CN111774116A - Reagent supply device for micro-fluidic detection - Google Patents
Reagent supply device for micro-fluidic detection Download PDFInfo
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- CN111774116A CN111774116A CN202010791301.6A CN202010791301A CN111774116A CN 111774116 A CN111774116 A CN 111774116A CN 202010791301 A CN202010791301 A CN 202010791301A CN 111774116 A CN111774116 A CN 111774116A
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- 239000003153 chemical reaction reagent Substances 0.000 title claims abstract description 118
- 238000001514 detection method Methods 0.000 title claims abstract description 30
- 239000004809 Teflon Substances 0.000 claims abstract description 33
- 229920006362 Teflon® Polymers 0.000 claims abstract description 33
- 229910001220 stainless steel Inorganic materials 0.000 claims abstract description 26
- 239000010935 stainless steel Substances 0.000 claims abstract description 26
- 238000009434 installation Methods 0.000 claims description 38
- 239000011324 bead Substances 0.000 claims description 14
- 230000000149 penetrating effect Effects 0.000 claims description 3
- 229910000831 Steel Inorganic materials 0.000 claims description 2
- 230000009471 action Effects 0.000 claims description 2
- 239000010959 steel Substances 0.000 claims description 2
- 230000007704 transition Effects 0.000 claims 8
- 238000011160 research Methods 0.000 description 5
- 230000008878 coupling Effects 0.000 description 4
- 238000010168 coupling process Methods 0.000 description 4
- 238000005859 coupling reaction Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 210000003205 muscle Anatomy 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 2
- 230000002079 cooperative effect Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000001174 ascending effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- -1 electronics Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
Abstract
The invention relates to the technical field of microfluidics, in particular to a reagent supply device for microfluidic detection, which comprises a cover plate, a support, a stainless steel pipe, a reagent bottle seat, a reagent bottle, an adjusting seat, a Teflon pipe, a movable plate and a lead screw stepping motor, wherein a Teflon pipe groove is fixedly arranged at the upper part of the support.
Description
Technical Field
The invention relates to the technical field of microfluidics, in particular to a reagent supply device for microfluidic detection.
Background
The microfluidic technology is a technology for precisely controlling and controlling microscale fluid, that is, a technology for automatically completing the whole analysis process by integrating basic operation units of sample preparation, reaction, separation, detection and the like in the biological, chemical and medical analysis processes on a microfluidic chip with a few square centimeters, and has been developed into a brand-new research field crossing the disciplines of biology, chemistry, medicine, fluid, electronics, materials, machinery and the like due to the great potential in the fields of biology, chemistry, medicine and the like.
At present, the research of microfluidic detection focuses on the research and development of chips and the research of devices (such as control valves, magnetic bead control devices, heating devices, and the like) in direct contact with the chips, the research on reagent supply devices for microfluidic is less, some automatic supply systems are also rough, and can only meet the test requirements at most, the process of replacing reagents is particularly troublesome, and cannot meet the supply requirements of reagent bottles with different specifications and capacities and reagents with different quantities, so that the research, development and use of microfluidic detection equipment are seriously influenced. In a specific operation, the premise for realizing the automatic microfluidic detection device is to have a reliable reagent supply device, so that a reliable microfluidic reagent supply device for operation is urgently needed.
Disclosure of Invention
The invention aims to provide a reagent supply device for microfluidic detection, which can quickly and conveniently replace a reagent, has small occupied space, simple and reliable movement and convenient connection with a quantitative pump, can meet the supply requirements of reagent bottles with different specifications and capacities and reagents with different quantities, and has better compatibility with different microfluidic detection equipment.
