007-10-17 | 2012-07-17 | Neuronexus Technologies, Inc. | Guide tube for an implantable device system |
US8565894B2 (en) | 2007-10-17 | 2013-10-22 | Neuronexus Technologies, Inc. | Three-dimensional system of electrode leads |
WO2009052425A1 (en) | 2007-10-17 | 2009-04-23 | Neuronexus Technologies | Implantable device including a resorbable carrier |
WO2009052480A2 (en) | 2007-10-18 | 2009-04-23 | Integrated Sensing Systems, Inc. | Miniature wireless system for deep brain stimulation |
US9008782B2 (en) | 2007-10-26 | 2015-04-14 | Medtronic, Inc. | Occipital nerve stimulation |
US8355768B2 (en) | 2007-12-17 | 2013-01-15 | California Institute Of Technology | Micromachined neural probes |
WO2009097493A2 (en) | 2008-01-30 | 2009-08-06 | New York University | Cortical electrode array and method for stimulating and recording brain activity |
US8055353B2 (en) | 2008-02-12 | 2011-11-08 | Proteus Biomedical, Inc. | Medical carriers comprising a low-impedance conductor, and methods of making and using the same |
US8019440B2 (en) | 2008-02-12 | 2011-09-13 | Intelect Medical, Inc. | Directional lead assembly |
WO2009100531A1 (en) * | 2008-02-15 | 2009-08-20 | Angeltear Solutions Inc. | Adjustable tissue or nerve cuff and method of use |
WO2009131749A2 (en) | 2008-02-28 | 2009-10-29 | Proteus Biomedical, Inc. | Integrated circuit implementation and fault control system, device, and method |
US8498720B2 (en) | 2008-02-29 | 2013-07-30 | Neuronexus Technologies, Inc. | Implantable electrode and method of making the same |
CA2717862C (en) | 2008-03-05 | 2016-11-22 | Proteus Biomedical, Inc. | Multi-mode communication ingestible event markers and systems, and methods of using the same |
US20090240314A1 (en) | 2008-03-24 | 2009-09-24 | Kong K C | Implantable electrode lead system with a three dimensional arrangement and method of making the same |
US20090248122A1 (en) | 2008-03-28 | 2009-10-01 | Boston Scientific Neuromodulation Corporation | Multi-conductor ribbon for a lead assembly of an implantable electric stimulation system and methods of making and using |
US20090292325A1 (en) | 2008-05-02 | 2009-11-26 | Cederna Paul S | Hybrid bioelectrical interface device |
JP5420644B2 (ja) | 2008-05-28 | 2014-02-19 | サピエンス ステアリング ブレイン スティムレーション ベー ヴィ | 電気生理学的信号のスパイク検出に対する閾値を決定する方法及びシステム |
DE102008002331A1 (de) | 2008-06-10 | 2009-12-17 | Biotronik Crm Patent Ag | Elektrotherapieeinrichtung zur Behandlung tachykarder Rythmusstörungen eines Herzens |
US8852206B2 (en) | 2008-06-12 | 2014-10-07 | The Regents Of The University Of Michigan | Probe insertion device for implanting a probe into tissue |
US8608664B2 (en) | 2008-06-20 | 2013-12-17 | University Of Miyazaki | Electrode |
US8218580B2 (en) | 2008-07-15 | 2012-07-10 | Intel Corporation | Managing timing of a protocol stack |
JP5653918B2 (ja) | 2008-07-30 | 2015-01-14 | エコーレ ポリテクニーク フェデラーレ デ ローザンヌ (イーピーエフエル) | 神経標的の最適化された刺激のための装置および方法 |
KR101214453B1 (ko) | 2008-08-13 | 2012-12-24 | 프로테우스 디지털 헬스, 인코포레이티드 | 복용 가능한 회로 |
US20100076535A1 (en) | 2008-09-25 | 2010-03-25 | Boston Scientific Neuromodulation Corporation | Leads with non-circular-shaped distal ends for brain stimulation systems and methods of making and using |
US8364279B2 (en) | 2008-09-25 | 2013-01-29 | Boston Scientific Neuromodulation Corporation | Electrical stimulation leads having RF compatibility and methods of use and manufacture |
