CN111631991A - 一种私密护理洗液 - Google Patents
一种私密护理洗液 Download PDFInfo
- Publication number
- CN111631991A CN111631991A CN201910149449.7A CN201910149449A CN111631991A CN 111631991 A CN111631991 A CN 111631991A CN 201910149449 A CN201910149449 A CN 201910149449A CN 111631991 A CN111631991 A CN 111631991A
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- Prior art keywords
- sodium
- salt
- amino acid
- content
- sulfonate
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Classifications
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Abstract
本发明提供了一种具有促进粘膜损伤及炎症修复、调节体液分泌、除味护肤等功能的护理洗液，该洗液含有1‑10重量份的茶皂素或者氨基酸表面活性剂亦或者两者以任何比例组成的混合物、0.05‑2重量份的愈创木精油、0.05‑5重量份的乳香及其提取物、0.01‑1重量份的薁磺酸钠、0‑0.2重量份的薄荷脑、87‑98重量份的基液(由少量酒精和纯净水组成)体系。本发明制备的新型护理洗液能有效促进细胞组织愈合再生，对损伤的粘膜溃疡有很好的改善效果，能消肿止疼，解毒生肌，还可以调整人体体液分泌，促进人体生殖系统功能恢复。且采用温和亲肤的茶皂素和氨基酸类表面活性剂，具有抗过敏作用。尤其适用于性生活活跃人群天天养护清洁。效果优异。
Description
【技术领域】
本发明涉及一种私密护理洗液，具体的说，本发明涉及一种具有促进粘膜损伤及炎症修复、调节体液分泌、除味护肤等功能的护理洗液，属于生活日用品领域。
【背景技术】
现在人们的生活压力普遍大增，加之生活作息没有规律，环境污染问题也愈发严重，人们的抵抗力普遍下降，身体往往处于亚健康状态。常此以往，女性会出现阴部瘙痒、异味、分泌物增多、阴道炎等疾病，男性也常常被生殖系统问题困扰。故而越来越多的男性女性选择专业的护理液来清洁身体，以维护自身的外阴卫生。
女性生殖器是一个开放性腔道，其自身的生理解剖特点使得女性极易受细菌、霉菌的感染而致病，这个部位温暖潮湿非常适合病原菌的生长繁殖，阴道分泌物还富含蛋白质，也为病原生物繁殖提供了有利条件，当女性免疫功能降低的时候，或者因为生活卫生条件差以及存在不洁的性行为的时候，就会导致病原生物感染而致病。因此女性外阴部位用特定的外用护理洗液进行清洁护理就十分的必要。而当阴部清洁不当，也会造成炎症，如长期使用强杀菌性洗液清洗，在杀灭有害病原性微生物的同时也杀灭了阴道内益生菌，使阴道不能保持自我微酸性的环境而更容易被感染，或者阴部受到机械性或碱性刺激后，肌肤表皮变薄引起瘙痒，瘙痒后更容易导致肌肤炎症等问题。使人产生不舒服感。
