CN111700863A - Diflubenzuron premix for animals and preparation method thereof - Google Patents
Diflubenzuron premix for animals and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a fly-killing premix for animals and a preparation method thereof, and the fly-killing premix for animals comprises the following components in percentage by total weight: 5-10 wt% of diflubenzuron, 10-30 wt% of a diluent, 2-7 wt% of a flavoring agent, 40-70 wt% of a carrier, 5-10 wt% of an adhesive, 1-5 wt% of a wetting agent and 2-8 wt% of a lubricant. The premixing agent adopts the micronization technology in the preparation process, the particle size of the diflubenzuron becomes smaller, and the dissolubility of the diflubenzuron is greatly increased, so that the diflubenzuron premixing agent can be mixed into feed for administration and can also be mixed into drinking water for administration. The premix prepared by the invention has the advantages of stable curative effect, good drug effect, high uniformity and good stability.
Description
Technical Field
The invention belongs to the technical field of pesticides, and particularly relates to a diflubenzuron premix for animals and a preparation method thereof.
Background
People have higher and higher requirements on livestock and poultry breeding environment, but flies and fly maggots are always a big problem troubling farms. Flies are one of four pests, which not only pollute the environment, but also are carriers of viruses and bacteria, and many diseases of human beings are directly related to flies such as flies. In a farm, the control of flies is a difficult and complicated work, and the control of drugs is an important means, but most fly killers have high toxicity, and residual drugs after use cause serious environmental pollution, even change the ecosystem. Moreover, most fly-killing agents are harmful to human bodies, and seriously threaten the health of the human bodies.
At present, the drugs for controlling fly maggots in livestock and poultry manure mainly comprise traditional insecticides such as organophosphorus insecticides, amitraz and pyrethroid insecticides, and insect growth regulator cyromazine. However, the traditional pesticide is used for controlling fly maggots in the livestock and poultry manure, and has some disadvantages: for example, organophosphorus insecticides and amitraz have high toxicity and high drug residue, and the livestock and poultry manure has poisoning risk when being reused; the pyrethroid drugs have relatively low toxicity, but poor residual effect and quick generation of fly maggot drug resistance. The only special fly maggot resisting medicine for veterinary medicine is the insect growth regulator cyromazine, although the effect of killing the cyromazine is good, the only special fly maggot resisting medicine is used for decades, with the longer and longer use time of the cyromazine, the cyromazine is likely to appear, and the more and more addition of the cyromazine in the feed is inevitably caused. The residual amount of melamine, a metabolite of cyromazine, also increases. At present, addition of cyromazine into feed is forbidden in Japan, Europe and the like, and a medicine which can be used with cyromazine alternately and is safe to people and livestock, low in toxicity and environment-friendly and resistant to fly maggots is urgently needed to be found.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a novel veterinary diflubenzuron premix and a preparation method thereof.
In order to achieve the above objects, a first aspect of the present invention provides a diflubenzuron premix for animals, which comprises, based on the total weight of the diflubenzuron premix for animals: 5-10 wt% of diflubenzuron, 10-30 wt% of a diluent, 2-7 wt% of a flavoring agent, 40-70 wt% of a carrier, 5-10 wt% of an adhesive, 1-5 wt% of a wetting agent and 2-8 wt% of a lubricant.
In the present invention, diflubenzuron is a specific low-toxicity insecticide, belonging to the benzoyloxyphenylurea insecticides. High safety, rat oral LD50> 5000 mg/kg. The insecticidal mechanism is completely different from that of the conventional insecticide, and the insecticidal composition is neither nerve agent nor cholinesterase inhibitor, and has the main effects of inhibiting chitin synthesis of insect epidermis and damaging and destroying endocrine and glandular organs such as fat body, pharyngeal side body and the like, thereby preventing the insects from successfully molting and metamorphosis. The main modes of action are stomach toxicity and contact poisoning. Accumulated poisoning is caused after the pests eat the bait, because of the lack of chitin, the larvae can not form new epidermis, the molting is difficult, and the pupation is blocked; the imagoes are difficult to eclose and lay eggs; eggs can not normally develop, and the hatched larval epidermis is dead due to lack of hardness, so that the whole generation of pests is affected, which is the advantage of diflubenzuron.
