CN111671860A - Antiviral traditional Chinese medicine compound preparation - Google Patents
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Abstract
The invention discloses an antiviral traditional Chinese medicine compound preparation, which belongs to the technical field of traditional Chinese medicines and is prepared from the following substances: astragalus root, pomegranate seed, tree peony bark, loofah sponge, reed rhizome, anemarrhena rhizome, rehmannia root, isatis root, Chinese pulsatilla root and liquorice. The traditional Chinese medicine compound preparation has remarkable antiviral property, is not easy to generate drug resistance, and is safe and stable to use.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to an antiviral traditional Chinese medicine compound preparation.
Background
The cold is a frequently encountered disease, directly affects the life, work and study of people, and especially has serious harm to the health of human bodies caused by influenza viruses. However, because of the strong antigenic variation ability of influenza virus and the difference of individual immunity, the protection rate of the vaccine is not high, moreover, the vaccine only has the preventive effect on known influenza virus subtypes, but has no effect on novel influenza viruses generated by antigenic drift or antigenic conversion. Chemical drugs are also somewhat ineffective against microorganisms that are either of primary or co-viable with human origin. The traditional Chinese medicine has the advantages of low drug resistance, few side effects, few adverse reactions and the like, has the comprehensive effects of inhibiting virus replication, regulating immunologic function, improving blood circulation, relieving fever and pain, resisting bacteria and diminishing inflammation and the like, and has unique advantages and wide development prospect in the aspect of preventing and treating influenza viruses. Therefore, the treatment with traditional Chinese medicines or other natural medicines or their compositions, or other medicines, becomes an important treatment method. In the prior art, a plurality of traditional Chinese medicines or composition preparations thereof for resisting virus have been reported. But the problems of common use effect, slow effect and the like generally exist.
Disclosure of Invention
The invention aims to provide an antiviral traditional Chinese medicine compound preparation.
The technical purpose of the invention is realized by the following technical scheme:
an antiviral traditional Chinese medicine compound preparation is prepared from the following substances in parts by weight:
9-12 parts of astragalus membranaceus, 6-9 parts of pomegranate seeds, 4-6 parts of tree peony bark, 1-3 parts of loofah sponge, 5-8 parts of reed rhizome, 2-4 parts of rhizoma anemarrhenae, 3-6 parts of rehmannia, 10-15 parts of radix isatidis, 5-8 parts of Chinese pulsatilla root and 2-5 parts of liquorice.
Preferably, the food is prepared from the following substances in parts by weight:
8-11 parts of astragalus membranaceus, 7-8 parts of pomegranate seeds, 4.5-5.5 parts of tree peony bark, 1.5-2.5 parts of loofah sponge, 6-7 parts of reed rhizome, 2.5-3.5 parts of rhizoma anemarrhenae, 4-5 parts of rehmannia, 12-14 parts of radix isatidis, 6-7 parts of Chinese pulsatilla root and 3-4 parts of liquorice.
More preferably, the food additive is prepared from the following substances in parts by weight:
10 parts of astragalus membranaceus, 7.5 parts of pomegranate seeds, 5 parts of tree peony bark, 2 parts of loofah sponge, 6.5 parts of reed rhizome, 3 parts of rhizoma anemarrhenae, 4.5 parts of rehmannia, 13 parts of isatis root, 6.5 parts of Chinese pulsatilla root and 3.5 parts of liquorice.
Furthermore, the traditional Chinese medicine composition is prepared by extracting effective medicinal components of astragalus membranaceus, pomegranate seeds, tree peony bark, loofah sponge, reed rhizome, rhizoma anemarrhenae, rehmannia glutinosa, isatis root, Chinese pulsatilla root and liquorice to prepare an extracting agent, and then adding pharmaceutically acceptable auxiliary materials.
Further, the method for extracting the effective medicinal components to prepare the extractant comprises the following steps:
(1) firstly, mixing astragalus membranaceus, pomegranate seeds, tree peony bark, loofah sponge, reed rhizome, rhizoma anemarrhenae, rehmannia, isatis root, Chinese pulsatilla root and liquorice together, and then crushing and sieving by a 60-mesh sieve to obtain mixed powder for later use;
(2) mixing the mixed powder obtained in the step (1) with water, heating and boiling for 2-2.5 h, and filtering to obtain filtrate for later use;
(3) and (3) concentrating the filtrate obtained in the step (2) to obtain the extractant.
