CN111671815A - A medicine with antipruritic effect, and its preparation method - Google Patents
A medicine with antipruritic effect, and its preparation method Download PDFInfo
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Abstract
The invention relates to a medicine with an antipruritic effect and a preparation method thereof, wherein the medicine with the antipruritic effect comprises the following raw materials in parts by weight: 600 portions of alangium platanifolium, 600 portions of broussonetia papyrifera, 400 portions of Sophora flavescens, 600 portions of willow leaves and 200 portions of salt. The invention has the beneficial effects that: the medicine with the effect of relieving itching has better effects of dispelling wind, eliminating dampness, relieving itching, relieving pain, promoting granulation and preventing corrosion. The traditional Chinese medicine composition is used for treating various tinea, eczema, diabetic foot, bedsore, senile skin pruritus and the like, can obviously relieve the skin pruritus symptom, and is quick in effect taking, simple in preparation method, convenient to use, high in safety, wide in adaptability, free of drug dependence and suitable for popularization and utilization.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a medicine with an itching relieving effect and a preparation method thereof.
Background
Pruritus is a dermatological condition in which there is only itching of the skin and no primary skin lesions. Simple skin diseases such as dermatitis, eczema or psoriasis, skin allergy, gynecological diseases such as infection with germs such as trichomonas, candida albicans, etc., liver and gall diseases, diabetes, thyroid diseases, malignant tumors, etc. can cause skin pruritus. The existing medicines for treating skin itch comprise external surface anesthetics, antihistamines, immunosuppressants, glucocorticoids and the like, have a certain relieving effect on the localized itch, but are easy to generate drug dependence, the using effect can be gradually weakened, and the skin itch is easy to relapse after stopping taking the medicines.
Disclosure of Invention
The invention aims to provide a medicine with an itching relieving effect, which has the advantages of obvious itching relieving curative effect, quick response, high safety, wide adaptability, convenient use and difficult relapse after stopping medicine, and a preparation method thereof.
The technical scheme of the invention is as follows:
a medicine with an itching relieving effect comprises the following raw materials in parts by weight: 600 portions of alangium platanifolium, 600 portions of broussonetia papyrifera, 400 portions of Sophora flavescens, 600 portions of willow leaves and 200 portions of salt. Preferably, the medicine with the effect of relieving itching comprises the following raw materials in parts by weight: 550 parts of alangium platanifolium, 550 parts of broussonetia papyrifera, 350 parts of radix sophorae flavescentis, 550 parts of willow leaf and 120 parts of salt. More preferably, the medicine with the effect of relieving itching comprises the following raw materials in parts by weight: 500 parts of Chinese alangium, 500 parts of broussonetia papyrifera leaves, 300 parts of radix sophorae flavescentis, 500 parts of willow leaves and 150 parts of salt. Preferably, the medicine with the effect of relieving itching also comprises the following raw materials in parts by weight: 150 parts of brown sugar, 150 parts of white sugar and 100 parts of dragon's blood.
The Chinese alangium root adopted by the invention has the functions of dispelling wind and eliminating dampness, relaxing tendons and activating collaterals, dissipating blood stasis and relieving pain, removing heat from folium broussonetiae, cooling blood, promoting diuresis and killing parasites, and the sophora flavescens has the functions of removing heat and eliminating dampness and killing parasites, and the salix leaves have the functions of clearing heat, relieving swelling and pain and promoting eruption, and the salt is used for disinfecting and preventing corrosion.
Modern pharmacological research shows that the Chinese alangium contains physiologically active components such as octagon and the like, has the function of resisting local inflammation of mice induced by chemical substances, and has the effect of inhibiting and killing pathogenic bacteria such as staphylococcus aureus, pseudomonas aeruginosa and the like. The Broussonetia papyrifera leaves are leaves of Broussonetia papyrifera (L.) Vent of Broussonetia of Moraceae, contain abundant flavonoids, have pharmacological effects of bacteriostasis, anti-inflammation, antioxidation and the like, and also have a certain anti-platelet aggregation effect. The sophora flavescens contains matrine and various alkaloid components, can reduce the release of organism allergic media, further has the antiallergic effect, and simultaneously has certain inhibition effect on the respiration and nucleic acid metabolism of bacteria, dysentery bacillus, proteus and staphylococcus aureus. In addition, the parasite killing agent also has the effects of paralysis on the nervous system of the parasite, losing adhesion and vitality, and expelling the parasite out of the body along with metabolic waste, thereby achieving the effect of expelling parasites. The willow leaf mainly contains tannin (4.93%), salicin and flavonoid compounds, wherein the tannin has the effects of astringing and promoting wound healing; the salicin can be combined with amino acid of protein to play the role of anti-fungus; the flavonoids have antibacterial, antiinflammatory, antiallergic and immunity enhancing effects. Modern researches believe that the occurrence of pruritus is mainly caused by the release of chemical mediators such as histamine, P substances, kinins, protease and the like, and the antipruritic medicament contains rich physiologically active substances such as alkaloid, flavonoid and the like, has better anti-inflammatory and bactericidal effects and thus has better antipruritic effect.