据调查，25％的女性每天使用洗液，58％的人一周至少使用1次，这些数据表明，洗液已经成为女性保健的常用品。
近年来，随着社会的发展，人们的性观念越来越开放，婚外性行为、同性性行为也越来越多，在男性中的比例尤其高，这些行为极大的增加了人们生殖器感染的几率，为了避免染上性疾病，人们多自用一些外用消毒、消炎的清洁剂清洗，甚至有一些人为了消毒彻底，在生殖器等部位皮肤直接涂抹清洁剂液体，这样局部皮肤受到强烈的化学刺激出现红肿、渗出而出现急性炎症。这些炎症包括感染性的和非感染性的。感染性的常由于不洁性行为，感染了病原性细菌引起，非感染性的会由于局部创伤，糜烂或脏污刺激局部粘膜而发生炎症。男性生殖系统炎症危害巨大，不仅表现为危害生殖系统健康，有的甚至会引起泌尿系统疾病，或者导致性功能障碍。严重者会造成不育症。这些生殖系统问题，由于部位隐秘，很多人不愿去医院就诊，因此迫切需要一种见效快，效果好，清洁性好的护理型清洗剂，能让患者轻松方便的自行使用解决生殖系统的清洁、卫生、促进炎症愈合。
目前常见的洗液分为三类：清洁护理保养型、抗抑菌型以及治疗型洗液，治疗型洗液属于药类，在女性确诊感染各种阴道炎时使用，一般在医院和药房使用销售，这种洗液只在发病期间起治疗作用，短期使用；抗抑菌型洗液主要用于私处抗抑菌，但据报道，长期使用抗抑菌洗液会杀灭阴道内维持微酸性环境的益生菌，破坏阴道自洁系统，反而更容易引发妇科炎症问题。清洁护理保养型主要用于私处正常分泌排泄时对阴部的清洁，这类产品有些单一注重强清洁力，没有注重护理与保养，不仅起不到正常的护理预防效果，反而会因为刺激性强导致阴部皮肤受损，对于轻微炎症类皮肤会加重炎症病情。因此人们迫切需要一款安全性好，温和的护理型的洗液。以解决人们私密处的各种烦恼问题。本发明专利就是这样的一款护理液。
本发明专利的新型洗液采用天然的茶皂素或者亲肤温和的氨基酸类表面活性剂，添加具有抗炎、抗过敏作用和促进细胞组织愈合再生功能的薁磺酸钠；还添加具有调节体液分泌，舒解经痛，改善炎症的愈创木精油；以及具有抗炎、抗菌、抗溃疡功能的传统中药乳香，〖医学衷中参西录〗谓乳香：“外用为粉以敷疮疡，能解毒，消肿、生肌、止疼”，〖本草经疏〗亦云：“今人用以治内伤诸痛，及肿毒内服外敷之药”。这种新型护理型洗液安全温和不刺激皮肤，还可以抗菌消炎、解毒生肌、对粘膜损伤溃疡有良好的改善作用，还可以调整人体体液分泌，促进人体生殖系统功能恢复。
【发明内容】
本发明的目的是提供一种安全的，有协助私密处炎症和损伤修复的、能有效调整人体体液分泌。保障私处健康，为大众愉悦的性生活保驾护航的新型护理洗液。
这种新型护理型洗液安全温和不刺激皮肤，还可以抗炎、解毒生肌、对粘膜损伤溃疡有良好的改善作用，还可以调整人体体液分泌。呵护私处健康。
本发明的另一个目的是提供一种护理液的制备方法。结合护理液技术方案，下面详细对本发明及其制备方法进行阐述。
技术方案：
本发明提供一种安全的、抗炎、防止私密处炎症促进黏膜再生、能有效调整人体体液分泌，呵护私处健康，男女均适用的护理液。是通过以下技术方案实现的，护理液配方如下(以重量份计)：
上述配方中的基础液体系为纯净水和无水乙醇构成，愈创木精油、薄荷脑为不溶水的物质，故需要先将其溶解于无水乙醇中增溶，然后再溶解于纯净水中，因此基础液体系由乙醇和纯净水构成，其中无水乙醇用量为精油和薄荷脑用量 (重量份)的2-2.5倍，其余部分由纯净水补足。
