CN111568970A - 治疗脊柱损伤性截瘫的药物 - Google Patents

治疗脊柱损伤性截瘫的药物 Download PDF

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CN111568970A
CN111568970A CN202010599414.6A CN202010599414A CN111568970A CN 111568970 A CN111568970 A CN 111568970A CN 202010599414 A CN202010599414 A CN 202010599414A CN 111568970 A CN111568970 A CN 111568970A
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吴猛
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Abstract

本发明公开了几种治疗脊柱损伤性截瘫不同时期的药物，几种药物由自杜仲，川续断，生地，赤芍，当归尾，牡丹皮，桃仁，延胡索，肉桂，乌药，红花，大黄，乳香，没药，补骨脂，土元，地龙，远志，枳壳，骨碎补，苏木，甘草，厚朴，独活，桑寄生，威灵仙，鹿含草，狗脊中的多味中药制备而成。本发明提供的几种药物的总有效率100％，达到临床治愈在95％以上，采用全中药配方，服用方便，副作用小。

Description

治疗脊柱损伤性截瘫的药物
技术领域
本发明涉及中药技术领域，具体涉及治疗脊柱损伤性截瘫的药物。
背景技术
目前医院对脊柱损伤病人只作了一下内固定而已，它反而对骨骼生长，筋络、神经恢复有着相反的作用，会引起软组织增生，粘连，水肿增加，使得脊髓神经里的瘀血，水肿更不容易消散，更让双脚麻木加重，导致肌肉萎缩，马尾神经麻痹更不能恢复，所以现代医院治疗截瘫病人几乎不能康复。
发明内容
本发明的目的是提供一种能治疗脊柱损伤性截瘫的药物。
为解决上述技术问题，本发明采用如下技术方案：
本发明提供以下几种治疗不同时期脊柱损伤性截瘫的药物：
1、脊柱损伤急性期，由以下重量比的原料制备而成：杜仲1-3份，赤芍1-2份，当归尾1-2份，川续断1-2份，桃仁1-2份，红花1-2份，乳香1-2份，没药1-2份，土元1-2份，地龙1-3份，生地1-2份，牡丹皮1-2份。
优选地，如患者大小便闭塞，可增加大黄1-2份，枳壳1-2份，木通1-2份。
优选地，如患者大小便失禁，可增加远志1-2份。
优选地，如患者腹胀闷痛，还可增加延胡索1-2份，木香1-2份。
2、截瘫病稳定期治疗药物，由以下重量比的原料制备而成：杜仲1-3份，川续断1-2份，赤芍1-2份，当归尾1-2份，延胡索1-2份，肉桂1-2份，乌药1-2份，大黄1-2份，枳壳1-2份，乳香1-2份，没药1-2份，补骨脂1-2份，土元1-2份，地龙1-3份，骨碎补1-3份。
3、截瘫病恢复期治疗药物，由以下重量比的原料制备而成：苏木1-2份，杜仲1-3份，补骨脂1-2份，川续断1-2份，生地1-2份，赤芍1-2份，当归尾1-2份，骨碎补1-2份，肉桂1-2份，乌药1-2份，威灵仙1-2份，狗脊1-2份。
4、截瘫病恢复后期治疗药物，由以下重量比的原料制备而成：威灵仙1-2份，鹿含草1-2份，狗脊1-2份，独活1-2份，桑寄生1-2份，地龙1-3份，赤芍1-2份，生地1-2份，当归尾1-2份，杜仲1-2份，乌药1-2份，骨碎补1-2份，补骨脂1-2份，土元1-2份。
用药方式：一天三次煎内服，一次150至200毫升。
本发明的有益效果在于：本发明提供的几种药物的总有效率100％，达到临床治愈在95％以上，采用全中药配方，服用方便，副作用小。
以下结合本发明中主要成分对有益效果作进一步说明：
杜仲，【性味】甘微辛，温。【功用主治】补肝肾，强筋骨，安胎。治腰脊酸疼，足膝痿弱，小便余沥，阴下湿痒，胎漏欲堕，胎动不安，高血压。