The invention also provides a preparation method of the medicine with the effect of relieving itching, which comprises the following steps:
(1) weighing the raw materials in parts by weight for later use;
(2) mixing the raw materials, adding water for soaking, decocting, and filtering to obtain a decoction; preferably, the mass ratio of the total amount of the mixed raw materials to water is 1:4-6, and the soaking time is 1-3 h. After soaking, in order to fully extract the effective components of the medicinal materials, decocting for 3 times, specifically, decocting for the first time; adding water 2-3 times the weight of the pure medicinal materials into the residue after the first decoction for second decoction; and then adding water with the weight 2-3 times of that of the pure medicinal materials into the residues obtained after the second decoction for the third decoction, combining the decoctions for the third time, and then filtering. The decoction is carried out by boiling with strong fire and then decocting with slow fire, the time for the first decoction is 1-2h, the time for the second decoction is 2-3h, and the time for the third decoction is 1-2 h. The time for the first decoction is 1.5 hours, the time for the second decoction is 2.5 hours, and the time for the third decoction is 1.5 hours.
(3) And (3) heating and concentrating the decoction, wherein the heating and concentrating are preferably carried out at the temperature of 80-90 ℃ until the volume is reduced by more than 1/2, so as to obtain the Chinese medicinal composition.
The invention has the beneficial effects that:
the medicine with the effect of relieving itching has better effects of dispelling wind, eliminating dampness, relieving itching, relieving pain, promoting granulation and preventing corrosion. The traditional Chinese medicine composition is used for treating various tinea, eczema, diabetic foot, bedsore, senile skin pruritus and the like, can obviously relieve the skin pruritus symptom, and is quick in effect taking, simple in preparation method, convenient to use, high in safety, wide in adaptability, free of drug dependence and suitable for popularization and utilization.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely a few embodiments of the invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention. In the following examples, 1 part by weight represents 1 g.
Example 1
The embodiment provides a medicine with an itching relieving effect, which is prepared from the following raw materials in parts by weight:
400 parts of Chinese alangium, 600 parts of broussonetia papyrifera leaves, 200 parts of radix sophorae flavescentis, 600 parts of willow leaves and 100 parts of salt.
The preparation method comprises the following steps:
(1) weighing the raw materials in parts by weight for later use;
(2) mixing the raw materials, adding water with the weight 4 times that of the mixed raw materials, soaking for 1 hour, boiling with strong fire, and decocting with slow fire for 1 hour; adding water 2 times the weight of the pure medicinal materials into the decocted residues, boiling with strong fire, and decocting with slow fire for 2 h; adding water 2 times the weight of the pure medicinal materials into the residues obtained after the second decoction, decocting the residues with strong fire for 1 hour with slow fire, combining the decoctions obtained in the three times, and filtering;
(3) concentrating the decoction at 80 deg.C until the volume is reduced to 1/2, packaging with honey under aseptic condition, and sealing.
Example 2
The embodiment provides a medicine with an itching relieving effect, which is prepared from the following raw materials in parts by weight:
600 parts of Chinese alangium, 400 parts of broussonetia papyrifera leaves, 400 parts of radix sophorae flavescentis, 400 parts of willow leaves and 200 parts of salt.
The preparation method comprises the following steps:
(1) weighing the raw materials in parts by weight for later use;
(2) mixing the raw materials, adding water with the weight 6 times that of the mixed raw materials, soaking for 3 hours, boiling with strong fire, and decocting with slow fire for 2 hours; adding 3 times of water into the decocted residue, boiling with strong fire, and decocting with slow fire for 3 h; adding 3 times of water into the residue after the second decoction, decocting with strong fire for 2 hr, mixing the decoctions, and filtering;
(3) concentrating the decoction at 90 deg.C until the volume is reduced to 1/2, packaging with honey under aseptic condition, and sealing.
Example 3
The embodiment provides a medicine with an itching relieving effect, which is prepared from the following raw materials in parts by weight:
450 parts of Chinese alangium, 550 parts of broussonetia papyrifera leaves, 250 parts of radix sophorae flavescentis, 550 parts of willow leaves and 120 parts of salt.