In order to achieve the purpose, the invention adopts the following technical scheme:
a reagent feeding device for microfluidic detection comprises a cover plate, a support, a stainless steel pipe, a reagent bottle seat, a reagent bottle, an adjusting seat, a Teflon pipe, a movable plate and a lead screw stepping motor, wherein a Teflon pipe groove is fixedly arranged on the upper portion of the support, the Teflon pipe for an external constant delivery pump is arranged in the Teflon pipe groove, the cover plate is arranged on the upper portion of the Teflon pipe groove on the upper portion of the support and tightly presses the Teflon pipe in the Teflon pipe groove, the lower portion of the Teflon pipe is connected with the stainless steel pipe, a lead screw stepping motor mounting plate is fixedly arranged on the lower portion of the support, the lead screw stepping motor is arranged on the lead screw stepping motor mounting plate, a lead screw is arranged at the power output end of the lead screw stepping motor, a lead screw support is fixedly arranged on the support, the other end of the lead screw is arranged on the lead screw support, a sliding groove for installing the reagent bottle seat is arranged on the support, the reagent bottle seat install the spout position on the support, the movable plate that is used for driving mobile reagent bottle seat and reciprocates install on the lead screw and link to each other with lead screw thread fit, mobile reagent bottle seat pass through the bolt and install on the movable plate, reagent bottle seat be semi-open cell type structure, install the regulation seat that is used for adjusting reagent bottle installation specification in the cell type structure on reagent bottle seat, the regulation seat can play the fixed action to reagent bottle seat, the lower part installation setting of nonrust steel pipe is in the reagent bottle.
The reagent bottle seat consists of a support plate, a transitional connection driving installation frame and a top plate, the support plate is arranged at the lower part of the transitional connection driving installation frame and is fixedly connected with the transitional connection driving installation frame, the top plate is arranged at the upper part of the transitional connection driving installation frame and is fixedly connected with the transitional connection driving installation frame, a semi-open type installation groove for installing the reagent bottle is arranged in the transitional connection driving installation frame, a positioning plate for clamping the reagent bottle is fixedly arranged on the top plate at the upper part of the semi-open type installation groove, a stainless steel pipe guide hole for penetrating and installing a stainless steel pipe is processed on the top plate between the positioning plates, a guide post is fixedly arranged on the back surface of the transitional connection driving installation frame, the guide post can penetrate through a sliding groove formed in the support and is arranged on the movable plate, and a positioning hole is formed in the lower part of the, arc grooves for conveniently taking out articles in the semi-open mounting grooves are formed in two side walls of the transitional connection driving mounting frame, and clamping grooves for mounting the adjusting seat are formed in the upper and lower parts of the arc grooves.
The regulation seat constitute by adjusting seat body, cardboard and spacing muscle, the regulation seat this internal open logical groove in upper and lower end that is used for the reagent bottle installation, fixed mounting has the spacing muscle that is used for the tight spacing of reagent bottle card on the regulation seat body that leads to the groove both sides, has the cardboard in the outside both sides fixed mounting who adjusts the seat body, adjust the seat body and can install on the draw-in groove that transitional coupling drove the installing frame and then make the regulation seat can install in the reagent bottle seat through the cardboard.
The movable plate include erection joint board, thread bush and curb plate, the thread bush on seted up the internal thread hole, the thread bush pass through the internal thread hole and install on the lead screw and link to each other with lead screw thread fit, thread bush fixed mounting on the erection joint board, the erection joint board on fixed mounting have the curb plate that is used for touching limit switch.
The upper part of the support is fixedly provided with a cover plate mounting hole, and the cover plate is arranged on the support through the cover plate mounting hole.
The support is fixedly provided with a support mounting hole and is arranged on the microfluidic detection equipment through the support mounting hole.
The upper portion of the support is provided with a limit switch mounting seat, and the limit switch mounting seat is provided with a limit switch used for limiting the moving plate.
The support on still fixed mounting have a location pearl mounting hole, the location pearl mounting hole in install and be used for guaranteeing the location pearl of reagent bottle operating position reliability.
The invention has the beneficial effects that: the reagent feeding device for the microfluidic detection provided by the invention has the advantages that the overall structural design is very scientific, the installation and the use are convenient, the reagent bottle for containing the reagent can be conveniently and quickly replaced mainly through the cooperative action of the structural elements such as the reagent bottle seat, the adjusting seat, the moving plate, the lead screw stepping motor and the like, the overall occupied space of the device is small, the overall movement of the structure is simple and reliable, the device is conveniently connected with a dosing pump, the device can meet the feeding requirements of reagent bottles with different specifications and capacities and reagents with different quantities, and the device has better compatibility with different microfluidic detection equipment.
