CN111529673A - Traditional Chinese medicine composition for treating beriberi and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating beriberi and preparation method thereof Download PDFInfo
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The traditional Chinese medicine composition for treating dermatophytosis and the preparation method thereof comprise main materials and auxiliary materials, wherein the main material formula comprises the following components: 50-70 parts of folium artemisiae argyi, 25-40 parts of ginger, 20-35 parts of pepper, 10-35 parts of dried orange peel and 15-35 parts of eucommia bark; the auxiliary material formula is as follows: 50-80 parts of alum and 30-60 parts of acetic acid, and the invention has the beneficial effects that: the traditional Chinese medicine composition for treating beriberi has the advantages of prevention and treatment of infection diseases caused by fungi, good curative effect, low compliance, moderate price, small side effect, difficult recurrence and relatively short treatment course, can be used for treating beriberi caused by fungi, particularly erosive beriberi, enables patients to get rid of beriberi disturbance, and is beneficial to physical and psychological health of the patients.
Description
The technical field is as follows:
the invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating dermatophytosis and a preparation method thereof.
Background art:
beriberi, particularly erosive beriberi, is caused by dermatophytes, i.e., fungi or molds; the disease can be induced by sweaty and damp feet or the air impermeability of shoes and socks; erosive beriberi is the most common of all beriberi types, and is preferably developed between the third and fourth toes and between the fourth and fifth toes; at the beginning, the toes are wet, soaked and whitened, and after being dried and desquamated, the skin is peeled off to form wet and flush erosion faces or accompanied cracks, which are extremely itchy and easy to cause secondary infection. Pathogenic bacteria of this type of tinea pedis are particularly apt to grow and multiply in a humid and warm environment; therefore, when the skin is parasitized between toes with hyperhidrosis for a long time, the epidermis is easy to chap and becomes white due to wet impregnation; it is common for people with sweaty feet or wearing rain shoes and rubber shoes with poor air permeability, and the cutin has excessive water storage and is soaked and whitened.
At present, two ways are mainly used for improving diseases, firstly, light diet is recommended to avoid eating spicy, uncooked, cold and greasy food; secondly, the itraconazole capsule and the bitter ginseng tablet can be orally taken, and are matched with external pedicure dispersion foot soaking, pimpinella pallida ointment or topical application of Dakening emulsifiable paste, the symptoms of about half a month generally can be improved to a certain extent, the curative effect is poor, the effect is not ideal, and great psychological and physical damage is brought to patients.
At present, a medicine for effectively treating beriberi, particularly erosive beriberi, is urgently needed, and can effectively relieve the pain of a patient and eliminate the psychological and physical injuries of the patient.
The invention content is as follows:
the invention aims to provide a traditional Chinese medicine composition for treating dermatophytosis and a preparation method thereof, which can effectively treat dermatophytosis, particularly erosive dermatophytosis, effectively relieve the pain of patients and eliminate the psychological and physical injuries of the patients.
In order to solve the problems, the specific technical scheme of the invention is as follows:
the traditional Chinese medicine composition for treating beriberi comprises main materials and auxiliary materials, wherein the main materials comprise the following components in formula: 50-70 parts of folium artemisiae argyi, 25-40 parts of ginger, 20-35 parts of pepper, 10-35 parts of dried orange peel and 15-35 parts of eucommia bark; the auxiliary material formula is as follows: 50-80 parts of alum and 30-60 parts of acetic acid.
Preferably, the traditional Chinese medicine composition for treating beriberi comprises main materials and auxiliary materials, wherein the main materials comprise the following components in formula: 60 parts of folium artemisiae argyi, 30 parts of ginger, 30 parts of pepper, 25 parts of dried orange peel and 25 parts of eucommia bark; the auxiliary material formula is as follows: 60 parts of alum and 40 parts of acetic acid.
More preferably, the traditional Chinese medicine composition for treating beriberi comprises main materials and auxiliary materials, wherein the main materials comprise the following formula: 50 parts of folium artemisiae argyi, 25 parts of ginger, 20 parts of pepper, 10 parts of dried orange peel and 15 parts of eucommia bark; the auxiliary material formula is as follows: 50 parts of alum and 30 parts of acetic acid.