The premixing agent is a preparation formulation which is convenient for clinical application and is easy to use by feeding workers, is particularly suitable for preventive treatment of the whole group of animals, and if the insecticide is prepared into the premixing agent and is directly added into the feed for feeding, the premixing agent not only saves time and labor, but also can avoid stress to the animals when in use.
In the veterinary drug premix, the safety and the drug effect of the drug are closely related to the uniformity, the uniformity of the premix product is an important factor for ensuring the product quality, the uniformity of the product is closely related to the selection of auxiliary materials and the preparation process, the auxiliary materials are additives in the drug preparation except for main drugs, the auxiliary materials have important functions of solubilization, solubilization assistance, sustained and controlled release and the like besides the functions of endowment, serving as carriers and improving the stability, and have great relation to the improvement of the curative effect of the drug and the reduction of adverse reactions, and the selection of the proper auxiliary materials is not only related to the uniformity, the fluidity and the stability of the premix, but also related to the safety and the curative effect of the drug.
According to the present invention, preferably, the diluent is microcrystalline cellulose and/or lactose.
Diluents are generally used to fill weight and volume and may also act as a binder; the invention adopts specific diluent to ensure that the fluidity of the premixed material is moderate, and the premixed material cannot be adsorbed on the carrier if the premixed material is too smooth, and cannot be dispersed uniformly if the premixed material is too rough.
According to the invention, preferably, the flavoring agent is an organic acid, preferably citric acid, and/or aspartame.
The flavoring agent is a pharmaceutical adjuvant for improving or shielding the peculiar smell of the medicament on one hand, and the organic acid flavoring agent is adopted to increase the solubility of the diflubenzuron to a certain degree on the other hand.
According to the invention, the carrier is preferably corn flour and calcium carbonate, and the weight ratio of the corn flour to the calcium carbonate is 1: 1-3.
By carrier is meant a feedable material capable of receiving and carrying an active ingredient, and the carrier of the present invention serves to dilute and improve flowability so that the active ingredient is more readily distributed into the feed.
According to the present invention, preferably, the binder is sodium carboxymethyl cellulose and/or polyvinyl alcohol.
The adhesive is solid powder or viscous liquid which can make non-viscous or low-viscosity material aggregate and bond into granules or compression-formed into form with viscosity. Since diflubenzuron is poorly soluble, it cannot be used after dissolving in water, and thus, the administration mode is limited. The invention adds the adhesive and other auxiliary materials to lead the diflubenzuron premix to be mixed into feed for administration and also mixed into drinking water for administration.
According to the present invention, preferably, the wetting agent is polysorbate 80 and/or absolute ethanol.
According to the invention, preferably, the lubricant is magnesium stearate.
The second aspect of the present invention provides a preparation method of the above diflubenzuron premix for livestock, which comprises:
(1) grinding diflubenzuron, diluent, correctant, carrier, binder and lubricant respectively, and sieving;
(2) pulverizing and mixing the ground and sieved diflubenzuron and a diluent to obtain first mixed powder;
(3) crushing and mixing the first mixed powder and the ground and sieved flavoring agent to obtain second mixed powder;
(4) crushing and mixing the second mixed powder and the ground and sieved carrier to obtain third mixed powder;
(5) and uniformly mixing the third mixed powder and the EM bacterial powder according to an equivalent incremental method, and then uniformly mixing the mixture with a wetting agent, the ground and sieved lubricant and an adhesive to obtain the premix.
In the mixing process of the effective components and the auxiliary materials of the veterinary drug premix, on one hand, the mixing machine plays a mixing role on the materials, and on the other hand, because the particles of the mixed materials have the difference of relative density, granularity and surface characteristics, automatic grading is certainly generated during movement, and the uniform state of the materials is damaged by the automatic grading, so the mixing mode and the mixing sequence of the materials are further limited, and the uniformity, the stability and the safety of the mixed materials are greatly improved.