Drawings
FIG. 1 is a first schematic view of the installation structure of the present invention;
FIG. 2 is a second schematic view of the overall installation structure of the present invention;
FIG. 3 is a first schematic structural view of a support in the present invention;
FIG. 4 is a second schematic structural view of the stand of the present invention;
FIG. 5 is a first schematic view of a reagent bottle holder according to the present invention;
FIG. 6 is a second schematic structural view of a reagent bottle holder according to the present invention;
FIG. 7 is a schematic view of the structure of the adjustment seat of the present invention;
FIG. 8 is a first schematic view of reagent bottle mounting structures of different specifications;
FIG. 9 is a second schematic view of a reagent bottle mounting structure of different specifications;
FIG. 10 is a schematic view of the adjusting seat of the present invention installed in the reagent bottle seat;
FIG. 11 is a schematic view showing the structure of a reagent bottle according to the present invention;
FIG. 12 is a schematic view of the structure of the moving plate of the present invention;
the reference numbers in the figures are: 1-cover plate, 2-support, 3-stainless steel tube, 4-reagent bottle seat, 5-reagent bottle, 6-adjusting seat, 7-Teflon tube, 8-limit switch, 9-positioning bead, 10-moving plate, 11-lead screw stepping motor, 12-lead screw, 201-cover plate mounting hole, 202-support mounting hole, 203-sliding groove, 204-positioning bead mounting hole, 205-Teflon tube groove, 206-lead screw support, 207-limit switch mounting seat, 208-lead screw stepping motor mounting plate, 401-stainless steel tube guide hole, 402-guide column, 403-clamping groove, 404-positioning plate, 405-positioning hole, 406-arc groove, 407-top plate, 408-transition connection driving mounting frame, 409-a supporting plate, 410-a semi-open type mounting groove, 601-a clamping plate, 602-a limiting rib, 603-an adjusting seat body, 604-a through groove, 1001-an internal threaded hole, 1002-a side plate, 1003-a threaded sleeve and 1004-an installation connecting plate.
Detailed Description
Specific example 1: the core of the invention is to provide a reagent feeding device for microfluidic detection, which can conveniently and quickly replace a reagent bottle 5 containing a reagent mainly through the cooperative action of structural elements such as a reagent bottle seat 4, an adjusting seat 6, a moving plate 10, a lead screw stepping motor 11 and the like, and in order to enable a person in the technical field to better understand the technical scheme of the invention, the invention is further described in detail below by combining the drawings and the specific implementation mode of the specification, and it needs to be described that when an element is called to be fixed on or arranged on another element, the element can be directly or indirectly connected to the other element. When an element is referred to as being "connected to" another element, it can be directly or indirectly connected to the other element. The terms "left" and "right" used in this specification to denote orientation are used with reference to a particular structure shown in the drawings, and do not constitute a limitation on the structure. As shown in the attached fig. 1-12 of the specification, a reagent feeding device for microfluidic detection mainly comprises a cover plate 1, a support 2, a stainless steel tube 3, a reagent bottle seat 4, a reagent bottle 5, an adjusting seat 6, a teflon tube 7, a moving plate 10 and a lead screw stepping motor 11, wherein a cover plate mounting hole 201 is fixedly mounted on the upper portion of the support 2, the cover plate 1 is mounted on the support 2 through the cover plate mounting hole 201, a teflon tube groove 205 is fixedly arranged on the upper portion of the support 2, the teflon tube 7 for externally connecting a quantitative pump is mounted in the teflon tube groove 205, the cover plate 1 is mounted on the upper portion of the teflon tube groove 205 on the upper portion of the support 2 and tightly presses the teflon tube 7 in the teflon tube groove 205, the lower portion of the teflon tube 7 is connected with the stainless steel tube, the lower portion of the stainless steel tube is mounted in the reagent bottle 5, a lead screw stepping motor mounting plate 208 is fixedly arranged on the lower portion of the support 2, the lead screw stepping motor, a screw 12 is arranged at the power output end of a screw stepping motor 11, a screw support 206 is fixedly arranged on a support 2, the other end of the screw 12 is arranged on the screw support 206, a chute 203 for installing a reagent bottle seat 4 is arranged on the support 2, the reagent bottle seat 4 consists of a support plate 409, a transitional connection driving installation frame 408 and a top plate 407, the support plate 409 is fixedly arranged at the lower part of the transitional connection driving installation frame 408, the top plate 407 is fixedly arranged at the upper part of the transitional connection driving installation frame 408, a semi-open type installation groove 410 for installing a reagent bottle 5 is arranged