CN111544530A - 一种治疗血虚阳亢证头痛的复方中药 - Google Patents
一种治疗血虚阳亢证头痛的复方中药 Download PDFInfo
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Abstract
本发明涉及治疗血虚阳亢证头痛的复方中药，可有效解决疗效好的治疗血虚阳亢证头痛的用药问题，方法是，由川芎18‑30g、当归12‑18g、酸枣仁21‑30g、知母18‑30g、茯苓15‑21g、天麻15‑21g、白薇15‑21g、白蒺藜6‑10g和甘草6‑10g作原料药物制成，原料药物加水超过药面2‑3厘米，浸泡30分钟，先用大火煮沸，再用小火保持沸腾25‑30分钟，过滤；药渣再加水浸没药面，大火煮沸，再用小火保持沸腾25‑30分钟，过滤，合并两次滤液，混匀，即为成品。本发明原料丰富，组方科学合理，易生产制备，具有养血活血，平肝潜阳，通络止痛之功效，有效用于治疗血虚阳亢证头痛，效果好，疗效高。
Description
技术领域
本发明涉及医药，特别是一种治疗血虚阳亢证头痛的复方中药。
背景技术
血虚阳亢证头痛为常见多发病，中医认为，脑为元神所居,为髓之海,精明之府,其功能的正常发挥有赖于气血的充养和肾精的充盛以及肝气的调畅。年老体弱，思虑过度，影响脾胃运化功能，气血生化乏源，导致气血不足，脑窍失养不荣则痛，阴血亏于下，肝阳亢于上，阳亢化风，上扰清窍而致头痛；或七情内伤，情志不舒，肝失疏泄,肝阳上亢，上扰清窍而致头痛。血虚阳亢证头痛临床表现为：头痛多伴有眩晕眼花，或经久不愈，多见额部疼痛、心烦易怒、失眠多梦、舌红、脉弦细或弦，治则以养血活血，平肝潜阳，通络止痛为主。目前治疗血虚阳亢证头痛的药物有正天丸、养血清脑颗粒，但由于组分和有效成分的用量存在的问题，多是用于治疗阴虚阳亢、血虚、肝阳上亢、偏头痛(血虚阳亢挟瘀型)，对于治疗血虚阳亢证头痛其使用和疗效并不尽人意，因此，治疗血虚阳亢证头痛药物上的改进和创新势在必行。
发明内容
针对上述情况，为克服现有技术之缺陷，本发明之目的就是提供一种治疗血虚阳亢证头痛的复方中药，可有效解决疗效好的治疗血虚阳亢证头痛的用药问题。
本发明解决的技术方案是，一种治疗血虚阳亢证头痛的复方中药，由川芎18-30g、当归12-18g、酸枣仁21-30g、知母18-30g、茯苓15-21g、天麻15-21g、白薇15-21g、白蒺藜6-10g和甘草6-10g作原料药物制成，其中，原料药物混合在一起，加水超过药面2-3厘米，浸泡30分钟，先用大火（武火）煮沸，再用小火（文火）保持沸腾25-30分钟，过滤，得第一次滤液；药渣再加水浸没药面，大火煮沸，再用小火（文火）保持沸腾25-30分钟，过滤，得第二次滤液，合并两次滤液，混匀，即为成品中药液。
本发明原料丰富，组方科学合理，易生产制备，服用方便，具有养血活血，平肝潜阳，通络止痛之功效，有效用于治疗血虚阳亢证头痛，效果好，疗效高，是治疗血虚阳亢证头痛药物上的创新，有显著的经济和社会效益。
具体实施方式
以下结合具体情况和实施例对本发明的具体实施方式作详细说明。
本发明在具体实施中可由以下实施例给出。
实施例1
本发明一种治疗血虚阳亢证头痛的复方中药，由川芎24g、当归15g、酸枣仁25.5g、知母24g、茯苓18g、天麻18g、白薇18g、白蒺藜8g和甘草8g作原料药物制成，其中，原料药物混合在一起，加水超过药面2-3厘米，浸泡30分钟，先用大火（武火）煮沸，再用小火（文火）保持沸腾25-30分钟，过滤，得第一次滤液；药渣再加水浸没药面，大火煮沸，再用小火（文火）保持沸腾25-30分钟，过滤，得第二次滤液，合并两次滤液，混匀，即为成品中药液。
实施例2
本发明一种治疗血虚阳亢证头痛的复方中药，由川芎21g、当归12g、酸枣仁21g、知母18g、茯苓15g、天麻15g、白薇15g、白蒺藜6g和甘草6g作原料药物制成，制备方法同实施例1。
实施例3
本发明一种治疗血虚阳亢证头痛的复方中药，由川芎19g、当归17g、酸枣仁22g、知母29g、茯苓16g、天麻20g、白薇16g、白蒺藜9g和甘草7g作原料药物制成，制备方法同实施例1。
实施例4
本发明一种治疗血虚阳亢证头痛的复方中药，由川芎29g、当归13g、酸枣仁29g、知母19g、茯苓20g、天麻16g、白薇20g、白蒺藜7g和甘草9g作原料药物制成，制备方法同实施例1。
在上述药物中，其中：
川芎：味辛，性温，归肝、胆、心经，活血行气，祛风止痛，可治头风头痛、风湿痹痛等症。
当归：味甘、辛，性温，归肝、心、脾经，具有补血活血，调经止痛，润肠通便之功效。常用于血虚萎黄，眩晕心悸，月经不调，经闭痛经，虚寒腹痛，风湿痹痛，跌扑损伤，痈疽疮疡，肠燥便秘。
酸枣仁：味酸甘，平，微温，入心、脾、肝、胆经，养肝，宁心，安神，敛汗。治虚烦不眠，惊悸怔忡，烦渴，虚汗；
知母：味苦，寒，归肺、胃、肾经。清热泻火，滋阴润燥，治热病烦渴，肺热燥咳，骨蒸潮热，内热消渴，肠燥便秘；
茯苓：味甘、淡，性平，归心、肺、脾、肾经，利水渗湿，健脾，宁心，用于水肿尿少，痰饮眩悸，脾虚食少，便溏泄泻，心神不安，惊悸失眠；
天麻：味甘，性平；归肝经，具有息风止痉，平抑肝阳，祛风通络的功效。主治肝风内动，惊痫抽搐，眩晕，头痛，肢体麻木，手足不遂，风湿痹痛等；
白薇：味苦咸，气温，入肺、胃、肾经，有除虚烦、清热散肿、生肌止痛之效，可治产后虚烦呕逆，小便淋沥，肾炎，尿路感染，水肿，支气管炎和风湿性腰腿痛等；
白蒺藜：味辛、苦，微温，归肝经，有平肝解郁，活血祛风，明目，止痒之效，用于头痛眩晕，胸胁胀痛，乳闭乳痈，目赤翳障，风疹瘙痒；
甘草：味甘，性平，归心经、肺经、脾经、胃经；益气补中、清热解毒、祛痰止咳、缓急止痛、调和药性；主治：脾气虚弱，倦怠乏力，心悸气短，咳嗽痰多，脘腹、四肢挛急疼痛，热毒疮疡，咽喉肿痛，药物、食物中毒；缓和药物烈性、毒性。
由上述药物可知，川芎活血行气、祛风止痛，是治疗头痛的要药；当归补血活血,兼能散寒,故善治血虚、血瘀、血寒诸痛，川芎、当归合用，养血活血、行气止痛。天麻平肝潜阳，祛风止痛，适用于偏正头痛；白薇凉血益阴、退热除蒸；白蒺藜平抑肝阳，散风明目，二者合用有清热平肝、凉血行血、疏风明目之功效。健脾养血，清热除烦之功效。甘草益气补中，缓急止痛，调和诸药。诸药合用，有养血活血，平肝潜阳，通络止痛之功。有效用于治疗血虚阳亢证头痛，并经临床试验取得了非常好的有益技术效果，有关试验资料如下：
1 中医选择病例的标准：年龄在 18～60岁；血虚阳亢证头痛：头痛多伴有眩晕眼花,或经久不愈,多见额部疼痛，心烦易怒，失眠多梦，舌红，脉弦细或弦，凡具有上述症状，均纳入中医选择病例的标准。
2 诊断标准
凡具有上述1症状者，并患有头痛症状者，均可确诊为血虚阳亢证头痛，并给予本发明中药治疗。
3 治疗方案
给予本发明实施例1汤药口服，每日两次，早晚各1次，每次200-300mL，连续14天为一疗程。治疗期间忌浓茶、咖啡、辛辣刺激食物。治疗14天后观察统计疗效。
4 疗效判定标准 参考文献拟定，见国家中医药管理局.中医病证诊断疗效标准[S].南京:南京大学出版社, 1994.22～23。
治愈:症状头痛消失。好转:症状头痛减轻,发作时间缩短或周期延长。无效:症状头痛无变化，甚而有加重之趋势。
5 统计学处理
根据诊断标准，对确诊的自2017年1月至2019年12月河南省中医院脑病科门诊患者50例。其中男性18例，女性32例；年龄19-58岁，平均年龄32.1±7.8岁；病程3个月～6年，平均病程 2.6±1.6年。经统计学处理，50例患者治疗14天后治愈24例，占48%，好转25例，占50%；无效1例，占2%，总有效率98%。
在对实施例1试用的同时，还对其他实施例做了同要的试验，均取得了相同和相近似的结果，这里不一一列举，试验表明，药物疗效稳定、可靠，在试验中未发现有任何不良反应，表明用药安全。
结论
中医学认为,脑为元神所居,为髓之海,精明之府,其功能的正常发挥有赖于气血的充养和肾精的充盛以及肝气的调畅（参见张伯礼，吴勉华.中医内科学[M].北京：中国中医药出版社，2017）。年老体弱，思虑过度，影响脾胃运化功能，气血生化乏源，导致气血不足，脑窍失养不荣则痛，阴血亏于下，肝阳亢于上，阳亢化风，上扰清窍而致头痛；或七情内伤，情志不舒，肝失疏泄,肝阳上亢，上扰清窍而致头痛。治则以养血活血，平肝潜阳，通络止痛为主。
在本发明组合物中，川芎、当归为君药，川芎活血行气、祛风止痛，是治疗头痛的要药；当归补血活血,兼能散寒,故善治血虚、血瘀、血寒诸痛，川芎、当归合用，养血活血、行气止痛。天麻、白薇、白蒺藜为臣药，天麻平肝潜阳，祛风止痛，适用于偏正头痛；白薇凉血益阴、退热除蒸；白蒺藜平抑肝阳，散风明目，二者合用有清热平肝、凉血行血、疏风明目之功效。酸枣仁、知母、茯苓为佐药，健脾养血，清热除烦之功效。甘草为使药，益气补中，缓急止痛，调和诸药。诸药合用，有养血活血，平肝潜阳，通络止痛之功，有效用于治疗血虚阳亢证头痛。
通过治血虚阳亢证头痛的临床试验，得出以下结论：血虚阳亢，经络不通为血虚阳亢头痛的主要病机。养血活血，平肝潜阳，通络止痛为血虚阳亢头痛的基本治疗方法。本发明给出的复方中药，正好用于治疗血虚阳亢证头痛，疗效稳定可靠，疗效高达98%，用药安全，原料丰富，易生产制备，开拓了治疗血虚阳亢证头痛药物的新途径，是治疗血虚阳亢证头痛药物上的创新，有显著的经济和社会效益。
由上述可以清楚的看出，本发明请求保护的核心在于中药组合物及其用量，因此，凡是根据本发明给出的中药组合物及其用量按常规方法制备成的各种适于医学上使用（服用）的剂型，如颗粒剂、丸剂、胶囊剂、片剂等，均属于本发明的保护范围。
Claims (6)
1.一种治疗血虚阳亢证头痛的复方中药，其特征在于，由川芎18-30g、当归12-18g、酸枣仁21-30g、知母18-30g、茯苓15-21g、天麻15-21g、白薇15-21g、白蒺藜6-10g和甘草6-10g作原料药物制成，其中，原料药物混合在一起，加水超过药面2-3厘米，浸泡30分钟，先用大火煮沸，再用小火保持沸腾25-30分钟，过滤，得第一次滤液；药渣再加水浸没药面，大火煮沸，再用小火保持沸腾25-30分钟，过滤，得第二次滤液，合并两次滤液，混匀，即为成品中药液。
2.根据权利要求1所述的治疗血虚阳亢证头痛的复方中药，其特征在于，由川芎24g、当归15g、酸枣仁25.5g、知母24g、茯苓18g、天麻18g、白薇18g、白蒺藜8g和甘草8g作原料药物制成。
3.根据权利要求1所述的治疗血虚阳亢证头痛的复方中药，其特征在于，由川芎21g、当归12g、酸枣仁21g、知母18g、茯苓15g、天麻15g、白薇15g、白蒺藜6g和甘草6g作原料药物制成。
4.根据权利要求1所述的治疗血虚阳亢证头痛的复方中药，其特征在于，由川芎19g、当归17g、酸枣仁22g、知母29g、茯苓16g、天麻20g、白薇16g、白蒺藜9g和甘草7g作原料药物制成。
5.根据权利要求1所述的治疗血虚阳亢证头痛的复方中药，其特征在于，由川芎29g、当归13g、酸枣仁29g、知母19g、茯苓20g、天麻16g、白薇20g、白蒺藜7g和甘草9g作原料药物制成。
6.权利要求1-5所述的治疗血虚阳亢证头痛的复方中药，为汤剂、颗粒剂、丸剂、胶囊剂或片剂。
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