CN111671711A - Bacteriostatic hand sanitizer for children and preparation method thereof - Google Patents
Bacteriostatic hand sanitizer for children and preparation method thereof Download PDFInfo
- Publication number
- CN111671711A CN111671711A CN202010762270.1A CN202010762270A CN111671711A CN 111671711 A CN111671711 A CN 111671711A CN 202010762270 A CN202010762270 A CN 202010762270A CN 111671711 A CN111671711 A CN 111671711A
- Authority
- CN
- China
- Prior art keywords
- children
- hand sanitizer
- zingiber mioga
- extract
- bacteriostatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
Abstract
The invention discloses a bacteriostatic hand sanitizer for children and a preparation method thereof. The bacteriostatic hand sanitizer for children comprises the following components in percentage by weight: 5.0-15.0% of surfactant, 1.0-3.0% of glycerol, 0.02-0.1% of EDTA-2Na, 0.05-0.2% of vitamin E, 2.0-7.0% of Zingiber mioga extract and the balance of deionized water. The Zingiber mioga ginger extract is Zingiber mioga ginger polysaccharide which has a bacteriostatic natural effect and is added into the hand sanitizer for children as a green, safe and mild bacteriostatic agent. When the hand sanitizer is used for washing hands, the polysaccharide forms an antibacterial protective layer on the surface of the palm, can inhibit the propagation of harmful microorganisms such as bacteria and the like, and prevents children from entering the mouth.
Description
Technical Field
The invention belongs to a hand sanitizer, belongs to the technical field of daily chemical articles, and particularly relates to a bacteriostatic hand sanitizer for children and a preparation method thereof.
Background
Harmful bacteria and viruses in the environment can easily enter the human body through the oral cavity after contacting the human body by hands, thereby causing gastrointestinal diseases and even epidemic infectious diseases. Thus, hard washing of hands is an important measure to effectively prevent "sickness from entering the mouth". The soap is used for washing hands traditionally, and a plurality of people share one soap, so that the risk of cross infection exists, and the hand sanitizer gradually replaces the soap to become the first choice for cleaning hands of consumers due to convenient and sanitary use.
At present, hand sanitizer for children in the market is various in variety, but the main functions are mostly focused on hand cleaning, and for the problems that hands of children are easy to contact with bacteria and breed the bacteria, products with the bacteriostatic function are still rare.
On one hand, chemically synthesized bacteriostats may have allergic reactions to the skin of children, and therefore, the addition amount of the chemically synthesized bacteriostats in the hand sanitizer products for children has strict requirements.
On the other hand, the traditional 75% alcohol disinfectant has better effect of killing bacteria and viruses. However, the skin of children is not completely developed and has weak protective effect, and high-concentration alcohol solution easily causes skin dehydration, and causes side effects such as dry skin and desquamation.
Therefore, for research and development personnel in the industry, the development of a natural, safe and mild bacteriostatic hand sanitizer for children is an urgent problem to be solved, and has wide market demand.
Disclosure of Invention
The invention aims to provide a bacteriostatic hand sanitizer for children, which is prepared by extracting polysaccharide from zingiber mioga ginger by using a modern extraction and separation technology and then adding the polysaccharide into the hand sanitizer for children according to a specific process, and has a good using effect on protecting the body health of children and preventing diseases from entering the mouth.
The invention also aims to provide a preparation method of the hand sanitizer with antibacterial effect for children, after the hand sanitizer is used, the growth and the propagation of harmful bacteria on hands of children are inhibited, and the sanitation of the hands is kept.
The technical scheme adopted by the invention is as follows:
the bacteriostatic hand sanitizer for children consists of the following components in percentage by weight:
5.0-15.0% of surfactant, 1.0-3.0% of glycerol, 0.02-0.1% of EDTA-2Na, 0.05-0.2% of vitamin E, 2.0-7.0% of Zingiber mioga extract and the balance of deionized water.
Further, the bacteriostatic hand sanitizer for children comprises the following components in percentage by weight:
7.0-12.0% of surfactant, 1.5-2.0% of glycerol, 0.02-0.05% of EDTA-2Na, 0.1-0.15% of vitamin E, 3.5-5.5% of Zingiber mioga extract and the balance of deionized water.
