CN1115647A - Compound Artemisia rupestris granule and its prepn - Google Patents

Abstract

Compound Artemisia rupestris granule is prepared with Artemisia rupestris, isatis indigotica, Radix isatidis, etc. With the functions of antipyresis, detoxication, antisepsis and antiphlogosis, the said granule has excellent curative effect on cold, acute and chronic tonsillitis and pneumonia. Furthermore, it has certain effect on hepatitis as supplement medicine.

Description

Compound Artemisia rupestris granule and preparation method thereof

The present invention relates to a kind of Chinese medicine preparation, particularly a kind of compound granules.

At present the medicine of state's internal therapy flu have that flu is clear, GANMAOTONG and Radix Isatidis electuary etc., wherein clear, the GANMAOTONG of flu is the compound preparation of Chinese medicine and western medicine combination, the side effect that has tangible Western medicine to be produced.And flu is clear, the weak curative effect of Radix Isatidis electuary.

The purpose of this invention is to provide a kind of heat-clearing and toxic substances removing, anti-inflammation, antianaphylactic Chinese medicine preparation.

Weight of formulation umber proportioning of the present invention is:

1 part of Herba Achilleae

Folium Isatidis 3/5-5/3 part

Radix Isatidis 3/5-5/3 part

Also can contain an amount of sucrose and/or dextrin in the electuary of the present invention.

The preparation method of described electuary is filtered for Herba Achilleae, Folium Isatidis, Radix Isatidis three flavor medicines are decocted with water, and concentrated filtrate adds ethanol precipitation, gets supernatant and reclaims ethanol, is condensed into clear paste, makes granule, gets product after the drying.

Electuary treatment flu of the present invention, the auxiliary treatment of acute and chronic tonsillitis and pneumonia and hepatitis etc. have curative effect and stronger anti-virus ability preferably, and safe in utilization, without any side effects.

Herba Achilleae in the electuary of the present invention, acrid in the mouth, tepor, delicate fragrance such as Artemisia, the multiple pathogenic factor in the exterior that looses of hot flavor, qi and blood circulation promotion, go to stagnate, warm in nature can but trembling with fear, so to the diseases caused by exogenous pathogenic factor exterior syndrome, QI and blood stasis all can be treated; Folium Isatidis, but bitter, property Great Cold, GUIXIN lung, stomach through, bitterness eliminating fire and detoxication, cold in nature and can heat clearing away; Radix Isatidis, bitter in the mouth, cold in nature, go into cardiopulmonary two warps, but the bitterness eliminating fire and detoxication, but heat clearing away cold in nature, especially to cardiopulmonary two through heat syndrome, the time row epidemic disease poison with it produce effects is arranged.Each all function of described each composition is closed the side of forming, and complements each other, and has synergism.Treat the effect of flu below with clinical observation on the therapeutic effect explanation electuary of the present invention.

Adopting two at random methods of educating to compare treatment observes.

One, alternative

(1) case is selected: (1) must have 3 above symptoms such as pharyngalgia, dry pharynx, itching throat, nasal obstruction, watery nasal discharge, sneeze, fear of cold, heating, head-body-pain; (2) pain journey at 3 days with interior person.

(2) following situation is not as the object of observation: (1) generates heat above 39 ℃; (2) pharyngeal have a suppuration kitchen range; (3) there is abnormal shade in fluoroscopy of chest pulmonary; (4) auscultation of lung has dried, moist rale.

(3) case load: observe flu patient 488 examples altogether, group 215 examples of wherein catching a cold I number, male's 95 examples, women's 120 examples, wherein Uygurs's 23 examples are breathed out family's 4 examples, the Hui ethnic group's 6 examples, Xibe's 1 example; Catch a cold and organize 136 examples II number, male's 62 examples, women's 74 examples, wherein Uygurs's 27 examples are breathed out family's 4 examples, the Hui ethnic group's 5 examples; Catch a cold and organize 137 examples, male's 63 examples, women's 74 examples, wherein Uygurs's 26 examples III number, breathe out family's 3 examples, the Hui ethnic group's 7 examples, age 15-70 year, I number group of mean age flu is 32.9 2 ± 11.84, and the II number group of catching a cold is 31.1 2 ± 14.33, and the III number group of catching a cold is 31.53 ± 13.95.

Two, methods of clinical observation: by open observation of outpatient service prescription on individual diagnosis order randomized, double-blind

(1) medicine: establish three administration groups: catch a cold I number (compound Artemisia rupestris granule 2 bag+flu IV numbers 1 bag), catch a cold II number (Radix Isatidis electuary 2 bag+flu IV numbers 1 bag) (the clear 1 bottle+flu of catching a cold IV number 1 bag) [catching a cold IV number is C. P. P. C (1 bag of 0.3g*18 sheet)] of catching a cold III number.

(2) method of administration: each administration group: I, II number group (2 bags of electuaries+flu IV number 1 slice/time); III number group (4 of coated tablets+flu IV number 1 slice/time), taken medicine 3 days continuously at every day three times.

(3) observation item:

1, clinical symptoms: pharyngalgia, dry pharynx, itching throat, nasal obstruction, watery nasal discharge, sneeze, fear of cold, heating, head-body-pain

2, sign: pharyngeal congestion

3, check: survey body temperature, throat inspection

(4) observe: complete observation and registration are above every during prescription on individual diagnosis and after taking medicine 3 days

Three, efficacy evaluation:

Cure: medication is after 3 days, the complete obiteration of clinical symptoms sign.

Produce effects: medication is after 3 days, and the clinical symptoms sign disappears substantially or obviously alleviates.

Effectively: medication is after 3 days, and the clinical symptoms sign has and alleviates.

Invalid: medication is after 3 days, and the clinical symptoms sign is as treating preceding or increasing the weight of.

Four, result:

(1) statistical result of flu I short term effect sees Table 1

I number clinical short term effect of table 1 flu

Effect	Cure	Produce effects	Effectively	Invalid	Add up to
						The example number	??89	??73	??45	??6	?215

Cure: 41.4%; Produce effects: 34.88%; Effectively: 20.93%; Total effective rate is 97.2%.

(2) the clinical control treatment is observed: the results are shown in Table 2

Three administration groups of table 2 clinical control treatment observed result

II number flu of I number flu of curative effect grouping flu III number	The example number					Corresponding percentage rate
											Cure 89 (56) 19 (36) 20 (36)	Produce effects 75 (64) 40 (41) 31 (41)	Effective 45 (73) 57 (46) 64 (47)	Invalid 6 (21) 20 (13) 22 (13)	Add up to 215 136 137	Cure 41.4 13.97 14.6	Produce effects 34.88 29.41 22.63	Effective 20.93 41.91 46.72	Countless 2.79 14.71 16.06	Add up to 100 100 100

Through X ²Check: P＜0.05, illustrate that flu I, II, III three's curative effect are variant, and learn processing P＞0.05 for II and III number by statistics, illustrate that both curative effect difference are meaningless, compare cure rate and obvious effective rate merely, I number the curative effect of catching a cold is best.

(3) catch a cold I number relatively: see Table 3 tables 3 and catch a cold I number relatively to dissimilar flu curative effect effects to dissimilar flu curative effect effects

Curative effect grouping plain edition flu simple type influenza	The example number					Corresponding percentage rate
											Cure 81 8	Produce effects 56 19	Effective 25 20	Invalid 33	Add up to 165 50	Cure 49.09 16	Produce effects 33.94 38.0	Effective 15.15 40.0	Countless 1.82 6.0	Add up to 100 100

Through X ²Check P＜0.05 illustrate that flu I number is variant to two types curative effect, compares the better efficacy that plain edition is caught a cold merely.

(4) the I number comparison to the effect of light, the heavy patient's curative effect of plain edition flu of flu sees Table 4

Table 4 flu is caught a cold gently, is weighed the effect of patient's curative effect to plain edition I number and compares

Light disease (after date in the flu) serious symptom of plain edition flu (common cold initial stage)

Cure 61 20

Produce effects 22 34

Effective 5 20

Invalid 03

Add up to 88 77

Cure 69.32 29.97

Produce effects 25.0 44.18

Effective 5.83 25.97

Countless 0 3.8

Add up to 100 100

Through X ²Check, P＜0.05 illustrate that flu I number is variant to both curative effects, compares cure rate and obvious effective rate merely, catch a cold I number to the common cold initial stage aversion to cold feel cold, symptom best results such as head-body-pain, laryngopharynx swelling and pain, nasal obstruction thin nasal discharge, sneeze, dry cough.

Five, other: in clinical application, it is the displeased acceptance of tablet III number because of flu that quite a few patient is arranged, and after other had patient to reflect to take III number, sleepiness was denseer, and a few patients reflection flu II taste is sweet excessively.Yu Jun finds no obvious adverse reaction.

Six, brief summary: adopt the open observed result of randomized, double-blind method, show flu I, II, III number group therapeutic outcome variant (P＜0.05), wherein catching a cold has significant curative effect (97.2%) to flu patient doing well,improving I number, and effective to simple property influenza, especially to the disease curative effect the best just of catching a cold.

Further specify the present invention with embodiment below.

Embodiment

Get 1000 gram Herba Achilleaes, 1000 gram Folium Isatidiss, 1000 gram Radix Isatidiss, add water 1000-1500 gram, the intense fire heated and boiled is used slow fire instead and was kept 2-25 hour, filters with 100 mesh sieves; Add for the second time water 500-1000 gram, decocted 1.5-2 hour, filter with 100 mesh sieves, it is 1～1.50 (90-95 ℃) that merging filtrate, filtrate are concentrated into relative density, and weight is the 30-400 gram, room temperature to be chilled to, add equivalent ethanol and make precipitation (2-7 days), filter with 100 mesh sieves, filtrate is concentrated into the clear paste that relative density is 1.0-1.60 (60-65 a ℃), 1 part of qinghuo reagent, add cane sugar powder 5.5-6 part, 1 part in dextrin and adequate amount of ethanol are made granule, are drying to obtain.The finished product brown yellow granule, it is sweet to distinguish the flavor of, little hardship.Usage is that boiled water is taken after mixing it with water, a 15-30g, three times on the one.Sealed damp-proof is deposited.

Claims (3)

1, a kind of Chinese medicine preparation is characterized in that the parts by weight prescription is:

1 part of Herba Achilleae

Folium Isatidis 3/5-5/3 part

Radix Isatidis 3/5-5/3 part

2, preparation as claimed in claim 1 is characterized in that containing an amount of sucrose and or dextrin.

3, the preparation method of preparation as claimed in claim 1 or 2 is characterized in that Herba Achilleae, Folium Isatidis, Radix Isatidis are decocted with water, and filters, concentrated filtrate, adds ethanol precipitation, gets supernatant and reclaims ethanol, is condensed into clear paste, makes granule, promptly makes electuary after the drying.