Further, the weight ratio of the mixed powder in the step (2) to water is 1: 7-8.
Further, the concentration treatment in the step (3) is to concentrate the filtrate to 20-25% of the original volume.
The common cold is a very common acute infectious respiratory disease caused by viruses. Viruses are the simplest intracellular parasitic microorganisms and must replicate using various biochemical mechanisms of a living cell host. But are somewhat ineffective against microorganisms of this original or human origin that co-exist with them. The traditional Chinese medicine has the advantages of small toxic and side effects, rich medicine sources and low price, has the comprehensive effects of inhibiting virus replication, preventing virus-induced cytopathy, regulating immunity, improving symptoms and the like, and shows unique advantages. A large number of researches show that the traditional Chinese medicine can achieve the purpose of preventing and treating diseases mainly through direct inactivation or virus inhibition and indirect antivirus through inducing interferon or regulating the immune function of a human body.
On the basis, the inventor selects astragalus, pomegranate seeds, tree peony bark, loofah sponge, reed rhizome, rhizoma anemarrhenae, rehmannia, isatis root, Chinese pulsatilla root and liquorice as effective medicinal ingredients, and processes the effective medicinal ingredients to prepare the traditional Chinese medicine compound preparation with good effect.
Compared with the prior art, the invention has the following advantages:
the invention takes astragalus root, pomegranate seed, tree peony bark, loofah sponge, reed rhizome, common anemarrhena rhizome, rehmannia root, indigowoad root, Chinese pulsatilla root and liquoric root as main active substance sources, and the extractant contains rich phenols, flavonoids, saponins, amino acids, alkaloids, lignans, phenylethanoid glycosides, polysaccharides and other components after extraction, and has better water solubility, thereby having exact effect on diseases such as wind-heat type common cold, fever due to pestilence, upper respiratory infection, influenza, parotitis and the like, and being capable of effectively treating the common cold, particularly the wind-heat type common cold. The traditional Chinese medicine compound preparation has remarkable antiviral property, is not easy to generate drug resistance, is safe and stable to use, and has great popularization and application values.
Detailed Description
Example 1
An antiviral traditional Chinese medicine compound preparation is prepared by taking radix astragali, pomegranate seeds, tree peony bark, loofah sponge, reed rhizome, rhizoma anemarrhenae, rehmannia root, isatis root, Chinese pulsatilla root and liquorice as effective medicinal ingredients, extracting to prepare an extracting agent, and then mixing the extracting agent with pharmaceutically acceptable auxiliary materials, wherein the effective medicinal ingredients are prepared from the following components in parts by weight:
9 parts of astragalus membranaceus, 6 parts of pomegranate seeds, 4 parts of tree peony bark, 1 part of loofah sponge, 5 parts of reed rhizome, 2 parts of rhizoma anemarrhenae, 3 parts of rehmannia, 10 parts of isatis root, 5 parts of Chinese pulsatilla root and 2 parts of liquorice.
The method for extracting the effective medicinal components to prepare the extractant comprises the following steps:
(1) firstly, mixing astragalus membranaceus, pomegranate seeds, tree peony bark, loofah sponge, reed rhizome, rhizoma anemarrhenae, rehmannia, isatis root, Chinese pulsatilla root and liquorice together, and then crushing and sieving by a 60-mesh sieve to obtain mixed powder for later use;
(2) mixing the mixed powder obtained in the step (1) with water, heating and boiling for 2 hours, and filtering to obtain filtrate for later use;
(3) and (3) concentrating the filtrate obtained in the step (2) to obtain the extractant.
The corresponding weight ratio of the mixed powder in the step (2) to water is 1:7.
The concentration treatment in step (3) is to concentrate the filtrate to 20% of the original volume.
