CN109439514A - A kind of support device for array microfluidic point sample microfluidic control device - Google Patents
A kind of support device for array microfluidic point sample microfluidic control device Download PDFInfo
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- CN109439514A CN109439514A CN201811536258.8A CN201811536258A CN109439514A CN 109439514 A CN109439514 A CN 109439514A CN 201811536258 A CN201811536258 A CN 201811536258A CN 109439514 A CN109439514 A CN 109439514A
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- fixed jaw
- movable claw
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- 210000000078 claw Anatomy 0.000 claims abstract description 24
- 239000007788 liquid Substances 0.000 abstract description 17
- 238000010586 diagram Methods 0.000 description 6
- 238000010438 heat treatment Methods 0.000 description 6
- 239000012530 fluid Substances 0.000 description 5
- 239000002699 waste material Substances 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001917 fluorescence detection Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/16—Microfluidic devices; Capillary tubes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/48—Holding appliances; Racks; Supports
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Sustainable Development (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Clinical Laboratory Science (AREA)
- Dispersion Chemistry (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention discloses a kind of support devices for array microfluidic point sample microfluidic control device, including I-shaped connection grillage, the L-type fixed jaw of handstand and the L-type movable claw of handstand, I-shaped connection grillage lower end side is fixedly connected with L-type fixed jaw, bottom is provided with T-type sliding slot, T-type sliding block is installed in T-type sliding slot, T-type sliding block is fixedly connected with L-type movable claw, L-type fixed jaw is connected with L-type movable claw by screw rod spiral, screw thread at L-type fixed jaw and L-type movable claw connection wire rod is reversed, L-type fixed jaw and L-type movable claw lower end inside are embedded into the groove of microfluidic control device two sides.Setting clamping microfluidic control device in downside in structure of the invention, it is conveniently replaceable the Wake control device of different templates, realize different liquid form point samples, using screw rod, fixed jaw and movable claw structure, convenient for rapid-assembling/disassembling, clamping is reliable and stable, conveniently adapts to different size of microfluidic control device, the utilization rate of equipment is improved, equipment cost is reduced.
Description
Technical field
The present invention relates to a kind of support devices for array microfluidic point sample microfluidic control device, belong to microfluid point sample
Equipment technical field.
Background technique
With the research and progress of current biological medicinal career, in order to meet unicellular culture, microcell DNA fluorescence detection,
With biological cell sensing etc., people are to the array for processing miscellaneous shape in different base sample surfaces rapid, high volume
Produce increasing needs.When carrying out batch point sample using the microfluidic control device of array point sample, existing technology is simultaneously
There is not the fixation that can adapt to different size of microfluidic control device.
Summary of the invention
The technical problem to be solved by the present invention is providing a kind of support for array microfluidic point sample microfluidic control device
Device, to solve above-mentioned problems of the prior art.
The technical scheme adopted by the invention is as follows: a kind of support device for array microfluidic point sample microfluidic control device,
Including I-shaped connection grillage, the L-type fixed jaw of handstand and the L-type movable claw of handstand, I-shaped connection grillage lower end side is solid
Surely L-type fixed jaw is connected, bottom is provided with T-type sliding slot, T-type sliding block is equipped in T-type sliding slot, it is living that T-type sliding block is fixedly connected with L-type
Pawl, L-type fixed jaw and L-type movable claw are connected by screw rod spiral, the spiral shell at L-type fixed jaw and L-type movable claw connection wire rod
Line is reversed, and L-type fixed jaw and L-type movable claw lower end inside are embedded into the groove of microfluidic control device two sides.
Beneficial effects of the present invention: compared with prior art, downside setting clamping microfluidic control dress in structure of the invention
Set, be conveniently replaceable the Wake control device of different templates, realize different liquid form point samples, using screw rod, fixed jaw and
Movable claw structure is convenient for rapid-assembling/disassembling, and clamping is reliable and stable, is also convenient for adapting to different size of microfluidic control device, mention significantly
The utilization rate of high equipment reduces equipment cost.
Detailed description of the invention
Fig. 1 is overall structure diagram；
Fig. 2 is microfluidic control device attachment structure schematic diagram；
Fig. 3 is liquid sample introduction device structural schematic diagram；
Fig. 4 is spotting template structural schematic diagram；
Fig. 5 is supporting structure schematic diagram；
Fig. 6 is all directions screw-nut driving mechanism schematic diagram of tri- axis mobile platform of XYZ.
Specific embodiment
With reference to the accompanying drawing and the present invention is described further in specific embodiment.
