CN111642658A

CN111642658A - Anti-wrinkle moisturizing composition

Info

Publication number: CN111642658A
Application number: CN202010110982.5A
Authority: CN
Inventors: 苟晓会; 吴丹丹; 李珍珍; 曹美霞; 靳莉
Original assignee: Dongguan Natural Salutem Health Technology Co ltd
Current assignee: Dongguan Natural Salutem Health Technology Co ltd
Priority date: 2020-02-24
Filing date: 2020-02-24
Publication date: 2020-09-11

Abstract

The invention provides an anti-wrinkle moisturizing composition which comprises the following components in parts by mass: 3-20 parts of collagen tripeptide, 0.005-0.1 part of proteoglycan, 0.01-0.1 part of rice ceramide and 0.1-0.4 part of sodium carboxymethylcellulose. The anti-wrinkle moisturizing composition prepared by the invention is not added with components such as preservative, essence and the like, and the prepared beverage is safe and effective through various verifications.

Description

Anti-wrinkle moisturizing composition

Technical Field

The invention belongs to the technical field of food, and particularly relates to an anti-wrinkle moisturizing composition.

Background

Collagen is a functional protein with the largest content and the widest distribution in mammals, is mainly present in connective tissues of animals, and plays a role in supporting organs and protecting organisms. Collagen accounts for more than 70% of the total amount of human skin protein, and with the increase of age, the synthesis capacity of the collagen in the skin is reduced, the skin loses elasticity, and skin relaxation and wrinkles are formed. Two methods are mainly used for treating skin relaxation and wrinkles caused by collagen loss, namely, nutrient components are introduced through the skin by medical and beauty means; and secondly, the collagen supplement is orally taken to play a role in supplementing collagen.

The existing collagen oral products on the market mainly comprise tablets, capsules, solid beverages and liquid beverages. Patent CN201811156440.0 discloses a collagen peptide beverage, the main component of which is collagen peptide with molecular weight of 800Da-1000Da, and the absorption rate is relatively low; and the addition of the edible essence brings certain safety risk. Patent CN201910208302.0 discloses a beverage for maintaining beauty and keeping young, which is mainly added with components such as fish collagen peptide, elastin and the like to play a role of collagen supplement, the effect is relatively single, and in the technical scheme, preservatives such as potassium sorbate and the like are added to prolong the shelf life, so that the beverage is not suitable for long-term eating.

Therefore, there is a need to provide an anti-wrinkle moisturizing composition that is safe, effective, and well absorbed.

Disclosure of Invention

The invention aims to provide an anti-wrinkle moisturizing composition which is safe, effective and well absorbed.

In order to achieve the aim, the invention provides an anti-wrinkle moisturizing composition which comprises collagen tripeptide, proteoglycan, rice ceramide and sodium carboxymethylcellulose.

Further, the collagen tripeptide, the proteoglycan and the rice ceramide are respectively 3-20 parts, 0.005-0.1 part, 0.01-0.1 part and 0.1-0.4 part by weight respectively.

Specifically, the collagen tripeptide is 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts and 20 parts by weight of the composition; the proteoglycan is 0.005 part, 0.025 part, 0.055 part, 0.075 part, 0.01 part, 0.02 part, 0.03 part, 0.04 part, 0.05 part, 0.06 part, 0.07 part, 0.08 part, 0.09 part and 0.1 part by weight of the composition; the rice ceramide is 0.01 part, 0.02 part, 0.03 part, 0.04 part, 0.05 part, 0.06 part, 0.07 part, 0.08 part, 0.09 part and 0.1 part by weight of the composition; the mass parts of the sodium carboxymethylcellulose in the composition are 0.1 part, 0.15 part, 0.2 part, 0.25 part, 0.3 part, 0.35 part and 0.4 part.

Preferably, the collagen tripeptide has a molecular weight of 200Da to 500 Da.

Preferably, the collagen tripeptide has a molecular weight of 400 Da.

Further, the composition also comprises the following components: sour cherry powder, German broom cypress, and strawberry seed extract.

Further, the weight portion of the sour cherry powder in the composition is 0.01-0.1, the weight portion of the German broom cypress in the composition is 0.5-1, and the weight portion of the strawberry seed extract in the composition is 0.01-0.1.