US8335551B2 (en) | 2008-09-29 | 2012-12-18 | Chong Il Lee | Method and means for connecting a large number of electrodes to a measuring device |
CN102186532A (zh) | 2008-10-15 | 2011-09-14 | 皇家飞利浦电子股份有限公司 | 用于可植入的电刺激设备的探针 |
EP2349457B1 (en) | 2008-10-15 | 2014-06-25 | Sapiens Steering Brain Stimulation B.V. | Probe for an implantable medical device |
WO2010056535A1 (en) | 2008-10-29 | 2010-05-20 | Cook Biotech Incorporated | Vascular plugs |
JP2012507332A (ja) | 2008-11-05 | 2012-03-29 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 頭蓋移植に関するデバイス及びシステム及びこれらの使用 |
EP2355719B1 (en) | 2008-11-12 | 2015-05-13 | Sapiens Steering Brain Stimulation B.V. | Neurosurgical guiding tool |
MY153794A (en) | 2008-11-13 | 2015-03-31 | Proteus Digital Health Inc | Ingestible therapy activator system and method |
WO2010057063A2 (en) | 2008-11-13 | 2010-05-20 | Proteus Biomedical, Inc. | Pacing and stimulation system, device and method |
EP2355891A1 (en) | 2008-11-13 | 2011-08-17 | Koninklijke Philips Electronics N.V. | Spiraled wires in a deep-brain stimulator probe |
JP2012508611A (ja) | 2008-11-13 | 2012-04-12 | プロテウス バイオメディカル インコーポレイテッド | 遮蔽された刺激および検出のシステムならびに方法 |
US7974705B2 (en) | 2008-11-13 | 2011-07-05 | Proteus Biomedical, Inc. | Multiplexed multi-electrode neurostimulation devices |
CN102215905A (zh) | 2008-11-14 | 2011-10-12 | 皇家飞利浦电子股份有限公司 | 可植入医疗系统 |
US20110196454A1 (en) | 2008-11-18 | 2011-08-11 | Proteus Biomedical, Inc. | Sensing system, device, and method for therapy modulation |
US8386007B2 (en) | 2008-11-21 | 2013-02-26 | Wisconsin Alumni Research Foundation | Thin-film micro electrode array and method |
EP2358275A2 (en) | 2008-12-02 | 2011-08-24 | Proteus Biomedical, Inc. | Optimial drive frequency selection in electrical tomography |
EP2358270A4 (en) | 2008-12-11 | 2014-08-13 | Proteus Digital Health Inc | EVALUATION OF STOMACH DARM FUNCTIONS USING PORTABLE ELECTRIC VISCEROGRAPHY SYSTEMS AND METHOD OF USE THEREOF |
TWI424832B (zh) | 2008-12-15 | 2014-02-01 | Proteus Digital Health Inc | 與身體有關的接收器及其方法 |
US8849369B2 (en) | 2009-01-15 | 2014-09-30 | Eic Laboratories | Wireless recording and stimulation of brain activity |
US8374703B2 (en) | 2009-01-26 | 2013-02-12 | Incube Labs, Llc | Method and apparatus for the detection of aberrant neural-electric activity |
EP2393551A4 (en) | 2009-02-09 | 2013-04-17 | Proteus Digital Health Inc | MULTIPLEX AND MULTILECTRODE NEUROSTIMULATION DEVICES WITH AN INTEGRATED CIRCUIT WITH INTEGRATED ELECTRODES |
JP2012520157A (ja) | 2009-03-13 | 2012-09-06 | プロテウス バイオメディカル インコーポレイテッド | 容積検知 |
US8957207B2 (en) | 2009-03-24 | 2015-02-17 | Proteus S.A. | Methods for producing phycotoxins |
EP2419168B1 (en) | 2009-04-16 | 2019-02-20 | Boston Scientific Neuromodulation Corporation | Deep brain stimulation current steering with split electrodes |
CN102427850A (zh) | 2009-04-23 | 2012-04-25 | 沙皮恩斯脑部刺激控制有限公司 | 包括用于植入在身体部分中的盒的系统 |
SG175388A1 (en) | 2009-04-28 | 2011-12-29 | Proteus Biomedical Inc | Highly reliable ingestible event markers and methods for using the same |
EP2424588A4 (en) | 2009-04-29 | 2013-05-22 | Proteus Digital Health Inc | METHOD AND DEVICE FOR CIRCUITS FOR IMPLANTABLE DEVICES |
WO2010148376A1 (en) | 2009-06-19 | 2010-12-23 | Medtronic, Inc. | Helical electrode arrangements for medical leads |
US8509920B2 (en) | 2009-06-19 | 2013-08-13 | Medtronic, Inc. | Electrode arrangements for medical lead |