Example 2
An antiviral traditional Chinese medicine compound preparation is prepared by taking radix astragali, pomegranate seeds, tree peony bark, loofah sponge, reed rhizome, rhizoma anemarrhenae, rehmannia root, isatis root, Chinese pulsatilla root and liquorice as effective medicinal ingredients, extracting to prepare an extracting agent, and then mixing the extracting agent with pharmaceutically acceptable auxiliary materials, wherein the effective medicinal ingredients are prepared from the following components in parts by weight:
8 parts of astragalus membranaceus, 7 parts of pomegranate seeds, 4.5 parts of tree peony bark, 1.5 parts of loofah sponge, 6 parts of reed rhizome, 2.5 parts of rhizoma anemarrhenae, 4 parts of rehmannia, 12 parts of isatis root, 6 parts of Chinese pulsatilla root and 3 parts of liquorice.
The method for extracting the effective medicinal components to prepare the extractant comprises the following steps:
(1) firstly, mixing astragalus membranaceus, pomegranate seeds, tree peony bark, loofah sponge, reed rhizome, rhizoma anemarrhenae, rehmannia, isatis root, Chinese pulsatilla root and liquorice together, and then crushing and sieving by a 60-mesh sieve to obtain mixed powder for later use;
(2) mixing the mixed powder obtained in the step (1) with water, heating and boiling for 2 hours, and filtering to obtain filtrate for later use;
(3) and (3) concentrating the filtrate obtained in the step (2) to obtain the extractant.
The corresponding weight ratio of the mixed powder in the step (2) to water is 1:7.
The concentration treatment in step (3) is to concentrate the filtrate to 20% of the original volume.
Example 3
An antiviral traditional Chinese medicine compound preparation is prepared by taking radix astragali, pomegranate seeds, tree peony bark, loofah sponge, reed rhizome, rhizoma anemarrhenae, rehmannia root, isatis root, Chinese pulsatilla root and liquorice as effective medicinal ingredients, extracting to prepare an extracting agent, and then mixing the extracting agent with pharmaceutically acceptable auxiliary materials, wherein the effective medicinal ingredients are prepared from the following components in parts by weight:
10 parts of astragalus membranaceus, 7.5 parts of pomegranate seeds, 5 parts of tree peony bark, 2 parts of loofah sponge, 6.5 parts of reed rhizome, 3 parts of rhizoma anemarrhenae, 4.5 parts of rehmannia, 13 parts of isatis root, 6.5 parts of Chinese pulsatilla root and 3.5 parts of liquorice.
The method for extracting the effective medicinal components to prepare the extractant comprises the following steps:
(1) firstly, mixing astragalus membranaceus, pomegranate seeds, tree peony bark, loofah sponge, reed rhizome, rhizoma anemarrhenae, rehmannia, isatis root, Chinese pulsatilla root and liquorice together, and then crushing and sieving by a 60-mesh sieve to obtain mixed powder for later use;
(2) mixing the mixed powder obtained in the step (1) with water, heating and boiling for 2.3h, and filtering to obtain filtrate for later use;
(3) and (3) concentrating the filtrate obtained in the step (2) to obtain the extractant.
The corresponding weight ratio of the mixed powder in the step (2) to water is 1: 7.5.
The concentration treatment in step (3) is to concentrate the filtrate to 23% of the original volume.
Example 4
An antiviral traditional Chinese medicine compound preparation is prepared by taking radix astragali, pomegranate seeds, tree peony bark, loofah sponge, reed rhizome, rhizoma anemarrhenae, rehmannia root, isatis root, Chinese pulsatilla root and liquorice as effective medicinal ingredients, extracting to prepare an extracting agent, and then mixing the extracting agent with pharmaceutically acceptable auxiliary materials, wherein the effective medicinal ingredients are prepared from the following components in parts by weight:
11 parts of astragalus membranaceus, 8 parts of pomegranate seeds, 5.5 parts of tree peony bark, 2.5 parts of loofah sponge, 7 parts of reed rhizome, 3.5 parts of rhizoma anemarrhenae, 5 parts of rehmannia, 14 parts of isatis root, 7 parts of Chinese pulsatilla root and 4 parts of liquorice.
The method for extracting the effective medicinal components to prepare the extractant comprises the following steps:
(1) firstly, mixing astragalus membranaceus, pomegranate seeds, tree peony bark, loofah sponge, reed rhizome, rhizoma anemarrhenae, rehmannia, isatis root, Chinese pulsatilla root and liquorice together, and then crushing and sieving by a 60-mesh sieve to obtain mixed powder for later use;
(2) mixing the mixed powder obtained in the step (1) with water, heating and boiling for 2.3h, and filtering to obtain filtrate for later use;
(3) and (3) concentrating the filtrate obtained in the step (2) to obtain the extractant.
The corresponding weight ratio of the mixed powder in the step (2) to water is 1: 7.5.
The concentration treatment in step (3) is to concentrate the filtrate to 23% of the original volume.
Example 5
An antiviral traditional Chinese medicine compound preparation is prepared by taking radix astragali, pomegranate seeds, tree peony bark, loofah sponge, reed rhizome, rhizoma anemarrhenae, rehmannia root, isatis root, Chinese pulsatilla root and liquorice as effective medicinal ingredients, extracting to prepare an extracting agent, and then mixing the extracting agent with pharmaceutically acceptable auxiliary materials, wherein the effective medicinal ingredients are prepared from the following components in parts by weight:
12 parts of astragalus membranaceus, 9 parts of pomegranate seeds, 6 parts of tree peony bark, 3 parts of loofah sponge, 8 parts of reed rhizome, 4 parts of rhizoma anemarrhenae, 6 parts of rehmannia, 15 parts of isatis root, 8 parts of Chinese pulsatilla root and 5 parts of liquorice.
The method for extracting the effective medicinal components to prepare the extractant comprises the following steps:
(1) firstly, mixing astragalus membranaceus, pomegranate seeds, tree peony bark, loofah sponge, reed rhizome, rhizoma anemarrhenae, rehmannia, isatis root, Chinese pulsatilla root and liquorice together, and then crushing and sieving by a 60-mesh sieve to obtain mixed powder for later use;
(2) mixing the mixed powder obtained in the step (1) with water, heating and boiling for 2.5 hours, and filtering to obtain filtrate for later use;
(3) and (3) concentrating the filtrate obtained in the step (2) to obtain the extractant.
The corresponding weight ratio of the mixed powder in the step (2) to water is 1: 8.
The concentration treatment in step (3) is to concentrate the filtrate to 25% of the original volume.
Comparative example 1
This comparative example 1 is different from example 3 only in that the use of the moutan bark component is omitted except that the process steps are the same.
Comparative example 2
This comparative example 2 is different from example 3 only in that the use of the vegetable sponge component is omitted except that the process steps are the same.
In order to compare the effects of the invention, the performance test of the Chinese herbal compound preparations prepared in the above example 3, comparative example 1 and comparative example 2 was performed, specifically, the in vitro bacteriostasis test was performed by using a plate method: taking nutrient broth culture of each strain cultured for 18 hr, and using the nutrient broth as 10-3Diluting and adding 1ml of bacteria solution into a sterilized plate with a diameter of 9cm, adding 20ml of nutrient agar culture medium which is melted and cooled to 45 ℃, uniformly rotating, freezing, punching the plate with a sterilized steel tube with a diameter of 6mm, taking out the culture medium from the holes with sterile forceps, and adding the bacteria solution of example 3 into each hole,The extraction agents prepared in comparative examples 1 and 2 are prepared into liquid medicine with the concentration of 0.5g/ml, 0.1g/ml Shuanghuanglian medicament is added as a control group 1, the liquid medicine is finally cultured at 37 ℃ for 20 hours, a plate is taken out, the diameter of a bacteriostatic circle is measured and repeated for 3 times, and the experimental average value is obtained, and the results are shown in the following table 1:
TABLE 1
In order to further compare the effects of the invention, the performance test of the Chinese herbal compound preparations prepared in the above example 3, comparative example 1 and comparative example 2 was carried out, specifically, an in vivo bacteriostasis test was carried out, and 18-20 g of Kunming mice 120 were divided into six groups at random, each group having 20 mice for both male and female. Setting a blank control group, a model control group, a control group 2, and the above-mentioned groups of example 3, comparative example 1 and comparative example 2, wherein the blank control group is not infected and is fed with physiological saline correspondingly, the model control group is fed with physiological saline correspondingly, the control group 2 is fed with solution of Shuanghuanglian (0.2g/ml) correspondingly, the groups of example 3, comparative example 1 and comparative example 2 are fed with liquid medicine prepared by using the prepared extractant with corresponding feeding, the concentration of the liquid medicine is 0.8g/ml, the mice in the above groups are administered by gastric lavage, the gastric lavage volume is 20ml/kg, 1 time/day is multiplied by 6 days, after 1 hour of administration on day 3, 0.5ml of staphylococcus aureus liquid is injected into the abdominal cavity of each mouse (except the blank control group), administration is continued for 3 days, the death condition of each group of animals within 7 days is observed, and the results are shown in the following table 2:
TABLE 2
In conclusion, the Chinese medicinal compound preparation has remarkable antiviral effect and extremely high popularization and application values.
Claims (7)
1. An antiviral traditional Chinese medicine compound preparation is characterized by being prepared from the following substances in parts by weight:
9-12 parts of astragalus membranaceus, 6-9 parts of pomegranate seeds, 4-6 parts of tree peony bark, 1-3 parts of loofah sponge, 5-8 parts of reed rhizome, 2-4 parts of rhizoma anemarrhenae, 3-6 parts of rehmannia, 10-15 parts of radix isatidis, 5-8 parts of Chinese pulsatilla root and 2-5 parts of liquorice.
2. The antiviral traditional Chinese medicine compound preparation according to claim 1, which is characterized by being prepared from the following substances in parts by weight:
8-11 parts of astragalus membranaceus, 7-8 parts of pomegranate seeds, 4.5-5.5 parts of tree peony bark, 1.5-2.5 parts of loofah sponge, 6-7 parts of reed rhizome, 2.5-3.5 parts of rhizoma anemarrhenae, 4-5 parts of rehmannia, 12-14 parts of radix isatidis, 6-7 parts of Chinese pulsatilla root and 3-4 parts of liquorice.
3. The antiviral traditional Chinese medicine compound preparation according to claim 2, which is characterized by being prepared from the following substances in parts by weight:
10 parts of astragalus membranaceus, 7.5 parts of pomegranate seeds, 5 parts of tree peony bark, 2 parts of loofah sponge, 6.5 parts of reed rhizome, 3 parts of rhizoma anemarrhenae, 4.5 parts of rehmannia, 13 parts of isatis root, 6.5 parts of Chinese pulsatilla root and 3.5 parts of liquorice.
4. The antiviral traditional Chinese medicine compound preparation according to any one of claims 1 to 3, which is characterized in that the antiviral traditional Chinese medicine compound preparation is prepared by taking radix astragali, pomegranate seed, tree peony bark, loofah sponge, reed rhizome, rhizoma anemarrhenae, rehmannia root, radix isatidis, Chinese pulsatilla root and liquorice as effective medicinal ingredients, extracting to prepare an extracting agent, and then adding pharmaceutically acceptable auxiliary materials.
5. The antiviral traditional Chinese medicine compound preparation as claimed in claim 4, wherein the method for extracting the effective pharmaceutical ingredients to prepare the extractant comprises the following steps:
(1) firstly, mixing astragalus membranaceus, pomegranate seeds, tree peony bark, loofah sponge, reed rhizome, rhizoma anemarrhenae, rehmannia, isatis root, Chinese pulsatilla root and liquorice together, and then crushing and sieving by a 60-mesh sieve to obtain mixed powder for later use;
(2) mixing the mixed powder obtained in the step (1) with water, heating and boiling for 2-2.5 h, and filtering to obtain filtrate for later use;
(3) and (3) concentrating the filtrate obtained in the step (2) to obtain the extractant.
6. The antiviral traditional Chinese medicine compound preparation according to claim 5, wherein the weight ratio of the mixed powder in the step (2) to water is 1: 7-8.
7. The antiviral compound traditional Chinese medicine preparation according to claim 5, wherein the concentration treatment in the step (3) is to concentrate the filtrate to 20-25% of the original volume.
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| CN202010717726.2A CN111671860A (en) | 2020-07-23 | 2020-07-23 | Antiviral traditional Chinese medicine compound preparation |
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Application publication date: 20200918 |