According to the invention, in step (1), the grinding time is 5-10min, and the particle size after grinding and sieving is not more than 80 meshes;
in the step (2), the crushing and mixing are carried out in a jet mill, the feeding speed of the jet mill is 3.0-5.0kg/h, and the air pressure is 2.5 × 105-4.5×105Pa; the particle size of the first mixed powder is D90 not more than 30 mu m;
in the step (3), the crushing and mixing are carried out in a ball mill, and the crushing and mixing time is 10-15 min;
in the step (4), the crushing and mixing are carried out in a ball mill, and the crushing and mixing time is 15-25 min;
in the step (5), mixing is performed in a granulator.
In the production process of the premix, the preparation process directly influences the uniformity of products, not only accurate batching is required, but also the uniform distribution of effective components in the whole batch of the premix must be ensured, and equipment, material physical properties, feeding sequence and mixing time in the preparation process are all important factors.
In a third aspect of the invention, the application of the diflubenzuron premix for animals in animal feed is provided.
The technical scheme of the invention has the following beneficial effects:
(1) cyromazine can be metabolized into melamine in animals and in the environment, and long-term enrichment causes more harm to human beings and the environment. The diflubenzuron (diflubenzuron) belongs to an insect growth regulator, has an action mechanism of interfering the synthesis of chitin in the life cycle of flies, has low toxicity to human and swine, is developed into a high-efficiency low-toxicity fly maggot killing agent, and has wide application prospect in animal and plant breeding industry.
(2) The premix of the invention is added with the adhesive and the organic acid, and the dissolubility of the diflubenzuron is increased.
(3) In the pretreatment process of the preparation method, the conditions are mild, the physical change is realized, the chemical reaction does not exist, the yield of the diflubenzuron can be kept at 100 percent, and no loss is caused.
(4) The preparation process of the premix adopts a micronization technology, so that the particle size of the diflubenzuron is reduced, and the solubility of the diflubenzuron is increased, so that the diflubenzuron premix can be mixed into feed for administration and can also be mixed into drinking water for administration.
(5) The invention has the advantages of simple and feasible production and preparation process, controllable quality, simple operation, low cost and little pollution.
(6) The premix prepared by the invention has stable curative effect, good drug effect, high uniformity and good stability.
Additional features and advantages of the invention will be set forth in the detailed description which follows.
Detailed Description
Preferred embodiments of the present invention will be described in more detail below. While the following describes preferred embodiments of the present invention, it should be understood that the present invention may be embodied in various forms and should not be limited by the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art.
Example 1
The embodiment provides a diflubenzuron premix for animals, which consists of the following components: 67g of diflubenzuron, 200g of microcrystalline cellulose, 50g of citric acid, 300g of corn flour, 233g of calcium carbonate, 75g of sodium carboxymethylcellulose, 25g of polysorbate 80 and 50g of magnesium stearate;
the preparation method comprises the following steps: (1) grinding diflubenzuron, microcrystalline cellulose, citric acid, corn flour, calcium carbonate, sodium carboxymethylcellulose and magnesium stearate in a prescribed amount for 10min respectively, and sieving with a 80-mesh sieve for later use;
(2) the milled and sieved diflubenzuron and microcrystalline cellulose are fed into a jet mill by dry nitrogen (the feed speed of the jet mill is 5.0kg/h, and the air pressure is 4.5 × 105Pa), obtaining first mixed powder with the particle size D90 being less than or equal to 30 mu m;
(3) adding the ground and sieved citric acid into the first mixed powder, and crushing and mixing the mixture in a ball mill for 15min to obtain second mixed powder;
(4) adding the ground and sieved corn flour and calcium carbonate into the second mixed powder, and crushing and mixing the corn flour and the calcium carbonate in a ball mill for 25min to obtain third mixed powder;
5) and putting the third mixed powder into a granulator, adding the ground and sieved magnesium stearate and sodium carboxymethylcellulose, spraying polysorbate 80, and uniformly mixing to obtain the veterinary diflubenzuron premix.