Specifically, the sour cherry powder is 0.01 part, 0.02 part, 0.03 part, 0.04 part, 0.05 part, 0.06 part, 0.07 part, 0.08 part, 0.09 part and 0.1 part by mass in the composition; the weight parts of the German linear sparrow flower in the composition are 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part and 1 part; the mass parts of the strawberry seed extract in the composition are 0.01 part, 0.02 part, 0.03 part, 0.04 part, 0.05 part, 0.06 part, 0.07 part, 0.08 part, 0.09 part and 0.1 part.

Preferably, the content of the argonidin in the strawberry seed extract is more than 2%.

Further, the composition also comprises the following components: sweet cherry concentrated juice and juicy peach concentrated juice.

Furthermore, the mass parts of the sweet cherry concentrated juice in the composition are 2-6, and the mass parts of the juicy peach concentrated juice in the composition are 2-6.

Specifically, the mass parts of the sweet cherry concentrated juice in the composition are 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts and 6 parts; the mass parts of the juicy peach concentrated juice in the composition are 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts and 6 parts.

The invention also provides an application of any one of the compositions in preparing a product with the functions of resisting wrinkles and replenishing water, wherein the product comprises the concentrated juice for resisting wrinkles and replenishing water, the oral liquid for resisting wrinkles and replenishing water, the concentrated capsule for resisting wrinkles and replenishing water and the jelly for resisting wrinkles and replenishing water.

The invention also provides a preparation method of the anti-wrinkle moisturizing composition, which comprises the following steps:

(1) adding collagen tripeptide, proteoglycan, rice ceramide, sour cherry powder and German broom cypress into sterile water, and uniformly mixing to obtain a mixed solution A;

(2) heating sterile water to 70 ℃, adding sodium carboxymethylcellulose, and rapidly stirring for dissolving to obtain sodium carboxymethylcellulose solution;

(3) adding the mixed solution A into a sodium carboxymethylcellulose solution, uniformly mixing to obtain a mixed solution B, sequentially adding the sweet cherry concentrated juice and the juicy peach concentrated juice into the mixed solution B, and uniformly stirring to obtain a mixed solution C;

(4) filtering the mixed solution C to remove impurities, and homogenizing by using a homogenizer;

(5) and sterilizing the homogenized mixed solution C for 8s at the ultrahigh temperature of 140 ℃ to obtain the anti-wrinkle moisturizing composition.

And (5) carrying out the steps (1) to (5) in a clean area.

Compared with the prior art, the invention has the beneficial effects that:

the collagen tripeptide has small molecular weight, can be quickly absorbed by a human body, is combined with skin epithelial cells through the horny layer, participates in and improves the metabolism of the skin cells, enhances the activity of collagen in the skin and increases the skin elasticity.

The proteoglycan is high-purity and high-content proteoglycan extracted from salmon nasal cartilage, and has excellent water locking capacity because water molecules can be firmly clamped in the proteoglycan due to a multi-layer glycosaminoglycan structure; secondly, proteoglycan has the function of improving the renewal capacity of epidermal cells per se, can generate a plurality of effective components and promotes the health of skin.

Rice ceramide is ceramide extracted from rice, has strong ability of associating water molecules, maintains skin moisture by forming a network structure in a horny layer, is absorbed by small intestine through oral administration, is transferred to blood, is transported to the whole body, can promote self biosynthesis of ceramide in the body, and is a good recovery and regeneration of skin cells of the whole body.

The sour cherry powder is rich in procyanidine, can inhibit degradation of tryptophan in vivo, further has sleep-aiding effect, and does not produce dependence.

The German larkspur broom, also called south Africa tea or south Africa doctor tea, is a herbaceous needle-shaped shrub growing in areas such as Cedarberg, Sikapton, south Africa, contains rich antioxidant flavonoids, and has remarkable curative effects on scavenging free radicals of human bodies, regulating functions of the human bodies, and preventing and controlling various diseases.

The strawberry seed extract is polyphenol compound extracted from strawberry seed, is rich in argentine and kaempferol 3-O-glucoside, and has effects of protecting liver, resisting obesity, and resisting inflammation.