WO2011000791A1 (en) | 2009-06-29 | 2011-01-06 | 3Win N.V. | Atraumatic lead for deep brain stimulation |
US8875391B2 (en) | 2009-07-07 | 2014-11-04 | Boston Scientific Neuromodulation Corporation | Methods for making leads with radially-aligned segmented electrodes for electrical stimulation systems |
CN102470240B (zh) | 2009-07-24 | 2015-09-09 | 沙皮恩斯脑部刺激控制有限公司 | 用于电刺激的医疗设备 |
US9119543B2 (en) | 2009-07-30 | 2015-09-01 | Medtronic Bakken Research Center B.V. | System and method for deep brain stimulation |
US20110034970A1 (en) | 2009-08-04 | 2011-02-10 | Boston Scientific Neuromodulation Corporation | Neurostimulation lead and system and methods of making and using |
US9061134B2 (en) | 2009-09-23 | 2015-06-23 | Ripple Llc | Systems and methods for flexible electrodes |
US8171621B2 (en) | 2009-09-30 | 2012-05-08 | Advanced Neuromodulation Systems, Inc. | Methods of fabrication of a simulation lead |
US8435079B1 (en) | 2009-10-01 | 2013-05-07 | Pmt Corporation | Electrode for recording and stimulation |
US8190250B2 (en) | 2009-10-15 | 2012-05-29 | Boston Scientific Neuromodulation Corporation | System and method for estimating volume of activation in tissue |
KR101704851B1 (ko) | 2009-10-16 | 2017-02-08 | 메드트로닉 바켄 리서치 센터, 비.브이. | 신경 인터페이스 시스템 |
US8774891B1 (en) | 2009-11-16 | 2014-07-08 | Pmt Corporation | Cortical electrode assemblies |
US8261428B2 (en) | 2009-11-25 | 2012-09-11 | National Tsing Hua University | Method for assembling a 3-dimensional microelectrode structure |
US8788063B2 (en) | 2009-11-30 | 2014-07-22 | Boston Scientific Neuromodulation Corporation | Electrode array having a rail system and methods of manufacturing the same |
WO2011066552A2 (en) | 2009-11-30 | 2011-06-03 | University Of South Florida | Cubic silicon carbide implantable neural prosthetic |
US8295944B2 (en) | 2009-11-30 | 2012-10-23 | Boston Scientific Neuromodulation Corporation | Electrode array with electrodes having cutout portions and methods of making the same |
US8874232B2 (en) | 2009-11-30 | 2014-10-28 | Boston Scientific Neuromodulation Corporation | Electrode array having concentric split ring electrodes and methods of making the same |
US8583253B1 (en) | 2009-12-17 | 2013-11-12 | Advanced Neuromodulation Systems, Inc. | Implantable neurostimulation system and method for estimating electrode impedance values for neurostimulation systems |
WO2011077368A1 (en) | 2009-12-23 | 2011-06-30 | Koninklijke Philips Electronics N.V. | High resolution electrical stimulation leads |
US8463398B2 (en) | 2009-12-30 | 2013-06-11 | Cardiac Pacemakers, Inc. | Electrode surface modification for imparting current density directionality in lead electrodes |
US20120303088A1 (en) | 2010-01-26 | 2012-11-29 | Sapiens Steering Brain Stimulation B.V. | System and A Method for Determination of an Orientation of a Biomedical Stimulation Device |
WO2011092614A1 (en) | 2010-01-27 | 2011-08-04 | Koninklijke Philips Electronics N.V. | System for medical stimulation comprising a probe |
US8903510B2 (en) | 2010-01-28 | 2014-12-02 | Pacesetter, Inc. | Electrode configurations for leads or catheters to enhance localization using a localization system |
SG182824A1 (en) | 2010-02-01 | 2012-09-27 | Proteus Biomedical Inc | Two-wrist data gathering system |
EP2533851B1 (en) | 2010-02-12 | 2017-08-30 | Medtronic Bakken Research Center B.V. | System for determining settings for deep brain stimulation |