Example 2
The embodiment provides a diflubenzuron premix for animals, which consists of the following components: 67g of diflubenzuron, 200g of microcrystalline cellulose, 50g of citric acid, 300g of corn flour, 233g of calcium carbonate, 75g of sodium carboxymethylcellulose, 25g of absolute ethyl alcohol and 50g of magnesium stearate;
the preparation method comprises the following steps: (1) grinding diflubenzuron, microcrystalline cellulose, citric acid, corn flour, calcium carbonate, sodium carboxymethylcellulose and magnesium stearate in a prescribed amount for 10min respectively, and sieving with a 80-mesh sieve for later use;
(2) the milled and sieved diflubenzuron and microcrystalline cellulose are fed into a jet mill by dry nitrogen (the feed speed of the jet mill is 5.0kg/h, and the air pressure is 4.5 × 105Pa), obtaining first mixed powder with the particle size D90 being less than or equal to 30 mu m;
(3) adding the ground and sieved citric acid into the first mixed powder, and crushing and mixing the mixture in a ball mill for 15min to obtain second mixed powder;
(4) adding the ground and sieved corn flour and calcium carbonate into the second mixed powder, and crushing and mixing the corn flour and the calcium carbonate in a ball mill for 25min to obtain third mixed powder;
5) and putting the third mixed powder into a granulator, adding the ground and sieved magnesium stearate and sodium carboxymethylcellulose, spraying absolute ethyl alcohol, and uniformly mixing to obtain the diflubenzuron premix for the livestock.
Example 3
The embodiment provides a diflubenzuron premix for animals, which consists of the following components: 67g of diflubenzuron, 200g of microcrystalline cellulose, 50g of aspartame, 300g of corn flour, 233g of calcium carbonate, 75g of sodium carboxymethylcellulose, 25g of polysorbate 80 and 50g of magnesium stearate;
the preparation method comprises the following steps: (1) grinding diflubenzuron, microcrystalline cellulose, aspartame, corn flour, calcium carbonate, sodium carboxymethylcellulose and magnesium stearate in the formula amount for 10min respectively, and sieving with a 80-mesh sieve for later use;
(2) the milled and sieved diflubenzuron and microcrystalline cellulose are fed into a jet mill by dry nitrogen (the feed speed of the jet mill is 5.0kg/h, and the air pressure is 4.5 × 105Pa), obtaining first mixed powder with the particle size D90 being less than or equal to 30 mu m;
(3) adding the ground and sieved aspartame into the first mixed powder, and crushing and mixing the mixture in a ball mill for 15min to obtain second mixed powder;
(4) adding the ground and sieved corn flour and calcium carbonate into the second mixed powder, and crushing and mixing the corn flour and the calcium carbonate in a ball mill for 25min to obtain third mixed powder;
5) and putting the third mixed powder into a granulator, adding the ground and sieved magnesium stearate and sodium carboxymethylcellulose, spraying polysorbate 80, and uniformly mixing to obtain the veterinary diflubenzuron premix.
Example 4
The embodiment provides a diflubenzuron premix for animals, which consists of the following components: 67g of diflubenzuron, 200g of lactose, 50g of citric acid, 300g of corn flour, 233g of calcium carbonate, 75g of sodium carboxymethylcellulose, 25g of polysorbate 80 and 50g of magnesium stearate;
the preparation method comprises the following steps: (1) grinding diflubenzuron, lactose, citric acid, corn flour, calcium carbonate, sodium carboxymethylcellulose and magnesium stearate in a prescribed amount for 10min respectively, and sieving with a 80-mesh sieve for later use;
(2) feeding the milled and sieved diflubenzuron and lactose into jet mill with dry nitrogen (feeding speed of jet mill is 5.0kg/h, air pressure is 4.5 × 10)5Pa), obtaining first mixed powder with the particle size D90 being less than or equal to 30 mu m;
(3) adding the ground and sieved citric acid into the first mixed powder, and crushing and mixing the mixture in a ball mill for 15min to obtain second mixed powder;
(4) adding the ground and sieved corn flour and calcium carbonate into the second mixed powder, and crushing and mixing the corn flour and the calcium carbonate in a ball mill for 25min to obtain third mixed powder;
5) and putting the third mixed powder into a granulator, adding the ground and sieved magnesium stearate and sodium carboxymethylcellulose, spraying polysorbate 80, and uniformly mixing to obtain the veterinary diflubenzuron premix.