Further, the surfactant is selected from one or more of sodium laureth sulfate, sodium cocoyl amphoacetate, sodium lauroyl sarcosinate, cocamidopropyl betaine, laureth-5-carboxylic acid, sodium methylcocoyl taurate, sodium cocoyl isethionate, and sodium lauroyl glutamate.
Further, the extraction process of the zingiber mioga ginger extract comprises the following steps:
1) drying and crushing a Zingiber mioga plant, and sieving the crushed Zingiber mioga plant through a standard sieve with 10-30 meshes to obtain dry Zingiber mioga powder;
2) adding mioga ginger dry powder into an ethanol water solution with volume fraction of 50%, wherein the material-liquid ratio is 1: 10-20 ℃, wherein the extraction temperature is 70-90 ℃, reflux extraction is carried out for 2-5 hours, after the extraction is finished, filtration is carried out to obtain filtrate, ethanol is removed by reduced pressure distillation, and drying is continued at 80-90 ℃ to obtain a zingiber mioga crude extract;
3) taking a mioga ginger crude extract in a material-liquid ratio of 1: 15-20, adding water, stirring for 30 minutes, dissolving, and separating and purifying by using a PEG 6000/ammonium sulfate two-aqueous-phase system: extraction temperature: and (3) stirring at 40-50 ℃ for: 40-60 minutes; standing;
4) after extraction is finished, collecting an inorganic salt lower phase, filtering and concentrating by using an ultrafiltration membrane, intercepting a polysaccharide solution with molecular weight of 3-20 kDa, and freeze-drying to obtain the Zingiber mioga ginger extract;
further, the Zingiber mioga extract is Zingiber mioga polysaccharide.
Further, the molecular weight of the PEG is 400-6000, and the PEG accounts for 10-30% of the mass of the system;
the ammonium sulfate accounts for 15-30% of the mass of the system;
the vitamin E group comprises: vitamin E and its derivative compounds.
In addition, the invention also discloses a preparation method of the bacteriostatic hand sanitizer for children, which comprises the following steps:
1) heating deionized water accounting for 30% of the formula amount to 80-85 ℃, sequentially adding a surfactant and glycerol, and stirring for 30min under heat preservation;
2) and (3) supplementing the rest deionized water in the formula, cooling to 40-45 ℃, adding EDTA-2Na, vitamin E and the Zingiber mioga ginger extract (firstly, dissolving with a small amount of deionized water), and continuously stirring for 30min to obtain the finished product.
By means of the technical scheme, the invention has the following advantages and beneficial effects:
1) in the process of researching the zingiber mioga extract, the inventor researches extracts with biological activity, such as flavones, polysaccharides and the like in the zingiber mioga, and surprisingly discovers that the zingiber mioga polysaccharide has an inhibiting effect on various harmful bacteria and fungi.
The antibacterial hand sanitizer for children prepared by extracting polysaccharide from the mioga ginger by using a modern extraction and separation technology and then adding the polysaccharide into the hand sanitizer for children according to a specific process has a good using effect on protecting the health of children and preventing diseases from entering the mouth.
2) The invention provides an extraction preparation process of Zingiber mioga ginger polysaccharide, which is used as a green, safe and mild bacteriostatic agent, and can be added into cosmetics to endow the cosmetics with bacteriostatic effect; the mioga ginger polysaccharide is added into the hand sanitizer for children, and after the hand sanitizer is used for washing hands, the polysaccharide forms an antibacterial protective layer on the surface of palms, so that the propagation of harmful microorganisms such as antibacterial bacteria and the like can be realized, and the body health of children is protected.
Drawings
Figure 1 is an infrared scanning atlas of zingiber mioga ginger extract.
Detailed Description
The present invention will be described in more detail below with reference to specific preferred embodiments and examples of effects, but the present invention is not limited to the following examples.
In the following examples, the percentages referred to are by weight unless otherwise indicated.