Embodiment 1: as shown in figs 1 to 6, a kind of support device (branch for array microfluidic point sample microfluidic control device
Frame 6), which includes I-shaped connection grillage 601, the L-type fixed jaw 602 to stand upside down and the L-type activity stood upside down
Pawl 607, I-shaped 601 lower end side of connection grillage are fixedly connected with L-type fixed jaw 602, and bottom is provided with T-type sliding slot 603, T-type
T-type sliding block 604 is installed, T-type sliding block 604 is fixedly connected with L-type movable claw 607, and L-type fixed jaw 602 and L-type are living in sliding slot 603
Pawl 607 is connected by 605 spiral of screw rod, and the screw thread at 607 connection wire rod 605 of L-type fixed jaw 602 and L-type movable claw is reversed,
L-type fixed jaw 602 and 607 lower end inside of L-type movable claw are embedded into the groove 606 of 4 two sides of microfluidic control device, screw rod 605
One end is connected with handle 608.
Embodiment 2: as shown in figs 1 to 6, a kind of high throughput droplet array microfluid spot sample device, the T word including handstand
Type frame 1, tri- axis mobile platform 2 of XYZ, point template 3 and microfluidic control device 4 are equipped with tri- axis of XYZ on the vertical plate of T font frame 1
Mobile platform 2 is equipped with point template 3 on tri- axis mobile platform 2 of XYZ, and T font frame 1 is fixedly connected with horizontal cantilever beam 5, micro-
Flow control device 4 is fixedly connected on cantilever beam 5 by bracket 6 and is located at 3 upside of point template, and microfluidic control device 4 is connected with liquid
Body sample feeding device 7.
Preferably, above-mentioned microfluidic control device 4 includes fixed plate 401 and spotting template 402, and fixed plate 401 is removably
It is fixedly connected on 402 upper side of spotting template, upper end is provided with sample introduction micro-pipe 403, array point sample is provided in spotting template 402
Hole 404,404 upper end of array loading wells are provided with the groove 405 being connected to the upper end, and groove 405 is connected to sample introduction micro-pipe 403,
Screw thread guide rod is provided in fixed plate 401, screw thread guide rod uses nut check after passing through spotting template.
Preferably, above-mentioned sample introduction micro-pipe 403 is arranged more, the groove 405 of 404 upside of Duo Genjun subarray loading wells.
Preferably, above-mentioned groove 405 is communicated with waste liquid micro-pipe 406.
Preferably, above-mentioned tri- axis mobile platform 2 of XYZ includes that sequentially connected Z axis mobile station 8, X-axis mobile station 9 and Y-axis are moved
Dynamic platform 10, Z axis mobile station 8, X-axis mobile station 9 and Y-axis mobile station 10 include slide block guide rail pair, slide plate, are connected with platform driving
The slide plate of the screw-nut pair of motor, Z axis mobile station 8 is connected on vertical plate by slide block guide rail pair, and slide plate bottom is connected with
The vertical screw-nut pair for driving it to move, the slide plate of X-axis mobile station 9 are connected to Z axis mobile station 8 by slide block guide rail pair
On the level board of slide plate connection, slide plate bottom is connected with the vertical screw-nut pair of its movement of driving, the cunning of Y-axis mobile station 10
Plate is connected on the slide plate of X-axis mobile station 9 by slide block guide rail pair, and slide plate bottom is connected with the vertical lead screw of its movement of driving
Screw pair.
Preferably, heating plate 11 is provided between above-mentioned tri- axis mobile platform 2 of XYZ and point template 3.
Preferably, it is provided with heat-conducting plate 12 between above-mentioned heating plate 11 and point template 3, is arranged between heat-conducting plate 12 and heating plate 11
There is temperature sensor 13.
Preferably, above-mentioned bracket 6 includes that I-shaped connection grillage 601, the L-type fixed jaw 602 to stand upside down and the L-type stood upside down are living
Pawl 607, I-shaped 601 lower end side of connection grillage are fixedly connected with L-type fixed jaw 602, and bottom is provided with T-type sliding slot 603, T
T-type sliding block 604 is installed, T-type sliding block 604 is fixedly connected with L-type movable claw 607, L-type fixed jaw 602 and L-type in type sliding slot 603
Movable claw 607 is connected by 605 spiral of screw rod, and the screw thread at 607 connection wire rod 605 of L-type fixed jaw 602 and L-type movable claw is anti-
To L-type fixed jaw 602 and 607 lower end inside of L-type movable claw are embedded into the groove 606 of 4 two sides of microfluidic control device, screw rod
605 one end are connected with handle 608.
Preferably, aforesaid liquid sample feeding device 7 includes flow equalizing valve 701, microcavity syringe 702 and sample injector
703, the liquid outlet of microcavity syringe 702 is connected to the inlet of flow equalizing valve 701 by pipeline, and the inlet of upside is connected with sample
Product syringe 703, flow equalizing valve 701 and microcavity syringe 702 are fixedly connected on the top of cantilever beam 5, be provided in flow equalizing valve 701 with
The fluid chamber of inlet connection, fluid chamber are provided with multiple liquid outlets, and multiple liquid outlets connect more sample introduction micro-pipes 403.
Preferably, above-mentioned microcavity syringe 702 includes microcavity 704, piston 705 and piston rod 706, and the sealing of piston 705 is set
In in microcavity 704, side is connected with piston rod 706, and piston rod 706 is pierced by microcavity 704 with being tightly connected and is connected to sample introduction drive
The output shaft of dynamic motor 707, sample introduction driving motor 707 are connected on microcavity 704 by linear bearing 708.
The advantages of above-mentioned high throughput droplet array microfluid spot sample device, is as follows:
(1) device can fast implement by microfluidic control device and three axis mobile platforms and carry out small liquid on point template
The point sample of body, point sample is quickly accurate, is adapted to different convenient for point sample at different flow profiles using different microfluidic control devices
Demand, convenient for control control flow and speed, it is time saving and energy saving to operate, which also has that structure is simple, at low cost, operation side
Just quick feature；
(2) detachable structure for the microfluidic control device that the device uses, is conveniently replaceable the point template of different templates, using groove
Multiple array loading wells are connected to, the point sample of sample can be fast implemented, greatly improve point sample efficiency；
(3) more sample introduction micro-pipes are set, filling liquid can be carried out to multiple grooves being connected to array loading wells simultaneously, improve filling liquid
Efficiency reduces the flowing time of liquid in the trench, improves point sample efficiency；
(4) on the one hand waste liquid micro-pipe plays the role of Recycling of waste liquid, on the other hand plays scavenging action, improves the stream of spotting fluid
Dynamic property；
(5) mobile by the three-dimensional of the Z axis mobile station of connection, X-axis mobile station and Y-axis mobile station, point template can be fast implemented
The adjustment of position between microfluidic control device, adjustment is quickly accurate, improves point sample efficiency；
(6) heating plate is set, is easy to implement point template constant temperature point sample, avoids the influence because of temperature change to point sample；
(7) heat-conducting plate is set, can be realized soaking transmitting, avoid because local temperature it is excessively high caused by it is uneven, setting temperature passes
Sensor is capable of the temperature of real-time monitoring heating plate, convenient for controlling the heating temperature of point template；
(8) supporting structure being arranged, downside setting clamping microfluidic control device, is conveniently replaceable the Wake control dress of different templates
It sets, realizes different liquid form point samples, using screw rod, fixed jaw and movable claw structure, be convenient for rapid-assembling/disassembling, clamping stabilization can
It leans on, is also convenient for adapting to different size of microfluidic control device, greatly improve the utilization rate of equipment, reduce equipment cost；
(9) using flow equalizing valve, the liquid sample introduction device of microcavity syringe and sample injector, it can be realized spotting fluid sample
Product being rapidly injected and quickly adding；
(10) mobile using sample introduction driving motor driving piston rod, move back and forth on linear bearing, realizes the fast of spotting fluid
Speed is added.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
Those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, and should all contain
Within protection scope of the present invention, therefore, protection scope of the present invention should be based on the protection scope of the described claims lid.
Claims (1)
1. a kind of support device for array microfluidic point sample microfluidic control device, it is characterised in that: including I-shaped connection
Grillage (601), the L-type fixed jaw (602) to stand upside down and the L-type movable claw (607) to stand upside down, I-shaped connection grillage (601) lower end
Side is fixedly connected L-type fixed jaw (602), and bottom is provided with T-type sliding slot (603), is equipped with T-type sliding block in T-type sliding slot (603)
(604), T-type sliding block (604) is fixedly connected L-type movable claw (607), and L-type fixed jaw (602) and L-type movable claw (607) pass through silk
Bar (605) spiral connects, and the screw thread at L-type fixed jaw (602) and L-type movable claw (607) connection wire rod (605) is reversed, L-type
Fixed jaw (602) and L-type movable claw (607) lower end inside are embedded into the groove (606) of microfluidic control device (4) two sides.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811536258.8A CN109439514A (en) | 2018-12-14 | 2018-12-14 | A kind of support device for array microfluidic point sample microfluidic control device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811536258.8A CN109439514A (en) | 2018-12-14 | 2018-12-14 | A kind of support device for array microfluidic point sample microfluidic control device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109439514A true CN109439514A (en) | 2019-03-08 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811536258.8A Pending CN109439514A (en) | 2018-12-14 | 2018-12-14 | A kind of support device for array microfluidic point sample microfluidic control device |
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| CN (1) | CN109439514A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113996356A (en) * | 2021-10-27 | 2022-02-01 | 北京京东方技术开发有限公司 | Micro-fluidic chip, manufacturing method thereof and medical detection equipment |
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| CN113996356A (en) * | 2021-10-27 | 2022-02-01 | 北京京东方技术开发有限公司 | Micro-fluidic chip, manufacturing method thereof and medical detection equipment |
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