Sodium carboxymethylcellulose is easily dissolved in water to form transparent colloidal emulsion, and can be used as emulsion stabilizer to stabilize mixed solution.

The sweet cherry is rich in anthocyanin and vitamin C, wherein the vitamin C can promote the generation of collagen, and the anthocyanin can help the collagen fibers to form a cross-linked structure so as to recover the condition of excessive cross-linking of the collagen fibers caused by injury and free radicals. The sweet cherry concentrated juice selected by the invention is 6 times of the commercially available concentrated juice, and has the functions of relieving muscle injury, protecting eyesight, relieving edema, nursing skin and the like.

The honey peach contains various proteins, trace elements, carotene, vitamin B1, vitamin C and other ingredients, and helps to supplement nutritional ingredients required by a human body; the juicy peach concentrated juice selected by the invention is 6 times of the commercially available concentrated juice, so that the nutritional ingredients required by a human body can be supplemented, and the flavor of the composition can be improved.

The anti-wrinkle moisturizing composition prepared by the invention can supplement collagen, restore skin elasticity and fade fine lines, has the effects of resisting oxidation and moisturizing, has natural fruit flavor and good taste; the anti-wrinkle moisturizing composition prepared by the invention is not added with components such as preservative, essence and the like, and the prepared composition is safe and effective through various verifications.

Drawings

Fig. 1 is a graph showing the moisture change of the skin of a volunteer after using the anti-wrinkle moisturizing compositions prepared in examples 1 to 6;

fig. 2 is a graph showing the change of oil content in skin of volunteers after using the anti-wrinkle moisturizing compositions prepared in examples 1 to 6;

fig. 3 is a graph showing the skin elasticity change of volunteers after using the anti-wrinkle moisturizing compositions prepared in examples 1 to 6;

fig. 4a shows facial wrinkles of volunteers before Visia detected using the anti-wrinkle moisturizing composition prepared in example 2;

fig. 4b shows facial wrinkles of volunteers after 3 months using the anti-wrinkle moisturizing composition prepared in example 2 detected by Visia;

fig. 5a shows facial wrinkles of volunteers before Visia detected using the anti-wrinkle moisturizing composition prepared in example 4;

fig. 5b shows facial wrinkles of volunteers after 3 months using the anti-wrinkle moisturizing composition prepared in example 4 detected by Visia;

fig. 6a shows facial wrinkles of volunteers before Visia detected using the anti-wrinkle moisturizing composition prepared in example 6;

fig. 6b shows facial wrinkles of volunteers after 3 months using the anti-wrinkle moisturizing composition prepared in example 6 detected by Visia;

fig. 7a shows facial speckle condition of volunteers before Visia detection using the anti-wrinkle moisturizing composition prepared in example 2;

fig. 7b shows facial speckle condition of volunteers after 3 months using the anti-wrinkle moisturizing composition prepared in example 2 detected by Visia;

fig. 8a shows facial speckle of volunteers before Visia detects the anti-wrinkle moisturizing composition prepared in example 4;

fig. 8b is a facial speckle condition of volunteers after 3 months using the anti-wrinkle moisturizing composition prepared in example 4 detected by Visia;

fig. 9a shows facial speckle of volunteers before Visia tests using the anti-wrinkle moisturizing composition prepared in example 6;

fig. 9b shows facial speckle of volunteers after 3 months using the anti-wrinkle moisturizing composition prepared in example 6 tested by Visia.

Detailed Description

The technical solution of the present invention will be further described by the following specific examples.

Example 1

The embodiment provides an anti-wrinkle moisturizing composition which comprises the following components in parts by mass: 8 parts of collagen tripeptide, 0.005 part of proteoglycan, 0.03 part of rice ceramide and 0.2 part of sodium carboxymethylcellulose.

Example 2

The embodiment provides an anti-wrinkle moisturizing composition which comprises the following components in parts by mass: 10 parts of collagen tripeptide, 0.05 part of proteoglycan, 0.05 part of rice ceramide, 0.3 part of sodium carboxymethylcellulose, 0.02 part of sour cherry powder, 0.1 part of German linea broom, 0.05 part of strawberry seed extract, 2 parts of sweet cherry concentrated juice and 2 parts of juicy peach concentrated juice.