The invention discloses a bacteriostatic hand sanitizer for children and a preparation method thereof. The bacteriostatic hand sanitizer for children consists of the following components in percentage by weight: 5.0-15.0% (preferably 7.0-12.0%) of surfactant, 1.0-3.0% (preferably 1.5-2.0%) of glycerol, 0.02-0.1% (preferably 0.02-0.05%) of EDTA-2Na, 0.05-0.2% (preferably 0.1-0.15%) of vitamin E, 2.0-7.0% (preferably 3.5-5.5%) of Zingiber mioga extract, and the balance of deionized water.
The Zingiber mioga ginger extract is Zingiber mioga ginger polysaccharide which has a bacteriostatic natural effect and is added into the hand sanitizer for children as a green, safe and mild bacteriostatic agent. When the hand sanitizer is used for washing hands, the polysaccharide forms an antibacterial protective layer on the surface of the palm, can inhibit the propagation of harmful microorganisms such as bacteria and the like, and prevents children from entering the mouth.
Zingiber mioga Rosc (Zingiber mioga Rosc) is a perennial herb of Zingiberaceae, and has medicinal root, stem, flower and leaf, and has effects of promoting blood circulation, regulating menstruation, eliminating phlegm, relieving cough, removing toxic substance, relieving swelling, resolving food stagnation, invigorating stomach, warming spleen and stomach, regulating qi-flowing, etc., and can be used for treating various diseases. Zingiber mioga is widely distributed in Anhui, Jiangsu, Zhejiang, Hunan, Jiangxi, Guangdong, Guangxi, Yunnan, Guizhou and other places in China, and has a long use history in China.
In the research process of the zingiber mioga ginger activity extract, researchers study active ingredients in the zingiber mioga ginger: flavones, polysaccharides and the like are found to have various biological activities, particularly the Zingiber mioga ginger polysaccharide has an inhibiting effect on various harmful bacteria and fungi, and the polysaccharide in the Zingiber mioga ginger is extracted by utilizing a modern separation and extraction technology, so that comprehensive development and utilization are the hotspots of the current research.
In the process of researching the zingiber mioga extract, the inventor researches extracts with biological activity, such as flavones, polysaccharides and the like in the zingiber mioga, and surprisingly discovers that the zingiber mioga polysaccharide has an inhibiting effect on various harmful bacteria and fungi.
The following examples 1-3 are preparation examples of the Zingiber mioga extract of the present invention, and examples 4-6 are formulation and preparation of the composition.
Example 1
The preparation method of the Zingiber mioga ginger extract comprises the following steps:
1) drying and crushing 2000g of Zingiber mioga plants, and sieving the crushed Zingiber mioga plants through a standard sieve of 20 meshes to obtain dry Zingiber mioga powder;
2) adding mioga ginger dry powder into an ethanol water solution with volume fraction of 50%, wherein the material-liquid ratio is 1: 10, extracting at 85 ℃ under reflux for 5 hours, filtering to obtain filtrate, distilling under reduced pressure to remove ethanol, and continuously drying at 90 ℃ to obtain a zingiber mioga crude extract;
3) taking a mioga ginger crude extract in a material-liquid ratio of 1: 15, adding water, stirring for 30 minutes, dissolving, and separating and purifying by using a PEG 6000/ammonium sulfate aqueous two-phase system: extraction temperature: 45 ℃, stirring time: 60 minutes; standing;
4) and (3) after extraction, collecting an inorganic salt lower phase, filtering and concentrating by using an ultrafiltration membrane, intercepting a polysaccharide solution with molecular weight of 3-20 kDa, and freeze-drying to obtain the Zingiber mioga ginger extract.
Example 2
The preparation method of the Zingiber mioga ginger extract comprises the following steps:
1) drying and crushing 1000g of Zingiber mioga plants, and sieving the crushed Zingiber mioga plants through a standard sieve of 20 meshes to obtain dry Zingiber mioga powder;
2) adding mioga ginger dry powder into an ethanol water solution with volume fraction of 50%, wherein the material-liquid ratio is 1: 8, extracting at 88 ℃ for 4.5 hours under reflux, filtering to obtain filtrate, distilling under reduced pressure to remove ethanol, and continuously drying at 90 ℃ to obtain a zingiber mioga crude extract;
3) taking a mioga ginger crude extract in a material-liquid ratio of 1: 18, adding water, stirring for 30 minutes, dissolving, and separating and purifying by using a PEG 6000/ammonium sulfate aqueous two-phase system: extraction temperature: 45 ℃, stirring time: 60 minutes; standing;
4) and (3) after extraction, collecting an inorganic salt lower phase, filtering and concentrating by using an ultrafiltration membrane, intercepting a polysaccharide solution with molecular weight of 3-20 kDa, and freeze-drying to obtain the Zingiber mioga ginger extract.