本发明的另一个目的是提供一种护理液的制作方法，首先将表面活性剂加入到10-20份的纯净水中，搅拌至其全部溶解形成液体组份①；将愈创木精油、薄荷脑加入是其重量份2-2.5倍的无水乙醇中，搅拌至其完全溶解形成液体组分②；将乳香提取物、薁磺酸钠加入到10-20份的纯净水中，搅拌溶解形成液体组分③；将液体组分②、③依次加入液体组分①中，搅拌均匀后，加入剩余量的纯净水，搅拌均匀。就制得护理液。
本发明所述的表面活性剂，可以是天然表面活性剂茶皂素、也可以是氨基酸类表面活性剂，这类表面活性剂呈弱酸性，接近人体表皮皮脂膜的PH值，性质温和，清洁时对肌肤刺激小，适合任何肌肤。也有利于维持女性私处弱酸性环境，有利于益生菌的生长繁殖，从而给女性阴道提供最好的保护。
本发明所述的愈创木精油，英文名Guaiacwood，蒸馏自愈创木的木心，精油气味深沉而强劲，隐隐带着香草气息的泥土味。一般而言可调节体液分泌，有助于性方面的障碍，例如停经期因阴道干涩而导致的性交疼痛。愈创木神秘的特质与大地之母的气息，都说明了它享有催情盛誉的缘故，它也能舒解经痛。愈创木精油可以给予松弛的生殖泌尿系统正面的影响，使其作用重上轨道，愈创木在此的功能就像利尿剂与轻泻剂。
本发明所述的乳香提取物，具有活血定痛、消肿生肌、痈肿疮疡的功效。〖医学衷中参西录〗谓：“外用为粉以敷疮疡，能解毒，消肿、生肌、止疼”。乳香及其提取物的药理作用主要有抗炎、抗菌、抗肿瘤、抗溃疡、改善记忆、抗氧化等药理活性。乳香为橄榄科植物乳香树及同属植物树皮渗出的树脂，乳香提取物为棕黄色微细粉末。分子式C32H48O5，CAS号为67416-61-9。
本发明所述的薁磺酸钠，化学名称：1，4-二甲基-7-异丙基薁-3-磺酸钠，别名：愈创木薁磺酸钠，水溶性薁，呱仑酸钠，甘油磷酸二钠盐五水合物，AZ， Azulene。英文名：Sodium Guaiazulene Sulfonate或Sodium Azulene Sulfonate简称：SGS。CAS：6223-35-4，纯度为98％以上，生化级或医药级产品。具有较强的生物活性，有抗菌消炎、抗过敏作用和促进细胞组织再生功能。
本发明所述的薄荷脑也叫薄荷醇，系由薄荷的叶和茎中所提取，白色晶体，分子式C10H20O，为薄荷和欧薄荷精油中的主要成分。在医药上用作刺激药，作用于皮肤或粘膜，有清凉止痒作用。
下面进一步更详细的描述本发明的技术方案：
进一步的所述的表面活性剂，优选的可以是天然表面活性剂茶皂素、也可以是氨基酸类表面活性剂。还可以是两者以任何比例混合的混合物。
本发明专利所述的茶皂素，又名茶皂甙，是从山茶科植物的种子中提取的一种糖苷化合物，它属皂素类，因其分子中含有亲水性的糖体部分和疏水性的皂甙配基部分而成为性能优良的天然非离子型表面活性剂，其水溶液呈弱酸性，PH 值5.0-6.5，这些特点赋予了茶皂素温和适中的清洗能力。而其独特的结构同时还赋予茶皂素特别的生物活性，抑菌、杀虫、抗氧化、抗渗消炎等性能，据报道茶皂素对大肠杆菌、金黄色葡萄球菌、枯草芽孢杆菌、酵母菌有较明显的抑制作用，对白色念珠菌有一定的抑制作用。茶皂素还具有显著的清除羟自由基和超氧阴离子自由基的能力，说明它具有比较强的抗氧化性。