in the transitional connection driving installation frame 408, a positioning plate 404 for clamping the reagent bottle 5 is fixedly arranged on the top plate 407 at the upper part of the semi-open type installation groove 410, a stainless steel pipe guide hole 401 for installing a stainless steel pipe in a penetrating way is processed on the top plate 407 between the positioning plates 404, the stainless steel pipe penetrates through the stainless steel pipe, the back fixed mounting that the transitional coupling drove installing frame 408 has guide post 402, guide post 402 can run through the spout 203 that sets up on the support 2 and install on movable plate 10, locating hole 405 has been seted up in the lower part of guide post 402, set up the arc recess 406 that is used for conveniently taking out article in the semi-open mounting groove 410 on the both sides wall that the transitional coupling drove installing frame 408, the draw-in groove 403 that is used for adjusting the seat installation has been processed at the upper and lower position of arc recess 406, adjust the seat and comprise regulation seat body 603, cardboard 601 and spacing muscle 602, adjust the open logical groove 604 in the upper and lower end for being used for reagent bottle 5 installation in the seat body 603, fixed mounting has the spacing muscle 602 that is used for reagent bottle 5 chucking spacing on the regulation seat body 603 of logical groove 604 both sides, outside both sides fixed mounting has cardboard 601 at regulation seat body 603, it can drive the draw-in the installing frame 403 on the transitional coupling through cardboard 601 and make the regulation seat 6 can install at reagent bottle and drive the In the seat 4, a moving plate 10 for driving the moving reagent bottle seat 4 to move up and down is installed on a screw rod 12, the moving plate 10 comprises an installation connecting plate 1004, a threaded sleeve 1003 and a side plate 1002, an internal threaded hole 1001 is formed in the threaded sleeve 1003, the threaded sleeve 1003 is installed on the screw rod 12 through the internal threaded hole 1001 and is in threaded fit connection with the screw rod 12, the threaded sleeve 1003 is fixedly installed on the installation connecting plate 1004, the installation connecting plate 1004 is connected with a transitional connection driving installation frame 408 through a guide column 402, the side plate 1002 for touching a limit switch 8 is fixedly installed on the installation connecting plate 1004, a support installation hole 202 is fixedly arranged on a support 2, the support 2 is installed on a microfluidic detection device through the support installation hole 202, a limit switch installation seat 207 is further installed on the upper portion of the support 2, the limit switch installation seat 207 is provided with the limit switch 8 for limiting the, the support 2 is also fixedly provided with a positioning bead mounting hole 204, and a positioning bead 9 used for ensuring the reliability of the working position of the reagent bottle 5 is arranged in the positioning bead mounting hole 204. The specific working process of the invention is, as shown in the accompanying drawings 1 and 2 of the specification, placing the reagent bottle 5 in the reagent bottle seat 4, because the specification of the reagent bottle 5 is often required to be adjusted according to the detection requirement (when the reagent dosage is small, and the reagent is difficult to store at room temperature for a long time or test equipment), in order to increase the universality of the microfluidic detection device, the reagent bottle seat 4 is provided with the adjusting seat 6, and the reagent bottle can be placed in the semi-open type mounting groove 410 in the reagent bottle seat 4 according to the detection requirement so as to adapt to the reagent bottles 5 of different specifications (it needs to be further pointed out that the reagent bottles 5 used in the invention have the same height and size and the variable diameters and capacities). The reagent bottle seat 4 is connected with the movable plate 10 and can move along the sliding groove 203 in the support 2, a threaded hole is arranged in the threaded sleeve 1003 in the connecting plate 10 and is matched with the lead screw 12 of the lead screw stepping motor 11, and when the lead screw stepping motor 11 drives the lead screw 12 to rotate, the lead screw 12 can drive the threaded sleeve 1003 to move up and down on the threaded sleeve. The position of the moving plate 10 is controlled by a limit switch 8, the limit switch 8 is arranged on a limit switch mounting seat 207 at the upper part and the lower part of the sliding chute 203, the lower limit switch controls the initial position, and the upper limit switch controls the feeding position. The feeding pipeline consists of a stainless steel pipe 3 and a Teflon pipe 7, one end of the stainless steel pipe 3 is fixed on the support 2, the other end of the stainless steel pipe is arranged in the guide hole of the reagent bottle seat, the stainless steel pipe 3 gradually enters the reagent bottle 5 along with the ascending of the reagent bottle seat 4, and finally the bottom of