Example 3
The preparation method of the Zingiber mioga ginger extract comprises the following steps:
1) drying and crushing 1500g of Zingiber mioga plants, and sieving the crushed Zingiber mioga plants through a standard sieve of 20 meshes to obtain dry Zingiber mioga powder;
2) adding mioga ginger dry powder into an ethanol water solution with volume fraction of 50%, wherein the material-liquid ratio is 1: 6, extracting at 85 ℃ under reflux for 5 hours, filtering to obtain filtrate, distilling under reduced pressure to remove ethanol, and continuously drying at 90 ℃ to obtain a zingiber mioga crude extract;
3) taking a mioga ginger crude extract in a material-liquid ratio of 1: 20, adding water, stirring for 30 minutes, dissolving, and separating and purifying by using a PEG 6000/ammonium sulfate aqueous two-phase system: extraction temperature: 50 ℃, stirring time: 60 minutes; standing;
4) and (3) after extraction, collecting an inorganic salt lower phase, filtering and concentrating by using an ultrafiltration membrane, intercepting a polysaccharide solution with molecular weight of 3-20 kDa, and freeze-drying to obtain the Zingiber mioga ginger extract.
Fig. 1 is an infrared scanning spectrum of the zingiber mioga extract in example 1.
FIG. 1 is an infrared spectrum of the extract at 3400cm, as seen in FIG. 1-1Wide and strong absorption peaks appear at the left and right, which are caused by the stretching vibration of the hydroxyl groups of the polysaccharide; at 3000-2800 cm-1Two absorption peaks appearing on the left and right are represented by methyl C-H3Caused by stretching vibration; 1330cm-1The absorption peak is induced by C-H variable angle vibrationStarting; O-H and C-H are characteristic groups of polysaccharide substances; therefore, the extract of the present invention is a polysaccharide substance, as judged by the above characteristic peaks.
The spectrum is 1240cm-1The absorption peak is caused by S ═ O stretching vibration of sulfate groups, which indicates that the Zingiber mioga polysaccharide contains sulfate groups; at 1200-1000 cm-1The left and right absorption peaks are caused by the angle-changing oscillation of the ether bond C-O-C of the pyranose ring and the-OH group of the hydroxyl group. Analysis shows that the Zingiber mioga polysaccharide is an acidic heteropolysaccharide and contains a pyran ring.
Example 4
The bacteriostatic hand sanitizer for children comprises the following raw material components in percentage by weight:
phase A:
30% of water;
sodium laureth sulfate 8.0%;
2.0% of sodium methyl cocoyl taurate;
1.5% of glycerol;
phase B:
5.0% of the Zingiber mioga Rosc extract in example 1;
0.1% of vitamin E acetate;
EDTA-2Na 0.05％；
the balance of ionized water.
The preparation method comprises the following steps:
1) stirring the phase A, heating to 83 ℃, and keeping the temperature and stirring for 30 minutes;
2) adding the rest deionized water, adding the phase B, and continuously stirring for 30 minutes to obtain the final product.
Example 5
The bacteriostatic hand sanitizer for children comprises the following raw material components in percentage by weight:
phase A:
30% of water;
9.0 percent of sodium laureth sulfate;
1.0% of laureth-5-carboxylic acid;
2.0% of sodium lauroyl glutamate;
1.0% of glycerol;
phase B:
4.0% of the zingiber mioga rose extract in example 2;
0.1% of vitamin E phosphate;
EDTA-2Na 0.05％；
the balance of ionized water;
the preparation method comprises the following steps:
1) stirring the phase A, heating to 83 ℃, and keeping the temperature and stirring for 30 minutes;
2) adding the rest deionized water, adding the phase B, and continuously stirring for 30 minutes to obtain the final product.