Example 3

The embodiment provides an anti-wrinkle moisturizing composition which comprises the following components in parts by mass: 5 parts of collagen tripeptide, 0.03 part of proteoglycan, 0.08 part of rice ceramide, 0.3 part of sodium carboxymethylcellulose, 0.08 part of sour cherry powder, 0.6 part of German linea broom, 0.03 part of strawberry seed extract, 5 parts of sweet cherry concentrated juice and 4 parts of juicy peach concentrated juice.

Example 4

The embodiment provides an anti-wrinkle moisturizing composition which comprises the following components in parts by mass: 10 parts of collagen tripeptide, 0.06 part of proteoglycan, 0.04 part of rice ceramide, 0.4 part of sodium carboxymethylcellulose, 0.03 part of sour cherry powder, 1 part of German broom cypress, 0.1 part of strawberry seed extract, 4 parts of sweet cherry concentrated juice and 4 parts of juicy peach concentrated juice.

Example 5

The embodiment provides an anti-wrinkle moisturizing composition which comprises the following components in parts by mass: 6 parts of collagen tripeptide, 0.06 part of proteoglycan, 0.06 part of rice ceramide, 0.4 part of sodium carboxymethylcellulose, 0.06 part of sour cherry powder, 0.5 part of German broom cypress, 0.05 part of strawberry seed extract, 5 parts of sweet cherry concentrated juice and 3 parts of juicy peach concentrated juice.

Example 6

The embodiment provides an anti-wrinkle moisturizing composition which comprises the following components in parts by mass: 20 parts of collagen tripeptide, 0.1 part of proteoglycan, 0.1 part of rice ceramide, 0.2 part of sodium carboxymethylcellulose, 0.1 part of sour cherry powder, 1 part of German broom cypress, 1 part of strawberry seed extract, 6 parts of sweet cherry concentrated juice and 4 parts of juicy peach concentrated juice.

The method for preparing the anti-wrinkle moisturizing composition according to embodiments 1 to 6 comprises the following steps:

And (5) carrying out the steps (1) to (5) in a clean area.

Effect verification

The anti-wrinkle and moisturizing compositions prepared in examples 1 to 6 were subjected to acute oral toxicity verification and efficacy verification, and the verification results were as follows.

(1) Acute oral toxicity verification

The test samples were the wrinkle resistant moisturizing compositions prepared in examples 1 to 6. The test method refers to the operation method of a one-time limit method in an acute toxicity test of health food inspection and evaluation technical specification (2003 edition), and the sample to be tested acts on the test mouse in a stomach-perfusion mode in batches with a normal dose of 4.5mL/kg and a high dose of 20 mL/kg.

The test object was Kunming white mouse.

The specific test operation is as follows:

screening 60 female and male mice respectively, dividing the mice into 12 groups, and 5 female and male mice in each group, wherein 6 groups are tested in a normal dosage, and numbering is carried out according to corresponding test samples; high dose test 6 groups, also numbered according to the corresponding test samples.

The test mice were fasted for 8 hours before gavage, observed for 7 days after gavage, and the general status, toxicity performance and death number of the mice were recorded. The test results were averaged by panel to give tables 1 and 2.

TABLE 1 test mouse mortality and abnormal Activity rates

TABLE 2 weight change before and after gastric lavage of test mice

From the results of tables 1 and 2, it can be seen that the mice in the normal group and the high dose group had normal activities, a mortality rate of 0, and a normal weight gain after the gavage. It is demonstrated that the anti-wrinkle moisturizing compositions prepared in examples 1 to 6 of the present invention are safe and non-toxic.

(2) Efficacy verification

60 volunteers between 28-45 years of age were selected and divided into 6 groups.

Firstly, detecting the moisture, grease and elasticity of the face of a volunteer by using a Real Bube RBX-916 detector to obtain initial data; then, each group of volunteers used the anti-wrinkle moisturizing composition prepared in examples 1 to 6, 50mL per day, and continuously took for 8 weeks; the water, grease and elasticity of the facial skin of the volunteers are detected by a Real Bubee RBX-916 detector at a fixed time every week, and data are recorded. The average values were obtained to compare the moisture, oil and skin elasticity data of the skin of the volunteers before and after using the anti-wrinkle moisturizing compositions prepared in examples 1 to 6.