EP2542303B1 (en) | 2010-03-01 | 2017-04-05 | Medtronic Bakken Research Center B.V. | System for determining settings for deep brain stimulation |
US8615311B2 (en) | 2010-03-15 | 2013-12-24 | Rutgers, The State University Of New Jersey | Microelectorode array, methods for preparing the same and uses thereof |
US8099170B2 (en) | 2010-03-19 | 2012-01-17 | Medtronic, Inc. | Electrical stimulation based on phase response mapping |
EP2550059B1 (en) | 2010-03-23 | 2016-01-06 | Boston Scientific Neuromodulation Corporation | Helical radial spacing of contacts on a cylindrical lead |
US9549708B2 (en) | 2010-04-01 | 2017-01-24 | Ecole Polytechnique Federale De Lausanne | Device for interacting with neurological tissue and methods of making and using the same |
BR112012025650A2 (pt) | 2010-04-07 | 2020-08-18 | Proteus Digital Health, Inc. | dispositivo ingerível miniatura |
WO2011128809A2 (en) | 2010-04-12 | 2011-10-20 | Sapiens Steering Brain Stimulation B.V. | Control circuitry and method for controlling a bi-directional switch system, a bi-directional switch, a switching matrix and a medical stimulator |
US8968331B1 (en) | 2010-04-24 | 2015-03-03 | Jerzy Roman Sochor | Implantable lead and surgical accessories |
EP2389975B1 (de) | 2010-05-26 | 2012-08-22 | Marc Prof. Dr. Possover | Implantierbare Sammelelektrode sowie Neurostimulationssystem |
WO2012015756A2 (en) | 2010-07-29 | 2012-02-02 | Proteus Biomedical, Inc. | Hybrid housing for implantable medical device |
US8798764B2 (en) | 2010-09-01 | 2014-08-05 | Medtronic, Inc. | Symmetrical physiological signal sensing with a medical device |
EP2618889B1 (en) | 2010-09-21 | 2014-07-23 | Boston Scientific Neuromodulation Corporation | Systems and methods for making and using radially-aligned segmented electrodes for leads of electrical stimulation systems |
CN103167893A (zh) | 2010-10-29 | 2013-06-19 | 沙皮恩斯脑部刺激控制有限公司 | 神经刺激治疗的计划系统 |
WO2012056039A1 (en) | 2010-10-29 | 2012-05-03 | Sapiens Steering Brain Stimulation B.V. | Multi-electrode neurostimulation device |
WO2012061420A2 (en) | 2010-11-04 | 2012-05-10 | Proteus Biomedical, Inc. | Networked application with a physiological detector |
CN103221090A (zh) | 2010-11-25 | 2013-07-24 | 沙皮恩斯脑部刺激控制有限公司 | 医疗探针以及提供医疗探针的方法 |
CN201871104U (zh) | 2010-11-26 | 2011-06-22 | 上海市第一人民医院 | 微透析探针经皮穿刺定向置入装置及其微透析探针 |
CA2822343A1 (en) | 2010-12-23 | 2012-06-28 | Boston Scientific Neuromodulation Corporation | Methods for making leads with segmented electrodes for electrical stimulation systems |
WO2012095529A1 (en) | 2011-01-14 | 2012-07-19 | Sapiens Steering Brain Stimulation B.V. | Brain mapping probe |
EP2673043B1 (en) | 2011-02-08 | 2015-08-19 | Boston Scientific Neuromodulation Corporation | Leads with segmented electrodes for electrical stimulation systems |
US20120203316A1 (en) | 2011-02-08 | 2012-08-09 | Boston Scientific Neuromodulation Corporation | Leads with segmented electrodes for electrical stimulation of planar regions and methods of making and using |
EP3498333B1 (en) | 2011-02-08 | 2020-05-13 | Boston Scientific Neuromodulation Corporation | Leads with spirally arranged segmented electrodes and methods of making and using the leads |
JP2014508600A (ja) | 2011-02-24 | 2014-04-10 | ボストン サイエンティフィック ニューロモデュレイション コーポレイション | 回路基板及びコネクタを備えた埋込み可能な神経刺激器 |
JP2012179333A (ja) | 2011-02-28 | 2012-09-20 | Ishikawa Toshie | 電極 |
EP2683439B1 (en) | 2011-03-09 | 2019-12-18 | NeuroNexus Technologies, Inc. | Neural interface system with an edge array |