Example 5
The embodiment provides a diflubenzuron premix for animals, which consists of the following components: 67g of diflubenzuron, 200g of microcrystalline cellulose, 50g of citric acid, 300g of corn flour, 233g of calcium carbonate, 75g of polyvinyl alcohol, 25g of polysorbate 80 and 50g of magnesium stearate;
the preparation method comprises the following steps: (1) grinding diflubenzuron, microcrystalline cellulose, citric acid, corn flour, calcium carbonate, polyvinyl alcohol and magnesium stearate in the formula amount for 10min respectively, and sieving with a 80-mesh sieve for later use;
(2) the milled and sieved diflubenzuron and microcrystalline cellulose are fed into a jet mill by dry nitrogen (the feed speed of the jet mill is 5.0kg/h, and the air pressure is 4.5 × 105Pa), obtaining first mixed powder with the particle size D90 being less than or equal to 30 mu m;
(3) adding the ground and sieved citric acid into the first mixed powder, and crushing and mixing the mixture in a ball mill for 15min to obtain second mixed powder;
(4) adding the ground and sieved corn flour and calcium carbonate into the second mixed powder, and crushing and mixing the corn flour and the calcium carbonate in a ball mill for 25min to obtain third mixed powder;
5) and putting the third mixed powder into a granulator, adding the ground and sieved magnesium stearate and polyvinyl alcohol, spraying polysorbate 80, and uniformly mixing to obtain the veterinary diflubenzuron premix.
Example 6
The embodiment provides a diflubenzuron premix for animals, which consists of the following components: 67g of diflubenzuron, 200g of microcrystalline cellulose, 50g of citric acid, 300g of corn flour, 233g of calcium carbonate, 75g of polyvinyl alcohol, 25g of absolute ethyl alcohol and 50g of magnesium stearate;
the preparation method comprises the following steps: (1) grinding diflubenzuron, microcrystalline cellulose, citric acid, corn flour, calcium carbonate, polyvinyl alcohol and magnesium stearate in the formula amount for 7min respectively, and sieving with a 80-mesh sieve for later use;
(2) feeding the milled and sieved diflubenzuron and microcrystalline cellulose into jet mill with dry nitrogen (feeding speed of jet mill is 4.0kg/h, air pressure is 3.0 × 10)5Pa), obtaining first mixed powder with the particle size D90 being less than or equal to 30 mu m;
(3) adding the ground and sieved citric acid into the first mixed powder, and crushing and mixing the mixture in a ball mill for 7min to obtain second mixed powder;
(4) adding the ground and sieved corn flour and calcium carbonate into the second mixed powder, and crushing and mixing the corn flour and the calcium carbonate in a ball mill for 20min to obtain third mixed powder;
5) and putting the third mixed powder into a granulator, adding the ground and sieved magnesium stearate and polyvinyl alcohol, spraying absolute ethyl alcohol, and uniformly mixing to obtain the diflubenzuron premix for the livestock.
Comparative example 1
The formula of the premix of the comparative example is the same as that of example 1, except that the preparation method is different, and the preparation method of the comparative example is as follows: sieving diflubenzuron, microcrystalline cellulose, citric acid, corn flour, calcium carbonate, sodium carboxymethylcellulose and magnesium stearate with 80-mesh sieve respectively, and mixing the sieved components with polysorbate 80 to obtain the premix.
Comparative example 2
This comparative example is different from example 1 only in that 67g of diflubenzuron was replaced with 67g of cyromazine, and the other examples were the same as example 1.
Test example 1
The content uniformity, the drying weight loss, the water dispersibility and the like are detected according to the method recorded in Chinese animal pharmacopoeia. Wherein the content uniformity is not higher than 15, the drying weight loss is not more than 10 percent, and the sedimentation volume ratio is not lower than 0.90.
TABLE 1 premix performance test results for different prescriptions
As can be seen from Table 1, the content uniformity, appearance, loss on drying, and sedimentation volume ratio of the premixes prepared in examples 1-6 of the present invention all meet the requirements. Comparative example 1 the content uniformity, appearance and sedimentation volume ratio were all unsatisfactory because of poor mixing.
Test example 2
1. Test materials
Diflubenzuron premix (prepared from example 1)
2. Test methods and results
2.1 illumination test:
three samples of diflubenzuron premix (lot numbers 2019102001, 2019102002, and 2019102003, respectively) prepared according to the method of example 1 were filled with nitrogen gas, sealed in colorless transparent vials. The sample was placed under the condition of 4500. + -. 500Lux for 10 days, and sampled at fixed time intervals of 0, 5 and 10 days, and the properties, relative marker content and fluidity thereof were evaluated, and the results are shown in Table 2-1.
TABLE 2-1 Ten-day illumination test results
2.2 accelerated test
Three samples of the 6.7% diflubenzuron premix (lots 2019102001, 2019102002, and 2019102003, respectively) prepared according to the method of example 1 were placed at a temperature of 40 C.at 2 C.at a relative humidity of 75 C.at 5% for accelerated testing. Adopting a sodium nitrite saturated solution as a humidifying agent, placing the humidifying agent at the bottom of a dryer, placing three batches of samples in a stability test box, adjusting the temperature to 40-2 ℃, regularly observing for 6 months, sampling once in 0 th, 1 st, 2 th, 3 th and 6 th months respectively, and evaluating the properties, the relative identification content and the fluidity, wherein the results are shown in a table 2-2.
TABLE 2-2 accelerated test results (40 soil 2 ℃ C., RH 75 soil 5%)
The test results show that the three batches of diflubenzuron premix prepared in the example 1 have stable properties and no obvious change in content in the illumination test and the acceleration test, and the prepared premix has good fluidity.
Test example 3
1. Test materials: the premix prepared in example 1; the premix prepared in example 2; premix prepared in comparative example 2.
2. The test method comprises the following steps: selecting 80 commercial pigs in a certain pig farm, and dividing the commercial pigs into 4 groups, wherein each 20 commercial pigs form one group. Group a is the premix feeding group prepared in example 1, group B is the premix feeding group prepared in example 2, group C is the premix feeding group prepared in comparative example 2, and group D is the blank control group. Animal groups and treatments are given in table 3 below.
Table 3 test animal grouping and handling
The group a, the group B and the group C were fed with the premix prepared in example 1, the premix prepared in example 2 and the premix prepared in comparative example 2, respectively, starting on day 6 for 7 consecutive days.
Pig manure is collected on days 1, 3 and 5 (no medicine feeding), 6, 8, 10 and 12 (medicine using period, days 13, 15, 17 and 19 (after stopping medicine), the collection points are uniformly distributed, the manure at different sampling points of each group is mixed and stirred uniformly, and the total sampling amount of each group is 1L.
3. Evaluation method each sample was divided into 6 portions and placed in 6 beakers of 200ml,
the mouth of the cup was sealed with gauze, and cultured in an environment at a temperature of 25 ℃ and a humidity of about 60% for 3 weeks. During this period, the occurrence of live fly maggots and dead fly maggots was counted, and the average death rate of fly maggots in 6 beakers of each sample was calculated.
4. Results and discussion
The average mortality of fly maggots in the different treated pig feces is shown in Table 4. These data were analyzed.
TABLE 4 mortality of fly maggots in feces (%)
The results show that the maggots in pig manure of the groups A and B show 100% of death rate from the day after administration to 3 days after withdrawal and the maggots in pig manure of the groups C from the day after administration to 1 day after withdrawal, and the difference between the maggots and the pig manure is obvious compared with the blank control group.
Compared with the group A, the group B and the group C which are used together for 7 days, the group A, the group B and the group C have the same effect of clinically controlling the fly maggots, and the difference is not obvious. The drug effect of the A group and the B group is longer than that of the C group, so the effect of feeding the diflubenzuron premix is optimal. Moreover, the premixing agent is more convenient, more economical and more practical to use. More importantly, when cyromazine is fed to pigs, the risk of melamine residue as a metabolite exists, but the diflubenzuron premix provided by the invention can completely solve the problem of melamine residue in pork and other foods.
Claims (7)
1. The diflubenzuron premix for the animals is characterized by comprising the following components in percentage by weight based on the total weight of the diflubenzuron premix for the animals: 0.3-1 wt% of diflubenzuron, 10-30 wt% of diluent, 2-7 wt% of flavoring agent, 40-70 wt% of carrier, 5-10 wt% of adhesive, 1-5 wt% of wetting agent and 2-8 wt% of lubricant;
wherein the diluent is microcrystalline cellulose and/or lactose;
wherein, the flavoring agent is organic acid and/or aspartame, and the organic acid is preferably citric acid;
wherein the carrier is corn flour and calcium carbonate, and the weight ratio of the corn flour to the calcium carbonate is 1: 1-3.
2. The animal diflubenzuron premix of claim 1 wherein the binder is sodium carboxymethylcellulose and/or polyvinyl alcohol.
3. The animal diflubenzuron premix of claim 1, wherein the wetting agent is polysorbate 80 and/or absolute ethanol.
4. The veterinary diflubenzuron premix of claim 1 wherein the lubricant is magnesium stearate.
5. The process for preparing a diflubenzuron premix for veterinary use as claimed in any of claims 1 to 7, characterized in that it comprises:
(1) grinding diflubenzuron, diluent, correctant, carrier, binder and lubricant respectively, and sieving;
(2) pulverizing and mixing the ground and sieved diflubenzuron and a diluent to obtain first mixed powder;
(3) crushing and mixing the first mixed powder and the ground and sieved flavoring agent to obtain second mixed powder;
(4) crushing and mixing the second mixed powder and the ground and sieved carrier to obtain third mixed powder;
(5) and uniformly mixing the third mixed powder with a wetting agent, the ground and sieved lubricant and an adhesive to obtain the premix.
6. The preparation method according to claim 1, wherein in the step (1), the grinding time is 5-10min, and the particle size after grinding and sieving is not more than 80 meshes;
in the step (2), the crushing and mixing are carried out in a jet mill, the feeding speed of the jet mill is 3.0-5.0kg/h, and the air pressure is 2.5 × 105-4.5×105Pa; the particle size of the first mixed powder is D90 not more than 30 mu m;
in the step (3), the crushing and mixing are carried out in a ball mill, and the crushing and mixing time is 10-15 min;
in the step (4), the crushing and mixing are carried out in a ball mill, and the crushing and mixing time is 15-25 min;
in the step (5), mixing is performed in a granulator.
7. Use of a diflubenzuron premix for veterinary use according to any of claims 1 to 7 in animal feed.
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Citations (4)
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|---|---|---|---|---|
| CN1386507A (en) * | 2001-05-22 | 2002-12-25 | 王玉万 | Compound antiparasitic medicine for fish or full-value feed containing antiparasitic medicine |
| US20130165487A1 (en) * | 2007-12-03 | 2013-06-27 | Valent U.S.A., Corporation | Seed Treatment Formulations |
| CN108902135A (en) * | 2018-06-15 | 2018-11-30 | 刘长德 | A kind of diflubenzuron urea granules and preparation method thereof |
| CN111903701A (en) * | 2020-06-28 | 2020-11-10 | 武汉轻工大学 | Fly-killing premix for animals and preparation method and application thereof |
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2020
- 2020-08-12 CN CN202010804993.3A patent/CN111700863A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1386507A (en) * | 2001-05-22 | 2002-12-25 | 王玉万 | Compound antiparasitic medicine for fish or full-value feed containing antiparasitic medicine |
| US20130165487A1 (en) * | 2007-12-03 | 2013-06-27 | Valent U.S.A., Corporation | Seed Treatment Formulations |
| CN108902135A (en) * | 2018-06-15 | 2018-11-30 | 刘长德 | A kind of diflubenzuron urea granules and preparation method thereof |
| CN111903701A (en) * | 2020-06-28 | 2020-11-10 | 武汉轻工大学 | Fly-killing premix for animals and preparation method and application thereof |
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| Title |
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| 左三龄等: "HPLC法测定兽用除虫脲原料药含量及有关杂质", 《中国兽药杂志》 * |
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Application publication date: 20200925 |