CN111544500A - Traditional Chinese medicine composition for assisting blood pressure reduction and external preparation and application thereof - Google Patents
Traditional Chinese medicine composition for assisting blood pressure reduction and external preparation and application thereof Download PDFInfo
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The invention provides a traditional Chinese medicine composition for assisting blood pressure reduction, an external preparation and application thereof, wherein active components of the traditional Chinese medicine composition comprise the following raw material medicines in parts by weight: 8-15 parts of chrysanthemum, 8-15 parts of albizia flower, 5-12 parts of folium artemisiae argyi, 5-12 parts of honeysuckle leaves, 8-18 parts of semen cassiae, 8-13 parts of selfheal, 5-12 parts of folium mori and 8-15 parts of rhizoma acori graminei. In the formula of the invention, the chrysanthemum is used for calming the liver and reducing blood pressure, clearing heat and improving eyesight, and the cassia seed is used for clearing liver and improving eyesight and reducing blood pressure, and is a monarch drug together; the flos albiziae has the effects of regulating qi, resolving stagnation, calming nerves, removing liver heat from the selfheal, improving eyesight, dissipating stagnation and reducing swelling, and is used as a ministerial drug; rhizoma acori graminei opens orifices and clears phlegm, refreshes mind and benefits intelligence, honeysuckle leaves and mulberry leaves clear heat and calm liver, folium artemisiae argyi warms channel and dispels cold to monitor various medicines, and the medicines are used as adjuvant medicines together; has the effects of refreshing and relieving, calming the liver and reducing blood pressure, effectively assists in reducing blood pressure and reducing blood pressure fluctuation, and provides an effective auxiliary external medicament for patients with hypertension.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for assisting blood pressure reduction, an external preparation and application thereof.
Background
Hypertension (hypertension) is a clinical syndrome characterized by an increase in systemic arterial blood pressure (systolic pressure and/or diastolic pressure) (systolic pressure not less than 140 mm hg, diastolic pressure not less than 90mm hg), which may be accompanied by functional or organic damage to organs such as heart, brain, kidney, etc. Hypertension is one of the most common chronic diseases, and requires long-term adherence to taking hypotensive drugs. On the basis of taking the conventional antihypertensive drug, the blood pressure of some patients obviously fluctuates outside the normal range, so that certain potential safety hazards exist. The traditional Chinese medicine sachet can be worn on person and can be absorbed through respiratory tract or skin to exert the function. However, the traditional Chinese medicine sachet has poor effect of assisting blood pressure reduction, and the invention aims to provide a traditional Chinese medicine composition which is prepared into a traditional Chinese medicine external preparation sachet and the like to obviously improve the fluctuation symptom of blood pressure.
Disclosure of Invention
In view of the above, the invention provides a traditional Chinese medicine composition for assisting blood pressure reduction, an external preparation and application thereof.
The technical scheme of the invention is realized as follows: the traditional Chinese medicine composition for assisting blood pressure reduction comprises the following active components in parts by weight: 8-15 parts of chrysanthemum, 8-15 parts of albizia flower, 5-12 parts of folium artemisiae argyi, 5-12 parts of honeysuckle leaves, 8-18 parts of semen cassiae, 8-13 parts of selfheal, 5-12 parts of folium mori and 8-15 parts of rhizoma acori graminei.
Preferably, the active components of the traditional Chinese medicine composition comprise the following raw material medicines in parts by weight: 14 parts of chrysanthemum, 13 parts of albizia flower, 8 parts of folium artemisiae argyi, 10 parts of honeysuckle flower leaf, 15 parts of semen cassiae, 13 parts of selfheal, 8 parts of mulberry leaf and 12 parts of rhizoma acori graminei.
Preferably, the chrysanthemum is white chrysanthemum.
A traditional Chinese medicine composition external preparation for assisting blood pressure reduction comprises any one of the traditional Chinese medicine compositions for assisting blood pressure reduction. Preferably, the external preparation of the traditional Chinese medicine composition is one of sachet and pill.
The traditional Chinese medicine composition disclosed by the invention is applied to preparation of a medicine for assisting blood pressure reduction.
Compared with the prior art, the invention has the beneficial effects that: in the formula of the invention, the chrysanthemum is used for calming the liver and reducing blood pressure, clearing heat and improving eyesight, and the cassia seed is used for clearing liver and improving eyesight and reducing blood pressure, and is a monarch drug together; the flos albiziae has the effects of regulating qi, resolving stagnation, calming nerves, removing liver heat from the selfheal, improving eyesight, dissipating stagnation and reducing swelling, and is used as a ministerial drug; rhizoma acori graminei opens orifices and clears phlegm, refreshes mind and benefits intelligence, honeysuckle leaves and mulberry leaves clear heat and calm liver, folium artemisiae argyi warms channel and dispels cold to monitor various medicines, and the medicines are used as adjuvant medicines together; has the effects of refreshing and relieving, calming the liver and reducing blood pressure, effectively assists in reducing blood pressure and reducing blood pressure fluctuation, and provides an effective auxiliary external medicament for patients with hypertension.
Detailed Description
In order to better understand the technical content of the invention, specific examples are provided below to further illustrate the invention.
The experimental methods used in the examples of the present invention are all conventional methods unless otherwise specified.
The materials, reagents and the like used in the examples of the present invention can be obtained commercially without specific description.
The basic conditions of the main raw materials are described in the following according to Chinese pharmacopoeia, Chinese dictionary, Chinese herbage and Shanghai Chinese medicinal material standards (1994 version).
Bai Ju Hua (character and taste) is sweet, bitter and slightly cold. [ GUIJING ] enters lung and liver meridians. [ FUNCTIONS ] can dispel pathogenic wind, clear away heat, calm the liver, and improve eyesight. Can be used for treating wind-heat type common cold, headache, giddiness, conjunctival congestion, swelling and pain, and blurred vision.
Albizzia flower: [ PROPERTIES AND FLAVOUR ] sweet and neutral. [ GUIJING ] returning to the heart and liver meridians. [ FUNCTIONS ] can relieve depression and tranquilize mind. Can be used for treating uneasiness, depression and insomnia.
Cassia seed: [ PROPERTIES AND WESTERN PROPERTIES ] is sweet, bitter, salty and slightly cold. [ GUIJING ] enters liver and large intestine meridians. [ FUNCTIONS ] can clear away heat, improve eyesight, moisten intestines and relieve constipation. Can be used for treating conjunctival congestion, photophobia, lacrimation, headache, vertigo, dim eyesight, and constipation.
Selfheal: [ PROPERTIES AND FLAVOURS ] pungent, bitter and cold in flavor. [ GUIJING ] enters liver and gallbladder meridians. [ FUNCTIONS ] can clear away pathogenic fire, improve eyesight, dissipate stagnation, and relieve swelling. Can be used for treating conjunctival congestion, swelling and pain, eyeball nyctalgia, headache, giddiness, scrofula, goiter, mammary abscess, and swelling and pain; goiter, tuberculous lymphadenitis, hyperplasia of mammary glands, and hypertension.
Rhizoma Acori Graminei (character and taste) is pungent, bitter and slightly warm. [ GUIJING ] can be attributed to heart, liver and spleen meridians. [ FUNCTIONS ] can resolve phlegm, induce resuscitation, remove dampness, promote the circulation of qi, dispel wind, relieve arthralgia, dissipate stagnation and alleviate pain. Can be used for treating fever unconsciousness, phlegm syncope, abdominal distention and pain, rheumatalgia, phlegm obstruction of heart, improving blood rheological property, resisting thrombosis, and resisting myocardial ischemia.
Folium artemisiae argyi: [ PROPERTIES AND WESTERN PROPERTIES ] is pungent, bitter and warm; has little toxicity. [ GUIJING ] enters liver, spleen and kidney meridians. [ FUNCTIONS ] can dispel cold, alleviate pain, warm meridians and stop bleeding. Can be used for treating lower abdomen psychroalgia, irregular menstruation, infertility due to cold womb, hematemesis, epistaxis, metrorrhagia, metrostaxis, and pregnancy bleeding; it can be used for treating skin pruritus.
Honeysuckle flower leaf: [ PROPERTIES AND FLAVOUR GUIDING JING ] is sweet and cold. [ GUIJING ] GUIJING is responsible for heart and lung meridians. [ FUNCTIONS ] can clear away heat and toxic materials. It is mainly used for treating pyrexia, dysentery with bloody stool due to heat-toxicity, infectious hepatitis, sore, carbuncle, swelling, etc.
Mulberry leaf: [ PROPERTIES AND FLAVOURS ] sweet, bitter and cold. [ GUIJING ] enters lung and liver meridians. [ FUNCTIONS ] can dispel wind-heat, clear lung-heat, moisten dryness, clear liver-heat and improve eyesight. Can be used for treating wind-heat type common cold, lung heat type cough, dizziness, headache, conjunctival congestion, and dim eyesight.
Example 1
A traditional Chinese medicine composition for assisting blood pressure reduction is composed of the following raw material medicines in parts by weight: 10 parts of white chrysanthemum, 10 parts of albizia flower, 10 parts of folium artemisiae argyi, 10 parts of honeysuckle flower leaf, 10 parts of semen cassiae, 10 parts of selfheal, 10 parts of mulberry leaf and 10 parts of rhizoma acori graminei. Pulverizing the above materials, and packaging into sachet medicinal bag to obtain traditional Chinese medicine sachet.
Example 2
A traditional Chinese medicine composition for assisting blood pressure reduction is composed of the following raw material medicines in parts by weight: 8 parts of white chrysanthemum, 15 parts of albizia flower, 12 parts of folium artemisiae argyi, 5 parts of honeysuckle flower leaf, 18 parts of semen cassiae, 8 parts of selfheal, 5 parts of mulberry leaf and 15 parts of rhizoma acori graminei. Pulverizing the above materials, and packaging into sachet medicinal bag to obtain traditional Chinese medicine sachet.
Example 3
A traditional Chinese medicine composition for assisting blood pressure reduction is composed of the following raw material medicines in parts by weight: 15 parts of white chrysanthemum, 8 parts of albizia flower, 5 parts of folium artemisiae argyi, 12 parts of honeysuckle flower leaf, 8 parts of semen cassiae, 13 parts of selfheal, 12 parts of mulberry leaf and 8 parts of rhizoma acori graminei. Pulverizing the above materials, and packaging into sachet medicinal bag to obtain traditional Chinese medicine sachet.
Example 4
A traditional Chinese medicine composition for assisting blood pressure reduction is composed of the following raw material medicines in parts by weight: 14 parts of white chrysanthemum, 13 parts of albizia flower, 8 parts of folium artemisiae argyi, 10 parts of honeysuckle flower leaf, 15 parts of semen cassiae, 13 parts of selfheal, 8 parts of mulberry leaf and 12 parts of rhizoma acori graminei. Pulverizing the above materials, and packaging into sachet medicinal bag to obtain traditional Chinese medicine sachet.
Comparative example 1
A traditional Chinese medicine composition is composed of the following raw material medicines in parts by weight: 20 parts of white chrysanthemum, 5 parts of albizia flower, 15 parts of folium artemisiae argyi, 15 parts of honeysuckle flower leaf, 5 parts of semen cassiae, 5 parts of selfheal, 15 parts of mulberry leaf and 5 parts of rhizoma acori graminei. Pulverizing the above materials, and packaging into sachet medicinal bag to obtain traditional Chinese medicine sachet.
Comparative example 2
A traditional Chinese medicine composition, which is different from the embodiment 4 in that albizia flower is replaced by the same amount of white chrysanthemum, and grassleaf sweelflag rhizome is replaced by the same amount of selfheal.
The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 27 parts of white chrysanthemum, 8 parts of folium artemisiae argyi, 10 parts of honeysuckle leaves, 15 parts of semen cassiae, 25 parts of selfheal and 8 parts of mulberry leaves. Pulverizing the above materials, and packaging into sachet medicinal bag to obtain traditional Chinese medicine sachet.
The traditional Chinese medicine sachet prepared by the method is applied to clinic:
1. basic data: 300 patients with hypertension are collected, and the patients have obvious fluctuation of blood pressure outside the normal range value on the basis of taking conventional antihypertensive drugs, the fluctuation range of systolic pressure is 140-160mmHg, and the fluctuation range of diastolic pressure is 90-100 mmHg. The age is 40-70 years old; the groups were randomly divided into test group 1 to test group 6, and each group had 50 cases. The gender distribution, mean age for each group are shown in the following table:
2. the application method and the treatment course are as follows: on the basis of taking conventional antihypertensive drugs, the traditional Chinese medicine sachets of examples 1-4 and comparative examples 1-2 are respectively used in test groups 1-6 of hypertension patients, and each sachet contains about 25 g of traditional Chinese medicine. The using method comprises the following steps: each person wears 1 sachet per day, smells before nose for 3-4 times every day, each time for 2-3 minutes, and puts on the edge of pillow when sleeping. The sachet was changed 1 time every 7 days and was used continuously for 3 months. If the water is affected with damp, the water is replaced in time.
3. Criteria for judging therapeutic effects
The effect is shown: the blood pressure is basically stable, and the measured blood pressure does not exceed the normal value;
the method has the following advantages: the blood pressure fluctuation amplitude is reduced to some extent, but the measured blood pressure still exceeds a normal value;
and (4) invalidation: there was no improvement.
4. Therapeutic results
The clinical conditions show that the traditional Chinese medicine composition has a remarkable treatment effect on auxiliary hypertension, the significant efficiency is more than 76.0%, and the total effective rate is more than 98.0%.
5. Typical cases
Medical record 1: wangzhi, male, 58 years old, and more than 5 years old in hypertension history, the antihypertensive drug is orally taken for a long time to control the blood pressure, but the blood pressure fluctuation is obvious, the traditional Chinese medicine sachet in embodiment 4 of the invention is carried along when the antihypertensive drug is orally taken at the same time of 158mmHg/92-96mmHg at 140-; the sachet was replaced 1 time every 7 days. After 3 months of using the sachet, the blood pressure is basically stable, the measured blood pressure does not exceed the normal value, and the blood pressure is basically maintained at 132-136mmHg/80-86 mmHg.
Medical record 2: in recent years, the blood pressure fluctuation of a woman is measured to be 146mmHg/86-94mmHg in the age of 40, and the woman is not treated by an oral hypotensor, and the traditional Chinese medicine sachet in the embodiment 1 of the invention is carried with the woman, smells 3-4 times before the nose every day, and each time lasts for 2-3 minutes, and is placed at the edge of a pillow when sleeping; the sachet was replaced 1 time every 7 days. After 2 months, the blood pressure fluctuation is between 130 and 144mmHg/82-92mmHg, and after 1 month of continuously using the sachet, the blood pressure fluctuation is between 128 and 136mmHg/80-90 mmHg.
6. And (4) safety observation: in all cases observed, no adverse reactions were observed.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (6)
1. The traditional Chinese medicine composition for assisting blood pressure reduction is characterized in that active components of the traditional Chinese medicine composition comprise the following raw material medicines in parts by weight: 8-15 parts of chrysanthemum, 8-15 parts of albizia flower, 5-12 parts of folium artemisiae argyi, 5-12 parts of honeysuckle leaves, 8-18 parts of semen cassiae, 8-13 parts of selfheal, 5-12 parts of folium mori and 8-15 parts of rhizoma acori graminei.
2. The traditional Chinese medicine composition for assisting blood pressure reduction according to claim 1, which is characterized in that the active ingredients comprise the following raw material medicines in parts by weight: 14 parts of chrysanthemum, 13 parts of albizia flower, 8 parts of folium artemisiae argyi, 10 parts of honeysuckle flower leaf, 15 parts of semen cassiae, 13 parts of selfheal, 8 parts of mulberry leaf and 12 parts of rhizoma acori graminei.
3. The traditional Chinese medicine composition for assisting blood pressure reduction according to claim 1, wherein the chrysanthemum is white chrysanthemum.
4. An external preparation of a traditional Chinese medicine composition for assisting blood pressure reduction, which is characterized by comprising the traditional Chinese medicine composition for assisting blood pressure reduction of any one of claims 1 to 3.
5. The external traditional Chinese medicine composition preparation for assisting blood pressure reduction according to claim 4, wherein the external traditional Chinese medicine composition preparation is one of sachet and pill.
6. The use of the Chinese medicinal composition of any one of claims 1 to 5 in the preparation of a medicament for assisting in lowering blood pressure.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103006783A (en) * | 2012-11-21 | 2013-04-03 | 徐曼丽 | Traditional Chinese medicine scented sachet for lowering blood pressure |
| CN103599284A (en) * | 2013-12-01 | 2014-02-26 | 卡玛力亚·努尔加吾 | Kazakhstan traditional pharmaceutical composition for treating hypertension and preparation method thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103006783A (en) * | 2012-11-21 | 2013-04-03 | 徐曼丽 | Traditional Chinese medicine scented sachet for lowering blood pressure |
| CN103599284A (en) * | 2013-12-01 | 2014-02-26 | 卡玛力亚·努尔加吾 | Kazakhstan traditional pharmaceutical composition for treating hypertension and preparation method thereof |
Non-Patent Citations (3)
| Title |
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| 何迎春: "开窍醒神——石菖蒲", 《HTTP://WWW.YDZZ.COM/JKSQ.PHP?COL=41&FILE=22108》 * |
| 吴林玲: "《高血压饮食+运动+中医调养全书》", 31 July 2016, 天津科学技术出版社 * |
| 范正祥: "《常见病简易疗法手册》", 31 December 1988, 人民卫生出版社 * |
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