the stainless steel pipe 3 and the bottom of the reagent bottle 5 are separated by 1-2 mm. One end of the Teflon tube 7 is connected with the stainless steel tube 3, is fixed by the cover plate 1 through the Teflon tube groove 205 on the support 2, and the other end is connected with a quantitative pump (not shown), and is sent to the microfluidic chip through the quantitative pump. The positioning beads 9 are arranged in the positioning bead mounting holes 204, the number of the positioning beads is 2, the positioning beads are matched with the positioning holes 405 (which are hemispheric) on the reagent bottle seat 4, and the reliability of the working positions of the reagent bottles 5 is ensured. In the accompanying drawings 3 and 4 of the specification of the invention, cover plate mounting holes 201 are arranged on the left and right of the top of a support and are connected with a cover plate 1 through screws, support mounting holes 202 are arranged on the four corners of the support to form 4, the support is externally connected with a microfluidic detection device, a sliding groove 203 plays a role in guiding a reagent bottle seat 4 to ensure that a reagent bottle 5 moves up and down, the support is also provided with a positioning ball mounting hole 204 and a limit switch mounting seat 207, the positions of the positioning ball mounting hole and the limit switch mounting seat are arranged according to the specific height of the reagent bottle 5, a Teflon pipe groove 205 is a semicircular groove and has a good guiding and fixing effect on a Teflon pipe 7, a lead screw stepping motor mounting plate 208 is fixed with a lead screw stepping motor 11 through bolts, and a lead screw support 206 supports the tail end of a lead screw 12 to ensure that the lead screw 12 moves stably, such as the accompanying drawings 5, 6, as shown in the attached figures 9 and 10 of the specification, in the figures, a stainless steel pipe 3 enters a reagent bottle 5 through a stainless steel guide hole 401, a guide post 402 is matched with an upper chute 203 of a support 2 and penetrates through the chute 203, a threaded hole is formed in the guide post 402 and is connected with a movable plate 10 through a connecting screw, after the fixing, a reagent bottle seat 4 can only move up and down along the guide chute 203, a clamping groove 403 is matched with a clamping plate 601 on an adjusting seat 6, the adjusting seat 6 is fixed, a positioning plate 404 can clamp the reagent bottle 5 in the vertical height direction, a positioning hole 405 is matched with a positioning bead 9 to play a role in fixing position, when the reagent needs to be taken out and replaced, an operator can take down the reagent bottle 5 or the adjusting seat 6 through an arc-shaped groove 406 formed on two side walls of a transitional connection driving mounting frame 408 by fingers tightly, the convenience and quickness are achieved, as shown in the attached figure 11 of the, this structure can make reagent utilization ratio in the reagent bottle 5 the highest, reduces the residual liquid, as shown in the description figure 12, internal thread hole 1001 on the thread bush 1003 and lead screw 12 cooperation drive movable plate 10 whole and reciprocate along with lead screw 12 rotates, and curb plate 1002 is used for touching limit switch 8 and then reminds the operation user of noticing. The foregoing illustrates and describes the principles, general features, and advantages of the present invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed.
Claims (8)
1. The utility model provides a micro-fluidic detection is with reagent feeding device, its characterized in that includes apron, support, stainless steel pipe, reagent bottle seat, reagent bottle, regulation seat, teflon pipe, movable plate and lead screw step motor, support upper portion fixed be provided with teflon pipe groove for the teflon pipe of external constant delivery pump is installed in teflon pipe groove, the apron install at teflon pipe groove upper portion position on support upper portion and compress tightly teflon pipe in teflon pipe groove, teflon pipe sub-unit connection stainless steel pipe, support lower part fixed be provided with lead screw step motor mounting panel, lead screw step motor install on lead screw step motor mounting panel, install the lead screw at lead screw step motor power take off end, the support on fixed mounting have the lead screw support, another tip of lead screw install on the lead screw support, the reagent bottle seat is installed at the spout position on the support, the movable plate that is used for driving the movable reagent bottle seat to reciprocate is installed on the lead screw and is linked to each other with lead screw thread fit, the movable reagent bottle seat pass through the bolt and install on the movable plate, the reagent bottle seat be semi-open cell type structure, install the regulation seat that is used for adjusting reagent bottle installation specification in the cell type structure on the reagent bottle seat, the regulation seat can play the fixed action to the reagent bottle seat, the lower part installation setting of nonrust steel pipe is in the reagent bottle.