US9220897B2 (en) | 2011-04-04 | 2015-12-29 | Micron Devices Llc | Implantable lead |
US8965499B2 (en) * | 2011-04-29 | 2015-02-24 | Cyberonics, Inc. | Overwrap for nerve stimulation system |
CN102274074A (zh) | 2011-05-03 | 2011-12-14 | 上海微创电生理医疗科技有限公司 | 多极开放式射频消融导管 |
WO2012154865A2 (en) | 2011-05-09 | 2012-11-15 | Setpoint Medical Corporation | Single-pulse activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation |
EP3925662B1 (en) | 2011-05-13 | 2022-12-07 | Saluda Medical Pty Ltd | Implantable device for controlling a neural stimulus |
US10137303B2 (en) | 2011-05-16 | 2018-11-27 | Second Sight Medical Products, Inc. | Cortical interface for motor signal recording and sensory signal stimulation |
US9592389B2 (en) | 2011-05-27 | 2017-03-14 | Boston Scientific Neuromodulation Corporation | Visualization of relevant stimulation leadwire electrodes relative to selected stimulation information |
US9643015B2 (en) | 2011-05-27 | 2017-05-09 | Boston Scientific Neuromodilation Corporation | Collection of clinical data for graphical representation and analysis |
EP2713863B1 (en) | 2011-06-03 | 2020-01-15 | The Board of Trustees of the University of Illionis | Conformable actively multiplexed high-density surface electrode array for brain interfacing |
US9265465B2 (en) | 2011-06-04 | 2016-02-23 | The Regents Of The University Of Michigan | Probes having deployable sites and methods for making the same |
EP2717961B1 (en) | 2011-06-07 | 2017-10-04 | Boston Scientific Neuromodulation Corporation | Systems and methods for making and using improved leads for electrical stimulation systems |
WO2013014206A1 (en) | 2011-07-25 | 2013-01-31 | Imec | Method and device for stimulation/recording of cells |
WO2013018088A1 (en) | 2011-08-04 | 2013-02-07 | Ramot At Tel-Aviv University Ltd | Il-1 receptor antagonist-coated electrode and uses thereof |
WO2013062859A1 (en) | 2011-10-28 | 2013-05-02 | Medtronic, Inc. | Modular lead end |
US9079013B2 (en) | 2011-11-02 | 2015-07-14 | Boston Scientific Neuromodulation Corporation | Methods for making and using improved leads with pre-formed relief sections |
US9095267B2 (en) | 2011-12-22 | 2015-08-04 | Modular Bionics Inc. | Neural interface device and insertion tools |
US8958890B2 (en) | 2012-01-17 | 2015-02-17 | Neuronexus Technologies, Inc. | Implantable neural interface device with a deformable carrier |
EP2620179A1 (en) | 2012-01-24 | 2013-07-31 | Sapiens Steering Brain Stimulation B.V. | Device for planning a neuromodulation therapy |
US8831742B2 (en) | 2012-01-26 | 2014-09-09 | Boston Scientific Neuromodulation Corporation | Systems and methods for identifying the circumferential positioning of electrodes of leads for electrical stimulation systems |
EP2623154A1 (en) | 2012-02-06 | 2013-08-07 | Sapiens Steering Brain Stimulation B.V. | Neurostimulation System |
EP2626111B1 (en) | 2012-02-08 | 2016-08-17 | Medtronic Bakken Research Center B.V. | Medical system and method for planning a neuromodulation therapy |
US9956396B2 (en) | 2012-02-08 | 2018-05-01 | Medtronic Bakken Research Center B.V. | Thin film for a lead for brain applications |
EP2626108A1 (en) | 2012-02-08 | 2013-08-14 | Sapiens Steering Brain Stimulation B.V. | A lead for brain applications |
EP2626109A1 (en) | 2012-02-08 | 2013-08-14 | Sapiens Steering Brain Stimulation B.V. | A probe system for brain applications |
