CN111712516A - 粘附受体构建体及其在自然杀伤细胞免疫疗法中的用途 - Google Patents
粘附受体构建体及其在自然杀伤细胞免疫疗法中的用途 Download PDFInfo
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- CN111712516A CN111712516A CN201980011826.9A CN201980011826A CN111712516A CN 111712516 A CN111712516 A CN 111712516A CN 201980011826 A CN201980011826 A CN 201980011826A CN 111712516 A CN111712516 A CN 111712516A
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- C12N5/0646—Natural killers cells [NK], NKT cells
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- A—HUMAN NECESSITIES
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- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/59—Reproductive system, e.g. uterus, ovaries, cervix or testes
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- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
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- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13041—Use of virus, viral particle or viral elements as a vector
- C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862628797P | 2018-02-09 | 2018-02-09 | |
| US62/628,797 | 2018-02-09 | ||
| US201862736965P | 2018-09-26 | 2018-09-26 | |
| US62/736,965 | 2018-09-26 | ||
| PCT/IB2019/000141 WO2019155286A2 (en) | 2018-02-09 | 2019-02-07 | Adhesion receptor constructs and uses thereof in natural killer cell immunotherapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111712516A true CN111712516A (zh) | 2020-09-25 |
Family
ID=67548047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980011826.9A Pending CN111712516A (zh) | 2018-02-09 | 2019-02-07 | 粘附受体构建体及其在自然杀伤细胞免疫疗法中的用途 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20210054409A1 (https=) |
| EP (1) | EP3749686A4 (https=) |
| JP (1) | JP2021512614A (https=) |
| CN (1) | CN111712516A (https=) |
| AU (1) | AU2019219452A1 (https=) |
| CA (1) | CA3089167A1 (https=) |
| SG (1) | SG11202007183PA (https=) |
| WO (1) | WO2019155286A2 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115197326A (zh) * | 2022-06-27 | 2022-10-18 | 安徽医科大学第一附属医院 | 融合蛋白及其编码基因和重组载体以及它们的应用 |
| CN116554300A (zh) * | 2023-04-27 | 2023-08-08 | 湖北医药学院 | 一种能与艰难拟梭菌毒素TcdB相互作用的多肽及其应用 |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015259877B2 (en) | 2014-05-15 | 2021-02-25 | National University Of Singapore | Modified natural killer cells and uses thereof |
| US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
| KR102660336B1 (ko) | 2017-03-27 | 2024-04-26 | 내셔널 유니버시티 오브 싱가포르 | 절단된 nkg2d 키메라 수용체 및 자연 살해 세포 면역요법에서의 그의 용도 |
| MX2019011570A (es) | 2017-03-27 | 2019-11-18 | Nat Univ Singapore | Lineas celulares estimuladoras para expansion y activacion ex vivo de celulas asesinas naturales. |
| AU2019219454A1 (en) | 2018-02-09 | 2020-08-27 | National University Of Singapore | Activating chimeric receptors and uses thereof in natural killer cell immunotherapy |
| CN112055717B (zh) | 2018-04-02 | 2024-04-26 | 新加坡国立大学 | 用在免疫细胞中表达的膜结合抗细胞因子非信号传导粘合剂中和人细胞因子 |
| EP3844186A4 (en) | 2018-08-29 | 2022-08-17 | National University of Singapore | METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS |
| US12590148B2 (en) | 2018-11-26 | 2026-03-31 | Nkarta, Inc. | Methods for the simultaneous expansion of multiple immune cell types, related compositions and uses of same in cancer immunotherapy |
| AU2020232691B2 (en) | 2019-03-05 | 2023-06-29 | Nkarta, Inc. | CD19-directed chimeric antigen receptors and uses thereof in immunotherapy |