2. The reagent feeding device for microfluidic detection according to claim 1, wherein the reagent bottle seat comprises a supporting plate, a transition connection driving mounting frame and a top plate, the supporting plate is installed at the lower part of the transition connection driving mounting frame and is fixedly connected with the transition connection driving mounting frame, the top plate is installed at the upper part of the transition connection driving mounting frame and is fixedly connected with the transition connection driving mounting frame, a semi-open mounting groove for installing the reagent bottle is formed in the transition connection driving mounting frame, a positioning plate for clamping the reagent bottle is fixedly installed on the top plate at the upper part of the semi-open mounting groove, a stainless steel pipe guide hole for installing the stainless steel pipe in a penetrating manner is processed on the top plate between the positioning plates, a guide post is fixedly installed on the back surface of the transition connection driving mounting frame, and the guide plate can penetrate through a sliding groove formed in the support and is installed on the support, the lower part of the guide post is provided with a positioning hole, the two side walls of the installation frame driven by the transitional connection are provided with arc-shaped grooves for conveniently taking out articles in the semi-open installation groove, and the upper part and the lower part of each arc-shaped groove are provided with clamping grooves for installing the adjusting seat.
3. The reagent feeding device for microfluidic detection according to claim 1, wherein the adjusting seat comprises an adjusting seat body, a clamping plate and a limiting rib, the adjusting seat body is a through groove with open upper and lower ends for installing the reagent bottle, the limiting rib for clamping and limiting the reagent bottle is fixedly installed on the adjusting seat body on two sides of the through groove, the clamping plate is fixedly installed on two outer sides of the adjusting seat body, and the adjusting seat body can be installed on the clamping groove on the transition connection driving installation frame through the clamping plate so that the adjusting seat can be installed in the reagent bottle seat.
4. The reagent feeding device for microfluidic detection according to claim 1, wherein the moving plate comprises a mounting connection plate, a threaded sleeve and a side plate, the threaded sleeve is provided with an internal threaded hole, the threaded sleeve is mounted on the lead screw through the internal threaded hole and is in threaded fit connection with the lead screw, the threaded sleeve is fixedly mounted on the mounting connection plate, and the side plate for touching the limit switch is fixedly mounted on the mounting connection plate.
5. The reagent feeding device for microfluidic detection according to claim 1, wherein a cover plate mounting hole is fixedly installed on the upper portion of the support, and the cover plate is installed on the support through the cover plate mounting hole.
6. The reagent feeding device for microfluidic detection according to claim 1, wherein the holder is fixedly provided with a holder mounting hole, and the holder is mounted on the microfluidic detection apparatus through the holder mounting hole.
7. The reagent feeding device for microfluidic detection according to claim 1, wherein a limit switch mounting seat is mounted on the upper portion of the support, and a limit switch for limiting the moving plate is mounted on the limit switch mounting seat.
8. The reagent feeding device for microfluidic detection according to claim 1, wherein the holder is further fixedly provided with a positioning bead mounting hole, and a positioning bead for ensuring reliability of the working position of the reagent bottle is mounted in the positioning bead mounting hole.
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| CN202010791301.6A CN111774116B (en) | 2020-08-07 | 2020-08-07 | Reagent feeding device for microfluidic detection |
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| CN202010791301.6A CN111774116B (en) | 2020-08-07 | 2020-08-07 | Reagent feeding device for microfluidic detection |
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| CN106269587A (en) * | 2016-08-30 | 2017-01-04 | 福州派利德电子科技有限公司 | IC chip cliff cut style testing, sorting machine automatic collecting device |
| US20190374946A1 (en) * | 2017-02-22 | 2019-12-12 | Kilobaser Gmbh | Device for synthesizing oligonucleotides |
| CN109517732A (en) * | 2017-09-19 | 2019-03-26 | 德诺杰亿（北京）生物科技有限公司 | Integrated DNA analysis system |
| CN208537555U (en) * | 2018-06-07 | 2019-02-22 | 天津康信华诺科技有限公司 | A kind of platelet aggregation detection device |
| CN109603950A (en) * | 2018-11-27 | 2019-04-12 | 迪瑞医疗科技股份有限公司 | A kind of reagent bottle clamp assemblies, autoloading structure and its loading method |
| CN213050679U (en) * | 2020-08-07 | 2021-04-27 | 河南固创生物科技有限公司 | Reagent supply device for micro-fluidic detection |
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