Example 6
The bacteriostatic hand sanitizer for children comprises the following raw material components in percentage by weight:
phase A:
30% of water;
10.0 percent of sodium laureth sulfate;
1.0% of laureth-5-carboxylic acid;
1.0% of sodium lauroyl glutamate;
1.0% of glycerol;
phase B:
4.5% of the zingiber mioga rose extract in example 3;
0.13 percent of vitamin E acetate;
EDTA-2Na 0.05％；
the balance of ionized water;
the preparation method comprises the following steps:
1) stirring the phase A, heating to 83 ℃, and keeping the temperature and stirring for 30 minutes;
2) adding the rest deionized water, adding the phase B, and continuously stirring for 30 minutes to obtain the final product.
The following are contents of the effect test examples.
1. Antibacterial test verification
Selecting 10 children (half of male and female) with the age of 6-10, respectively measuring the total bacterial count (unit is CFU/hand) of two hands, then using the hand sanitizer of the embodiment 4 (or 5) of the invention to randomly wash one palm (experimental group) by using sterile water, and simultaneously using a blank control hand sanitizer (blank control group) without the Zingiber mioga extract of the invention to wash the other palm in the same way; after 3 hours the total number of bacteria in both palms was determined again.
The sampling method comprises the following steps: smearing the whole hand of the detected object with a cotton swab dipped with sterile normal saline twice, and placing the cotton swab into a test tube filled with 10mL of sterile normal saline for inspection and culture.
The detection method comprises the following steps: and fully shaking the sample solution, correspondingly diluting the sample solution by 10 times in an increasing way according to the sanitary condition, selecting 2-3 appropriate dilutions as plates for pouring or smearing culture, using common nutrient agar as a culture medium, enabling 3 dilutions to be parallel, injecting 100 mu L of sample solution into each plate, and counting the number of bacterial colonies after culturing for 24 hours at 37 ℃.
And (4) calculating a result: the total number of bacteria on each hand (cfu/hand) is the average number of colonies on the plate x dilution of the sample.
The results are shown in Table 1 below.
TABLE 1 results of bacteriostatic experiments
Note: increase in amount of measurement after hand washing-measurement after 3 hours
From the experimental results of table 1, it can be seen that: after 10 children in the experimental group used the bacteriostatic hand sanitizer of the present invention, the increase in the total bacteria count (mean of 75.1 cfu/hand) was significantly less than that in the blank control group (mean of 289.1 cfu/hand) after 3 hours.
The data show that after the bacteriostatic hand sanitizer disclosed by the invention is used, the growth and the propagation of bacteria on hands of children are inhibited, and the growth and the propagation of microorganisms are interfered by the Zingiber mioga ginger extract, so that the total number of bacteria is slowly increased and is obviously reduced compared with the total number of bacteria in a blank group, so that children are prevented from being infected from the mouth, the purpose of the hand sanitizer disclosed by the invention is achieved, and the technical effect is obvious.
2. Foam quantity, detergency, mildness test
The samples 4, 5 and 6 and the common liquid soap sold in the market (4 groups of samples) are handed to a 40-person evaluation group, each sample is randomly distributed to 10 persons for testing, the group members are required to sequentially grade the detergency, the foam quantity and the mildness of the samples according to a normal hand washing mode, and the grading principle adopts a 5-point system.
Wherein the evaluation scale was from 0-1 (poor), 1-2 (poor), 2-3 (satisfactory), 3-4 (good), 4-5 (very good), and the results were averaged for 10 scoring values. The results are shown in Table 2 below.
TABLE 2 foam level, detergency, mildness test results
| Item | Detergency | Amount of foam | Mildness property |
| Example 4 | 4.5 | 4.2 | 4.1 |
| Example 5 | 4.6 | 4.1 | 4.2 |
| Example 6 | 4.4 | 4.3 | 4.1 |
| Common hand sanitizer sold in market | 4.5 | 4.0 | 4.1 |
The results show that the embodiment of the invention has no significant difference from the common hand sanitizer sold in the market in three aspects of detergency, foam quantity and mildness, and the use effect of the hand sanitizer is not changed and still is good on the basis of the significant antibacterial performance of the composition.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in any way, so that any simple modification, equivalent change and modification made to the above embodiment according to the technical spirit of the present invention are within the scope of the technical solution of the present invention.