The preparation method comprises the following steps:
(1) weighing the raw materials in parts by weight for later use;
(2) mixing the raw materials, adding water with the weight 5 times that of the mixed raw materials, soaking for 2 hours, boiling with strong fire, and then decocting with slow fire for 1.5 hours; adding 3 times of water into the decocted residue, boiling with strong fire, and decocting with slow fire for 2.5 h; adding 2 times of water into the residue after the second decoction, decocting with strong fire for 1.5h, mixing the decoctions, and filtering;
(3) concentrating the decoction at 80 deg.C until the volume is reduced to 1/2, packaging with honey under aseptic condition, and sealing.
Example 4
The embodiment provides a medicine with an itching relieving effect, which is prepared from the following raw materials in parts by weight:
550 parts of Chinese alangium, 450 parts of broussonetia papyrifera leaves, 350 parts of radix sophorae flavescentis, 450 parts of willow leaves and 180 parts of salt.
The preparation method comprises the following steps:
(1) weighing the raw materials in parts by weight for later use;
(2) mixing the raw materials, adding water with the weight 5 times that of the mixed raw materials, soaking for 2 hours, boiling with strong fire, and then decocting with slow fire for 1.5 hours; adding 3 times of water into the decocted residue, boiling with strong fire, and decocting with slow fire for 2.5 h; adding 2 times of water into the residue after the second decoction, decocting with strong fire for 1.5h, mixing the decoctions, and filtering;
(3) concentrating the decoction at 80 deg.C until the volume is reduced to 1/2, packaging with honey under aseptic condition, and sealing.
Example 5
The embodiment provides a medicine with an itching relieving effect, which is prepared from the following raw materials in parts by weight:
500 parts of Chinese alangium, 500 parts of broussonetia papyrifera leaves, 300 parts of radix sophorae flavescentis, 500 parts of willow leaves and 150 parts of salt.
The preparation method comprises the following steps:
(1) weighing the raw materials in parts by weight for later use;
(2) mixing the raw materials, adding water with the weight 5 times that of the mixed raw materials, soaking for 2 hours, boiling with strong fire, and then decocting with slow fire for 1.5 hours; adding 3 times of water into the decocted residue, boiling with strong fire, and decocting with slow fire for 2.5 h; adding 2 times of water into the residue after the second decoction, decocting with strong fire for 1.5h, mixing the decoctions, and filtering;
(3) concentrating the decoction at 80 deg.C until the volume is reduced to 1/2, packaging with honey under aseptic condition, and sealing.
Example 6
The embodiment provides a medicine with an itching relieving effect, which is prepared from the following raw materials in parts by weight:
500 parts of Chinese alangium, 500 parts of broussonetia papyrifera leaves, 300 parts of radix sophorae flavescentis, 500 parts of willow leaves, 150 parts of salt, 150 parts of brown sugar, 150 parts of white sugar and 100 parts of dragon's blood.
The preparation method comprises the following steps:
(1) weighing the raw materials in parts by weight for later use;
(2) mixing the raw materials, adding water with the weight 5 times that of the mixed raw materials, soaking for 2 hours, boiling with strong fire, and then decocting with slow fire for 1.5 hours; adding 3 times of water into the decocted residue, boiling with strong fire, and decocting with slow fire for 2.5 h; adding 2 times of water into the residue after the second decoction, decocting with strong fire for 1.5h, mixing the decoctions, and filtering;
(3) concentrating the decoction at 80 deg.C until the volume is reduced to 1/2, packaging with honey under aseptic condition, and sealing.
Comparative example
The broussonetia papyrifera leaves are removed on the basis of example 4, and specifically, the comparative example is prepared from the following raw materials in parts by weight: 500 parts of Chinese alangium, 300 parts of radix sophorae flavescentis, 1000 parts of willow leaves and 150 parts of salt. The preparation method is the same as example 4.
The invention researches the itching relieving effect of histamine phosphate induced foot itch of rats
1. Test animals: wistar male rat 5O, body weight 180-220 g.
2. The test method comprises the following steps: all rats were randomly divided into 5 groups of blank control group, example 5 group, example 6 group, comparative example group and positive control group, each group had 10 rats, the right and back paw of each group was dehaired, then the drug was applied, the blank control group was wet-dressed on the dehaired part with physiological saline, the positive control group was wet-dressed on the dehaired part with calamine lotion, the remaining groups were wet-dressed with the drugs of the respective groups, and each group was wet-dressed for 40 min. Then, 50 mu l/paw of histamine phosphate of 0.01% is dripped at the wet dressing part, and then, the histamine phosphate is dripped in an equal amount once every 3min, the concentration of each dripping is gradually increased according to 0.02%, 0.03% and 0.04% in sequence until the rat licks the feet, and the total amount of the dripping histamine phosphate is recorded as the scratchiness threshold.
3. The test results are shown in Table 1.
TABLE 1
Group of | Threshold of itch/μ g |
Blank control group | 25.63±8.14 |
EXAMPLE 5 group | 313.92±30.26**# |
EXAMPLE 6 group | 317.47±34.15**# |
Comparative example group | 234.80±28.03** |
Positive control group | 220.54±25.75** |
Compared with the blank control group, the ratio of the active ingredients,**p<0.01, compared with the positive control group,#p<0.05。
the results show that the antipruritic medicine groups in the 5 and 6 have higher itching-causing threshold which is obviously superior to that of a blank control group (p <0.01) and a positive control group (p <0.05), and the antipruritic effect of the antipruritic medicine is obvious.
Clinical study of the antipruritic Effect of the invention
Selecting 30 eczema patients of 10-50 years old, selecting skin damage as polymorphism, mainly erythema, pimple and herpes simplex, wherein the central part of the rash is obvious, gradually disperses to the periphery, is unclear, is diffuse and has exudation tendency, and chronic patients have infiltration and hypertrophy. The disease course is irregular, and the itching is severe with repeated attacks. All patients were randomized into 3 groups of 10 persons each, using example 5, example 6 and a commercial soothing antipruritic lotion, respectively, using the following methods: uniformly spraying onto skin injury part, massaging to absorb, and administering in the morning, at noon and evening for 3 days. The judgment standard of the curative effect is as follows: and (4) invalidation: the skin itching sensation was unchanged from before; the method has the following advantages: the skin itch sensation is slightly relieved compared with the prior art; the effect is shown: the skin itching sensation is significantly reduced compared to before.
The statistical result shows that the groups of the invention in the 5 and 6 are respectively 8 effective persons and 2 effective persons, the effective rate is 100%, while the group of the commercially available relieving itching lotion is 4 effective persons and 3 effective persons, the effective rate is only 70%, which shows that the itching relieving effect of the invention is obviously superior to that of the commercially available product.
The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.
Claims (10)
1. The medicine with the effect of relieving itching is characterized by comprising the following raw materials in parts by weight: 600 portions of alangium platanifolium, 600 portions of broussonetia papyrifera, 400 portions of Sophora flavescens, 600 portions of willow leaves and 200 portions of salt.
2. The antipruritic drug according to claim 1, which comprises the following raw materials in parts by weight: 550 parts of alangium platanifolium, 550 parts of broussonetia papyrifera, 350 parts of radix sophorae flavescentis, 550 parts of willow leaf and 120 parts of salt.
3. The antipruritic drug according to claim 1, which comprises the following raw materials in parts by weight: 500 parts of Chinese alangium, 500 parts of broussonetia papyrifera leaves, 300 parts of radix sophorae flavescentis, 500 parts of willow leaves and 150 parts of salt.
4. The antipruritic drug according to claim 3, further comprising the following raw materials in parts by weight: 150 parts of brown sugar, 150 parts of white sugar and 100 parts of dragon's blood.
5. A process for the preparation of a medicament with antipruritic effect according to any one of claims 1 to 4, comprising the steps of:
(1) weighing the raw materials in parts by weight for later use;
(2) mixing the raw materials, adding water for soaking, decocting, and filtering to obtain a decoction;
(3) and heating and concentrating the decoction to obtain the Chinese medicinal composition.
6. The preparation method according to claim 5, wherein in the step (2), the mass ratio of the total amount of the mixed raw materials to water is 1:4-6, and the soaking time is 1-3 h.
7. The preparation method according to claim 5, wherein in the step (2), after soaking, the first decoction is carried out; adding water 2-3 times the weight of the pure medicinal materials into the residue after the first decoction for second decoction; and then adding water with the weight 2-3 times of that of the pure medicinal materials into the residues obtained after the second decoction for the third decoction, combining the decoctions for the third time, and then filtering.
8. The preparation method of claim 7, wherein the decoction is carried out by boiling with strong fire and then decocting with slow fire, the time for the first decoction is 1-2h, the time for the second decoction is 2-3h, and the time for the third decoction is 1-2 h.
9. The method of claim 8, wherein the first decoction is carried out for 1.5 hours, the second decoction is carried out for 2.5 hours, and the third decoction is carried out for 1.5 hours.
10. The method of claim 5, wherein the heat concentration is carried out at 80-90 ℃ to a volume reduction of 1/2 or more.
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CN (1) | CN111671815A (en) |
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2020
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