EP2626110A1 (en) | 2012-02-08 | 2013-08-14 | Sapiens Steering Brain Stimulation B.V. | A thin film for a lead for brain applications |
EP2830700B1 (en) | 2012-03-30 | 2017-09-27 | Boston Scientific Neuromodulation Corporation | Leads with x-ray fluorescent capsules for electrode identification and methods of manufacture and use |
US9827413B2 (en) | 2012-04-17 | 2017-11-28 | Boston Scientific Neuromodulation Corporation | Lead construction for deep brain stimulation |
EP2653187A1 (en) | 2012-04-20 | 2013-10-23 | Sapiens Steering Brain Stimulation B.V. | A freestanding thin film, especially a freestanding thin film for a system for neural applications |
EP2656876A1 (en) | 2012-04-25 | 2013-10-30 | Sapiens Steering Brain Stimulation B.V. | A thin film for a lead for neural applications |
EP2656875A1 (en) | 2012-04-25 | 2013-10-30 | Sapiens Steering Brain Stimulation B.V. | Lead for a neurostimulation and/or neurorecording system |
EP2664354B1 (fr) | 2012-05-16 | 2015-09-16 | Sorin CRM SAS | Sonde médicale avec une électrode en forme de bague destinée à être implantée dans un vaisseau cardiaque ou cérébral et un procédé pour sa fabrication |
AU2013267240B2 (en) | 2012-06-01 | 2016-04-28 | Boston Scientific Neuromodulation Corporation | Leads with tip electrode for electrical stimulation systems and methods of making and using |
EP2674193A1 (en) | 2012-06-11 | 2013-12-18 | Sapiens Steering Brain Stimulation B.V. | Synchronization of the operation of an implantable medical device with the application of RF and/or gradient fields in an MRI system |
US9144510B2 (en) | 2012-06-13 | 2015-09-29 | Cook Medical Technologies Llc | Systems and methods for deploying a portion of a stent using at least one coiled member |
US9498617B2 (en) | 2012-06-19 | 2016-11-22 | Lawrence Livermore National Security, Llc | Conformally encapsulated multi-electrode arrays with seamless insulation |
US10245436B2 (en) | 2012-07-17 | 2019-04-02 | Stimwave Technologies Incorporated | Miniature implantable device and methods |
WO2014018092A1 (en) | 2012-07-26 | 2014-01-30 | Medtronic, Inc. | Implantable medical leads |
US8897891B2 (en) | 2012-08-03 | 2014-11-25 | Boston Scientific Neuromodulation Corporation | Leads with electrode carrier for segmented electrodes and methods of making and using |
WO2014036081A1 (en) | 2012-08-28 | 2014-03-06 | Boston Scientific Neuromodulation Corporation | Capture and visualization of clinical effects data in relation to a lead and/or locus of stimulation |
EP2722071A1 (en) | 2012-10-16 | 2014-04-23 | Sapiens Steering Brain Stimulation B.V. | A probe, especially a probe for neural applications |
WO2014085787A1 (en) | 2012-11-30 | 2014-06-05 | The Regents Of The University Of California | Silicon microsystems for high-throughput analysis of neural circuit activity, method and process for making the same |
EP2742968A1 (en) | 2012-12-13 | 2014-06-18 | Sapiens Steering Brain Stimulation B.V. | A probe, especially a probe for neural applications |
AU2014227964B2 (en) | 2013-03-15 | 2016-12-15 | Boston Scientific Neuromodulation Corporation | Clinical response data mapping |
US9399128B2 (en) | 2013-03-16 | 2016-07-26 | Lawrence Livermore National Security, Llc | Flexible neural interfaces with integrated stiffening shank |
CA2910967A1 (en) | 2013-05-15 | 2014-11-20 | Boston Scientific Neuromodulation Corporation | Systems and methods for making and using tip electrodes for leads of electrical stimulation systems |