More preferably, the traditional Chinese medicine composition for treating beriberi comprises main materials and auxiliary materials, wherein the main materials comprise the following formula: 70 parts of folium artemisiae argyi, 40 parts of ginger, 35 parts of pepper, 35 parts of dried orange peel and 35 parts of eucommia bark; the auxiliary material formula is as follows: 80 parts of alum and 60 parts of acetic acid.
The folium Artemisiae Argyi is dried leaf of Artemisia argyi of Compositae. Picking when flos Rosae chinensis is not blooming, removing impurities, and sun drying, and can be used for treating hematemesis, epistaxis, metrorrhagia, menorrhagia, vaginal bleeding due to fetal leakage, lower abdomen psychroalgia, menoxenia, and infertility due to cold womb; it can be used for treating skin pruritus. Vinegar moxa charcoal can warm meridians and stop bleeding, and is indicated for bleeding due to deficiency-cold.
The ginger is a perennial herb of Zingiber of family Zingiberaceae. Rhizome with yellow-green flower and pungent flavor. The plant height is 0.5-1 m; the rhizome is thick, multi-branched, fragrant and pungent. The leaves are in a needle shape or a linear needle shape, and have no hair and handle; lamina linguistics. The total peduncle length is up to 25 cm; the panicle-shaped inflorescence is cone-shaped; the bract is oval, light green or yellowish in edge, and has a small tip at the top. Calyx tube about 1 cm long; the corolla is yellow green, and the splinters are needle-shaped; the central fissure of the labial flap is in the shape of a long circle and an inverted oval. Ginger, rhizoma Zingiberis recens, with pungent and slightly warm nature, enters spleen, stomach and lung meridians. Has effects in inducing sweat, relieving exterior syndrome, warming middle warmer, relieving vomit, warming lung, relieving cough, and removing toxic materials. Can be used for treating wind-cold type common cold, emesis due to stomach cold, cough due to wind-cold type common cold, abdominal pain, diarrhea, fish and crab toxin. Also has effects of activating stomach, promoting spleen function, and stimulating appetite.
The fructus Zanthoxyli is Rutaceae, Laxylum deciduous tree, and has height of 7 m; short thorns exist on the branches of the stems, and the branches growing in the current year are short and soft. The blade shaft is often provided with very narrow blade wings; the lobules are opposite, oval, elliptical and thin in needle shape, the leaf margin has fine fissures, and the tooth gaps have oil spots. The leaf back is velvety and the leaf back is dry with reddish-brown patches. The inflorescence grows from the top of the lateral branch or grows from the top of the lateral branch, the perianth sheet is yellow green, and the shape and the size are approximately the same; the flower pillar bends back obliquely. Purple red fruit, scattered micro-convex oil spots, 4-5 months of flowering period, 8-9 months or 10 months of fruit period. Has effects in warming middle energizer, activating qi-flowing, expelling cold, relieving pain, and killing parasite. It can be used for treating stomach and abdominal psychroalgia, emesis, diarrhea, schistosomiasis, and ascariasis. Also used as an epidermal anesthetic.
The pericarpium Citri Tangerinae is dried mature pericarp of Rutaceae plant fructus Citri Tangerinae and its cultivar. The medicinal materials are classified into pericarpium citri reticulatae and pericarpium citri reticulatae. Picking mature fruit, peeling peel, and drying in the sun or at low temperature. Can be used for treating abdominal distention, anorexia, vomiting, diarrhea, cough, and excessive phlegm.
The eucommia ulmoides is medicinal eucommia ulmoides, namely dried bark of eucommia ulmoides of family eucommia ulmoides, and is a famous and precious Chinese medicinal material. It is sweet in taste and warm in nature. Has effects in tonifying liver and kidney, strengthening muscle and bone, regulating Chong and ren meridians, and preventing miscarriage. Can be used for treating lumbago, leg pain, soreness, weakness, and infertility due to kidney-yang deficiency, and damp and itching scrotum due to liver-qi deficiency. It is listed as the superior in Shen nong Ben Cao Jing.
The alum is a mineral Chinese medicine. The external use can detoxify, kill parasites, eliminate dampness and relieve itching; internal use can stop bleeding, check diarrhea and resolve phlegm. The main treatment is as follows: stroke; epilepsy; pharyngitis; scabies, tinea and eczema; abscess, deep-rooted carbuncle and pyogenic infections; scald by hot water or fire; sores in the mouth and tongue; rotten wind eyes; purulent ear; polyps in the nose; sore and hemorrhoid pain; (ii) metrorrhagia and metrostaxis; bleeding; bleeding from injury; chronic diarrhea and dysentery; itching vaginal discharge; rectocele; uterine prolapse. Alumen is sour and astringent in taste, cold and toxic. Therefore, it has antibacterial and astringent effects, and can be used as Chinese medicinal material.
The acetic acid is organic monoacid and is the main component of the vinegar, the content of the acetic acid is 36-38%, the chemical formula is CH3COOH, and pure anhydrous acetic acid, namely glacial acetic acid is colorless hygroscopic solid, the freezing point is 16.6 ℃, the acetic acid is colorless crystals after solidification, the aqueous solution of the acetic acid is weakly acidic and has strong corrosivity, and steam has irritation on eyes and nose.
In order to achieve the purpose, the invention adopts the following scheme that the preparation method of the traditional Chinese medicine composition for treating beriberi comprises the following steps:
step one, preparing main materials
1) Taking 50-70 parts of folium artemisiae argyi, 25-40 parts of ginger, 20-35 parts of pepper, 10-35 parts of dried orange peel and 15-35 parts of eucommia ulmoides; respectively putting into a wall breaking machine for wall breaking and crushing, controlling the rotating speed at 28000 r/min, and then putting into a stirrer together for fully stirring to obtain a mixture;
2) adding the mixture into purified water 2 times the weight of the mixture, and fully soaking for 24-48 hours at the temperature of 20-25 ℃ to obtain a mixture soaking solution;
3) putting the mixture soak solution into a distillation pot, and then heating and distilling the mixture soak solution at the temperature of 100-110 ℃ to prepare a main material solution;
step two, preparing auxiliary materials
1) Taking 50-80 parts by weight of alum and 30-60 parts by weight of acetic acid; adding the mixture into a stirring kettle, and stirring to obtain a stirring solution;
2) adding the stirred solution into a distillation pot, and then heating and distilling, wherein the temperature is controlled to be between 100 and 110 ℃ to prepare an auxiliary material liquid;
step three, mixing the main feed liquid and the auxiliary material liquid according to the ratio of 1: 1 part by weight of the raw materials are fully mixed to prepare the traditional Chinese medicine composition for treating beriberi.
The invention has the beneficial effects that: the traditional Chinese medicine composition for treating beriberi has the advantages of prevention and treatment of infection diseases caused by fungi, good curative effect, low compliance, moderate price, small side effect, difficult recurrence and relatively short treatment course, can be used for treating beriberi caused by fungi, particularly erosive beriberi, enables patients to get rid of beriberi disturbance, and is beneficial to physical and psychological health of the patients.
Detailed Description
The invention will now be further described with reference to specific examples in order that the public may better understand the manner in which the invention is carried out.
The examples are given for the purpose of illustration and are not to be construed as limiting the invention, so that those skilled in the art may make insubstantial modifications and adaptations of the embodiments based on the above teachings and still fall within the scope of the invention.
In the case of the example 1, the following examples are given,
the traditional Chinese medicine composition for treating beriberi comprises main materials and auxiliary materials, wherein the main materials comprise the following components in formula: 50-70 parts of folium artemisiae argyi, 25-40 parts of ginger, 20-35 parts of pepper, 10-35 parts of dried orange peel and 15-35 parts of eucommia bark; the auxiliary material formula is as follows: 50-80 parts of alum and 30-60 parts of acetic acid.
The preparation method of the traditional Chinese medicine composition for treating beriberi comprises the following steps:
step one, preparing main materials
1) Taking 50-70 parts of folium artemisiae argyi, 25-40 parts of ginger, 20-35 parts of pepper, 10-35 parts of dried orange peel and 15-35 parts of eucommia ulmoides; respectively putting into a wall breaking machine for wall breaking and crushing, controlling the rotating speed at 28000 r/min, and then putting into a stirrer together for fully stirring to obtain a mixture;
2) adding the mixture into purified water 2 times the weight of the mixture, and fully soaking for 24-48 hours at the temperature of 20-25 ℃ to obtain a mixture soaking solution;
3) putting the mixture soak solution into a distillation pot, and then heating and distilling the mixture soak solution at the temperature of 100-110 ℃ to prepare a main material solution;
step two, preparing auxiliary materials
1) Taking 50-80 parts by weight of alum and 30-60 parts by weight of acetic acid; adding the mixture into a stirring kettle, and stirring to obtain a stirring solution;
2) adding the stirred solution into a distillation pot, and then heating and distilling, wherein the temperature is controlled to be between 100 and 110 ℃ to prepare an auxiliary material liquid;
step three, mixing the main feed liquid and the auxiliary material liquid according to the ratio of 1: 1 part by weight of the raw materials are fully mixed to prepare the traditional Chinese medicine composition for treating beriberi.
In the case of the example 2, the following examples are given,
the traditional Chinese medicine composition for treating beriberi comprises main materials and auxiliary materials, wherein the main materials comprise the following components in formula: 60 parts of folium artemisiae argyi, 30 parts of ginger, 30 parts of pepper, 25 parts of dried orange peel and 25 parts of eucommia bark; the auxiliary material formula is as follows: 60 parts of alum and 40 parts of acetic acid.
The preparation method of the traditional Chinese medicine composition for treating beriberi comprises the following steps:
step one, preparing main materials
1) Taking 60 parts by weight of folium artemisiae argyi, 30 parts by weight of ginger, 30 parts by weight of pepper, 25 parts by weight of dried orange peel and 25 parts by weight of eucommia ulmoides; respectively putting into a wall breaking machine for wall breaking and crushing, controlling the rotating speed at 28000 r/min, and then putting into a stirrer together for fully stirring to obtain a mixture;
2) adding the mixture into purified water 2 times the weight of the mixture, and fully soaking for 24 hours at the temperature of 20-25 ℃ to obtain a mixture soaking solution;
3) putting the mixture soak solution into a distillation pot, and then heating and distilling the mixture soak solution at the temperature of 100-110 ℃ to prepare a main material solution;
step two, preparing auxiliary materials
1) Taking 60 parts by weight of alum and 40 parts by weight of acetic acid; adding the mixture into a stirring kettle, and stirring to obtain a stirring solution;
2) adding the stirred solution into a distillation pot, and then heating and distilling, wherein the temperature is controlled to be between 100 and 110 ℃ to prepare an auxiliary material liquid;
step three, mixing the main feed liquid and the auxiliary material liquid according to the ratio of 1: 1 part by weight of the raw materials are fully mixed to prepare the traditional Chinese medicine composition for treating beriberi.
In the case of the example 3, the following examples are given,
the traditional Chinese medicine composition for treating beriberi comprises main materials and auxiliary materials, wherein the main materials comprise the following components in formula: 50 parts of folium artemisiae argyi, 25 parts of ginger, 20 parts of pepper, 10 parts of dried orange peel and 15 parts of eucommia bark; the auxiliary material formula is as follows: 50 parts of alum and 30 parts of acetic acid.
The preparation method of the traditional Chinese medicine composition for treating beriberi comprises the following steps:
step one, preparing main materials
1) Taking 50 parts of folium artemisiae argyi, 25 parts of ginger, 20 parts of pepper, 10 parts of dried orange peel and 15 parts of eucommia ulmoides; respectively putting into a wall breaking machine for wall breaking and crushing, controlling the rotating speed at 28000 r/min, and then putting into a stirrer together for fully stirring to obtain a mixture;
2) adding the mixture into purified water 2 times the weight of the mixture, and fully soaking for 48 hours at the temperature of 20-25 ℃ to prepare a mixture soaking solution;
3) putting the mixture soak solution into a distillation pot, and then heating and distilling the mixture soak solution at the temperature of 100-110 ℃ to prepare a main material solution;
step two, preparing auxiliary materials
1) Taking 50 parts by weight of alum and 30 parts by weight of acetic acid; adding the mixture into a stirring kettle, and stirring to obtain a stirring solution;
2) adding the stirred solution into a distillation pot, and then heating and distilling, wherein the temperature is controlled to be between 100 and 110 ℃ to prepare an auxiliary material liquid;
step three, mixing the main feed liquid and the auxiliary material liquid according to the ratio of 1: 1 part by weight of the raw materials are fully mixed to prepare the traditional Chinese medicine composition for treating beriberi.
In the case of the example 4, the following examples are given,
the traditional Chinese medicine composition for treating beriberi comprises main materials and auxiliary materials, wherein the main materials comprise the following components in formula: 70 parts of folium artemisiae argyi, 40 parts of ginger, 35 parts of pepper, 35 parts of dried orange peel and 35 parts of eucommia bark; the auxiliary material formula is as follows: 80 parts of alum and 60 parts of acetic acid.
The preparation method of the traditional Chinese medicine composition for treating beriberi comprises the following steps:
step one, preparing main materials
1) Taking 70 parts of folium artemisiae argyi, 40 parts of ginger, 35 parts of pepper, 35 parts of dried orange peel and 35 parts of eucommia ulmoides; respectively putting into a wall breaking machine for wall breaking and crushing, controlling the rotating speed at 28000 r/min, and then putting into a stirrer together for fully stirring to obtain a mixture;
2) adding the mixture into purified water 2 times the weight of the mixture, and fully soaking for 48 hours at the temperature of 20-25 ℃ to prepare a mixture soaking solution;
3) putting the mixture soak solution into a distillation pot, and then heating and distilling the mixture soak solution at the temperature of 100-110 ℃ to prepare a main material solution;
step two, preparing auxiliary materials
1) Taking 80 parts by weight of alum and 60 parts by weight of acetic acid; adding the mixture into a stirring kettle, and stirring to obtain a stirring solution;
2) adding the stirred solution into a distillation pot, and then heating and distilling, wherein the temperature is controlled to be between 100 and 110 ℃ to prepare an auxiliary material liquid;
step three, mixing the main feed liquid and the auxiliary material liquid according to the ratio of 1: 1 part by weight of the raw materials are fully mixed to prepare the traditional Chinese medicine composition for treating beriberi.
Clinical cases:
case selection: 10 cases of beriberi and 30 erosive beriberi outpatients are randomly selected, wherein 25 men and 15 women are aged 16-47 years, the disease course is 1 year and the disease course is as long as 21 years.
Exclusion criteria: those known to be allergic to the relevant components of the test drug; patients with severe immunologic hypofunction or need long-term administration of corticosteroids and immunosuppressants; patients with serious impairment of heart, liver and kidney functions; those suffering from neuropsychiatric or severe circulatory and endocrine disorders; applying antifungal medicine to foot within 1 week; pregnant and lactating women; those who have a recent history of alcohol abuse or drug abuse; the patients who have participated in other beriberi treatment drug testers within 3 months.
Diagnostic criteria: small blisters appear on the toes and edges of the metatarsals, when the blisters are broken, the moist overflows, the smell is fishy, the subjective itching is difficult to endure, and when the rotten skin is soaked between the wiped and wiped toes repeatedly, a bright red rotten face appears after the skin is removed, and part of the toes are dry and itchy.
The test method comprises the following steps: the patient continuously sprays the traditional Chinese medicine composition for treating dermatophytosis on the affected part of the foot.
The curative effect standard is as follows: healing, eliminating erosion or herpes and dry fissure, no foot odor, no itching, no recurrence in summer; effectively, erosion, herpes, chapping and pruritus are obviously reduced; and (3) relapse: the cure is ineffective and the relapse occurs.
And (3) test results: 40 patients, 30 cases of patients are cured, including 23 erosive beriberi patients, 9 cases of effective patients and 1 case of relapse, the cure rate is 75%, and the total effective rate is 97.5%. The traditional Chinese medicine composition for treating beriberi has a good curative effect on erosive beriberi patients, and the cure rate reaches 76.7%.
Finally, the above embodiments are only for illustrating the technical solutions of the present invention and not for limiting, although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions may be made to the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention, and all of them should be covered in the claims of the present invention.
Claims (5)
1. The traditional Chinese medicine composition for treating beriberi comprises main materials and auxiliary materials, and is characterized in that the main materials comprise the following components in formula: 50-70 parts of folium artemisiae argyi, 25-40 parts of ginger, 20-35 parts of pepper, 10-35 parts of dried orange peel and 15-35 parts of eucommia bark; the auxiliary material formula is as follows: 50-80 parts of alum and 30-60 parts of acetic acid.
2. The traditional Chinese medicine composition for treating beriberi as claimed in claim 1, wherein the traditional Chinese medicine composition for treating beriberi comprises main materials and auxiliary materials, and the formula of the main materials is as follows: 60 parts of folium artemisiae argyi, 30 parts of ginger, 30 parts of pepper, 25 parts of dried orange peel and 25 parts of eucommia bark; the auxiliary material formula is as follows: 60 parts of alum and 40 parts of acetic acid.
3. The traditional Chinese medicine composition for treating beriberi as claimed in claim 1, wherein the traditional Chinese medicine composition for treating beriberi comprises main materials and auxiliary materials, and the formula of the main materials is as follows: 50 parts of folium artemisiae argyi, 25 parts of ginger, 20 parts of pepper, 10 parts of dried orange peel and 15 parts of eucommia bark; the auxiliary material formula is as follows: 50 parts of alum and 30 parts of acetic acid.
4. The traditional Chinese medicine composition for treating beriberi as claimed in claim 1, wherein the traditional Chinese medicine composition for treating beriberi comprises main materials and auxiliary materials, and the formula of the main materials is as follows: 70 parts of folium artemisiae argyi, 40 parts of ginger, 35 parts of pepper, 35 parts of dried orange peel and 35 parts of eucommia bark; the auxiliary material formula is as follows: 80 parts of alum and 60 parts of acetic acid.
5. A method for preparing the traditional Chinese medicine composition for treating dermatophytosis according to claim 1, which comprises the following steps:
step one, preparing the main material,
1) taking 50-70 parts of folium artemisiae argyi, 25-40 parts of ginger, 20-35 parts of pepper, 10-35 parts of dried orange peel and 15-35 parts of eucommia ulmoides; respectively putting into a wall breaking machine for wall breaking and crushing, controlling the rotating speed at 28000 r/min, and then putting into a stirrer together for fully stirring to obtain a mixture;
2) adding the mixture into purified water 2 times the weight of the mixture, and fully soaking for 24-48 hours at the temperature of 20-25 ℃ to obtain a mixture soaking solution;
3) putting the mixture soak solution into a distillation pot, and then heating and distilling the mixture soak solution at the temperature of 100-110 ℃ to prepare a main material solution;
step two, preparing auxiliary materials,
1) taking 50-80 parts by weight of alum and 30-60 parts by weight of acetic acid; adding the mixture into a stirring kettle, and stirring to obtain a stirring solution;
2) adding the stirred solution into a distillation pot, and then heating and distilling, wherein the temperature is controlled to be between 100 and 110 ℃ to prepare an auxiliary material liquid;
step three, mixing the main feed liquid and the auxiliary material liquid according to the ratio of 1: 1 part by weight of the raw materials are fully mixed to prepare the traditional Chinese medicine composition for treating beriberi.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN85104517A (en) * | 1985-05-21 | 1987-01-28 | 朝阳制药厂 | A kind of manufacture method for the treatment of foot, tinea manuum liquid medicine |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN85104517A (en) * | 1985-05-21 | 1987-01-28 | 朝阳制药厂 | A kind of manufacture method for the treatment of foot, tinea manuum liquid medicine |
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