更具体的本发明所述的茶皂素优选为活性物含量≥75％含量，颜色浅黄色， 1％水溶液透明，无沉淀，无上浮物，水分含量小于5％，细度100目以上。本专利所用的茶皂素为市售产品，优选为江西乔盛茶皂素科技有限公司以及湖南汉清生物技术有限公司的产品。
本发明专利所述的表面活性剂的另一优选方案还可以是氨基酸类表面活性剂，氨基酸类表面活性剂具有弱酸性，PH值5.0-6.5，接近人体表皮皮脂膜的PH 值，因此氨基酸类产品性质温和，清洁时对肌肤没有刺激，适合任何肌肤，再加上氨基酸本身又是构成蛋白质的基本物，所以更加温和亲肤，低刺激，小孩和敏感肌都可以用。同时氨基酸还能代替被洗掉的天然保湿因子，起到高效补水保湿的作用，养护皮脂膜。使用后无残留，没有后顾之忧，可长期使用。和传统皂基类、硫酸酯类日化产品相比，天然茶皂素和氨基酸类护理液，不仅有足够的清洁力，性质还非常的温和，不会给肌肤造成伤害(缺水，破坏肌肤屏障)，反而能够呵护肌肤(补水保湿)。
本专利所述的氨基酸类表面活性剂是指包括椰子油(或者月桂油或者棕榈油)的氨基酸(比如谷氨酸、甘氨酸等)盐(钠盐、钾盐、三乙醇胺盐)类的一系列表面活性剂。氨基酸表面活性剂基本构成＝油脂+酰+XX氨酸+XX盐。油脂有：月桂、肉豆蔻、椰油、棕榈、硬脂等；氨酸有：谷氨酸、甘氨酸、丙氨酸、精氨酸、肌氨酸等；盐有：钠盐、钾盐、三乙醇胺盐等。如：肉豆蔻酰谷氨酸钠、椰油酰甘氨酸钾、椰油酰精氨酸乙酯盐、月桂酰肌氨酸钠等等。
进一步的本专利所述的愈创木精油：其化学结构为醇类--Bulnesol、愈创木醇，具有消炎、抗风湿、催情、收敛作用，可以使人放松，安抚神经紧张。可调节体液分泌，有助于性方面的障碍，也能舒解经痛。给予松弛的生殖泌尿系统正面的影响，使其作用重上轨道。
优选的，本发明优选的使用95％含量的乳香提取物粉体，粒径为80目。有效成分含量越高，杂质较少，由其制作的产品不仅消炎止痛、治疗溃疡、消肿、生肌、杀菌能力强，活血效果好；而且由于杂质含量少，产品透明度也十分优异。由于乳香提取物可以溶于水，其粒径大小并无影响。本专利所使用的乳香提取物为市售产品，如陕西嘉禾生物科技有限公司的高纯度乳香提取物。
进一步的本发明所述的薁磺酸钠，优选的采用纯度为98％以上的产品，纯度越高，有效成分含量越高。本专利所述的薁磺酸钠可以是化妆品级、也可以是医药级的，其中优选为化妆品级的。更进一步的产品中重金属含量：≤20ppm；砷盐含量≤5ppm；愈创薁紫外透过率：≥95.0；水中不溶物：滤纸上无残留。本发明使用的产品为天津顶硕药业股份有限公司生产的产品。
优选的，本发明专利所述的薄荷脑为食品级，透明晶体，含量99％以上，砷含量≤3ppm，铅含量≤1ppm，重金属含量≤10ppm，本专利所述的薄荷脑为市售商品。
【具体实施方式】
为了更进一步的说明本发明的目的、技术方案和优点，我们结合以下具体实施例来阐述本发明，这些实施例仅为了更好的说明本发明专利，而不用于限制本发明范围，基于本发明中的实施例，本领域的技术人员在没有做出创造性的情况下所得到的其他所有实施方式均属于本发明所保护的范围。如在本发明专利基础配方的基础上，不管是将其制作成液体，还是粘稠膏体以及啫喱凝胶等类似产品均属于本发明的保护范围。实施例中未注明具体条件的实验方法，通常按照常规条件执行。
实施例1(以下均为重量份)
护理液制备方法如下：