Claims (9)
1. The bacteriostatic hand sanitizer for children is characterized by comprising the following components in percentage by weight:
5.0-15.0% of surfactant, 1.0-3.0% of glycerol, 0.02-0.1% of EDTA-2Na, 0.05-0.2% of vitamin E, 2.0-7.0% of Zingiber mioga extract and the balance of deionized water.
2. The bacteriostatic hand sanitizer for children according to claim 1, which comprises: the paint consists of the following components in percentage by weight:
7.0-12.0% of surfactant, 1.5-2.0% of glycerol, 0.02-0.05% of EDTA-2Na, 0.1-0.15% of vitamin E, 3.5-5.5% of Zingiber mioga extract and the balance of deionized water.
3. The bacteriostatic hand sanitizer for children as claimed in claim 1, wherein: the surfactant is selected from one or more of sodium laureth sulfate, sodium cocoyl amphoacetate, sodium lauroyl sarcosinate, cocamidopropyl betaine, laureth-5 carboxylic acid, sodium methyl cocoyl taurate, sodium cocoyl isethionate and sodium lauroyl glutamate.
4. The bacteriostatic hand sanitizer for children as claimed in claim 1, wherein the Zingiber mioga ginger extract is extracted by the following process:
1) drying, crushing and sieving a mioga ginger plant to obtain mioga ginger dry powder;
2) adding mioga ginger dry powder into an ethanol water solution with volume fraction of 50%, wherein the material-liquid ratio is 1: 10-20 ℃, wherein the extraction temperature is 70-90 ℃, reflux extraction is carried out for 2-5 hours, after the extraction is finished, filtration is carried out to obtain filtrate, ethanol is removed by reduced pressure distillation, and drying is continued at 80-90 ℃ to obtain a zingiber mioga crude extract;
3) taking a mioga ginger crude extract in a material-liquid ratio of 1: 15-20, adding the mixture into water, stirring for 30 minutes, dissolving, separating and purifying, and standing;
4) and (3) after extraction, collecting an inorganic salt lower phase, filtering and concentrating by using an ultrafiltration membrane, and freeze-drying to obtain the Zingiber mioga ginger extract.
5. The bacteriostatic hand sanitizer for children as claimed in claim 4 and the preparation method thereof, characterized in that: in the step 1), sieving by a sieve with 10-30 meshes; in the step 3), a PEG 6000/ammonium sulfate aqueous two-phase system is used for separation and purification.
6. The bacteriostatic hand sanitizer for children as claimed in claim 5 and the preparation method thereof, characterized in that: in step 3), the extraction temperature: and (3) stirring at 40-50 ℃ for: 40-60 minutes; the molecular weight of the PEG is 400-6000, and the PEG accounts for 10-30% of the mass of the system; the ammonium sulfate accounts for 15-30% of the mass of the system.
7. The bacteriostatic hand sanitizer for children as claimed in claim 4, wherein: in the step 4), a polysaccharide solution with the molecular weight cutoff of 3-20 kDa is obtained, and the Zingiber mioga ginger extract is Zingiber mioga ginger polysaccharide.
8. The bacteriostatic hand sanitizer for children as claimed in claim 1, wherein: the vitamin E group includes vitamin E and its derivative compounds.