川续断，苦、甘、辛，微温。归肝、肾经。1.补肝益肾：用于肝肾不足、血脉不利的腰膝酸软或风湿痹痛等，如(<和剂局方>续断丸)。2.跌打损伤：用于筋骨折损，有通利血脉、接骨疗伤的作用，常配当归，川芎，乳香，没药，三七，杜仲，牛膝，骨碎补等。
生地，性味：甘、苦、寒。功能：滋阴、凉血。主治：阴虚发热，热病伤阴，烦渴、骨蒸，斑疹，吐衄下血，妇女月经不调，胎动不安等症。
赤芍，性味：酸、苦、微寒。功能：清泄肝火，散瘀活血，止痛。主治：月经不调，瘀滞腹痛，经闭徵瘕，痈肿疮毒，关节肿痛，胸胁疼痛。
当归，【性味】甘辛，温。【功用主治】补血和血，调经止痛，润燥滑肠。治月经不调，经闭腹痛，百瘕结聚，崩漏；血虚头痛，眩晕，痿痹；肠燥便难，赤痢后重；痈疽疮窃，跌扑损伤。
牡丹皮，【性味】辛苦，凉。【功用主治】清热，凉血，和血，消瘀。治热入血分，发斑，惊痫，吐、衄、便血，骨蒸劳热，经闭，癥瘕，痈疡，扑损。
桃仁，性味：苦、甘、平。功能：活血行瘀，润燥滑肠。主治：经闭徵瘕，蓄血，腹痛，外伤瘀血及肠痈，肠燥便秘。
延胡索，【性味】辛苦，温。【功用主治】活血，散瘀，理气，止痛。治心腹腰膝诸痛，月经不调，百瘕，崩中，产后血晕，恶露不尽，跌打损伤。
肉桂，【性味】辛甘，热，【功用主治】补元阳，暖脾胃，除积冷，通血脉。治命门火衰，肢冷脉微，亡阳虚脱，腹痛泄泻，寒疝奔豚，腰膝冷痛，经闭百瘕，阴疽，流注，及虚阳浮越，上热下寒。
乌药，【性味】辛，温。【功用主治】顺气，开郁，散寒，止痛。治气逆胸腹胀痛，宿食不消，反胃吐食，寒疝，脚气，小便频数。
红花，性味：辛、温。功能：破瘀、活血、通经。主治：经血不调，产后腹痛，徵瘕，外伤瘀血仲痛，痈疽肿痛等症。
大黄，【性味】苦，寒。【功用主治】泻热毒，破积滞，行瘀血。治实热便秘，谵语发托，食积痞满，痢疾初起，里急后重，瘀停经闭，百瘕积聚，时行热疫，暴眼赤痛，吐血，衄血，阳黄，水肿，淋浊，溲亦，痈疡肿毒，疔疮，汤火伤。
乳香，【性味】辛苦，温。【功用主治】调气活血，定痛，追毒。治气血凝滞、心腹疼痛，痈疮肿毒，跌打损伤，痛经，产后瘀血刺痛。
没药，【性味】苦，平。【功用主治】散血去瘀，消肿定痛。治跌损，金疮，筋骨，心腹诸痛，百瘕，经闭，痈疽肿痛，痔漏，目障。
补骨脂，【性味】辛，温。【功用主治】补肾助阳。治肾虚冷泻，遗尿，滑精，小便频数，阳痿，腰膝冷痛，虚寒喘嗽。外用治白癜风。
土元，【性味与归经】咸，寒；有小毒。归肝经。【功能与主治】破瘀血，续筋骨。用于筋骨折伤，瘀血经闭，症瘕痞块。
地龙，性味：咸、寒。功能：清热、镇痉、利尿、解毒。主治：热病惊狂，风湿性关节炎、半身不遂、小儿惊风、小便不同；外用涂丹毒漆疮等。
远志，【性味】苦辛，温。【功用主治】安神益智，祛痰，解郁。治惊悸，健忘，梦遗，失眠，咳嗽多痰，痈疽疮肿。
枳壳，【性味】苦辛，凉。【功用主治】破气，行痰，消积。治胸膈痰滞，胸痞，胁胀，食积，噫气，呕逆，下痢后重，脱肛，子宫脱垂。
骨碎补，【性味】苦，温。【功用主治】补肾，活血，止血。治肾虚久泻及腰痛，风湿痹痛，齿痛，耳鸣，跌打闪挫、骨伤，阑尾炎，斑秃，鸡眼。
苏木，【性味】甘咸，平。【功用主治】行血，破瘀，消肿，止痛。治妇人血气心腹痛，经闭，产后瘀血胀痛喘急，痢疾，破伤风，痈肿，扑损瘀滞作痛。
甘草，【性味】甘，平。【功用主治】和中缓急，润肺，解毒，调和诸药。炙用，治脾胃虚弱，食少，腹痛便溏，劳倦发热，肺痿咳嗽，心悸，惊痫；生用，治咽喉肿痛，消化性溃疡，痈疽疮疡，解药毒及食物中毒。
厚朴，【性味】苦辛，温。【功用主治】温中，下气，燥湿，消痰。治胸腹痞满胀痛，反胃，呕吐，宿食不消，痰饮喘咳，寒湿泻痢。
独活，【性味】辛苦，温。【功用主治】祛风，胜湿，散寒，止痛。治风寒湿痹，腰膝酸痛，手脚挛痛，慢性气管炎，头痛，齿痛。
桑寄生，【性味】苦甘，平。【功用主治】补肝肾，强筋骨，除风湿，通经络，益血，安胎。治腰膝酸痛，筋骨痿弱，偏枯，脚气，风寒湿痹，胎漏血崩，产后乳汁不下。
威灵仙，【性味】辛咸，温，有毒。【功用主治】祛风湿，通经络，消痰涎，散癖积。治痛风、顽痹、腰膝冷痛，脚气，疟疾，百瘕积聚，破伤风，扁桃体炎，诸骨鲠咽。
狗脊，【性味】苦甘，温。【功用主治】补肝肾，除风湿，健腰脚，利关节。治腰背酸疼，膝痛脚弱，寒湿周痹，失溺，尿频，遗精，白带。
具体实施方式
下面将结合本发明实施例中对本发明的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
实施例1，治疗脊柱损伤急性期的药物，由以下重量比的原料制备而成：杜仲1份，赤芍1份，当归尾1份，川续断1份，桃仁1份，红花1份，乳香1份，没药1份，土元1份，地龙1份，生地1份，牡丹皮1份。
实施例2
治疗脊柱损伤急性期的药物，由以下重量比的原料制备而成：杜仲3份，赤芍2份，当归尾2份，川续断2份，桃仁2份，红花2份，乳香2份，没药2份，土元2份，地龙3份，生地2份，牡丹皮2份。
实施例3
治疗脊柱损伤急性期的药物，由以下重量比的原料制备而成：杜仲3份，赤芍2份，当归尾2份，川续断2份，桃仁2份，红花2份，乳香2份，没药2份，土元2份，地龙3份，生地2份，牡丹皮2份，大黄1-2份，枳壳2份，木通2份。
实施例4
治疗脊柱损伤急性期的药物，由以下重量比的原料制备而成：杜仲1份，赤芍1份，当归尾1份，川续断1份，桃仁1份，红花1份，乳香1份，没药1份，土元1份，地龙1份，生地1份，牡丹皮1份，远志1份。
实施例5
治疗脊柱损伤急性期的药物，由以下重量比的原料制备而成：杜仲3份，赤芍2份，当归尾2份，川续断2份，桃仁2份，红花2份，乳香2份，没药2份，土元2份，地龙3份，生地2份，牡丹皮2份，延胡索2份，木香2份。
实施例6
截瘫病稳定期治疗药物，由以下重量比的原料制备而成：杜仲1份，川续断1份，赤芍1份，当归尾1份，延胡索1份，肉桂1份，乌药1份，大黄1份，枳壳1份，乳香1份，没药1份，补骨脂1份，土元1份，地龙1份，骨碎补1份。
实施例7
截瘫病稳定期治疗药物，由以下重量比的原料制备而成：杜仲3份，川续断2份，赤芍2份，当归尾2份，延胡索2份，肉桂2份，乌药2份，大黄2份，枳壳2份，乳香2份，没药2份，补骨脂2份，土元2份，地龙3份，骨碎补3份。
实施例8
截瘫病恢复期治疗药物，由以下重量比的原料制备而成：苏木1份，杜仲1份，补骨脂1份，川续断1份，生地1份，赤芍1份，当归尾1份，骨碎补1份，肉桂1份，乌药1份，威灵仙1份，狗脊1份。
实施例9
截瘫病恢复期治疗药物，由以下重量比的原料制备而成：苏木2份，杜仲3份，补骨脂2份，川续断2份，生地2份，赤芍2份，当归尾2份，骨碎补2份，肉桂2份，乌药2份，威灵仙2份，狗脊2份。
实施例10
截瘫病恢复后期治疗药物，由以下重量比的原料制备而成：威灵仙1份，鹿含草1份，狗脊1份，独活1份，桑寄生1份，地龙1份，赤芍1份，生地1份，当归尾1份，杜仲1份，乌药1份，骨碎补1份，补骨脂1份，土元1份。
实施例11
截瘫病恢复后期治疗药物，由以下重量比的原料制备而成：威灵仙2份，鹿含草2份，狗脊2份，独活2份，桑寄生2份，地龙3份，赤芍2份，生地2份，当归尾2份，杜仲2份，乌药2份，骨碎补2份，补骨脂2份，土元2份。
临床实验数据：
(1)脊柱损伤急性期患者216例(脊柱损伤后生命体诊正常，损伤部位以下麻木无知觉，双下肢不能动作)，其中，有腰椎压缩性骨折69例，胸椎骨裂95例，爆裂性骨折46例，有4例颈椎骨折，有2例轻微压迫脊髓神经；用药7-15天后，身体能活动着力，能使脊髓神经的瘀血，水肿及脊柱两旁的软组织，筋络等促渐消散，舒通。
(2)截瘫病稳定期患者154例(脊柱损伤后引起截瘫，治疗一段时间后各种症状都有恢复)，用药7-15天后，身体能活动着力，能使脊髓神经的瘀血，水肿及脊柱两旁的软组织，筋络等促渐消散，舒通。
(3)截瘫恢复期患者19例，用药7-15天后，所有19名患者可侧身，站立，跪立，迈步，提跨，转跨，下蹬，扶架行走。
(4)截瘫病恢复后期患者96例，(截瘫治疗段时后，能动作及行走，双脚容易疲软，肿胀，麻木等)，有7例双脚严重无力促渐恢复行动基本能自理。
显然，本领域的技术人员可以对本发明进行各种改动和变型而不脱离本发明的精神和范围。这样，倘若本发明的这些修改和变型属于本发明权利要求及其等同技术的范围之内，则本发明也意图包含这些改动和变型在内。

Claims (7)

1.脊柱损伤急性期治疗药物，其特征在于，由以下重量比的原料制备而成：杜仲1-3份，赤芍1-2份，当归尾1-2份，川续断1-2份，桃仁1-2份，红花1-2份，乳香1-2份，没药1-2份，土元1-2份，地龙1-3份，生地1-2份，牡丹皮1-2份。
2.如权利要求1所述的脊柱损伤急性期治疗药物，其特征在于，还包括大黄1-2份，枳壳1-2份，木通1-2份。
3.如权利要求1所述的脊柱损伤急性期治疗药物，其特征在于，还包括远志1-2份。
4.如权利要求1所述的脊柱损伤急性期治疗药物，其特征在于，还包括延胡索1-2份，木香1-2份。
5.截瘫病稳定期治疗药物，其特征在于，由以下重量比的原料制备而成：杜仲1-3份，川续断1-2份，赤芍1-2份，当归尾1-2份，延胡索1-2份，肉桂1-2份，乌药1-2份，大黄1-2份，枳壳1-2份，乳香1-2份，没药1-2份，补骨脂1-2份，土元1-2份，地龙1-3份，骨碎补1-3份。
6.截瘫病恢复期治疗药物，其特征在于，由以下重量比的原料制备而成：苏木1-2份，杜仲1-3份，补骨脂1-2份，川续断1-2份，生地1-2份，赤芍1-2份，当归尾1-2份，骨碎补1-2份，肉桂1-2份，乌药1-2份，威灵仙1-2份，狗脊1-2份。
7.截瘫病恢复后期治疗药物，其特征在于，由以下重量比的原料制备而成：威灵仙1-2份，鹿含草1-2份，狗脊1-2份，独活1-2份，桑寄生1-2份，地龙1-3份，赤芍1-2份，生地1-2份，当归尾1-2份，杜仲1-2份，乌药1-2份，骨碎补1-2份，补骨脂1-2份，土元1-2份。
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Application publication date: 20200825

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