步骤一：将2份茶皂素搅拌溶解于20份的纯净水中；步骤二：将0.05份愈创木精油和0.05份薄荷脑溶解于0.2份的无水乙醇中；步骤三：将0.5份乳香提取物、0.2份薁磺酸钠加入到10份的纯净水中，搅拌至完全溶解。将步骤二、三的溶液加入步骤一所得的溶液中，再加入剩余67份的纯净水搅拌均匀即可制备得到护理液。
实施例2
护理液制备方法如下：
步骤一：将10份茶皂素搅拌溶解于20份的纯净水中；步骤二：将1份愈创木精油加入到2.5份的无水乙醇中；步骤三：将5份乳香提取物、0.01份薁磺酸钠加入到20份的纯净水中，搅拌至完全溶解。将步骤二、三的溶液加入步骤一所得的溶液中，再加入剩余41.4份的纯净水，搅拌均匀即可制备得到护理液。
实施例3
护理液制备方法如下：
步骤一：将5份月桂酰基谷氨酸钠搅拌溶解于20份的纯净水中；步骤二：将1.5份愈创木精油、0.1份薄荷脑加入到3份的无水乙醇中；步骤三：将2份乳香提取物、0.5份薁磺酸钠加入到20份的纯净水中，搅拌至完全溶解。将步骤二、三的溶液加入步骤一所得的溶液中，再加入剩余47.9份的纯净水，搅拌均匀即可制备得到护理液。
实施例4
护理液制备方法如下：
步骤一：将8份椰油酰谷氨酸钠搅拌溶解于15份的纯净水中；步骤二：将 2份愈创木精油、0.15份薄荷脑加入到5份的无水乙醇中；步骤三：将0.05份乳香提取物、1份薁磺酸钠加入到10份的纯净水中，搅拌至完全溶解。将步骤二、三的溶液加入步骤一所得的溶液中，再加入剩余58.8份的纯净水，搅拌均匀即可制备得到护理液。
实施例5
护理液制备方法如下：
步骤一：将7重量份的茶皂素和椰油酰甘氨酸钾的混合物(其中两者重量比为3∶4)搅拌溶解于15份的纯净水中；步骤二：将0.5份愈创木精油、0.2份薄荷脑加入到2份的无水乙醇中；步骤三：将3份乳香提取物、0.3份薁磺酸钠加入到10份的纯净水中，搅拌至完全溶解。将步骤二、三的溶液加入步骤一所得的溶液中，再加入剩余62份的纯净水，搅拌均匀即可制备得到护理液。
【产品性能验证】
本发明新型护理洗液，抑菌效果好，抗炎症性能优异，经过人体试用试验，也获得了令人满意的结果。
抑菌效果测试：测试菌种为金黄色葡萄球菌、大肠杆菌、白色念珠菌。试验方法：参照中华人民共和国国家标准GB15797-2002“一次性使用卫生用品卫生标准”中附录C4″溶出性抗(抑)菌产品抑菌性能试验方法。”进行检测。测试结果如表1：
表1.实施例抑菌测试效果
抗炎症效果测试：采用MTT法检测清洁护理液对小鼠巨噬细胞生长的影响来测试其抗炎症效果。主要材料：小鼠巨噬细胞RAW264.7(来自中国医学科学院基础医学研究所细胞资源中心)，实施例4的护理液，小鼠前列腺素E2(PGE2)ELISA 检测试剂盒、小鼠肿瘤坏死因子-α(TNF-α)ELISA检测试剂盒、脂多糖(LPS)。
将RAW264.7细胞密度调整到5*105/ml，分别加入对照组(无血清培养基)，护理液组(100μg/ml的护理液及1μg/ml的LPS)，接种于96孔细胞培养板中，每孔1000μl，置于37℃、5％CO2细胞培养箱中培养18小时，于LPS刺激18小时后收集细胞上清液，按照ELISA试剂盒说明书进行PGE2检测，计算抑制率。
对LPS刺激RAW264.7细胞释放TNF-α的影响，分别为对照组(无血清培养基)，护理液组(100μg/ml的护理液及1μg/ml的LPS)，LPS刺激18小时候收集细胞上清液，按ELISA试剂盒说明书操作要求进行TNF-α检测，计算抑制率，记为抑制率2.