CN105263567A (zh) | 2013-05-31 | 2016-01-20 | 波士顿科学神经调制公司 | 由具有对准特征的制备电极形成的分段电极引导件以及制造与使用此引导件的方法 |
AU2014274412A1 (en) | 2013-05-31 | 2015-11-19 | Boston Scientific Neuromodulation Corporation | Segmented electrode leads formed from pre-electrodes with depressions or apertures and methods of making |
JP2016519986A (ja) | 2013-05-31 | 2016-07-11 | ボストン サイエンティフィック ニューロモデュレイション コーポレイション | セグメント電極を備えたリード及びリードの製造方法 |
AU2014274416B2 (en) | 2013-05-31 | 2017-01-19 | Boston Scientific Neuromodulation Corporation | Leads containing segmented electrodes with non-perpendicular legs and methods of making and using |
KR101445148B1 (ko) | 2013-06-04 | 2014-10-01 | 주식회사 이노테라피 | 생체 이식형 전극 어셈블리 |
JP6072986B2 (ja) | 2013-07-12 | 2017-02-01 | ボストン サイエンティフィック ニューロモデュレイション コーポレイション | セグメント電極を備えたリード並びにリードの製造及び使用方法 |
US9839777B2 (en) | 2013-08-14 | 2017-12-12 | Syntilla Medical LLC | Implantable neurostimulation lead for head pain |
US9427566B2 (en) | 2013-08-14 | 2016-08-30 | Syntilla Medical LLC | Implantable neurostimulation lead for head pain |
WO2015031375A1 (en) | 2013-08-30 | 2015-03-05 | Boston Scientific Neuromodulation Corporation | Methods of making segmented electrode leads using flanged carrier |
CN105636537B (zh) | 2013-10-15 | 2018-08-17 | 波士顿科学国际有限公司 | 医疗器械球囊 |
US10118030B2 (en) | 2013-10-21 | 2018-11-06 | Neuronexus Technologies, Inc. | Omnidirectional deployable multichannel neural electrode system |
US9775988B2 (en) | 2013-12-02 | 2017-10-03 | Boston Scientific Neuromodulation Corporation | Electrical stimulation leads with helically arranged electrodes and methods of making and using |
US9457188B2 (en) | 2014-03-03 | 2016-10-04 | Medtronic, Inc. | Therapeutic window determination |
WO2015143443A1 (en) | 2014-03-21 | 2015-09-24 | University Of Utah Research Foundation | Multi-site electrode arrays and methods of making the same |
WO2015164340A1 (en) | 2014-04-21 | 2015-10-29 | University Of South Florida | Magnetic resonant imaging safe stylus |
DK3139999T3 (da) | 2014-05-05 | 2020-06-22 | Saluda Medical Pty Ltd | Forbedret neutral måling |
EP2946806B1 (fr) | 2014-05-19 | 2016-07-27 | Sorin CRM SAS | Dispositif médical implantable actif à optimisation automatique de la configuration d'une sonde de stimulation multi-électrode, notamment d'une sonde de stimulation sélective du nerf vague |
US20150355413A1 (en) | 2014-06-04 | 2015-12-10 | Corning Incorporated | Integrated torque jacket systems and methods for oct |
JP2017517374A (ja) | 2014-06-13 | 2017-06-29 | ボストン サイエンティフィック ニューロモデュレイション コーポレイション | セグメント電極のための電極担体を有するリード及びそれを製造する方法及び使用する方法 |
US9861288B2 (en) | 2014-07-11 | 2018-01-09 | Wisconsin Alumni Research Foundation | Transparent and flexible neural electrode arrays |
CN204092843U (zh) | 2014-09-30 | 2015-01-14 | 苏州景昱医疗器械有限公司 | 脑深部刺激电极及装置 |
US9498628B2 (en) | 2014-11-21 | 2016-11-22 | Medtronic, Inc. | Electrode selection for electrical stimulation therapy |
EP4285985A3 (en) | 2014-12-11 | 2024-01-17 | Saluda Medical Pty Ltd | Method and device for feedback control of neural stimulation |
US9849287B2 (en) | 2015-02-09 | 2017-12-26 | Boston Scientific Neuromodulation Corporation | System and method for determining the neurological position of epidural leads |
US9833611B2 (en) | 2015-04-10 | 2017-12-05 | Boston Scientific Neuromodulation Corporation | Systems and methods for making and using improved contact arrays for electrical stimulation systems |
US9364659B1 (en) | 2015-04-27 | 2016-06-14 | Dantam K. Rao | Smart lead for deep brain stimulation |
US20160361535A1 (en) | 2015-06-11 | 2016-12-15 | Micron Devices Llc | Embedded fixation devices or leads |
EP3111835B1 (en) | 2015-06-30 | 2020-06-03 | IMEC vzw | Sensing device with array of microelectrodes |
WO2017035530A1 (en) | 2015-08-27 | 2017-03-02 | The Trustees Of Columbia University In The City Of New York | Flexible complementary metal-oxide-semiconductor probes for chronic, large-scale neural stimulation and recording |
CN114082104A (zh) | 2016-01-12 | 2022-02-25 | 波士顿科学神经调制公司 | 可植入设备编程管理 |
CN109069824B (zh) | 2016-02-02 | 2022-09-16 | 阿莱瓦神经治疗股份有限公司 | 使用深部脑刺激治疗自身免疫疾病 |
GB201609377D0 (en) | 2016-05-27 | 2016-07-13 | Isis Innovation | Operation of a deep brain stimulation (DBS) lead |
WO2018068013A1 (en) | 2016-10-06 | 2018-04-12 | The Regents Of The University Of California | An implantable electrocorticogram brain-computer interface system for restoring extremity movement |
WO2018102773A1 (en) | 2016-12-02 | 2018-06-07 | Boston Scientific Neuromodulation Corporation | Methods and systems for selecting stimulation parameters for electrical stimulation devices |
US10905887B2 (en) | 2017-03-27 | 2021-02-02 | Boston Scientific Neuromodulation Corporation | Method and apparatus for clinical effects-based targeting of neurostimulation |
-
2018
- 2018-03-02 US US15/910,278 patent/US10702692B2/en active Active
-
2019
- 2019-02-28 EP EP21207327.4A patent/EP3970788A1/en active Pending
- 2019-02-28 EP EP19713581.7A patent/EP3758792B1/en active Active
- 2019-02-28 CN CN201980015093.6A patent/CN111801136A/zh active Pending
- 2019-02-28 WO PCT/IB2019/051635 patent/WO2019166994A1/en active Application Filing
-
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- 2020-06-15 US US16/901,583 patent/US11266830B2/en active Active
-
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- 2022-02-08 US US17/667,052 patent/US11738192B2/en active Active
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5125150A (en) * | 1991-09-03 | 1992-06-30 | Amp Incorporated | Tool for mass terminating wires to electrical connectors |
CN101970041A (zh) * | 2007-11-16 | 2011-02-09 | 耳蜗有限公司 | 电极阵列以及形成电极阵列的方法 |
US20110301665A1 (en) * | 2008-11-12 | 2011-12-08 | Ecole Polytechnique Federale De Lausanne | Microfabricated neurostimulation device |
US20110047795A1 (en) * | 2009-09-01 | 2011-03-03 | Kevin Turner | Medical leads with segmented electrodes and methods of fabrication thereof |
CN103415317A (zh) * | 2011-02-17 | 2013-11-27 | 先进仿生学股份公司 | 线构造 |
US20130261489A1 (en) * | 2012-03-29 | 2013-10-03 | Ad-Tech Medical Instrument Corp. | Intracranial sensing & monitoring device with macro and micro electrodes |
US20160059004A1 (en) * | 2014-08-27 | 2016-03-03 | Aleva Neurotherapeutics | Deep brain stimulation lead |
US20160059016A1 (en) * | 2014-08-27 | 2016-03-03 | Aleva Neurotherapeutics | Leadless neurostimulator |
CN106456966A (zh) * | 2014-08-27 | 2017-02-22 | 阿莱瓦神经治疗股份有限公司 | 大脑深度刺激导针 |
US20170312494A1 (en) * | 2016-04-28 | 2017-11-02 | Medtronic, Inc. | Lead implant fixation mechanism |
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US11738192B2 (en) | 2023-08-29 |
EP3758792A1 (en) | 2021-01-06 |
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US11266830B2 (en) | 2022-03-08 |
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