| CN110396131B (zh) * | 2019-08-23 | 2020-07-10 | 北京鼎成肽源生物技术有限公司 | 一种ErbB2单链抗体、靶向人ErbB2的嵌合抗原受体、重组载体、重组细胞和应用 |
| CA3150224A1 (en) | 2019-09-10 | 2021-03-18 | Obsidian Therapeutics, Inc. | Ca2 compositions and methods for tunable regulation |
| CN120098148B (zh) * | 2025-05-09 | 2025-07-22 | 四川康德赛医疗科技有限公司 | 一种工程化巨噬细胞制备及抗纤维化的应用 |
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| WO2014117121A1 (en) * | 2013-01-28 | 2014-07-31 | St. Jude Children's Research Hospital, Inc. | A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease |
| WO2017027325A1 (en) * | 2015-08-07 | 2017-02-16 | Imaginab, Inc. | Antigen binding constructs to target molecules |
| WO2017079694A2 (en) * | 2015-11-04 | 2017-05-11 | Priceman Saul J | Chimeric antigen receptors targeting her2 |
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| US5595756A (en) * | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
| CA2782333C (en) * | 2009-12-02 | 2019-06-04 | Imaginab, Inc. | J591 minibodies and cys-diabodies for targeting human prostate specific membrane antigen (psma) and methods for their use |
| AU2015259877B2 (en) * | 2014-05-15 | 2021-02-25 | National University Of Singapore | Modified natural killer cells and uses thereof |
| EP3157958B1 (en) * | 2014-06-18 | 2020-05-06 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Car-expressing nk-92 cells as cell therapeutic agents |
| SG11201810640RA (en) * | 2016-06-08 | 2018-12-28 | Intrexon Corp | Cd33 specific chimeric antigen receptors |
| KR102660336B1 (ko) * | 2017-03-27 | 2024-04-26 | 내셔널 유니버시티 오브 싱가포르 | 절단된 nkg2d 키메라 수용체 및 자연 살해 세포 면역요법에서의 그의 용도 |
-
2019
- 2019-02-07 EP EP19750822.9A patent/EP3749686A4/en not_active Withdrawn
- 2019-02-07 US US16/967,888 patent/US20210054409A1/en not_active Abandoned
- 2019-02-07 CN CN201980011826.9A patent/CN111712516A/zh active Pending
- 2019-02-07 AU AU2019219452A patent/AU2019219452A1/en not_active Abandoned
- 2019-02-07 WO PCT/IB2019/000141 patent/WO2019155286A2/en not_active Ceased
- 2019-02-07 CA CA3089167A patent/CA3089167A1/en not_active Abandoned
- 2019-02-07 SG SG11202007183PA patent/SG11202007183PA/en unknown
- 2019-02-07 JP JP2020542380A patent/JP2021512614A/ja active Pending
Patent Citations (3)
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| WO2014117121A1 (en) * | 2013-01-28 | 2014-07-31 | St. Jude Children's Research Hospital, Inc. | A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease |
| WO2017027325A1 (en) * | 2015-08-07 | 2017-02-16 | Imaginab, Inc. | Antigen binding constructs to target molecules |
| WO2017079694A2 (en) * | 2015-11-04 | 2017-05-11 | Priceman Saul J | Chimeric antigen receptors targeting her2 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115197326A (zh) * | 2022-06-27 | 2022-10-18 | 安徽医科大学第一附属医院 | 融合蛋白及其编码基因和重组载体以及它们的应用 |
| CN116554300A (zh) * | 2023-04-27 | 2023-08-08 | 湖北医药学院 | 一种能与艰难拟梭菌毒素TcdB相互作用的多肽及其应用 |
| CN116554300B (zh) * | 2023-04-27 | 2023-10-24 | 湖北医药学院 | 一种能与艰难拟梭菌毒素TcdB相互作用的多肽及其应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA3089167A1 (en) | 2019-08-15 |
| EP3749686A2 (en) | 2020-12-16 |
| AU2019219452A1 (en) | 2020-08-27 |
| WO2019155286A3 (en) | 2019-09-26 |
| SG11202007183PA (en) | 2020-08-28 |
| EP3749686A4 (en) | 2022-01-05 |
| WO2019155286A2 (en) | 2019-08-15 |
| JP2021512614A (ja) | 2021-05-20 |
| US20210054409A1 (en) | 2021-02-25 |
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