结果如表2：
表2.护理液对炎症细胞抑制率试验结果
| 成分 | 护理液 | 对照组 |
| 抑制率1(％) | 92.8 | 24.5 |
| 抑制率2(％) | 90.6 | 23.1 |
从抑制率1和抑制率2的数据分析可知，说明了护理液能有效抑制细胞炎症因子的释放，具有良好的抗炎功效。
为了进一步验证本发明的功效，我们选用实施例4的护理液做了如下人体试用试验：筛选了24-50岁的30名受试者进行测试，要求在两个月内连续使用护理液清洗私密处。期间没有一例出现任何不良反应的案例。而且其中有20名左右的受试者本来患有不同程度的肌肤瘙痒，白带多，阴道红肿疼痛等炎症性反应，使用本发明实施例4的护理液后，白带减少，红肿疼痛全部痊愈，不良体味消失，私密处感觉舒适清爽。有两名50岁阴道干涩女性，在使用本品一段时间后，干涩症状好转，自述性生活愉悦度得到了有效提升。
测试表明本发明新型护理洗液具有优异的抗菌消炎功能，能有效促进细胞组织愈合再生，对损伤的粘膜溃疡有很好的改善效果，能消肿止疼，解毒生肌，还可以调整人体体液分泌，促进人体生殖系统功能恢复。且采用温和亲肤的茶皂素和氨基酸类表面活性剂，具有抗过敏作用。尤其适用于性生活活跃人群天天养护清洁。效果优异。
Claims (11)
1.一种具有促进粘膜损伤及炎症修复、调节体液分泌、除味护肤等功能的护理洗液，其特征在于包括以下质量分数的各组分：
2.如权利要求书1所述的表面活性剂可以是茶皂素，也可以是氨基酸表面活性剂，还可以使两者以任何比例混合的混合物。
3.如权利要求书2所述的茶皂素其特征为活性物含量≥75％，颜色浅黄色，1％水溶液透明，无沉淀，无上浮物，水分含量小于5％，细度100目以上。
4.如权利要求书2所述的氨基酸表面活性剂，是指包括椰子油(或者月桂油或者棕榈油)的氨基酸(比如谷氨酸、甘氨酸等)盐(钠盐、钾盐、三乙醇胺盐)类的一系列表面活性剂。氨基酸表面活性剂基本构成＝油脂+酰+XX氨酸+XX盐。油脂有：月桂、肉豆蔻、椰油、棕榈、硬脂等；氨酸有：谷氨酸、甘氨酸、丙氨酸、精氨酸、肌氨酸等；盐有：钠盐、钾盐、三乙醇胺盐等。如：肉豆蔻酰谷氨酸钠、椰油酰甘氨酸钾、椰油酰精氨酸乙酯盐、月桂酰肌氨酸钠等等。
5.如权利要求书1所述乳香及其提取物其特征为含量为95％的乳香提取物粉体，粒径为80目。
6.如权利要求书1所述的薁磺酸钠，化学名称：1，4-二甲基-7-异丙基薁-3-磺酸钠，别名：愈创木薁磺酸钠，水溶性薁，呱仑酸钠，甘油磷酸二钠盐五水合物，AZ，Azulene。英文名：Sodium Guaiazulene Sulfonate或Sodium Azulene Sulfonate简称：SGS。CAS：6223-35-4，其特征在于纯度为98％以上的产品。
7.如权利要求书6所述的薁磺酸钠，其特征在于可以是化妆品级、也可以是医药级的，其中优选为化妆品级的。
8.如权利要求书6所述的薁磺酸钠，其特征在于产品中重金属含量：≤20ppm；砷盐含量≤5ppm；愈创薁紫外透过率：≥95.0；水中不溶物：滤纸上无残留。
9.如权利要求书1所述的薄荷脑也叫薄荷醇，系由薄荷的叶和茎中所提取，白色晶体，分子式C10H20O。
10.如权利要求书9所述的薄荷脑，其特征为食品级透明晶体，含量99％以上，砷含量≤3ppm，铅含量≤1ppm，重金属含量≤10ppm。
11.如权利要求书1所述基液体系由纯净水和无水乙醇构成。其特征为微量的无水乙醇和纯净水。其中无水乙醇量为权利要求书1中愈创木精油和薄荷脑重量份的2-2.5倍。其余部分为纯净水。
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