9. A preparation method of the bacteriostatic hand sanitizer for children as claimed in any one of claims 1 to 8, which is characterized by comprising the following steps: the method comprises the following steps:
1) heating deionized water accounting for 30% of the formula amount to 80-85 ℃, sequentially adding a surfactant and glycerol, and stirring for 30min under heat preservation;
2) and (3) supplementing the rest deionized water in the formula, cooling to 40-45 ℃, adding EDTA-2Na, vitamins E and the Zingiber mioga ginger extract dissolved by a small amount of deionized water, and continuously stirring for 30min to obtain the Zingiber mioga ginger extract.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010762270.1A CN111671711A (en) | 2020-07-31 | 2020-07-31 | Bacteriostatic hand sanitizer for children and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010762270.1A CN111671711A (en) | 2020-07-31 | 2020-07-31 | Bacteriostatic hand sanitizer for children and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111671711A true CN111671711A (en) | 2020-09-18 |
Family
ID=72458120
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010762270.1A Pending CN111671711A (en) | 2020-07-31 | 2020-07-31 | Bacteriostatic hand sanitizer for children and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111671711A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107157801A (en) * | 2017-06-13 | 2017-09-15 | 甘肃民族师范学院 | Containing natural Radix Salviae Miltiorrhizae polysaccharide compound antibacterial hand sanitizer and preparation method thereof |
| CN108840956A (en) * | 2018-05-04 | 2018-11-20 | 山西大学 | A kind of method of Bi-aqueous extraction purifying Dendrobium officinale polysaccharide |
| CN110638708A (en) * | 2019-11-01 | 2020-01-03 | 付世宁 | Wash-free hand sanitizer and preparation method thereof |
-
2020
- 2020-07-31 CN CN202010762270.1A patent/CN111671711A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107157801A (en) * | 2017-06-13 | 2017-09-15 | 甘肃民族师范学院 | Containing natural Radix Salviae Miltiorrhizae polysaccharide compound antibacterial hand sanitizer and preparation method thereof |
| CN108840956A (en) * | 2018-05-04 | 2018-11-20 | 山西大学 | A kind of method of Bi-aqueous extraction purifying Dendrobium officinale polysaccharide |
| CN110638708A (en) * | 2019-11-01 | 2020-01-03 | 付世宁 | Wash-free hand sanitizer and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 黄仁术等: "蘘荷多糖的提取工艺及其体外抑菌活性研究", 《吉林农业》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103767965A (en) | Forsythia suspensa leaf hand sanitizer and preparation method thereof | |
| CN103766409A (en) | Walnut green seedcase extract product and bacteriostatic use thereof | |
| CN103585074A (en) | Rabdosia rubescens aqueous extract, use of rabdosia rubescens aqueous extract, rabdosia rubescens extract, skin care product and preparation methods of rabdosia rubescens aqueous extract and skin care product | |
| CN112754956A (en) | Formula and preparation method of cactus polysaccharide anti-inflammatory moisturizing mask | |
| CN112043647A (en) | Formula and preparation process of smoothing and anti-dandruff tea bran shampoo | |
| CN109010178B (en) | Shower gel and production process thereof | |
| CN101942362A (en) | Chinese medicinal herb-fruit mixed incense base, and preparation method and application thereof | |
| CN109793696B (en) | Anti-dandruff plant composition and preparation method and application thereof | |
| CN105902420A (en) | Exfoliating facial cleanser | |
| CN104585306A (en) | Method for preparing rhizoma smilacis glabrae extract, rhizoma smilacis glabrae extract and application of extract | |
| CN106137863A (en) | A kind of infant multiple-effect skin lotion | |
| US9539296B2 (en) | Eye-refreshing agent to eliminate and alleviate eye fatigue and discomfort | |
| CN112741795A (en) | Skin-care shower gel containing natural plant extract components and preparation method thereof | |
| CN111671711A (en) | Bacteriostatic hand sanitizer for children and preparation method thereof | |
| CN114306526B (en) | Compound broadleaf holly leaf traditional Chinese medicine extract and application thereof in preparing shower gel or hand sanitizer | |
| CN110585081A (en) | Antibacterial and itching-relieving shampoo containing folium artemisiae argyi essential oil and preparation method thereof | |
| CN110507572A (en) | A kind of bacteriostasis, and deodorization toothpaste and preparation method thereof | |
| CN112043650B (en) | Acne-removing repairing cosmetic preparation and preparation method thereof | |
| CN109939030A (en) | A kind of hand cleanser and preparation method thereof of natural bacteriostatic anti-inflammatory | |
| CN110917077B (en) | Natural plant bath foam | |
| CN106562437A (en) | Health product prepared from bamboo leaf extract and preparation method thereof | |
| CN113750209A (en) | Herbaceous plant antibacterial liquid | |
| CN111297768B (en) | Antioxidant active composition, antioxidant mask and preparation and application of antioxidant active composition and antioxidant mask | |
| AU2021103393A4 (en) | A Formula of a Traditional Chinese Medicine Bacteriostatic Disinfectant and Preparation Method Thereof | |
| CN101167881B (en) | Lung-clearing composition containing tomato plant stem extraction and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |