CN111558012B - Traditional Chinese medicine composition for treating infantile bronchitis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating infantile bronchitis and preparation method thereof Download PDFInfo
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- CN111558012B CN111558012B CN202010629659.9A CN202010629659A CN111558012B CN 111558012 B CN111558012 B CN 111558012B CN 202010629659 A CN202010629659 A CN 202010629659A CN 111558012 B CN111558012 B CN 111558012B
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Abstract
The invention provides a traditional Chinese medicine composition for treating infantile bronchitis, which is prepared from the following medicinal materials in parts by weight: 12g of radix pseudostellariae, 6g of raw bighead atractylodes rhizome, 9g of poria cocos, 5g of liquorice, 9g of loquat leaf, 6g of thunberg fritillary bulb, 2g of bulbus fritillariae cirrhosae, 9g of adenophora tetraphylla, 9g of radix glehniae, 6g of exocarpium citri rubrum, 5g of platycodon grandiflorum, 9g of radix stemonae, 5g of pinellia ternate and 5g of almond; the preparation method of the traditional Chinese medicine composition comprises the following steps: (1) weighing 13 medicinal materials except the almond according to the weight ratio, and adding water for decocting; (2) decocting with direct fire, boiling with strong fire, boiling, maintaining slightly boiling state with slow fire, decocting twice, the first decoction needs 10-15 min from boiling, and the second decoction needs 8-10 min after boiling; (3) squeezing the residue, removing residues, filtering, mixing the decoctions, and administering twice; (4) weighing 5g of almonds, pulverizing into powder and taking with water; the traditional Chinese medicine composition has the effects of tonifying spleen and reducing phlegm, tonifying lung and nourishing lung, reducing swelling and resolving masses, eliminating dampness and reducing phlegm, moistening dryness and relieving cough, and has a good curative effect on treating the infantile bronchitis.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating infantile bronchitis and a preparation method thereof.
Background
The infantile bronchitis belongs to chronic nonspecific inflammation, appears in trachea, bronchial mucosa and surrounding tissues and is usually caused by repeated infection of bacteria and viruses, the disease is easily caused by small vasospasm ischemia of respiratory tract, temperature drop and body defense function drop, and the disease is also easily caused by chronic stimulation such as air pollution, smoke dust and the like, and in addition, a certain relation exists between the chronic bronchitis and allergic factors. The patient will have long-term and repeated cough accompanied by symptoms such as expectoration and asthma.
According to the traditional Chinese medicine, the lung, spleen and kidney are deficient, qi and blood are disordered, and phlegm stasis and obstruction of collaterals are the basic of repeated attack of the infantile asthma, and the coexistence of deficiency and excess is the main clinical characteristics of the remission stage. Bronchitis is usually common in infants under 2 years old, bronchitis patients can have symptoms of dyspnea, cough, asthma and the like, and after treatment of cough relieving, phlegm reducing, antibacterial drugs and the like, part of patients can also have repeated cough, so that the treatment effect is not obvious finally.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for treating infantile bronchitis and a preparation method thereof, and the traditional Chinese medicine composition has the effects of tonifying spleen and reducing phlegm, tonifying lung and nourishing lung, tonifying spleen and replenishing qi, eliminating dampness and reducing phlegm, moistening dryness and relieving cough, and reducing swelling and resolving masses.
The invention adopts the following technical scheme:
a traditional Chinese medicine composition for treating infantile bronchitis is prepared from the following medicinal materials in parts by weight: 12g of radix pseudostellariae, 6g of raw bighead atractylodes rhizome, 9g of poria cocos, 5g of liquorice, 9g of loquat leaf, 6g of thunberg fritillary bulb, 2g of bulbus fritillariae cirrhosae, 9g of adenophora tetraphylla, 9g of radix glehniae, 6g of exocarpium citri rubrum, 5g of platycodon grandiflorum, 9g of radix stemonae, 5g of pinellia ternate and 5g of almond.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) weighing 13 medicinal materials except semen Armeniacae amarum at a certain weight ratio, decocting in water 5-8 times of the medicinal materials or soaking in water 2-10cm above the medicinal materials;
(2) decocting with direct fire, boiling with strong fire, boiling, maintaining slightly boiling state with slow fire, decocting twice, the first decoction needs 10-15 min from boiling, and the second decoction needs 8-10 min after boiling;
(3) squeezing the residue, removing residues, filtering, mixing the decoctions, and administering twice;
(4) the almond is weighed and 5g is pulverized and taken with water.
Furthermore, the decocting apparatus is made of enamel ware and stainless steel, and a small amount of earthenware pot is selected.
Furthermore, the water for decoction is purified and softened drinking water or clean head water of natural rivers.
The medicinal properties and pharmacology of the selected medicinal materials are as follows:
radix pseudostellariae: tonify the spleen and lung, supplement qi and promote the production of body fluid. It is indicated for cough due to lung deficiency, poor appetite due to spleen deficiency, palpitation, edema, diabetes, and mental fatigue.
Raw rhizoma atractylodis macrocephalae: the rhizoma Atractylodis Macrocephalae is dried rhizome of Atractylodes macrocephala Koidz of Compositae. It enters spleen and stomach meridians, and is bitter, sweet and warm in nature. Has the functions of strengthening spleen, benefiting vital energy, eliminating dampness, inducing diuresis, stopping sweating and preventing miscarriage.
Tuckahoe, poria cocos: mainly treats dysuria; edema and fullness; cough with phlegm and fluid retention; vomiting; poor appetite due to spleen deficiency; diarrhea; palpitation and uneasiness; insomnia and amnesia; seminal emission is white and turbid.
Licorice root: can be used for treating heart-qi deficiency, cardiopalmus, intermittent pulse, deficiency of spleen and stomach qi, listlessness, debilitation, carbuncle, cellulitis, pyocutaneous disease, sore throat, asthma, cough, gastralgia, abdominal pain and acute pain of gastrocnemius muscle contracture.
Loquat leaf: has effects in clearing away lung heat, relieving cough, regulating stomach function, promoting urination, and quenching thirst. Has effects of treating lung heat phlegm cough, hemoptysis, epistaxis, and stomach heat emesis.
Thunberg fritillary bulb: can be used for treating cough due to wind-heat or phlegm-heat, lung abscess, purulent vomiting, scrofula, goiter, sore, carbuncle, and toxic swelling.
Tendril-leaved fritillary bulb: bulbus Fritillariae Cirrhosae has effects of moistening lung, relieving cough, eliminating phlegm, relieving asthma, clearing heat, and eliminating phlegm, and can be used for treating cough due to heat syndrome, such as cough due to wind-heat, cough due to dryness-heat, and cough due to lung-fire. Bulbus Fritillariae Cirrhosae has antitussive, expectorant, blood pressure lowering, and antibacterial effects.
Radix adenophorae: is used for nourishing yin, clearing away heat, moistening lung, eliminating phlegm, invigorating stomach, and promoting salivation. It is mainly indicated for chronic cough due to yin deficiency, tuberculosis cough with phlegm and blood, dry cough with little phlegm, deficiency heat and throat impediment, thirst due to body fluid consumption.
Radix glehniae: it can be used for treating dry cough due to lung dryness, body fluid impairment due to fever, and thirst.
Orange peel: is used for dispelling cold, eliminating dampness, promoting qi circulation and eliminating phlegm. Can be used for treating cough due to wind-cold evil, itching throat and excessive phlegm.
Balloon flower: is used for dispersing lung qi, relieving sore throat, eliminating phlegm, and expelling pus. Can be used for treating cough with excessive phlegm, chest distress, pharyngalgia, hoarseness, lung carbuncle, and purulent vomiting.
Stemona root: it can be used for moistening lung, keeping adverse qi downward, and relieving cough, and can be used for treating chronic cough, pulmonary tuberculosis cough, pertussis, and radix Stemonae preparata with lung moistening and cough relieving effects. Can be used for treating cough due to yin deficiency.
Pinellia ternata: dry dampness and resolve phlegm, check adverse rise of qi and arrest vomiting, relieve stuffiness and dissipate nodulation. Can be used for treating cough with asthma due to excessive phlegm, dizziness and palpitation due to phlegm and fluid retention, dizziness due to wind-phlegm, headache due to phlegm syncope, emesis, regurgitation, chest and gastric fullness, and globus hystericus; unprocessed for treating abscess and phlegm nodule.
Almond: moisten lung and relieve dyspnea.
The invention has the beneficial effects that:
according to the clinical manifestations of the infantile bronchitis, the infantile bronchitis can be classified as cough in the traditional Chinese medicine, the cause is spleen deficiency and phlegm dampness, the treatment is to strengthen spleen and reduce phlegm, tonify spleen and nourish lung, strengthen spleen and replenish qi, and use the source of dead phlegm; stemona and loquat leaves can relieve cough and reduce sputum; zhejiang fritillaria bulb, bulbus fritilariae, radix adenophorae and radix glehniae have the effects of nourishing lung, moistening dryness, reducing phlegm and resolving masses; pinellia ternate, exocarpium citri rubrum and platycodon grandiflorum have the effects of eliminating dampness, reducing phlegm and relieving cough; almond has the functions of depressing qi, eliminating phlegm, relieving cough and asthma; the traditional Chinese medicine composition is prepared from radix pseudostellariae, raw rhizoma atractylodis macrocephalae, poria cocos, liquorice, loquat leaf, thunberg fritillary bulb, adenophora tetraphylla, radix glehniae, exocarpium citri rubrum, platycodon grandiflorum, radix stemonae, pinellia ternate and almond, and through reasonable compatibility of the components, the effects of the raw materials generate a synergistic effect, the traditional Chinese medicine composition has the effects of tonifying spleen and reducing phlegm, tonifying lung and nourishing lung, relieving swelling and resolving masses, clearing damp and eliminating phlegm, moistening dryness and relieving cough, is combined with the raw materials, has good curative effect on treating infantile bronchitis, and is quick in curative effect.
Detailed Description
Example 1
A traditional Chinese medicine composition for treating infantile bronchitis is prepared from the following medicinal materials in parts by weight: 12g of radix pseudostellariae, 6g of raw bighead atractylodes rhizome, 9g of poria cocos, 5g of liquorice, 9g of loquat leaf, 6g of thunberg fritillary bulb, 2g of bulbus fritillariae cirrhosae, 9g of adenophora tetraphylla, 9g of radix glehniae, 6g of exocarpium citri rubrum, 5g of platycodon grandiflorum, 9g of radix stemonae, 5g of pinellia ternate and 5g of almond.
The preparation method of the traditional Chinese medicine composition for treating the infantile bronchitis comprises the following steps:
(1) weighing 13 medicinal materials except semen Armeniacae amarum at a certain weight ratio, decocting in water 5-8 times of the medicinal materials or soaking in water 2-10cm above the medicinal materials; the decocting apparatus is selected from enamel ware and stainless steel, and a small amount of earthenware pot is prepared; the water for decoction is purified and softened drinking water or clean upper source water of a natural river;
(2) decocting with direct fire, boiling with strong fire, boiling, maintaining slightly boiling state with slow fire, decocting twice, the first decoction needs 10-15 min from boiling, and the second decoction needs 8-10 min after boiling;
(3) squeezing the residue, removing residues, filtering, mixing the decoctions, and administering twice;
(4) the almond is weighed and 5g is pulverized and taken with water.
Example 2
A traditional Chinese medicine composition for treating infantile bronchitis is prepared from the following medicinal materials in parts by weight: 9g of radix stemonae, 5g of pinellia ternate, 5g of almond, 9g of adenophora tetraphylla, 9g of radix glehniae, 9g of loquat leaf, 6g of exocarpium citri rubrum and 5g of platycodon grandiflorum.
The preparation method of the traditional Chinese medicine composition for treating the infantile bronchitis comprises the following steps:
(1) weighing 7 medicinal materials except almond according to the weight ratio, adding water for decoction, wherein the water addition amount is 5-8 times of the medicinal materials or adding water to soak the medicinal materials for 2-10 cm; the decocting apparatus is selected from enamel ware and stainless steel, and a small amount of earthenware pot is prepared; the water for decoction is purified and softened drinking water or clean upper source water of a natural river;
(2) decocting with direct fire, boiling with strong fire, boiling, maintaining slightly boiling state with slow fire, decocting twice, the first decoction needs 10-15 min from boiling, and the second decoction needs 8-10 min after boiling;
(3) squeezing the residue, removing residues, filtering, mixing the decoctions, and administering twice;
(4) the almond is weighed and 5g is pulverized and taken with water.
Example 3
A traditional Chinese medicine composition for treating infantile bronchitis is prepared from the following medicinal materials in parts by weight: 12g of radix pseudostellariae, 6g of raw bighead atractylodes rhizome, 5g of liquorice, 9g of radix stemonae, 9g of loquat leaf, 5g of platycodon grandiflorum, 6g of exocarpium citri rubrum, 5g of pinellia ternate and 5g of almond.
The preparation method of the traditional Chinese medicine composition for treating the infantile bronchitis comprises the following steps:
(1) weighing 8 medicinal materials except almond according to the weight ratio, adding water for decoction, wherein the water addition amount is 5-8 times of the medicinal materials or adding water to soak the medicinal materials for 2-10 cm; the decocting apparatus is selected from enamel ware and stainless steel, and a small amount of earthenware pot is prepared; the water for decoction is purified and softened drinking water or clean upper source water of a natural river;
(2) decocting with direct fire, boiling with strong fire, boiling, maintaining slightly boiling state with slow fire, decocting twice, the first decoction needs 10-15 min from boiling, and the second decoction needs 8-10 min after boiling;
(3) squeezing the residue, removing residues, filtering, mixing the decoctions, and administering twice;
(4) the almond is weighed and 5g is pulverized and taken with water.
Example 4
A traditional Chinese medicine composition for treating infantile bronchitis is prepared from the following medicinal materials in parts by weight: 9g of adenophora tetraphylla, 9g of radix glehniae, 9g of loquat leaf, 6g of thunberg fritillary bulb, 2g of bulbus fritilariae, 12g of radix pseudostellariae, 6g of raw bighead atractylodes rhizome, 9g of poria cocos and 5g of liquorice.
The preparation method of the traditional Chinese medicine composition for treating the infantile bronchitis comprises the following steps:
(1) weighing the 9 medicinal materials according to the weight ratio, adding water for decocting, wherein the water adding amount is 5-8 times of the medicinal materials or adding water to soak the medicinal materials for 2-10 cm; the decocting apparatus is selected from enamel ware and stainless steel, and a small amount of earthenware pot is prepared; the water for decoction is purified and softened drinking water or clean upper source water of a natural river;
(2) decocting with direct fire, boiling with strong fire, boiling, maintaining slightly boiling state with slow fire, decocting twice, the first decoction needs 10-15 min from boiling, and the second decoction needs 8-10 min after boiling;
(3) squeezing the residue, removing residues, filtering, mixing the decoctions, and administering twice.
The efficacy of the traditional Chinese medicine composition for treating infantile bronchitis is proved in clinical application, and the treatment effect is as follows:
clinical research
1. General data
Selecting 600 children patients treated in the pond-inhabited green shade street traditional Chinese medicine clinic of Hangzhou Baoqian health management limited company and identified as spleen deficiency and phlegm dampness by the traditional Chinese medicine dialectical method from 2016 to 2019, wherein 470 children patients and 130 children patients are divided according to a random digital table method, and 120 patients of an observation group, a control group, a clinical group 1, a clinical group 2 and a clinical group 3 are respectively treated;
observation group: 72 male and 48 female, with age of 1-10 years, mean age of 7.5 + -1.8 years, mean course of disease of 12.0 + -6.5 months;
control group: 116 male and 4 female, with age of 1-10 years, mean age of 5.9 + -2.2 years, mean course of disease of 10.0 + -7.5 months;
clinical group 1: 104 male and 16 female, with age of 1-10 years, mean age of 6.1 + -1.8 years, mean course of disease of 9.0 + -6.5 months;
clinical group 2: 70 male and 50 female, wherein the age is 1-10 years, the average age is 7.3 +/-1.6 years, and the average course of disease is 11.0 +/-7.5 months;
clinical group 3: 108 men and 12 women, the age is 1-10 years, the average age is 6.3 plus or minus 2.2 years, and the average course of disease is 10.0 plus or minus 6.5 months;
no statistical significance in comparison of data among 5 children patients (P＞0.05) And has comparability.
2. Method of treatment
Observation group: the decoction of the traditional Chinese medicine composition prepared in the embodiment 1 of the invention is decocted by 100 mL with water every day and is taken warmly after 3 meals, wherein the almond is confected to be taken with powder, and the dosage of the medicine can be properly adjusted according to the age and the weight of a child patient;
control group: administering montelukast sodium (trade name of cis-well-natrin, manufactured by Moshadong company) to children patients of less than 5 years old, 1 time per night, 4mg each time, and orally; the children patients are more than or equal to 5 years old, 1 time per night, 5mg each time, and orally take;
clinical group 1: the decoction of the traditional Chinese medicine composition prepared in the embodiment 2 of the invention is decocted by 100 mL with water every day and is taken warmly after 3 meals, wherein the almond is confected to be taken with powder, and the dosage of the medicine can be properly adjusted according to the age and the weight of the sick children;
clinical group 2: the decoction of the traditional Chinese medicine composition prepared in the embodiment 3 of the invention is decocted by 100 mL with water every day and is taken warmly after 3 meals, wherein the almond is confected to be taken with powder, and the dosage of the medicine can be properly adjusted according to the age and the weight of the sick children;
clinical group 3: the decoction of the traditional Chinese medicine composition prepared in the embodiment 4 of the invention is decocted by 100-;
one course of treatment of the observation group, the control group, the clinical group 1, the clinical group 2 and the clinical group 3 is 4 weeks, 1 course of treatment is observed for each child patient, and when the half course of treatment is completed and the course of treatment is not completed, other patients who use other treatment because the course of treatment is not improved are invalid cases, and the patients who do not complete the half course of treatment are abscission cases.
3. Observation of therapeutic effects
Effective clinical symptoms: the sign of the disease is good, and the cumulative integral of the symptom is reduced by more than or equal to 30 percent;
ineffective clinical symptoms: the physical signs are not obviously improved or aggravated, and the cumulative integral of symptoms is reduced by less than 30 percent;
the clinical symptoms are healed: the physical signs basically disappear, and the cumulative integral of the symptoms is reduced by more than or equal to 95 percent;
significant clinical symptoms: the physical signs are obviously improved, and the cumulative integral of the symptoms is reduced by more than or equal to 70 percent.
4. Therapeutic results
The comparison of the therapeutic effects of the observation group, the control group, the clinical group 1, the clinical group 2 and the clinical group 3 is shown in table 1;
TABLE 15 comparison of clinical therapeutic effects of infant patients
| Group of | Number of examples | Recovery method | Show effect | Is effective | Invalidation | The total effective rate% |
| Observation group | 120 | 36 | 42 | 24 | 18 | 85.00 |
| Control group | 120 | 10 | 8 | 20 | 82 | 31.67 |
| Clinical group 1 | 120 | 25 | 28 | 20 | 47 | 60.83 |
| Clinical group 2 | 120 | 20 | 25 | 22 | 53 | 55.83 |
| Clinical group 3 | 120 | 25 | 26 | 27 | 42 | 65.00 |
The total effective rate of the observation group is 85.00 percent, which is higher than 31.67 percent of the control group, and the difference has statistical significance (P< 0.05); the clinical group 1, the clinical group 2 and the clinical group 3 used the traditional Chinese medicine decoction prepared in the embodiment 2, the embodiment 3 and the embodiment 4 respectively, the treatment effect of the traditional Chinese medicine decoction has a great difference from the treatment effect of the traditional Chinese medicine composition, and the curative effect of the components of the traditional Chinese medicine decoction is obviously better than that of other groups; the above treatment effects show that: the medicine has a remarkable treatment effect and is suitable for clinical popularization.
Claims (5)
1. A traditional Chinese medicine composition for treating infantile bronchitis is characterized by being prepared from the following medicinal materials in parts by weight: 12g of radix pseudostellariae, 6g of raw bighead atractylodes rhizome, 9g of poria cocos, 5g of liquorice, 9g of loquat leaf, 6g of thunberg fritillary bulb, 2g of bulbus fritillariae cirrhosae, 9g of adenophora tetraphylla, 9g of radix glehniae, 6g of exocarpium citri rubrum, 5g of platycodon grandiflorum, 9g of radix stemonae, 5g of pinellia ternate and 5g of almond.
2. The preparation method of the traditional Chinese medicine composition for treating infantile bronchitis according to claim 1, which is characterized by comprising the following steps:
(1) weighing 13 medicinal materials except the almond according to the weight ratio, and adding water for decocting;
(2) decocting with direct fire, boiling with strong fire, boiling, maintaining slightly boiling state with slow fire, decocting twice, the first decoction needs 10-15 min from boiling, and the second decoction needs 8-10 min after boiling;
(3) squeezing the residue, removing residues, filtering, mixing the decoctions, and administering twice;
(4) the almond is weighed and 5g is pulverized and taken with water.
3. The preparation method of the traditional Chinese medicine composition for treating infantile bronchitis according to claim 2, is characterized in that: the water addition amount in the step (1) is 5-8 times of the amount of the medicinal materials or the medicinal materials are soaked in water for 2-10 cm.
4. The preparation method of the traditional Chinese medicine composition for treating infantile bronchitis according to claim 2, is characterized in that: the water for decoction is purified and softened drinking water or clean head water of natural river.
5. The preparation method of the traditional Chinese medicine composition for treating infantile bronchitis according to claim 2, is characterized in that: the decocting apparatus is selected from enamelware or stainless steel product.
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