The results are shown in fig. 1, fig. 2 and fig. 3, which are obtained by recording and comparing the facial skin moisture, oil and elasticity data of volunteers before, after 1 week, 2 weeks, 3 weeks, 4 weeks, 5 weeks, 6 weeks, 7 weeks and 8 weeks after the administration of the anti-wrinkle moisturizing composition, and averaging the data of each group. The results showed that the moisture content of facial skin of volunteers was significantly increased (see fig. 1), the lipid content was significantly decreased (see fig. 2), and the elasticity of facial skin was increased (see fig. 3) after the collagen products prepared in examples 1 to 6 were administered.

Secondly, detecting the facial wrinkles and spots of the volunteers by using a Visia tester, and taking a picture for recording; then, each group of volunteers used the anti-wrinkle moisturizing composition prepared in examples 1 to 6, 50mL per day, and continuously took for 3 months; after 3 months, the facial wrinkles and spots of the volunteers are detected by a Visia tester and photographed and recorded. Note: the volunteers do not take the anti-wrinkle moisturizing composition prepared by the invention at the same time when taking the anti-wrinkle moisturizing composition.

By comparing skin conditions of the volunteers before and after using the anti-wrinkle moisturizing compositions prepared in examples 1 to 6, it can be seen that wrinkles and spots on the facial skin of the volunteers are remarkably reduced. As shown in fig. 4 a-9 b, after the volunteers used the collagen drinks prepared in examples 1, 2 and 4 of the present invention for 3 months, the facial wrinkles and spots were significantly improved, which proves that the technical solution of the present invention has the ability of collagen supplementation and oxidation resistance.

The above examples are only for further illustration of the technical solution of the present invention and should not be construed as limiting the scope of the present invention. It will be appreciated by those skilled in the art that any modifications and alterations to the embodiments of the invention which do not require inventive faculty will fall within the scope of the invention.

Claims

1. The anti-wrinkle moisturizing composition is characterized by comprising the following components: collagen tripeptide, proteoglycan, rice ceramide and sodium carboxymethylcellulose.

2. The composition as claimed in claim 1, wherein the collagen tripeptide is present in the composition in an amount of 3 to 20 parts by weight, the proteoglycan is present in the composition in an amount of 0.005 to 0.1 part by weight, the rice ceramide is present in the composition in an amount of 0.01 to 0.1 part by weight, and the sodium carboxymethylcellulose is present in the composition in an amount of: 0.1 to 0.4 portion.

3. The composition of claim 1, wherein the collagen tripeptide has a molecular weight of 200Da to 500 Da.

4. A composition according to claim 3, wherein the collagen tripeptide has a molecular weight of 400 Da.

5. The composition of claim 1, wherein the composition further comprises the following components: sour cherry powder, German broom cypress, and strawberry seed extract.

6. The composition of claim 5, wherein the sour cherry powder is 0.01-0.1 part by weight of the composition, the German broom cypress is 0.5-1 part by weight of the composition, and the strawberry seed extract is 0.01-0.1 part by weight of the composition.

7. The composition of claim 5, wherein the fraxin content in the strawberry seed extract is greater than 2%.

8. The composition of claim 6, wherein the composition further comprises the following components: sweet cherry concentrated juice and juicy peach concentrated juice.

9. The composition of claim 8, wherein the sweet cherry juice concentrate is present in the composition in an amount of 2 to 6 parts by weight, and the juicy peach juice concentrate is present in the composition in an amount of 2 to 6 parts by weight.

10. Use of the composition according to any one of claims 1 to 9 for the preparation of a product having anti-wrinkle moisturizing function, the product comprising an anti-wrinkle moisturizing concentrated juice, an anti-wrinkle moisturizing oral liquid, an anti-wrinkle moisturizing concentrated capsule, an anti-wrinkle moisturizing jelly.

11. A process for the preparation of a composition according to any one of claims 1 to 9, characterized in that it comprises the following steps: