CN111727186A - 双杂环取代的吡啶-2(1h)-酮衍生物、其制法与医药上的用途 - Google Patents

双杂环取代的吡啶-2(1h)-酮衍生物、其制法与医药上的用途 Download PDF

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Publication number
CN111727186A
CN111727186A CN201980009653.7A CN201980009653A CN111727186A CN 111727186 A CN111727186 A CN 111727186A CN 201980009653 A CN201980009653 A CN 201980009653A CN 111727186 A CN111727186 A CN 111727186A
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alkyl
compound
alkoxy
ring
coc
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CN111727186B (zh
Inventor
胡斌
朱经峰
方志华
杨斐
林崇懒
华默嘉
刘洋
关慧平
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Yangtze River Pharmaceutical Group Co Ltd
Shanghai Haiyan Pharmaceutical Technology Co Ltd
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Yangtze River Pharmaceutical Group Co Ltd
Shanghai Haiyan Pharmaceutical Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

提供双杂环取代的吡啶‑2(1H)‑酮衍生物、其制法与医药上的用途。具体地，提供式(Ⅱ)化合物或其药学上可接受的盐、立体异构体或溶剂化物，及其制备方法和应用。

Description

PCT国内申请，说明书已公开。

Claims (35)

  1. PCT国内申请，权利要求书已公开。
CN201980009653.7A 2018-11-11 2019-11-11 双杂环取代的吡啶-2(1h)-酮衍生物、其制法与医药上的用途 Active CN111727186B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201811335754 2018-11-11
CN2018113357547 2018-11-11
PCT/CN2019/117221 WO2020094156A1 (zh) 2018-11-11 2019-11-11 双杂环取代的吡啶-2(1h)-酮衍生物、其制法与医药上的用途

Publications (2)

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CN111727186A true CN111727186A (zh) 2020-09-29
CN111727186B CN111727186B (zh) 2022-11-08

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CN (1) CN111727186B (zh)
WO (1) WO2020094156A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022057858A1 (zh) * 2020-09-17 2022-03-24 浙江海正药业股份有限公司 酰胺膦氧类衍生物及其制备方法和用途
CA3237199A1 (en) 2021-11-02 2023-05-11 Flare Therapeutics Inc. Pparg inverse agonists and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103987697A (zh) * 2011-10-14 2014-08-13 百时美施贵宝公司 作为因子xia抑制剂的取代的四氢异喹啉化合物
WO2014160592A2 (en) * 2013-03-27 2014-10-02 Merck Sharp & Dohme Corp. FACTOR XIa INHIBITORS
CN104136431A (zh) * 2011-12-21 2014-11-05 小野药品工业株式会社 作为凝血因子XIa抑制剂的吡啶酮和嘧啶酮衍生物
CN106496249A (zh) * 2015-09-07 2017-03-15 江苏恒瑞医药股份有限公司 噁唑并吲哚类衍生物、其制备方法及其在医药上的应用

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103987697A (zh) * 2011-10-14 2014-08-13 百时美施贵宝公司 作为因子xia抑制剂的取代的四氢异喹啉化合物
CN104136431A (zh) * 2011-12-21 2014-11-05 小野药品工业株式会社 作为凝血因子XIa抑制剂的吡啶酮和嘧啶酮衍生物
WO2014160592A2 (en) * 2013-03-27 2014-10-02 Merck Sharp & Dohme Corp. FACTOR XIa INHIBITORS
CN106496249A (zh) * 2015-09-07 2017-03-15 江苏恒瑞医药股份有限公司 噁唑并吲哚类衍生物、其制备方法及其在医药上的应用

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CN111727186B (zh) 2022-11-08

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